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Aliases for AMY2B Gene

Aliases for AMY2B Gene

  • Amylase, Alpha 2B (Pancreatic) 2 3 5
  • 1,4-Alpha-D-Glucan Glucanohydrolase 2B 3 4
  • Carcinoid Alpha-Amylase 3 4
  • EC 3.2.1.1 4 56
  • Amylase, Alpha 2B; Pancreatic 2
  • Alpha-Amylase 2B 3
  • Glycogenase 3
  • AMY2 3
  • AMY3 3
  • HXA 3

External Ids for AMY2B Gene

Previous HGNC Symbols for AMY2B Gene

  • AMY2

Previous GeneCards Identifiers for AMY2B Gene

  • GC01P104761
  • GC01P103104
  • GC01P103251
  • GC01P103424
  • GC01P103426
  • GC01P103781
  • GC01P103809
  • GC01P103897
  • GC01P104096
  • GC01P102153

Summaries for AMY2B Gene

Entrez Gene Summary for AMY2B Gene

  • Amylases are secreted proteins that hydrolyze 1,4-alpha-glucoside bonds in oligosaccharides and polysaccharides, and thus catalyze the first step in digestion of dietary starch and glycogen. The human genome has a cluster of several amylase genes that are expressed at high levels in either salivary gland or pancreas. This gene encodes an amylase isoenzyme produced by the pancreas. [provided by RefSeq, Jun 2013]

GeneCards Summary for AMY2B Gene

AMY2B (Amylase, Alpha 2B (Pancreatic)) is a Protein Coding gene. Among its related pathways are Glycosaminoglycan metabolism and Pancreatic secretion. Gene Ontology (GO) annotations related to this gene include cation binding and alpha-amylase activity. An important paralog of this gene is AMY2A.

Gene Wiki entry for AMY2B Gene

Additional gene information for AMY2B Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for AMY2B Gene

Genomics for AMY2B Gene

GeneHancer (GH) Regulatory Elements for AMY2B Gene

Promoters and enhancers for AMY2B Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01I103554 Promoter 0.5 EPDnew 550.8 +0.9 879 0.1 AMY2B ACTG1P4 RNPC3
GH01I103570 Promoter 0.5 EPDnew 550.4 +16.8 16812 0.1 ACTG1P4 AMY2B GC01P103577
GH01I103524 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 23.4 -27.8 -27758 3.1 PKNOX1 ATF1 SMAD1 ARID4B SIN3A DMAP1 BRCA1 YY1 POLR2B ZNF143 LOC101928436 RNPC3 AMY2B GC01M103512
GH01I103561 Enhancer 0.7 Ensembl ENCODE 23.5 +8.1 8086 1.4 FOXA2 RXRA ZBTB33 RBBP5 HNF4A RUNX3 FOXA1 AMY2B RN7SKP285 RNPC3 LOC101928436 ACTG1P4
GH01I103515 Enhancer 0.4 ENCODE 17.9 -37.3 -37264 1.5 JUND JUNB AMY2B COL11A1 GC01M103511 LOC101928436 RN7SKP285 GC01M103512
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around AMY2B on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the AMY2B gene promoter:

Genomic Locations for AMY2B Gene

Genomic Locations for AMY2B Gene
chr1:103,553,815-103,579,534
(GRCh38/hg38)
Size:
25,720 bases
Orientation:
Plus strand
chr1:104,096,437-104,122,156
(GRCh37/hg19)

Genomic View for AMY2B Gene

Genes around AMY2B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
AMY2B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for AMY2B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for AMY2B Gene

Proteins for AMY2B Gene

  • Protein details for AMY2B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P19961-AMY2B_HUMAN
    Recommended name:
    Alpha-amylase 2B
    Protein Accession:
    P19961
    Secondary Accessions:
    • B3KTI1
    • B3KXB7
    • D3DT76
    • Q9UBH3

    Protein attributes for AMY2B Gene

    Size:
    511 amino acids
    Molecular mass:
    57710 Da
    Cofactor:
    Name=Ca(2+); Xref=ChEBI:CHEBI:29108;
    Cofactor:
    Name=chloride; Xref=ChEBI:CHEBI:17996;
    Quaternary structure:
    • Monomer.

    Alternative splice isoforms for AMY2B Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for AMY2B Gene

Selected DME Specific Peptides for AMY2B Gene

P19961:
  • RVTEFKYGAKLGTVIRKWNGEKM
  • GVRIYVD
  • AHFSISNS
  • DNHDNQR
  • GEKMSYLKNWGEGWG
  • RPWWERYQP
  • CEHRWRQ
  • GFCWAQY
  • FMLAHPYG
  • GLLDLALEKDYVR
  • FRNVVDG
  • LDKLHNLN
  • AEDPFIAIH
  • LPAGTYCDV
  • SILTFWDAR
  • YMNHLID
  • QEVIDLGGE
  • IVFNNDDW
  • YCDVISG
  • SNQVAFGRG
  • GFIVFNN
  • PAVPYSGWDFNDGKC
  • QVRDCRL

Post-translational modifications for AMY2B Gene

No Post-translational modifications

Other Protein References for AMY2B Gene

Domains & Families for AMY2B Gene

Gene Families for AMY2B Gene

Human Protein Atlas (HPA):
  • Enzymes
  • Plasma proteins
  • Predicted secreted proteins

Suggested Antigen Peptide Sequences for AMY2B Gene

Graphical View of Domain Structure for InterPro Entry

P19961

UniProtKB/Swiss-Prot:

AMY2B_HUMAN :
  • Belongs to the glycosyl hydrolase 13 family.
Family:
  • Belongs to the glycosyl hydrolase 13 family.
genes like me logo Genes that share domains with AMY2B: view

Function for AMY2B Gene

Molecular function for AMY2B Gene

GENATLAS Biochemistry:
amylase,alpha-2B,liver,pancreas,see AMY@
UniProtKB/Swiss-Prot CatalyticActivity:
Endohydrolysis of (1->4)-alpha-D-glucosidic linkages in polysaccharides containing three or more (1->4)-alpha-linked D-glucose units.

Enzyme Numbers (IUBMB) for AMY2B Gene

Gene Ontology (GO) - Molecular Function for AMY2B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004556 alpha-amylase activity TAS,IEA --
GO:0016787 hydrolase activity IEA --
GO:0016798 hydrolase activity, acting on glycosyl bonds IEA --
GO:0043169 cation binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with AMY2B: view
genes like me logo Genes that share phenotypes with AMY2B: view

No data available for Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for AMY2B Gene

Localization for AMY2B Gene

Subcellular locations from UniProtKB/Swiss-Prot for AMY2B Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for AMY2B gene
Compartment Confidence
extracellular 5
mitochondrion 1
peroxisome 1
nucleus 1
endoplasmic reticulum 1
cytosol 1
lysosome 1

Gene Ontology (GO) - Cellular Components for AMY2B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0070062 extracellular exosome HDA,IDA 23533145
genes like me logo Genes that share ontologies with AMY2B: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for AMY2B Gene

Pathways & Interactions for AMY2B Gene

genes like me logo Genes that share pathways with AMY2B: view

Pathways by source for AMY2B Gene

Gene Ontology (GO) - Biological Process for AMY2B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005975 carbohydrate metabolic process NAS,IEA --
GO:0007586 digestion TAS 2401405
GO:0008152 metabolic process IEA --
genes like me logo Genes that share ontologies with AMY2B: view

No data available for SIGNOR curated interactions for AMY2B Gene

Drugs & Compounds for AMY2B Gene

(13) Drugs for AMY2B Gene - From: DrugBank, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Pidolic Acid Approved, Experimental, Investigational Pharma Target 0
calcium Approved Nutra 0
Water Approved Pharma 0
maltose Experimental, Investigational Pharma Target 0
1,4-dithio-alpha-D-glucopyranose Experimental Pharma Target 0

(6) Additional Compounds for AMY2B Gene - From: Novoseek and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Chloride ion
  • Bertholite
  • Chloor
  • Chlor
  • Chlore
  • Chloride
16887-00-6
Dextrin
  • British gum
  • Caloreen
  • Corn dextrin
  • Crystal gum
  • Dextrid
9004-53-9
Maltotriose
  • 4-O-(4-O-Hexopyranosylhexopyranosyl)hexose
  • Amylotriose
  • D-(+)-Maltotriose
  • delta-(+)-Maltotriose
  • Maltotriose
1109-28-0
genes like me logo Genes that share compounds with AMY2B: view

Transcripts for AMY2B Gene

Unigene Clusters for AMY2B Gene

Amylase, alpha 2B (pancreatic):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for AMY2B Gene

No ASD Table

Relevant External Links for AMY2B Gene

GeneLoc Exon Structure for
AMY2B
ECgene alternative splicing isoforms for
AMY2B

Expression for AMY2B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for AMY2B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for AMY2B Gene

This gene is overexpressed in Pancreas (x37.3).

Protein differential expression in normal tissues from HIPED for AMY2B Gene

This gene is overexpressed in Saliva (29.0), Pancreatic juice (27.7), and Urine (10.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for AMY2B Gene



Protein tissue co-expression partners for AMY2B Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of AMY2B Gene:

AMY2B

SOURCE GeneReport for Unigene cluster for AMY2B Gene:

Hs.484588

Evidence on tissue expression from TISSUES for AMY2B Gene

  • Pancreas(4.8)
  • Nervous system(4.4)
  • Kidney(4.3)
  • Urine(4.2)
genes like me logo Genes that share expression patterns with AMY2B: view

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for AMY2B Gene

Orthologs for AMY2B Gene

This gene was present in the common ancestor of animals.

Orthologs for AMY2B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia AMY2B 33 34
  • 99.61 (n)
dog
(Canis familiaris)
Mammalia -- 34
  • 91 (a)
ManyToMany
-- 34
  • 91 (a)
ManyToMany
-- 34
  • 91 (a)
ManyToMany
-- 34
  • 90 (a)
ManyToMany
-- 34
  • 89 (a)
ManyToMany
-- 34
  • 88 (a)
ManyToMany
cow
(Bos Taurus)
Mammalia -- 34
  • 86 (a)
ManyToMany
AMY2B 34
  • 86 (a)
ManyToMany
oppossum
(Monodelphis domestica)
Mammalia -- 34
  • 85 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Amy1 34
  • 85 (a)
ManyToMany
Amy2a2 34
  • 85 (a)
ManyToMany
Amy2a3 34
  • 85 (a)
ManyToMany
Amy2a4 34
  • 85 (a)
ManyToMany
Amy2a5 33 16 34
  • 84.51 (n)
Amy2a1 34
  • 82 (a)
ManyToMany
rat
(Rattus norvegicus)
Mammalia LOC100911494 33
  • 84.25 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 84 (a)
OneToMany
chicken
(Gallus gallus)
Aves AMY2A 34
  • 82 (a)
ManyToMany
AMY1A 34
  • 79 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia -- 34
  • 80 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia amy2a 33
  • 73.59 (n)
Str.5812 33
African clawed frog
(Xenopus laevis)
Amphibia MGC64337 33
zebrafish
(Danio rerio)
Actinopterygii amy2a 33 34
  • 69.21 (n)
zgc:92137 34
  • 69 (a)
ManyToMany
zgc:66313 34
  • 68 (a)
ManyToMany
fruit fly
(Drosophila melanogaster)
Insecta Amy-p 35 33 34
  • 55.81 (n)
Amy-d 35 34
  • 51 (a)
Amyrel 35 34
  • 48 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002318 33
  • 52.22 (n)
worm
(Caenorhabditis elegans)
Secernentea CELE_C50B6.7 33
  • 55.33 (n)
C50B6.7 35 34
  • 44 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 54 (a)
OneToMany
Species where no ortholog for AMY2B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for AMY2B Gene

ENSEMBL:
Gene Tree for AMY2B (if available)
TreeFam:
Gene Tree for AMY2B (if available)

Paralogs for AMY2B Gene

Paralogs for AMY2B Gene

(4) SIMAP similar genes for AMY2B Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with AMY2B: view

Variants for AMY2B Gene

Sequence variations from dbSNP and Humsavar for AMY2B Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
rs1000077186 -- 103,575,014(+) GTGTGTGTGTGT/GTGTGTGTGT intron_variant
rs1000260855 -- 103,569,589(+) G/C intron_variant
rs1000381755 -- 103,557,418(+) A/G/T intron_variant
rs1000515817 -- 103,564,242(+) A/C intron_variant
rs1000549551 -- 103,574,810(+) T/C intron_variant

Structural Variations from Database of Genomic Variants (DGV) for AMY2B Gene

Variant ID Type Subtype PubMed ID
dgv14n21 CNV gain 19592680
dgv213n100 CNV gain 25217958
dgv214n100 CNV gain 25217958
dgv215n100 CNV gain 25217958
dgv216n100 CNV gain 25217958
dgv217n100 CNV gain 25217958
dgv218n100 CNV gain 25217958
dgv2e203 CNV gain+loss 21179565
dgv35e214 CNV gain 21293372
dgv392n54 CNV gain 21841781
dgv393n54 CNV gain 21841781
dgv394n54 CNV gain 21841781
dgv395n54 CNV gain 21841781
dgv396n54 CNV gain 21841781
dgv397n54 CNV loss 21841781
dgv398n54 CNV gain 21841781
dgv399n54 CNV gain 21841781
dgv3n64 CNV gain 17921354
dgv68e212 CNV gain 25503493
dgv69e212 CNV gain 25503493
esv1004547 CNV gain 20482838
esv23292 CNV gain+loss 19812545
esv2758954 CNV gain+loss 17122850
esv33927 CNV gain 17666407
esv3583026 CNV gain 25503493
esv3893856 CNV gain+loss 25118596
nsv1012949 CNV gain 25217958
nsv10428 CNV gain+loss 18304495
nsv1152675 CNV duplication 26484159
nsv1161038 CNV duplication 26073780
nsv428157 CNV gain+loss 18775914
nsv442937 CNV gain 18776908
nsv511132 CNV gain 21212237
nsv514909 CNV gain 21397061
nsv517215 CNV gain+loss 19592680
nsv523177 CNV gain 19592680
nsv526367 CNV gain 19592680
nsv546955 CNV loss 21841781
nsv546976 CNV gain 21841781
nsv546979 CNV gain 21841781
nsv823686 CNV gain 20364138
nsv830904 CNV loss 17160897
nsv830915 CNV gain+loss 17160897
nsv946105 CNV duplication 23825009
nsv946106 CNV duplication 23825009

Variation tolerance for AMY2B Gene

Residual Variation Intolerance Score: 92.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.79; 58.19% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for AMY2B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
AMY2B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for AMY2B Gene

Disorders for AMY2B Gene

Additional Disease Information for AMY2B

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for AMY2B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for AMY2B Gene

Publications for AMY2B Gene

  1. Identification of the characteristic amino-acid sequence for human alpha-amylase encoded by the AMY2B gene. (PMID: 8268204) Omichi K … Hase S (Biochimica et biophysica acta 1993) 2 3 4 58
  2. Cloning and characterization of a third type of human alpha-amylase gene, AMY2B. (PMID: 2401405) Yokouchi H … Matsubara K (Gene 1990) 3 4 22 58
  3. On the genetic polymorphism of the serum alpha-amylase in the population of the south western Bulgaria (second communication). (PMID: 16152770) Baltova SD (Folia medica 2005) 3 44 58
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58

Products for AMY2B Gene

Sources for AMY2B Gene

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