Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



AMZ2 Gene

protein-coding   GIFtS: 52
GCID: GC17P066244

Archaelysin Family Metallopeptidase 2

  Try our

disease database 

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Archaelysin Family Metallopeptidase 21 2
archaemetzincin-21 2
Archeobacterial Metalloproteinase-Like Protein 22 3
archaemetzincins-22
EC 3.4.-.-3

External Ids:    HGNC: 280411   Entrez Gene: 513212   Ensembl: ENSG000001967047   OMIM: 6151695   UniProtKB: Q86W343   
ORGUL members:         

Export aliases for AMZ2 gene to outside databases

Previous GC identifers: GC17P063756 GC17P061630


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

GeneCards Summary for AMZ2 Gene:
AMZ2 (archaelysin family metallopeptidase 2) is a protein-coding gene. GO annotations related to this gene include metallopeptidase activity. An important paralog of this gene is AMZ1.

UniProtKB/Swiss-Prot: AMZ2_HUMAN, Q86W34
Function: Zinc metalloprotease. Exhibits activity against angiotensin-3 in vitro. Does not hydrolyze either
neurogranin or angiotensin-2




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence at NCBI GenBank:
NC_000017.10  NT_010783.16  NC_018928.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the AMZ2 gene promoter:
         c-Fos   SRF   AP-1   ATF-2   SRF (504 AA)   NF-E2 p45   RORalpha2   AREB6   RORalpha1   NF-E2   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for AMZ2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat AMZ2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q24.2   Ensembl cytogenetic band:  17q24.2   HGNC cytogenetic band: 17q24.2

AMZ2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
AMZ2 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17P066244:  view genomic region     (about GC identifiers)

Start:
66,243,715 bp from pter      End:
66,253,305 bp from pter
Size:
9,591 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: AMZ2_HUMAN, Q86W34 (See protein sequence)
Recommended Name: Archaemetzincin-2  
Size: 360 amino acids; 41263 Da
Cofactor: Binds 2 zinc ions per subunit. One is catalytic, whereas the other seems to have a structural role (By
similarity)
Sequence caution: Sequence=AAF64270.1; Type=Erroneous termination; Positions=98; Note=Translated as Gly;
Sequence=AAF64270.1; Type=Frameshift; Positions=55;
Secondary accessions: A6NLD9 B3KR44 Q5XKF1 Q9NZE2
Alternative splicing: 2 isoforms:  Q86W34-4   Q86W34-5   (Gene prediction based on EST data)

Explore the universe of human proteins at neXtProt for AMZ2: NX_Q86W34

Explore proteomics data for AMZ2 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See AMZ2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (8 alternative transcripts): 
    NP_001028741.1  NP_001028742.1  NP_001028743.1  NP_001028744.1  NP_001028746.1  NP_001275983.1  NP_001275985.1  NP_057711.3  

    ENSEMBL proteins: 
     ENSP00000352976   ENSP00000462484   ENSP00000463012   ENSP00000376481   ENSP00000352831  
     ENSP00000463053   ENSP00000463596   ENSP00000461935   ENSP00000462292   ENSP00000464133  
     ENSP00000464635   ENSP00000462140   ENSP00000463344   ENSP00000463857  

    AMZ2 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for AMZ2
    OriGene Custom MassSpec
    OriGene Custom Protein Services for AMZ2
    GenScript Custom Purified and Recombinant Proteins Services for AMZ2
    Novus Biologicals AMZ2 Protein
    Novus Biologicals AMZ2 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for AMZ2

     
    Search eBioscience for Proteins for AMZ2 

    AMZ2 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for AMZ2
    Novus Biologicals AMZ2 Antibodies
    Abcam antibodies for AMZ2
    Cloud-Clone Corp. Antibodies for AMZ2
    Search ThermoFisher Antibodies for AMZ2
    LSBio Antibodies in human, mouse, rat for AMZ2

    AMZ2 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for AMZ2
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for AMZ2
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for AMZ2
    Cloud-Clone Corp. CLIAs for AMZ2
    Search eBioscience for ELISAs for AMZ2 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    2 InterPro protein domains:
     IPR024079 MetalloPept_cat_dom
     IPR012962 Pept_M54_archaemetzincn

    Graphical View of Domain Structure for InterPro Entry Q86W34

    ProtoNet protein and cluster: Q86W34

    1 Blocks protein domain: IPB012962 Peptidase predicted

    UniProtKB/Swiss-Prot: AMZ2_HUMAN, Q86W34
    Similarity: Belongs to the peptidase M54 family


    Find genes that share domains with AMZ2           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: AMZ2_HUMAN, Q86W34
    Function: Zinc metalloprotease. Exhibits activity against angiotensin-3 in vitro. Does not hydrolyze either
    neurogranin or angiotensin-2
    Enzyme regulation: Inhibited by the general metalloprotease inhibitors o-phenanthroline and batimastat. Also
    significantly inhibited by amastatin, which is an inhibitor of aminopeptidases. Not inhibited by
    4-(2-aminoethyl)-benzenesulfonyl fluoride, E-64, and TIMPS (tissue inhibitors of metalloproteinases), which are
    inhibitors of serine, cysteine, and matrix metalloproteases, respectively
    Biophysicochemical properties: pH dependence: Optimum pH is 7.0;

         Enzyme Number (IUBMB): EC 3.4.-.-1

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008237metallopeptidase activity IEA--
    GO:0008270zinc ion binding IEA--
         
    Find genes that share ontologies with AMZ2           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for AMZ2:
     Increased Salmonella enterica  

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for AMZ2
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for AMZ2

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for AMZ2
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for AMZ2

    miRNA
    Products:
        
    miRTarBase miRNAs that target AMZ2:
    hsa-mir-421 (MIRT039424)

    Block miRNA regulation of human, mouse, rat AMZ2 using miScript Target Protectors
    1 qRT-PCR Assays for microRNA that regulate AMZ2:
    hsa-miR-493
    SwitchGear 3'UTR luciferase reporter plasmidAMZ2 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for AMZ2
    Predesigned siRNA for gene silencing in human, mouse, rat AMZ2

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for AMZ2

    Clone
    Products:
         
    OriGene clones in human, mouse for AMZ2 (see all 32)
    OriGene ORF clones in mouse, rat for AMZ2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 6): AMZ2 (NM_001033569)
    Sino Biological Human cDNA Clone for AMZ2
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for AMZ2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat AMZ2

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for AMZ2
    Browse ESI BIO Cell Lines and PureStem Progenitors for AMZ2 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for AMZ2


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol3
    nucleus2
    peroxisome1

    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus




        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for AMZ2
    Interactions:

        Search GeneGlobe Interaction Network for AMZ2

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    1 Interacting protein for AMZ2 (ENSP000003529764) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    UBCENSP000003448184STRING: ENSP00000344818
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006508proteolysis ----

    Find genes that share ontologies with AMZ2           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for AMZ2



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for AMZ2 gene (8 alternative transcripts): 
    NM_001033569.1  NM_001033570.1  NM_001033571.1  NM_001033572.1  NM_001033574.1  NM_001289054.1  NM_001289056.1  NM_016627.4  

    Unigene Cluster for AMZ2:

    Archaelysin family metallopeptidase 2
    Hs.293560  [show with all ESTs]
    Unigene Representative Sequence: AK126146
    18 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000359904(uc002jgt.1 uc002jgs.1 uc002jgr.1 uc002jgu.1 uc002jgv.1 uc002jgw.1)
    ENST00000580548 ENST00000580753 ENST00000392720 ENST00000359783 ENST00000584837
    ENST00000578175 ENST00000579724 ENST00000584494 ENST00000580837(uc002jgx.1)
    ENST00000577866 ENST00000585050 ENST00000582430 ENST00000577985(uc002jgy.1)
    ENST00000577273 ENST00000584836 ENST00000584350 ENST00000581779
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat AMZ2 using miScript Target Protectors
    1 qRT-PCR Assays for microRNA that regulate AMZ2:
    hsa-miR-493
    SwitchGear 3'UTR luciferase reporter plasmidAMZ2 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for AMZ2
    Predesigned siRNA for gene silencing in human, mouse, rat AMZ2
    Clone
    Products:
         
    OriGene clones in human, mouse for AMZ2 (see all 32)
    OriGene ORF clones in mouse, rat for AMZ2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 6): AMZ2 (NM_001033569)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for AMZ2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat AMZ2
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for AMZ2
    OriGene qSTAR qPCR primer pairs in human, mouse for AMZ2
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat AMZ2
      QuantiTect SYBR Green Assays in human, mouse, rat AMZ2
      QuantiFast Probe-based Assays in human, mouse, rat AMZ2

    Additional mRNA sequence: 

    AJ635358.1 AK126146.1 BC035935.2 BC050709.1 BC056271.1 

    14 DOTS entries:

    DT.100855970  DT.97784726  DT.101964271  DT.100651593  DT.100651597  DT.95374651  DT.92455021  DT.451120 
    DT.95374656  DT.120934661  DT.100651595  DT.105583  DT.75103657  DT.91959679 

    Selected AceView cDNA sequences (see all 377):

    BU686939 BU686221 BQ446613 CR600562 AA668710 CR596257 AI147856 AI143369 
    BG028543 BQ688066 CD517833 AL526271 AI201423 BF055528 BM978527 CR609550 
    AW572515 AA771971 BU782510 BC050709 BQ877843 CR603455 AI499729 CR598159 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for AMZ2 (see all 10)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c ^ 3a · 3b · 3c ^ 4 ^ 5a · 5b · 5c · 5d · 5e ^ 6a · 6b · 6c · 6d · 6e ^ 7 ^ 8a · 8b ^ 9 ^ 10
    SP1:                                      -     -           -                             -                                                               
    SP2:                                                                                                                                                      
    SP3:                    -     -     -     -     -           -                             -                                                               
    SP4:                    -     -     -     -     -           -                             -                                                               
    SP5:                                -     -     -           -                             -                                                               


    ECgene alternative splicing isoforms for AMZ2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    AMZ2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTATGCTTTC
    AMZ2 Expression
    About this image


    AMZ2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     
     Eye (Sensory Organs)
             Retina
    AMZ2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    AMZ2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.293560

    UniProtKB/Swiss-Prot: AMZ2_HUMAN, Q86W34
    Tissue specificity: Predominantly expressed in heart and testis. Also expressed at lower levels in kidney, liver,
    pancreas, lung, brain and placenta. Expressed in fetal tissues such as kidney, liver, lung and brain.
    Down-regulated in testis from patients with maturation arrest (MA) or Sertoli cell-only syndrome (SCOS)

        Custom PCR Arrays for AMZ2
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for AMZ2
    OriGene qSTAR qPCR primer pairs in human, mouse for AMZ2
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat AMZ2
    QuantiTect SYBR Green Assays in human, mouse, rat AMZ2
    QuantiFast Probe-based Assays in human, mouse, rat AMZ2
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for AMZ2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of chordates.

    Orthologs for AMZ2 gene from Selected species (see all 9)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Amz21 , 5 archaelysin family metallopeptidase 21, 5 81.62(n)1
    79.39(a)1
      11 (71.89 cM)5
    139291  NM_001252193.11  NP_001239122.11 
     1094259765 
    lizard
    (Anolis carolinensis)
    Reptilia AMZ26
    archaelysin family metallopeptidase 2
    67(a)
    1 ↔ 1
    GL343260.1(1445104-1454505)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia LOC1004947741 archaemetzincin-2-like 62.86(n)
    59.78(a)
      100494774  XM_002940629.2  XP_002940675.2 
    zebrafish
    (Danio rerio)
    Actinopterygii AMZ2 (2 of 2)6
    AMZ2 (1 of 2)6
    archaelysin family metallopeptidase 2
    51(a)
    41(a)
    1 ↔ many
    1 ↔ many
    12(21904151-21907037) ENSDARG00000089810
    12(21909237-21913265) ENSDARG00000089248


    ENSEMBL Gene Tree for AMZ2 (if available)
    TreeFam Gene Tree for AMZ2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for AMZ2 gene
    AMZ12  
    2 SIMAP similar genes for AMZ2 using alignment to 9 protein entries:     AMZ2_HUMAN (see all proteins):
    KIAA1950    AMZ1

    Find genes that share paralogs with AMZ2           About GenesLikeMe


    4 Pseudogenes.org Pseudogenes for AMZ2
    PGOHUM00000262965 PGOHUM00000263098 PGOHUM00000243433 PGOHUM00000241216


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for AMZ2 (see all 291)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1458539081,2
    --66242171(+) GTGGGA/GCGCGG 6 -- us2k10--------
    rs72198711,2
    C,F--66242335(+) aaaatC/Acaaaa 6 -- us2k12Minor allele frequency- A:0.50NA 4
    rs711421571,2
    C--66242337(-) TTTTT-/TTTTTT 6 -- us2k11Minor allele frequency- T:0.00NA 2
    rs37602731,2
    C,F--66242378(-) GCACAC/TACCAC 6 -- us2k12Minor allele frequency- T:0.50NA 4
    rs1914615001,2
    --66242441(+) GAAGCA/GTAAGT 6 -- us2k10--------
    rs37602721,2
    C,F--66242442(-) AACTTA/CTGCTT 6 -- us2k16Minor allele frequency- C:0.19NA WA CSA EA 247
    rs37602711,2
    C,F,A--66242481(-) TCCAGG/ACTGGA 6 -- us2k18Minor allele frequency- A:0.43NA WA CSA 14
    rs1473417571,2
    --66242495(+) CAGAGC/TGAGAC 6 -- us2k10--------
    rs37602701,2
    C,F--66242568(-) AACTAC/TTTGAC 6 -- us2k15Minor allele frequency- T:0.09WA CSA NA EA 362
    rs1823550711,2
    --66242569(+) TCAAGC/TAGTTG 6 -- us2k10--------

    HapMap Linkage Disequilibrium report for AMZ2 (66243715 - 66253305 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for AMZ2:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2716144CNV Deletion23290073
    esv2716143CNV Deletion23290073
    esv2716146CNV Deletion23290073
    esv2716145CNV Deletion23290073

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing AMZ2
    DNA2.0 Custom Variant and Variant Library Synthesis for AMZ2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 615169    OMIM disorders: --


    Find genes that share disorders with AMZ2           About GenesLikeMe

    Genetic Association Database (GAD): AMZ2
    Human Genome Epidemiology (HuGE) Navigator: AMZ2 (1 document)

    Export disorders for AMZ2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for AMZ2 gene, integrated from 10 sources (see all 13):
    (articles sorted by number of sources associating them with AMZ2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification and characterization of human archaemetzincin-1 and - 2, two novel members of a family of metalloproteases widely distributed in Archaea. (PubMed id 15972818)1, 2, 3, 9 Diaz-Perales A.... Lopez-Otin C. (J. Biol. Chem. 2005)
    2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    5. Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. (PubMed id 11042152)1, 2 Zhang Q.-H.... Chen Z. (Genome Res. 2000)
    6. Pathway Analysis of ChIP-Seq-Based NRF1 Target Genes Suggests a Logical Hypothesis of their Involvement in the Pathogenesis of Neurodegenerative Diseases. (PubMed id 24250222)1 Satoh J....Yamamoto Y. (Gene Regul Syst Bio 2013)
    7. Systematic and quantitative assessment of the ubiquitin-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (Mol. Cell 2011)
    8. Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (amp 2011)
    9. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965)1 Lamesch P.... Vidal M. (Genomics 2007)
    10. Identification of ten novel genes involved in human spermatogenesis by microarray analysis of testicular tissue. (PubMed id 17074343)2 Lin Y.H.... Kuo P.L. (Fertil. Steril. 2006)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 51321 HGNC: 28041 AceView: LOC51321 Ensembl:ENSG00000196704 euGenes: HUgn51321
    ECgene: AMZ2 H-InvDB: AMZ2

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for AMZ2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for AMZ2 gene:
    Search GeneIP for patents involving AMZ2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for AMZ2  
     OriGene qPCR primer pairs and template standards for AMZ2   OriGene Protein Over-expression Lysate for AMZ2  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for AMZ2  
     OriGene qSTAR qPCR primer pairs in human, mouse for AMZ2   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for AMZ2   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for AMZ2   OriGene Custom Protein Services for AMZ2  

     
     
     Block miRNA regulation of human, mouse, rat AMZ2 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing AMZ2
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat AMZ2 Predesigned siRNA for gene silencing in human, mouse, rat AMZ2
     QuantiFast Probe-based Assays in human, mouse, rat AMZ2 QuantiTect SYBR Green Assays in human, mouse, rat AMZ2
     Custom PCR Arrays for AMZ2 Search Chromatin IP Primers for AMZ2
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat AMZ2  Search GeneGlobe Interaction Network for AMZ2
     Regulatory tfbs in AMZ2 promoter
     GenScript Custom Purified and Recombinant Proteins Services for AMZ2 GenScript cDNA clones with any tag delivered in your preferred vector for AMZ2
     GenScript Custom Assay Services for AMZ2 GenScript Custom overexpressing Cell Line Services for AMZ2
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for AMZ2
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     cDNA Clones for AMZ2
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     AMZ2 antibodies
     AMZ2 proteins
     AMZ2 lysates
     Antibodies for AMZ2
     See all of Abcam's Antibodies, Kits and Proteins for AMZ2
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Proteins for AMZ2
     Antibodies for AMZ2
     ELISAs for AMZ2
     CLIAs for AMZ2



     Browse ESI BIO Cell Lines and PureStem Progenitors for AMZ2
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for AMZ2
     SwitchGear 3'UTR luciferase reporter plasmids for AMZ2
     Browse SwitchGear Promoter luciferase reporter plasmids for AMZ2
     Search ThermoFisher Antibodies for AMZ2
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat AMZ2
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for AMZ2
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for AMZ2
     LSBio Antibodies in human, mouse, rat for AMZ2
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
     Search Addgene for plasmids for AMZ2
      Search eBioscience for proteins for AMZ2
      Search eBioscience for elisas for AMZ2
      eBioscience FlowRNA Probe Sets
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      AMZ2 gene at Home site.
    Version: 3.12.224 13 Oct 2014
    hostname: 356980-web2.xennexinc.com index build: 128 solr: 1.4