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Aliases for AMZ2 Gene

Aliases for AMZ2 Gene

  • Archaelysin Family Metallopeptidase 2 2 3 5
  • Archeobacterial Metalloproteinase-Like Protein 2 3 4
  • Archaemetzincin-2 2 3
  • Archaemetzincins-2 3
  • EC 3.4.-.- 4

External Ids for AMZ2 Gene

Previous GeneCards Identifiers for AMZ2 Gene

  • GC17P063756
  • GC17P066244
  • GC17P061630
  • GC17P068206

Summaries for AMZ2 Gene

Entrez Gene Summary for AMZ2 Gene

  • The protein encoded by this gene is a zinc metalloprotease that displays some activity against angiotensin-3. The encoded protein is inhibited by the aminopeptidase inhibitor amastatin, as well as by the general inhibitors o-phenanthroline and batimastat. Defects in this gene may be associated with lung tumorigenesis. [provided by RefSeq, Oct 2016]

GeneCards Summary for AMZ2 Gene

AMZ2 (Archaelysin Family Metallopeptidase 2) is a Protein Coding gene. GO annotations related to this gene include metallopeptidase activity. An important paralog of this gene is AMZ1.

UniProtKB/Swiss-Prot for AMZ2 Gene

  • Zinc metalloprotease. Exhibits activity against angiotensin-3 in vitro. Does not hydrolyze either neurogranin or angiotensin-2.

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for AMZ2 Gene

Genomics for AMZ2 Gene

Regulatory Elements for AMZ2 Gene

Enhancers for AMZ2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH17G068252 1.9 FANTOM5 Ensembl ENCODE dbSUPER 22.7 +50.7 50737 8.7 HDGF PKNOX1 FOXA2 SIN3A TCF12 ZNF121 GATA2 ELK1 ZNF143 ZNF207 AMZ2 ARSG WIPI1 MIR635 BPTF ENSG00000265100
GH17G068246 1.4 ENCODE dbSUPER 24.7 +42.7 42668 3.8 HDGF HNRNPUL1 PKNOX1 CREB3L1 ZFP64 ARID4B SIN3A FEZF1 DMAP1 ZNF2 AMZ2 WIPI1 ENSG00000267731 ENSG00000265100 ARSG
GH17G068262 1.2 Ensembl ENCODE dbSUPER 23.4 +57.3 57304 1.0 CTCF TFAP4 ZNF654 HLF TRIM22 ZFP37 MNT ZNF48 RAD21 ZNF579 AMZ2 ARSG WIPI1 MIR635 GC17P068267
GH17G068304 1.8 FANTOM5 Ensembl ENCODE dbSUPER 11.3 +99.4 99380 1.4 HDGF ATF1 SIN3A GLI4 DMAP1 ZNF48 ZNF2 ZBTB7B YY1 ZNF766 AMZ2 ARSG MIR635 SLC16A6 BPTF GC17M068333
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around AMZ2 on UCSC Golden Path with GeneCards custom track

Promoters for AMZ2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000097470 103 2601 MLX AGO1 DMAP1 YBX1 YY1 SLC30A9 ZNF143 ZNF263 MCM3 SP3

Genomic Location for AMZ2 Gene

68,205,997 bp from pter
68,257,164 bp from pter
51,168 bases
Plus strand

Genomic View for AMZ2 Gene

Genes around AMZ2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
AMZ2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for AMZ2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for AMZ2 Gene

Proteins for AMZ2 Gene

  • Protein details for AMZ2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein Accession:
    Secondary Accessions:
    • A6NLD9
    • B3KR44
    • Q5XKF1
    • Q9NZE2

    Protein attributes for AMZ2 Gene

    360 amino acids
    Molecular mass:
    41263 Da
    Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
    Quaternary structure:
    No Data Available
    • Sequence=AAF64270.1; Type=Erroneous termination; Positions=98; Note=Translated as Gly.; Evidence={ECO:0000305}; Sequence=AAF64270.1; Type=Frameshift; Positions=55; Evidence={ECO:0000305};

    Alternative splice isoforms for AMZ2 Gene


neXtProt entry for AMZ2 Gene

Post-translational modifications for AMZ2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for AMZ2 Gene

Domains & Families for AMZ2 Gene

Protein Domains for AMZ2 Gene

Suggested Antigen Peptide Sequences for AMZ2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the peptidase M54 family.
  • Belongs to the peptidase M54 family.
genes like me logo Genes that share domains with AMZ2: view

No data available for Gene Families for AMZ2 Gene

Function for AMZ2 Gene

Molecular function for AMZ2 Gene

UniProtKB/Swiss-Prot BiophysicochemicalProperties:
pH dependence: Optimum pH is 7.0. {ECO:0000269 PubMed:15972818};
UniProtKB/Swiss-Prot EnzymeRegulation:
Inhibited by the general metalloprotease inhibitors o-phenanthroline and batimastat. Also significantly inhibited by amastatin, which is an inhibitor of aminopeptidases. Not inhibited by 4-(2-aminoethyl)-benzenesulfonyl fluoride, E-64, and TIMPS (tissue inhibitors of metalloproteinases), which are inhibitors of serine, cysteine, and matrix metalloproteases, respectively.
UniProtKB/Swiss-Prot Function:
Zinc metalloprotease. Exhibits activity against angiotensin-3 in vitro. Does not hydrolyze either neurogranin or angiotensin-2.

Enzyme Numbers (IUBMB) for AMZ2 Gene

Gene Ontology (GO) - Molecular Function for AMZ2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008233 peptidase activity IEA --
GO:0008237 metallopeptidase activity IEA --
GO:0008270 zinc ion binding IEA --
GO:0016787 hydrolase activity IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with AMZ2: view
genes like me logo Genes that share phenotypes with AMZ2: view

Animal Model Products

CRISPR Products

miRNA for AMZ2 Gene

miRTarBase miRNAs that target AMZ2

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for AMZ2

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for AMZ2 Gene

Localization for AMZ2 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for AMZ2 gene
Compartment Confidence
nucleus 3
cytosol 3
peroxisome 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for AMZ2 Gene

Pathways & Interactions for AMZ2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for AMZ2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006508 proteolysis IEA --
genes like me logo Genes that share ontologies with AMZ2: view

No data available for Pathways by source and SIGNOR curated interactions for AMZ2 Gene

Drugs & Compounds for AMZ2 Gene

No Compound Related Data Available

Transcripts for AMZ2 Gene

Unigene Clusters for AMZ2 Gene

Archaelysin family metallopeptidase 2:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for AMZ2

Alternative Splicing Database (ASD) splice patterns (SP) for AMZ2 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c ^ 3a · 3b · 3c ^ 4 ^ 5a · 5b · 5c · 5d · 5e ^ 6a · 6b · 6c · 6d · 6e ^ 7 ^ 8a · 8b ^ 9 ^ 10
SP1: - - - -
SP3: - - - - - - -
SP4: - - - - - - -
SP5: - - - - -
SP6: - - -
SP7: - -
SP9: -
SP10: - - - - - -

Relevant External Links for AMZ2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for AMZ2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for AMZ2 Gene

Protein differential expression in normal tissues from HIPED for AMZ2 Gene

This gene is overexpressed in Testis (31.1), Ovary (14.6), and Fetal Brain (10.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for AMZ2 Gene

NURSA nuclear receptor signaling pathways regulating expression of AMZ2 Gene:


SOURCE GeneReport for Unigene cluster for AMZ2 Gene:


mRNA Expression by UniProt/SwissProt for AMZ2 Gene:

Tissue specificity: Predominantly expressed in heart and testis. Also expressed at lower levels in kidney, liver, pancreas, lung, brain and placenta. Expressed in fetal tissues such as kidney, liver, lung and brain. Down-regulated in testis from patients with maturation arrest (MA) or Sertoli cell-only syndrome (SCOS).

Evidence on tissue expression from TISSUES for AMZ2 Gene

  • Nervous system(4.9)
  • Bone marrow(4.3)
  • Lung(4.3)
  • Blood(4.2)
  • Skin(2.5)
genes like me logo Genes that share expression patterns with AMZ2: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for AMZ2 Gene

Orthologs for AMZ2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for AMZ2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia AMZ2 35
  • 98 (a)
(Canis familiaris)
Mammalia AMZ2 34 35
  • 88.89 (n)
(Mus musculus)
Mammalia Amz2 34 35
  • 81.62 (n)
(Bos Taurus)
Mammalia AMZ2 34 35
  • 80.51 (n)
(Rattus norvegicus)
Mammalia Amz2 34
  • 79.67 (n)
(Ornithorhynchus anatinus)
Mammalia AMZ2 35
  • 58 (a)
(Anolis carolinensis)
Reptilia AMZ2 35
  • 67 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100494774 34
  • 62.86 (n)
(Danio rerio)
Actinopterygii AMZ2 (2 of 2) 35
  • 51 (a)
AMZ2 (1 of 2) 35
  • 41 (a)
Species where no ortholog for AMZ2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for AMZ2 Gene

Gene Tree for AMZ2 (if available)
Gene Tree for AMZ2 (if available)

Paralogs for AMZ2 Gene

Paralogs for AMZ2 Gene

(2) SIMAP similar genes for AMZ2 Gene using alignment to 9 proteins: Pseudogenes for AMZ2 Gene

genes like me logo Genes that share paralogs with AMZ2: view

Variants for AMZ2 Gene

Sequence variations from dbSNP and Humsavar for AMZ2 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs782698957 Uncertain significance 68,251,113(+) AATAA(A/C/T)AATGA nc-transcript-variant, reference, missense
rs1001304402 -- 68,210,094(+) AGAAT(C/G)TAAAA intron-variant
rs1004865159 -- 68,209,832(+) GCCAG(C/G/T)CTGGT intron-variant
rs1005478392 -- 68,209,586(+) GGTGT(C/G)TGTGT intron-variant
rs1009456099 -- 68,209,561(+) AATAT(C/T)ATAGA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for AMZ2 Gene

Variant ID Type Subtype PubMed ID
esv2716143 CNV deletion 23290073
esv2716144 CNV deletion 23290073
esv2716145 CNV deletion 23290073
esv2716146 CNV deletion 23290073
nsv1116234 CNV deletion 24896259
nsv960148 CNV duplication 23825009

Variation tolerance for AMZ2 Gene

Residual Variation Intolerance Score: 59.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.68; 32.10% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for AMZ2 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for AMZ2 Gene

Disorders for AMZ2 Gene

Relevant External Links for AMZ2

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for AMZ2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for AMZ2 Gene

Publications for AMZ2 Gene

  1. Identification and characterization of human archaemetzincin-1 and - 2, two novel members of a family of metalloproteases widely distributed in Archaea. (PMID: 15972818) Diaz-Perales A. … Lopez-Otin C. (J. Biol. Chem. 2005) 2 3 4 22 64
  2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 46 64
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  5. Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. (PMID: 11042152) Zhang Q.-H. … Chen Z. (Genome Res. 2000) 3 4 64

Products for AMZ2 Gene

Sources for AMZ2 Gene

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