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ANAPC11 Gene

protein-coding   GIFtS: 61
GCID: GC17P079849

Anaphase Promoting Complex Subunit 11

(Previous name: anaphase promoting complex subunit 11 (yeast APC11 homolog))
  See ANAPC11-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Anaphase Promoting Complex Subunit 111 2     Hepatocellular Carcinoma-Associated RING Finger Protein2 3
APC112 3 5     Apc11p2
Anaphase Promoting Complex Subunit 11 (Yeast APC11 Homolog)1 2     Anaphase-Promoting Complex Subunit 112
Cyclosome Subunit 112 3     APC11 Anaphase Promoting Complex Subunit 11 Homolog2

External Ids:    HGNC: 144521   Entrez Gene: 515292   Ensembl: ENSG000001415527   OMIM: 6145345   UniProtKB: Q9NYG53   

Export aliases for ANAPC11 gene to outside databases

Previous GC identifers: GC17P079341 GC17P9I0152 GC17P080384 GC17P077442 GC17P075220


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for ANAPC11 Gene:
ANAPC11 (anaphase promoting complex subunit 11) is a protein-coding gene. Diseases associated with ANAPC11 include hepatocellular carcinoma. GO annotations related to this gene include ubiquitin-protein ligase activity.

UniProtKB/Swiss-Prot: APC11_HUMAN, Q9NYG5
Function: Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin
ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by
mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of
'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked
polyubiquitin chains. May recruit the E2 ubiquitin-conjugating enzymes to the complex

Gene Wiki entry for ANAPC11 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000017.10  NC_018928.2  NT_010663.16  
Regulatory elements:
   Regulatory transcription factor binding sites in the ANAPC11 gene promoter:
         CUTL1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): ANAPC11 promoter sequence
   Search Chromatin IP Primers for ANAPC11

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ANAPC11


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q25.3   Ensembl cytogenetic band:  17q25.3   HGNC cytogenetic band: 17q25.3

ANAPC11 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ANAPC11 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17P079849:  view genomic region     (about GC identifiers)

Start:
79,848,666 bp from pter      End:
79,858,867 bp from pter
Size:
10,202 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: APC11_HUMAN, Q9NYG5 (See protein sequence)
Recommended Name: Anaphase-promoting complex subunit 11  
Size: 84 amino acids; 9841 Da
Subunit: The APC/C is composed of at least 12 subunits. Interacts with the cullin domain of ANAPC2. Interacts with
UBE2D2
Sequence caution: Sequence=AAF36134.1; Type=Frameshift; Positions=67;
Secondary accessions: A8MTT2 B7ZW64 Q502X9 Q9BW64 Q9P0R2
Alternative splicing: 2 isoforms:  Q9NYG5-1   Q9NYG5-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for ANAPC11: NX_Q9NYG5

Explore proteomics data for ANAPC11 at MOPED

Post-translational modifications: 

  • Auto-ubiquitinated1
  • Ubiquitination2 at Lys6
  • Modification sites at PhosphoSitePlus

  • See ANAPC11 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (14 alternative transcripts): 
    NP_001002244.1  NP_001002245.1  NP_001002246.1  NP_001002247.1  NP_001002248.1  NP_001002249.1  NP_001276343.1  NP_001276344.1  
    NP_001276345.1  NP_001276346.1  NP_001276347.1  NP_001276348.1  NP_001276349.1  NP_057560.8  

    ENSEMBL proteins: 
     ENSP00000458143   ENSP00000460678   ENSP00000463640   ENSP00000339695   ENSP00000464403  
     ENSP00000462691   ENSP00000461648   ENSP00000460064   ENSP00000458265   ENSP00000349957  
     ENSP00000462250   ENSP00000459200   ENSP00000464615   ENSP00000463567   ENSP00000463889  
     ENSP00000376181   ENSP00000464519   ENSP00000463598   ENSP00000463357   ENSP00000458515  
     ENSP00000462527  
    Reactome Protein details: Q9NYG5

    ANAPC11 Human Recombinant Protein Products:

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    Novus Biologicals ANAPC11 Proteins
    Novus Biologicals ANAPC11 Lysates
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    Cloud-Clone Corp. Proteins for ANAPC11

     
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    antibodies-online proteins for ANAPC11 (7 products) 

     
    antibodies-online peptides for ANAPC11

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ANAPC: Anaphase promoting complex subunits

    3 InterPro protein domains:
     IPR024991 Apc11
     IPR001841 Znf_RING
     IPR013083 Znf_RING/FYVE/PHD

    Graphical View of Domain Structure for InterPro Entry Q9NYG5

    ProtoNet protein and cluster: Q9NYG5

    1 Blocks protein domain: IPB001841 Zn-finger

    UniProtKB/Swiss-Prot: APC11_HUMAN, Q9NYG5
    Domain: The RING-type zinc finger domain coordinates an additional third zinc ion
    Similarity: Belongs to the RING-box family
    Similarity: Contains 1 RING-type zinc finger


    Find genes that share domains with ANAPC11           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: APC11_HUMAN, Q9NYG5
    Function: Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin
    ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by
    mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of
    'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked
    polyubiquitin chains. May recruit the E2 ubiquitin-conjugating enzymes to the complex

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004842contributes to ubiquitin-protein ligase activity IDA11739784
    GO:0005515protein binding ----
    GO:0008270zinc ion binding IEA--
         
    Find genes that share ontologies with ANAPC11           About GenesLikeMe


    Phenotypes:
         4 GenomeRNAi human phenotypes for ANAPC11:
     Cell division defect  Increased S DNA content, incre  Increased cell death HMECs cel  Increased gamma-H2AX phosphory 

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for ANAPC11

    miRNA
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    miRTarBase miRNAs that target ANAPC11:
    hsa-mir-100-5p (MIRT048482)

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    7 qRT-PCR Assays for microRNAs that regulate ANAPC11:
    hsa-miR-433 hsa-miR-505 hsa-miR-548t hsa-miR-1261 hsa-miR-766 hsa-miR-664 hsa-miR-338-3p
    SwitchGear 3'UTR luciferase reporter plasmidANAPC11 3' UTR sequence
    Inhib. RNA
    Products:
        
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    Predesigned siRNA for gene silencing in human, mouse, rat ANAPC11

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    GenScript: all cDNA clones in your preferred vector (see all 7): ANAPC11 (NM_001002244)
    Sino Biological Human cDNA Clone for ANAPC11
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ANAPC11
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ANAPC11
    Addgene plasmids for ANAPC11 

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ANAPC11


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    APC11_HUMAN, Q9NYG5: Cytoplasm. Nucleus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol4
    extracellular3

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005654nucleoplasm TAS--
    GO:0005680anaphase-promoting complex IDA11739784
    GO:0005730NOT nucleolus IDA--
    GO:0005829cytosol TAS--

    Find genes that share ontologies with ANAPC11           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for ANAPC11 About   (see all 21)  
    See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1Inactivation of APC/C via direct inhibition of the APC/C complex
    Inactivation of APC/C via direct inhibition of the APC/C complex0.64
    Mitotic Spindle Checkpoint0.62
    APC/C-Cdc20 mediated degradation of Cyclin B0.64
    Common schema of ubiquitination0.33
    Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components0.64
    2Class I MHC mediated antigen processing and presentation
    Class I MHC mediated antigen processing and presentation0.84
    Adaptive Immune System0.41
    Antigen processing- Ubiquitination and Proteasome degradation0.84
    Ubiquitin mediated proteolysis0.35
    3CDK-mediated phosphorylation and removal of Cdc6
    APC/C-mediated degradation of cell cycle proteins0.94
    Activation of APC/C and APC/C-Cdc20 mediated degradation of mitotic proteins0.92
    Regulation of mitotic cell cycle0.94
    Autodegradation of Cdh1 by Cdh1-APC/C0.91
    Regulation of APC/C activators between G1/S and early anaphase0.94
    Cell Cycle Checkpoints0.58
    APC/C-Cdc20 mediated degradation of Securin0.93
    Phosphorylation of the APC/C0.00
    4Mitotic Metaphase and Anaphase
    Mitotic Anaphase0.94
    Mitotic Metaphase and Anaphase0.93
    Separation of Sister Chromatids0.94
    5Cell Cycle, Mitotic
    Cell Cycle, Mitotic0.90
    M Phase0.62
    Cell Cycle0.90


    Find genes that share SuperPaths with ANAPC11           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for ANAPC11 (see all 6)
        Activation of PKA through GPCR
    Remodeling of Adherens Junctions
    cAMP Pathway
    CDC42 Pathway
    Mitotic Roles of Polo Like Kinases

    Selected GeneGo (Thomson Reuters) Pathways for ANAPC11 (see all 7)
        Cell cycle Role of APC in cell cycle regulation
    G-protein signaling G-Protein alpha-s signaling cascades
    Signal transduction PKA signaling
    Cell cycle Regulation of G1/S transition (part 1)
    Cell cycle Spindle assembly and chromosome separation


    Selected Reactome Pathways for ANAPC11 (see all 12)
        APC/C:Cdc20 mediated degradation of mitotic proteins
    Autodegradation of Cdh1 by Cdh1:APC/C
    Phosphorylation of the APC/C
    Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase
    APC/C:Cdc20 mediated degradation of Securin


    5 Kegg Pathways  (Kegg details for ANAPC11):
        Cell cycle
    Oocyte meiosis
    Ubiquitin mediated proteolysis
    Progesterone-mediated oocyte maturation
    HTLV-I infection

    UniProtKB/Swiss-Prot: APC11_HUMAN, Q9NYG5
    Pathway: Protein modification; protein ubiquitination

        Pathway & Disease-focused RT2 Profiler PCR Arrays including ANAPC11: 

              Ubiquitination (Ubiquitylation) Pathway in human mouse rat
              Ubiquitin Ligases in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for ANAPC11

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for ANAPC11 (Q9NYG53 ENSP000003499574) via UniProtKB, MINT, STRING, and/or I2D (see all 122)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    UBE2UQ5VVX93, ENSP000003601164I2D: score=2 STRING: ENSP00000360116
    ANAPC1Q9H1A43, ENSP000003391094I2D: score=1 STRING: ENSP00000339109
    CCNB1P146353, ENSP000002564424I2D: score=1 STRING: ENSP00000256442
    PTTG1O959973, ENSP000003449364I2D: score=1 STRING: ENSP00000344936
    CDC16Q130423, ENSP000003485544I2D: score=2 STRING: ENSP00000348554
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000278mitotic cell cycle TAS--
    GO:0007067mitosis TAS11739784
    GO:0007094mitotic spindle assembly checkpoint TAS--
    GO:0016567protein ubiquitination IDA11739784
    GO:0031145anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process TAS--

    Find genes that share ontologies with ANAPC11           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
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    Browse Tocris compounds for ANAPC11 (APC11)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for ANAPC11 gene (14 alternative transcripts): 
    NM_001002244.2  NM_001002245.2  NM_001002246.2  NM_001002247.2  NM_001002248.2  NM_001002249.2  NM_001289414.1  NM_001289415.1  
    NM_001289416.1  NM_001289417.1  NM_001289418.1  NM_001289419.1  NM_001289420.1  NM_016476.11  

    Unigene Cluster for ANAPC11:

    Anaphase promoting complex subunit 11
    Hs.534456  [show with all ESTs]
    Unigene Representative Sequence: BQ961272
    Selected Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 22):
    ENST00000571570 ENST00000572639 ENST00000579978 ENST00000344877(uc002kbv.1 uc002kbw.1 uc002kbx.1 uc002kbz.1 uc002kca.1 uc002kcb.1 uc002kcc.1)
    ENST00000582222 ENST00000577425 ENST00000571024 ENST00000574924 ENST00000572851
    ENST00000357385(uc002kby.1) ENST00000584314 ENST00000571874 ENST00000578550
    ENST00000577747 ENST00000579133 ENST00000392376 ENST00000584197 ENST00000583839

    miRNA
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    7 qRT-PCR Assays for microRNAs that regulate ANAPC11:
    hsa-miR-433 hsa-miR-505 hsa-miR-548t hsa-miR-1261 hsa-miR-766 hsa-miR-664 hsa-miR-338-3p
    SwitchGear 3'UTR luciferase reporter plasmidANAPC11 3' UTR sequence
    Inhib. RNA
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    Addgene plasmids for ANAPC11 
    Primer
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      QuantiTect SYBR Green Assays in human, mouse, rat ANAPC11
      QuantiFast Probe-based Assays in human, mouse, rat ANAPC11

    Additional mRNA sequence: 

    AF151048.1 AF247565.1 AF247789.1 AK307214.1 AK308091.1 BC000607.1 BC066308.1 BC095454.1 
    BC104641.1 BC171892.1 BC171898.1 BC171899.1 BC171900.1 

    24 DOTS entries:

    DT.100826159  DT.100826158  DT.100800423  DT.100826161  DT.86847246  DT.97815021  DT.92437366  DT.95198886 
    DT.92437369  DT.95345705  DT.100826160  DT.95345698  DT.100038051  DT.120912355  DT.95196802  DT.113574 
    DT.120912329  DT.99942502  DT.99971063  DT.120912279  DT.92437359  DT.92437365  DT.95345732  DT.97859422 

    Selected AceView cDNA sequences (see all 123):

    AI423863 AI452979 BM785773 AI299722 BM854462 AI088790 AI085289 AI343405 
    AI934760 BM782350 BU957767 AI809223 AI523869 BF446070 AI378380 BQ919512 
    AI824093 AI206071 BU624466 BF512771 AI283498 AF086513 BM782652 BM766572 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for ANAPC11 (see all 17)    About this scheme

    ExUns: 1 ^ 2a · 2b · 2c · 2d · 2e · 2f ^ 3a · 3b · 3c ^ 4 ^ 5 ^ 6a · 6b · 6c · 6d ^ 7 ^ 8a · 8b · 8c · 8d · 8e · 8f
    SP1:                                      -     -     -     -                 -           -     -     -                                       
    SP2:                                -     -     -     -     -                 -           -     -     -                                       
    SP3:        -     -     -     -     -     -     -     -     -     -           -           -     -     -                                       
    SP4:                                      -     -     -     -     -           -           -     -     -                                       
    SP5:                                -     -     -     -     -     -           -           -     -     -                                       


    ECgene alternative splicing isoforms for ANAPC11

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

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    ANAPC11 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CTGGCGCCGA
    ANAPC11 Expression
    About this image


    ANAPC11 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 10) fully expand
     
     Bone (Muscoskeletal System)
             Bone Marrow
     
     Colon (Gastrointestinal Tract)
     
     Kidney (Urinary System)
     
     Thyroid (Endocrine System)
     
     Testis (Reproductive System)
    ANAPC11 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ANAPC11 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.534456

    UniProtKB/Swiss-Prot: APC11_HUMAN, Q9NYG5
    Tissue specificity: Expressed at high levels in skeletal muscle and heart; in moderate levels in brain, kidney,
    and liver; and at low levels in colon, thymus, spleen, small intestine, placenta, lung and peripheral blood
    leukocyte

        Pathway & Disease-focused RT2 Profiler PCR Arrays including ANAPC11: 
              Ubiquitination (Ubiquitylation) Pathway in human mouse rat
              Ubiquitin Ligases in human mouse rat

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for ANAPC11 gene from Selected species (see all 18)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Anapc111 , 5 anaphase promoting complex subunit 111, 5 89.29(n)1
    98.81(a)1
      11 (84.32 cM)5
    661561  NM_001038230.21  NP_001033319.11 
     1205984215 
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia anapc111 anaphase promoting complex subunit 11 82.14(n)
    88.1(a)
      496610  NM_001011188.1  NP_001011188.1 
    zebrafish
    (Danio rerio)
    Actinopterygii anapc111 APC11 anaphase promoting complex subunit 11 homolog more 79.37(n)
    91.67(a)
      768140  NM_001098480.1  NP_001091950.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta lmg3
    lmgA1
    mitotic anaphase3
    lemming A1
    73(a)3
    74.7(n)1
    72.29(a)1
      29D43
    57408531  NM_001273333.11  NP_001260262.11 
    worm
    (Caenorhabditis elegans)
    Secernentea apc-116
    Protein APC-11 (apc-11) mRNA, complete cds
    16(a)
    1 ↔ 1
    III(4593769-4594426) WBGene00000145
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes APC11(YDL008W)4
    APC111
    Catalytic core subunit of the Anaphase-Promoting Complex/Cyclosome more4
    APC111
    54.76(n)1
    53.57(a)1
      4(433497-433994)4
    8515541, 4  NP_010276.31  NP_010276.14 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons APC111 APC11 61.79(n)
    68.29(a)
      819756  NM_001202890.1  NP_001189819.1 
    rice
    (Oryza sativa)
    Liliopsida Os07g04111011 Os07g0411101 69.88(n)
    69.88(a)
      9272104  NM_001188229.1  NP_001175158.1 


    ENSEMBL Gene Tree for ANAPC11 (if available)
    TreeFam Gene Tree for ANAPC11 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for ANAPC11 gene
    12 SIMAP similar genes for ANAPC11 using alignment to 4 protein entries:     APC11_HUMAN (see all proteins):
    IPO7    NSRP1    ZNF738    COX7A2    LRRC36    MKRN1
    UTY    ZNF568    ZNHIT3    IFT122    RNF7    RBX1

    Find genes that share paralogs with ANAPC11           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ANAPC11 (see all 169)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1836900891,2
    --79851489(+) ACGTGA/GGGTAA 7 -- ut51 int10--------
    rs1872742311,2
    --79851564(+) CTTCCC/TTTGGA 7 -- int10--------
    rs2020919591,2
    C--79851621(+) TAGTTC/TTTTTT 7 -- int10--------
    rs724431491,2
    C--79851632(+) TTTCC-/T/TT  
            
    TTTTT
    7 -- int10--------
    rs1494777421,2
    --79851718(+) TCCTCC/GCGAGT 7 -- int10--------
    rs1917466761,2
    --79851719(+) CCTCCC/TGAGTT 7 -- int10--------
    rs1447966341,2
    --79851876(+) ATAGCA/GGGGCA 7 -- int10--------
    rs1481303511,2
    C--79851885(+) CATAGG/TGGTTC 7 -- int10--------
    rs1420121941,2
    C--79851921(+) AGGCCA/GCAGTG 7 -- int10--------
    rs1473140391,2
    C--79852008(+) TTAGTC/TGGGCG 7 -- int10--------

    HapMap Linkage Disequilibrium report for ANAPC11 (79848666 - 79858867 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for ANAPC11 (see all 19):    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv909134CNV Loss21882294
    dgv3341n71CNV Loss21882294
    dgv3333n71CNV Loss21882294
    nsv833569CNV Loss17160897
    esv29964CNV Loss17803354
    dgv3340n71CNV Loss21882294
    dgv3332n71CNV Loss21882294
    dgv3342n71CNV Loss21882294
    dgv3338n71CNV Loss21882294
    esv33468CNV Loss17666407

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing ANAPC11
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 614534    OMIM disorders: --

    1 disease for ANAPC11:    
    About MalaCards
    hepatocellular carcinoma


    Find genes that share disorders with ANAPC11           About GenesLikeMe


    Export disorders for ANAPC11 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ANAPC11 gene, integrated from 10 sources (see all 60):
    (articles sorted by number of sources associating them with ANAPC11)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The RING-H2 finger protein APC11 and the E2 enzyme UBC4 are sufficient to ubiquitinate substrates of the anaphase-promoting complex. (PubMed id 10922056)1, 2, 3 Gmachl M.... Peters J.-M. (Proc. Natl. Acad. Sci. U.S.A. 2000)
    2. Molecular cloning and characterization of a RING-H2 finger protein, ANAPC11, the human homolog of yeast Apc11p. (PubMed id 11573242)1, 2, 9 Chan A.H.... Tsui S.K.W. (J. Cell. Biochem. 2001)
    3. Mechanism of ubiquitin-chain formation by the human anaphase- promoting complex. (PubMed id 18485873)1, 2 Jin L.... Rape M. (Cell 2008)
    4. Localization of the coactivator Cdh1 and the cullin subunit Apc2 in a cryo-electron microscopy model of vertebrate APC/C. (PubMed id 16364912)1, 2 Dube P.... Stark H. (Mol. Cell 2005)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    6. APC2 cullin protein and APC11 RING protein comprise the minimal ubiquitin ligase module of the anaphase-promoting complex. (PubMed id 11739784)1, 2 Tang Z.... Yu H. (Mol. Biol. Cell 2001)
    7. Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. (PubMed id 11042152)1, 2 Zhang Q.-H.... Chen Z. (Genome Res. 2000)
    8. The RING-H2-finger protein APC11 as a target of hydrogen peroxide. (PubMed id 15256223)1, 9 Chang T.S....Rhee S.G. (amp 2004)
    9. ROC1, a homolog of APC11, represents a family of cullin partners with an associated ubiquitin ligase activity. (PubMed id 10230407)1, 9 Ohta T.... Xiong Y. (Mol. Cell 1999)
    10. Electron microscopy structure of human APC/C(CDH1)-EMI1 reveals multimodal mechanism of E3 ligase shutdown. (PubMed id 23708605)1 Frye J.J....Schulman B.A. (amp 2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 51529 HGNC: 14452 AceView: THOC4 Ensembl:ENSG00000141552 euGenes: HUgn51529
    ECgene: ANAPC11 Kegg: 51529 H-InvDB: ANAPC11

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for ANAPC11 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for ANAPC11 gene:
    Search GeneIP for patents involving ANAPC11

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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