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Aliases for ANAPC11 Gene

Aliases for ANAPC11 Gene

  • Anaphase Promoting Complex Subunit 11 2 3
  • APC11 3 4 6
  • Anaphase Promoting Complex Subunit 11 (Yeast APC11 Homolog) 2 3
  • Hepatocellular Carcinoma-Associated RING Finger Protein 3 4
  • Cyclosome Subunit 11 3 4
  • APC11 Anaphase Promoting Complex Subunit 11 Homolog 3
  • Anaphase-Promoting Complex Subunit 11 3
  • HSPC214 3
  • Apc11p 3

External Ids for ANAPC11 Gene

Previous GeneCards Identifiers for ANAPC11 Gene

  • GC17P079341
  • GC17P9I0152
  • GC17P080384
  • GC17P077442
  • GC17P079849
  • GC17P075220

Summaries for ANAPC11 Gene

GeneCards Summary for ANAPC11 Gene

ANAPC11 (Anaphase Promoting Complex Subunit 11) is a Protein Coding gene. Diseases associated with ANAPC11 include hepatocellular carcinoma. Among its related pathways are Class I MHC mediated antigen processing and presentation and PAK Pathway. GO annotations related to this gene include ubiquitin-protein transferase activity.

UniProtKB/Swiss-Prot for ANAPC11 Gene

  • Together with the cullin protein ANAPC2, constitutes the catalytic component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of Lys-11-linked polyubiquitin chains and, to a lower extent, the formation of Lys-48- and Lys-63-linked polyubiquitin chains. May recruit the E2 ubiquitin-conjugating enzymes to the complex.

Gene Wiki entry for ANAPC11 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ANAPC11 Gene

Genomics for ANAPC11 Gene

Regulatory Elements for ANAPC11 Gene

Transcription factor binding sites by QIAGEN in the ANAPC11 gene promoter:

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for ANAPC11 Gene

Start:
81,890,790 bp from pter
End:
81,900,991 bp from pter
Size:
10,202 bases
Orientation:
Plus strand

Genomic View for ANAPC11 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ANAPC11 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ANAPC11 Gene

Proteins for ANAPC11 Gene

  • Protein details for ANAPC11 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NYG5-APC11_HUMAN
    Recommended name:
    Anaphase-promoting complex subunit 11
    Protein Accession:
    Q9NYG5
    Secondary Accessions:
    • A8MTT2
    • B7ZW64
    • Q502X9
    • Q9BW64
    • Q9P0R2

    Protein attributes for ANAPC11 Gene

    Size:
    84 amino acids
    Molecular mass:
    9841 Da
    Quaternary structure:
    • The mammalian APC/C is composed of 14 distinct subunits that assemble into a complex of at least 19 chains with a combined molecular mass of around 1.2 MDa. Interacts with the cullin domain of ANAPC2. Interacts with UBE2D2.
    SequenceCaution:
    • Sequence=AAF36134.1; Type=Frameshift; Positions=67; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for ANAPC11 Gene

    Alternative splice isoforms for ANAPC11 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ANAPC11 Gene

Proteomics data for ANAPC11 Gene at MOPED

Post-translational modifications for ANAPC11 Gene

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for ANAPC11 (ANAPC11)

No data available for DME Specific Peptides for ANAPC11 Gene

Domains for ANAPC11 Gene

Gene Families for ANAPC11 Gene

HGNC:
  • ANAPC :Anaphase promoting complex subunits

Protein Domains for ANAPC11 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for ANAPC11 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9NYG5

UniProtKB/Swiss-Prot:

APC11_HUMAN :
  • Q9NYG5
Domain:
  • The RING-type zinc finger domain coordinates an additional third zinc ion
Family:
  • Belongs to the RING-box family.
Similarity:
  • Contains 1 RING-type zinc finger.
genes like me logo Genes that share domains with ANAPC11: view

Function for ANAPC11 Gene

Molecular function for ANAPC11 Gene

UniProtKB/Swiss-Prot Function: Together with the cullin protein ANAPC2, constitutes the catalytic component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of Lys-11-linked polyubiquitin chains and, to a lower extent, the formation of Lys-48- and Lys-63-linked polyubiquitin chains. May recruit the E2 ubiquitin-conjugating enzymes to the complex.

Gene Ontology (GO) - Molecular Function for ANAPC11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004842 contributes_to ubiquitin-protein transferase activity IDA 11739784
GO:0005515 protein binding --
GO:0008270 zinc ion binding IEA --
GO:0034450 ubiquitin-ubiquitin ligase activity IDA 10230407
GO:0061630 ubiquitin protein ligase activity IDA 10230407
genes like me logo Genes that share ontologies with ANAPC11: view

Phenotypes for ANAPC11 Gene

genes like me logo Genes that share phenotypes with ANAPC11: view

Animal Model Products

CRISPR Products

miRNA for ANAPC11 Gene

miRTarBase miRNAs that target ANAPC11

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for ANAPC11 Gene

Localization for ANAPC11 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ANAPC11 Gene

Cytoplasm. Nucleus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ANAPC11 Gene COMPARTMENTS Subcellular localization image for ANAPC11 gene
Compartment Confidence
nucleus 5
cytosol 4
extracellular 3

Gene Ontology (GO) - Cellular Components for ANAPC11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus --
GO:0005654 nucleoplasm TAS --
GO:0005680 anaphase-promoting complex IDA 11739784
GO:0005730 nucleolus IDA --
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with ANAPC11: view

Pathways for ANAPC11 Gene

SuperPathways for ANAPC11 Gene

genes like me logo Genes that share pathways with ANAPC11: view

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

UniProtKB/Swiss-Prot Q9NYG5-APC11_HUMAN

  • Pathway: Protein modification; protein ubiquitination

Gene Ontology (GO) - Biological Process for ANAPC11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000278 mitotic cell cycle TAS --
GO:0007067 mitotic nuclear division TAS 11739784
GO:0007094 mitotic spindle assembly checkpoint TAS --
GO:0016567 protein ubiquitination IDA 11739784
GO:0031145 anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process TAS --
genes like me logo Genes that share ontologies with ANAPC11: view

Transcripts for ANAPC11 Gene

Unigene Clusters for ANAPC11 Gene

Anaphase promoting complex subunit 11:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ANAPC11

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ANAPC11 Gene

ExUns: 1 ^ 2a · 2b · 2c · 2d · 2e · 2f ^ 3a · 3b · 3c ^ 4 ^ 5 ^ 6a · 6b · 6c · 6d ^ 7 ^ 8a · 8b · 8c · 8d · 8e · 8f
SP1: - - - - - - - -
SP2: - - - - - - - - -
SP3: - - - - - - - - - - - - - -
SP4: - - - - - - - - -
SP5: - - - - - - - - - -
SP6: - - - - - - - -
SP7: - - - - - - - -
SP8: - - - - -
SP9: - - - -
SP10: - - - - - - - - - - -
SP11: - - - - - -
SP12: - - - - - - - - - -
SP13: - - - - - - - - -
SP14: - - - - -
SP15: - - - - - - - - -
SP16: - - - - - -
SP17: - - -

Relevant External Links for ANAPC11 Gene

GeneLoc Exon Structure for
ANAPC11
ECgene alternative splicing isoforms for
ANAPC11

Expression for ANAPC11 Gene

mRNA expression in normal human tissues for ANAPC11 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for ANAPC11 Gene

SOURCE GeneReport for Unigene cluster for ANAPC11 Gene Hs.534456

mRNA Expression by UniProt/SwissProt for ANAPC11 Gene

Q9NYG5-APC11_HUMAN
Tissue specificity: Expressed at high levels in skeletal muscle and heart; in moderate levels in brain, kidney, and liver; and at low levels in colon, thymus, spleen, small intestine, placenta, lung and peripheral blood leukocyte.
genes like me logo Genes that share expressions with ANAPC11: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for ANAPC11 Gene

Orthologs for ANAPC11 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for ANAPC11 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ANAPC11 35
  • 99.21 (n)
  • 100 (a)
ANAPC11 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ANAPC11 35
  • 92.86 (n)
  • 97.62 (a)
ANAPC11 36
  • 50 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ANAPC11 35
  • 93.25 (n)
  • 98.81 (a)
ANAPC11 36
  • 51 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Anapc11 35
  • 89.29 (n)
  • 98.81 (a)
Anapc11 16
Anapc11 36
  • 51 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ANAPC11 36
  • 42 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Anapc11 35
  • 89.29 (n)
  • 98.81 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia anapc11 35
  • 82.14 (n)
  • 88.1 (a)
zebrafish
(Danio rerio)
Actinopterygii anapc11 35
  • 79.37 (n)
  • 91.67 (a)
anapc11 36
  • 44 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP008196 35
  • 72.69 (n)
  • 71.08 (a)
fruit fly
(Drosophila melanogaster)
Insecta lmg 36
  • 41 (a)
OneToOne
lmgA 35
  • 74.7 (n)
  • 72.29 (a)
lmg 37
  • 73 (a)
worm
(Caenorhabditis elegans)
Secernentea apc-11 36
  • 16 (a)
OneToOne
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AER016C 35
  • 59.92 (n)
  • 50 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes APC11 35
  • 54.76 (n)
  • 53.57 (a)
APC11 36
  • 19 (a)
OneToOne
APC11 38
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0E17711g 35
  • 49.21 (n)
  • 46.03 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons APC11 35
  • 61.79 (n)
  • 68.29 (a)
rice
(Oryza sativa)
Liliopsida Os07g0411101 35
  • 69.88 (n)
  • 69.88 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU11300 35
  • 64.91 (n)
  • 61.4 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes apc11 35
  • 54.58 (n)
  • 53.75 (a)
Species with no ortholog for ANAPC11:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ANAPC11 Gene

ENSEMBL:
Gene Tree for ANAPC11 (if available)
TreeFam:
Gene Tree for ANAPC11 (if available)

Paralogs for ANAPC11 Gene

Selected SIMAP similar genes for ANAPC11 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with ANAPC11: view

No data available for Paralogs for ANAPC11 Gene

Variants for ANAPC11 Gene

Sequence variations from dbSNP and Humsavar for ANAPC11 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
rs4433852 -- 81,898,248(+) TCTGG(C/T)TGCAT intron-variant
rs11431521 -- 81,897,006(+) TATTT(-/A)TTTAT intron-variant
rs11550400 -- 81,900,024(+) AGCAG(C/T)ACTGC reference, missense, synonymous-codon
rs11550402 -- 81,900,042(+) GCCGC(A/C)AGGAA missense, reference, synonymous-codon
rs11550404 -- 81,894,578(+) ATGCT(G/T)CCCTG reference, missense

Structural Variations from Database of Genomic Variants (DGV) for ANAPC11 Gene

Variant ID Type Subtype PubMed ID
nsv909052 CNV Loss 21882294
nsv428351 CNV Gain 18775914
dgv3330n71 CNV Loss 21882294
dgv3332n71 CNV Loss 21882294
nsv470620 CNV Loss 18288195
dgv3333n71 CNV Loss 21882294
nsv909134 CNV Loss 21882294
esv21913 CNV Gain+Loss 19812545
nsv909128 CNV Gain+Loss 21882294
nsv833569 CNV Loss 17160897
dgv3337n71 CNV Loss 21882294
dgv3338n71 CNV Loss 21882294
dgv3339n71 CNV Loss 21882294
nsv909151 CNV Gain+Loss 21882294
dgv3340n71 CNV Loss 21882294
dgv3341n71 CNV Loss 21882294
dgv3342n71 CNV Loss 21882294
esv29964 CNV Loss 17803354
esv33468 CNV Loss 17666407

Relevant External Links for ANAPC11 Gene

HapMap Linkage Disequilibrium report
ANAPC11

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ANAPC11 Gene

Disorders for ANAPC11 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (1) Diseases for ANAPC11 Gene including...

Search for ANAPC11 Gene in MalaCards »
genes like me logo Genes that share disorders with ANAPC11: view

No data available for UniProtKB/Swiss-Prot for ANAPC11 Gene

Publications for ANAPC11 Gene

  1. Molecular cloning and characterization of a RING-H2 finger protein, ANAPC11, the human homolog of yeast Apc11p. (PMID: 11573242) Chan A.H. … Tsui S.K.W. (J. Cell. Biochem. 2001) 3 4 23
  2. The RING-H2 finger protein APC11 and the E2 enzyme UBC4 are sufficient to ubiquitinate substrates of the anaphase-promoting complex. (PMID: 10922056) Gmachl M. … Peters J.-M. (Proc. Natl. Acad. Sci. U.S.A. 2000) 2 3 4
  3. Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. (PMID: 11042152) Zhang Q.-H. … Chen Z. (Genome Res. 2000) 3 4
  4. The RING-H2-finger protein APC11 as a target of hydrogen peroxide. (PMID: 15256223) Chang T.S. … Rhee S.G. (Free Radic. Biol. Med. 2004) 3 23
  5. APC2 cullin protein and APC11 RING protein comprise the minimal ubiquitin ligase module of the anaphase-promoting complex. (PMID: 11739784) Tang Z. … Yu H. (Mol. Biol. Cell 2001) 3 4

Products for ANAPC11 Gene

Sources for ANAPC11 Gene

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