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Aliases for AMZ1 Gene

Aliases for AMZ1 Gene

  • Archaelysin Family Metallopeptidase 1 2 3 5
  • Archeobacterial Metalloproteinase-Like Protein 1 4
  • Archaemetzincin-1 2
  • EC 3.4.-.- 4
  • KIAA1950 4

External Ids for AMZ1 Gene

Previous GeneCards Identifiers for AMZ1 Gene

  • GC07P002493
  • GC07P002685

Summaries for AMZ1 Gene

GeneCards Summary for AMZ1 Gene

AMZ1 (Archaelysin Family Metallopeptidase 1) is a Protein Coding gene. GO annotations related to this gene include metallopeptidase activity. An important paralog of this gene is AMZ2.

UniProtKB/Swiss-Prot for AMZ1 Gene

  • Zinc metalloprotease. Exhibits aminopeptidase activity against neurogranin in vitro. Does not hydrolyze angiotensin-2.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for AMZ1 Gene

Genomics for AMZ1 Gene

Regulatory Elements for AMZ1 Gene

Enhancers for AMZ1 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around AMZ1 on UCSC Golden Path with GeneCards custom track

Genomic Location for AMZ1 Gene

2,679,522 bp from pter
2,775,500 bp from pter
95,979 bases
Plus strand

Genomic View for AMZ1 Gene

Genes around AMZ1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
AMZ1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for AMZ1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for AMZ1 Gene

Proteins for AMZ1 Gene

  • Protein details for AMZ1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein Accession:
    Secondary Accessions:
    • B3KRS0
    • Q8TF51

    Protein attributes for AMZ1 Gene

    498 amino acids
    Molecular mass:
    54924 Da
    Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
    Quaternary structure:
    No Data Available
    • Sequence=BAB85536.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for AMZ1 Gene


neXtProt entry for AMZ1 Gene

Proteomics data for AMZ1 Gene at MOPED

Post-translational modifications for AMZ1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for AMZ1 Gene

No data available for DME Specific Peptides for AMZ1 Gene

Domains & Families for AMZ1 Gene

Protein Domains for AMZ1 Gene


Graphical View of Domain Structure for InterPro Entry



  • Belongs to the peptidase M54 family.
  • Belongs to the peptidase M54 family.
genes like me logo Genes that share domains with AMZ1: view

No data available for Gene Families for AMZ1 Gene

Function for AMZ1 Gene

Molecular function for AMZ1 Gene

UniProtKB/Swiss-Prot BiophysicochemicalProperties:
pH dependence: Optimum pH is 8.0. {ECO:0000269 PubMed:15972818};
UniProtKB/Swiss-Prot EnzymeRegulation:
Inhibited by the general metalloprotease inhibitors o-phenanthroline and batimastat. Also significantly inhibited by amastatin, which is an inhibitor of aminopeptidases. Not inhibited by 4-(2-aminoethyl)-benzenesulfonyl fluoride, E-64, and TIMPS (tissue inhibitors of metalloproteinases), which are inhibitors of serine, cysteine, and matrix metalloproteases, respectively.
UniProtKB/Swiss-Prot Function:
Zinc metalloprotease. Exhibits aminopeptidase activity against neurogranin in vitro. Does not hydrolyze angiotensin-2.

Enzyme Numbers (IUBMB) for AMZ1 Gene

Gene Ontology (GO) - Molecular Function for AMZ1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008270 zinc ion binding IEA --
genes like me logo Genes that share ontologies with AMZ1: view

Phenotypes for AMZ1 Gene

genes like me logo Genes that share phenotypes with AMZ1: view

Animal Model Products

CRISPR Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for AMZ1 Gene

Localization for AMZ1 Gene

Subcellular locations from

Jensen Localization Image for AMZ1 Gene COMPARTMENTS Subcellular localization image for AMZ1 gene
Compartment Confidence
cytosol 2
nucleus 2
peroxisome 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for AMZ1 Gene

Pathways & Interactions for AMZ1 Gene

SuperPathways for AMZ1 Gene

No Data Available

Interacting Proteins for AMZ1 Gene

Gene Ontology (GO) - Biological Process for AMZ1 Gene


No data available for Pathways by source and SIGNOR curated interactions for AMZ1 Gene

Drugs & Compounds for AMZ1 Gene

No Compound Related Data Available

Transcripts for AMZ1 Gene

mRNA/cDNA for AMZ1 Gene

Unigene Clusters for AMZ1 Gene

Archaelysin family metallopeptidase 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for AMZ1 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9
SP1: - -
SP2: - -
SP3: -

Relevant External Links for AMZ1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for AMZ1 Gene

mRNA expression in normal human tissues for AMZ1 Gene

mRNA differential expression in normal tissues according to GTEx for AMZ1 Gene

This gene is overexpressed in Brain - Amygdala (x5.3), Brain - Nucleus accumbens (basal ganglia) (x4.6), and Brain - Putamen (basal ganglia) (x4.3).

Protein differential expression in normal tissues from HIPED for AMZ1 Gene

This gene is overexpressed in Liver (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for AMZ1 Gene

SOURCE GeneReport for Unigene cluster for AMZ1 Gene Hs.42221

mRNA Expression by UniProt/SwissProt for AMZ1 Gene

Tissue specificity: Predominantly expressed in heart and liver. Also expressed at lower level in kidney, pancreas and testis. Expressed in fetal tissues such as kidney, liver, lung and brain.
genes like me logo Genes that share expression patterns with AMZ1: view

Protein tissue co-expression partners for AMZ1 Gene

- Elite partner

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for AMZ1 Gene

Orthologs for AMZ1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for AMZ1 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia AMZ1 35
  • 81.6 (n)
  • 77.8 (a)
AMZ1 36
  • 76 (a)
(Canis familiaris)
Mammalia AMZ1 35
  • 81.99 (n)
  • 78.11 (a)
AMZ1 36
  • 77 (a)
(Mus musculus)
Mammalia Amz1 35
  • 78.07 (n)
  • 74.04 (a)
Amz1 16
Amz1 36
  • 73 (a)
(Pan troglodytes)
Mammalia AMZ1 35
  • 98.8 (n)
  • 99 (a)
AMZ1 36
  • 99 (a)
(Rattus norvegicus)
Mammalia Amz1 35
  • 77.33 (n)
  • 75.86 (a)
(Monodelphis domestica)
Mammalia AMZ1 36
  • 67 (a)
(Ornithorhynchus anatinus)
Mammalia AMZ1 36
  • 68 (a)
(Gallus gallus)
Aves AMZ1 35
  • 69.9 (n)
  • 66.67 (a)
AMZ1 36
  • 65 (a)
(Anolis carolinensis)
Reptilia AMZ1 36
  • 64 (a)
Species with no ortholog for AMZ1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for AMZ1 Gene

Gene Tree for AMZ1 (if available)
Gene Tree for AMZ1 (if available)

Paralogs for AMZ1 Gene

Paralogs for AMZ1 Gene

(2) SIMAP similar genes for AMZ1 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with AMZ1: view

Variants for AMZ1 Gene

Sequence variations from dbSNP and Humsavar for AMZ1 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
rs7776970 - 2,712,853(+) CCCCC(A/G/T)TCCCT intron-variant, reference, missense, utr-variant-3-prime
rs798461 -- 2,705,667(-) ACCCC(A/C)AAATC intron-variant
rs798462 -- 2,704,243(-) ttaca(G/T)gtgtg intron-variant
rs798463 -- 2,704,168(-) ctcac(A/G/T)cctat intron-variant
rs798464 -- 2,704,123(-) tcatg(A/C)ggtca intron-variant

Structural Variations from Database of Genomic Variants (DGV) for AMZ1 Gene

Variant ID Type Subtype PubMed ID
nsv471227 CNV Loss 18288195
dgv401n21 CNV Loss 19592680
dgv7121n71 CNV Loss 21882294
dgv7122n71 CNV Loss 21882294
nsv464257 CNV Loss 19166990
nsv464258 CNV Loss 19166990
nsv887312 CNV Loss 21882294
esv2670827 CNV Deletion 23128226

Variation tolerance for AMZ1 Gene

Residual Variation Intolerance Score: 99.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.44; 85.66% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for AMZ1 Gene

Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for AMZ1 Gene

Disorders for AMZ1 Gene

Relevant External Links for AMZ1

Genetic Association Database (GAD)
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for AMZ1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for AMZ1 Gene

Publications for AMZ1 Gene

  1. Identification and characterization of human archaemetzincin-1 and - 2, two novel members of a family of metalloproteases widely distributed in Archaea. (PMID: 15972818) Diaz-Perales A. … Lopez-Otin C. (J. Biol. Chem. 2005) 2 3 4 23 67
  2. Genome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture. (PMID: 23563607) Berndt S.I. … Ingelsson E. (Nat. Genet. 2013) 3
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3
  4. Human chromosome 7: DNA sequence and biology. (PMID: 12690205) Scherer S.W. … Tsui L.-C. (Science 2003) 3
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3

Products for AMZ1 Gene

Sources for AMZ1 Gene