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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ANAPC11 Gene

protein-coding   GIFtS: 59
GCID: GC17P079849

anaphase promoting complex subunit 11

(Previous name: anaphase promoting complex subunit 11 (yeast APC11 homolog)...)
 Explore 5 diseases affiliated with
ANAPC11 via our new
 Human Malady Compendium 
Biological research products
for ANAPC11
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
Anaphase Promoting Complex Subunit 111 2     Hepatocellular Carcinoma-Associated RING Finger Protein2 3
APC111 2 3     HSPC2141
Apc11p1 2     MGC8821
Anaphase Promoting Complex Subunit 11 (Yeast APC11 Homolog)1 2     Anaphase-Promoting Complex Subunit 112
Cyclosome Subunit 112 3     APC11 Anaphase Promoting Complex Subunit 11 Homolog2

External Ids:    HGNC: 144521   Entrez Gene: 515292   Ensembl: ENSG000001415527   OMIM: 6145345   UniProtKB: Q9NYG53   

Export aliases for ANAPC11 gene to outside databases

Previous GC identifers: GC17P079341 GC17P9I0152 GC17P080384 GC17P077442 GC17P075220


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: APC11_HUMAN, Q9NYG5
Function: Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase
that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating
ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked
polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. May
recruit the E2 ubiquitin-conjugating enzymes to the complex

Gene Wiki entry for ANAPC11


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000017.10  NC_018928.1  NT_010663.15  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ANAPC11 gene promoter:
         CUTL1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): ANAPC11 promoter sequence
   Search SABiosciences Chromatin IP Primers for ANAPC11

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ANAPC11


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q25.3   Ensembl cytogenetic band:  17q25.3   HGNC cytogenetic band: 17q25.3

ANAPC11 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ANAPC11 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17P079849:  view genomic region     (about GC identifiers)

Start:
79,848,666 bp from pter      End:
79,858,867 bp from pter
Size:
10,202 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: APC11_HUMAN, Q9NYG5 (See protein sequence)
Recommended Name: Anaphase-promoting complex subunit 11  
Size: 84 amino acids; 9841 Da
Subunit: The APC/C is composed of at least 12 subunits. Interacts with the cullin domain of ANAPC2. Interacts with
UBE2D2
Subcellular location: Cytoplasm. Nucleus
Sequence caution: Sequence=AAF36134.1; Type=Frameshift; Positions=67;
Secondary accessions: A8MTT2 B7ZW64 Q502X9 Q9BW64 Q9P0R2
Alternative splicing: 2 isoforms:  Q9NYG5-1   Q9NYG5-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for ANAPC11: NX_Q9NYG5

Post-translational modifications:

  • Auto-ubiquitinated1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q9NYG5

  • ANAPC11 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (7 alternative transcripts): 
    NP_001002244.1  NP_001002245.1  NP_001002246.1  NP_001002247.1  NP_001002248.1  NP_001002249.1  NP_057560.8  

    ENSEMBL proteins: 
     ENSP00000458143   ENSP00000460678   ENSP00000463640   ENSP00000339695   ENSP00000464403  
     ENSP00000462691   ENSP00000461648   ENSP00000460064   ENSP00000458265   ENSP00000349957  
     ENSP00000462250   ENSP00000459200   ENSP00000464615   ENSP00000463567   ENSP00000463889  
     ENSP00000376181   ENSP00000464519   ENSP00000463598   ENSP00000463357   ENSP00000458515  
     ENSP00000462527  
    Reactome Protein details: Q9NYG5
    Human Recombinant Protein Products: 
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    Uscn Proteins for ANAPC11

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005654nucleoplasm TAS--
    GO:0005680anaphase-promoting complex IDA--
    GO:0005829cytosol TAS--


    ANAPC11 for ontologies           About GeneDecksing



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    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    ANAPC11 for domains           About GeneDecksing

    3 InterPro domains/families:
     IPR024991 Apc11
     IPR001841 Znf_RING
     IPR013083 Znf_RING/FYVE/PHD

    Graphical View of Domain Structure for InterPro Entry Q9NYG5

    ProtoNet protein and cluster: Q9NYG5

    1 Blocks protein family: IPB001841 Zn-finger

    UniProtKB/Swiss-Prot: APC11_HUMAN, Q9NYG5
    Domain: The RING-type zinc finger domain coordinates an additional third zinc ion
    Similarity: Belongs to the RING-box family
    Similarity: Contains 1 RING-type zinc finger


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    Function Summary:

         UniProtKB/Swiss-Prot: APC11_HUMAN, Q9NYG5
    Function: Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase
    that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating
    ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked
    polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. May
    recruit the E2 ubiquitin-conjugating enzymes to the complex

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    hsa-miR-433 hsa-miR-505 hsa-miR-548t hsa-miR-1261 hsa-miR-766 hsa-miR-664 hsa-miR-338-3p
    SwitchGear 3'UTR luciferase reporter plasmidANAPC11 3' UTR sequence
    Inhib. RNA
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    Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004842contributes to ubiquitin-protein ligase activity IDA11739784
    GO:0008270zinc ion binding IEA--


    ANAPC11 for ontologies           About GeneDecksing


    4 GenomeRNAi human phenotypes for ANAPC11:
     Cell division defect  Increased S DNA content, incre  Increased cell death HMECs cel  Increased gamma-H2AX phosphory 


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/21 super-pathways (see all 21About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Ubiquitinated Orc1 is degraded by the proteasome
    8/15 pathways (see all 15)
    APC/C:Cdh1-mediated degradation of Skp20.74
    APC/C:Cdc20 mediated degradation of mitotic proteins0.69
    APC/C:Cdc20 mediated degradation of Securin0.74
    APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G10.69
    Degradation of multiubiquitinated Securin0.74
    Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins0.68
    Autodegradation of Cdh1 by Cdh1:APC/C0.70
    Regulation of APC/C activators between G1/S and early anaphase0.62
    2APC-Cdc20 mediated degradation of Nek2A
    8/10 pathways (see all 10)
    Degradation of multiubiquitinated Nek2A1.00
    Degradation of multiubiquitinated Cyclin B0.76
    APC-Cdc20 mediated degradation of Nek2A1.00
    Mitotic Spindle Checkpoint0.75
    Inactivation of APC/C via direct inhibition of the APC/C complex0.78
    Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase0.60
    Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components0.78
    Phosphorylation of the APC/C0.54
    3M Phase
    M Phase1.00
    Mitotic Anaphase0.85
    Mitotic M-M/G1 phases0.88
    Separation of Sister Chromatids0.80
    Mitotic Metaphase and Anaphase0.85
    4Antigen processing: Ubiquitination & Proteasome degradation
    Antigen processing: Ubiquitination & Proteasome degradation1.00
    Polyubiquitination of substrate0.75
    Class I MHC mediated antigen processing & presentation0.83
    Ubiquitin mediated proteolysis0.36
    5Cell cycle_Spindle assembly and chromosome separation
    Cell cycle_Spindle assembly and chromosome separation1.00
    Cell cycle Spindle assembly and chromosome separation0.94

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    5/9 EMD Millipore Pathways for ANAPC11 (see all 9)
        Cell cycle Role of APC in cell cycle regulation
    Meiosis
    Cell cycle Regulation of G1/S transition (part 1)
    Development TGF-beta receptor signaling
    Signal transduction PKA signaling

    5/6 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for ANAPC11 (see all 6)
        Activation of PKA through GPCR
    Remodeling of Adherens Junctions
    cAMP Pathway
    CDC42 Pathway
    Mitotic Roles of Polo Like Kinases

    5/7 GeneGo (Thomson Reuters) Pathways for ANAPC11 (see all 7)
        Cell cycle Role of APC in cell cycle regulation
    G-protein signaling G-Protein alpha-s signaling cascades
    Signal transduction PKA signaling
    Cell cycle Regulation of G1/S transition (part 1)
    Cell cycle Spindle assembly and chromosome separation

    5/36        Reactome Pathways for ANAPC11 (see all 36)
        APC/C:Cdc20 mediated degradation of mitotic proteins
    Phosphorylation of the APC/C
    APC/C:Cdc20 mediated degradation of Securin
    Cdc20:Phospho-APC/C mediated degradation of Cyclin A
    Antigen processing: Ubiquitination & Proteasome degradation


    4         Kegg Pathways  (Kegg details for ANAPC11):
        Cell cycle
    Oocyte meiosis
    Ubiquitin mediated proteolysis
    Progesterone-mediated oocyte maturation

    UniProtKB/Swiss-Prot: APC11_HUMAN, Q9NYG5
    Pathway: Protein modification; protein ubiquitination


    ANAPC11 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for ANAPC11

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/107 Interacting proteins for ANAPC11 (Q9NYG53 ENSP000003499574) via UniProtKB, MINT, STRING, and/or I2D (see all 107)

    InteractantInteraction Details
    GeneCardExternal ID(s)
    UBE2UQ5VVX93, ENSP000003601164I2D: score=2 STRING: ENSP00000360116
    ANAPC1Q9H1A43, ENSP000003391094I2D: score=1 STRING: ENSP00000339109
    CCNB1P146353, ENSP000002564424I2D: score=1 STRING: ENSP00000256442
    PTTG1O959973, ENSP000003449364I2D: score=1 STRING: ENSP00000344936
    CDC16Q130423, ENSP000003485544I2D: score=2 STRING: ENSP00000348554
    About this table

    Gene Ontology (GO): 5/11 biological process terms (GO ID links to tree view) (see all 11):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000075cell cycle checkpoint TAS--
    GO:0000278mitotic cell cycle TAS--
    GO:0007067mitosis TAS11739784
    GO:0007094mitotic cell cycle spindle assembly checkpoint TAS--
    GO:0016567protein ubiquitination IDA11739784


    ANAPC11 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ANAPC11
    Search CenterWatch for drugs/clinical trials and news about ANAPC11 / APC11 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for ANAPC11 gene (7 alternative transcripts): 
    NM_001002244.1  NM_001002245.1  NM_001002246.1  NM_001002247.1  NM_001002248.1  NM_001002249.1  NM_016476.10  

    Unigene Cluster for ANAPC11:

    Anaphase promoting complex subunit 11
    Hs.534456  [show with all ESTs]
    Unigene Representative Sequence: BQ961272
    18/22 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 22):
    ENST00000571570 ENST00000572639 ENST00000579978 ENST00000344877(uc002kbv.1 uc002kbw.1 uc002kbx.1 uc002kbz.1 uc002kca.1 uc002kcb.1 uc002kcc.1)
    ENST00000582222 ENST00000577425 ENST00000571024 ENST00000574924 ENST00000572851
    ENST00000357385(uc002kby.1) ENST00000584314 ENST00000571874 ENST00000578550
    ENST00000577747 ENST00000579133 ENST00000392376 ENST00000584197 ENST00000583839


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    Inhib. RNA
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    Additional cDNA sequence: 

    AF151048.1 AF247565.1 AF247789.1 AK307214.1 AK308091.1 BC000607.1 BC066308.1 BC095454.1 
    BC104641.1 BC171892.1 BC171898.1 BC171899.1 BC171900.1 

    24 DOTS entries:

    DT.100826159  DT.100826158  DT.100800423  DT.100826161  DT.86847246  DT.97815021  DT.92437366  DT.95198886 
    DT.92437369  DT.95345705  DT.100826160  DT.95345698  DT.100038051  DT.120912355  DT.95196802  DT.113574 
    DT.120912329  DT.99942502  DT.99971063  DT.120912279  DT.92437359  DT.92437365  DT.95345732  DT.97859422 

    24/123 AceView cDNA sequences (see all 123):

    BF446070 BU957767 BM785773 AI523869 AI452979 AI085289 AI285920 AI809223 
    AW082296 AI343405 AI934760 BM782350 AI423863 BM854462 AI243940 AI299722 
    AI088790 BM784649 BU538782 BM766572 BM782652 AF086513 AI824093 BF512771 

    GeneLoc Exon Structure

    5/17 Alternative Splicing Database (ASD) splice patterns (SP) for ANAPC11 (see all 17)    About this scheme

    ExUns: 1 ^ 2a · 2b · 2c · 2d · 2e · 2f ^ 3a · 3b · 3c ^ 4 ^ 5 ^ 6a · 6b · 6c · 6d ^ 7 ^ 8a · 8b · 8c · 8d · 8e · 8f
    SP1:                                      -     -     -     -                 -           -     -     -                                       
    SP2:                                -     -     -     -     -                 -           -     -     -                                       
    SP3:        -     -     -     -     -     -     -     -     -     -           -           -     -     -                                       
    SP4:                                      -     -     -     -     -           -           -     -     -                                       
    SP5:                                -     -     -     -     -     -           -           -     -     -                                       


    ECgene alternative splicing isoforms for ANAPC11

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ANAPC11 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: CTGGCGCCGA

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)

    About this image
    See ANAPC11 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ANAPC11

    SOURCE GeneReport for Unigene cluster: Hs.534456

    UniProtKB/Swiss-Prot: APC11_HUMAN, Q9NYG5
    Tissue specificity: Expressed at high levels in skeletal muscle and heart; in moderate levels in brain, kidney, and
    liver; and at low levels in colon, thymus, spleen, small intestine, placenta, lung and peripheral blood leukocyte

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              Ubiquitination (Ubiquitylation) Pathway in human mouse rat
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for ANAPC11 gene from 6/16 species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Anapc111 , 5 anaphase promoting complex subunit 111, 5 89.29(n)1
    98.81(a)1
      11 (84.32 cM)5
    661561  NM_001038230.21  NP_001033319.11 
     1205984215 
    zebrafish
    (Danio rerio)
    Actinopterygii anapc111 APC11 anaphase promoting complex subunit 11 homolog more 79.37(n)
    91.67(a)
      768140  NM_001098480.1  NP_001091950.1 
    mosquito
    (Anopheles gambiae)
    Insecta AgaP_AGAP0081961 AGAP008196-PA 76.32(n)
    77.63(a)
      1277775  XM_317272.3  XP_317272.3 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes APC11(YDL008W)4
    APC111
    Catalytic core subunit of the Anaphase-Promoting Complex/Cyclosome more4
    Apc11p1
    54.76(n)1
    53.57(a)1
      4(433497-433994)4
    8515541, 4  NP_010276.31  NP_010276.14 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons APC111 anaphase-promoting complex subunit 11 63.89(n)
    71.43(a)
      819756  NM_001202890.1  NP_001189819.1 
    rice
    (Oryza sativa)
    Liliopsida Os07g04111011 hypothetical protein 69.88(n)
    69.88(a)
      9272104  NM_001188229.1  NP_001175158.1 


    ENSEMBL Gene Tree for ANAPC11 (if available)
    TreeFam Gene Tree for ANAPC11 (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/140 NCBI SNPs in ANAPC11 are shown (see all 140    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1836900891,2
    --79851489(+) ACGTGA/GGGTAA 7 -- ut51 int10--------
    rs1872742311,2
    --79851564(+) CTTCCC/TTTGGA 7 -- int10--------
    rs2020919591,2
    C--79851621(+) TAGTTC/TTTTTT 7 -- int10--------
    rs1494777421,2
    --79851718(+) TCCTCC/GCGAGT 7 -- int10--------
    rs1917466761,2
    --79851719(+) CCTCCC/TGAGTT 7 -- int10--------
    rs1447966341,2
    --79851876(+) ATAGCA/GGGGCA 7 -- int10--------
    rs1481303511,2
    --79851885(+) CATAGG/TGGTTC 7 -- int10--------
    rs1420121941,2
    --79851921(+) AGGCCA/GCAGTG 7 -- int10--------
    rs1473140391,2
    --79852008(+) TTAGTC/TGGGCG 7 -- int10--------
    rs1120845951,2
    --79852047(+) CTCAGC/GAGGCC 7 -- int11Minor allele frequency- G:0.00CSA 1

    HapMap Linkage Disequilibrium report for ANAPC11 (79848666 - 79858867 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 5 variations for ANAPC11
         5 CNVs: 23319 30036 7175 73078 5041

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    ANAPC11 for disorders           About GeneDecksing

    OMIM gene information: 614534    OMIM disorders: --

    5 diseases for ANAPC11:    About MalaCards
    hepatocellular carcinoma    molluscum contagiosum    carcinoma    intrahepatic cholangiocarcinoma
    cholangiocarcinoma


    Export disorders for ANAPC11 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ANAPC11 gene, integrated from 9 sources (see all 49):
    (articles sorted by number of sources associating them with ANAPC11)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The RING-H2 finger protein APC11 and the E2 enzyme UBC4 are sufficient to ubiquitinate substrates of the anaphase-promoting complex. (PubMed id 10922056)1, 2, 3 Gmachl M....Peters J.M. (2000)
    2. Molecular cloning and characterization of a RING-H2 finger protein, ANAPC11, the human homolog of yeast Apc11p. (PubMed id 11573242)1, 2, 9 Chan A.H.... Tsui S.K.W. (2001)
    3. Mechanism of ubiquitin-chain formation by the human anaphase-promoting complex. (PubMed id 18485873)1, 2 Jin L....Rape M. (2008)
    4. Localization of the coactivator Cdh1 and the cullin subunit Apc2 in a cryo-electron microscopy model of vertebrate APC/C. (PubMed id 16364912)1, 2 Dube P.... Stark H. (2005)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    6. APC2 cullin protein and APC11 RING protein comprise the minimal ubiquitin ligase module of the anaphase-promoting complex. (PubMed id 11739784)1, 2 Tang Z.... Yu H. (2001)
    7. Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. (PubMed id 11042152)1, 2 Zhang Q.-H.... Chen Z. (2000)
    8. The RING-H2-finger protein APC11 as a target of hydrogen peroxide. (PubMed id 15256223)1, 9 Chang T.S....Rhee S.G. (2004)
    9. ROC1, a homolog of APC11, represents a family of cullin partners with an associated ubiquitin ligase activity. (PubMed id 10230407)1, 9 Ohta T.... Xiong Y. (1999)
    10. Recombinant expression, reconstitution and structure o f human anaphase-promoting complex (APC/C). (PubMed id 23078409)1 Zhang Z....Barford D. (2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
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      Query String
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    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 51529 HGNC: 14452 AceView: THOC4 Ensembl:ENSG00000141552 euGenes: HUgn51529
    ECgene: ANAPC11 Kegg: 51529 H-InvDB: ANAPC11

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ANAPC11 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for ANAPC11 gene:
    Search GeneIP for patents involving ANAPC11

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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