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Aliases for AMZ2 Gene

Aliases for AMZ2 Gene

  • Archaelysin Family Metallopeptidase 2 2 3
  • Archeobacterial Metalloproteinase-Like Protein 2 3 4
  • Archaemetzincins-2 3
  • Archaemetzincin-2 2
  • EC 3.4.-.- 4

External Ids for AMZ2 Gene

Previous GeneCards Identifiers for AMZ2 Gene

  • GC17P063756
  • GC17P066244
  • GC17P061630

Summaries for AMZ2 Gene

GeneCards Summary for AMZ2 Gene

AMZ2 (Archaelysin Family Metallopeptidase 2) is a Protein Coding gene. GO annotations related to this gene include metallopeptidase activity. An important paralog of this gene is AMZ1.

UniProtKB/Swiss-Prot for AMZ2 Gene

  • Zinc metalloprotease. Exhibits activity against angiotensin-3 in vitro. Does not hydrolyze either neurogranin or angiotensin-2.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for AMZ2 Gene

Genomics for AMZ2 Gene

Regulatory Elements for AMZ2 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for AMZ2 Gene

68,205,997 bp from pter
68,257,164 bp from pter
51,168 bases
Plus strand

Genomic View for AMZ2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for AMZ2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for AMZ2 Gene

Proteins for AMZ2 Gene

  • Protein details for AMZ2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein Accession:
    Secondary Accessions:
    • A6NLD9
    • B3KR44
    • Q5XKF1
    • Q9NZE2

    Protein attributes for AMZ2 Gene

    360 amino acids
    Molecular mass:
    41263 Da
    Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Note=Binds 2 Zn(2+) ions per subunit. One is catalytic, whereas the other seems to have a structural role.;
    Quaternary structure:
    No Data Available
    • Sequence=AAF64270.1; Type=Erroneous termination; Positions=98; Note=Translated as Gly.; Evidence={ECO:0000305}; Sequence=AAF64270.1; Type=Frameshift; Positions=55; Evidence={ECO:0000305};

    Alternative splice isoforms for AMZ2 Gene


neXtProt entry for AMZ2 Gene

Proteomics data for AMZ2 Gene at MOPED

Post-translational modifications for AMZ2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

No data available for DME Specific Peptides for AMZ2 Gene

Domains & Families for AMZ2 Gene

Protein Domains for AMZ2 Gene

Suggested Antigen Peptide Sequences for AMZ2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the peptidase M54 family.
  • Belongs to the peptidase M54 family.
genes like me logo Genes that share domains with AMZ2: view

No data available for Gene Families for AMZ2 Gene

Function for AMZ2 Gene

Molecular function for AMZ2 Gene

UniProtKB/Swiss-Prot BiophysicochemicalProperties:
pH dependence: Optimum pH is 7.0. {ECO:0000269 PubMed:15972818};
UniProtKB/Swiss-Prot EnzymeRegulation:
Inhibited by the general metalloprotease inhibitors o-phenanthroline and batimastat. Also significantly inhibited by amastatin, which is an inhibitor of aminopeptidases. Not inhibited by 4-(2-aminoethyl)-benzenesulfonyl fluoride, E-64, and TIMPS (tissue inhibitors of metalloproteinases), which are inhibitors of serine, cysteine, and matrix metalloproteases, respectively.
UniProtKB/Swiss-Prot Function:
Zinc metalloprotease. Exhibits activity against angiotensin-3 in vitro. Does not hydrolyze either neurogranin or angiotensin-2.

Enzyme Numbers (IUBMB) for AMZ2 Gene

Gene Ontology (GO) - Molecular Function for AMZ2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008237 metallopeptidase activity IEA --
GO:0008270 zinc ion binding IEA --
genes like me logo Genes that share ontologies with AMZ2: view
genes like me logo Genes that share phenotypes with AMZ2: view

Animal Model Products

miRNA for AMZ2 Gene

miRTarBase miRNAs that target AMZ2

No data available for Animal Models , Transcription Factor Targets and HOMER Transcription for AMZ2 Gene

Localization for AMZ2 Gene

Subcellular locations from

Jensen Localization Image for AMZ2 Gene COMPARTMENTS Subcellular localization image for AMZ2 gene
Compartment Confidence
cytosol 2
nucleus 2

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for AMZ2 Gene

Pathways & Interactions for AMZ2 Gene

SuperPathways for AMZ2 Gene

No Data Available

Interacting Proteins for AMZ2 Gene

Gene Ontology (GO) - Biological Process for AMZ2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006508 proteolysis IEA --
genes like me logo Genes that share ontologies with AMZ2: view

No data available for Pathways by source and SIGNOR curated interactions for AMZ2 Gene

Drugs & Compounds for AMZ2 Gene

No Compound Related Data Available

Transcripts for AMZ2 Gene

Unigene Clusters for AMZ2 Gene

Archaelysin family metallopeptidase 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for AMZ2 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c ^ 3a · 3b · 3c ^ 4 ^ 5a · 5b · 5c · 5d · 5e ^ 6a · 6b · 6c · 6d · 6e ^ 7 ^ 8a · 8b ^ 9 ^ 10
SP1: - - - -
SP3: - - - - - - -
SP4: - - - - - - -
SP5: - - - - -
SP6: - - -
SP7: - -
SP9: -
SP10: - - - - - -

Relevant External Links for AMZ2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for AMZ2 Gene

mRNA expression in normal human tissues for AMZ2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for AMZ2 Gene

This gene is overexpressed in Testis (31.1), Ovary (14.6), and Fetal Brain (10.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MOPED, and MaxQB for AMZ2 Gene

SOURCE GeneReport for Unigene cluster for AMZ2 Gene Hs.293560

mRNA Expression by UniProt/SwissProt for AMZ2 Gene

Tissue specificity: Predominantly expressed in heart and testis. Also expressed at lower levels in kidney, liver, pancreas, lung, brain and placenta. Expressed in fetal tissues such as kidney, liver, lung and brain. Down-regulated in testis from patients with maturation arrest (MA) or Sertoli cell-only syndrome (SCOS).
genes like me logo Genes that share expression patterns with AMZ2: view

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and Protein tissue co-expression partners for AMZ2 Gene

Orthologs for AMZ2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for AMZ2 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia AMZ2 35
  • 80.51 (n)
  • 80.61 (a)
AMZ2 36
  • 81 (a)
(Canis familiaris)
Mammalia AMZ2 35
  • 88.89 (n)
  • 86.11 (a)
AMZ2 36
  • 86 (a)
(Mus musculus)
Mammalia Amz2 35
  • 81.62 (n)
  • 79.39 (a)
Amz2 16
Amz2 36
  • 79 (a)
(Rattus norvegicus)
Mammalia Amz2 35
  • 79.67 (n)
  • 79.67 (a)
(Ornithorhynchus anatinus)
Mammalia AMZ2 36
  • 58 (a)
(Pan troglodytes)
Mammalia AMZ2 36
  • 98 (a)
(Anolis carolinensis)
Reptilia AMZ2 36
  • 67 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100494774 35
  • 62.86 (n)
  • 59.78 (a)
(Danio rerio)
Actinopterygii AMZ2 (1 of 2) 36
  • 41 (a)
AMZ2 (2 of 2) 36
  • 51 (a)
Species with no ortholog for AMZ2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for AMZ2 Gene

Gene Tree for AMZ2 (if available)
Gene Tree for AMZ2 (if available)

Paralogs for AMZ2 Gene

Paralogs for AMZ2 Gene

(2) SIMAP similar genes for AMZ2 Gene using alignment to 9 proteins: Pseudogenes for AMZ2 Gene

genes like me logo Genes that share paralogs with AMZ2: view

Variants for AMZ2 Gene

Sequence variations from dbSNP and Humsavar for AMZ2 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
rs758150 -- 68,221,219(-) ggggg(C/G)ggggg intron-variant
rs1060687 -- 68,214,233(-) GAAAA(A/T)CATCC intron-variant
rs1076330 -- 68,221,136(+) GGAGT(A/G)CAGAA intron-variant
rs1808249 -- 68,227,346(-) TACCC(A/G)GGCTC intron-variant
rs1811217 -- 68,207,891(-) AGCAC(C/G)GCTCG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for AMZ2 Gene

Variant ID Type Subtype PubMed ID
esv2716143 CNV Deletion 23290073
esv2716144 CNV Deletion 23290073
esv2716145 CNV Deletion 23290073
esv2716146 CNV Deletion 23290073

Variation tolerance for AMZ2 Gene

Residual Variation Intolerance Score: 59.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.68; 32.10% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for AMZ2 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for AMZ2 Gene

Disorders for AMZ2 Gene

Relevant External Links for AMZ2

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with AMZ2: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for AMZ2 Gene

Publications for AMZ2 Gene

  1. Identification and characterization of human archaemetzincin-1 and - 2, two novel members of a family of metalloproteases widely distributed in Archaea. (PMID: 15972818) Diaz-Perales A. … Lopez-Otin C. (J. Biol. Chem. 2005) 2 23 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 67
  3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 67
  4. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PMID: 17207965) Lamesch P. … Vidal M. (Genomics 2007) 67
  5. Identification of ten novel genes involved in human spermatogenesis by microarray analysis of testicular tissue. (PMID: 17074343) Lin Y.H. … Kuo P.L. (Fertil. Steril. 2006) 67

Products for AMZ2 Gene

Sources for AMZ2 Gene

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