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ANAPC10 Gene

protein-coding   GIFtS: 62
GCID: GC04M145916

Anaphase Promoting Complex Subunit 10

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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This gene clusters with an RNA gene
Subcategory (RNA class): antisense

Quality score for the ORGUL clustered with this gene is 3

Aliases
Anaphase Promoting Complex Subunit 101 2
APC102 3 5
Cyclosome Subunit 102 3
DOC12 5
Anaphase-Promoting Complex Subunit 102

External Ids:    HGNC: 240771   Entrez Gene: 103932   Ensembl: ENSG000001641627   OMIM: 6137455   UniProtKB: Q9UM133   
ORGUL members:         

Export aliases for ANAPC10 gene to outside databases

Previous GC identifers: GC04M146490 GC04M146273 GC04M146135 GC04M141647


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for ANAPC10 Gene:
ANAPC10 is a core subunit of the anaphase-promoting complex (APC), or cyclosome, a ubiquitin protein ligase that
is essential for progression through the cell cycle. APC initiates sister chromatid separation by ubiquitinating
the anaphase inhibitor securin (PTTG1; MIM 604147) and triggers exit from mitosis by ubiquitinating cyclin B
(CCNB1; MIM 123836), the activating subunit of cyclin-dependent kinase-1 (CDK1; MIM 116940) (summary by Wendt et
al., 2001 (PubMed 11524682)).(supplied by OMIM, Feb 2011)

GeneCards Summary for ANAPC10 Gene:
ANAPC10 (anaphase promoting complex subunit 10) is a protein-coding gene. GO annotations related to this gene include ubiquitin-protein ligase activity.

UniProtKB/Swiss-Prot: APC10_HUMAN, Q9UM13
Function: Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin
ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by
mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of
'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked
polyubiquitin chains

Gene Wiki entry for ANAPC10 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000004.11  NT_016354.20  NC_018915.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the ANAPC10 gene promoter:
         Spz1   Pbx1a   AML1a   LCR-F1   E2F-1   E2F   Cart-1   MRF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidANAPC10 promoter sequence
   Search Chromatin IP Primers for ANAPC10

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ANAPC10


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4q31   Ensembl cytogenetic band:  4q31.21   HGNC cytogenetic band: 4q31

ANAPC10 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ANAPC10 gene location

GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04M145916:  view genomic region     (about GC identifiers)

Start:
145,888,264 bp from pter      End:
146,019,693 bp from pter
Size:
131,430 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: APC10_HUMAN, Q9UM13 (See protein sequence)
Recommended Name: Anaphase-promoting complex subunit 10  
Size: 185 amino acids; 21252 Da
Subunit: The APC/C is composed of at least 12 subunits. The C-terminus of APC10 binds to CDC27/APC3
1 PDB 3D structure from and Proteopedia for ANAPC10:
1JHJ (3D)    
Secondary accessions: D3DNZ7 Q2V500 Q9UG51 Q9Y5R0

Explore the universe of human proteins at neXtProt for ANAPC10: NX_Q9UM13

Explore proteomics data for ANAPC10 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys6, Lys14, Lys169
  • Modification sites at PhosphoSitePlus

  • See ANAPC10 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (8 alternative transcripts): 
    NP_001243635.1  NP_001243636.1  NP_001243637.1  NP_001243638.1  NP_001243639.1  NP_001243640.1  NP_001243641.1  NP_055700.2  

    ENSEMBL proteins: 
     ENSP00000423995   ENSP00000403891   ENSP00000310071   ENSP00000423043   ENSP00000421609  
     ENSP00000425459   ENSP00000423223   ENSP00000424463  
    Reactome Protein details: Q9UM13

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ANAPC: Anaphase promoting complex subunits

    3 InterPro protein domains:
     IPR004939 APC_su10/DOC_dom
     IPR008979 Galactose-bd-like
     IPR016901 APC_su10

    Graphical View of Domain Structure for InterPro Entry Q9UM13

    ProtoNet protein and cluster: Q9UM13

    UniProtKB/Swiss-Prot: APC10_HUMAN, Q9UM13
    Similarity: Belongs to the APC10 family
    Similarity: Contains 1 DOC domain


    Find genes that share domains with ANAPC10           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: APC10_HUMAN, Q9UM13
    Function: Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin
    ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by
    mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of
    'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked
    polyubiquitin chains

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004842ubiquitin-protein ligase activity TAS10318877
         
    Find genes that share ontologies with ANAPC10           About GenesLikeMe


    Phenotypes:
         2 GenomeRNAi human phenotypes for ANAPC10:
     Increased S DNA content  S arrest 

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for ANAPC10

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol4
    golgi apparatus1
    mitochondrion1
    peroxisome1

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005654nucleoplasm TAS--
    GO:0005680anaphase-promoting complex NAS10318877
    GO:0005737cytoplasm ----
    GO:0005829cytosol TAS--

    Find genes that share ontologies with ANAPC10           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for ANAPC10 About   (see all 17)  
    See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1Inactivation of APC/C via direct inhibition of the APC/C complex
    Inactivation of APC/C via direct inhibition of the APC/C complex0.64
    Mitotic Spindle Checkpoint0.62
    APC/C-Cdc20 mediated degradation of Cyclin B0.64
    Common schema of ubiquitination0.33
    Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components0.64
    2Class I MHC mediated antigen processing and presentation
    Class I MHC mediated antigen processing and presentation0.84
    Adaptive Immune System0.41
    Antigen processing- Ubiquitination and Proteasome degradation0.84
    Ubiquitin mediated proteolysis0.35
    3CDK-mediated phosphorylation and removal of Cdc6
    APC/C-mediated degradation of cell cycle proteins0.94
    Activation of APC/C and APC/C-Cdc20 mediated degradation of mitotic proteins0.92
    Regulation of mitotic cell cycle0.94
    Autodegradation of Cdh1 by Cdh1-APC/C0.91
    Regulation of APC/C activators between G1/S and early anaphase0.94
    Cell Cycle Checkpoints0.58
    APC/C-Cdc20 mediated degradation of Securin0.93
    Phosphorylation of the APC/C0.00
    4Mitotic Metaphase and Anaphase
    Mitotic Anaphase0.94
    Mitotic Metaphase and Anaphase0.93
    Separation of Sister Chromatids0.94
    5Cell Cycle, Mitotic
    Cell Cycle, Mitotic0.90
    M Phase0.62
    Cell Cycle0.90


    Find genes that share SuperPaths with ANAPC10           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for ANAPC10 (see all 6)
        Activation of PKA through GPCR
    Remodeling of Adherens Junctions
    cAMP Pathway
    CDC42 Pathway
    Mitotic Roles of Polo Like Kinases

    Selected GeneGo (Thomson Reuters) Pathways for ANAPC10 (see all 7)
        Cell cycle Role of APC in cell cycle regulation
    G-protein signaling G-Protein alpha-s signaling cascades
    Signal transduction PKA signaling
    Cell cycle Regulation of G1/S transition (part 1)
    Cell cycle Spindle assembly and chromosome separation

    1 BioSystems Pathway for ANAPC10
        TGF-beta Receptor Signaling Pathway


    Selected Reactome Pathways for ANAPC10 (see all 12)
        APC/C:Cdc20 mediated degradation of mitotic proteins
    Autodegradation of Cdh1 by Cdh1:APC/C
    Phosphorylation of the APC/C
    Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase
    APC/C:Cdc20 mediated degradation of Securin


    5 Kegg Pathways  (Kegg details for ANAPC10):
        Cell cycle
    Oocyte meiosis
    Ubiquitin mediated proteolysis
    Progesterone-mediated oocyte maturation
    HTLV-I infection

    UniProtKB/Swiss-Prot: APC10_HUMAN, Q9UM13
    Pathway: Protein modification; protein ubiquitination

        Pathway & Disease-focused RT2 Profiler PCR Array including ANAPC10: 

              Ubiquitin Ligases in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for ANAPC10

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for ANAPC10 (Q9UM133 ENSP000003100714) via UniProtKB, MINT, STRING, and/or I2D (see all 211)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CDC16Q130423, ENSP000003485544I2D: score=9 STRING: ENSP00000348554
    CDC23Q9UJX23, ENSP000003783504I2D: score=9 STRING: ENSP00000378350
    ACTBP607093, ENSP000003499604I2D: score=4 STRING: ENSP00000349960
    ATAD2Q6PL183, ENSP000002873944I2D: score=4 STRING: ENSP00000287394
    SMAD2Q157963, ENSP000002621604I2D: score=4 STRING: ENSP00000262160
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 12):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000086G2/M transition of mitotic cell cycle TAS10318877
    GO:0000090mitotic anaphase TAS10318877
    GO:0000278mitotic cell cycle TAS--
    GO:0006511ubiquitin-dependent protein catabolic process TAS10318877
    GO:0007067mitosis NAS10318877

    Find genes that share ontologies with ANAPC10           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Tocris compounds for ANAPC10 (APC10)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for ANAPC10 gene (8 alternative transcripts): 
    NM_001256706.1  NM_001256707.1  NM_001256708.1  NM_001256709.1  NM_001256710.1  NM_001256711.1  NM_001256712.1  NM_014885.4  

    Unigene Cluster for ANAPC10:

    Anaphase promoting complex subunit 10
    Hs.480876  [show with all ESTs]
    Unigene Representative Sequence: NM_001256708
    16 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000506851 ENST00000502651 ENST00000507656(uc003ijv.4) ENST00000451299(uc003iju.4)
    ENST00000309439(uc003ijw.4) ENST00000510270 ENST00000511466 ENST00000514390
    ENST00000513054 ENST00000502562 ENST00000512680 ENST00000508087 ENST00000504721
    ENST00000514704 ENST00000507134 ENST00000502847
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    Additional mRNA sequence: 

    AB012109.1 AF132794.1 AL080090.1 BC005217.1 NR_046345.1 

    19 DOTS entries:

    DT.105952  DT.92437684  DT.40120878  DT.95166329  DT.92437688  DT.100740001  DT.100697667  DT.121275115 
    DT.305310  DT.92437705  DT.95166327  DT.95166328  DT.121275102  DT.92437704  DT.99944981  DT.448327 
    DT.92437698  DT.95306494  DT.99933504 

    Selected AceView cDNA sequences (see all 95):

    CA942372 AI082438 AA262889 AW025455 BQ010833 AV714084 AI401407 BX111404 
    AA947769 AA234328 BG546805 BU175327 BI668952 AI719628 AI829179 BI488888 
    AI024091 BX475971 AI358235 BM921310 AW471337 CD701794 BU951990 CB243346 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for ANAPC10    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b · 7c
    SP1:                    -                       -     -                     
    SP2:                                            -     -                     
    SP3:                                            -                           
    SP4:                    -                                                   
    SP5:                          -           -     -     -                     


    ECgene alternative splicing isoforms for ANAPC10

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ANAPC10 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TAATAAAGCT
    ANAPC10 Expression
    About this image

    ANAPC10 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ANAPC10 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.480876
        Pathway & Disease-focused RT2 Profiler PCR Array including ANAPC10: 
              Ubiquitin Ligases in human mouse rat

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for ANAPC10 gene from Selected species (see all 22)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Anapc101 , 5 anaphase promoting complex subunit 101, 5 92.61(n)1
    99.46(a)1
      8 (37.79 cM)5
    689991  NM_026904.21  NP_081180.11 
     797118205 
    chicken
    (Gallus gallus)
    Aves ANAPC101 anaphase promoting complex subunit 10 88.65(n)
    97.84(a)
      422461  NM_001008467.1  NP_001008467.1 
    lizard
    (Anolis carolinensis)
    Reptilia ANAPC106
    anaphase promoting complex subunit 10
    97(a)
    1 ↔ 1
    5(117972603-118002428)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.106732 Xenopus laevis transcribed sequence with strong similarity more 80.7(n)    CA971730.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.145262 Transcribed sequence with moderate similarity to protein more 76.03(n)    BI673624.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Apc101 Anaphase promoting complex subunit 10 57.3(n)
    58.99(a)
      36975  NM_137379.4  NP_611223.4 
    worm
    (Caenorhabditis elegans)
    Secernentea Y48G1C.121 Y48G1C.12 50.97(n)
    48.55(a)
      3565580  NM_001026606.1  NP_001021777.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes DOC1(YGL240W)4 Processivity factor required for the ubiquitination more   --   7(48613-49365) 852611  NP_011274.2 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons APC101 APC10 57.72(n)
    56.1(a)
      816345  NM_127387.3  NP_565433.1 
    rice
    (Oryza sativa)
    Liliopsida Os.23072 Oryza sativa (japonica cultivar-group) cDNA clone0 more 73.6(n)    AK064624.1 


    ENSEMBL Gene Tree for ANAPC10 (if available)
    TreeFam Gene Tree for ANAPC10 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for ANAPC10 gene
    1 SIMAP similar gene for ANAPC10 using alignment to 5 protein entries:     APC10_HUMAN (see all proteins):
    APC10

    Find genes that share paralogs with ANAPC10           About GenesLikeMe


    2 Pseudogenes.org Pseudogenes for ANAPC10
    PGOHUM00000239894 PGOHUM00000244720


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ANAPC10 (see all 1819)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 4 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs170198151,2
    C,F--145915285(+) AAGTAT/CAATGT 9 -- ds50019Minor allele frequency- C:0.02NA NS WA 440
    rs355513761,2
    C,F--145915359(-) AAAGCA/GTGATA 9 -- ds50015Minor allele frequency- G:0.01NS 182
    rs345855521,2
    C--145915499(-) TATTCT/CGGCAG 9 -- ds50017Minor allele frequency- C:0.01NS NA 184
    rs1874305071,2
    --145915549(+) ATACTG/TTAGTG 9 -- ds50010--------
    rs340740441,2
    C,F--145915602(-) ATTCAC/TTCTTG 9 -- ds50016Minor allele frequency- T:0.01NS NA 308
    rs170198191,2
    C,F--145915619(+) AAATTC/TTGTGG 9 -- ds50014Minor allele frequency- T:0.01NA CSA 144
    rs10172781,2
    C,F--145915713(-) ATGTGT/GTTTTT 9 -- ds500114Minor allele frequency- G:0.03MN NS NA WA CSA EA 739
    rs1508882461,2
    --145915880(+) ACTGCC/TAGATT 9 -- ut31 nc-transcript-variant0--------
    rs1927401211,2
    --145915958(+) GGTGAA/GTATGA 9 -- ut31 nc-transcript-variant0--------
    rs361110341,2
    C,F--145916007(-) AGGTTG/CTCTGA 9 -- ut31 nc-transcript-variant5Minor allele frequency- C:0.01NS 186

    HapMap Linkage Disequilibrium report for ANAPC10 (145888264 - 146019693 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for ANAPC10:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2728486CNV Deletion23290073
    esv2653755CNV Deletion19546169
    dgv174n6CNV Loss16902084
    esv22214CNV Gain19812545

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing ANAPC10
    DNA2.0 Custom Variant and Variant Library Synthesis for ANAPC10

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 613745    OMIM disorders: --


    Find genes that share disorders with ANAPC10           About GenesLikeMe


    Export disorders for ANAPC10 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ANAPC10 gene, integrated from 10 sources (see all 43):
    (articles sorted by number of sources associating them with ANAPC10)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PubMed id 11230166)1, 2, 3 Wiemann S.... Poustka A. (Genome Res. 2001)
    2. Characterization of the DOC1/APC10 subunit of the yeast and the human anaphase-promoting complex. (PubMed id 10318877)1, 2, 3 Grossberger R.... Peters J.-M. (J. Biol. Chem. 1999)
    3. Mechanism of ubiquitin-chain formation by the human anaphase- promoting complex. (PubMed id 18485873)1, 2 Jin L.... Rape M. (Cell 2008)
    4. Localization of the coactivator Cdh1 and the cullin subunit Apc2 in a cryo-electron microscopy model of vertebrate APC/C. (PubMed id 16364912)1, 2 Dube P.... Stark H. (Mol. Cell 2005)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    6. Crystal structure of the APC10/DOC1 subunit of the human anaphase- promoting complex. (PubMed id 11524682)1, 2 Wendt K.S.... Sondermann P. (Nat. Struct. Biol. 2001)
    7. Identification of human APC10/Doc1 as a subunit of anaphase promoting complex. (PubMed id 10498862)1, 2 Kurasawa Y. and Todokoro K. (Oncogene 1999)
    8. TPR subunits of the anaphase-promoting complex mediate binding to the activator protein CDH1. (PubMed id 12956947)1, 9 Vodermaier H.C....Peters J.M. (Curr. Biol. 2003)
    9. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (Cell 2012)
    10. Charting the landscape of tandem BRCT domain-mediated protein interactions. (PubMed id 22990118)1 Woods N.T....Monteiro A.N. (Sci Signal 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 10393 HGNC: 24077 AceView: ANAPC10 Ensembl:ENSG00000164162 euGenes: HUgn10393
    ECgene: ANAPC10 Kegg: 10393 H-InvDB: ANAPC10

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for ANAPC10 Pharmacogenomics, SNPs, Pathways
    NIEHS-SNPshttp://egp.gs.washington.edu/data/anapc10/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for ANAPC10 gene:
    Search GeneIP for patents involving ANAPC10

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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