AMY2B Gene
protein-coding GIFtS: 57
GCID: GC01P104096
|
|
amylase, alpha 2B (pancreatic)(Previous names: amylase, alpha 2B; pancreatic )
(Previous symbol: AMY2)
| |
Aliases
for AMY2B gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Amylase, Alpha 2B (Pancreatic)1 2 | | Amylase, Alpha 2B; Pancreatic1 | | AMY21 2 | | Alpha-Amylase 2B2 | | Carcinoid Alpha-Amylase2 3 | | Alpha-Amylase Carcinoid2 | | 1,4-Alpha-D-Glucan Glucanohydrolase 2B2 3 | | Glycogenase1 | | EC 3.2.1.13 8 | | |
Export aliases for AMY2B gene to outside databasesPrevious GC identifers: GC01P104761 GC01P103104 GC01P103251 GC01P103424 GC01P103426 GC01P103781 GC01P103809 GC01P103897 GC01P102153 |
Summaries
for AMY2B gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for AMY2B:
Amylases are secreted proteins that hydrolyze 1,4-alpha-glucoside bonds in oligosaccharides and polysaccharides, andthus catalyze the first step in digestion of dietary starch and glycogen. The human genome has a cluster of severalamylase genes that are expressed at high levels in either salivary gland or pancreas. This gene encodes an amylaseisoenzyme produced by the pancreas. (provided by RefSeq, Jul 2008)
Gene Wiki entry for AMY2B
|
Genomic Views
for AMY2B gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000001.10 NC_018912.1 NT_032977.9
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the AMY2B gene promoter:
FOXF2 Nkx2-2 FOXD1 RelA Evi-1 FAC1 c-Rel FOXC1 FOXO4 IRF-7A
Other transcription factors
Search SABiosciences Chromatin IP Primers for AMY2B
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat AMY2B |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 1p21 Ensembl cytogenetic band: 1p21.1 HGNC cytogenetic band: 1p21AMY2B Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 1 GeneLoc Exon Structure GeneLoc location for GC01P104096: view genomic region
(about GC identifiers)
Start:
|
104,096,437 bp from pter |
End:
|
104,122,156 bp from pter |
Size:
|
25,720 bases |
Orientation:
|
plus strand |
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Proteins
for AMY2B gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: AMY2B_HUMAN, P19961 (See
protein sequence)Recommended Name: Alpha-amylase 2B precursor Size: 511 amino acids; 57710 Da
Cofactor: Binds 1 calcium ion per subunit (By similarity)
Cofactor: Binds 1 chloride ion per subunit (By similarity)
Subunit: Monomer (By similarity)
Subcellular location: Secreted (By similarity)
Secondary accessions: B3KXB7 D3DT76 Q9UBH3Explore the universe of human proteins at neXtProt for AMY2B: NX_P19961
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_P19961
4/23 DME Specific Peptides for AMY2B (P19961) (see all 23)
AMY2B Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_066188.1
ENSEMBL proteins: ENSP00000433347 ENSP00000354610 ENSP00000391423 ENSP00000401627 Reactome Protein details: P19961
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005576 | extracellular region |
IEA | -- |
AMY2B for ontologies About GeneDecksing
AMY2B Antibody Products:
Assay Products for AMY2B: |
Protein
Domains /
Families
for AMY2B gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
AMY2B for domains About GeneDecksing
5/8 InterPro domains/families (see all 8):Graphical View of Domain Structure for InterPro Entry P19961ProtoNet protein and cluster: P19961 3 Blocks protein families: IPB006046 Alpha-amylase signature IPB006048 Alpha amylase IPB006589 Alpha amylase
UniProtKB/Swiss-Prot: AMY2B_HUMAN, P19961Similarity: Belongs to the glycosyl hydrolase 13 family |
Function
for AMY2B gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: AMY2B_HUMAN, P19961Catalytic activity: Endohydrolysis of (1->4)-alpha-D-glucosidic linkages in polysaccharides containing three or more(1->4)-alpha-linked D-glucose units Genatlas biochemistry entry for AMY2B:amylase,alpha-2B,liver,pancreas,see AMY@
Enzyme Number (IUBMB): EC 3.2.1.11 2
Clone
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OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for AMY2B
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In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for AMY2B |
Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view): About this table
AMY2B for ontologies About GeneDecksing
|
Pathways & Interactions
for AMY2B gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways - 5/7 super-pathways (see all 7) About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Metabolism | | | 2 | Glucose / Energy Metabolism | | | 3 | Digestion of dietary carbohydrate | | | 4 | Carbohydrate digestion and absorption | | | 5 | Pancreatic secretion | |
Pathway sources
See GeneCards unified pathways
Show all pathways
1 
Cell Signaling Technology (CST) Pathway for AMY2B
3 
Reactome Pathways for AMY2B
4 
Kegg Pathways (Kegg details for AMY2B):
AMY2B for pathways About GeneDecksing
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for AMY2B
2 Interacting proteins for AMY2B (P199613) via UniProtKB, MINT, STRING, and/or I2DAbout this table
Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table
AMY2B for ontologies About GeneDecksing
|
Drugs & Compounds
for AMY2B gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
AMY2B for compounds About GeneDecksing
 Browse Tocris compounds for AMY2B
7 HMDB Compounds for AMY2B About this table
10 DrugBank Compounds for AMY2B About this table
5 Novoseek chemical compound relationships for AMY2B gene About this table
Search CenterWatch for drugs/clinical trials and news about AMY2B
|
Transcripts
for AMY2B gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for AMY2B gene: NM_020978.3 Unigene Cluster for AMY2B: Amylase, alpha 2B (pancreatic) Hs.484588 [show with all ESTs]Unigene Representative Sequence: AK1270477 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000477657(uc001duq.3) ENST00000361355(uc010ouo.2 uc001dus.1)
ENST00000435302 ENST00000453959 ENST00000491397(uc001dur.3) ENST00000462971
ENST00000481821
Clone
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OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for AMY2B
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: AMY2B (NM_020978) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for AMY2B | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat AMY2B |
Additional cDNA sequence: AK095605.1 AK127047.1 BC011179.1 BC020861.1 DQ786288.1 M24895.1 21 DOTS entries: DT.449355 DT.100892344 DT.315416 DT.121339942 DT.75131378 DT.92447694 DT.92447688 DT.91672656 DT.92447700 DT.75130100 DT.103928 DT.121339866 DT.92061564 DT.95155090 DT.121339838 DT.121339842 DT.121339870 DT.40220827 DT.100892335 DT.100892336 DT.92068068 24/222 AceView cDNA sequences (see all 222): AL832291 CR616713 AK057799 AA679262 M24895 F03754 AL137730 AW583927 NM_017619 AA721649 CA950654 BM670675 AW978322 R96974 BC020861 H45506 CN482148 CA441626 Z44595 F07523 BX497088 BC011179 BX485594 CA447262
GeneLoc Exon Structure
|
Expression
for AMY2B gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| AMY2B expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CTGAATCTAA
About this image
See AMY2B Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for AMY2B
SOURCE GeneReport for Unigene cluster: Hs.484588
SABiosciences Custom PCR Arrays for AMY2B
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for AMY2B
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse / rat AMY2B | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat AMY2B | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat AMY2B | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for AMY2B |
Orthologs
for AMY2B gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for AMY2B gene from 6/17 species (see all 17) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
F1NF53_CHICK6F1NW02_CHICK6 |
amylase, alpha 1A salivary |
82(a)79(a) |
many ↔ manymany ↔ many |
8(38904-43343) 8(11738273-11744621) |
lizard
(Anolis carolinensis) |
Reptilia |
-- |
-- |
78(a) |
1 → many |
4(85539622-85554936) |
African clawed frog
(Xenopus laevis) |
Amphibia |
MGC643372 |
alpha-amylase precursor |
76.79(n) |
|
BC056841.1 |
zebrafish
(Danio rerio) |
Actinopterygii |
amy2a6zgc:921376(see all 3) |
zgc:92137(see all 3) |
74(a)69(a)(see all 3) |
many ↔ manymany ↔ many(see all 3) |
2(15433338-15447555) 17(42998722-43003011) |
fruit fly
(Drosophila melanogaster) |
Insecta |
Amy-p3 |
alpha-amylase |
51(a)
(best of 3) |
|
2 53F12 -- |
worm
(Caenorhabditis elegans) |
Secernentea |
C50B6.73 |
amylase |
44(a) |
|
V(13325025-13327571) -- |
ENSEMBL Gene Tree for AMY2B (if available)
TreeFam Gene Tree for AMY2B (if available) |
Paralogs
for AMY2B gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for AMY2B gene
- AMY1A2 AMY2A2 AMY1C2 AMY1B2
4 SIMAP similar genes for AMY2B using alignment to 4 protein entries: AMY2B_HUMAN (see all proteins):AMY1A AMY1B AMY1C AMY2A
AMY2B for paralogs About GeneDecksing
|
Genomic Variants
for AMY2B gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 1 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for AMY2B (104096437 - 104122156 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 16 variations for AMY2B
15/16 CNVs (see all 16): 6767 69232 48066 31635 9365 3302 30393 74587 69230 48067 48068 74585 84395 37779 69241 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing AMY2B |
|
Disorders
/ Diseases
for AMY2B gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
AMY2B for disorders About GeneDecksing
OMIM gene information: 104660
OMIM disorders: --
3  diseases for AMY2B: About MalaCardspancreatitis carcinoid tumors thyroiditis
1 Novoseek disease relationship for AMY2B gene About this table
| Disease |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| carcinoid |
38.6 |
2 |
2401405 (2) |
Genetic Association Database (GAD): AMY2B
Human Genome Epidemiology (HuGE) Navigator: AMY2B (3 documents)
Export disorders for AMY2B gene to outside databases
|
Publications
for AMY2B gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for AMY2B gene, integrated from 9 sources (see all 40):
(articles sorted by number of sources associating them with AMY2B) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Identification of the characteristic amino-acid sequence for human alpha-amylase encoded by the AMY2B gene. (PubMed id 8268204)1, 2, 3 Omichi K. and Hase S. (1993)
- Cloning and characterization of a third type of human alpha-amylase gene, AMY2B. (PubMed id 2401405)1, 2, 9 Yokouchi H....Matsubara K. (1990)
- On the genetic polymorphism of the serum alpha-amylase in the population of the south western Bulgaria (second communication). (PubMed id 16152770)1, 4 Baltova S.D. (2005)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- A novel type of human alpha-amylase produced in lung carcinoid tumor. (PubMed id 2701942)1, 2 Tomita N.... Matsubara K. (1989)
- Concerted evolution of human amylase genes. (PubMed id 2452973)1, 2 Gumucio D.L....Meisler M.H. (1988)
- Human pancreatic amylase is encoded by two different genes. (PubMed id 3260028)1, 2 Groot P.C.... Frants R.R. (1988)
- alpha-Amylase expressed in human liver is encoded by the AMY-2B gene identified in tumorous tissues. (PubMed id 11408008)1, 9 Koyama I....Komoda T. (2001)
- How many drug targets are there? (PubMed id 17139284)7 Overington J.P....Hopkins A.L. (2006)
|
External Searches for AMY2B gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing AMY2B gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing AMY2B gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing AMY2B gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for AMY2B | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for AMY2B gene:
Search GeneIP for patents involving AMY2B
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for AMY2B gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
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| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for AMY2B |
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