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Aliases for ANAPC13 Gene

Aliases for ANAPC13 Gene

  • Anaphase Promoting Complex Subunit 13 2 3
  • APC13 3 4 6
  • Cyclosome Subunit 13 3 4
  • SWM1 3 6
  • Anaphase-Promoting Complex Subunit 13 3

External Ids for ANAPC13 Gene

Summaries for ANAPC13 Gene

Entrez Gene Summary for ANAPC13 Gene

  • This gene encodes a component of the anaphase promoting complex, a large ubiquitin-protein ligase that controls cell cycle progression by regulating the degradation of cell cycle regulators such as B-type cyclins. The encoded protein is evolutionarily conserved and is required for the integrity and ubiquitin ligase activity of the anaphase promoting complex. Pseudogenes and splice variants have been found for this gene; however, the biological validity of some of the splice variants has not been determined. [provided by RefSeq, Nov 2008]

GeneCards Summary for ANAPC13 Gene

ANAPC13 (Anaphase Promoting Complex Subunit 13) is a Protein Coding gene. Among its related pathways are Class I MHC mediated antigen processing and presentation and Oocyte meiosis.

UniProtKB/Swiss-Prot for ANAPC13 Gene

  • Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of Lys-11-linked polyubiquitin chains and, to a lower extent, the formation of Lys-48- and Lys-63-linked polyubiquitin chains.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ANAPC13 Gene

Genomics for ANAPC13 Gene

Genomic Location for ANAPC13 Gene

Start:
134,477,704 bp from pter
End:
134,486,716 bp from pter
Size:
9,013 bases
Orientation:
Minus strand

Genomic View for ANAPC13 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ANAPC13 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ANAPC13 Gene

Regulatory Elements for ANAPC13 Gene

Proteins for ANAPC13 Gene

  • Protein details for ANAPC13 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BS18-APC13_HUMAN
    Recommended name:
    Anaphase-promoting complex subunit 13
    Protein Accession:
    Q9BS18
    Secondary Accessions:
    • Q9Y3V0

    Protein attributes for ANAPC13 Gene

    Size:
    74 amino acids
    Molecular mass:
    8521 Da
    Quaternary structure:
    • The mammalian APC/C is composed of 14 distinct subunits that assemble into a complex of at least 19 chains with a combined molecular mass of around 1.2 MDa.
    SequenceCaution:
    • Sequence=CAB43251.1; Type=Erroneous translation; Note=Wrong choice of frame.; Evidence={ECO:0000305};

neXtProt entry for ANAPC13 Gene

Proteomics data for ANAPC13 Gene at MOPED

Post-translational modifications for ANAPC13 Gene

No Post-translational modifications

Other Protein References for ANAPC13 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for ANAPC13 Gene

Domains for ANAPC13 Gene

Gene Families for ANAPC13 Gene

HGNC:
  • ANAPC :Anaphase promoting complex subunits

Protein Domains for ANAPC13 Gene

InterPro:
ProtoNet:

UniProtKB/Swiss-Prot:

APC13_HUMAN
Family:
  • Belongs to the APC13 family.:
    • Q9BS18
genes like me logo Genes that share domains with ANAPC13: view

Function for ANAPC13 Gene

Molecular function for ANAPC13 Gene

UniProtKB/Swiss-Prot Function: Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of Lys-11-linked polyubiquitin chains and, to a lower extent, the formation of Lys-48- and Lys-63-linked polyubiquitin chains.

miRNA for ANAPC13 Gene

miRTarBase miRNAs that target ANAPC13

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for ANAPC13 Gene

Localization for ANAPC13 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ANAPC13 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ANAPC13 Gene COMPARTMENTS Subcellular localization image for ANAPC13 gene
Compartment Confidence
nucleus 5
extracellular 2
cytosol 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for ANAPC13 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005680 anaphase-promoting complex IDA 16364912
genes like me logo Genes that share ontologies with ANAPC13: view

Pathways for ANAPC13 Gene

genes like me logo Genes that share pathways with ANAPC13: view

UniProtKB/Swiss-Prot Q9BS18-APC13_HUMAN

  • Pathway: Protein modification; protein ubiquitination

Gene Ontology (GO) - Biological Process for ANAPC13 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007067 mitotic nuclear division IEA --
GO:0051301 cell division IEA --
GO:0070979 protein K11-linked ubiquitination IDA 18485873
genes like me logo Genes that share ontologies with ANAPC13: view

Transcripts for ANAPC13 Gene

Unigene Clusters for ANAPC13 Gene

Anaphase promoting complex subunit 13:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ANAPC13 Gene

ExUns: 1 ^ 2a · 2b · 2c · 2d ^ 3 ^ 4a · 4b · 4c ^ 5a · 5b · 5c · 5d · 5e
SP1: - - - - - - -
SP2: - - - -
SP3: - - -
SP4: - -
SP5: - -
SP6: -

Relevant External Links for ANAPC13 Gene

GeneLoc Exon Structure for
ANAPC13
ECgene alternative splicing isoforms for
ANAPC13

Expression for ANAPC13 Gene

mRNA expression in normal human tissues for ANAPC13 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for ANAPC13 Gene

SOURCE GeneReport for Unigene cluster for ANAPC13 Gene Hs.106909

genes like me logo Genes that share expressions with ANAPC13: view

Orthologs for ANAPC13 Gene

This gene was present in the common ancestor of animals.

Orthologs for ANAPC13 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ANAPC13 36
  • 100 (n)
  • 100 (a)
ANAPC13 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ANAPC13 36
  • 92.79 (n)
  • 100 (a)
ANAPC13 37
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ANAPC13 36
  • 94.59 (n)
  • 100 (a)
ANAPC13 37
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Anapc13 36
  • 86.94 (n)
  • 95.95 (a)
Anapc13 16
Anapc13 37
  • 96 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ANAPC13 37
  • 97 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Anapc13 36
  • 86.04 (n)
  • 95.95 (a)
chicken
(Gallus gallus)
Aves ANAPC13 36
  • 78.83 (n)
  • 97.3 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia anapc13.1 36
  • 74.77 (n)
  • 87.84 (a)
Str.10321 36
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.1080 36
zebrafish
(Danio rerio)
Actinopterygii anapc13 36
  • 72.52 (n)
  • 82.43 (a)
anapc13 37
  • 82 (a)
OneToOne
Dr.14480 36
fruit fly
(Drosophila melanogaster)
Insecta CG33981 37
  • 40 (a)
OneToOne
Species with no ortholog for ANAPC13:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ANAPC13 Gene

ENSEMBL:
Gene Tree for ANAPC13 (if available)
TreeFam:
Gene Tree for ANAPC13 (if available)

Paralogs for ANAPC13 Gene

Pseudogenes.org Pseudogenes for ANAPC13 Gene

genes like me logo Genes that share paralogs with ANAPC13: view

No data available for Paralogs for ANAPC13 Gene

Variants for ANAPC13 Gene

Sequence variations from dbSNP and Humsavar for ANAPC13 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type MAF
rs881205 -- 134,481,759(-) gtagG(G/T)CTTCA intron-variant
rs1814336 -- 134,481,981(-) CATAG(C/G)TTAGT intron-variant
rs1814337 -- 134,481,840(-) AGGGA(A/G)GTGCT intron-variant
rs1863913 -- 134,481,363(-) ATGGT(A/G)AGTCA intron-variant
rs2370577 -- 134,481,917(-) ATTTA(C/T)TGAAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ANAPC13 Gene

Variant ID Type Subtype PubMed ID
nsv877510 CNV Gain 21882294
dgv5259n71 CNV Loss 21882294
nsv829730 CNV Loss 17160897
esv33705 CNV Loss 17666407

Relevant External Links for ANAPC13 Gene

HapMap Linkage Disequilibrium report
ANAPC13

Disorders for ANAPC13 Gene

Relevant External Links for ANAPC13

Genetic Association Database (GAD)
ANAPC13
Human Genome Epidemiology (HuGE) Navigator
ANAPC13
genes like me logo Genes that share disorders with ANAPC13: view

No data available for UniProtKB/Swiss-Prot for ANAPC13 Gene

Publications for ANAPC13 Gene

  1. Swm1/Apc13 is an evolutionarily conserved subunit of the anaphase- promoting complex stabilizing the association of Cdc16 and Cdc27. (PMID: 15060174) Schwickart M. … Zachariae W. (Mol. Cell. Biol. 2004) 2 3 4
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  3. Localization of the coactivator Cdh1 and the cullin subunit Apc2 in a cryo-electron microscopy model of vertebrate APC/C. (PMID: 16364912) Dube P. … Stark H. (Mol. Cell 2005) 3 4
  4. Genome-wide association analysis identifies 20 loci that influence adult height. (PMID: 18391952) Weedon M.N. … Frayling T.M. (Nat. Genet. 2008) 3 49
  5. Mechanism of ubiquitin-chain formation by the human anaphase- promoting complex. (PMID: 18485873) Jin L. … Rape M. (Cell 2008) 3 4

Products for ANAPC13 Gene

Sources for ANAPC13 Gene

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