AMZ1 Gene
protein-coding GIFtS: 43
GCID: GC07P002719
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|
archaelysin family metallopeptidase 1
| |
Aliases
for AMZ1 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Archaelysin Family Metallopeptidase 11 2 | | KIAA19501 3 | | Archeobacterial Metalloproteinase-Like Protein 12 3 | | Archaemetzincin-11 | | Metalloproteinase-Like Protein2 | | EC 3.4.-.-3 |
Export aliases for AMZ1 gene to outside databasesPrevious GC identifers: GC07P002493 GC07P002685 |
Summaries
for AMZ1 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: AMZ1_HUMAN, Q400G9Function: Zinc metalloprotease. Exhibits aminopeptidase activity against neurogranin in vitro. Does not hydrolyzeangiotensin-2
|
Genomic Views
for AMZ1 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000007.13 NC_018918.1 NT_007819.17 NT_079592.2
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the AMZ1 gene promoter:
COUP-TF1 COUP-TF CP2 AML1a GATA-3 POU2F1 POU2F1a COUP
Other transcription factors
Search SABiosciences Chromatin IP Primers for AMZ1
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat AMZ1 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 7p22.3 Ensembl cytogenetic band: 7p22.3 HGNC cytogenetic band: 7p22.3AMZ1 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 7 GeneLoc Exon Structure GeneLoc location for GC07P002719: view genomic region
(about GC identifiers)
Start:
|
2,719,156 bp from pter |
End:
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2,804,759 bp from pter |
Size:
|
85,604 bases |
Orientation:
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plus strand |
1 alternative location:
| Chr7+,CRA_TCAG 2,767,050-2,802,975 |
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Proteins
for AMZ1 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: AMZ1_HUMAN, Q400G9 (See
protein sequence)Recommended Name: Archaemetzincin-1 Size: 498 amino acids; 54924 Da
Cofactor: Binds 2 zinc ions per subunit. One is catalytic, whereas the other seems to have a structural role (Bysimilarity)
Sequence caution: Sequence=BAB85536.1; Type=Erroneous initiation;
Secondary accessions: Q8TF51Explore the universe of human proteins at neXtProt for AMZ1: NX_Q400G9
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q400G9
AMZ1 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_597720.1
ENSEMBL proteins: ENSP00000308149 ENSP00000386020
Human Recombinant Protein Products:
AMZ1 Antibody Products:
Assay Products for AMZ1: |
Protein
Domains /
Families
for AMZ1 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
AMZ1 for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q400G9ProtoNet protein and cluster: Q400G9 UniProtKB/Swiss-Prot: AMZ1_HUMAN, Q400G9Similarity: Belongs to the peptidase M54 family |
Function
for AMZ1 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: AMZ1_HUMAN, Q400G9Function: Zinc metalloprotease. Exhibits aminopeptidase activity against neurogranin in vitro. Does not hydrolyzeangiotensin-2Enzyme regulation: Inhibited by the general metalloprotease inhibitors o-phenanthroline and batimastat. Alsosignificantly inhibited by amastatin, which is an inhibitor of aminopeptidases. Not inhibited by4-(2-aminoethyl)-benzenesulfonyl fluoride, E-64, and TIMPS (tissue inhibitors of metalloproteinases), which areinhibitors of serine, cysteine, and matrix metalloproteases, respectivelyBiophysicochemical properties: pH dependence: Optimum pH is 8.0;Enzyme Number (IUBMB): EC 3.4.-.-1
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for AMZ1 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for AMZ1
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
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| |  | GenScript: all cDNA clones in your preferred vector: AMZ1 (NM_133463) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for AMZ1 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat AMZ1 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for AMZ1 |
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0008237 | metallopeptidase activity |
IEA | -- | | GO:0008270 | zinc ion binding |
IEA | -- |
AMZ1 for ontologies About GeneDecksing
|
Pathways & Interactions
for AMZ1 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for AMZ1
Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006508 | proteolysis |
IEA | -- |
AMZ1 for ontologies About GeneDecksing
|
Drugs & Compounds
for AMZ1 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for AMZ1
Search CenterWatch for drugs/clinical trials and news about AMZ1
|
Transcripts
for AMZ1 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for AMZ1 gene: NM_133463.1 Unigene Cluster for AMZ1: Archaelysin family metallopeptidase 1 Hs.42221 [show with all ESTs]Unigene Representative Sequence: BC1467535 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000312371(uc003smr.1 uc003sms.1 uc011jwa.1) ENST00000407112
ENST00000485540 ENST00000480560 ENST00000489665
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for AMZ1 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for AMZ1
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: AMZ1 (NM_133463) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for AMZ1 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat AMZ1 |
Additional cDNA sequence: AB075830.1 AJ635357.1 AK092107.1 AK289723.1 AK295842.1 AK308900.1 AK311182.1 BC146753.1 3 DOTS entries: DT.40112190 DT.92009897 DT.40109272 10 AceView cDNA sequences: AB075830 BE208047 AK092107 AX747357 BE336821 BG818609 N43820 H96670 N35080 BI260666
GeneLoc Exon Structure
3 Alternative Splicing Database (ASD) splice patterns (SP) for AMZ1 About this scheme
| ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 |
|---|
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| SP1: | | | - | | | | - | | | | | | | | | | | | |
| SP2: | | | | | | | - | | | | | | - | | | | | | |
| SP3: | | | | | | | | | | | | | - | | | | | |
ECgene alternative splicing isoforms for AMZ1
|
Expression
for AMZ1 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| AMZ1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GTGAGACTCT
About this image
See AMZ1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for AMZ1
SOURCE GeneReport for Unigene cluster: Hs.42221
UniProtKB/Swiss-Prot: AMZ1_HUMAN, Q400G9Tissue specificity: Predominantly expressed in heart and liver. Also expressed at lower level in kidney, pancreas andtestis. Expressed in fetal tissues such as kidney, liver, lung and brain
SABiosciences Custom PCR Arrays for AMZ1
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for AMZ1
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat AMZ1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat AMZ1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat AMZ1 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for AMZ1 |
Orthologs
for AMZ1 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for AMZ1 gene from 3/11 species (see all 11) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
AMZ11 |
archaelysin family metallopeptidase 1 |
69.49(n)
66.13(a) |
|
416474 XM_414779.2 XP_414779.2 |
lizard
(Anolis carolinensis) |
Reptilia |
AMZ16 |
-- |
64(a) |
1 ↔ 1 |
GL343340.1(385147-391071) |
zebrafish
(Danio rerio) |
Actinopterygii |
CABZ01038699.16 |
-- |
31(a) |
1 → many |
12(21909237-21913265) |
ENSEMBL Gene Tree for AMZ1 (if available)
TreeFam Gene Tree for AMZ1 (if available) |
Paralogs
for AMZ1 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for AMZ1 gene
- AMZ22
2 SIMAP similar genes for AMZ1 using alignment to 2 protein entries: AMZ1_HUMAN (see all proteins):KIAA1950 AMZ2
AMZ1 for paralogs About GeneDecksing
|
Genomic Variants
for AMZ1 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 7 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for AMZ1 (2719156 - 2804759 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 2 variations for AMZ1
2 CNVs: 30256 30255 | SABiosciences Cancer Mutation PCR Assays |
|
Disorders
/ Diseases
for AMZ1 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
| -- |
Publications
for AMZ1 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for AMZ1 gene integrated from 9 sources:
(articles sorted by number of sources associating them with AMZ1) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Identification and characterization of human archaemetzincin-1 and - 2, two novel members of a family of metalloproteases widely distributed in Archaea. (PubMed id 15972818)1, 2, 3, 9 Diaz-Perales A.... Lopez-Otin C. (2005)
- Prediction of the coding sequences of unidentified human genes. XXII. The complete sequences of 50 new cDNA clones which code for large proteins. (PubMed id 11853319)1, 2 Nagase T.... Ohara O. (2001)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1 Ota T.... Sugano S. (2004)
- Human chromosome 7: DNA sequence and biology. (PubMed id 12690205)1 Scherer S.W.... Tsui L.-C. (2003)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
|
External Searches for AMZ1 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing AMZ1 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing AMZ1 gene
(According to HUGE)
About This Section
| |
Specialized Databases showing AMZ1 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for AMZ1 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for AMZ1 gene:
Search GeneIP for patents involving AMZ1
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for AMZ1 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat AMZ1 | | | Search QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing AMZ1 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat AMZ1 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat AMZ1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat AMZ1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat AMZ1 |
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| | | | Search Tocris compounds for AMZ1 |
| |  |  |  |  | | | | |
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 |
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 | | | AMZ1 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for AMZ1 |
|  |  |  | | | | Search ThermoFisher Antibodies for AMZ1 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat AMZ1 |
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