Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ANAPC1 Gene

protein-coding   GIFtS: 59
GCID: GC02M112523

Anaphase Promoting Complex Subunit 1

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Anaphase Promoting Complex Subunit 11 2     TSG242 3
Cyclosome Subunit 12 3     MCPR2
Mitotic Checkpoint Regulator2 3     Anaphase-Promoting Complex 1 (Meiotic Checkpoint Regulator)2
Testis-Specific Gene 24 Protein2 3     Anaphase-Promoting Complex Subunit 12
APC12 3     

External Ids:    HGNC: 199881   Entrez Gene: 646822   Ensembl: ENSG000001531077   OMIM: 6084735   UniProtKB: Q9H1A43   

Export aliases for ANAPC1 gene to outside databases

Previous GC identifers: GC02M110445 GC02M112430 GC02M112621 GC02M112242 GC02M087019


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for ANAPC1 Gene:
This gene encodes a subunit of the anaphase-promoting complex. This complex is an E3 ubiquitin ligase that
regulates progression through the metaphase to anaphase portion of the cell cycle by ubiquitinating proteins
which targets them for degradation. (provided by RefSeq, Dec 2011)

GeneCards Summary for ANAPC1 Gene: 
ANAPC1 (anaphase promoting complex subunit 1) is a protein-coding gene. Diseases associated with ANAPC1 include nicotine dependence, and cytomegalovirus infection, and among its related super-pathways are Mitotic Spindle Checkpoint and Antigen processing: Ubiquitination & Proteasome degradation.

UniProtKB/Swiss-Prot: APC1_HUMAN, Q9H1A4
Function: Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin
ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by
mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of
'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked
polyubiquitin chains

Gene Wiki entry for ANAPC1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000002.11  NT_022135.16  NC_018913.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ANAPC1 gene promoter:
         GR   Nkx3-1   Nkx3-1 v4   Nkx3-1 v1   AREB6   Nkx3-1 v2   Nkx3-1 v3   GR-alpha   ZIC2/Zic2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): ANAPC1 promoter sequence
   Search SABiosciences Chromatin IP Primers for ANAPC1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ANAPC1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q12.1   Ensembl cytogenetic band:  2q13   HGNC cytogenetic band: 2q12.1

ANAPC1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ANAPC1 gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02M112523:  view genomic region     (about GC identifiers)

Start:
112,523,848 bp from pter      End:
112,642,267 bp from pter
Size:
118,420 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: APC1_HUMAN, Q9H1A4 (See protein sequence)
Recommended Name: Anaphase-promoting complex subunit 1  
Size: 1944 amino acids; 216500 Da
Subunit: The APC/C is composed of at least 12 subunits
Secondary accessions: Q2M3H8 Q9BSE6 Q9H8D0

Explore the universe of human proteins at neXtProt for ANAPC1: NX_Q9H1A4

Explore proteomics data for ANAPC1 at MOPED 

Post-translational modifications:

  • UniProtKB: Phosphorylated. Phosphorylation on Ser-355 occurs specifically during mitosis
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9H1A4

  • ANAPC1 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    ANAPC1 Protein Expression
    REFSEQ proteins: NP_073153.1  
    ENSEMBL proteins: 
     ENSP00000396695   ENSP00000339109   ENSP00000405375  
    Reactome Protein details: Q9H1A4
    Human Recombinant Protein Products for ANAPC1: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    Browse OriGene Protein Over-expression Lysates
    OriGene Custom MassSpec 
    OriGene Custom Protein Services for ANAPC1
    GenScript Custom Purified and Recombinant Proteins Services for ANAPC1
    Novus Biologicals ANAPC1 Proteins
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for ANAPC1 

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus ----
    GO:0005654nucleoplasm TAS--
    GO:0005680anaphase-promoting complex IDA16364912
    GO:0005829cytosol TAS--

    ANAPC1 for ontologies           About GeneDecksing



    ANAPC1 Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    OriGene Antibodies for ANAPC1
    OriGene Custom Antibody Services for ANAPC1
    GenScript Custom Superior Antibodies Services for ANAPC1
    Novus Biologicals ANAPC1 Antibodies
    Abcam antibodies for ANAPC1
    Cloud-Clone Corp. Antibodies for ANAPC1 
    ThermoFisher Antibodies for ANAPC1
    LSBio Antibodies in human, mouse, rat for ANAPC1 

    Assay Products for ANAPC1: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for ANAPC1
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for ANAPC1
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for ANAPC1 
    Cloud-Clone Corp. CLIAs for ANAPC1


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    ANAPC: Anaphase promoting complex subunits

    1 InterPro protein domain:
     IPR024990 Apc1

    Graphical View of Domain Structure for InterPro Entry Q9H1A4

    ProtoNet protein and cluster: Q9H1A4

    UniProtKB/Swiss-Prot: APC1_HUMAN, Q9H1A4
    Similarity: Belongs to the APC1 family
    Similarity: Contains 4 PC repeats


    ANAPC1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: APC1_HUMAN, Q9H1A4
    Function: Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin
    ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by
    mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of
    'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked
    polyubiquitin chains

         Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
         
    ANAPC1 for ontologies           About GeneDecksing


    Phenotypes:
         5 GenomeRNAi human phenotypes for ANAPC1:
     Cell cycle / mitosis defect  Increased S DNA content  Increased cell death HMECs cel  Increased number of mitotic ce 
     Synthetic lethal with Ras 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for ANAPC1 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for ANAPC1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for ANAPC1 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for ANAPC1 

    miRNA
    Products:
        
    miRTarBase miRNAs that target ANAPC1:
    hsa-let-7b (MIRT001653)

    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ANAPC1
    8/15 QIAGEN miScript miRNA Assays for microRNAs that regulate ANAPC1 (see all 15):
    hsa-miR-548j hsa-miR-548w hsa-miR-495 hsa-miR-559 hsa-miR-520d-5p hsa-miR-548i hsa-miR-548h hsa-miR-548c-5p
    SwitchGear 3'UTR luciferase reporter plasmidANAPC1 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for ANAPC1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ANAPC1

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for ANAPC1
    Sirion Biotech Customized adenovirus for overexpression of ANAPC1

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for ANAPC1 (see all 5)
    OriGene ORF clones in mouse, rat for ANAPC1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: ANAPC1 (NM_014885)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ANAPC1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ANAPC1

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for ANAPC1
    Search LifeMap BioReagents cell lines for ANAPC1
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ANAPC1


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for ANAPC1 About   (see all 22)                                                                                              See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase
    Mitotic Spindle Checkpoint0.95
    APC/C:Cdc20 mediated degradation of Cyclin B0.76
    Inactivation of APC/C via direct inhibition of the APC/C complex0.95
    Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase0.75
    Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components0.95
    Phosphorylation of the APC/C0.73
    APC-Cdc20 mediated degradation of Nek2A0.78
    Common schema of ubiquitination0.36
    2Antigen processing: Ubiquitination & Proteasome degradation
    Antigen processing: Ubiquitination & Proteasome degradation0.83
    Ubiquitin mediated proteolysis0.36
    Class I MHC mediated antigen processing & presentation0.83
    3CDK-mediated phosphorylation and removal of Cdc6
    APC/C:Cdc20 mediated degradation of mitotic proteins0.94
    Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins0.93
    Cdc20:Phospho-APC/C mediated degradation of Cyclin A0.94
    APC/C:Cdc20 mediated degradation of Securin0.93
    Regulation of APC/C activators between G1/S and early anaphase0.94
    APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G10.93
    APC/C-mediated degradation of cell cycle proteins0.94
    Autodegradation of Cdh1 by Cdh1:APC/C0.91
    4M Phase
    Mitotic Anaphase0.94
    M Phase0.88
    Separation of Sister Chromatids0.94
    Mitotic M-M/G1 phases0.88
    Mitotic Metaphase and Anaphase0.94
    5Cell Cycle
    Cell Cycle, Mitotic0.84
    Cell Cycle0.84

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    5/9 EMD Millipore Pathways for ANAPC1 (see all 9)
        Cell cycle Role of APC in cell cycle regulation
    Meiosis
    Cell cycle Regulation of G1/S transition (part 1)
    Development TGF-beta receptor signaling
    Signal transduction PKA signaling

    5/6 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for ANAPC1 (see all 6)
        Activation of PKA through GPCR
    Remodeling of Adherens Junctions
    cAMP Pathway
    CDC42 Pathway
    Mitotic Roles of Polo Like Kinases

    5/7 GeneGo (Thomson Reuters) Pathways for ANAPC1 (see all 7)
        Cell cycle Role of APC in cell cycle regulation
    G-protein signaling G-Protein alpha-s signaling cascades
    Signal transduction PKA signaling
    Cell cycle Regulation of G1/S transition (part 1)
    Cell cycle Spindle assembly and chromosome separation

    1 BioSystems Pathway for ANAPC1
        TGF-beta Receptor Signaling Pathway

    5/28        Reactome Pathways for ANAPC1 (see all 28)
        APC/C:Cdc20 mediated degradation of mitotic proteins
    Cell Cycle
    M Phase
    Phosphorylation of the APC/C
    Mitotic Spindle Checkpoint


    5         Kegg Pathways  (Kegg details for ANAPC1):
        Cell cycle
    Oocyte meiosis
    Ubiquitin mediated proteolysis
    Progesterone-mediated oocyte maturation
    HTLV-I infection

    UniProtKB/Swiss-Prot: APC1_HUMAN, Q9H1A4
    Pathway: Protein modification; protein ubiquitination


    ANAPC1 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ANAPC1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/862 Interacting proteins for ANAPC1 (Q9H1A42, 3 ENSP000003391094) via UniProtKB, MINT, STRING, and/or I2D (see all 862)

    InteractantInteraction Details
    GeneCardExternal ID(s)
    ANAPC7Q9UJX32, 3, ENSP000003943944MINT-8412994 MINT-7947479 I2D: score=2 STRING: ENSP00000394394
    CDC16Q130422, 3, ENSP000003485544MINT-7945693 MINT-7947479 I2D: score=2 STRING: ENSP00000348554
    CDC23Q9UJX22, 3, ENSP000003783504MINT-7945693 MINT-7947479 I2D: score=2 STRING: ENSP00000378350
    BUB3O436842, 3, ENSP000003578584MINT-7945693 MINT-7947479 I2D: score=1 STRING: ENSP00000357858
    ANAPC2Q9UJX62, 3, ENSP000003140044MINT-7947479 I2D: score=2 STRING: ENSP00000314004
    About this table

    Gene Ontology (GO): 5/9 biological process terms (GO ID links to tree view) (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000278mitotic cell cycle TAS--
    GO:0007067mitosis IEA--
    GO:0007094mitotic spindle assembly checkpoint TAS--
    GO:0031145anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process TAS--
    GO:0051301cell division IEA--

    ANAPC1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ANAPC1 (APC1)

    Search CenterWatch for drugs/clinical trials and news about ANAPC1 / APC1

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for ANAPC1 gene: 
    NM_022662.3  

    Unigene Cluster for ANAPC1:

    Anaphase promoting complex subunit 1
    Hs.436527  [show with all ESTs]
    Unigene Representative Sequence: NM_022662
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000427997 ENST00000341068(uc002thi.3) ENST00000462785 ENST00000464695
    ENST00000485325 ENST00000482177 ENST00000451367 ENST00000489177 ENST00000467878

    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ANAPC1
    8/15 QIAGEN miScript miRNA Assays for microRNAs that regulate ANAPC1 (see all 15):
    hsa-miR-548j hsa-miR-548w hsa-miR-495 hsa-miR-559 hsa-miR-520d-5p hsa-miR-548i hsa-miR-548h hsa-miR-548c-5p
    SwitchGear 3'UTR luciferase reporter plasmidANAPC1 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for ANAPC1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ANAPC1
    Clone
    Products:
         
    OriGene clones in human, mouse for ANAPC1 (see all 5)
    OriGene ORF clones in mouse, rat for ANAPC1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: ANAPC1 (NM_014885)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ANAPC1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ANAPC1
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for ANAPC1
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat ANAPC1
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ANAPC1
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ANAPC1

    Additional mRNA sequence: 

    AJ278357.1 AK023807.1 AK094527.1 AL832013.1 BC005089.1 BC104902.1 BC104904.1 DQ786207.1 
    DQ786300.1 

    17 DOTS entries:

    DT.444938  DT.91830605  DT.100661686  DT.96085302  DT.75112682  DT.95272962  DT.92445357  DT.97808402 
    DT.99933220  DT.100037296  DT.115253  DT.120965851  DT.413695  DT.100790642  DT.120947417  DT.440961 
    DT.95272966 

    24/172 AceView cDNA sequences (see all 172):

    AL118590 BX282668 BM701674 AA632002 AW500857 BX282336 BU685165 BQ706805 
    BM855797 AI421612 AW877778 AI336971 BC005089 AA516274 BP431334 BE812786 
    BU680538 AA355729 AI380639 CA454245 AA470001 AA412217 BU633528 AI651110 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ANAPC1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CTGGCCTGCT
    ANAPC1 Expression
    About this image


    See ANAPC1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ANAPC1

    SOURCE GeneReport for Unigene cluster: Hs.436527
        SABiosciences Expression via Pathway-Focused PCR Array including ANAPC1: 
              Adherens Junctions in human mouse rat

    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for ANAPC1
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat ANAPC1
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ANAPC1
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ANAPC1
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ANAPC1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for ANAPC1 gene from 10/18 species (see all 18)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Anapc11 , 5 anaphase promoting complex subunit 11, 5 87.93(n)1
    92.39(a)1
      2 (62.63 cM)5
    172221  NM_008569.21  NP_032595.21 
     1286101045 
    chicken
    (Gallus gallus)
    Aves ANAPC11 anaphase promoting complex subunit 1 76.57(n)
    81.9(a)
      421228  XM_419303.3  XP_419303.3 
    lizard
    (Anolis carolinensis)
    Reptilia ANAPC16
    anaphase promoting complex subunit 1
    84(a)
    1 ↔ 1
    GL343437.1(295181-353098)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.163382 Transcribed sequence with moderate similarity to protein more 78.96(n)    BX706554.1 
    zebrafish
    (Danio rerio)
    Actinopterygii anapc11 anaphase promoting complex subunit 1 65.59(n)
    68.37(a)
      568795  XM_001921133.1  XP_001921168.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta shtd1 shattered 46.81(n)
    38.84(a)
      32473  NM_132797.2  NP_573025.2 
    worm
    (Caenorhabditis elegans)
    Secernentea mat-26
    Protein MAT-2
    20(a)
    1 ↔ 1
    II(11112719-11120800)
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes APC1(YNL172W)4 Largest subunit of the Anaphase-Promoting Complex/Cyclosome more   --   14(310636-315882) 855549  NP_014227.1 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons EMB27711 anaphase-promoting complex subunit 1 45.49(n)
    35.26(a)
      830439  NM_120638.2  NP_196175.1 
    rice
    (Oryza sativa)
    Liliopsida Os05g03543001 hypothetical protein 49.25(n)
    39.51(a)
      4338511  NM_001061820.1  NP_001055285.1 


    ENSEMBL Gene Tree for ANAPC1 (if available)
    TreeFam Gene Tree for ANAPC1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ANAPC1 gene

    ANAPC1 for paralogs           About GeneDecksing


    5/11 Pseudogenes.org Pseudogenes for ANAPC1 (see all 11)
    PGOHUM00000240131 PGOHUM00000240133 PGOHUM00000259739 PGOHUM00000240237 PGOHUM00000259756


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1960 SNPs in ANAPC1 are shown (see all 1960)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1473357131,2
    --112038490(+) GGGCAC/TAGGGA 1 -- int10--------
    rs1399660391,2
    --112038528(+) CTGGCA/GTAAGA 1 -- int10--------
    rs1498380421,2
    C--112038598(+) TACTTC/TGGGCC 1 -- int10--------
    rs134225871,2
    C--112038728(+) GGTGAA/GAGCCA 1 -- int10--------
    rs1447978881,2
    C--112038776(+) AATTG-/ATTT  
            
    TATTT
    1 -- int10--------
    rs1411818451,2
    C--112039046(+) GAGAGC/TGAAGA 1 -- ut310--------
    rs1852916121,2
    --112039197(+) CCCATC/TGTGCC 1 -- ut310--------
    rs1885594651,2
    --112039414(+) AGGATA/GTGGAA 1 -- ut310--------
    rs1932434001,2
    --112039649(+) TATGGA/CTTGTC 1 -- ut310--------
    rs1998148081,2
    C--112039801(+) TTTCTC/TGCAAT 1 -- ut310--------

    HapMap Linkage Disequilibrium report for ANAPC1 (112523848 - 112642267 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10/16 variations for ANAPC1 (see all 16):    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv215083CNV Loss16902084
    nsv874863CNV Loss21882294
    nsv874862CNV Loss21882294
    nsv428402CNV Loss18775914
    nsv521956CNV Loss19592680
    esv26491CNV Gain19812545
    dgv4278n71CNV Gain21882294
    nsv10127CNV Gain18304495
    dgv4277n71CNV Gain21882294
    nsv834333CNV Gain17160897


    Human Gene Mutation Database (HGMD): ANAPC1
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing ANAPC1
    DNA2.0 Custom Variant and Variant Library Synthesis for ANAPC1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 608473    OMIM disorders: --

    8 diseases for ANAPC1:    About MalaCards
    nicotine dependence    cytomegalovirus infection    nasopharyngitis    colon cancer
    gastric cancer    hepatocellular carcinoma    lung cancer    neuronitis


    ANAPC1 for disorders           About GeneDecksing

    2 Novoseek inferred disease relationships for ANAPC1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tumors 8.26 2 10992296 (1)
    cancer 5.42 1 11179667 (1)

    Human Genome Epidemiology (HuGE) Navigator: ANAPC1 (1 document)

    Export disorders for ANAPC1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ANAPC1 gene, integrated from 9 sources (see all 81):
    (articles sorted by number of sources associating them with ANAPC1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Characterisation of the human APC1, the largest subunit of the anaphase-promoting complex. (PubMed id 11179667)1, 2, 3, 9 Joergensen P.M....Hoeoeg C. (2001)
    2. Mechanism of ubiquitin-chain formation by the human anaphase-promoting complex. (PubMed id 18485873)1, 2 Jin L....Rape M. (2008)
    3. Localization of the coactivator Cdh1 and the cullin subunit Apc2 in a cryo-electron microscopy model of vertebrate APC/C. (PubMed id 16364912)1, 2 Dube P.... Stark H. (2005)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    6. Mitotic regulation of the human anaphase-promoting complex by phosphorylation. (PubMed id 14657031)1, 2 Kraft C....Peters J.-M. (2003)
    7. The phosphatase-transcription activator EYA1 is target ed by anaphase-promoting complex/Cdh1 for degradation at M-to-G1 transition. (PubMed id 23263983)1 Sun J....Xu P.X. (2013)
    8. Why do cellular proteins linked to K63-polyubiquitin c hains not associate with proteasomes? (PubMed id 23314748)1 Nathan J.A....Goldberg A.L. (2013)
    9. Regulation of Rad17 protein turnover unveils an impact of Rad17-APC cascade in breast carcinogenesis and treatment. (PubMed id 23637229)1 Zhou Z....Wan Y. (2013)
    10. Transcriptional intermediary factor 1g binds to the an aphase-promoting complex/cyclosome and promotes mitosis. (PubMed id 23160376)1 Sedgwick G.G....Turnell A.S. (2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 64682 HGNC: 19988 AceView: ANAPC1 Ensembl:ENSG00000153107 euGenes: HUgn64682
    ECgene: ANAPC1 Kegg: 64682 H-InvDB: ANAPC1

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ANAPC1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for ANAPC1 gene:
    Search GeneIP for patents involving ANAPC1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Protease Activity Assays and Reagents   Browse Recombinant/Natural Proteins  
     Browse Stem Cell Products   Browse Tocris Biochemicals & Compounds  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for ANAPC1   OriGene RNAi products in human, mouse, rat for ANAPC1  
     Browse OriGene qPCR primer pairs and template standards   Browse OriGene Protein Over-expression Lysates  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for ANAPC1  
     OriGene qSTAR qPCR primer pairs in human, mouse for ANAPC1   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for ANAPC1   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for ANAPC1   OriGene Custom Protein Services for ANAPC1  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat ANAPC1
     QIAGEN SeqTarget long-range PCR primers for resequencing ANAPC1
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ANAPC1
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ANAPC1
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ANAPC1
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ANAPC1
     GenScript Custom Purified and Recombinant Proteins Services for ANAPC1 GenScript cDNA clones with any tag delivered in your preferred vector for ANAPC1
     GenScript Custom Assay Services for ANAPC1 GenScript Custom Superior Antibodies Services for ANAPC1
     GenScript Custom overexpressing Cell Line Services for ANAPC1 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in ANAPC1 promoter
     Search Chromatin IP Primers for ANAPC1
     RT2 qPCR Primer Assay in human, mouse, rat ANAPC1
     Search GNC Networks for ANAPC1
     SABiosciences PCR Arrays including human, mouse, rat ANAPC1
     Search Tocris compounds for ANAPC1 (APC1)
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     ANAPC1 antibodies
     ANAPC1 proteins
     Antibodies for ANAPC1
     See all of Abcam's Antibodies, Kits and Proteins for ANAPC1
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     Proteins for ANAPC1
     Antibodies for ANAPC1
     ELISAs for ANAPC1
     CLIAs for ANAPC1
     Search LifeMap BioReagents cell lines for ANAPC1
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ANAPC1
     SwitchGear 3'UTR luciferase reporter plasmids for ANAPC1
     SwitchGear Promoter luciferase reporter plasmids for ANAPC1
     ThermoFisher Antibodies for ANAPC1
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ANAPC1
     inGenious Targeting Laboratory - Custom generated mouse model solutions for ANAPC1
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for ANAPC1
    Customized:
     lentivirus for stable overexpression
     lentivirus expression plasmids for stable overexpression
     adenovirus for overexpression of ANAPC1
     LSBio Antibodies in human, mouse, rat for ANAPC1
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

    View Random Gene

    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      ANAPC1 gene at Home site.
    hostname: 356977-web1.xennexinc.com index build: 106 solr: 1.4