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Aliases for AMY2A Gene

Aliases for AMY2A Gene

  • Amylase, Alpha 2A (Pancreatic) 2 3
  • 1,4-Alpha-D-Glucan Glucanohydrolase 3 4
  • EC 4 63
  • PA 3 4
  • Amylase, Alpha 2A; Pancreatic 2
  • Pancreatic Amylase Alpha 2A 3
  • Pancreatic Alpha-Amylase 3
  • Glycogenase 3
  • AMY2 3

External Ids for AMY2A Gene

Previous HGNC Symbols for AMY2A Gene

  • AMY2

Previous GeneCards Identifiers for AMY2A Gene

  • GC01P104824
  • GC01P103168
  • GC01P103423
  • GC01P103871
  • GC01P103961
  • GC01P104115
  • GC01P102215
  • GC01P104159

Summaries for AMY2A Gene

Entrez Gene Summary for AMY2A Gene

  • This gene encodes a member of the alpha-amylase family of proteins. Amylases are secreted proteins that hydrolyze 1,4-alpha-glucoside bonds in oligosaccharides and polysaccharides, catalyzing the first step in digestion of dietary starch and glycogen. This gene and several family members are present in a gene cluster on chromosome 1. This gene encodes an amylase isoenzyme produced by the pancreas. [provided by RefSeq, Jan 2015]

GeneCards Summary for AMY2A Gene

AMY2A (Amylase, Alpha 2A (Pancreatic)) is a Protein Coding gene. Diseases associated with AMY2A include exstrophy of the bladder. Among its related pathways are Metabolism and Metabolism. GO annotations related to this gene include calcium ion binding and alpha-amylase activity. An important paralog of this gene is AMY2B.

Gene Wiki entry for AMY2A Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for AMY2A Gene

Genomics for AMY2A Gene

Regulatory Elements for AMY2A Gene

Genomic Location for AMY2A Gene

103,616,811 bp from pter
103,625,780 bp from pter
8,970 bases
Plus strand

Genomic View for AMY2A Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for AMY2A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for AMY2A Gene

Proteins for AMY2A Gene

  • Protein details for AMY2A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Pancreatic alpha-amylase
    Protein Accession:
    Secondary Accessions:
    • B9EJG1
    • Q9UBH3

    Protein attributes for AMY2A Gene

    511 amino acids
    Molecular mass:
    57707 Da
    Name=Ca(2+); Xref=ChEBI:CHEBI:29108; Note=Binds 1 Ca(2+) ion per subunit.;
    Name=chloride; Xref=ChEBI:CHEBI:17996; Note=Binds 1 Cl(-) ion per subunit.;
    Quaternary structure:
    • Monomer

    Three dimensional structures from OCA and Proteopedia for AMY2A Gene

    Alternative splice isoforms for AMY2A Gene


neXtProt entry for AMY2A Gene

Proteomics data for AMY2A Gene at MOPED

Post-translational modifications for AMY2A Gene

  • Glycosylation at Asn476
  • Modification sites at PhosphoSitePlus

Other Protein References for AMY2A Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Domains for AMY2A Gene

Suggested Antigen Peptide Sequences for AMY2A Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the glycosyl hydrolase 13 family.
  • Belongs to the glycosyl hydrolase 13 family.
genes like me logo Genes that share domains with AMY2A: view

No data available for Gene Families for AMY2A Gene

Function for AMY2A Gene

Molecular function for AMY2A Gene

GENATLAS Biochemistry:
amylase,alpha-2A,pancreas,see AMY@
UniProtKB/Swiss-Prot CatalyticActivity:
Endohydrolysis of (1->4)-alpha-D-glucosidic linkages in polysaccharides containing three or more (1->4)-alpha-linked D-glucose units

Enzyme Numbers (IUBMB) for AMY2A Gene

Gene Ontology (GO) - Molecular Function for AMY2A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003824 catalytic activity --
GO:0004556 alpha-amylase activity IDA 10769135
GO:0005509 calcium ion binding IDA 10769135
GO:0031404 chloride ion binding IDA 10769135
GO:0043169 cation binding --
genes like me logo Genes that share ontologies with AMY2A: view

Animal Model Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for AMY2A

In Situ Assay Products

Flow Cytometry Products

No data available for Phenotypes , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for AMY2A Gene

Localization for AMY2A Gene

Subcellular locations from UniProtKB/Swiss-Prot for AMY2A Gene

Secreted, extracellular space.

Subcellular locations from

Jensen Localization Image for AMY2A Gene COMPARTMENTS Subcellular localization image for AMY2A gene
Compartment Confidence
extracellular 5
mitochondrion 1
peroxisome 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for AMY2A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005615 extracellular space IDA 10769135
GO:0070062 extracellular exosome IDA 23376485
genes like me logo Genes that share ontologies with AMY2A: view

Pathways for AMY2A Gene

genes like me logo Genes that share pathways with AMY2A: view

Gene Ontology (GO) - Biological Process for AMY2A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005975 carbohydrate metabolic process TAS --
GO:0016052 carbohydrate catabolic process IDA 10769135
GO:0044245 polysaccharide digestion TAS --
GO:0044281 small molecule metabolic process TAS --
genes like me logo Genes that share ontologies with AMY2A: view

Drugs for AMY2A Gene

(15) Drugbank Compounds for AMY2A Gene

Compound Status Synonyms Cas Number PubChem ID Type Actions PubMed IDs
  • Acarbosa
56180-94-0 441184 Target inhibitor approved, investigational
  • Icodextrin
337376-15-5 Enzyme substrate approved, investigational
  • Glyset
72432-03-2 441314 Enzyme approved
46936699 Target, Enzyme experimental
4369393 Target experimental

(7) HMDB Compounds for AMY2A Gene

Compound Synonyms Cas Number PubMed IDs
  • Ca
Chloride ion
  • Bertholite
  • British gum
genes like me logo Genes that share compounds with AMY2A: view

Transcripts for AMY2A Gene

mRNA/cDNA for AMY2A Gene

Unigene Clusters for AMY2A Gene

Amylase, alpha 2A (pancreatic):
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for AMY2A

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for AMY2A Gene

No ASD Table

Relevant External Links for AMY2A Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for AMY2A Gene

mRNA expression in normal human tissues for AMY2A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for AMY2A Gene

This gene is overexpressed in Pancreas (52.7).

Protein differential expression in normal tissues for AMY2A Gene

This gene is overexpressed in Pancreatic juice (59.8).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for AMY2A Gene

SOURCE GeneReport for Unigene cluster for AMY2A Gene Hs.654437

genes like me logo Genes that share expressions with AMY2A: view

Expression partners for AMY2A Gene

* - Elite partner

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for AMY2A Gene

Orthologs for AMY2A Gene

This gene was present in the common ancestor of animals.

Orthologs for AMY2A Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia AMY2A 35
  • 88 (n)
  • 87.87 (a)
-- 36
  • 86 (a)
AMY2B 36
  • 86 (a)
(Canis familiaris)
Mammalia LOC480825 35
  • 89.56 (n)
  • 90.41 (a)
-- 36
  • 88 (a)
-- 36
  • 90 (a)
-- 36
  • 89 (a)
-- 36
  • 90 (a)
-- 36
  • 90 (a)
-- 36
  • 90 (a)
(Mus musculus)
Mammalia Amy1 35
  • 83.37 (n)
  • 84.93 (a)
Amy2a5 16
Amy1 36
  • 85 (a)
Amy2a1 36
  • 83 (a)
Amy2a2 36
  • 86 (a)
Amy2a3 36
  • 86 (a)
Amy2a4 36
  • 86 (a)
Amy2a5 36
  • 86 (a)
(Pan troglodytes)
Mammalia AMY2A 35
  • 99.35 (n)
  • 98.82 (a)
(Rattus norvegicus)
Mammalia Amy1a 35
  • 82.84 (n)
  • 84.93 (a)
(Monodelphis domestica)
Mammalia -- 36
  • 85 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 84 (a)
(Gallus gallus)
Aves AMY2A 35
  • 75.8 (n)
  • 82.97 (a)
AMY1A 36
  • 80 (a)
AMY2A 36
  • 83 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 80 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia amy2b 35
  • 71.23 (n)
  • 74.56 (a)
(Danio rerio)
Actinopterygii wufb64c06 35
zgc:92137 35
  • 67.38 (n)
  • 69.08 (a)
amy2a 36
  • 74 (a)
zgc:66313 36
  • 68 (a)
zgc:92137 36
  • 69 (a)
fruit fly
(Drosophila melanogaster)
Insecta Amy-d 37
  • 51 (a)
Amy-p 37
  • 51 (a)
Amyrel 37
  • 48 (a)
Amy-d 36
  • 54 (a)
Amy-p 36
  • 54 (a)
Amyrel 36
  • 49 (a)
(Caenorhabditis elegans)
Secernentea C50B6.7 37
  • 44 (a)
C50B6.7 36
  • 33 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 54 (a)
Species with no ortholog for AMY2A:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for AMY2A Gene

Gene Tree for AMY2A (if available)
Gene Tree for AMY2A (if available)

Paralogs for AMY2A Gene

Paralogs for AMY2A Gene

(4) SIMAP similar genes for AMY2A Gene using alignment to 3 proteins: Pseudogenes for AMY2A Gene

genes like me logo Genes that share paralogs with AMY2A: view

Variants for AMY2A Gene

Sequence variations from dbSNP and Humsavar for AMY2A Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs554496554 -- 103,617,088(+) TTATG(G/T)AAAGT upstream-variant-2KB
rs554311292 -- 103,618,476(+) ATGGT(C/G)AATAG intron-variant
rs554150874 -- 103,618,783(+) CTTGT(A/G)GGAAA intron-variant
rs554069758 -- 103,617,933(+) ACTTA(C/T)GAAGA intron-variant
rs553959668 -- 103,616,133(+) AGCCG(A/C)ACCAA upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for AMY2A Gene

Variant ID Type Subtype PubMed ID
dgv75e1 CNV Complex 17122850
dgv76e1 CNV Complex 17122850
dgv77e1 CNV Complex 17122850
nsv428157 CNV Gain+Loss 18775914
nsv526367 CNV Gain 19592680
nsv830915 CNV Gain+Loss 17160897
dgv294n71 CNV Gain 21882294
dgv295n71 CNV Gain+Loss 21882294
nsv871791 CNV Loss 21882294
dgv78e1 CNV Complex 17122850
dgv297n71 CNV Gain 21882294
dgv298n71 CNV Gain 21882294
dgv299n71 CNV Gain 21882294
nsv10428 CNV Gain+Loss 18304495
esv23292 CNV Gain+Loss 19812545
esv33927 CNV Gain 17666407
nsv870628 CNV Gain 21882294
nsv517215 CNV Gain+Loss 19592680
dgv300n71 CNV Loss 21882294
nsv514909 CNV Complex 21397061
dgv301n71 CNV Gain+Loss 21882294
nsv2176 CNV Loss 18451855
nsv871972 CNV Loss 21882294
nsv871973 CNV Loss 21882294
nsv871974 CNV Gain+Loss 21882294
dgv302n71 CNV Loss 21882294
dgv3n14 CNV Loss 18776910
nsv871984 CNV Loss 21882294
nsv871985 CNV Gain+Loss 21882294
dgv303n71 CNV Gain 21882294
esv1003868 CNV Gain 20482838
esv2715585 CNV Deletion 23290073
nsv871991 CNV Loss 21882294
nsv871992 CNV Gain 21882294
nsv483008 CNV Complex 15286789
dgv304n71 CNV Loss 21882294
dgv305n71 CNV Loss 21882294
dgv1n31 CNV Duplication 19718026
nsv871997 CNV Gain 21882294
dgv306n71 CNV Gain 21882294
dgv307n71 CNV Gain+Loss 21882294
dgv308n71 CNV Gain+Loss 21882294
nsv471345 CNV Duplication 19718026
nsv482048 CNV Gain 20164927
dgv58n67 CNV Gain 20364138
nsv872018 CNV Loss 21882294
dgv309n71 CNV Loss 21882294

Relevant External Links for AMY2A Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for AMY2A Gene

Disorders for AMY2A Gene

MalaCards: The human disease database

MalaCards: The human disease database.

Search for AMY2A Gene in MalaCards »

(1) Disease for AMY2A Gene

(2) Novoseek inferred disease relationships for AMY2A Gene

Disease -log(P) Hits PubMed IDs
pancreatitis 44.4 2
cancer lung 13.8 1

Relevant External Links for AMY2A

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with AMY2A: view

No data available for OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES and Genatlas for AMY2A Gene

Publications for AMY2A Gene

  1. Population genetic studies of the pancreatic amylase (AMY2, E.C. in Bulgaria. (PMID: 15571103) Baltova S. … Scheil H.G. (Coll Antropol 2004) 3 23 48
  2. Human pancreatic amylase is encoded by two different genes. (PMID: 3260028) Groot P.C. … Frants R.R. (Nucleic Acids Res. 1988) 2 3 4
  3. A complementary DNA sequence that predicts a human pancreatic amylase primary structure consistent with the electrophoretic mobility of the common isozyme, Amy2 A. (PMID: 6336237) Wise R.J. … Rutter W.J. (Mol. Biol. Med. 1984) 3 4
  4. Primary structure of human pancreatic alpha-amylase gene: its comparison with human salivary alpha-amylase gene. (PMID: 2450054) Horii A. … Matsubara K. (Gene 1987) 3 4
  5. Concerted evolution of human amylase genes. (PMID: 2452973) Gumucio D.L. … Meisler M.H. (Mol. Cell. Biol. 1988) 3 4

Products for AMY2A Gene

Sources for AMY2A Gene

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