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Aliases for ANAPC13 Gene

Aliases for ANAPC13 Gene

  • Anaphase Promoting Complex Subunit 13 2 3 5
  • Cyclosome Subunit 13 3 4
  • APC13 3 4
  • SWM1 3

External Ids for ANAPC13 Gene

Previous GeneCards Identifiers for ANAPC13 Gene

  • GC03M135518
  • GC03M135679
  • GC03M134196
  • GC03M131574

Summaries for ANAPC13 Gene

Entrez Gene Summary for ANAPC13 Gene

  • This gene encodes a component of the anaphase promoting complex, a large ubiquitin-protein ligase that controls cell cycle progression by regulating the degradation of cell cycle regulators such as B-type cyclins. The encoded protein is evolutionarily conserved and is required for the integrity and ubiquitin ligase activity of the anaphase promoting complex. Pseudogenes and splice variants have been found for this gene; however, the biological validity of some of the splice variants has not been determined. [provided by RefSeq, Nov 2008]

GeneCards Summary for ANAPC13 Gene

ANAPC13 (Anaphase Promoting Complex Subunit 13) is a Protein Coding gene. Among its related pathways are Antigen processing- Ubiquitination and Proteasome degradation and Cell cycle Role of SCF complex in cell cycle regulation.

UniProtKB/Swiss-Prot for ANAPC13 Gene

  • Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of Lys-11-linked polyubiquitin chains and, to a lower extent, the formation of Lys-48- and Lys-63-linked polyubiquitin chains.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ANAPC13 Gene

Genomics for ANAPC13 Gene

Regulatory Elements for ANAPC13 Gene

Enhancers for ANAPC13 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around ANAPC13 on UCSC Golden Path with GeneCards custom track

Promoters for ANAPC13 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around ANAPC13 on UCSC Golden Path with GeneCards custom track

Genomic Location for ANAPC13 Gene

Chromosome:
3
Start:
134,477,704 bp from pter
End:
134,486,716 bp from pter
Size:
9,013 bases
Orientation:
Minus strand

Genomic View for ANAPC13 Gene

Genes around ANAPC13 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ANAPC13 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ANAPC13 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ANAPC13 Gene

Proteins for ANAPC13 Gene

  • Protein details for ANAPC13 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BS18-APC13_HUMAN
    Recommended name:
    Anaphase-promoting complex subunit 13
    Protein Accession:
    Q9BS18
    Secondary Accessions:
    • Q9Y3V0

    Protein attributes for ANAPC13 Gene

    Size:
    74 amino acids
    Molecular mass:
    8521 Da
    Quaternary structure:
    • The mammalian APC/C is composed of 14 distinct subunits that assemble into a complex of at least 19 chains with a combined molecular mass of around 1.2 MDa.
    SequenceCaution:
    • Sequence=CAB43251.1; Type=Erroneous translation; Note=Wrong choice of frame.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for ANAPC13 Gene

neXtProt entry for ANAPC13 Gene

Proteomics data for ANAPC13 Gene at MOPED

Post-translational modifications for ANAPC13 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ANAPC13 Gene

Antibody Products

No data available for DME Specific Peptides for ANAPC13 Gene

Domains & Families for ANAPC13 Gene

Gene Families for ANAPC13 Gene

Protein Domains for ANAPC13 Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

Q9BS18

UniProtKB/Swiss-Prot:

APC13_HUMAN :
  • Belongs to the APC13 family.
Family:
  • Belongs to the APC13 family.
genes like me logo Genes that share domains with ANAPC13: view

Function for ANAPC13 Gene

Molecular function for ANAPC13 Gene

UniProtKB/Swiss-Prot Function:
Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of Lys-11-linked polyubiquitin chains and, to a lower extent, the formation of Lys-48- and Lys-63-linked polyubiquitin chains.

Phenotypes for ANAPC13 Gene

genes like me logo Genes that share phenotypes with ANAPC13: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ANAPC13 Gene

Localization for ANAPC13 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ANAPC13 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ANAPC13 Gene COMPARTMENTS Subcellular localization image for ANAPC13 gene
Compartment Confidence
nucleus 5
cytosol 2
extracellular 2
mitochondrion 2

No data available for Gene Ontology (GO) - Cellular Components for ANAPC13 Gene

Pathways & Interactions for ANAPC13 Gene

genes like me logo Genes that share pathways with ANAPC13: view

UniProtKB/Swiss-Prot Q9BS18-APC13_HUMAN

  • Pathway: Protein modification; protein ubiquitination.

Gene Ontology (GO) - Biological Process for ANAPC13 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0051301 cell division IEA --
genes like me logo Genes that share ontologies with ANAPC13: view

No data available for SIGNOR curated interactions for ANAPC13 Gene

Drugs & Compounds for ANAPC13 Gene

(1) Drugs for ANAPC13 Gene - From: ApexBio

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
TAME Pharma 0

(1) ApexBio Compounds for ANAPC13 Gene

Compound Action Cas Number
TAME 901-47-3
genes like me logo Genes that share compounds with ANAPC13: view

Transcripts for ANAPC13 Gene

Unigene Clusters for ANAPC13 Gene

Anaphase promoting complex subunit 13:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ANAPC13 Gene

ExUns: 1 ^ 2a · 2b · 2c · 2d ^ 3 ^ 4a · 4b · 4c ^ 5a · 5b · 5c · 5d · 5e
SP1: - - - - - - -
SP2: - - - -
SP3: - - -
SP4: - -
SP5: - -
SP6: -

Relevant External Links for ANAPC13 Gene

GeneLoc Exon Structure for
ANAPC13
ECgene alternative splicing isoforms for
ANAPC13

Expression for ANAPC13 Gene

mRNA expression in normal human tissues for ANAPC13 Gene

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for ANAPC13 Gene



SOURCE GeneReport for Unigene cluster for ANAPC13 Gene Hs.106909

genes like me logo Genes that share expression patterns with ANAPC13: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for ANAPC13 Gene

Orthologs for ANAPC13 Gene

This gene was present in the common ancestor of animals.

Orthologs for ANAPC13 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia ANAPC13 35
  • 92.79 (n)
  • 100 (a)
ANAPC13 36
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ANAPC13 35
  • 94.59 (n)
  • 100 (a)
ANAPC13 36
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Anapc13 35
  • 86.94 (n)
  • 95.95 (a)
Anapc13 16
Anapc13 36
  • 96 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia ANAPC13 35
  • 100 (n)
  • 100 (a)
ANAPC13 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Anapc13 35
  • 86.04 (n)
  • 95.95 (a)
oppossum
(Monodelphis domestica)
Mammalia ANAPC13 36
  • 97 (a)
OneToOne
chicken
(Gallus gallus)
Aves ANAPC13 35
  • 78.83 (n)
  • 97.3 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia anapc13.1 35
  • 74.77 (n)
  • 87.84 (a)
Str.10321 35
zebrafish
(Danio rerio)
Actinopterygii anapc13 35
  • 72.52 (n)
  • 82.43 (a)
Dr.14480 35
anapc13 36
  • 82 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.1080 35
fruit fly
(Drosophila melanogaster)
Insecta CG33981 36
  • 40 (a)
OneToOne
Species with no ortholog for ANAPC13:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ANAPC13 Gene

ENSEMBL:
Gene Tree for ANAPC13 (if available)
TreeFam:
Gene Tree for ANAPC13 (if available)

Paralogs for ANAPC13 Gene

Pseudogenes.org Pseudogenes for ANAPC13 Gene

genes like me logo Genes that share paralogs with ANAPC13: view

No data available for Paralogs for ANAPC13 Gene

Variants for ANAPC13 Gene

Sequence variations from dbSNP and Humsavar for ANAPC13 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs1863913 -- 134,481,363(-) ATGGT(A/G)AGTCA intron-variant
rs2370577 -- 134,481,917(-) ATTTA(C/T)TGAAT intron-variant
rs2370578 -- 134,480,770(-) cttgc(C/T)tgtgt intron-variant
rs881205 -- 134,481,759(-) gtagG(G/T)CTTCA intron-variant
rs4498009 -- 134,479,166(+) GCACT(C/G)TGTGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ANAPC13 Gene

Variant ID Type Subtype PubMed ID
nsv877510 CNV Gain 21882294
dgv5259n71 CNV Loss 21882294
nsv829730 CNV Loss 17160897
esv33705 CNV Loss 17666407

Variation tolerance for ANAPC13 Gene

Residual Variation Intolerance Score: 50.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.31; 6.96% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for ANAPC13 Gene

Disorders for ANAPC13 Gene

Relevant External Links for ANAPC13

Genetic Association Database (GAD)
ANAPC13
Human Genome Epidemiology (HuGE) Navigator
ANAPC13
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ANAPC13

No disorders were found for ANAPC13 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ANAPC13 Gene

Publications for ANAPC13 Gene

  1. Swm1/Apc13 is an evolutionarily conserved subunit of the anaphase- promoting complex stabilizing the association of Cdc16 and Cdc27. (PMID: 15060174) Schwickart M. … Zachariae W. (Mol. Cell. Biol. 2004) 2 3 4 67
  2. Structure of an APC3-APC16 complex: insights into assembly of the anaphase-promoting complex/cyclosome. (PMID: 25490258) Yamaguchi M. … Schulman B.A. (J. Mol. Biol. 2015) 3
  3. Atomic structure of the APC/C and its mechanism of protein ubiquitination. (PMID: 26083744) Chang L. … Barford D. (Nature 2015) 3
  4. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3
  5. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3

Products for ANAPC13 Gene

Sources for ANAPC13 Gene

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