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ANAPC1 Gene

protein-coding   GIFtS: 59
GCID: GC02M112523

Anaphase Promoting Complex Subunit 1

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Anaphase Promoting Complex Subunit 11 2     TSG242 3
APC12 3 5     MCPR2
Cyclosome Subunit 12 3     Anaphase-Promoting Complex 1 (Meiotic Checkpoint Regulator)2
Mitotic Checkpoint Regulator2 3     Anaphase-Promoting Complex Subunit 12
Testis-Specific Gene 24 Protein2 3     ANAP15

External Ids:    HGNC: 199881   Entrez Gene: 646822   Ensembl: ENSG000001531077   OMIM: 6084735   UniProtKB: Q9H1A43   

Export aliases for ANAPC1 gene to outside databases

Previous GC identifers: GC02M110445 GC02M112430 GC02M112621 GC02M112242 GC02M087019


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for ANAPC1 Gene:
This gene encodes a subunit of the anaphase-promoting complex. This complex is an E3 ubiquitin ligase that
regulates progression through the metaphase to anaphase portion of the cell cycle by ubiquitinating proteins
which targets them for degradation. (provided by RefSeq, Dec 2011)

GeneCards Summary for ANAPC1 Gene:
ANAPC1 (anaphase promoting complex subunit 1) is a protein-coding gene. Diseases associated with ANAPC1 include nicotine dependence, and cytomegalovirus infection.

UniProtKB/Swiss-Prot: APC1_HUMAN, Q9H1A4
Function: Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin
ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by
mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of
'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked
polyubiquitin chains

Gene Wiki entry for ANAPC1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000002.12  NT_005403.18  NC_018913.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the ANAPC1 gene promoter:
         GR   Nkx3-1   Nkx3-1 v4   Nkx3-1 v1   AREB6   Nkx3-1 v2   Nkx3-1 v3   GR-alpha   ZIC2/Zic2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): ANAPC1 promoter sequence
   Search Chromatin IP Primers for ANAPC1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ANAPC1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q12.1   Ensembl cytogenetic band:  2q13   HGNC cytogenetic band: 2q12.1

ANAPC1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ANAPC1 gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02M112523:  view genomic region     (about GC identifiers)

Start:
112,523,848 bp from pter      End:
112,642,267 bp from pter
Size:
118,420 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: APC1_HUMAN, Q9H1A4 (See protein sequence)
Recommended Name: Anaphase-promoting complex subunit 1  
Size: 1944 amino acids; 216500 Da
Subunit: The APC/C is composed of at least 12 subunits
Secondary accessions: Q2M3H8 Q9BSE6 Q9H8D0

Explore the universe of human proteins at neXtProt for ANAPC1: NX_Q9H1A4

Explore proteomics data for ANAPC1 at MOPED

Post-translational modifications: 

  • Phosphorylated. Phosphorylation on Ser-355 occurs specifically during mitosis1
  • Ubiquitination2 at Lys310, Lys379, Lys695, Lys905, Lys985, Lys1066
  • Modification sites at PhosphoSitePlus

  • See ANAPC1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_073153.1  
    ENSEMBL proteins: 
     ENSP00000396695   ENSP00000339109   ENSP00000405375  
    Reactome Protein details: Q9H1A4

    ANAPC1 Human Recombinant Protein Products:

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    Cloud-Clone Corp. Proteins for ANAPC1

    ANAPC1 Antibody Products:

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    ANAPC1 Assay Products:

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    Cloud-Clone Corp. ELISAs for ANAPC1
    Cloud-Clone Corp. CLIAs for ANAPC1


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ANAPC: Anaphase promoting complex subunits

    1 InterPro protein domain:
     IPR024990 Apc1

    Graphical View of Domain Structure for InterPro Entry Q9H1A4

    ProtoNet protein and cluster: Q9H1A4

    UniProtKB/Swiss-Prot: APC1_HUMAN, Q9H1A4
    Similarity: Belongs to the APC1 family
    Similarity: Contains 4 PC repeats


    ANAPC1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: APC1_HUMAN, Q9H1A4
    Function: Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin
    ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by
    mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of
    'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked
    polyubiquitin chains

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
         
    ANAPC1 for ontologies           About GeneDecksing


    Phenotypes:
         5 GenomeRNAi human phenotypes for ANAPC1:
     Cell cycle / mitosis defect  Increased S DNA content  Increased cell death HMECs cel  Increased number of mitotic ce 
     Synthetic lethal with Ras 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for ANAPC1
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       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for ANAPC1

    miRNA
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    miRTarBase miRNAs that target ANAPC1:
    hsa-mir-26b-5p (MIRT029746), hsa-mir-484 (MIRT042122), hsa-let-7b-5p (MIRT001653), hsa-mir-193b-3p (MIRT041534), hsa-mir-100-5p (MIRT048538), hsa-mir-744-5p (MIRT037555)

    Block miRNA regulation of human, mouse, rat ANAPC1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate ANAPC1 (see all 15):
    hsa-miR-548j hsa-miR-548w hsa-miR-495 hsa-miR-559 hsa-miR-520d-5p hsa-miR-548i hsa-miR-548h hsa-miR-548c-5p
    SwitchGear 3'UTR luciferase reporter plasmidANAPC1 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for ANAPC1
    Predesigned siRNA for gene silencing in human, mouse, rat ANAPC1

    Gene Editing
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    GenScript: all cDNA clones in your preferred vector: ANAPC1 (NM_014885)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ANAPC1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ANAPC1

    Cell Line
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ANAPC1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol4
    plasma membrane3

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus ----
    GO:0005654nucleoplasm TAS--
    GO:0005680anaphase-promoting complex IDA16364912
    GO:0005829cytosol TAS--

    ANAPC1 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for ANAPC1 About   (see all 22)  
    See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1Inactivation of APC/C via direct inhibition of the APC/C complex
    Inactivation of APC/C via direct inhibition of the APC/C complex0.64
    Mitotic Spindle Checkpoint0.62
    APC/C-Cdc20 mediated degradation of Cyclin B0.64
    Common schema of ubiquitination0.33
    Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components0.64
    2Class I MHC mediated antigen processing and presentation
    Class I MHC mediated antigen processing and presentation0.84
    Adaptive Immune System0.41
    Antigen processing- Ubiquitination and Proteasome degradation0.84
    Ubiquitin mediated proteolysis0.35
    3CDK-mediated phosphorylation and removal of Cdc6
    APC/C-mediated degradation of cell cycle proteins0.94
    Activation of APC/C and APC/C-Cdc20 mediated degradation of mitotic proteins0.92
    Regulation of mitotic cell cycle0.94
    Autodegradation of Cdh1 by Cdh1-APC/C0.91
    Regulation of APC/C activators between G1/S and early anaphase0.94
    Cell Cycle Checkpoints0.58
    APC/C-Cdc20 mediated degradation of Securin0.93
    Phosphorylation of the APC/C0.00
    4Mitotic Metaphase and Anaphase
    Mitotic Anaphase0.94
    Mitotic Metaphase and Anaphase0.93
    Separation of Sister Chromatids0.94
    5Cell Cycle, Mitotic
    Cell Cycle, Mitotic0.90
    M Phase0.62
    Cell Cycle0.90

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for ANAPC1 (see all 6)
        Activation of PKA through GPCR
    Remodeling of Adherens Junctions
    cAMP Pathway
    CDC42 Pathway
    Mitotic Roles of Polo Like Kinases

    Selected GeneGo (Thomson Reuters) Pathways for ANAPC1 (see all 7)
        Cell cycle Role of APC in cell cycle regulation
    G-protein signaling G-Protein alpha-s signaling cascades
    Signal transduction PKA signaling
    Cell cycle Regulation of G1/S transition (part 1)
    Cell cycle Spindle assembly and chromosome separation

    1 BioSystems Pathway for ANAPC1
        TGF-beta Receptor Signaling Pathway

    Selected Reactome Pathways for ANAPC1 (see all 12)
        APC/C:Cdc20 mediated degradation of mitotic proteins
    Autodegradation of Cdh1 by Cdh1:APC/C
    Phosphorylation of the APC/C
    Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase
    APC/C:Cdc20 mediated degradation of Securin


    5 Kegg Pathways  (Kegg details for ANAPC1):
        Cell cycle
    Oocyte meiosis
    Ubiquitin mediated proteolysis
    Progesterone-mediated oocyte maturation
    HTLV-I infection

    UniProtKB/Swiss-Prot: APC1_HUMAN, Q9H1A4
    Pathway: Protein modification; protein ubiquitination


    ANAPC1 for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Array including ANAPC1: 

              Adherens Junctions in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for ANAPC1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for ANAPC1 (Q9H1A42, 3 ENSP000003391094) via UniProtKB, MINT, STRING, and/or I2D (see all 889)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ANAPC7Q9UJX32, 3, ENSP000003943944MINT-8412994 MINT-7947479 I2D: score=2 STRING: ENSP00000394394
    CDC16Q130422, 3, ENSP000003485544MINT-7945693 MINT-7947479 I2D: score=2 STRING: ENSP00000348554
    CDC23Q9UJX22, 3, ENSP000003783504MINT-7945693 MINT-7947479 I2D: score=2 STRING: ENSP00000378350
    BUB3O436842, 3, ENSP000003578584MINT-7945693 MINT-7947479 I2D: score=1 STRING: ENSP00000357858
    ANAPC2Q9UJX62, 3, ENSP000003140044MINT-7947479 I2D: score=2 STRING: ENSP00000314004
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000278mitotic cell cycle TAS--
    GO:0007067mitosis IEA--
    GO:0007094mitotic spindle assembly checkpoint TAS--
    GO:0031145anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process TAS--
    GO:0051436negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle TAS--

    ANAPC1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ANAPC1 (APC1)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for ANAPC1 gene: 
    NM_022662.3  

    Unigene Cluster for ANAPC1:

    Anaphase promoting complex subunit 1
    Hs.436527  [show with all ESTs]
    Unigene Representative Sequence: NM_022662
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000427997 ENST00000341068(uc002thi.3) ENST00000462785 ENST00000464695
    ENST00000485325 ENST00000482177 ENST00000451367 ENST00000489177 ENST00000467878

    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate ANAPC1 (see all 15):
    hsa-miR-548j hsa-miR-548w hsa-miR-495 hsa-miR-559 hsa-miR-520d-5p hsa-miR-548i hsa-miR-548h hsa-miR-548c-5p
    SwitchGear 3'UTR luciferase reporter plasmidANAPC1 3' UTR sequence
    Inhib. RNA
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    GenScript: all cDNA clones in your preferred vector: ANAPC1 (NM_014885)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ANAPC1
    Primer
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      QuantiTect SYBR Green Assays in human, mouse, rat ANAPC1
      QuantiFast Probe-based Assays in human, mouse, rat ANAPC1

    Additional mRNA sequence: 

    AJ278357.1 AK023807.1 AK094527.1 AL832013.1 BC005089.1 BC104902.1 BC104904.1 DQ786207.1 
    DQ786300.1 

    17 DOTS entries:

    DT.444938  DT.91830605  DT.100661686  DT.96085302  DT.75112682  DT.95272962  DT.92445357  DT.97808402 
    DT.99933220  DT.100037296  DT.115253  DT.120965851  DT.413695  DT.100790642  DT.120947417  DT.440961 
    DT.95272966 

    Selected AceView cDNA sequences (see all 172):

    BU738726 CA307897 BQ216906 AI763329 AL118590 CR623206 AW340292 BP369148 
    BM561568 BP361118 BX282668 BM701674 AA632002 AW500857 BX282336 BU685165 
    BQ706805 BM855797 AI421612 AW877778 AI336971 BC005089 AA516274 BP431334 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ANAPC1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CTGGCCTGCT
    ANAPC1 Expression
    About this image

    ANAPC1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ANAPC1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.436527
        Pathway & Disease-focused RT2 Profiler PCR Array including ANAPC1: 
              Adherens Junctions in human mouse rat

    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for ANAPC1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat ANAPC1
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ANAPC1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for ANAPC1 gene from Selected species (see all 18)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Anapc11 , 5 anaphase promoting complex subunit 11, 5 87.93(n)1
    92.39(a)1
      2 (62.63 cM)5
    172221  NM_008569.21  NP_032595.21 
     1286101045 
    chicken
    (Gallus gallus)
    Aves ANAPC11 anaphase promoting complex subunit 1 76.53(n)
    81.9(a)
      421228  XM_419303.4  XP_419303.3 
    lizard
    (Anolis carolinensis)
    Reptilia ANAPC16
    anaphase promoting complex subunit 1
    84(a)
    1 ↔ 1
    GL343437.1(295181-353098)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.163382 Transcribed sequence with moderate similarity to protein more 78.96(n)    BX706554.1 
    zebrafish
    (Danio rerio)
    Actinopterygii anapc11 anaphase promoting complex subunit 1 65.73(n)
    68.41(a)
      568795  XM_001921133.2  XP_001921168.2 
    fruit fly
    (Drosophila melanogaster)
    Insecta shtd1 shattered 46.97(n)
    39.07(a)
      32473  NM_132797.2  NP_573025.2 
    worm
    (Caenorhabditis elegans)
    Secernentea mat-26
    Protein MAT-2 (mat-2) mRNA, complete cds
    19(a)
    1 ↔ 1
    II(11112719-11120800) WBGene00003133
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes APC1(YNL172W)4 Largest subunit of the Anaphase-Promoting Complex/Cyclosome more   --   14(310636-315882) 855549  NP_014227.1 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons EMB27711 EMB2771 45.78(n)
    35.82(a)
      830439  NM_120638.2  NP_196175.1 
    rice
    (Oryza sativa)
    Liliopsida Os05g03543001 Os05g0354300 49.44(n)
    39.64(a)
      4338511  NM_001061820.1  NP_001055285.1 


    ENSEMBL Gene Tree for ANAPC1 (if available)
    TreeFam Gene Tree for ANAPC1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

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    Paralogs for ANAPC1 gene

    ANAPC1 for paralogs           About GeneDecksing


    Selected Pseudogenes.org Pseudogenes for ANAPC1 (see all 11)
    PGOHUM00000240131 PGOHUM00000240133 PGOHUM00000259739 PGOHUM00000240237 PGOHUM00000259756


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ANAPC1 (see all 1960)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1473357131,2
    --112038490(+) GGGCAC/TAGGGA 1 -- int10--------
    rs1399660391,2
    --112038528(+) CTGGCA/GTAAGA 1 -- int10--------
    rs1498380421,2
    C--112038598(+) TACTTC/TGGGCC 1 -- int10--------
    rs134225871,2
    C--112038728(+) GGTGAA/GAGCCA 1 -- int10--------
    rs1447978881,2
    C--112038776(+) AATTG-/ATTT  
            
    TATTT
    1 -- int10--------
    rs1411818451,2
    C--112039046(+) GAGAGC/TGAAGA 1 -- ut310--------
    rs1852916121,2
    --112039197(+) CCCATC/TGTGCC 1 -- ut310--------
    rs1885594651,2
    --112039414(+) AGGATA/GTGGAA 1 -- ut310--------
    rs1932434001,2
    --112039649(+) TATGGA/CTTGTC 1 -- ut310--------
    rs1998148081,2
    C--112039801(+) TTTCTC/TGCAAT 1 -- ut310--------

    HapMap Linkage Disequilibrium report for ANAPC1 (112523848 - 112642267 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for ANAPC1 (see all 16):    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv215083CNV Loss16902084
    nsv874863CNV Loss21882294
    nsv874862CNV Loss21882294
    nsv428402CNV Loss18775914
    nsv521956CNV Loss19592680
    esv26491CNV Gain19812545
    dgv4278n71CNV Gain21882294
    nsv10127CNV Gain18304495
    dgv4277n71CNV Gain21882294
    nsv834333CNV Gain17160897

    Human Gene Mutation Database (HGMD): ANAPC1
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing ANAPC1
    DNA2.0 Custom Variant and Variant Library Synthesis for ANAPC1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 608473    OMIM disorders: --

    9 diseases for ANAPC1:    
    About MalaCards
    nicotine dependence    cytomegalovirus infection    brain cancer    nasopharyngitis
    hepatocellular carcinoma    obesity    lung cancer    malaria
    neuronitis


    ANAPC1 for disorders           About GeneDecksing

    2 Novoseek inferred disease relationships for ANAPC1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tumors 8.26 2 10992296 (1)
    cancer 5.42 1 11179667 (1)

    Human Genome Epidemiology (HuGE) Navigator: ANAPC1 (1 document)

    Export disorders for ANAPC1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ANAPC1 gene, integrated from 10 sources (see all 86):
    (articles sorted by number of sources associating them with ANAPC1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Characterisation of the human APC1, the largest subunit of the anaphase-promoting complex. (PubMed id 11179667)1, 2, 3, 9 Joergensen P.M....Hoeoeg C. (Gene 2001)
    2. Mechanism of ubiquitin-chain formation by the human anaphase- promoting complex. (PubMed id 18485873)1, 2 Jin L.... Rape M. (Cell 2008)
    3. Localization of the coactivator Cdh1 and the cullin subunit Apc2 in a cryo-electron microscopy model of vertebrate APC/C. (PubMed id 16364912)1, 2 Dube P.... Stark H. (Mol. Cell 2005)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    6. Mitotic regulation of the human anaphase-promoting complex by phosphorylation. (PubMed id 14657031)1, 2 Kraft C....Peters J.-M. (EMBO J. 2003)
    7. Protein interaction network of the mammalian Hippo pathway reveals mechanisms of kinase-phosphatase interactions. (PubMed id 24255178)1 Couzens A.L....Gingras A.C. (Sci Signal 2013)
    8. The G2/M regulator histone demethylase PHF8 is targeted for degradation by the anaphase-promoting complex containing CDC20. (PubMed id 23979597)1 Lim H.J....Shi Y. (Mol. Cell. Biol. 2013)
    9. The phosphatase-transcription activator EYA1 is targeted by anaphase-promoting complex/Cdh1 for degradation at M-to-G1 transition. (PubMed id 23263983)1 Sun J....Xu P.X. (Mol. Cell. Biol. 2013)
    10. Why do cellular proteins linked to K63-polyubiquitin chains not associate with proteasomes? (PubMed id 23314748)1 Nathan J.A....Goldberg A.L. (EMBO J. 2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 64682 HGNC: 19988 AceView: ANAPC1 Ensembl:ENSG00000153107 euGenes: HUgn64682
    ECgene: ANAPC1 Kegg: 64682 H-InvDB: ANAPC1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for ANAPC1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for ANAPC1 gene:
    Search GeneIP for patents involving ANAPC1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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