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Aliases for ANAPC11 Gene

Aliases for ANAPC11 Gene

  • Anaphase Promoting Complex Subunit 11 2 3 5
  • Anaphase Promoting Complex Subunit 11 (Yeast APC11 Homolog) 2 3
  • Hepatocellular Carcinoma-Associated RING Finger Protein 3 4
  • Cyclosome Subunit 11 3 4
  • APC11 3 4
  • APC11 Anaphase Promoting Complex Subunit 11 Homolog 3
  • HSPC214 3
  • Apc11p 3

External Ids for ANAPC11 Gene

Previous GeneCards Identifiers for ANAPC11 Gene

  • GC17P079341
  • GC17P9I0152
  • GC17P080384
  • GC17P077442
  • GC17P079849
  • GC17P075220

Summaries for ANAPC11 Gene

GeneCards Summary for ANAPC11 Gene

ANAPC11 (Anaphase Promoting Complex Subunit 11) is a Protein Coding gene. Among its related pathways are Immune System and Cellular Senescence. GO annotations related to this gene include ubiquitin-protein transferase activity and ubiquitin-ubiquitin ligase activity.

UniProtKB/Swiss-Prot for ANAPC11 Gene

  • Together with the cullin protein ANAPC2, constitutes the catalytic component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of Lys-11-linked polyubiquitin chains and, to a lower extent, the formation of Lys-48- and Lys-63-linked polyubiquitin chains. May recruit the E2 ubiquitin-conjugating enzymes to the complex.

Gene Wiki entry for ANAPC11 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ANAPC11 Gene

Genomics for ANAPC11 Gene

Regulatory Elements for ANAPC11 Gene

Promoters for ANAPC11 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around ANAPC11 on UCSC Golden Path with GeneCards custom track

Transcription factor binding sites by QIAGEN in the ANAPC11 gene promoter:

Genomic Location for ANAPC11 Gene

Chromosome:
17
Start:
81,890,790 bp from pter
End:
81,900,991 bp from pter
Size:
10,202 bases
Orientation:
Plus strand

Genomic View for ANAPC11 Gene

Genes around ANAPC11 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ANAPC11 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ANAPC11 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ANAPC11 Gene

Proteins for ANAPC11 Gene

  • Protein details for ANAPC11 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NYG5-APC11_HUMAN
    Recommended name:
    Anaphase-promoting complex subunit 11
    Protein Accession:
    Q9NYG5
    Secondary Accessions:
    • A8MTT2
    • B7ZW64
    • Q502X9
    • Q9BW64
    • Q9P0R2

    Protein attributes for ANAPC11 Gene

    Size:
    84 amino acids
    Molecular mass:
    9841 Da
    Quaternary structure:
    • The mammalian APC/C is composed of 14 distinct subunits that assemble into a complex of at least 19 chains with a combined molecular mass of around 1.2 MDa. Interacts with the cullin domain of ANAPC2. Interacts with UBE2D2.
    SequenceCaution:
    • Sequence=AAF36134.1; Type=Frameshift; Positions=67; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for ANAPC11 Gene

    Alternative splice isoforms for ANAPC11 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ANAPC11 Gene

Proteomics data for ANAPC11 Gene at MOPED

Post-translational modifications for ANAPC11 Gene

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for ANAPC11 (APC11)

No data available for DME Specific Peptides for ANAPC11 Gene

Domains & Families for ANAPC11 Gene

Gene Families for ANAPC11 Gene

Protein Domains for ANAPC11 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for ANAPC11 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9NYG5

UniProtKB/Swiss-Prot:

APC11_HUMAN :
  • The RING-type zinc finger domain coordinates an additional third zinc ion.
  • Belongs to the RING-box family.
  • Contains 1 RING-type zinc finger.
Domain:
  • The RING-type zinc finger domain coordinates an additional third zinc ion.
Family:
  • Belongs to the RING-box family.
Similarity:
  • Contains 1 RING-type zinc finger.
genes like me logo Genes that share domains with ANAPC11: view

Function for ANAPC11 Gene

Molecular function for ANAPC11 Gene

UniProtKB/Swiss-Prot Function:
Together with the cullin protein ANAPC2, constitutes the catalytic component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of Lys-11-linked polyubiquitin chains and, to a lower extent, the formation of Lys-48- and Lys-63-linked polyubiquitin chains. May recruit the E2 ubiquitin-conjugating enzymes to the complex.

Gene Ontology (GO) - Molecular Function for ANAPC11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004842 contributes_to ubiquitin-protein transferase activity IEA,IDA 11739784
GO:0005515 protein binding IEA --
genes like me logo Genes that share ontologies with ANAPC11: view
genes like me logo Genes that share phenotypes with ANAPC11: view

Animal Model Products

CRISPR Products

miRNA for ANAPC11 Gene

miRTarBase miRNAs that target ANAPC11

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ANAPC11 Gene

Localization for ANAPC11 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ANAPC11 Gene

Cytoplasm. Nucleus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ANAPC11 Gene COMPARTMENTS Subcellular localization image for ANAPC11 gene
Compartment Confidence
cytosol 5
nucleus 5
extracellular 3

No data available for Gene Ontology (GO) - Cellular Components for ANAPC11 Gene

Pathways & Interactions for ANAPC11 Gene

SuperPathways for ANAPC11 Gene

Superpath Contained pathways
1 CDK-mediated phosphorylation and removal of Cdc6
2 APC-Cdc20 mediated degradation of Nek2A
3 Cellular Senescence
4 Cell Cycle, Mitotic
.61
5 Mitotic Metaphase and Anaphase
genes like me logo Genes that share pathways with ANAPC11: view

UniProtKB/Swiss-Prot Q9NYG5-APC11_HUMAN

  • Pathway: Protein modification; protein ubiquitination.

Gene Ontology (GO) - Biological Process for ANAPC11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007067 mitotic nuclear division TAS 11739784
GO:0016567 protein ubiquitination IEA,IDA 11739784
GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process TAS --
GO:0045842 positive regulation of mitotic metaphase/anaphase transition IBA --
GO:0051301 cell division IEA --
genes like me logo Genes that share ontologies with ANAPC11: view

No data available for SIGNOR curated interactions for ANAPC11 Gene

Drugs & Compounds for ANAPC11 Gene

(1) Drugs for ANAPC11 Gene - From: ApexBio

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
TAME Pharma 0
genes like me logo Genes that share compounds with ANAPC11: view

Transcripts for ANAPC11 Gene

Unigene Clusters for ANAPC11 Gene

Anaphase promoting complex subunit 11:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ANAPC11 Gene

ExUns: 1 ^ 2a · 2b · 2c · 2d · 2e · 2f ^ 3a · 3b · 3c ^ 4 ^ 5 ^ 6a · 6b · 6c · 6d ^ 7 ^ 8a · 8b · 8c · 8d · 8e · 8f
SP1: - - - - - - - -
SP2: - - - - - - - - -
SP3: - - - - - - - - - - - - - -
SP4: - - - - - - - - -
SP5: - - - - - - - - - -
SP6: - - - - - - - -
SP7: - - - - - - - -
SP8: - - - - -
SP9: - - - -
SP10: - - - - - - - - - - -
SP11: - - - - - -
SP12: - - - - - - - - - -
SP13: - - - - - - - - -
SP14: - - - - -
SP15: - - - - - - - - -
SP16: - - - - - -
SP17: - - -

Relevant External Links for ANAPC11 Gene

GeneLoc Exon Structure for
ANAPC11
ECgene alternative splicing isoforms for
ANAPC11

Expression for ANAPC11 Gene

mRNA expression in normal human tissues for ANAPC11 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for ANAPC11 Gene

This gene is overexpressed in Bone (56.3) and Lung (12.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ANAPC11 Gene



SOURCE GeneReport for Unigene cluster for ANAPC11 Gene Hs.534456

mRNA Expression by UniProt/SwissProt for ANAPC11 Gene

Q9NYG5-APC11_HUMAN
Tissue specificity: Expressed at high levels in skeletal muscle and heart; in moderate levels in brain, kidney, and liver; and at low levels in colon, thymus, spleen, small intestine, placenta, lung and peripheral blood leukocyte.
genes like me logo Genes that share expression patterns with ANAPC11: view

Protein tissue co-expression partners for ANAPC11 Gene

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for ANAPC11 Gene

Orthologs for ANAPC11 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for ANAPC11 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia ANAPC11 35
  • 92.86 (n)
  • 97.62 (a)
ANAPC11 36
  • 50 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ANAPC11 35
  • 93.25 (n)
  • 98.81 (a)
ANAPC11 36
  • 51 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Anapc11 35
  • 89.29 (n)
  • 98.81 (a)
Anapc11 16
Anapc11 36
  • 51 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia ANAPC11 35
  • 99.21 (n)
  • 100 (a)
ANAPC11 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Anapc11 35
  • 89.29 (n)
  • 98.81 (a)
platypus
(Ornithorhynchus anatinus)
Mammalia ANAPC11 36
  • 42 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia anapc11 35
  • 82.14 (n)
  • 88.1 (a)
zebrafish
(Danio rerio)
Actinopterygii anapc11 35
  • 79.37 (n)
  • 91.67 (a)
anapc11 36
  • 44 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta lmg 37
  • 73 (a)
lmgA 35
  • 74.7 (n)
  • 72.29 (a)
lmg 36
  • 41 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP008196 35
  • 72.69 (n)
  • 71.08 (a)
worm
(Caenorhabditis elegans)
Secernentea apc-11 36
  • 16 (a)
OneToOne
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AER016C 35
  • 59.92 (n)
  • 50 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes APC11 35
  • 54.76 (n)
  • 53.57 (a)
APC11 36
  • 19 (a)
OneToOne
APC11 38
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0E17711g 35
  • 49.21 (n)
  • 46.03 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons APC11 35
  • 61.79 (n)
  • 68.29 (a)
rice
(Oryza sativa)
Liliopsida Os07g0411101 35
  • 69.88 (n)
  • 69.88 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU11300 35
  • 64.91 (n)
  • 61.4 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes apc11 35
  • 54.58 (n)
  • 53.75 (a)
Species with no ortholog for ANAPC11:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ANAPC11 Gene

ENSEMBL:
Gene Tree for ANAPC11 (if available)
TreeFam:
Gene Tree for ANAPC11 (if available)

Paralogs for ANAPC11 Gene

(12) SIMAP similar genes for ANAPC11 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with ANAPC11: view

No data available for Paralogs for ANAPC11 Gene

Variants for ANAPC11 Gene

Sequence variations from dbSNP and Humsavar for ANAPC11 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs11431521 -- 81,897,006(+) TATTT(-/A)TTTAT intron-variant
rs11550400 -- 81,900,024(+) AGCAG(C/T)ACTGC reference, synonymous-codon, missense
rs11550402 -- 81,900,042(+) GCCGC(A/C)AGGAA reference, synonymous-codon, missense
rs11550404 -- 81,894,578(+) ATGCT(G/T)CCCTG reference, missense
rs11550405 -- 81,899,937(-) GCAGT(C/T)GTCGC reference, synonymous-codon, missense

Structural Variations from Database of Genomic Variants (DGV) for ANAPC11 Gene

Variant ID Type Subtype PubMed ID
nsv909052 CNV Loss 21882294
nsv428351 CNV Gain 18775914
dgv3330n71 CNV Loss 21882294
dgv3332n71 CNV Loss 21882294
nsv470620 CNV Loss 18288195
dgv3333n71 CNV Loss 21882294
nsv909134 CNV Loss 21882294
esv21913 CNV Gain+Loss 19812545
nsv909128 CNV Gain+Loss 21882294
nsv833569 CNV Loss 17160897
dgv3337n71 CNV Loss 21882294
dgv3338n71 CNV Loss 21882294
dgv3339n71 CNV Loss 21882294
nsv909151 CNV Gain+Loss 21882294
dgv3340n71 CNV Loss 21882294
dgv3341n71 CNV Loss 21882294
dgv3342n71 CNV Loss 21882294
esv29964 CNV Loss 17803354
esv33468 CNV Loss 17666407

Variation tolerance for ANAPC11 Gene

Residual Variation Intolerance Score: 64.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.71; 15.01% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ANAPC11 Gene

HapMap Linkage Disequilibrium report
ANAPC11

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ANAPC11 Gene

Disorders for ANAPC11 Gene

Relevant External Links for ANAPC11

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ANAPC11

No disorders were found for ANAPC11 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ANAPC11 Gene

Publications for ANAPC11 Gene

  1. The RING-H2 finger protein APC11 and the E2 enzyme UBC4 are sufficient to ubiquitinate substrates of the anaphase-promoting complex. (PMID: 10922056) Gmachl M. … Peters J.-M. (Proc. Natl. Acad. Sci. U.S.A. 2000) 2 3 4 67
  2. The RING-H2-finger protein APC11 as a target of hydrogen peroxide. (PMID: 15256223) Chang T.S. … Rhee S.G. (Free Radic. Biol. Med. 2004) 3 23
  3. Molecular cloning and characterization of a RING-H2 finger protein, ANAPC11, the human homolog of yeast Apc11p. (PMID: 11573242) Chan A.H. … Tsui S.K.W. (J. Cell. Biochem. 2001) 3 23
  4. ROC1, a homolog of APC11, represents a family of cullin partners with an associated ubiquitin ligase activity. (PMID: 10230407) Ohta T. … Xiong Y. (Mol. Cell 1999) 3 23
  5. Deregulation of Rb-E2F1 axis causes chromosomal instability by engaging the transactivation function of Cdc20-anaphase-promoting complex/cyclosome. (PMID: 25368385) Nath S. … Roychoudhury S. (Mol. Cell. Biol. 2015) 3

Products for ANAPC11 Gene

Sources for ANAPC11 Gene

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