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Aliases for ANAPC1 Gene

Aliases for ANAPC1 Gene

  • Anaphase Promoting Complex Subunit 1 2 3 5
  • Testis-Specific Gene 24 Protein 3 4
  • Mitotic Checkpoint Regulator 3 4
  • Cyclosome Subunit 1 3 4
  • TSG24 3 4
  • APC1 3 4
  • Anaphase-Promoting Complex 1 (Meiotic Checkpoint Regulator) 3
  • MCPR 3

External Ids for ANAPC1 Gene

Previous GeneCards Identifiers for ANAPC1 Gene

  • GC02M110445
  • GC02M112430
  • GC02M112621
  • GC02M112242
  • GC02M087019
  • GC02M112523

Summaries for ANAPC1 Gene

Entrez Gene Summary for ANAPC1 Gene

  • This gene encodes a subunit of the anaphase-promoting complex. This complex is an E3 ubiquitin ligase that regulates progression through the metaphase to anaphase portion of the cell cycle by ubiquitinating proteins which targets them for degradation. [provided by RefSeq, Dec 2011]

GeneCards Summary for ANAPC1 Gene

ANAPC1 (Anaphase Promoting Complex Subunit 1) is a Protein Coding gene. Among its related pathways are Immune System and Cellular Senescence.

UniProtKB/Swiss-Prot for ANAPC1 Gene

  • Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of Lys-11-linked polyubiquitin chains and, to a lower extent, the formation of Lys-48- and Lys-63-linked polyubiquitin chains.

Gene Wiki entry for ANAPC1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ANAPC1 Gene

Genomics for ANAPC1 Gene

Regulatory Elements for ANAPC1 Gene

Promoters for ANAPC1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around ANAPC1 on UCSC Golden Path with GeneCards custom track

Genomic Location for ANAPC1 Gene

Chromosome:
2
Start:
111,766,271 bp from pter
End:
111,884,690 bp from pter
Size:
118,420 bases
Orientation:
Minus strand

Genomic View for ANAPC1 Gene

Genes around ANAPC1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ANAPC1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ANAPC1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ANAPC1 Gene

Proteins for ANAPC1 Gene

  • Protein details for ANAPC1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H1A4-APC1_HUMAN
    Recommended name:
    Anaphase-promoting complex subunit 1
    Protein Accession:
    Q9H1A4
    Secondary Accessions:
    • Q2M3H8
    • Q9BSE6
    • Q9H8D0

    Protein attributes for ANAPC1 Gene

    Size:
    1944 amino acids
    Molecular mass:
    216500 Da
    Quaternary structure:
    • The mammalian APC/C is composed of 14 distinct subunits that assemble into a complex of at least 19 chains with a combined molecular mass of around 1.2 MDa.

    Three dimensional structures from OCA and Proteopedia for ANAPC1 Gene

neXtProt entry for ANAPC1 Gene

Proteomics data for ANAPC1 Gene at MOPED

Post-translational modifications for ANAPC1 Gene

  • Phosphorylated. Phosphorylation on Ser-355 occurs specifically during mitosis.
  • Ubiquitination at Lys 310, Lys 695, Lys 905, Lys 985, and Lys 1066
  • Modification sites at PhosphoSitePlus

Other Protein References for ANAPC1 Gene

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for ANAPC1 (APC1)

No data available for DME Specific Peptides for ANAPC1 Gene

Domains & Families for ANAPC1 Gene

Gene Families for ANAPC1 Gene

Protein Domains for ANAPC1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for ANAPC1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9H1A4

UniProtKB/Swiss-Prot:

APC1_HUMAN :
  • Belongs to the APC1 family.
  • Contains 4 PC repeats.
Family:
  • Belongs to the APC1 family.
Similarity:
  • Contains 4 PC repeats.
genes like me logo Genes that share domains with ANAPC1: view

Function for ANAPC1 Gene

Molecular function for ANAPC1 Gene

UniProtKB/Swiss-Prot Function:
Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of Lys-11-linked polyubiquitin chains and, to a lower extent, the formation of Lys-48- and Lys-63-linked polyubiquitin chains.
genes like me logo Genes that share phenotypes with ANAPC1: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ANAPC1 Gene

Localization for ANAPC1 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ANAPC1 Gene COMPARTMENTS Subcellular localization image for ANAPC1 gene
Compartment Confidence
nucleus 5
cytosol 4
plasma membrane 3

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for ANAPC1 Gene

Pathways & Interactions for ANAPC1 Gene

SuperPathways for ANAPC1 Gene

Superpath Contained pathways
1 CDK-mediated phosphorylation and removal of Cdc6
2 APC-Cdc20 mediated degradation of Nek2A
3 Cellular Senescence
4 Cell Cycle, Mitotic
.61
5 Mitotic Metaphase and Anaphase
genes like me logo Genes that share pathways with ANAPC1: view

UniProtKB/Swiss-Prot Q9H1A4-APC1_HUMAN

  • Pathway: Protein modification; protein ubiquitination.

SIGNOR curated interactions for ANAPC1 Gene

Is activated by:

Gene Ontology (GO) - Biological Process for ANAPC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007067 mitotic nuclear division IEA --
GO:0031145 anaphase-promoting complex-dependent catabolic process TAS --
GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process TAS --
GO:0051301 cell division IEA --
GO:0051436 negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle TAS --
genes like me logo Genes that share ontologies with ANAPC1: view

Drugs & Compounds for ANAPC1 Gene

No Compound Related Data Available

Transcripts for ANAPC1 Gene

Unigene Clusters for ANAPC1 Gene

Anaphase promoting complex subunit 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ANAPC1 Gene

No ASD Table

Relevant External Links for ANAPC1 Gene

GeneLoc Exon Structure for
ANAPC1
ECgene alternative splicing isoforms for
ANAPC1

Expression for ANAPC1 Gene

mRNA expression in normal human tissues for ANAPC1 Gene

Protein differential expression in normal tissues from HIPED for ANAPC1 Gene

This gene is overexpressed in Breast (24.6), Lung (15.2), and Cerebrospinal fluid (6.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MOPED, and MaxQB for ANAPC1 Gene



SOURCE GeneReport for Unigene cluster for ANAPC1 Gene Hs.436527

genes like me logo Genes that share expression patterns with ANAPC1: view

Protein tissue co-expression partners for ANAPC1 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for ANAPC1 Gene

Orthologs for ANAPC1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for ANAPC1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ANAPC1 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ANAPC1 36
  • 95 (a)
OneToOne
ANAPC1 35
  • 90.05 (n)
  • 95.57 (a)
dog
(Canis familiaris)
Mammalia ANAPC1 35
  • 93.4 (n)
  • 97.43 (a)
ANAPC1 36
  • 96 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Anapc1 16
Anapc1 36
  • 92 (a)
OneToOne
Anapc1 35
  • 87.93 (n)
  • 92.39 (a)
oppossum
(Monodelphis domestica)
Mammalia ANAPC1 36
  • 90 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 87 (a)
OneToMany
-- 36
  • 95 (a)
OneToMany
-- 36
  • 80 (a)
OneToMany
-- 36
  • 83 (a)
OneToMany
-- 36
  • 77 (a)
OneToMany
-- 36
  • 84 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Anapc1 35
  • 87.96 (n)
  • 92.95 (a)
chicken
(Gallus gallus)
Aves ANAPC1 36
  • 81 (a)
OneToOne
ANAPC1 35
  • 76.53 (n)
  • 81.9 (a)
lizard
(Anolis carolinensis)
Reptilia ANAPC1 36
  • 84 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia anapc1 35
  • 73.59 (n)
  • 80.81 (a)
Str.16338 35
zebrafish
(Danio rerio)
Actinopterygii anapc1 36
  • 67 (a)
OneToOne
anapc1 35
  • 65.73 (n)
  • 68.41 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP000374 35
  • 43.77 (n)
  • 36 (a)
fruit fly
(Drosophila melanogaster)
Insecta shtd 35
  • 46.97 (n)
  • 39.07 (a)
shtd 36
  • 29 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea mat-2 36
  • 19 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes APC1 36
  • 19 (a)
OneToOne
APC1 38
thale cress
(Arabidopsis thaliana)
eudicotyledons EMB2771 35
  • 45.78 (n)
  • 35.82 (a)
rice
(Oryza sativa)
Liliopsida Os05g0354300 35
  • 49.44 (n)
  • 39.64 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 32 (a)
OneToOne
Species with no ortholog for ANAPC1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ANAPC1 Gene

ENSEMBL:
Gene Tree for ANAPC1 (if available)
TreeFam:
Gene Tree for ANAPC1 (if available)

Paralogs for ANAPC1 Gene

genes like me logo Genes that share paralogs with ANAPC1: view

No data available for Paralogs for ANAPC1 Gene

Variants for ANAPC1 Gene

Sequence variations from dbSNP and Humsavar for ANAPC1 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs939791 -- 111,774,145(+) gctat(C/T)gcaga intron-variant
rs1357214 -- 111,788,404(+) TATAC(A/C/G/T)CCAGT intron-variant
rs1044864 -- 111,769,289(-) GTGAC(C/T)GTGTC utr-variant-3-prime
rs1273185 -- 111,847,030(+) GCTAA(A/G)AACTT intron-variant
rs1516637 -- 111,876,762(-) CTACC(A/G)TTAAC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ANAPC1 Gene

Variant ID Type Subtype PubMed ID
nsv521956 CNV Loss 19592680
nsv428402 CNV Loss 18775914
dgv1236e1 CNV Complex 17122850
dgv1237e1 CNV Complex 17122850
dgv1238e1 CNV Complex 17122850
esv27292 CNV Gain+Loss 19812545
dgv4277n71 CNV Gain 21882294
nsv10127 CNV Gain 18304495
nsv874860 CNV Gain 21882294
nsv834333 CNV Gain 17160897
nsv874862 CNV Loss 21882294
nsv215083 CNV Loss 16902084
nsv514974 CNV Complex 21397061
nsv874863 CNV Loss 21882294
esv26491 CNV Gain 19812545
dgv4278n71 CNV Gain 21882294

Variation tolerance for ANAPC1 Gene

Residual Variation Intolerance Score: 77.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.05; 50.48% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ANAPC1 Gene

HapMap Linkage Disequilibrium report
ANAPC1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ANAPC1 Gene

Disorders for ANAPC1 Gene

Relevant External Links for ANAPC1

Human Genome Epidemiology (HuGE) Navigator
ANAPC1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ANAPC1

No disorders were found for ANAPC1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ANAPC1 Gene

Publications for ANAPC1 Gene

  1. Characterisation of the human APC1, the largest subunit of the anaphase-promoting complex. (PMID: 11179667) Joergensen P.M. … Hoeoeg C. (Gene 2001) 2 3 4 23 67
  2. Integrative analysis of kinase networks in TRAIL-induced apoptosis provides a source of potential targets for combination therapy. (PMID: 25852190) So J. … Colwill K. (Sci Signal 2015) 3
  3. Temporal proteomics of NGF-TrkA signaling identifies an inhibitory role for the E3 ligase Cbl-b in neuroblastoma cell differentiation. (PMID: 25921289) Emdal K.B. … Olsen J.V. (Sci Signal 2015) 3
  4. Atomic structure of the APC/C and its mechanism of protein ubiquitination. (PMID: 26083744) Chang L. … Barford D. (Nature 2015) 3
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3

Products for ANAPC1 Gene

Sources for ANAPC1 Gene

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