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Aliases for AMY2A Gene

Aliases for AMY2A Gene

  • Amylase, Alpha 2A (Pancreatic) 2 3
  • 1,4-Alpha-D-Glucan Glucanohydrolase 3 4
  • EC 3.2.1.1 4 64
  • PA 3 4
  • Amylase, Alpha 2A; Pancreatic 2
  • Pancreatic Amylase Alpha 2A 3
  • Pancreatic Alpha-Amylase 3
  • Glycogenase 3
  • AMY2 3

External Ids for AMY2A Gene

Previous Symbols for AMY2A Gene

  • AMY2

Summaries for AMY2A Gene

Entrez Gene Summary for AMY2A Gene

  • This gene encodes a member of the alpha-amylase family of proteins. Amylases are secreted proteins that hydrolyze 1,4-alpha-glucoside bonds in oligosaccharides and polysaccharides, catalyzing the first step in digestion of dietary starch and glycogen. This gene and several family members are present in a gene cluster on chromosome 1. This gene encodes an amylase isoenzyme produced by the pancreas. [provided by RefSeq, Jan 2015]

GeneCards Summary for AMY2A Gene

AMY2A (Amylase, Alpha 2A (Pancreatic)) is a Protein Coding gene. Diseases associated with AMY2A include exstrophy of the bladder. Among its related pathways are Metabolism and Metabolism. GO annotations related to this gene include calcium ion binding and alpha-amylase activity. An important paralog of this gene is AMY2B.

Gene Wiki entry for AMY2A Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for AMY2A Gene

Genomics for AMY2A Gene

Genomic Location for AMY2A Gene

Start:
103,616,811 bp from pter
End:
103,625,780 bp from pter
Size:
8,970 bases
Orientation:
Plus strand

Genomic View for AMY2A Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for AMY2A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for AMY2A Gene

Regulatory Elements for AMY2A Gene

Proteins for AMY2A Gene

  • Protein details for AMY2A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P04746-AMYP_HUMAN
    Recommended name:
    Pancreatic alpha-amylase
    Protein Accession:
    P04746
    Secondary Accessions:
    • B9EJG1
    • Q9UBH3

    Protein attributes for AMY2A Gene

    Size:
    511 amino acids
    Molecular mass:
    57707 Da
    Cofactor:
    Name=Ca(2+); Xref=ChEBI:CHEBI:29108; Note=Binds 1 Ca(2+) ion per subunit.;
    Cofactor:
    Name=chloride; Xref=ChEBI:CHEBI:17996; Note=Binds 1 Cl(-) ion per subunit.;
    Quaternary structure:
    • Monomer

    Three dimensional structures from OCA and Proteopedia for AMY2A Gene

    Alternative splice isoforms for AMY2A Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for AMY2A Gene

Proteomics data for AMY2A Gene at MOPED

Post-translational modifications for AMY2A Gene

  • Modification sites at PhosphoSitePlus
  • Glycosylation at Asn476

Other Protein References for AMY2A Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Domains for AMY2A Gene

UniProtKB/Swiss-Prot:

AMYP_HUMAN
Family:
  • Belongs to the glycosyl hydrolase 13 family.:
    • P04746
genes like me logo Genes that share domains with AMY2A: view

No data available for Gene Families for AMY2A Gene

Function for AMY2A Gene

Molecular function for AMY2A Gene

GENATLAS Biochemistry: amylase,alpha-2A,pancreas,see AMY@
UniProtKB/Swiss-Prot CatalyticActivity: Endohydrolysis of (1->4)-alpha-D-glucosidic linkages in polysaccharides containing three or more (1->4)-alpha-linked D-glucose units

Enzyme Numbers (IUBMB) for AMY2A Gene

Gene Ontology (GO) - Molecular Function for AMY2A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003824 catalytic activity --
GO:0004556 alpha-amylase activity IDA 10769135
GO:0005509 calcium ion binding IDA 10769135
GO:0031404 chloride ion binding IDA 10769135
GO:0043169 cation binding --
genes like me logo Genes that share ontologies with AMY2A: view

No data available for Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for AMY2A Gene

Localization for AMY2A Gene

Subcellular locations from UniProtKB/Swiss-Prot for AMY2A Gene

Secreted, extracellular space.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for AMY2A Gene COMPARTMENTS Subcellular localization image for AMY2A gene
Compartment Confidence
extracellular 5
mitochondrion 1
peroxisome 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for AMY2A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005615 extracellular space IDA 10769135
GO:0070062 extracellular exosome IDA 23376485
genes like me logo Genes that share ontologies with AMY2A: view

Pathways for AMY2A Gene

genes like me logo Genes that share pathways with AMY2A: view

Gene Ontology (GO) - Biological Process for AMY2A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005975 carbohydrate metabolic process TAS --
GO:0016052 carbohydrate catabolic process IDA 10769135
GO:0044245 polysaccharide digestion TAS --
GO:0044281 small molecule metabolic process TAS --
genes like me logo Genes that share ontologies with AMY2A: view

Transcripts for AMY2A Gene

mRNA/cDNA for AMY2A Gene

Unigene Clusters for AMY2A Gene

Amylase, alpha 2A (pancreatic):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for AMY2A Gene

No ASD Table

Relevant External Links for AMY2A Gene

GeneLoc Exon Structure for
AMY2A
ECgene alternative splicing isoforms for
AMY2A

Expression for AMY2A Gene

mRNA expression in normal human tissues for AMY2A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for AMY2A Gene

This gene is overexpressed in Pancreas (52.7).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for AMY2A Gene

SOURCE GeneReport for Unigene cluster for AMY2A Gene Hs.654437

genes like me logo Genes that share expressions with AMY2A: view

Orthologs for AMY2A Gene

This gene was present in the common ancestor of animals.

Orthologs for AMY2A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia AMY2A 36
  • 99.35 (n)
  • 98.82 (a)
cow
(Bos Taurus)
Mammalia -- 37
  • 86 (a)
ManyToMany
AMY2A 36
  • 88 (n)
  • 87.87 (a)
AMY2B 37
  • 86 (a)
ManyToMany
dog
(Canis familiaris)
Mammalia -- 37
  • 88 (a)
ManyToMany
-- 37
  • 90 (a)
ManyToMany
-- 37
  • 89 (a)
ManyToMany
-- 37
  • 90 (a)
ManyToMany
-- 37
  • 90 (a)
ManyToMany
-- 37
  • 90 (a)
ManyToMany
LOC480825 36
  • 89.56 (n)
  • 90.41 (a)
mouse
(Mus musculus)
Mammalia Amy1 36
  • 83.37 (n)
  • 84.93 (a)
Amy1 37
  • 85 (a)
ManyToMany
Amy2a1 37
  • 83 (a)
ManyToMany
Amy2a2 37
  • 86 (a)
ManyToMany
Amy2a3 37
  • 86 (a)
ManyToMany
Amy2a4 37
  • 86 (a)
ManyToMany
Amy2a5 16
Amy2a5 37
  • 86 (a)
ManyToMany
oppossum
(Monodelphis domestica)
Mammalia -- 37
  • 85 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 37
  • 84 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Amy1a 36
  • 82.84 (n)
  • 84.93 (a)
chicken
(Gallus gallus)
Aves AMY1A 37
  • 80 (a)
ManyToMany
AMY2A 36
  • 75.8 (n)
  • 82.97 (a)
AMY2A 37
  • 83 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia -- 37
  • 80 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia amy2b 36
  • 71.23 (n)
  • 74.56 (a)
zebrafish
(Danio rerio)
Actinopterygii amy2a 37
  • 74 (a)
ManyToMany
wufb64c06 36
zgc:66313 37
  • 68 (a)
ManyToMany
zgc:92137 36
  • 67.38 (n)
  • 69.08 (a)
zgc:92137 37
  • 69 (a)
ManyToMany
fruit fly
(Drosophila melanogaster)
Insecta Amy-d 37
  • 54 (a)
ManyToMany
Amy-p 37
  • 54 (a)
ManyToMany
Amyrel 37
  • 49 (a)
ManyToMany
Amyrel 38
  • 48 (a)
Amy-p 38
  • 51 (a)
Amy-d 38
  • 51 (a)
worm
(Caenorhabditis elegans)
Secernentea C50B6.7 37
  • 33 (a)
OneToMany
C50B6.7 38
  • 44 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 54 (a)
OneToMany
Species with no ortholog for AMY2A:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for AMY2A Gene

ENSEMBL:
Gene Tree for AMY2A (if available)
TreeFam:
Gene Tree for AMY2A (if available)

Paralogs for AMY2A Gene

Paralogs for AMY2A Gene

Selected SIMAP similar genes for AMY2A Gene using alignment to 3 proteins:

Pseudogenes.org Pseudogenes for AMY2A Gene

genes like me logo Genes that share paralogs with AMY2A: view

Variants for AMY2A Gene

Sequence variations from dbSNP and Humsavar for AMY2A Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs170146 -- 103,623,508(-) CCTCC(C/T)AAGTA intron-variant
rs188694 -- 103,623,496(-) CTAAG(A/G)CTGTT intron-variant
rs309656 -- 103,622,708(-) AGAAT(A/C)AATTG intron-variant
rs309658 -- 103,623,474(-) ccgca(A/C)ccagc intron-variant
rs309661 -- 103,623,521(-) CCTCC(C/T)ATCTC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for AMY2A Gene

Variant ID Type Subtype PubMed ID
dgv75e1 CNV Complex 17122850
dgv76e1 CNV Complex 17122850
dgv77e1 CNV Complex 17122850
nsv428157 CNV Gain+Loss 18775914
nsv526367 CNV Gain 19592680
nsv830915 CNV Gain+Loss 17160897
dgv294n71 CNV Gain 21882294
dgv295n71 CNV Gain+Loss 21882294
nsv871791 CNV Loss 21882294
dgv78e1 CNV Complex 17122850
dgv297n71 CNV Gain 21882294
dgv298n71 CNV Gain 21882294
dgv299n71 CNV Gain 21882294
nsv10428 CNV Gain+Loss 18304495
esv23292 CNV Gain+Loss 19812545
esv33927 CNV Gain 17666407
nsv870628 CNV Gain 21882294
nsv517215 CNV Gain+Loss 19592680
dgv300n71 CNV Loss 21882294
nsv514909 CNV Complex 21397061
dgv301n71 CNV Gain+Loss 21882294
nsv2176 CNV Loss 18451855
nsv871972 CNV Loss 21882294
nsv871973 CNV Loss 21882294
nsv871974 CNV Gain+Loss 21882294
dgv302n71 CNV Loss 21882294
dgv3n14 CNV Loss 18776910
nsv871984 CNV Loss 21882294
nsv871985 CNV Gain+Loss 21882294
dgv303n71 CNV Gain 21882294
esv1003868 CNV Gain 20482838
esv2715585 CNV Deletion 23290073
nsv871991 CNV Loss 21882294
nsv871992 CNV Gain 21882294
nsv483008 CNV Complex 15286789
dgv304n71 CNV Loss 21882294
dgv305n71 CNV Loss 21882294
dgv1n31 CNV Duplication 19718026
nsv871997 CNV Gain 21882294
dgv306n71 CNV Gain 21882294
dgv307n71 CNV Gain+Loss 21882294
dgv308n71 CNV Gain+Loss 21882294
nsv471345 CNV Duplication 19718026
nsv482048 CNV Gain 20164927
dgv58n67 CNV Gain 20364138
nsv872018 CNV Loss 21882294
dgv309n71 CNV Loss 21882294

Relevant External Links for AMY2A Gene

HapMap Linkage Disequilibrium report
AMY2A

Disorders for AMY2A Gene

(1) MalaCards Diseases for AMY2A Gene

Search for AMY2A Gene in MalaCards »

(2) Novoseek inferred disease relationships for AMY2A Gene

Disease -log(P) Hits PubMed IDs
pancreatitis 44.4 2
cancer lung 13.8 1

Relevant External Links for AMY2A

Genetic Association Database (GAD)
AMY2A
Human Genome Epidemiology (HuGE) Navigator
AMY2A
genes like me logo Genes that share disorders with AMY2A: view

No data available for UniProtKB/Swiss-Prot for AMY2A Gene

Publications for AMY2A Gene

  1. Population genetic studies of the pancreatic amylase (AMY2, E.C. 3.2.1.1) in Bulgaria. (PMID: 15571103) Baltova S. … Scheil H.G. (Coll Antropol 2004) 3 23 49
  2. Human pancreatic amylase is encoded by two different genes. (PMID: 3260028) Groot P.C. … Frants R.R. (Nucleic Acids Res. 1988) 2 3 4
  3. A complementary DNA sequence that predicts a human pancreatic amylase primary structure consistent with the electrophoretic mobility of the common isozyme, Amy2 A. (PMID: 6336237) Wise R.J. … Rutter W.J. (Mol. Biol. Med. 1984) 3 4
  4. Corrected sequences of cDNAs for human salivary and pancreatic alpha- amylases. (PMID: 6610603) Nakamura Y. … Matsubara K. (Gene 1984) 3 4
  5. The active center of a mammalian alpha-amylase. Structure of the complex of a pancreatic alpha-amylase with a carbohydrate inhibitor refined to 2.2-A resolution. (PMID: 8193143) Qian M. … Payan F. (Biochemistry 1994) 3 4

Products for AMY2A Gene

  • QIAGEN qRT-PCR Assays for microRNAs that regulate AMY2A
    • QuantiTect SYBR Green Assays in human,mouse,rat
    • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
    • QuantiFast Probe-based Assays in human,mouse,rat
    • Predesigned siRNA for gene silencing in human,mouse,rat for AMY2A
    • Block miRNA regulation of AMY2A using miScript Target Protectors

    Sources for AMY2A Gene

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