Free for academic non-profit institutions. Other users need a Commercial license

Aliases for AMY2A Gene

Aliases for AMY2A Gene

  • Amylase, Alpha 2A (Pancreatic) 2 3 5
  • 1,4-Alpha-D-Glucan Glucanohydrolase 3 4
  • EC 3.2.1.1 4 63
  • PA 3 4
  • Amylase, Alpha 2A; Pancreatic 2
  • Pancreatic Amylase Alpha 2A 3
  • Glycogenase 3
  • AMY2 3

External Ids for AMY2A Gene

Previous HGNC Symbols for AMY2A Gene

  • AMY2

Previous GeneCards Identifiers for AMY2A Gene

  • GC01P104824
  • GC01P103168
  • GC01P103423
  • GC01P103871
  • GC01P103961
  • GC01P104115
  • GC01P102215
  • GC01P104159

Summaries for AMY2A Gene

Entrez Gene Summary for AMY2A Gene

  • This gene encodes a member of the alpha-amylase family of proteins. Amylases are secreted proteins that hydrolyze 1,4-alpha-glucoside bonds in oligosaccharides and polysaccharides, catalyzing the first step in digestion of dietary starch and glycogen. This gene and several family members are present in a gene cluster on chromosome 1. This gene encodes an amylase isoenzyme produced by the pancreas. [provided by RefSeq, Jan 2015]

GeneCards Summary for AMY2A Gene

AMY2A (Amylase, Alpha 2A (Pancreatic)) is a Protein Coding gene. Diseases associated with AMY2A include Exstrophy Of The Bladder. Among its related pathways are Glycosaminoglycan metabolism and Pancreatic secretion. GO annotations related to this gene include calcium ion binding and alpha-amylase activity. An important paralog of this gene is AMY2B.

Gene Wiki entry for AMY2A Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for AMY2A Gene

Genomics for AMY2A Gene

Regulatory Elements for AMY2A Gene

Enhancers for AMY2A Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around AMY2A on UCSC Golden Path with GeneCards custom track

Genomic Location for AMY2A Gene

Chromosome:
1
Start:
103,616,811 bp from pter
End:
103,625,780 bp from pter
Size:
8,970 bases
Orientation:
Plus strand

Genomic View for AMY2A Gene

Genes around AMY2A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
AMY2A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for AMY2A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for AMY2A Gene

Proteins for AMY2A Gene

  • Protein details for AMY2A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P04746-AMYP_HUMAN
    Recommended name:
    Pancreatic alpha-amylase
    Protein Accession:
    P04746
    Secondary Accessions:
    • B9EJG1
    • Q9UBH3

    Protein attributes for AMY2A Gene

    Size:
    511 amino acids
    Molecular mass:
    57707 Da
    Cofactor:
    Name=Ca(2+); Xref=ChEBI:CHEBI:29108;
    Cofactor:
    Name=chloride; Xref=ChEBI:CHEBI:17996;
    Quaternary structure:
    • Monomer.

    Three dimensional structures from OCA and Proteopedia for AMY2A Gene

    Alternative splice isoforms for AMY2A Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for AMY2A Gene

Proteomics data for AMY2A Gene at MOPED

Post-translational modifications for AMY2A Gene

  • Glycosylation at Asn 476
  • Modification sites at PhosphoSitePlus

Other Protein References for AMY2A Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains & Families for AMY2A Gene

Suggested Antigen Peptide Sequences for AMY2A Gene

Graphical View of Domain Structure for InterPro Entry

P04746

UniProtKB/Swiss-Prot:

AMYP_HUMAN :
  • Belongs to the glycosyl hydrolase 13 family.
Family:
  • Belongs to the glycosyl hydrolase 13 family.
genes like me logo Genes that share domains with AMY2A: view

No data available for Gene Families for AMY2A Gene

Function for AMY2A Gene

Molecular function for AMY2A Gene

GENATLAS Biochemistry:
amylase,alpha-2A,pancreas,see AMY@
UniProtKB/Swiss-Prot CatalyticActivity:
Endohydrolysis of (1->4)-alpha-D-glucosidic linkages in polysaccharides containing three or more (1->4)-alpha-linked D-glucose units.

Enzyme Numbers (IUBMB) for AMY2A Gene

Gene Ontology (GO) - Molecular Function for AMY2A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0031404 chloride ion binding IDA 10769135
genes like me logo Genes that share ontologies with AMY2A: view
genes like me logo Genes that share phenotypes with AMY2A: view

Animal Model Products

No data available for Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for AMY2A Gene

Localization for AMY2A Gene

Subcellular locations from UniProtKB/Swiss-Prot for AMY2A Gene

Secreted, extracellular space.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for AMY2A Gene COMPARTMENTS Subcellular localization image for AMY2A gene
Compartment Confidence
extracellular 5
cytosol 1
golgi apparatus 1
mitochondrion 1
peroxisome 1
plasma membrane 1
vacuole 1

No data available for Gene Ontology (GO) - Cellular Components for AMY2A Gene

Pathways & Interactions for AMY2A Gene

genes like me logo Genes that share pathways with AMY2A: view

Gene Ontology (GO) - Biological Process for AMY2A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016052 carbohydrate catabolic process IDA 10769135
GO:0044281 small molecule metabolic process TAS --
genes like me logo Genes that share ontologies with AMY2A: view

No data available for SIGNOR curated interactions for AMY2A Gene

Drugs & Compounds for AMY2A Gene

(16) Drugs for AMY2A Gene - From: DrugBank, DGIdb, and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Acarbose Approved, Investigational Pharma inhibitor, Target Alpha-glucosidase inhibitor, Glucosidase alpha inhibitor (intestinal) 81
Miglitol Approved Pharma Enzyme 12
Icodextrin Approved, Investigational Pharma Enzyme, substrate 30
Pyroglutamic acid Experimental Pharma Target, Enzyme 0
4,6-Dideoxy-4-{[4,5,6-Trihydroxy-3-(Hydroxymethyl)Cyclohex-2-En-1-Yl]Amino}-Alpha-D-Lyxo-Hexopyranosyl-(1->4)-Alpha-D-Threo-Hexopyranosyl-(1->6)-Alpha-L-Threo-Hexopyranose Experimental Pharma Target, Enzyme 0

(3) Additional Compounds for AMY2A Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Chloride ion
  • Bertholite
  • Chloor
  • Chlor
  • Chlore
  • Chloride
16887-00-6
Dextrin
  • British gum
  • Caloreen
  • Corn dextrin
  • Crystal gum
  • Dextrid
9004-53-9
Water
  • Dihydrogen oxide
  • Steam
7732-18-5
genes like me logo Genes that share compounds with AMY2A: view

Transcripts for AMY2A Gene

Unigene Clusters for AMY2A Gene

Amylase, alpha 2A (pancreatic):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for AMY2A Gene

No ASD Table

Relevant External Links for AMY2A Gene

GeneLoc Exon Structure for
AMY2A
ECgene alternative splicing isoforms for
AMY2A

Expression for AMY2A Gene

mRNA expression in normal human tissues for AMY2A Gene

mRNA differential expression in normal tissues according to GTEx for AMY2A Gene

This gene is overexpressed in Pancreas (x52.7).

Protein differential expression in normal tissues from HIPED for AMY2A Gene

This gene is overexpressed in Pancreatic juice (59.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for AMY2A Gene



SOURCE GeneReport for Unigene cluster for AMY2A Gene Hs.654437

mRNA Expression by UniProt/SwissProt for AMY2A Gene

P04746-AMYP_HUMAN
Tissue specificity: Detected in pancreas (at protein level).
genes like me logo Genes that share expression patterns with AMY2A: view

Protein tissue co-expression partners for AMY2A Gene

- Elite partner

Primer Products

Orthologs for AMY2A Gene

This gene was present in the common ancestor of animals.

Orthologs for AMY2A Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia AMY2A 35
  • 88 (n)
  • 87.87 (a)
-- 36
  • 86 (a)
ManyToMany
AMY2B 36
  • 86 (a)
ManyToMany
dog
(Canis familiaris)
Mammalia LOC480825 35
  • 89.56 (n)
  • 90.41 (a)
-- 36
  • 88 (a)
ManyToMany
-- 36
  • 90 (a)
ManyToMany
-- 36
  • 89 (a)
ManyToMany
-- 36
  • 90 (a)
ManyToMany
-- 36
  • 90 (a)
ManyToMany
-- 36
  • 90 (a)
ManyToMany
mouse
(Mus musculus)
Mammalia Amy1 35
  • 83.37 (n)
  • 84.93 (a)
Amy1 16
Amy1 36
  • 85 (a)
ManyToMany
Amy2a1 36
  • 83 (a)
ManyToMany
Amy2a2 36
  • 86 (a)
ManyToMany
Amy2a3 36
  • 86 (a)
ManyToMany
Amy2a4 36
  • 86 (a)
ManyToMany
Amy2a5 36
  • 86 (a)
ManyToMany
chimpanzee
(Pan troglodytes)
Mammalia AMY2A 35
  • 99.35 (n)
  • 98.82 (a)
rat
(Rattus norvegicus)
Mammalia Amy1a 35
  • 82.84 (n)
  • 84.93 (a)
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 85 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 84 (a)
OneToMany
chicken
(Gallus gallus)
Aves AMY2A 35
  • 75.8 (n)
  • 82.97 (a)
AMY1A 36
  • 80 (a)
ManyToMany
AMY2A 36
  • 83 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 80 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia amy2b 35
  • 71.23 (n)
  • 74.56 (a)
zebrafish
(Danio rerio)
Actinopterygii wufb64c06 35
zgc:92137 35
  • 67.38 (n)
  • 69.08 (a)
amy2a 36
  • 74 (a)
ManyToMany
zgc:66313 36
  • 68 (a)
ManyToMany
zgc:92137 36
  • 69 (a)
ManyToMany
fruit fly
(Drosophila melanogaster)
Insecta Amy-d 37
  • 51 (a)
Amy-p 37
  • 51 (a)
Amyrel 37
  • 48 (a)
Amy-d 36
  • 54 (a)
ManyToMany
Amy-p 36
  • 54 (a)
ManyToMany
Amyrel 36
  • 49 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea C50B6.7 37
  • 44 (a)
C50B6.7 36
  • 33 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 54 (a)
OneToMany
Species with no ortholog for AMY2A:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for AMY2A Gene

ENSEMBL:
Gene Tree for AMY2A (if available)
TreeFam:
Gene Tree for AMY2A (if available)

Paralogs for AMY2A Gene

Paralogs for AMY2A Gene

(4) SIMAP similar genes for AMY2A Gene using alignment to 3 proteins:

Pseudogenes.org Pseudogenes for AMY2A Gene

genes like me logo Genes that share paralogs with AMY2A: view

Variants for AMY2A Gene

Sequence variations from dbSNP and Humsavar for AMY2A Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs170146 -- 103,623,508(-) CCTCC(C/T)AAGTA intron-variant
rs188694 -- 103,623,496(-) CTAAG(A/G)CTGTT intron-variant
rs309656 -- 103,622,708(-) AGAAT(A/C)AATTG intron-variant
rs309658 -- 103,623,474(-) ccgca(A/C)ccagc intron-variant
rs309661 -- 103,623,521(-) CCTCC(C/T)ATCTC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for AMY2A Gene

Variant ID Type Subtype PubMed ID
dgv75e1 CNV Complex 17122850
dgv76e1 CNV Complex 17122850
dgv77e1 CNV Complex 17122850
nsv428157 CNV Gain+Loss 18775914
nsv526367 CNV Gain 19592680
nsv830915 CNV Gain+Loss 17160897
dgv294n71 CNV Gain 21882294
dgv295n71 CNV Gain+Loss 21882294
nsv871791 CNV Loss 21882294
dgv78e1 CNV Complex 17122850
dgv297n71 CNV Gain 21882294
dgv298n71 CNV Gain 21882294
dgv299n71 CNV Gain 21882294
nsv10428 CNV Gain+Loss 18304495
esv23292 CNV Gain+Loss 19812545
esv33927 CNV Gain 17666407
nsv870628 CNV Gain 21882294
nsv517215 CNV Gain+Loss 19592680
dgv300n71 CNV Loss 21882294
nsv514909 CNV Complex 21397061
dgv301n71 CNV Gain+Loss 21882294
nsv2176 CNV Loss 18451855
nsv871972 CNV Loss 21882294
nsv871973 CNV Loss 21882294
nsv871974 CNV Gain+Loss 21882294
dgv302n71 CNV Loss 21882294
dgv3n14 CNV Loss 18776910
nsv871984 CNV Loss 21882294
nsv871985 CNV Gain+Loss 21882294
dgv303n71 CNV Gain 21882294
esv1003868 CNV Gain 20482838
esv2715585 CNV Deletion 23290073
nsv871991 CNV Loss 21882294
nsv871992 CNV Gain 21882294
nsv483008 CNV Complex 15286789
dgv304n71 CNV Loss 21882294
dgv305n71 CNV Loss 21882294
dgv1n31 CNV Duplication 19718026
nsv871997 CNV Gain 21882294
dgv306n71 CNV Gain 21882294
dgv307n71 CNV Gain+Loss 21882294
dgv308n71 CNV Gain+Loss 21882294
nsv471345 CNV Duplication 19718026
nsv482048 CNV Gain 20164927
dgv58n67 CNV Gain 20364138
nsv872018 CNV Loss 21882294
dgv309n71 CNV Loss 21882294

Variation tolerance for AMY2A Gene

Gene Damage Index Score: 6.63; 78.28% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for AMY2A Gene

Disorders for AMY2A Gene

MalaCards: The human disease database

(1) MalaCards diseases for AMY2A Gene - From: GeneCards

Disorder Aliases PubMed IDs
exstrophy of the bladder
  • bladder exstrophy
- elite association - COSMIC cancer census association via MalaCards
Search AMY2A in MalaCards View complete list of genes associated with diseases

Relevant External Links for AMY2A

Genetic Association Database (GAD)
AMY2A
Human Genome Epidemiology (HuGE) Navigator
AMY2A
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
AMY2A
genes like me logo Genes that share disorders with AMY2A: view

No data available for UniProtKB/Swiss-Prot and Genatlas for AMY2A Gene

Publications for AMY2A Gene

  1. Human pancreatic amylase is encoded by two different genes. (PMID: 3260028) Groot P.C. … Frants R.R. (Nucleic Acids Res. 1988) 2 3 4 67
  2. Amylase alpha-2A autoantibodies: novel marker of autoimmune pancreatitis and fulminant type 1 diabetes. (PMID: 19001184) Endo T. … Kobayashi T. (Diabetes 2009) 3 23
  3. Genome-wide analysis for micro-aberrations in familial exstrophy of the bladder using array-based comparative genomic hybridization. (PMID: 17669146) Reutter H. … Weber R.G. (BJU Int. 2007) 3 23
  4. Population genetic studies of the pancreatic amylase (AMY2, E.C. 3.2.1.1) in Bulgaria. (PMID: 15571103) Baltova S. … Scheil H.G. (Coll Antropol 2004) 3 23
  5. Inhibitory effects of human and porcine alpha-amylase on CCK-8-stimulated lipase secretion of isolated rat pancreatic acini. (PMID: 12890998) Jonas L. … Toomik P. (Pancreatology 2003) 25 26

Products for AMY2A Gene

Sources for AMY2A Gene

Content