Aliases for ANAPC11 Gene
External Ids for ANAPC11 Gene
Previous GeneCards Identifiers for ANAPC11 Gene
GeneCards Summary for ANAPC11 Gene
ANAPC11 (Anaphase Promoting Complex Subunit 11) is a Protein Coding gene. Among its related pathways are Immune System and Activation of cAMP-Dependent PKA. GO annotations related to this gene include ubiquitin-protein transferase activity and ubiquitin-ubiquitin ligase activity.
UniProtKB/Swiss-Prot for ANAPC11 Gene
Together with the cullin protein ANAPC2, constitutes the catalytic component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of Lys-11-linked polyubiquitin chains and, to a lower extent, the formation of Lys-48- and Lys-63-linked polyubiquitin chains. May recruit the E2 ubiquitin-conjugating enzymes to the complex.