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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ANAPC1 Gene

protein-coding   GIFtS: 59
GCID: GC02M112523

anaphase promoting complex subunit 1
 Explore 7 diseases affiliated with
ANAPC1 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for ANAPC1    

Aliases
for ANAPC1 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Anaphase Promoting Complex Subunit 11 2     Mitotic Checkpoint Regulator2 3
APC11 2 3     Testis-Specific Gene 24 Protein2 3
TSG241 2 3     Anaphase-Promoting Complex 1 (Meiotic Checkpoint Regulator)2
MCPR1 2     Anaphase-Promoting Complex Subunit 12
Cyclosome Subunit 12 3     

External Ids:    HGNC: 199881   Entrez Gene: 646822   Ensembl: ENSG000001531077   OMIM: 6084735   UniProtKB: Q9H1A43   

Export aliases for ANAPC1 gene to outside databases

Previous GC identifers: GC02M110445 GC02M112430 GC02M112621 GC02M112242 GC02M087019


Summaries
for ANAPC1 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for ANAPC1:
This gene encodes a subunit of the anaphase-promoting complex. This complex is an E3 ubiquitin ligase that regulates
progression through the metaphase to anaphase portion of the cell cycle by ubiquitinating proteins which targets them
for degradation. (provided by RefSeq, Dec 2011)

UniProtKB/Swiss-Prot: APC1_HUMAN, Q9H1A4
Function: Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase
that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating
ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked
polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains

Gene Wiki entry for ANAPC1


Genomic Views
for ANAPC1 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000002.11  NC_018913.1  NT_022135.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ANAPC1 gene promoter:
         GR   Nkx3-1   Nkx3-1 v4   Nkx3-1 v1   AREB6   Nkx3-1 v2   Nkx3-1 v3   GR-alpha   ZIC2/Zic2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): ANAPC1 promoter sequence
   Search SABiosciences Chromatin IP Primers for ANAPC1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ANAPC1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q12.1   Ensembl cytogenetic band:  2q13   HGNC cytogenetic band: 2q12.1

ANAPC1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ANAPC1 gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02M112523:  view genomic region     (about GC identifiers)

Start:
 112,523,848 bp from pter      End:
 112,642,267 bp from pter
Size:
 118,420 bases      Orientation:
 minus strand

Proteins
for ANAPC1 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: APC1_HUMAN, Q9H1A4 (See protein sequence)
Recommended Name: Anaphase-promoting complex subunit 1  
Size: 1944 amino acids; 216500 Da
Subunit: The APC/C is composed of at least 12 subunits
Secondary accessions: Q2M3H8 Q9BSE6 Q9H8D0

Explore the universe of human proteins at neXtProt for ANAPC1: NX_Q9H1A4

Post-translational modifications:

  • Phosphorylated. Phosphorylation on Ser-355 occurs specifically during mitosis1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q9H1A4

    • ANAPC1 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_073153.1  
    ENSEMBL proteins: 
     ENSP00000396695   ENSP00000339109   ENSP00000405375  
    Reactome Protein details: Q9H1A4
    Human Recombinant Protein Products: 
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    Novus Biologicals ANAPC1 Proteins
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for ANAPC1

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus ----
    GO:0005654nucleoplasm TAS--
    GO:0005680anaphase-promoting complex IDA16364912
    GO:0005829cytosol TAS--


    ANAPC1 for ontologies           About GeneDecksing



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    Uscn ELISAs and CLIAs for ANAPC1

    Protein Domains /
    Families
    for ANAPC1 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    ANAPC1 for domains           About GeneDecksing

    1 InterPro domain/family:
     IPR024990 Apc1

    Graphical View of Domain Structure for InterPro Entry Q9H1A4

    ProtoNet protein and cluster: Q9H1A4

    UniProtKB/Swiss-Prot: APC1_HUMAN, Q9H1A4
    Similarity: Belongs to the APC1 family
    Similarity: Contains 4 PC repeats


    Function
    for ANAPC1 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: APC1_HUMAN, Q9H1A4
    Function: Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase
    that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating
    ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked
    polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains

    miRNA
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    hsa-let-7b (MIRT001653)

    OriGene 3'-UTR Clone: ANAPC1
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ANAPC1
    8/15 QIAGEN miScript miRNA Assays for microRNAs that regulate ANAPC1 (see all 15):
    hsa-miR-548j hsa-miR-548w hsa-miR-495 hsa-miR-559 hsa-miR-520d-5p hsa-miR-548i hsa-miR-548h hsa-miR-548c-5p
    SwitchGear 3'UTR luciferase reporter plasmid: ANAPC1 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ANAPC1 (see all 7)
    OriGene shRNA RFP: ANAPC1
    OriGene siRNA: ANAPC1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ANAPC1

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for ANAPC1

    Clone
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    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ANAPC1 (see all 3)
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    GenScript: all cDNA clones in your preferred vector: ANAPC1 (NM_014885)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ANAPC1 

    Cell Line
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    Search LifeMap BioReagents cell lines for ANAPC1

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ANAPC1

    Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----


    ANAPC1 for ontologies           About GeneDecksing


    5 GenomeRNAi human phenotypes for ANAPC1:
     Cell cycle / mitosis defect  Increased S DNA content  Increased cell death HMECs cel  Increased number of mitotic ce 
     Synthetic lethal with Ras 


    Pathways & Interactions
    for ANAPC1 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/22 super-pathways (see all 22) About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Ubiquitinated Orc1 is degraded by the proteasome
    8/15 pathways (see all 15)
    		APC/C:Cdh1-mediated degradation of Skp20.74
    		APC/C:Cdc20 mediated degradation of mitotic proteins0.69
    		APC/C:Cdc20 mediated degradation of Securin0.74
    		APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G10.69
    		Degradation of multiubiquitinated Securin0.74
    		Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins0.68
    		Autodegradation of Cdh1 by Cdh1:APC/C0.70
    		Regulation of APC/C activators between G1/S and early anaphase0.62
    2APC-Cdc20 mediated degradation of Nek2A
    8/10 pathways (see all 10)
    		Degradation of multiubiquitinated Nek2A1.00
    		Degradation of multiubiquitinated Cyclin B0.76
    		APC-Cdc20 mediated degradation of Nek2A1.00
    		Mitotic Spindle Checkpoint0.75
    		Inactivation of APC/C via direct inhibition of the APC/C complex0.78
    		Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase0.60
    		Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components0.78
    		Phosphorylation of the APC/C0.54
    3M Phase
    		M Phase1.00
    		Mitotic Anaphase0.85
    		Mitotic M-M/G1 phases0.88
    		Separation of Sister Chromatids0.80
    		Mitotic Metaphase and Anaphase0.85
    4Antigen processing: Ubiquitination & Proteasome degradation
    		Antigen processing: Ubiquitination & Proteasome degradation1.00
    		Polyubiquitination of substrate0.75
    		Class I MHC mediated antigen processing & presentation0.83
    		Ubiquitin mediated proteolysis0.36
    5Cell cycle_Spindle assembly and chromosome separation
    		Cell cycle_Spindle assembly and chromosome separation1.00
    		Cell cycle Spindle assembly and chromosome separation0.94

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    5/9 EMD Millipore Pathways for ANAPC1 (see all 9)
        Cell cycle Role of APC in cell cycle regulation
    Meiosis
    Cell cycle Regulation of G1/S transition (part 1)
    Development TGF-beta receptor signaling
    Signal transduction PKA signaling

    5/6 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for ANAPC1 (see all 6)
        Activation of PKA through GPCR
    Remodeling of Adherens Junctions
    cAMP Pathway
    CDC42 Pathway
    Mitotic Roles of Polo Like Kinases

    5/7 GeneGo (Thomson Reuters) Pathways for ANAPC1 (see all 7)
        Cell cycle Role of APC in cell cycle regulation
    G-protein signaling G-Protein alpha-s signaling cascades
    Signal transduction PKA signaling
    Cell cycle Regulation of G1/S transition (part 1)
    Cell cycle Spindle assembly and chromosome separation

    1 BioSystems Pathway for ANAPC1 
        TGF-beta Receptor Signaling Pathway

    5/36        Reactome Pathways for ANAPC1 (see all 36)
        APC/C:Cdc20 mediated degradation of mitotic proteins
    Phosphorylation of the APC/C
    APC/C:Cdc20 mediated degradation of Securin
    Cdc20:Phospho-APC/C mediated degradation of Cyclin A
    Antigen processing: Ubiquitination & Proteasome degradation


    4         Kegg Pathways  (Kegg details for ANAPC1):
        Cell cycle
    Oocyte meiosis
    Ubiquitin mediated proteolysis
    Progesterone-mediated oocyte maturation

    UniProtKB/Swiss-Prot: APC1_HUMAN, Q9H1A4
    Pathway: Protein modification; protein ubiquitination


    ANAPC1 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ANAPC1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/819 Interacting proteins for ANAPC1 (Q9H1A42, 3 ENSP000003391094) via UniProtKB, MINT, STRING, and/or I2D (see all 819)

    InteractantInteraction Details
    GeneCardExternal ID(s)
    ANAPC7Q9UJX32, 3, ENSP000003943944MINT-8412994 MINT-7947479 I2D: score=2 STRING: ENSP00000394394
    CDC16Q130422, 3, ENSP000003485544MINT-7945693 MINT-7947479 I2D: score=2 STRING: ENSP00000348554
    CDC23Q9UJX22, 3, ENSP000003783504MINT-7945693 MINT-7947479 I2D: score=2 STRING: ENSP00000378350
    BUB3O436842, 3, ENSP000003578584MINT-7945693 MINT-7947479 I2D: score=1 STRING: ENSP00000357858
    ANAPC2Q9UJX62, 3, ENSP000003140044MINT-7947479 I2D: score=2 STRING: ENSP00000314004
    About this table

    Gene Ontology (GO): 5/10 biological process terms (GO ID links to tree view) (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000075cell cycle checkpoint TAS--
    GO:0000278mitotic cell cycle TAS--
    GO:0007067mitosis IEA--
    GO:0007094mitotic cell cycle spindle assembly checkpoint TAS--
    GO:0031145anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process TAS--


    ANAPC1 for ontologies           About GeneDecksing



    Drugs & Compounds
    for ANAPC1 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ANAPC1
    Search CenterWatch for drugs/clinical trials and news about ANAPC1 / APC1 

    Transcripts
    for ANAPC1 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for ANAPC1 gene: 
    NM_022662.3  

    Unigene Cluster for ANAPC1:

    Anaphase promoting complex subunit 1
    Hs.436527  [show with all ESTs]
    Unigene Representative Sequence: NM_022662
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000427997 ENST00000341068(uc002thi.3) ENST00000462785 ENST00000464695
    ENST00000485325 ENST00000482177 ENST00000451367 ENST00000489177 ENST00000467878


    miRNA
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    8/15 QIAGEN miScript miRNA Assays for microRNAs that regulate ANAPC1 (see all 15):
    hsa-miR-548j hsa-miR-548w hsa-miR-495 hsa-miR-559 hsa-miR-520d-5p hsa-miR-548i hsa-miR-548h hsa-miR-548c-5p
    SwitchGear 3'UTR luciferase reporter plasmid: ANAPC1 3' UTR sequence
    Inhib. RNA
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    Clone
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    Primer
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    Additional cDNA sequence: 

    AJ278357.1 AK023807.1 AK094527.1 AL832013.1 BC005089.1 BC104902.1 BC104904.1 DQ786207.1 
    DQ786300.1 

    17 DOTS entries:

    DT.444938  DT.91830605  DT.100661686  DT.96085302  DT.75112682  DT.95272962  DT.92445357  DT.97808402 
    DT.99933220  DT.100037296  DT.115253  DT.120965851  DT.413695  DT.100790642  DT.120947417  DT.440961 
    DT.95272966 

    24/172 AceView cDNA sequences (see all 172):

    AW340292 AW500857 BX282668 BM701674 BP361118 BU680538 AA632002 BM855797 
    BU685165 BQ706805 AL118590 BE812799 BQ446741 BX282336 AK023807 BU633528 
    BU738726 CA307897 BE812786 AW877778 CA454245 AI421612 NM_022662 AU123495 

    GeneLoc Exon Structure


    Expression
    for ANAPC1 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ANAPC1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: CTGGCCTGCT

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image
    See ANAPC1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ANAPC1

    SOURCE GeneReport for Unigene cluster: Hs.436527
        SABiosciences Expression via Pathway-Focused PCR Array including ANAPC1: 
              Adherens Junctions in human mouse rat

    Primer
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    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ANAPC1

    Orthologs
    for ANAPC1 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of eukaryotes.

    Orthologs for ANAPC1 gene from 9/27 species (see all 27)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Anapc11 , 5 anaphase promoting complex subunit 11, 5 87.93(n)1
    92.39(a)1    		   2 (62.63 cM)5
    172221  NM_008569.21  NP_032595.21 
     1286101045 
    chicken
    (Gallus gallus)    		 Aves ANAPC11 anaphase promoting complex subunit 1 76.57(n)
    81.9(a)    		   421228  XM_419303.3  XP_419303.3 
    lizard
    (Anolis carolinensis)    		 Reptilia ANAPC16
    		 --
    		 84(a)
    		 1 ↔ 1
    		 GL343437.1(300650-352522)
    tropical clawed frog
    (Xenopus tropicalis)    		 Amphibia Str.163382 Transcribed sequence with moderate similarity to protein more 78.96(n)    BX706554.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii anapc11 anaphase promoting complex subunit 1 65.59(n)
    68.37(a)    		   568795  XM_001921133.1  XP_001921168.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta shtd1 shattered 46.81(n)
    38.84(a)    		   32473  NM_132797.2  NP_573025.2 
    worm
    (Caenorhabditis elegans)    		 Secernentea mat-26
    		 Metaphase-to-Anaphase Transition defect family mem...
    		 19(a)
    		 1 ↔ 1
    		 II(11112661-11120742)
    thale cress
    (Arabidopsis thaliana)    		 eudicotyledons EMB27711 anaphase-promoting complex subunit 1 45.49(n)
    35.26(a)    		   830439  NM_120638.2  NP_196175.1 
    rice
    (Oryza sativa)    		 Liliopsida Os05g03543001 hypothetical protein 49.25(n)
    39.51(a)    		   4338511  NM_001061820.1  NP_001055285.1 


    ENSEMBL Gene Tree for ANAPC1 (if available)
    TreeFam Gene Tree for ANAPC1 (if available) 

    Paralogs
    for ANAPC1 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ANAPC1 gene

    ANAPC1 for paralogs           About GeneDecksing


    5/11 Pseudogenes.org Pseudogenes for ANAPC1 (see all 11)
    PGOHUM00000240131 PGOHUM00000240133 PGOHUM00000259739 PGOHUM00000240237 PGOHUM00000259756


    Genomic Variants
    for ANAPC1 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1645 NCBI SNPs in ANAPC1 are shown (see all 1645)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 2 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1473357131,2
    		--112524717(+) GGGCAC/TAGGGA 1 -- int10--------
    rs1399660391,2
    		--112524755(+) CTGGCA/GTAAGA 1 -- int10--------
    rs1498380421,2
    		--112524825(+) TACTTC/TGGGCC 1 -- int10--------
    rs134225871,2
    		C,--112524955(+) GGTGAA/GAGCCA 1 -- int10--------
    rs1447978881,2
    		C,--112525003(+) AATTG-/ATTT  
                ATTTG     		1 -- int10--------
    rs1411818451,2
    		--112525273(+) GAGAGC/TGAAGA 1 -- ut310--------
    rs1852916121,2
    		--112525424(+) CCCATC/TGTGCC 1 -- ut310--------
    rs1885594651,2
    		--112525641(+) AGGATA/GTGGAA 1 -- ut310--------
    rs1932434001,2
    		--112525876(+) TATGGA/CTTGTC 1 -- ut310--------
    rs1379992621,2
    		C,F,--112526866(+) GACACG/AGTCAC 1 -- ut312Minor allele frequency- A:0.16NA EU 5349

    HapMap Linkage Disequilibrium report for ANAPC1 (112523848 - 112642267 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 8 variations for ANAPC1
         8 CNVs: 89897 68124 68125 3384 30997 89896 68126 68123
    Human Gene Mutation Database (HGMD): ANAPC1

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    Disorders / Diseases
    for ANAPC1 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    ANAPC1 for disorders           About GeneDecksing

    OMIM gene information: 608473    OMIM disorders: --

    7 diseases for ANAPC1:    About MalaCards
    hepatocellular carcinoma    colon cancer    gastric cancer    nasopharyngitis
    lung cancer    carcinoma    neuronitis

    2 Novoseek disease relationships for ANAPC1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tumors 8.26 2 10992296 (1)
    cancer 5.42 1 11179667 (1)

    Human Genome Epidemiology (HuGE) Navigator: ANAPC1 (1 document)

    Export disorders for ANAPC1 gene to outside databases

    Publications
    for ANAPC1 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ANAPC1 gene, integrated from 9 sources (see all 71):
    (articles sorted by number of sources associating them with ANAPC1)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Characterisation of the human APC1, the largest subunit of the anaphase-promoting complex. (PubMed id 11179667)1, 2, 3, 9 Joergensen P.M....Hoeoeg C. (2001)
    2. Mechanism of ubiquitin-chain formation by the human anaphase-promoting complex. (PubMed id 18485873)1, 2 Jin L....Rape M. (2008)
    3. Localization of the coactivator Cdh1 and the cullin subunit Apc2 in a cryo-electron microscopy model of vertebrate APC/C. (PubMed id 16364912)1, 2 Dube P.... Stark H. (2005)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    6. Mitotic regulation of the human anaphase-promoting complex by phosphorylation. (PubMed id 14657031)1, 2 Kraft C....Peters J.-M. (2003)
    7. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
    8. Charting the landscape of tandem BRCT domain-mediated protein interactions. (PubMed id 22990118)1 Woods N.T....Monteiro A.N. (2012)
    9. ANAPC1 and SLCO3A1 are associated with nicotine depend ence: meta-analysis of genome-wide association studies. (PubMed id 22377092)1 Wang K.S....Zeng M. (2012)
    10. Global landscape of HIV-human protein complexes. (PubMed id 22190034)1 Jager S....Krogan N.J. (2012)

    External Searches for ANAPC1 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing ANAPC1 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 64682 HGNC: 19988 AceView: ANAPC1 Ensembl:ENSG00000153107 euGenes: HUgn64682
    ECgene: ANAPC1 Kegg: 64682 H-InvDB: ANAPC1

    Other Databases showing ANAPC1 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing ANAPC1 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ANAPC1 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for ANAPC1 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for ANAPC1 gene:
    Search GeneIP for patents involving ANAPC1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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