Free for academic non-profit institutions. Other users need a Commercial license

Aliases for AMY2B Gene

Aliases for AMY2B Gene

  • Amylase, Alpha 2B (Pancreatic) 2 3 5
  • 1,4-Alpha-D-Glucan Glucanohydrolase 2B 3 4
  • Carcinoid Alpha-Amylase 3 4
  • EC 4 61
  • Amylase, Alpha 2B; Pancreatic 2
  • Alpha-Amylase 2B 3
  • Glycogenase 3
  • AMY2 3
  • AMY3 3
  • HXA 3

External Ids for AMY2B Gene

Previous HGNC Symbols for AMY2B Gene

  • AMY2

Previous GeneCards Identifiers for AMY2B Gene

  • GC01P104761
  • GC01P103104
  • GC01P103251
  • GC01P103424
  • GC01P103426
  • GC01P103781
  • GC01P103809
  • GC01P103897
  • GC01P104096
  • GC01P102153

Summaries for AMY2B Gene

Entrez Gene Summary for AMY2B Gene

  • Amylases are secreted proteins that hydrolyze 1,4-alpha-glucoside bonds in oligosaccharides and polysaccharides, and thus catalyze the first step in digestion of dietary starch and glycogen. The human genome has a cluster of several amylase genes that are expressed at high levels in either salivary gland or pancreas. This gene encodes an amylase isoenzyme produced by the pancreas. [provided by RefSeq, Jun 2013]

GeneCards Summary for AMY2B Gene

AMY2B (Amylase, Alpha 2B (Pancreatic)) is a Protein Coding gene. Among its related pathways are Metabolism and Digestion of dietary carbohydrate. GO annotations related to this gene include cation binding and alpha-amylase activity. An important paralog of this gene is AMY2A.

Gene Wiki entry for AMY2B Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for AMY2B Gene

Genomics for AMY2B Gene

Regulatory Elements for AMY2B Gene

Enhancers for AMY2B Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01F103524 1 ENCODE 23.4 -28.1 -28052 2.5 PKNOX1 ATF1 CREB3L1 ARID4B SIN3A DMAP1 BRCA1 YY1 ZNF143 ZNF263 AMY2B RNPC3 GC01M103512
GH01F103515 0.4 ENCODE 17.9 -37.3 -37265 1.5 JUND JUNB AMY2B COL11A1 GC01M103511 RN7SKP285
GH01F103562 0.5 ENCODE 0.4 +8.4 8399 0.2 ZNF316 RAD51 RBBP5 ZBTB33 RN7SKP285 RNPC3 LOC101928436 ACTG1P4 AMY2B
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around AMY2B on UCSC Golden Path with GeneCards custom track

Genomic Location for AMY2B Gene

103,553,815 bp from pter
103,579,534 bp from pter
25,720 bases
Plus strand

Genomic View for AMY2B Gene

Genes around AMY2B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
AMY2B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for AMY2B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for AMY2B Gene

Proteins for AMY2B Gene

  • Protein details for AMY2B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Alpha-amylase 2B
    Protein Accession:
    Secondary Accessions:
    • B3KTI1
    • B3KXB7
    • D3DT76
    • Q9UBH3

    Protein attributes for AMY2B Gene

    511 amino acids
    Molecular mass:
    57710 Da
    Name=Ca(2+); Xref=ChEBI:CHEBI:29108;
    Name=chloride; Xref=ChEBI:CHEBI:17996;
    Quaternary structure:
    • Monomer.

    Alternative splice isoforms for AMY2B Gene


neXtProt entry for AMY2B Gene

Selected DME Specific Peptides for AMY2B Gene


Post-translational modifications for AMY2B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for AMY2B Gene

Domains & Families for AMY2B Gene

Suggested Antigen Peptide Sequences for AMY2B Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the glycosyl hydrolase 13 family.
  • Belongs to the glycosyl hydrolase 13 family.
genes like me logo Genes that share domains with AMY2B: view

No data available for Gene Families for AMY2B Gene

Function for AMY2B Gene

Molecular function for AMY2B Gene

GENATLAS Biochemistry:
amylase,alpha-2B,liver,pancreas,see AMY@
UniProtKB/Swiss-Prot CatalyticActivity:
Endohydrolysis of (1->4)-alpha-D-glucosidic linkages in polysaccharides containing three or more (1->4)-alpha-linked D-glucose units.

Enzyme Numbers (IUBMB) for AMY2B Gene

Gene Ontology (GO) - Molecular Function for AMY2B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004556 alpha-amylase activity IEA --
GO:0016787 hydrolase activity IEA --
GO:0016798 hydrolase activity, acting on glycosyl bonds IEA --
GO:0043169 cation binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with AMY2B: view
genes like me logo Genes that share phenotypes with AMY2B: view

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for AMY2B Gene

Localization for AMY2B Gene

Subcellular locations from UniProtKB/Swiss-Prot for AMY2B Gene


Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for AMY2B gene
Compartment Confidence
extracellular 5
mitochondrion 1
peroxisome 1
nucleus 1
endoplasmic reticulum 1
cytosol 1
lysosome 1

Gene Ontology (GO) - Cellular Components for AMY2B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0070062 extracellular exosome IDA 23533145
genes like me logo Genes that share ontologies with AMY2B: view

Pathways & Interactions for AMY2B Gene

genes like me logo Genes that share pathways with AMY2B: view

Pathways by source for AMY2B Gene

Interacting Proteins for AMY2B Gene

Gene Ontology (GO) - Biological Process for AMY2B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005975 carbohydrate metabolic process IEA --
GO:0007586 digestion TAS 2401405
GO:0008152 metabolic process IEA --
genes like me logo Genes that share ontologies with AMY2B: view

No data available for SIGNOR curated interactions for AMY2B Gene

Drugs & Compounds for AMY2B Gene

(12) Drugs for AMY2B Gene - From: DrugBank, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Water Approved Pharma 0
maltose Experimental Pharma Target 0
Pyroglutamic acid Experimental Pharma Target 0
1,4-Dithio-Alpha-D-Mannose Experimental Pharma Target 0
4-Methylthio-Alpha-D-Mannose Experimental Pharma Target 0

(7) Additional Compounds for AMY2B Gene - From: HMDB and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Chloride ion
  • Bertholite
  • Chloor
  • Chlor
  • Chlore
  • Chloride
  • British gum
  • Caloreen
  • Corn dextrin
  • Crystal gum
  • Dextrid
  • (+)-mannose
  • (+-)-mannose
  • Carubinose
  • D(+)-Mannose
  • D-Mannopyranose
  • 4-O-(4-O-Hexopyranosylhexopyranosyl)hexose
  • Amylotriose
  • D-(+)-Maltotriose
  • delta-(+)-Maltotriose
  • Maltotriose
genes like me logo Genes that share compounds with AMY2B: view

Transcripts for AMY2B Gene

Unigene Clusters for AMY2B Gene

Amylase, alpha 2B (pancreatic):
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for AMY2B Gene

No ASD Table

Relevant External Links for AMY2B Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for AMY2B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for AMY2B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for AMY2B Gene

This gene is overexpressed in Pancreas (x37.3).

Protein differential expression in normal tissues from HIPED for AMY2B Gene

This gene is overexpressed in Saliva (29.0), Pancreatic juice (27.7), and Urine (10.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for AMY2B Gene

Protein tissue co-expression partners for AMY2B Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of AMY2B Gene:


SOURCE GeneReport for Unigene cluster for AMY2B Gene:

genes like me logo Genes that share expression patterns with AMY2B: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt for AMY2B Gene

Orthologs for AMY2B Gene

This gene was present in the common ancestor of animals.

Orthologs for AMY2B Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia AMY2B 34 35
  • 99.61 (n)
(Canis familiaris)
Mammalia -- 35
  • 91 (a)
-- 35
  • 91 (a)
-- 35
  • 91 (a)
-- 35
  • 90 (a)
-- 35
  • 89 (a)
-- 35
  • 88 (a)
(Bos Taurus)
Mammalia -- 35
  • 86 (a)
AMY2B 35
  • 86 (a)
(Monodelphis domestica)
Mammalia -- 35
  • 85 (a)
(Mus musculus)
Mammalia Amy1 35
  • 85 (a)
Amy2a2 35
  • 85 (a)
Amy2a3 35
  • 85 (a)
Amy2a4 35
  • 85 (a)
Amy2a5 34 16 35
  • 84.51 (n)
Amy2a1 35
  • 82 (a)
(Rattus norvegicus)
Mammalia LOC100911494 34
  • 84.25 (n)
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 84 (a)
(Gallus gallus)
Aves AMY2A 35
  • 82 (a)
AMY1A 35
  • 79 (a)
(Anolis carolinensis)
Reptilia -- 35
  • 80 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia amy2a 34
  • 73.59 (n)
Str.5812 34
African clawed frog
(Xenopus laevis)
Amphibia MGC64337 34
(Danio rerio)
Actinopterygii amy2a 34 35
  • 69.21 (n)
zgc:92137 35
  • 69 (a)
zgc:66313 35
  • 68 (a)
fruit fly
(Drosophila melanogaster)
Insecta Amy-p 36 34 35
  • 55.81 (n)
Amy-d 36 35
  • 51 (a)
Amyrel 36 35
  • 48 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002318 34
  • 52.22 (n)
(Caenorhabditis elegans)
Secernentea CELE_C50B6.7 34
  • 55.33 (n)
C50B6.7 36 35
  • 44 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 54 (a)
Species where no ortholog for AMY2B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for AMY2B Gene

Gene Tree for AMY2B (if available)
Gene Tree for AMY2B (if available)

Paralogs for AMY2B Gene

Paralogs for AMY2B Gene

(4) SIMAP similar genes for AMY2B Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with AMY2B: view

Variants for AMY2B Gene

Sequence variations from dbSNP and Humsavar for AMY2B Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs10159229 -- 103,567,336(+) GCTGG(C/G)GGAAG intron-variant
rs1058612 -- 103,555,093(+) TGACC(A/C)CCTGG utr-variant-3-prime, utr-variant-5-prime
rs10609513 -- 103,565,659(+) AACCC(-/CAGT)CAAAC intron-variant
rs10754 -- 103,555,063(-) AGAAA(A/G)CACTT utr-variant-3-prime, utr-variant-5-prime
rs111586902 -- 103,577,973(+) ATAGA(C/G)ATCAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for AMY2B Gene

Variant ID Type Subtype PubMed ID
nsv946106 CNV duplication 23825009
nsv946105 CNV duplication 23825009
nsv830915 CNV gain+loss 17160897
nsv830904 CNV loss 17160897
nsv823686 CNV gain 20364138
nsv546979 CNV gain 21841781
nsv546976 CNV gain 21841781
nsv546955 CNV loss 21841781
nsv526367 CNV gain 19592680
nsv523177 CNV gain 19592680
nsv517215 CNV gain+loss 19592680
nsv514909 CNV gain 21397061
nsv511132 CNV gain 21212237
nsv442937 CNV gain 18776908
nsv428157 CNV gain+loss 18775914
nsv1161038 CNV duplication 26073780
nsv1152675 CNV duplication 26484159
nsv10428 CNV gain+loss 18304495
nsv1012949 CNV gain 25217958
esv3893856 CNV gain+loss 25118596
esv3583026 CNV gain 25503493
esv33927 CNV gain 17666407
esv2758954 CNV gain+loss 17122850
esv23292 CNV gain+loss 19812545
esv1004547 CNV gain 20482838
dgv69e212 CNV gain 25503493
dgv68e212 CNV gain 25503493
dgv3n64 CNV gain 17921354
dgv399n54 CNV gain 21841781
dgv398n54 CNV gain 21841781
dgv397n54 CNV loss 21841781
dgv396n54 CNV gain 21841781
dgv395n54 CNV gain 21841781
dgv394n54 CNV gain 21841781
dgv393n54 CNV gain 21841781
dgv392n54 CNV gain 21841781
dgv35e214 CNV gain 21293372
dgv2e203 CNV gain+loss 21179565
dgv218n100 CNV gain 25217958
dgv217n100 CNV gain 25217958
dgv216n100 CNV gain 25217958
dgv215n100 CNV gain 25217958
dgv214n100 CNV gain 25217958
dgv213n100 CNV gain 25217958
dgv14n21 CNV gain 19592680

Variation tolerance for AMY2B Gene

Residual Variation Intolerance Score: 92.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.79; 58.19% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for AMY2B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for AMY2B Gene

Disorders for AMY2B Gene

Relevant External Links for AMY2B

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for AMY2B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for AMY2B Gene

Publications for AMY2B Gene

  1. Identification of the characteristic amino-acid sequence for human alpha-amylase encoded by the AMY2B gene. (PMID: 8268204) Omichi K. … Hase S. (Biochim. Biophys. Acta 1993) 2 3 4 64
  2. Cloning and characterization of a third type of human alpha-amylase gene, AMY2B. (PMID: 2401405) Yokouchi H. … Matsubara K. (Gene 1990) 3 4 22 64
  3. On the genetic polymorphism of the serum alpha-amylase in the population of the south western Bulgaria (second communication). (PMID: 16152770) Baltova S.D. (Folia Med (Plovdiv) 2005) 3 46 64
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64

Products for AMY2B Gene

Sources for AMY2B Gene

Loading form....