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AMY2A Gene

protein-coding   GIFtS: 57
GCID: GC01P104159

Amylase, Alpha 2A (Pancreatic)

(Previous names: amylase, alpha 2A; pancreatic)
(Previous symbol: AMY2)
  See AMY2A-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Amylase, Alpha 2A (Pancreatic)1 2     alpha-amylase2
AMY21 2     Amylase, Pancreatic, Alpha-2A2
1,4-Alpha-D-Glucan Glucanohydrolase2 3     Found In The Pancreas2
PA2 3     glycogenase2
EC 3.2.1.13 8     Pancreatic Alpha-Amylase2
Amylase, Alpha 2A; Pancreatic1     Pancreatic Amylase 2A2
AMY2B2     Pancreatic Amylase Alpha 2A2

External Ids:    HGNC: 4771   Entrez Gene: 2792   Ensembl: ENSG000002434807   OMIM: 1046505   UniProtKB: P047463   

Export aliases for AMY2A gene to outside databases

Previous GC identifers: GC01P104824 GC01P103168 GC01P103423 GC01P103871 GC01P103961 GC01P104115 GC01P102215


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for AMY2A Gene:
Amylases are secreted proteins that hydrolyze 1,4-alpha-glucoside bonds in oligosaccharides and polysaccharides,
and thus catalyze the first step in digestion of dietary starch and glycogen. The human genome has a cluster of
several amylase genes that are expressed at high levels in either salivary gland or pancreas. This gene encodes
an amylase isoenzyme produced by the pancreas. (provided by RefSeq, Jul 2008)

GeneCards Summary for AMY2A Gene:
AMY2A (amylase, alpha 2A (pancreatic)) is a protein-coding gene. Diseases associated with AMY2A include exstrophy of the bladder. GO annotations related to this gene include alpha-amylase activity and calcium ion binding. An important paralog of this gene is AMY1A.

Gene Wiki entry for AMY2A Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000001.10  NC_018912.2  NT_032977.10  
Regulatory elements:
   Regulatory transcription factor binding sites in the AMY2A gene promoter:
         Sox5   C/EBPbeta   RP58   Nkx2-2   HTF   NF-kappaB   POU2F1   NF-kappaB2   Sox9   NF-kappaB1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidAMY2A promoter sequence
   Search Chromatin IP Primers for AMY2A

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat AMY2A


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p21   Ensembl cytogenetic band:  1p21.1   HGNC cytogenetic band: 1p21.1

AMY2A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
AMY2A gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P104159:  view genomic region     (about GC identifiers)

Start:
104,159,999 bp from pter      End:
104,168,402 bp from pter
Size:
8,404 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: AMYP_HUMAN, P04746 (See protein sequence)
Recommended Name: Pancreatic alpha-amylase precursor  
Size: 511 amino acids; 57707 Da
Cofactor: Binds 1 calcium ion per subunit
Cofactor: Binds 1 chloride ion per subunit
Subunit: Monomer
Selected PDB 3D structures from and Proteopedia for AMY2A (see all 40):
1B2Y (3D)        1BSI (3D)        1CPU (3D)        1HNY (3D)        1KB3 (3D)        1KBB (3D)    
Secondary accessions: Q9UBH3

Explore the universe of human proteins at neXtProt for AMY2A: NX_P04746

Explore proteomics data for AMY2A at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn476
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for AMY2A (P04746) (see all 23)
     YMNHLID  GVRIYVD  YCDVISG  DNHDNQR 


    See AMY2A Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_000690.1  
    ENSEMBL proteins: 
     ENSP00000397582   ENSP00000390832  
    Reactome Protein details: P04746

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    Selected InterPro protein domains (see all 8):
     IPR006046 Alpha_amylase
     IPR006048 A-amylase_b_C
     IPR017853 Glycoside_hydrolase_SF
     IPR006047 Glyco_hydro_13_cat_dom
     IPR013781 Glyco_hydro_catalytic_dom

    Graphical View of Domain Structure for InterPro Entry P04746

    ProtoNet protein and cluster: P04746

    3 Blocks protein domains:
    IPB006046 Alpha-amylase signature
    IPB006048 Alpha amylase
    IPB006589 Alpha amylase


    UniProtKB/Swiss-Prot: AMYP_HUMAN, P04746
    Similarity: Belongs to the glycosyl hydrolase 13 family


    Find genes that share domains with AMY2A           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: AMYP_HUMAN, P04746
    Catalytic activity: Endohydrolysis of (1->4)-alpha-D-glucosidic linkages in polysaccharides containing three or
    more (1->4)-alpha-linked D-glucose units

         Genatlas biochemistry entry for AMY2A:
    amylase,alpha-2A,pancreas,see AMY@

         Enzyme Number (IUBMB): EC 3.2.1.11 2

         Gene Ontology (GO): 5 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003824catalytic activity ----
    GO:0004556alpha-amylase activity IDA10769135
    GO:0005509calcium ion binding IDA10769135
    GO:0031404chloride ion binding IDA10769135
    GO:0043169cation binding ----
         
    Find genes that share ontologies with AMY2A           About GenesLikeMe


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for AMY2A
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    AMYP_HUMAN, P04746: Secreted, extracellular space
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular5
    mitochondrion1
    peroxisome1
    plasma membrane1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region TAS--
    GO:0005615extracellular space IDA10769135

    Find genes that share ontologies with AMY2A           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for AMY2A About   (see all 6)  
    See pathways by source

    SuperPathContained pathways About
    1Metabolism
    Metabolism0.38
    Metabolic pathways0.38
    2MPS VI - Maroteaux-Lamy syndrome
    Metabolism of carbohydrates0.45
    3Glucuronidation
    Starch and sucrose metabolism0.41
    4Pancreatic secretion
    Pancreatic secretion
    5Digestion of dietary carbohydrate
    Digestion of dietary carbohydrate


    Find genes that share SuperPaths with AMY2A           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    1 Reactome Pathway for AMY2A
        Digestion of dietary carbohydrate


    4 Kegg Pathways  (Kegg details for AMY2A):
        Starch and sucrose metabolism
    Metabolic pathways
    Pancreatic secretion
    Carbohydrate digestion and absorption

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for AMY2A
    Interactions:

        Search GeneGlobe Interaction Network for AMY2A

    Selected Interacting proteins for AMY2A (P047463) via UniProtKB, MINT, STRING, and/or I2D (see all 19)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    FAM47E-STBD1O952103I2D: score=1 
    STBD1O952103I2D: score=1 
    GRB2P629933I2D: score=2 
    ACSL1P331213I2D: score=1 
    AKAP8O438233I2D: score=1 
    About this table

    Gene Ontology (GO): 4 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005975carbohydrate metabolic process TAS--
    GO:0016052carbohydrate catabolic process IDA10769135
    GO:0044245polysaccharide digestion TAS--
    GO:0044281small molecule metabolic process TAS--

    Find genes that share ontologies with AMY2A           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
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    Browse Tocris compounds for AMY2A (AMYP)

    7 HMDB Compounds for AMY2A    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--
    ChlorineCl2 (see all 13)16887-00-6--
    DextrinCaloreen (see all 10)9004-53-9--
    MaltodecaoseB-cyclodextrin (see all 19)37331-89-8--
    Maltoheptaosemaltoheptose;alpha-D-Glc-(1->4)-alpha-D-Glc-(1->4)-alpha-D-Glc-(1->4)-alpha-D-Glc-(1->4)-alpha-D-Glc-(1->4)-alpha-D-Glc-(1->4)-D-Glc;Glc(alpha1-4)Glc(alpha1-4)Glc(alpha1-4)Glc(alpha1-4)Glc(alpha1-4)Glc(alpha1-4)Glc 34620-77-4--
    Maltononaosemaltonanoose 6471-60-9--
    WaterDihydrogen oxide (see all 2)7732-18-5--

    Selected DrugBank Compounds for AMY2A (see all 15)    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Icodextrin-- 337376-15-5enzymesubstrate19602601 19602602
    Acarbose-- 56180-94-0targetinhibitor12890998
    4,6-DIDEOXY-4-{[4-[(4-O-HEXOPYRANOSYLHEXOPYRANOSYL)OXY]-5,6-DIHYDROXY-3-(HYDROXYMETHYL)CYCLOHEX-2-EN-1-YL]AMINO}HEXOPYRANOSYL-(1->4)HEXOPYRANOSYL-(1->4)HEXOPYRANOSE-- --target----
    4,6-Dideoxy-4-Amino-Alpha-D-Glucose-- --target----
    enzyme----
    4,6-Dideoxy-4-{[4,5,6-Trihydroxy-3-(Hydroxymethyl)Cyclohex-2-En-1-Yl]Amino}-Alpha-D-Lyxo-Hexopyranosyl-(1->4)-Alpha-D-Threo-Hexopyranosyl-(1->6)-Alpha-L-Threo-Hexopyranose-- --target----
    enzyme----
    4-O-(4,6-Dideoxy-4-{[4,5,6-Trihydroxy-3-(Hydroxymethyl)Cyclohex-2-En-1-Yl]Amino}-Beta-D-Lyxo-Hexopyranosyl)-Alpha-D-Erythro-Hexopyranose-- --target----
    enzyme----
    4-O-(4,6-Dideoxy-4-{[4-[(4-O-Hexopyranosylhexopyranosyl)Oxy]-5,6-Dihydroxy-3-(Hydroxymethyl)Cyclohex-2-En-1-Yl]Amino}Hexopyranosyl)Hexopyranose-- --target----
    enzyme----
    5-Hydroxymethyl-Chonduritol-- --target----
    enzyme----
    6-Deoxy-Alpha-D-Glucose-- --target----
    enzyme----
    Acarbose Derived Hexasaccharide-- --target----
    enzyme----



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for AMY2A gene: 
    NM_000699.2  

    Unigene Cluster for AMY2A:

    Amylase, alpha 2A (pancreatic)
    Hs.654437  [show with all ESTs]
    Unigene Representative Sequence: NM_000699
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000414303(uc010ouq.1 uc001dut.3) ENST00000423678 ENST00000497748

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      QuantiFast Probe-based Assays in human, mouse, rat AMY2A

    Additional mRNA sequence: 

    AK223463.1 BC007060.1 BC146997.1 M28443.1 

    Selected DOTS entries (see all 28):

    DT.449355  DT.75131378  DT.121339842  DT.40220827  DT.121339884  DT.100892344  DT.121339819  DT.121339952 
    DT.92061564  DT.121339828  DT.121339843  DT.92447700  DT.95161677  DT.100753929  DT.100833756  DT.121339827 
    DT.121339913  DT.121339943  DT.92447688  DT.92447694  DT.100736242  DT.100892335  DT.100892336  DT.100892342 

    Selected AceView cDNA sequences (see all 209):

    BC007060 CA941878 BU076711 CB178559 CB069238 BU069133 BU076432 BQ416645 
    BU949946 BQ268738 BI438581 BQ778444 CA952858 BM353682 BU072345 CA849043 
    NM_000699 CK821495 BG654735 BQ416642 BQ287971 BM311500 CA950726 BG654630 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    AMY2A expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    AMY2A Expression
    About this image


    AMY2A expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 5) fully expand
     
     Pancreas (Endocrine System)    fully expand to see all 2 entries
             Beta-like cells
     
     Neurons
             GABAergic Amacrine Cells Inner Nuclear Layer
     
     Neural Ectoderm (Nervous System)
             Neural ectoderm cells
     
     Neural Tube (Nervous System)
             Floor plate-like cells
     
     Eye (Sensory Organs)
             GABAergic Amacrine Cells Inner Nuclear Layer
    AMY2A Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    AMY2A Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.654437
        Custom PCR Arrays for AMY2A
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for AMY2A

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for AMY2A gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Amy2a55
    Amy11
    amylase 2a55
    amylase 1, salivary1
    83.37(n)1
    84.93(a)1
      3 (49.35 cM)5
    117221  NM_007446.21  NP_031472.21 
     1132491765 
    chicken
    (Gallus gallus)
    Aves AMY2A1 amylase, alpha 2A; pancreatic 75.8(n)
    82.97(a)
      414140  NM_001001473.2  NP_001001473.2 
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    80(a)
    1 → many
    4(85537665-85554909)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia amy2b1 amylase, alpha 2B (pancreatic) 71.23(n)
    74.56(a)
      493323  NM_001007947.1  NP_001007948.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufb64c062 Danio rerio cDNA clone MGC66270 IMAGE5410956, complete more 76.51(n)    BC062867.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Amy-p3 alpha-amylase 51(a)
    (best of 3)
      2 53F12   --
    worm
    (Caenorhabditis elegans)
    Secernentea C50B6.73 amylase 44(a)   V(13325025-13327571)   --


    ENSEMBL Gene Tree for AMY2A (if available)
    TreeFam Gene Tree for AMY2A (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for AMY2A gene
    AMY1A2  AMY1C2  AMY2B2  AMY1B2  
    4 SIMAP similar genes for AMY2A using alignment to 3 protein entries:     AMYP_HUMAN (see all proteins):
    AMY2B    AMY1B    AMY1A    AMY1C

    Find genes that share paralogs with AMY2A           About GenesLikeMe


    2 Pseudogenes.org Pseudogenes for AMY2A
    PGOHUM00000244125 PGOHUM00000244824


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for AMY2A (see all 304)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs3096621,2
    C,A--104166324(-) GTCTTC/TATCAT 1 -- int12Minor allele frequency- T:0.00NA 4
    rs1507174161,2
    --104235254(+) CTGGAA/GTGCAT 1 -- us2k10--------
    rs1392410691,2
    C--104235314(+) CATTCC/TCCTGC 1 -- us2k10--------
    rs1424396581,2
    C--104235427(+) GTCTCC/TGTCTC 1 -- us2k10--------
    rs1902122031,2
    --104235449(+) ATCTGC/TCCGCC 1 -- us2k10--------
    rs794082641,2
    C,F--104235790(+) AAGGCG/ACATAC 1 -- us2k11Minor allele frequency- A:0.07NA 120
    rs1817156511,2
    --104235795(+) GCATAA/CCGTAT 1 -- us2k10--------
    rs1839109061,2
    --104235797(+) ATACCA/GTATGA 1 -- us2k10--------
    rs1463735811,2
    --104235840(+) CAATCC/GTTTAA 1 -- us2k10--------
    rs1156261161,2
    F--104235977(+) AAGAAG/CTTGTC 1 -- us2k11Minor allele frequency- C:0.08NA 120

    HapMap Linkage Disequilibrium report for AMY2A (104159999 - 104168402 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for AMY2A (see all 47):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2715585CNV Deletion23290073
    nsv471345CNV Duplication19718026
    dgv1n31CNV Duplication19718026
    nsv871973CNV Loss21882294
    nsv871984CNV Loss21882294
    nsv871791CNV Loss21882294
    dgv304n71CNV Loss21882294
    dgv305n71CNV Loss21882294
    dgv302n71CNV Loss21882294
    dgv3n14CNV Loss18776910

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 104650    OMIM disorders: --

    1 disease for AMY2A:    
    About MalaCards
    exstrophy of the bladder


    Find genes that share disorders with AMY2A           About GenesLikeMe

    2 Novoseek inferred disease relationships for AMY2A gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    pancreatitis 44.4 3 19520060 (1), 19001184 (1)
    cancer lung 13.8 2 7507116 (1)

    Genetic Association Database (GAD): AMY2A
    Human Genome Epidemiology (HuGE) Navigator: AMY2A (3 documents)

    Export disorders for AMY2A gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for AMY2A gene, integrated from 10 sources (see all 52):
    (articles sorted by number of sources associating them with AMY2A)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Human pancreatic amylase is encoded by two different genes. (PubMed id 3260028)1, 2, 3 Groot P.C.... Frants R.R. (Nucleic Acids Res. 1988)
    2. Population genetic studies of the pancreatic amylase (AMY2, E.C. 3.2.1.1) in Bulgaria. (PubMed id 15571103)1, 4, 9 Baltova S. and Scheil H.G. (Coll Antropol 2004)
    3. On the genetic polymorphism of the serum alpha-amylase in the population of the south western Bulgaria (second communication). (PubMed id 16152770)1, 4 Baltova S.D. (Folia Med (Plovdiv) 2005)
    4. Phenotype and allele frequencies of some serum protein polymorphisms in populations of the Balkans. (PubMed id 15648851)1, 4 Scheil H.G....Huckenbeck W. ( Bericht ├╝ber die biologisch-anthropologische Literatur 2004)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    6. Probing the role of the chloride ion in the mechanism of human pancreatic alpha-amylase. (PubMed id 11772019)1, 2 Numao S....Withers S.G. (Biochemistry 2002)
    7. Mechanistic analyses of catalysis in human pancreatic alpha-amylase: detailed kinetic and structural studies of mutants of three conserved carboxylic acids. (PubMed id 11914097)1, 2 Rydberg E.H....Withers S.G. (Biochemistry 2002)
    8. Subsite mapping of the human pancreatic alpha-amylase active site through structural, kinetic, and mutagenesis techniques. (PubMed id 10769135)1, 2 Brayer G.D.... Withers S.G. (Biochemistry 2000)
    9. Cloning, mutagenesis, and structural analysis of human pancreatic alpha-amylase expressed in Pichia pastoris. (PubMed id 10091666)1, 2 Rydberg E.H....Withers S.G. (Protein Sci. 1999)
    10. The structure of human pancreatic alpha-amylase at 1.8-A resolution and comparisons with related enzymes. (PubMed id 8528071)1, 2 Brayer G.D.... Withers S.G. (Protein Sci. 1995)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 279 HGNC: 477 AceView: AMY2A Ensembl:ENSG00000243480 euGenes: HUgn279
    ECgene: AMY2A Kegg: 279 H-InvDB: AMY2A

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for AMY2A Pharmacogenomics, SNPs, Pathways
    Wikipedia http://en.wikipedia.org/wiki/Amylase

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for AMY2A gene:
    Search GeneIP for patents involving AMY2A

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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