Free for academic non-profit institutions. Other users need a Commercial license

Aliases for ANAPC1 Gene

Aliases for ANAPC1 Gene

  • Anaphase Promoting Complex Subunit 1 2 3
  • Testis-Specific Gene 24 Protein 3 4
  • Mitotic Checkpoint Regulator 3 4
  • Cyclosome Subunit 1 3 4
  • TSG24 3 4
  • APC1 3 4
  • Anaphase-Promoting Complex 1 (Meiotic Checkpoint Regulator) 3
  • MCPR 3

External Ids for ANAPC1 Gene

Previous GeneCards Identifiers for ANAPC1 Gene

  • GC02M110445
  • GC02M112430
  • GC02M112621
  • GC02M112242
  • GC02M087019
  • GC02M112523

Summaries for ANAPC1 Gene

Entrez Gene Summary for ANAPC1 Gene

  • This gene encodes a subunit of the anaphase-promoting complex. This complex is an E3 ubiquitin ligase that regulates progression through the metaphase to anaphase portion of the cell cycle by ubiquitinating proteins which targets them for degradation. [provided by RefSeq, Dec 2011]

GeneCards Summary for ANAPC1 Gene

ANAPC1 (Anaphase Promoting Complex Subunit 1) is a Protein Coding gene. Among its related pathways are Immune System and Activation of cAMP-Dependent PKA.

UniProtKB/Swiss-Prot for ANAPC1 Gene

  • Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of Lys-11-linked polyubiquitin chains and, to a lower extent, the formation of Lys-48- and Lys-63-linked polyubiquitin chains.

Gene Wiki entry for ANAPC1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ANAPC1 Gene

Genomics for ANAPC1 Gene

Regulatory Elements for ANAPC1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for ANAPC1 Gene

Chromosome:
2
Start:
111,766,271 bp from pter
End:
111,884,690 bp from pter
Size:
118,420 bases
Orientation:
Minus strand

Genomic View for ANAPC1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ANAPC1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ANAPC1 Gene

Proteins for ANAPC1 Gene

  • Protein details for ANAPC1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H1A4-APC1_HUMAN
    Recommended name:
    Anaphase-promoting complex subunit 1
    Protein Accession:
    Q9H1A4
    Secondary Accessions:
    • Q2M3H8
    • Q9BSE6
    • Q9H8D0

    Protein attributes for ANAPC1 Gene

    Size:
    1944 amino acids
    Molecular mass:
    216500 Da
    Quaternary structure:
    • The mammalian APC/C is composed of 14 distinct subunits that assemble into a complex of at least 19 chains with a combined molecular mass of around 1.2 MDa.

    Three dimensional structures from OCA and Proteopedia for ANAPC1 Gene

neXtProt entry for ANAPC1 Gene

Proteomics data for ANAPC1 Gene at MOPED

Post-translational modifications for ANAPC1 Gene

  • Phosphorylated. Phosphorylation on Ser-355 occurs specifically during mitosis.
  • Ubiquitination at Lys 310, Lys 695, Lys 905, Lys 985, and Lys 1066
  • Modification sites at PhosphoSitePlus

Other Protein References for ANAPC1 Gene

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for ANAPC1 (APC1)

No data available for DME Specific Peptides for ANAPC1 Gene

Domains & Families for ANAPC1 Gene

Gene Families for ANAPC1 Gene

Protein Domains for ANAPC1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for ANAPC1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9H1A4

UniProtKB/Swiss-Prot:

APC1_HUMAN :
  • Belongs to the APC1 family.
  • Contains 4 PC repeats.
Family:
  • Belongs to the APC1 family.
Similarity:
  • Contains 4 PC repeats.
genes like me logo Genes that share domains with ANAPC1: view

Function for ANAPC1 Gene

Molecular function for ANAPC1 Gene

UniProtKB/Swiss-Prot Function:
Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of Lys-11-linked polyubiquitin chains and, to a lower extent, the formation of Lys-48- and Lys-63-linked polyubiquitin chains.

Gene Ontology (GO) - Molecular Function for ANAPC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with ANAPC1: view
genes like me logo Genes that share phenotypes with ANAPC1: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for ANAPC1 Gene

Localization for ANAPC1 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ANAPC1 Gene COMPARTMENTS Subcellular localization image for ANAPC1 gene
Compartment Confidence
nucleus 5
cytosol 4

Gene Ontology (GO) - Cellular Components for ANAPC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus --
GO:0005654 nucleoplasm TAS --
GO:0005680 anaphase-promoting complex IDA 16364912
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with ANAPC1: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for ANAPC1 Gene

Pathways & Interactions for ANAPC1 Gene

SuperPathways for ANAPC1 Gene

Superpath Contained pathways
1 CDK-mediated phosphorylation and removal of Cdc6
2 Separation of Sister Chromatids
3 APC-Cdc20 mediated degradation of Nek2A
4 Cell Cycle, Mitotic
.62
5 Cellular Senescence
genes like me logo Genes that share pathways with ANAPC1: view

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

UniProtKB/Swiss-Prot Q9H1A4-APC1_HUMAN

  • Pathway: Protein modification; protein ubiquitination

SIGNOR curated interactions for ANAPC1 Gene

Is activated by:

Gene Ontology (GO) - Biological Process for ANAPC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000278 mitotic cell cycle TAS --
GO:0007067 mitotic nuclear division IEA --
GO:0007094 mitotic spindle assembly checkpoint TAS --
GO:0031145 anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process TAS --
GO:0051301 cell division IEA --
genes like me logo Genes that share ontologies with ANAPC1: view

Drugs & Compounds for ANAPC1 Gene

No Compound Related Data Available

Transcripts for ANAPC1 Gene

Unigene Clusters for ANAPC1 Gene

Anaphase promoting complex subunit 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ANAPC1 Gene

No ASD Table

Relevant External Links for ANAPC1 Gene

GeneLoc Exon Structure for
ANAPC1
ECgene alternative splicing isoforms for
ANAPC1

Expression for ANAPC1 Gene

mRNA expression in normal human tissues for ANAPC1 Gene

Protein differential expression in normal tissues from HIPED for ANAPC1 Gene

This gene is overexpressed in Breast (24.6), Lung (15.2), and Cerebrospinal fluid (6.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for ANAPC1 Gene



SOURCE GeneReport for Unigene cluster for ANAPC1 Gene Hs.436527

genes like me logo Genes that share expression patterns with ANAPC1: view

Protein tissue co-expression partners for ANAPC1 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for ANAPC1 Gene

Orthologs for ANAPC1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for ANAPC1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia ANAPC1 35
  • 90.05 (n)
  • 95.57 (a)
ANAPC1 36
  • 95 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ANAPC1 35
  • 93.4 (n)
  • 97.43 (a)
ANAPC1 36
  • 96 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Anapc1 35
  • 87.93 (n)
  • 92.39 (a)
Anapc1 16
Anapc1 36
  • 92 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Anapc1 35
  • 87.96 (n)
  • 92.95 (a)
oppossum
(Monodelphis domestica)
Mammalia ANAPC1 36
  • 90 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 87 (a)
OneToMany
-- 36
  • 95 (a)
OneToMany
-- 36
  • 80 (a)
OneToMany
-- 36
  • 83 (a)
OneToMany
-- 36
  • 77 (a)
OneToMany
-- 36
  • 84 (a)
OneToMany
chimpanzee
(Pan troglodytes)
Mammalia ANAPC1 36
  • 100 (a)
OneToOne
chicken
(Gallus gallus)
Aves ANAPC1 35
  • 76.53 (n)
  • 81.9 (a)
ANAPC1 36
  • 81 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ANAPC1 36
  • 84 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia anapc1 35
  • 73.59 (n)
  • 80.81 (a)
Str.16338 35
zebrafish
(Danio rerio)
Actinopterygii anapc1 35
  • 65.73 (n)
  • 68.41 (a)
anapc1 36
  • 67 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP000374 35
  • 43.77 (n)
  • 36 (a)
fruit fly
(Drosophila melanogaster)
Insecta shtd 35
  • 46.97 (n)
  • 39.07 (a)
shtd 36
  • 29 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea mat-2 36
  • 19 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes APC1 36
  • 19 (a)
OneToOne
APC1 38
thale cress
(Arabidopsis thaliana)
eudicotyledons EMB2771 35
  • 45.78 (n)
  • 35.82 (a)
rice
(Oryza sativa)
Liliopsida Os05g0354300 35
  • 49.44 (n)
  • 39.64 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 32 (a)
OneToOne
Species with no ortholog for ANAPC1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ANAPC1 Gene

ENSEMBL:
Gene Tree for ANAPC1 (if available)
TreeFam:
Gene Tree for ANAPC1 (if available)

Paralogs for ANAPC1 Gene

genes like me logo Genes that share paralogs with ANAPC1: view

No data available for Paralogs for ANAPC1 Gene

Variants for ANAPC1 Gene

Sequence variations from dbSNP and Humsavar for ANAPC1 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs13006560 -- 111,880,784(+) TCCCT(G/T)GCTGC reference, synonymous-codon, utr-variant-5-prime, upstream-variant-2KB
rs13009182 -- 111,838,743(+) ggGCT(C/T)CTAAG intron-variant
rs13010283 -- 111,839,196(+) aaaga(C/T)aaaag intron-variant
rs13011167 -- 111,863,768(+) AATTC(C/T)GGAAA reference, missense
rs13011359 -- 111,863,849(+) CATTC(C/T)GTGGG reference, missense

Structural Variations from Database of Genomic Variants (DGV) for ANAPC1 Gene

Variant ID Type Subtype PubMed ID
nsv521956 CNV Loss 19592680
nsv428402 CNV Loss 18775914
dgv1236e1 CNV Complex 17122850
dgv1237e1 CNV Complex 17122850
dgv1238e1 CNV Complex 17122850
esv27292 CNV Gain+Loss 19812545
dgv4277n71 CNV Gain 21882294
nsv10127 CNV Gain 18304495
nsv874860 CNV Gain 21882294
nsv834333 CNV Gain 17160897
nsv874862 CNV Loss 21882294
nsv215083 CNV Loss 16902084
nsv514974 CNV Complex 21397061
nsv874863 CNV Loss 21882294
esv26491 CNV Gain 19812545
dgv4278n71 CNV Gain 21882294

Variation tolerance for ANAPC1 Gene

Residual Variation Intolerance Score: 77.45% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.05; 50.48% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ANAPC1 Gene

HapMap Linkage Disequilibrium report
ANAPC1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ANAPC1 Gene

Disorders for ANAPC1 Gene

Relevant External Links for ANAPC1

Human Genome Epidemiology (HuGE) Navigator
ANAPC1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ANAPC1
genes like me logo Genes that share disorders with ANAPC1: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ANAPC1 Gene

Publications for ANAPC1 Gene

  1. Characterisation of the human APC1, the largest subunit of the anaphase-promoting complex. (PMID: 11179667) Joergensen P.M. … Hoeoeg C. (Gene 2001) 2 23 67
  2. Modulations of cell cycle checkpoints during HCV associated disease. (PMID: 19664251) Sarfraz S. … Siddiqui A.A. (BMC Infect. Dis. 2009) 23 67
  3. Mutation analysis of p31comet gene, a negative regulator of Mad2, in human hepatocellular carcinoma. (PMID: 17934339) Yun M.Y. … Lee K.H. (Exp. Mol. Med. 2007) 23 67
  4. Mutation of the Apc1 homologue shattered disrupts normal eye development by disrupting G1 cell cycle arrest and progression through mitosis. (PMID: 17689521) Tanaka-Matakatsu M. … Du W. (Dev. Biol. 2007) 23 67
  5. Epigenetic inactivation of CHFR in nasopharyngeal carcinoma through promoter methylation. (PMID: 15937956) Cheung H.W. … Wang X. (Mol. Carcinog. 2005) 23 67

Products for ANAPC1 Gene

Sources for ANAPC1 Gene

Back to Top

Content