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AMY2B Gene

protein-coding   GIFtS: 58
GCID: GC01P104096

Amylase, Alpha 2B (Pancreatic)

(Previous names: amylase, alpha 2B; pancreatic)
(Previous symbol: AMY2)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Amylase, Alpha 2B (Pancreatic)1 2     Amylase, Alpha 2B; Pancreatic1
AMY21 2     AMY32
Carcinoid Alpha-Amylase2 3     HXA2
1,4-Alpha-D-Glucan Glucanohydrolase 2B2 3     Alpha-Amylase 2B2
EC 3.2.1.13 8     glycogenase2

External Ids:    HGNC: 4781   Entrez Gene: 2802   Ensembl: ENSG000002400387   OMIM: 1046605   UniProtKB: P199613   

Export aliases for AMY2B gene to outside databases

Previous GC identifers: GC01P104761 GC01P103104 GC01P103251 GC01P103424 GC01P103426 GC01P103781 GC01P103809 GC01P103897 GC01P102153


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for AMY2B Gene:
Amylases are secreted proteins that hydrolyze 1,4-alpha-glucoside bonds in oligosaccharides and polysaccharides,
and thus catalyze the first step in digestion of dietary starch and glycogen. The human genome has a cluster of
several amylase genes that are expressed at high levels in either salivary gland or pancreas. This gene encodes
an amylase isoenzyme produced by the pancreas. (provided by RefSeq, Jun 2013)

GeneCards Summary for AMY2B Gene:
AMY2B (amylase, alpha 2B (pancreatic)) is a protein-coding gene. Diseases associated with AMY2B include pancreatitis, and thyroiditis. GO annotations related to this gene include alpha-amylase activity. An important paralog of this gene is AMY1A.

Gene Wiki entry for AMY2B Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000001.11  NC_018912.2  NT_032977.10  
Regulatory elements:
   Regulatory transcription factor binding sites in the AMY2B gene promoter:
         FOXF2   Nkx2-2   FOXD1   RelA   Evi-1   FAC1   c-Rel   FOXC1   FOXO4   IRF-7A   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidAMY2B promoter sequence
   Search Chromatin IP Primers for AMY2B

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat AMY2B


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p21   Ensembl cytogenetic band:  1p21.1   HGNC cytogenetic band: 1p21

AMY2B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
AMY2B gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P104096:  view genomic region     (about GC identifiers)

Start:
104,096,437 bp from pter      End:
104,122,156 bp from pter
Size:
25,720 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: AMY2B_HUMAN, P19961 (See protein sequence)
Recommended Name: Alpha-amylase 2B precursor  
Size: 511 amino acids; 57710 Da
Cofactor: Binds 1 calcium ion per subunit (By similarity)
Cofactor: Binds 1 chloride ion per subunit (By similarity)
Subunit: Monomer (By similarity)
Secondary accessions: B3KXB7 D3DT76 Q9UBH3

Explore the universe of human proteins at neXtProt for AMY2B: NX_P19961

Explore proteomics data for AMY2B at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for AMY2B (P19961) (see all 23)
     YMNHLID  GVRIYVD  YCDVISG  DNHDNQR 


    See AMY2B Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_066188.1  
    ENSEMBL proteins: 
     ENSP00000433347   ENSP00000354610   ENSP00000391423   ENSP00000401627  
    Reactome Protein details: P19961

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    Selected InterPro protein domains (see all 8):
     IPR006046 Alpha_amylase
     IPR006048 A-amylase_b_C
     IPR017853 Glycoside_hydrolase_SF
     IPR006047 Glyco_hydro_13_cat_dom
     IPR013781 Glyco_hydro_catalytic_dom

    Graphical View of Domain Structure for InterPro Entry P19961

    ProtoNet protein and cluster: P19961

    3 Blocks protein domains:
    IPB006046 Alpha-amylase signature
    IPB006048 Alpha amylase
    IPB006589 Alpha amylase


    UniProtKB/Swiss-Prot: AMY2B_HUMAN, P19961
    Similarity: Belongs to the glycosyl hydrolase 13 family


    AMY2B for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: AMY2B_HUMAN, P19961
    Catalytic activity: Endohydrolysis of (1->4)-alpha-D-glucosidic linkages in polysaccharides containing three or
    more (1->4)-alpha-linked D-glucose units

         Genatlas biochemistry entry for AMY2B:
    amylase,alpha-2B,liver,pancreas,see AMY@

         Enzyme Number (IUBMB): EC 3.2.1.11 2

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003824catalytic activity ----
    GO:0004556alpha-amylase activity IEA--
    GO:0043169cation binding ----
    GO:0046872metal ion binding IEA--
         
    AMY2B for ontologies           About GeneDecksing


    Animal Models:
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    AMY2B_HUMAN, P19961: Secreted (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular5
    cytosol1
    endoplasmic reticulum1
    lysosome1
    mitochondrion1
    peroxisome1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region IEA--

    AMY2B for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for AMY2B About   (see all 7)  
    See pathways by source

    SuperPathContained pathways About
    1Metabolism
    Metabolism0.38
    Metabolic pathways0.38
    2MPS VI - Maroteaux-Lamy syndrome
    Metabolism of carbohydrates0.45
    3Glucuronidation
    Starch and sucrose metabolism0.41
    4Pancreatic secretion
    Pancreatic secretion
    5Glucose / Energy Metabolism
    Glucose / Energy Metabolism

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Cell Signaling Technology (CST) Pathway for AMY2B
        Glucose / Energy Metabolism


    1 Reactome Pathway for AMY2B
        Digestion of dietary carbohydrate


    4 Kegg Pathways  (Kegg details for AMY2B):
        Starch and sucrose metabolism
    Metabolic pathways
    Pancreatic secretion
    Carbohydrate digestion and absorption


    AMY2B for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for AMY2B
    Interactions:

        Search GeneGlobe Interaction Network for AMY2B

    2 Interacting proteins for AMY2B (P199613) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ATG101Q9BSB43I2D: score=1 
    FOSP011003I2D: score=1 
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005975carbohydrate metabolic process IEA--
    GO:0007586digestion TAS2401405

    AMY2B for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for AMY2B

    7 HMDB Compounds for AMY2B    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--
    ChlorineCl2 (see all 13)16887-00-6--
    DextrinCaloreen (see all 10)9004-53-9--
    MaltodecaoseB-cyclodextrin (see all 19)37331-89-8--
    Maltoheptaosemaltoheptose;alpha-D-Glc-(1->4)-alpha-D-Glc-(1->4)-alpha-D-Glc-(1->4)-alpha-D-Glc-(1->4)-alpha-D-Glc-(1->4)-alpha-D-Glc-(1->4)-D-Glc;Glc(alpha1-4)Glc(alpha1-4)Glc(alpha1-4)Glc(alpha1-4)Glc(alpha1-4)Glc(alpha1-4)Glc 34620-77-4--
    Maltononaosemaltonanoose 6471-60-9--
    WaterDihydrogen oxide (see all 2)7732-18-5--

    10 DrugBank Compounds for AMY2B    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    1,4-Dithio-Alpha-D-Mannose-- --target--17139284 17016423 10592235
    4-Methylthio-Alpha-D-Mannose-- --target--17139284 17016423 10592235
    5-Hydroxymethyl-Chonduritol-- --target--17139284 17016423 10592235
    Alpha-D-Mannose-- 3458-28-4target--17139284 17016423 10592235
    Amylotriose-- 1109-28-0target--17139284 17016423 10592235
    Beta-D-Glucose-- 50-99-7target--17139284 17016423 10592235
    Maltose-- 69-79-4target--17139284 17016423 10592235
    N-[4-Hydroxymethyl-Cyclohexan-6-Yl-1,2,3-Triol]-4,6-Dideoxy-4-Aminoglucopyranoside-- --target--17139284 17016423 10592235
    P-Nitrophenol-- 100-02-7target--17139284 17016423 10592235
    Pyroglutamic Acid-- 98-79-3target--17139284 17016423 10592235

    5 Novoseek inferred chemical compound relationships for AMY2B gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    maltoheptaose 84.4 1 14511369 (1)
    amylose 78.3 2 15356864 (1), 14511369 (1)
    acarbose 70.3 3 14511369 (2)
    starch 67.3 3 16030022 (1), 12906828 (1), 18467868 (1)
    calcium 7.62 1 18467868 (1)



    AMY2B for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for AMY2B gene: 
    NM_020978.4  

    Unigene Cluster for AMY2B:

    Amylase, alpha 2B (pancreatic)
    Hs.484588  [show with all ESTs]
    Unigene Representative Sequence: AK127047
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000477657(uc001duq.3) ENST00000361355(uc010ouo.2 uc001dus.1)
    ENST00000435302 ENST00000453959 ENST00000491397(uc001dur.3) ENST00000462971
    ENST00000481821
    miRNA
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    Additional mRNA sequence: 

    AK095605.1 AK127047.1 BC011179.1 BC020861.1 DQ786288.1 M24895.1 

    21 DOTS entries:

    DT.449355  DT.100892344  DT.315416  DT.121339942  DT.75131378  DT.92447694  DT.92447688  DT.91672656 
    DT.92447700  DT.75130100  DT.103928  DT.121339866  DT.92061564  DT.95155090  DT.121339838  DT.121339842 
    DT.121339870  DT.100892335  DT.100892336  DT.40220827  DT.92068068 

    Selected AceView cDNA sequences (see all 222):

    AU137618 AL832291 BM670675 CR601909 CR615091 CR592251 AL705057 BC011179 
    AW978322 BC010697 CR616713 AK057799 AI932359 CA447262 CA950654 CA441626 
    R56117 M24895 AK127047 CR593744 NM_020978 AL704039 BX485594 Z44595 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    AMY2B expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CTGAATCTAA
    AMY2B Expression
    About this image


    AMY2B expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 2) fully expand
     
     Amnion (Extraembryonic Tissues)
             Amniotic Epithelial Cells Amniotic Membrane
     
     Pancreas (Endocrine System)
    AMY2B Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    AMY2B Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.484588
        Custom PCR Arrays for AMY2B
    Primer
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for AMY2B

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for AMY2B gene from Selected species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Amy2a51 amylase 2a5 84.51(n)
    85.24(a)
      109959  NM_001042711.2  NP_001036176.1 
    chicken
    (Gallus gallus)
    Aves AMY2A6
    AMY1A6
    Gallus gallus amylase, alpha 2A; pancreatic (AMY2A...
    Gallus gallus amylase, alpha 1A; salivary (AMY1A),...
    82(a)
    79(a)
    many ↔ many
    many ↔ many
    8(41570-46009)
    8(10001375-10007677)
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    80(a)
    1 → many
    4(85537665-85554909)
    African clawed frog
    (Xenopus laevis)
    Amphibia MGC643372 alpha-amylase precursor 76.79(n)    BC056841.1 
    zebrafish
    (Danio rerio)
    Actinopterygii amy2a1 amylase, alpha 2A; pancreatic 69.21(n)
    73.39(a)
      406539  NM_213011.1  NP_998176.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Amy-p1 , 3 alpha-amylase3
    Amylase proximal1
    51(a)
    (best of 3)3
    55.81(n)1
    56.15(a)1
      2 53F123
    477641  NM_080421.31  NP_536346.11 
    worm
    (Caenorhabditis elegans)
    Secernentea C50B6.73
    CELE_C50B6.71
    amylase3
    CELE_C50B6.71
    44(a)3
    55.33(n)1
    50.31(a)1
      V(13325025-13327571)3
    1798131  NM_073902.31  NP_506303.11 


    ENSEMBL Gene Tree for AMY2B (if available)
    TreeFam Gene Tree for AMY2B (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for AMY2B gene
    AMY1A2  AMY2A2  AMY1C2  AMY1B2  
    4 SIMAP similar genes for AMY2B using alignment to 4 protein entries:     AMY2B_HUMAN (see all proteins):
    AMY1A    AMY1B    AMY1C    AMY2A

    AMY2B for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for AMY2B (see all 439)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs721579731,2
    C--102172918(+) GTATG-/TATA  
            
    TATAT
    1 -- int10--------
    rs1920690691,2
    --104098549(+) CCATAA/GACCTG 1 -- int10--------
    rs1180520301,2
    C,F--104098574(+) GGGTTC/TGTTTT 1 -- int11Minor allele frequency- T:0.03EA 120
    rs1835354111,2
    --104098612(+) GTAACA/GGTAGG 1 -- int10--------
    rs729992901,2
    C,F--104098650(+) TGTCGG/ATAGTT 1 -- int13Minor allele frequency- A:0.11WA CSA 122
    rs1875907241,2
    --104098668(+) TAGGAA/GCATGT 1 -- int10--------
    rs1436987481,2
    --104098736(+) AGTCAC/TGAAGG 1 -- int10--------
    rs2014342901,2
    --104098800(+) ACATA-/CCTCTT 1 -- int10--------
    rs1996409791,2
    --104098802(+) CATAC-/TC    
       TTAGG
    CAATC
    1 -- int10--------
    rs1900589311,2
    --104098894(+) CTGAAA/GAAGTA 1 -- int10--------

    HapMap Linkage Disequilibrium report for AMY2B (104096437 - 104122156 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for AMY2B (see all 28):    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv871791CNV Loss21882294
    nsv830904CNV Loss17160897
    dgv300n71CNV Loss21882294
    dgv297n71CNV Gain21882294
    nsv523177CNV Gain19592680
    esv33927CNV Gain17666407
    nsv511132CNV Gain21212237
    dgv3n64CNV Gain17921354
    nsv870628CNV Gain21882294
    dgv299n71CNV Gain21882294

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 104660    OMIM disorders: --

    2 diseases for AMY2B:    
    About MalaCards
    pancreatitis    thyroiditis


    AMY2B for disorders           About GeneDecksing

    1 Novoseek inferred disease relationship for AMY2B gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    carcinoid 38.6 2 2401405 (2)

    Genetic Association Database (GAD): AMY2B
    Human Genome Epidemiology (HuGE) Navigator: AMY2B (3 documents)

    Export disorders for AMY2B gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

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    PubMed articles for AMY2B gene, integrated from 10 sources (see all 45):
    (articles sorted by number of sources associating them with AMY2B)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification of the characteristic amino-acid sequence for human alpha-amylase encoded by the AMY2B gene. (PubMed id 8268204)1, 2, 3 Omichi K. and Hase S. (Biochim. Biophys. Acta 1993)
    2. Cloning and characterization of a third type of human alpha-amylase gene, AMY2B. (PubMed id 2401405)1, 2, 9 Yokouchi H....Matsubara K. (Gene 1990)
    3. On the genetic polymorphism of the serum alpha-amylase in the population of the south western Bulgaria (second communication). (PubMed id 16152770)1, 4 Baltova S.D. (Folia Med (Plovdiv) 2005)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    6. A novel type of human alpha-amylase produced in lung carcinoid tumor. (PubMed id 2701942)1, 2 Tomita N.... Matsubara K. (Gene 1989)
    7. Concerted evolution of human amylase genes. (PubMed id 2452973)1, 2 Gumucio D.L....Meisler M.H. (Mol. Cell. Biol. 1988)
    8. Human pancreatic amylase is encoded by two different genes. (PubMed id 3260028)1, 2 Groot P.C.... Frants R.R. (Nucleic Acids Res. 1988)
    9. alpha-Amylase expressed in human liver is encoded by the AMY-2B gene identified in tumorous tissues. (PubMed id 11408008)1, 9 Koyama I....Komoda T. ( international journal of clinical chemistry 2001)
    10. Detection of human urinary alpha-amylase encoded by the AMY2B gene using a fluorogenic substrate, FG5P. (PubMed id 1429515)1, 9 Omichi K. and Hase S. (J. Biochem. 1992)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

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    Entrez Gene: 280 HGNC: 478 AceView: FLJ25070 Ensembl:ENSG00000240038 euGenes: HUgn280
    ECgene: AMY2B Kegg: 280 H-InvDB: AMY2B

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for AMY2B Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for AMY2B gene:
    Search GeneIP for patents involving AMY2B

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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