Aliases for ANAPC13 Gene
Aliases for ANAPC13 Gene
External Ids for ANAPC13 Gene
- HGNC: 24540
- Entrez Gene: 25847
- Ensembl: ENSG00000129055
- OMIM: 614484
- UniProtKB: Q9BS18
Previous GeneCards Identifiers for ANAPC13 Gene
- GC03M135518
- GC03M135679
- GC03M134196
- GC03M131574
Summaries for ANAPC13 Gene
-
This gene encodes a component of the anaphase promoting complex, a large ubiquitin-protein ligase that controls cell cycle progression by regulating the degradation of cell cycle regulators such as B-type cyclins. The encoded protein is evolutionarily conserved and is required for the integrity and ubiquitin ligase activity of the anaphase promoting complex. Pseudogenes and splice variants have been found for this gene; however, the biological validity of some of the splice variants has not been determined. [provided by RefSeq, Nov 2008]
GeneCards Summary for ANAPC13 Gene
ANAPC13 (Anaphase Promoting Complex Subunit 13) is a Protein Coding gene. Among its related pathways are G-protein signaling G-Protein alpha-i signaling cascades and Innate Immune System.
UniProtKB/Swiss-Prot for ANAPC13 Gene
-
Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of Lys-11-linked polyubiquitin chains and, to a lower extent, the formation of Lys-48- and Lys-63-linked polyubiquitin chains.
No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ANAPC13 Gene
Genomics for ANAPC13 Gene
Regulatory Elements for ANAPC13 Gene
| GeneHancer Identifier | Enhancer Score | Enhancer Sources | Gene-Enhancer Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites within enhancer | Gene Targets for Enhancer |
|---|---|---|---|---|---|---|---|---|
| GH03G134482 | 1.7 | FANTOM5 ENCODE dbSUPER | 74.4 | +1.5 | 1483 | 6.0 | HDGF HNRNPUL1 PKNOX1 FOXA2 MLX ARNT CREB3L1 ARID4B SIN3A DMAP1 | ANAPC13 CEP63 MIR4788 |
| GH03G134460 | 1.6 | FANTOM5 Ensembl ENCODE dbSUPER | 68.7 | +23.2 | 23190 | 6.8 | TEAD4 MAX SIN3A RBBP5 BMI1 ZNF316 POLR2A FOS MAFK NFE2L2 | ANAPC13 AMOTL2 CEP63 MIR4788 |
| GH03G134471 | 1.2 | Ensembl ENCODE dbSUPER | 67.1 | +13.8 | 13776 | 3.4 | CTCF TEAD4 MAX SIN3A RAD21 RFX5 TEAD3 GATA3 ZNF143 SMC3 | ANAPC13 RYK CEP63 MIR4788 |
| GH03G134496 | 1.2 | ENCODE dbSUPER | 65.1 | -9.9 | -9863 | 0.8 | PKNOX1 ATF1 ARNT TCF12 ZNF766 ELK1 GATA2 CAVIN1 JUNB ZNF592 | ANAPC13 SLCO2A1 LOC100421154 |
| GH03G134476 | 0.9 | ENCODE dbSUPER | 73 | +9.2 | 9190 | 2.9 | CTCF ZNF654 TRIM22 RAD21 FOSL1 ZNF579 JUND GATA3 GATA2 ATF3 | ANAPC13 CEP63 MIR4788 |
- Transcription factor binding sites by QIAGEN in the ANAPC13 gene promoter:
Regulatory Element Products
Genomic Location for ANAPC13 Gene
- Chromosome:
- 3
- Start:
- 134,477,704 bp from pter
- End:
- 134,486,716 bp from pter
- Size:
- 9,013 bases
- Orientation:
- Minus strand
Genomic View for ANAPC13 Gene
- Cytogenetic band:
-
- 3q22.2 by Ensembl
- 3q22.2 by Entrez Gene
- 3q22.2 by HGNC
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for ANAPC13 Gene
Proteins for ANAPC13 Gene
-
Protein details for ANAPC13 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q9BS18-APC13_HUMAN
- Recommended name:
- Anaphase-promoting complex subunit 13
- Protein Accession:
- Q9BS18
- Q9Y3V0
Protein attributes for ANAPC13 Gene
- Size:
- 74 amino acids
- Molecular mass:
- 8521 Da
- Quaternary structure:
-
- The mammalian APC/C is composed of 14 distinct subunits that assemble into a complex of at least 19 chains with a combined molecular mass of around 1.2 MDa.
- SequenceCaution:
-
- Sequence=CAB43251.1; Type=Erroneous translation; Note=Wrong choice of frame.; Evidence={ECO:0000305};
Protein Expression for ANAPC13 Gene
Post-translational modifications for ANAPC13 Gene
Other Protein References for ANAPC13 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- Novus Biologicals Antibodies for ANAPC13
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- antibodies-online Antibodies for ANAPC13: See all 16
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-
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Protein Products
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Assay Products
- antibodies-online Kits for ANAPC13: See all 8
No data available for DME Specific Peptides for ANAPC13 Gene
Domains & Families for ANAPC13 Gene
Gene Families for ANAPC13 Gene
Suggested Antigen Peptide Sequences for ANAPC13 Gene
Graphical View of Domain Structure for InterPro Entry
Q9BS18- Family:
-
- Belongs to the APC13 family.
Function for ANAPC13 Gene
Molecular function for ANAPC13 Gene
- UniProtKB/Swiss-Prot Function:
- Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of Lys-11-linked polyubiquitin chains and, to a lower extent, the formation of Lys-48- and Lys-63-linked polyubiquitin chains.
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005515 | protein binding | IPI | 20360068 |
Phenotypes for ANAPC13 Gene
- MGI mutant phenotypes for ANAPC13:
- inferred from 1 alleles
- GenomeRNAi human phenotypes for ANAPC13:
Animal Models for ANAPC13 Gene
- MGI Knock Outs for ANAPC13:
-
- Anapc13 tm2b(EUCOMM)Wtsi
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
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-
-
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-
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CRISPR Products
-
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-
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miRNA for ANAPC13 Gene
- miRTarBase miRNAs that target ANAPC13
-
- hsa-mir-26b-5p (MIRT029001)
- hsa-mir-16-5p (MIRT031495)
- hsa-mir-324-5p (MIRT043053)
- hsa-mir-3180-5p (MIRT543401)
- hsa-mir-6720-5p (MIRT543402)
- hsa-mir-6512-3p (MIRT543403)
- hsa-mir-338-3p (MIRT543404)
- hsa-mir-6838-5p (MIRT543405)
- hsa-mir-4530 (MIRT543406)
- hsa-mir-497-5p (MIRT543407)
- hsa-mir-424-5p (MIRT543408)
- hsa-mir-195-5p (MIRT543409)
- hsa-mir-15b-5p (MIRT543410)
- hsa-mir-15a-5p (MIRT543411)
- hsa-mir-4773 (MIRT543412)
- hsa-mir-6891-5p (MIRT543413)
- hsa-mir-3173-3p (MIRT543414)
- hsa-mir-4428 (MIRT543415)
miRNA Products
- Search ViGene Biosciences for ANAPC13
Inhibitory RNA Products
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-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Cell Line Products
-
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Flow Cytometry Products
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ANAPC13 Gene
Localization for ANAPC13 Gene
Subcellular locations from UniProtKB/Swiss-Prot for ANAPC13 Gene
- Nucleus.
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005634 | nucleus | IEA | -- |
| GO:0005680 | anaphase-promoting complex | IDA | 16364912 |
Pathways & Interactions for ANAPC13 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Class I MHC mediated antigen processing and presentation | ||
| 2 | Oocyte meiosis |
.41
|
|
| 3 | Cell cycle Role of SCF complex in cell cycle regulation | ||
| 4 | Cell cycle |
.58
|
|
| 5 | Ubiquitin mediated proteolysis | ||
Pathways by source for ANAPC13 Gene
1 Sino Biological pathway for ANAPC13 Gene
4 Reactome pathways for ANAPC13 Gene
4 KEGG pathways for ANAPC13 Gene
7 GeneGo (Thomson Reuters) pathways for ANAPC13 Gene
UniProtKB/Swiss-Prot Q9BS18-APC13_HUMAN
- Pathway: Protein modification; protein ubiquitination.
Interacting Proteins for ANAPC13 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0007049 | cell cycle | IEA | -- |
| GO:0007067 | mitotic nuclear division | IEA | -- |
| GO:0016567 | protein ubiquitination | IEA | -- |
| GO:0051301 | cell division | IEA | -- |
| GO:0070979 | protein K11-linked ubiquitination | IDA | 18485873 |
No data available for SIGNOR curated interactions for ANAPC13 Gene
Drugs & Compounds for ANAPC13 Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| TAME | Pharma | 0 |
(1) ApexBio Compounds for ANAPC13 Gene
| Compound | Action | Cas Number |
|---|---|---|
| TAME | 901-47-3 |
Drug Products
- ApexBio compounds for ANAPC13
Transcripts for ANAPC13 Gene
mRNA/cDNA for ANAPC13 Gene
- (3) REFSEQ mRNAs :
- (7) Additional mRNA sequences :
- (494) Selected AceView cDNA sequences:
- (6) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for ANAPC13 Gene
- Anaphase promoting complex subunit 13:
- Representative Sequences:
CRISPR Products
-
OriGene CRISPR knockouts for ANAPC13
-
Santa Cruz Biotechnology (SCBT) CRISPR for ANAPC13
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miRNA Products
- Search ViGene Biosciences for ANAPC13
Inhibitory RNA Products
- Origene shRNA, siRNA, and RNAi products in human, mouse, rat for ANAPC13
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-
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Clone Products
- Sino Biological Human cDNA Clone for ANAPC13
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- VectorBuilder custom plasmid, inducible vectors for ANAPC13
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for ANAPC13
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Flow Cytometry Products
| ExUns: | 1 | ^ | 2a | · | 2b | · | 2c | · | 2d | ^ | 3 | ^ | 4a | · | 4b | · | 4c | ^ | 5a | · | 5b | · | 5c | · | 5d | · | 5e |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | - | - | - | - | ||||||||||||||||||||
| SP2: | - | - | - | - | |||||||||||||||||||||||
| SP3: | - | - | - | ||||||||||||||||||||||||
| SP4: | - | - | |||||||||||||||||||||||||
| SP5: | - | - | |||||||||||||||||||||||||
| SP6: | - |
Expression for ANAPC13 Gene
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for ANAPC13 Gene
NURSA nuclear receptor signaling pathways regulating expression of ANAPC13 Gene:
ANAPC13SOURCE GeneReport for Unigene cluster for ANAPC13 Gene:
Hs.106909Evidence on tissue expression from TISSUES for ANAPC13 Gene
- Kidney(4.4)
- Nervous system(4.1)
Primer Products
-
OriGene qPCR primer pairs and template standards for ANAPC13
-
OriGene qPCR primer pairs for ANAPC13
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ANAPC13 Gene
Orthologs for ANAPC13 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | ANAPC13 34 35 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | ANAPC13 35 |
|
OneToOne | |
| dog (Canis familiaris) |
Mammalia | ANAPC13 34 35 |
|
||
| cow (Bos Taurus) |
Mammalia | ANAPC13 34 35 |
|
||
| mouse (Mus musculus) |
Mammalia | Anapc13 34 16 35 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Anapc13 34 |
|
||
| chicken (Gallus gallus) |
Aves | ANAPC13 34 |
|
||
| tropical clawed frog (Silurana tropicalis) |
Amphibia | anapc13.1 34 |
|
||
| Str.10321 34 |
|
||||
| zebrafish (Danio rerio) |
Actinopterygii | anapc13 34 35 |
|
||
| Dr.14480 34 |
|
||||
| rainbow trout (Oncorhynchus mykiss) |
Actinopterygii | Omy.1080 34 |
|
||
| fruit fly (Drosophila melanogaster) |
Insecta | CG33981 35 |
|
OneToOne |
- Species where no ortholog for ANAPC13 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- lizard (Anolis carolinensis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- platypus (Ornithorhynchus anatinus)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Paralogs for ANAPC13 Gene
Pseudogenes.org Pseudogenes for ANAPC13 Gene
No data available for Paralogs for ANAPC13 Gene
Variants for ANAPC13 Gene
| SNP ID | Clin | Chr 03 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs1000813621 | -- | 134,483,450(+) | CACCA(-/G)TGGTA | intron-variant | |
| rs1000849571 | -- | 134,478,736(+) | AGAAA(A/T)TCAGA | intron-variant | |
| rs1001369834 | -- | 134,485,301(+) | CCTGA(A/G)CAAAC | intron-variant, upstream-variant-2KB | |
| rs1002333677 | -- | 134,482,892(+) | CTGAA(A/C)CTCAC | reference, missense | |
| rs1002660373 | -- | 134,485,998(+) | CCCCC(C/T)CCCCT | upstream-variant-2KB, utr-variant-5-prime |
Relevant External Links for ANAPC13 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- ANAPC13
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ANAPC13 Gene
Disorders for ANAPC13 Gene
Relevant External Links for ANAPC13
No disorders were found for ANAPC13 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ANAPC13 Gene
Publications for ANAPC13 Gene
- Swm1/Apc13 is an evolutionarily conserved subunit of the anaphase- promoting complex stabilizing the association of Cdc16 and Cdc27. (PMID: 15060174) Schwickart M. … Zachariae W. (Mol. Cell. Biol. 2004) 2 3 4 64
- Molecular architecture and mechanism of the anaphase-promoting complex. (PMID: 25043029) Chang L. … Barford D. (Nature 2014) 3 4 64
- The role of height-associated loci identified in genome wide association studies in the determination of pediatric stature. (PMID: 20546612) Zhao J. … Grant S.F. (BMC Med. Genet. 2010) 3 46 64
- Association of linear growth impairment in pediatric Crohn's disease and a known height locus: a pilot study. (PMID: 20846217) Lee J.J. … Hirschhorn J. (Ann. Hum. Genet. 2010) 3 46 64
- Mechanism of ubiquitin-chain formation by the human anaphase- promoting complex. (PMID: 18485873) Jin L. … Rape M. (Cell 2008) 3 4 64
Products for ANAPC13 Gene
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- VectorBuilder custom plasmid, inducible vectors for ANAPC13
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for ANAPC13
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Sources for ANAPC13 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) RNAdb
- (29) ASD
- (30) ECgene
- (31) GeneAnnot
- (32) CGAP SAGE
- (33) SOURCE
- (34) HomoloGene
- (35) PanEnsembl
- (36) euGenes
- (37) SGD
- (38) FlyBase
- (39) WormBase
- (40) Pseudogene
- (41) DGV
- (42) dbSNP
- (43) GenAtlas
- (44) GeneTests
- (45) HGMD
- (46) GAD
- (47) LSDB
- (48) BGMUT
- (49) HuGE
- (50) eBioscience
- (51) Atlas
- (52) Cell Signaling Technology
- (53) GenBank
- (54) H-invDB
- (55) HORDE
- (56) HUGE
- (57) IMGT
- (58) Leiden
- (59) MILLIPORE
- (60) miRBase
- (61) DME
- (62) NCBI
- (63) OriGene
- (64) PubMed
- (65) R&D Systems
- (66) TGDB
- (67) Tocris
- (68) Abcam
- (69) Novus
- (70) ProSpec
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- (72) GenScript
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- (74) Cloud-Clone Corp.
- (75) Enzo Life Sciences
- (76) OCA
- (77) Proteopedia
- (78) MOPED
- (79) SPIRE
- (80) neXtProt
- (81) Reactome
- (82) GeneGo (Thomson Reuters)
- (83) fRNAdb
- (84) DISEASES
- (85) SIMAP
- (86) GenomeRNAi
- (87) LifeMap
- (88) miRTarBase
- (89) MalaCards
- (90) Invitrogen
- (91) BitterDB
- (92) Vector BioLabs
- (93) ESI-BIO
- (94) RefSeq
- (95) BioSystems
- (96) MaxQB
- (97) IUPHAR
- (98) BioGPS
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