Aliases for ANAPC11 Gene
Aliases for ANAPC11 Gene
- Anaphase Promoting Complex Subunit 11 2 3 5
- Anaphase Promoting Complex Subunit 11 (Yeast APC11 Homolog) 2 3
- Hepatocellular Carcinoma-Associated RING Finger Protein 3 4
- Cyclosome Subunit 11 3 4
- APC11 3 4
- APC11 Anaphase Promoting Complex Subunit 11 Homolog 3
- Anaphase-Promoting Complex Subunit 11 3
- HSPC214 3
- Apc11p 3
External Ids for ANAPC11 Gene
- HGNC: 14452
- Entrez Gene: 51529
- Ensembl: ENSG00000141552
- OMIM: 614534
- UniProtKB: Q9NYG5
Previous GeneCards Identifiers for ANAPC11 Gene
- GC17P079341
- GC17P9I0152
- GC17P080384
- GC17P077442
- GC17P079849
- GC17P075220
Summaries for ANAPC11 Gene
GeneCards Summary for ANAPC11 Gene
ANAPC11 (Anaphase Promoting Complex Subunit 11) is a Protein Coding gene. Among its related pathways are G-protein signaling G-Protein alpha-i signaling cascades and APC-Cdc20 mediated degradation of Nek2A. GO annotations related to this gene include ubiquitin-protein transferase activity and ubiquitin-ubiquitin ligase activity.
UniProtKB/Swiss-Prot for ANAPC11 Gene
-
Together with the cullin protein ANAPC2, constitutes the catalytic component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of Lys-11-linked polyubiquitin chains and, to a lower extent, the formation of Lys-48- and Lys-63-linked polyubiquitin chains. May recruit the E2 ubiquitin-conjugating enzymes to the complex.
No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ANAPC11 Gene
Genomics for ANAPC11 Gene
Regulatory Elements for ANAPC11 Gene
Enhancers for ANAPC11 Gene
- Elite enhancer and/or Elite enhancer-gene association
Download GeneHancer data dump
Enhancers around ANAPC11 on UCSC Golden Path with GeneCards custom track
- Transcription factor binding sites by QIAGEN in the ANAPC11 gene promoter:
Regulatory Element Products
Genomic Location for ANAPC11 Gene
- Chromosome:
- 17
- Start:
- 81,890,790 bp from pter
- End:
- 81,900,991 bp from pter
- Size:
- 10,202 bases
- Orientation:
- Plus strand
Genomic View for ANAPC11 Gene
Genes around ANAPC11 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 17q25.3 by Ensembl
- 17q25.3 by Entrez Gene
- 17q25.3 by HGNC
ANAPC11 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for ANAPC11 Gene
Proteins for ANAPC11 Gene
-
Protein details for ANAPC11 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q9NYG5-APC11_HUMAN
- Recommended name:
- Anaphase-promoting complex subunit 11
- Protein Accession:
- Q9NYG5
- A8MTT2
- B7ZW64
- Q502X9
- Q9BW64
- Q9P0R2
Protein attributes for ANAPC11 Gene
- Size:
- 84 amino acids
- Molecular mass:
- 9841 Da
- Quaternary structure:
-
- The mammalian APC/C is composed of 14 distinct subunits that assemble into a complex of at least 19 chains with a combined molecular mass of around 1.2 MDa. Interacts with the cullin domain of ANAPC2. Interacts with UBE2D2.
- SequenceCaution:
-
- Sequence=AAF36134.1; Type=Frameshift; Positions=67; Evidence={ECO:0000305};
Three dimensional structures from OCA and Proteopedia for ANAPC11 Gene
Protein Expression for ANAPC11 Gene
Post-translational modifications for ANAPC11 Gene
- Auto-ubiquitinated.
- Ubiquitination at posLast=66
- Modification sites at PhosphoSitePlus
Other Protein References for ANAPC11 Gene
- ENSEMBL proteins:
-
- ENSP00000339695
- ENSP00000376181
- ENSP00000458143
- ENSP00000458265
- ENSP00000458515
- ENSP00000459200
- ENSP00000460064
- ENSP00000460678
- ENSP00000461648
- ENSP00000462250
- ENSP00000462527
- ENSP00000462691
- ENSP00000463357
- ENSP00000463567
- ENSP00000463598
- ENSP00000463640
- ENSP00000463889
- ENSP00000464403
- ENSP00000464519
- ENSP00000464615
- ENSP00000484031
- ENSP00000349957
- REFSEQ proteins:
Antibody Products
- Cell Signaling Technology (CST) Antibodies for ANAPC11 (APC11)
-
Custom Antibody ServicesOriGene Antibodies for ANAPC11
- R1503
- TA319928
- TA326323
- TA352969
- TA506300FM
- TA506300GM
- TA506300HM
- TA506300JM
- TA506321AM
- TA506321BM
- TA506321CM
- TA506321DM
- TA506321EM
- TA506321FM
- TA506321GM
- TA506321HM
- TA506321JM
- TA506323AM
- TA506323BM
- TA506323CM
- TA506323DM
- TA506323EM
- TA506323FM
- TA506323GM
- TA506323HM
- TA506323JM
- TA506323S
- TA506325AM
- TA506325BM
- TA506325CM
- TA506325DM
- TA506325EM
- TA506325FM
- TA506325GM
- TA506325HM
- TA506325JM
- TA506300EM
- TA506300DM
- TA506300CM
- TA506300BM
- TA506300AM
- TA506235JM
- TA506235HM
- TA506235GM
- TA506235FM
- TA506235EM
- TA506235DM
- TA506235CM
- TA506235BM
- TA506235AM
- CF506326
- TA506326
- CF506325
- TA506325
- CF506323
- TA506323
- CF506321
- TA506321
- CF506300
- TA506300
- CF506235
- TA506235
- Novus Biologicals Antibodies for ANAPC11
-
Abcam antibodies for ANAPC11
- Invitrogen Antibodies for ANAPC11
- Invitrogen Antibodies for ANAPC11
- antibodies-online Antibodies for ANAPC11: See all 61
- GeneTex ANAPC11 antibody for ANAPC11
-
Custom Antibody ServicesProSci Antibodies for ANAPC11
-
Santa Cruz Biotechnology (SCBT) Antibodies for ANAPC11
Protein Products
- Search Origene for MassSpec and Protein Over-expression Lysates for ANAPC11
- Origene Custom Protein Services for ANAPC11
- antibodies-online Proteins for ANAPC11: See all 10
- Search antibodies-online for peptides
- Search GeneTex for Proteins for ANAPC11
Assay Products
- antibodies-online Kits for ANAPC11: See all 8
No data available for DME Specific Peptides for ANAPC11 Gene
Domains & Families for ANAPC11 Gene
Gene Families for ANAPC11 Gene
Protein Domains for ANAPC11 Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for ANAPC11 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q9NYG5UniProtKB/Swiss-Prot:
APC11_HUMAN :- The RING-type zinc finger domain coordinates an additional third zinc ion.
- Belongs to the RING-box family.
- Domain:
-
- The RING-type zinc finger domain coordinates an additional third zinc ion.
- Family:
-
- Belongs to the RING-box family.
Function for ANAPC11 Gene
Molecular function for ANAPC11 Gene
- UniProtKB/Swiss-Prot Function:
- Together with the cullin protein ANAPC2, constitutes the catalytic component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of Lys-11-linked polyubiquitin chains and, to a lower extent, the formation of Lys-48- and Lys-63-linked polyubiquitin chains. May recruit the E2 ubiquitin-conjugating enzymes to the complex.
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0004842 | contributes_to ubiquitin-protein transferase activity | IDA | 11739784 |
| GO:0008270 | zinc ion binding | IEA | -- |
| GO:0034450 | ubiquitin-ubiquitin ligase activity | IDA | 10230407 |
| GO:0046872 | metal ion binding | IEA | -- |
| GO:0061630 | ubiquitin protein ligase activity | IDA | 10230407 |
Phenotypes for ANAPC11 Gene
- GenomeRNAi human phenotypes for ANAPC11:
-
- Increased viability
- Increased vaccinia virus (VACV) infection
- Increased gamma-H2AX phosphorylation
- Decreased viability
- Mildly decreased CFP-tsO45G cell surface transport
- Dynamic nuclei (hole, folded or small irregular)
- Decreased NF-kappaB reporter expression
- Increased G1 DNA content
- G0/1 arrest
- Effect on mitosis
- Increased cell death HMECs cells
- Decreased cell number
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for ANAPC11
-
-
ViGene Biosciences lentiviral particle packaged cDNA for ANAPC11 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for ANAPC11 gene
- Search ViGene Biosciences for ANAPC11
CRISPR Products
-
OriGene CRISPR knockouts for ANAPC11
-
Santa Cruz Biotechnology (SCBT) CRISPR for ANAPC11
- GenScript: Design CRISPR guide RNA sequences for ANAPC11
miRNA for ANAPC11 Gene
- miRTarBase miRNAs that target ANAPC11
miRNA Products
- Search ViGene Biosciences for ANAPC11
Inhibitory RNA Products
- Origene RNAi, siRNA, and shRNA products in human, mouse, rat for ANAPC11
- Browse OriGene Inhibitory RNA Products For ANAPC11
-
ViGene Biosciences ready-to-package AAV shRNAs for ANAPC11 gene
Clone Products
-
OriGene ORF clones in human for ANAPC11
- RC200097
- RC200097L1
- RC200097L2
- RG200097
- RC223841
- RC223841L1
- RC223841L2
- RG223841
- RC224653
- RC224653L1
- RC224653L2
- RG224653
- RC215606
- RC215606L1
- RC215606L2
- RG215606
- RC222619
- RC222619L1
- RC222619L2
- RG222619
- RC224701
- RC224701L1
- RC224701L2
- RG224701
- RC235519
- RC235520
- RG224537
- RC224537L2
- RC224537L1
- RC224537
- RC235988
- RC235546
- RC235545
- RC235522
- RC235521
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for ANAPC11
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- Addgene plasmids for ANAPC11
- VectorBuilder custom plasmid, inducible vectors for ANAPC11
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for ANAPC11
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Cell Line Products
-
ViGene Biosciences adenoviral particle packaged cDNA for ANAPC11 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for ANAPC11 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for ANAPC11 gene
Flow Cytometry Products
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ANAPC11 Gene
Localization for ANAPC11 Gene
Subcellular locations from UniProtKB/Swiss-Prot for ANAPC11 Gene
- Cytoplasm. Nucleus.
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| cytosol | 5 |
| extracellular | 3 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005634 | nucleus | IEA | -- |
| GO:0005654 | nucleoplasm | TAS | -- |
| GO:0005680 | anaphase-promoting complex | IDA,IEA | 11739784 |
| GO:0005730 | nucleolus | IDA | -- |
| GO:0005737 | cytoplasm | IEA | -- |
Pathways & Interactions for ANAPC11 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | CDK-mediated phosphorylation and removal of Cdc6 | ||
| 2 | APC-Cdc20 mediated degradation of Nek2A | ||
| 3 | Class I MHC mediated antigen processing and presentation | ||
| 4 | Cell Cycle, Mitotic |
.83
|
.60
|
| 5 | Cellular Senescence | ||
Pathways by source for ANAPC11 Gene
1 Sino Biological pathway for ANAPC11 Gene
1 Cell Signaling Technology pathway for ANAPC11 Gene
5 KEGG pathways for ANAPC11 Gene
7 GeneGo (Thomson Reuters) pathways for ANAPC11 Gene
6 Qiagen pathways for ANAPC11 Gene
UniProtKB/Swiss-Prot Q9NYG5-APC11_HUMAN
- Pathway: Protein modification; protein ubiquitination.
Interacting Proteins for ANAPC11 Gene
Selected Interacting proteins:
ENSP00000349957
Q9NYG5-APC11_HUMAN
for ANAPC11 Gene via
STRING
IID
UniProtKB
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000278 | mitotic cell cycle | TAS | 11739784 |
| GO:0007049 | cell cycle | IEA | -- |
| GO:0007067 | mitotic nuclear division | TAS | -- |
| GO:0016567 | protein ubiquitination | IEA,IDA | 11739784 |
| GO:0031145 | anaphase-promoting complex-dependent catabolic process | TAS | -- |
No data available for SIGNOR curated interactions for ANAPC11 Gene
Drugs & Compounds for ANAPC11 Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| TAME | Pharma | 0 |
(1) ApexBio Compounds for ANAPC11 Gene
| Compound | Action | Cas Number |
|---|---|---|
| TAME | 901-47-3 |
Drug Products
- ApexBio compounds for ANAPC11
Transcripts for ANAPC11 Gene
mRNA/cDNA for ANAPC11 Gene
- (14) REFSEQ mRNAs :
- (13) Additional mRNA sequences :
- (78) Selected AceView cDNA sequences:
- (23) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for ANAPC11 Gene
CRISPR Products
-
OriGene CRISPR knockouts for ANAPC11
-
Santa Cruz Biotechnology (SCBT) CRISPR for ANAPC11
- GenScript: Design CRISPR guide RNA sequences for ANAPC11
miRNA Products
- Search ViGene Biosciences for ANAPC11
Inhibitory RNA Products
- Origene RNAi, siRNA, and shRNA products in human, mouse, rat for ANAPC11
- Browse OriGene Inhibitory RNA Products For ANAPC11
-
ViGene Biosciences ready-to-package AAV shRNAs for ANAPC11 gene
Clone Products
-
OriGene ORF clones in human for ANAPC11
- RC200097
- RC200097L1
- RC200097L2
- RG200097
- RC223841
- RC223841L1
- RC223841L2
- RG223841
- RC224653
- RC224653L1
- RC224653L2
- RG224653
- RC215606
- RC215606L1
- RC215606L2
- RG215606
- RC222619
- RC222619L1
- RC222619L2
- RG222619
- RC224701
- RC224701L1
- RC224701L2
- RG224701
- RC235519
- RC235520
- RG224537
- RC224537L2
- RC224537L1
- RC224537
- RC235988
- RC235546
- RC235545
- RC235522
- RC235521
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for ANAPC11
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- Addgene plasmids for ANAPC11
- VectorBuilder custom plasmid, inducible vectors for ANAPC11
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for ANAPC11
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Flow Cytometry Products
| ExUns: | 1 | ^ | 2a | · | 2b | · | 2c | · | 2d | · | 2e | · | 2f | ^ | 3a | · | 3b | · | 3c | ^ | 4 | ^ | 5 | ^ | 6a | · | 6b | · | 6c | · | 6d | ^ | 7 | ^ | 8a | · | 8b | · | 8c | · | 8d | · | 8e | · | 8f |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||
| SP2: | - | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||
| SP3: | - | - | - | - | - | - | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||
| SP4: | - | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||
| SP5: | - | - | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||
| SP6: | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||
| SP7: | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||
| SP8: | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||
| SP9: | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||
| SP10: | - | - | - | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||
| SP11: | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||
| SP12: | - | - | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||
| SP13: | - | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||
| SP14: | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||
| SP15: | - | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||
| SP16: | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||
| SP17: | - | - | - |
Expression for ANAPC11 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
This gene is overexpressed in Bone (56.3) and Lung (12.7).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ANAPC11 Gene
NURSA nuclear receptor signaling pathways regulating expression of ANAPC11 Gene:
ANAPC11SOURCE GeneReport for Unigene cluster for ANAPC11 Gene:
Hs.534456mRNA Expression by UniProt/SwissProt for ANAPC11 Gene:
Q9NYG5-APC11_HUMAN
Tissue specificity:
Expressed at high levels in skeletal muscle and heart; in moderate levels in brain, kidney, and liver; and at low levels in colon, thymus, spleen, small intestine, placenta, lung and peripheral blood leukocyte.
Evidence on tissue expression from TISSUES for ANAPC11 Gene
- Nervous system(4.8)
- Blood(4.3)
- Skin(4.3)
- Lung(2.7)
- Muscle(2.2)
Primer Products
-
OriGene qPCR primer pairs for ANAPC11
-
OriGene qPCR primer pairs and template standards for ANAPC11
No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for ANAPC11 Gene
Orthologs for ANAPC11 Gene
This gene was present in the common ancestor of eukaryotes.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | ANAPC11 34 35 |
|
||
| dog (Canis familiaris) |
Mammalia | ANAPC11 34 35 |
|
||
| cow (Bos Taurus) |
Mammalia | ANAPC11 34 35 |
|
||
| mouse (Mus musculus) |
Mammalia | Anapc11 34 16 35 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Anapc11 34 |
|
||
| platypus (Ornithorhynchus anatinus) |
Mammalia | ANAPC11 35 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | anapc11 34 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | anapc11 34 35 |
|
||
| fruit fly (Drosophila melanogaster) |
Insecta | lmgA 34 |
|
||
| lmg 36 35 |
|
||||
| African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP008196 34 |
|
||
| worm (Caenorhabditis elegans) |
Secernentea | apc-11 35 |
|
OneToOne | |
| A. gosspyii yeast (Ashbya gossypii) |
Saccharomycetes | AGOS_AER016C 34 |
|
||
| baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | APC11 34 35 37 |
|
||
| K. lactis yeast (Kluyveromyces lactis) |
Saccharomycetes | KLLA0E17711g 34 |
|
||
| thale cress (Arabidopsis thaliana) |
eudicotyledons | APC11 34 |
|
||
| rice (Oryza sativa) |
Liliopsida | Os07g0411101 34 |
|
||
| bread mold (Neurospora crassa) |
Ascomycetes | NCU11300 34 |
|
||
| fission yeast (Schizosaccharomyces pombe) |
Schizosaccharomycetes | apc11 34 |
|
- Species where no ortholog for ANAPC11 was found in the sources mined by GeneCards:
-
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- chicken (Gallus gallus)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- lizard (Anolis carolinensis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- oppossum (Monodelphis domestica)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
Paralogs for ANAPC11 Gene
(12) SIMAP similar genes for ANAPC11 Gene using alignment to 4 proteins:
No data available for Paralogs for ANAPC11 Gene
Variants for ANAPC11 Gene
| SNP ID | Clin | Chr 17 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs1000030905 | -- | 81,895,528(+) | AGATG(A/G)AGGCC | intron-variant | |
| rs1000144064 | -- | 81,892,449(+) | GGGCG(A/G)CAGAG | intron-variant, upstream-variant-2KB | |
| rs1000204782 | -- | 81,898,743(+) | GAGGA(-/GTTTTAATTTAAAAAAAT)GCAAT | intron-variant | |
| rs1000262493 | -- | 81,893,374(+) | GGCGT(C/G)AGCCA | intron-variant, upstream-variant-2KB | |
| rs1000372449 | -- | 81,898,394(+) | CATCC(A/G)GAGGG | intron-variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv21913 | CNV | gain+loss | 19812545 |
| esv29964 | CNV | loss | 17803354 |
| esv33468 | CNV | loss | 17666407 |
| esv33475 | CNV | gain+loss | 17666407 |
| nsv1070854 | CNV | deletion | 25765185 |
| nsv1118775 | CNV | deletion | 24896259 |
| nsv428351 | CNV | gain | 18775914 |
| nsv470620 | CNV | loss | 18288195 |
| nsv833569 | CNV | loss | 17160897 |
| nsv952392 | CNV | deletion | 24416366 |
Residual Variation Intolerance Score:
64.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
0.71;
15.01% of all genes are more intolerant (likely to be disease-causing)
Relevant External Links for ANAPC11 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- ANAPC11
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ANAPC11 Gene
Disorders for ANAPC11 Gene
Relevant External Links for ANAPC11
- Atlas of Genetics and Cytogenetics in Oncology and Haematology:
- ANAPC11
No disorders were found for ANAPC11 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ANAPC11 Gene
Publications for ANAPC11 Gene
- Molecular cloning and characterization of a RING-H2 finger protein, ANAPC11, the human homolog of yeast Apc11p. (PMID: 11573242) Chan A.H. … Tsui S.K.W. (J. Cell. Biochem. 2001) 3 4 22 64
- The RING-H2 finger protein APC11 and the E2 enzyme UBC4 are sufficient to ubiquitinate substrates of the anaphase-promoting complex. (PMID: 10922056) Gmachl M. … Peters J.-M. (Proc. Natl. Acad. Sci. U.S.A. 2000) 2 3 4 64
- Molecular architecture and mechanism of the anaphase-promoting complex. (PMID: 25043029) Chang L. … Barford D. (Nature 2014) 3 4 64
- Mechanism of ubiquitin-chain formation by the human anaphase- promoting complex. (PMID: 18485873) Jin L. … Rape M. (Cell 2008) 3 4 64
- Localization of the coactivator Cdh1 and the cullin subunit Apc2 in a cryo-electron microscopy model of vertebrate APC/C. (PMID: 16364912) Dube P. … Stark H. (Mol. Cell 2005) 3 4 64
Products for ANAPC11 Gene
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Sources for ANAPC11 Gene
- (1) GeneCards
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- (38) FlyBase
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- (40) Pseudogene
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- (74) Cloud-Clone Corp.
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