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Aliases for AMY2B Gene

Aliases for AMY2B Gene

  • Amylase, Alpha 2B (Pancreatic) 2 3 5
  • 1,4-Alpha-D-Glucan Glucanohydrolase 2B 3 4
  • Carcinoid Alpha-Amylase 3 4
  • EC 3.2.1.1 4 63
  • Amylase, Alpha 2B; Pancreatic 2
  • Glycogenase 3
  • AMY2 3
  • AMY3 3
  • HXA 3

External Ids for AMY2B Gene

Previous HGNC Symbols for AMY2B Gene

  • AMY2

Previous GeneCards Identifiers for AMY2B Gene

  • GC01P104761
  • GC01P103104
  • GC01P103251
  • GC01P103424
  • GC01P103426
  • GC01P103781
  • GC01P103809
  • GC01P103897
  • GC01P104096
  • GC01P102153

Summaries for AMY2B Gene

Entrez Gene Summary for AMY2B Gene

  • Amylases are secreted proteins that hydrolyze 1,4-alpha-glucoside bonds in oligosaccharides and polysaccharides, and thus catalyze the first step in digestion of dietary starch and glycogen. The human genome has a cluster of several amylase genes that are expressed at high levels in either salivary gland or pancreas. This gene encodes an amylase isoenzyme produced by the pancreas. [provided by RefSeq, Jun 2013]

GeneCards Summary for AMY2B Gene

AMY2B (Amylase, Alpha 2B (Pancreatic)) is a Protein Coding gene. Among its related pathways are Glycosaminoglycan metabolism and Glucose / Energy Metabolism. GO annotations related to this gene include cation binding and alpha-amylase activity. An important paralog of this gene is AMY1C.

Gene Wiki entry for AMY2B Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for AMY2B Gene

Genomics for AMY2B Gene

Regulatory Elements for AMY2B Gene

Enhancers for AMY2B Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around AMY2B on UCSC Golden Path with GeneCards custom track

Genomic Location for AMY2B Gene

Chromosome:
1
Start:
103,553,815 bp from pter
End:
103,579,534 bp from pter
Size:
25,720 bases
Orientation:
Plus strand

Genomic View for AMY2B Gene

Genes around AMY2B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
AMY2B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for AMY2B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for AMY2B Gene

Proteins for AMY2B Gene

  • Protein details for AMY2B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P19961-AMY2B_HUMAN
    Recommended name:
    Alpha-amylase 2B
    Protein Accession:
    P19961
    Secondary Accessions:
    • B3KTI1
    • B3KXB7
    • D3DT76
    • Q9UBH3

    Protein attributes for AMY2B Gene

    Size:
    511 amino acids
    Molecular mass:
    57710 Da
    Cofactor:
    Name=Ca(2+); Xref=ChEBI:CHEBI:29108;
    Cofactor:
    Name=chloride; Xref=ChEBI:CHEBI:17996;
    Quaternary structure:
    • Monomer.

    Alternative splice isoforms for AMY2B Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for AMY2B Gene

Proteomics data for AMY2B Gene at MOPED

Post-translational modifications for AMY2B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for AMY2B Gene

Domains & Families for AMY2B Gene

Suggested Antigen Peptide Sequences for AMY2B Gene

Graphical View of Domain Structure for InterPro Entry

P19961

UniProtKB/Swiss-Prot:

AMY2B_HUMAN :
  • Belongs to the glycosyl hydrolase 13 family.
Family:
  • Belongs to the glycosyl hydrolase 13 family.
genes like me logo Genes that share domains with AMY2B: view

No data available for Gene Families for AMY2B Gene

Function for AMY2B Gene

Molecular function for AMY2B Gene

GENATLAS Biochemistry:
amylase,alpha-2B,liver,pancreas,see AMY@
UniProtKB/Swiss-Prot CatalyticActivity:
Endohydrolysis of (1->4)-alpha-D-glucosidic linkages in polysaccharides containing three or more (1->4)-alpha-linked D-glucose units.

Enzyme Numbers (IUBMB) for AMY2B Gene

Gene Ontology (GO) - Molecular Function for AMY2B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0043169 cation binding IEA --
genes like me logo Genes that share ontologies with AMY2B: view
genes like me logo Genes that share phenotypes with AMY2B: view

Animal Model Products

No data available for Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for AMY2B Gene

Localization for AMY2B Gene

Subcellular locations from UniProtKB/Swiss-Prot for AMY2B Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for AMY2B Gene COMPARTMENTS Subcellular localization image for AMY2B gene
Compartment Confidence
extracellular 5
cytosol 1
endoplasmic reticulum 1
lysosome 1
mitochondrion 1
nucleus 1
peroxisome 1
vacuole 1

No data available for Gene Ontology (GO) - Cellular Components for AMY2B Gene

Pathways & Interactions for AMY2B Gene

genes like me logo Genes that share pathways with AMY2B: view

Pathways by source for AMY2B Gene

Interacting Proteins for AMY2B Gene

Gene Ontology (GO) - Biological Process for AMY2B Gene

None

No data available for SIGNOR curated interactions for AMY2B Gene

Drugs & Compounds for AMY2B Gene

(11) Drugs for AMY2B Gene - From: DrugBank, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Amylotriose Experimental Pharma Target 0
maltose Experimental Pharma Target 0
Pyroglutamic acid Experimental Pharma Target 0
1,4-Dithio-Alpha-D-Mannose Experimental Pharma Target 0
4-Methylthio-Alpha-D-Mannose Experimental Pharma Target 0

(7) Additional Compounds for AMY2B Gene - From: Novoseek and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Chloride ion
  • Bertholite
  • Chloor
  • Chlor
  • Chlore
  • Chloride
16887-00-6
Dextrin
  • British gum
  • Caloreen
  • Corn dextrin
  • Crystal gum
  • Dextrid
9004-53-9
D-Mannose
  • (+)-mannose
  • (+-)-mannose
  • Carubinose
  • D(+)-Mannose
  • D-Mannopyranose
3458-28-4
Water
  • Dihydrogen oxide
  • Steam
7732-18-5
genes like me logo Genes that share compounds with AMY2B: view

Transcripts for AMY2B Gene

Unigene Clusters for AMY2B Gene

Amylase, alpha 2B (pancreatic):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for AMY2B Gene

No ASD Table

Relevant External Links for AMY2B Gene

GeneLoc Exon Structure for
AMY2B
ECgene alternative splicing isoforms for
AMY2B

Expression for AMY2B Gene

mRNA expression in normal human tissues for AMY2B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for AMY2B Gene

This gene is overexpressed in Pancreas (x37.3).

Protein differential expression in normal tissues from HIPED for AMY2B Gene

This gene is overexpressed in Saliva (29.0), Pancreatic juice (27.7), and Urine (10.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for AMY2B Gene



SOURCE GeneReport for Unigene cluster for AMY2B Gene Hs.484588

genes like me logo Genes that share expression patterns with AMY2B: view

Protein tissue co-expression partners for AMY2B Gene

- Elite partner

Primer Products

No data available for mRNA Expression by UniProt/SwissProt for AMY2B Gene

Orthologs for AMY2B Gene

This gene was present in the common ancestor of animals.

Orthologs for AMY2B Gene

Organism Taxonomy Gene Similarity Type Details
mouse
(Mus musculus)
Mammalia Amy2a5 35
  • 84.51 (n)
  • 85.24 (a)
Amy2a5 16
Amy1 36
  • 85 (a)
ManyToMany
Amy2a1 36
  • 82 (a)
ManyToMany
Amy2a2 36
  • 85 (a)
ManyToMany
Amy2a3 36
  • 85 (a)
ManyToMany
Amy2a4 36
  • 85 (a)
ManyToMany
Amy2a5 36
  • 85 (a)
ManyToMany
chimpanzee
(Pan troglodytes)
Mammalia AMY2B 35
  • 99.61 (n)
  • 99.61 (a)
AMY2B 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia LOC100911494 35
  • 84.25 (n)
  • 85.04 (a)
cow
(Bos Taurus)
Mammalia -- 36
  • 86 (a)
ManyToMany
AMY2B 36
  • 86 (a)
ManyToMany
dog
(Canis familiaris)
Mammalia -- 36
  • 88 (a)
ManyToMany
-- 36
  • 91 (a)
ManyToMany
-- 36
  • 89 (a)
ManyToMany
-- 36
  • 90 (a)
ManyToMany
-- 36
  • 91 (a)
ManyToMany
-- 36
  • 91 (a)
ManyToMany
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 85 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 84 (a)
OneToMany
chicken
(Gallus gallus)
Aves AMY1A 36
  • 79 (a)
ManyToMany
AMY2A 36
  • 82 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 80 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia amy2a 35
  • 73.59 (n)
  • 77.45 (a)
Str.5812 35
African clawed frog
(Xenopus laevis)
Amphibia MGC64337 35
zebrafish
(Danio rerio)
Actinopterygii amy2a 35
  • 69.21 (n)
  • 73.39 (a)
amy2a 36
  • 74 (a)
ManyToMany
zgc:66313 36
  • 68 (a)
ManyToMany
zgc:92137 36
  • 69 (a)
ManyToMany
fruit fly
(Drosophila melanogaster)
Insecta Amy-d 37
  • 51 (a)
Amy-p 37
  • 51 (a)
Amyrel 37
  • 48 (a)
Amy-p 35
  • 55.81 (n)
  • 56.15 (a)
Amy-d 36
  • 54 (a)
ManyToMany
Amy-p 36
  • 55 (a)
ManyToMany
Amyrel 36
  • 49 (a)
ManyToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002318 35
  • 52.22 (n)
  • 55.85 (a)
worm
(Caenorhabditis elegans)
Secernentea C50B6.7 37
  • 44 (a)
CELE_C50B6.7 35
  • 55.33 (n)
  • 50.31 (a)
C50B6.7 36
  • 33 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 54 (a)
OneToMany
Species with no ortholog for AMY2B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for AMY2B Gene

ENSEMBL:
Gene Tree for AMY2B (if available)
TreeFam:
Gene Tree for AMY2B (if available)

Paralogs for AMY2B Gene

Paralogs for AMY2B Gene

(4) SIMAP similar genes for AMY2B Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with AMY2B: view

Variants for AMY2B Gene

Sequence variations from dbSNP and Humsavar for AMY2B Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs554640 -- 103,577,853(-) GATAT(G/T)TACTT intron-variant
rs556215 -- 103,577,731(-) GGAAA(A/T)TAACC reference, missense
rs516220 -- 103,577,659(+) TTGCA(C/T)TTTAT intron-variant
rs518097 -- 103,577,882(+) GTACC(A/T)GTATG intron-variant
rs1827334 -- 103,577,498(+) GTTAA(C/T)GATTG reference, synonymous-codon

Structural Variations from Database of Genomic Variants (DGV) for AMY2B Gene

Variant ID Type Subtype PubMed ID
dgv14n21 CNV Gain 19592680
nsv830904 CNV Loss 17160897
dgv75e1 CNV Complex 17122850
dgv76e1 CNV Complex 17122850
dgv77e1 CNV Complex 17122850
nsv428157 CNV Gain+Loss 18775914
nsv526367 CNV Gain 19592680
nsv830915 CNV Gain+Loss 17160897
nsv523177 CNV Gain 19592680
dgv294n71 CNV Gain 21882294
dgv295n71 CNV Gain+Loss 21882294
nsv871791 CNV Loss 21882294
dgv78e1 CNV Complex 17122850
dgv3n64 CNV Gain 17921354
nsv511132 CNV Gain 21212237
dgv297n71 CNV Gain 21882294
dgv298n71 CNV Gain 21882294
dgv299n71 CNV Gain 21882294
nsv10428 CNV Gain+Loss 18304495
esv23292 CNV Gain+Loss 19812545
esv33927 CNV Gain 17666407
nsv870628 CNV Gain 21882294
nsv517215 CNV Gain+Loss 19592680
nsv442937 CNV CNV 18776908
dgv300n71 CNV Loss 21882294
nsv514909 CNV Complex 21397061
esv1004547 CNV Gain 20482838
nsv823686 CNV Gain 20364138

Variation tolerance for AMY2B Gene

Residual Variation Intolerance Score: 92.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.79; 58.19% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for AMY2B Gene

Disorders for AMY2B Gene

Relevant External Links for AMY2B

Genetic Association Database (GAD)
AMY2B
Human Genome Epidemiology (HuGE) Navigator
AMY2B
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
AMY2B

No disorders were found for AMY2B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for AMY2B Gene

Publications for AMY2B Gene

  1. Identification of the characteristic amino-acid sequence for human alpha-amylase encoded by the AMY2B gene. (PMID: 8268204) Omichi K. … Hase S. (Biochim. Biophys. Acta 1993) 2 3 4 67
  2. Drugs, their targets and the nature and number of drug targets. (PMID: 17016423) Imming P. … Meyer A. (Nat Rev Drug Discov 2006) 25 26
  3. How many drug targets are there? (PMID: 17139284) Overington J.P. … Hopkins A.L. (Nat Rev Drug Discov 2006) 25 26
  4. alpha-Amylase expressed in human liver is encoded by the AMY-2B gene identified in tumorous tissues. (PMID: 11408008) Koyama I. … Komoda T. (Clin. Chim. Acta 2001) 3 23
  5. The Protein Data Bank. (PMID: 10592235) Berman H.M. … Bourne P.E. (Nucleic Acids Res. 2000) 25 26

Products for AMY2B Gene

Sources for AMY2B Gene

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