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Aliases for ANAPC10 Gene

Aliases for ANAPC10 Gene

  • Anaphase Promoting Complex Subunit 10 2 3
  • APC10 3 4 6
  • Cyclosome Subunit 10 3 4
  • DOC1 3 6
  • Anaphase-Promoting Complex Subunit 10 3

External Ids for ANAPC10 Gene

Summaries for ANAPC10 Gene

Entrez Gene Summary for ANAPC10 Gene

  • ANAPC10 is a core subunit of the anaphase-promoting complex (APC), or cyclosome, a ubiquitin protein ligase that is essential for progression through the cell cycle. APC initiates sister chromatid separation by ubiquitinating the anaphase inhibitor securin (PTTG1; MIM 604147) and triggers exit from mitosis by ubiquitinating cyclin B (CCNB1; MIM 123836), the activating subunit of cyclin-dependent kinase-1 (CDK1; MIM 116940) (summary by Wendt et al., 2001 [PubMed 11524682]).[supplied by OMIM, Feb 2011]

GeneCards Summary for ANAPC10 Gene

ANAPC10 (Anaphase Promoting Complex Subunit 10) is a Protein Coding gene. Among its related pathways are Class I MHC mediated antigen processing and presentation and PAK Pathway. GO annotations related to this gene include ubiquitin-protein transferase activity.

UniProtKB/Swiss-Prot for ANAPC10 Gene

  • Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of Lys-11-linked polyubiquitin chains and, to a lower extent, the formation of Lys-48- and Lys-63-linked polyubiquitin chains.

Gene Wiki entry for ANAPC10 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ANAPC10 Gene

Genomics for ANAPC10 Gene

Genomic Location for ANAPC10 Gene

Start:
144,967,112 bp from pter
End:
145,098,541 bp from pter
Size:
131,430 bases
Orientation:
Minus strand

Genomic View for ANAPC10 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ANAPC10 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ANAPC10 Gene

Regulatory Elements for ANAPC10 Gene

Proteins for ANAPC10 Gene

  • Protein details for ANAPC10 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UM13-APC10_HUMAN
    Recommended name:
    Anaphase-promoting complex subunit 10
    Protein Accession:
    Q9UM13
    Secondary Accessions:
    • D3DNZ7
    • Q2V500
    • Q9UG51
    • Q9Y5R0

    Protein attributes for ANAPC10 Gene

    Size:
    185 amino acids
    Molecular mass:
    21252 Da
    Quaternary structure:
    • The mammalian APC/C is composed of 14 distinct subunits that assemble into a complex of at least 19 chains with a combined molecular mass of around 1.2 MDa. The C-terminus of APC10 binds to CDC27/APC3.

    Three dimensional structures from OCA and Proteopedia for ANAPC10 Gene

neXtProt entry for ANAPC10 Gene

Proteomics data for ANAPC10 Gene at MOPED

Post-translational modifications for ANAPC10 Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys6, Lys14, and Lys169

No data available for DME Specific Peptides for ANAPC10 Gene

Domains for ANAPC10 Gene

Gene Families for ANAPC10 Gene

HGNC:
  • ANAPC :Anaphase promoting complex subunits

Protein Domains for ANAPC10 Gene

Suggested Antigen Peptide Sequences for ANAPC10 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9UM13

UniProtKB/Swiss-Prot:

APC10_HUMAN
Domain:
  • Contains 1 DOC domain.:
    • Q9UM13
Family:
  • Belongs to the APC10 family.:
    • Q9UM13
genes like me logo Genes that share domains with ANAPC10: view

Function for ANAPC10 Gene

Molecular function for ANAPC10 Gene

UniProtKB/Swiss-Prot Function: Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of Lys-11-linked polyubiquitin chains and, to a lower extent, the formation of Lys-48- and Lys-63-linked polyubiquitin chains.

Phenotypes for ANAPC10 Gene

GenomeRNAi human phenotypes for ANAPC10:
genes like me logo Genes that share phenotypes with ANAPC10: view

miRNA for ANAPC10 Gene

miRTarBase miRNAs that target ANAPC10

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Animal Models , Transcription Factor Targeting and HOMER Transcription for ANAPC10 Gene

Localization for ANAPC10 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ANAPC10 Gene COMPARTMENTS Subcellular localization image for ANAPC10 gene
Compartment Confidence
nucleus 5
cytosol 4
golgi apparatus 1
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for ANAPC10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm TAS --
GO:0005680 anaphase-promoting complex IDA 10318877
GO:0005737 cytoplasm --
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with ANAPC10: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for ANAPC10 Gene

Pathways for ANAPC10 Gene

SuperPathways for ANAPC10 Gene

genes like me logo Genes that share pathways with ANAPC10: view

UniProtKB/Swiss-Prot Q9UM13-APC10_HUMAN

  • Pathway: Protein modification; protein ubiquitination

Gene Ontology (GO) - Biological Process for ANAPC10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000278 mitotic cell cycle TAS --
GO:0007067 mitotic nuclear division IEA --
GO:0007094 mitotic spindle assembly checkpoint TAS --
GO:0030071 regulation of mitotic metaphase/anaphase transition --
GO:0031145 anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process TAS --
genes like me logo Genes that share ontologies with ANAPC10: view

Transcripts for ANAPC10 Gene

Unigene Clusters for ANAPC10 Gene

Anaphase promoting complex subunit 10:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ANAPC10 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b · 7c
SP1: - - -
SP2: - -
SP3: -
SP4: -
SP5: - - - -

Relevant External Links for ANAPC10 Gene

GeneLoc Exon Structure for
ANAPC10
ECgene alternative splicing isoforms for
ANAPC10

Expression for ANAPC10 Gene

mRNA expression in normal human tissues for ANAPC10 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for ANAPC10 Gene

SOURCE GeneReport for Unigene cluster for ANAPC10 Gene Hs.480876

genes like me logo Genes that share expressions with ANAPC10: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for ANAPC10 Gene

Orthologs for ANAPC10 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for ANAPC10 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ANAPC10 35
  • 99.83 (n)
  • 100 (a)
ANAPC10 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ANAPC10 35
  • 96.22 (n)
  • 99.46 (a)
ANAPC10 36
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ANAPC10 35
  • 96.22 (n)
  • 100 (a)
ANAPC10 36
  • 100 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Anapc10 35
  • 92.61 (n)
  • 99.46 (a)
Anapc10 16
Anapc10 36
  • 99 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ANAPC10 36
  • 98 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ANAPC10 36
  • 98 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Anapc10 35
  • 91.35 (n)
  • 99.46 (a)
chicken
(Gallus gallus)
Aves ANAPC10 35
  • 88.65 (n)
  • 97.84 (a)
ANAPC10 36
  • 98 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ANAPC10 36
  • 97 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.10673 35
tropical clawed frog
(Silurana tropicalis)
Amphibia anapc10 35
  • 80.54 (n)
  • 94.59 (a)
zebrafish
(Danio rerio)
Actinopterygii anapc10 35
  • 74.41 (n)
  • 90.81 (a)
anapc10 36
  • 91 (a)
OneToOne
Dr.14526 35
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP011799 35
  • 57.25 (n)
  • 65.29 (a)
fruit fly
(Drosophila melanogaster)
Insecta Apc10 35
  • 57.3 (n)
  • 58.99 (a)
Apc10 36
  • 53 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea apc-10 36
  • 24 (a)
OneToMany
Y48G1C.12 35
  • 50.97 (n)
  • 48.55 (a)
Y48G1C.12 36
  • 35 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes DOC1 36
  • 21 (a)
OneToOne
DOC1 38
soybean
(Glycine max)
eudicotyledons Gma.10755 35
thale cress
(Arabidopsis thaliana)
eudicotyledons APC10 35
  • 57.72 (n)
  • 56.1 (a)
rice
(Oryza sativa)
Liliopsida Os.2307 35
Os05g0579800 35
  • 55.89 (n)
  • 56.1 (a)
wheat
(Triticum aestivum)
Liliopsida Ta.9190 35
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.7204 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 56 (a)
OneToOne
Species with no ortholog for ANAPC10:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for ANAPC10 Gene

ENSEMBL:
Gene Tree for ANAPC10 (if available)
TreeFam:
Gene Tree for ANAPC10 (if available)

Paralogs for ANAPC10 Gene

Selected SIMAP similar genes for ANAPC10 Gene using alignment to 5 proteins:

Pseudogenes.org Pseudogenes for ANAPC10 Gene

genes like me logo Genes that share paralogs with ANAPC10: view

No data available for Paralogs for ANAPC10 Gene

Variants for ANAPC10 Gene

Sequence variations from dbSNP and Humsavar for ANAPC10 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type MAF
rs167664 -- 145,043,598(+) TACTT(G/T)AGGTG intron-variant
rs172784 -- 145,034,031(+) acgaa(A/G)gatag intron-variant
rs178606 -- 145,038,903(+) TACTT(C/T)TGATG intron-variant
rs186487 -- 145,038,704(+) gtaat(C/T)tcagc intron-variant
rs188874 -- 145,034,003(+) ggttg(A/G)ggatt intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ANAPC10 Gene

Variant ID Type Subtype PubMed ID
esv22214 CNV Gain 19812545
dgv174n6 CNV Loss 16902084
esv2653755 CNV Deletion 19546169
esv2728486 CNV Deletion 23290073

Relevant External Links for ANAPC10 Gene

HapMap Linkage Disequilibrium report
ANAPC10

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ANAPC10 Gene

Disorders for ANAPC10 Gene

No disorders were found for ANAPC10 Gene.

No data available for UniProtKB/Swiss-Prot for ANAPC10 Gene

Publications for ANAPC10 Gene

  1. Characterization of the DOC1/APC10 subunit of the yeast and the human anaphase-promoting complex. (PMID: 10318877) Grossberger R. … Peters J.-M. (J. Biol. Chem. 1999) 2 3 4
  2. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PMID: 11230166) Wiemann S. … Poustka A. (Genome Res. 2001) 2 3 4
  3. TPR subunits of the anaphase-promoting complex mediate binding to the activator protein CDH1. (PMID: 12956947) Vodermaier H.C. … Peters J.M. (Curr. Biol. 2003) 3 23
  4. Identification of human APC10/Doc1 as a subunit of anaphase promoting complex. (PMID: 10498862) Kurasawa Y. … Todokoro K. (Oncogene 1999) 3 4
  5. Crystal structure of the APC10/DOC1 subunit of the human anaphase- promoting complex. (PMID: 11524682) Wendt K.S. … Sondermann P. (Nat. Struct. Biol. 2001) 3 4

Products for ANAPC10 Gene

Sources for ANAPC10 Gene

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