 |
 | Services
| |
 |
Aliases & Descriptions for AMY2A
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase) About This Section
|
| Aliases |
|---|
| AMY2 2 | | AMY2B 2 | | EC 3.2.1.1 3 | | OTTHUMP00000012694 2 | | PA 2, 3 | | alpha-amylase 2 | | glycogenase 2 |
| | | Descriptions |
|---|
| 1,4-alpha-D-glucan glucanohydrolase 2, 3 | | amylase, alpha 2A (pancreatic) 2 | | amylase, alpha 2A; pancreatic 1 | | amylase, pancreatic, alpha-2A 2 | | found in the pancreas 2 | | pancreatic amylase 2A 2 | | pancreatic amylase alpha 2A 2 |
|
| | Search outside databases for aliases for AMY2A genePrevious GC identifers: GC01P104824 GC01P103168 GC01P103423 GC01P103871 |
Summaries for AMY2A(According to Entrez Gene,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| EntrezGene summary for AMY2A: Amylases are secreted proteins that hydrolyze 1,4-alpha-glucoside bonds in oligosaccharides and polysaccharides, and thus catalyze the first step in digestion of dietary starch and glycogen. The human genome has a cluster of several amylase genes that are expressed at high levels in either salivary gland or pancreas. This gene encodes an amylase isoenzyme produced by the pancreas. [provided by RefSeq] Gene Wiki entry for AMY2A |
Genomic Location for AMY2A
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to
UCSC and
Ensembl,
Transcription factor binding sites according to
SABiosciences) About This Section
| Genomic View: UCSC Golden Path with GeneCards custom track
Transcription factor binding sites upstream to the AMY2A gene 
Entrez Gene cytogenetic band: 1p21 Ensembl cytogenetic band: 1p21.1 HGNC cytogenetic band: 1p21.1AMY2A Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)
 GeneLoc gene densities for chromosome 1 GeneLoc Exon Structure GeneLoc location for GC01P103961:
(about GC identifiers)
Start:
|
103,960,956 bp from pter |
End:
|
103,969,925 bp from pter |
Size:
|
8,970 bases |
Orientation:
|
plus strand |
RefSeq DNA sequence:- NC_000001.9 NT_019273.18
| Proteins for AMY2A
(According to
1UniProtKB,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Enzo Life Sciences,
Abnova,
OriGene and/or,
Abcam,
Biochemical Assays by
Invitrogen,
Millipore,
R&D Systems,
Cell Signaling Technology, and/or
Enzo Life Sciences,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene,
Antibodies by Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Cell Signaling Technology,
Abcam,
Abnova, and/or
Novus Biologicals)
About This Section
| UniProtKB/Swiss-Prot: AMYP_HUMAN, P04746 (See
protein sequence)Recommended Name: Pancreatic alpha-amylase precursor Size: 511 amino acids; 57707 Da
Cofactor: Binds 1 calcium ion per subunit
Cofactor: Binds 1 chloride ion per subunit
Subunit: Monomer
Subcellular location: Secreted, extracellular space
PDB structures from and Proteopedia :1B2Y (3D)
 1BSI (3D)
 1CPU (3D)
 1HNY (3D)
 1KB3 (3D)
 1KBB (3D)
 1KBK (3D)
 1KGU (3D)
 1KGW (3D)
 1KGX (3D)
 1U2Y (3D)
 1U30 (3D)
 1U33 (3D)
 1XCW (3D)
 1XCX (3D)
 1XD0 (3D)
 1XD1 (3D)
 1XGZ (3D)
 1XH0 (3D)
 1XH1 (3D)
 1XH2 (3D)
 2CPU (3D)
 2QMK (3D)
 2QV4 (3D)
 3BAI (3D)
 3BAJ (3D)
 3BAK (3D)
 3BAW (3D)
 3BAX (3D)
 3BAY (3D)
 3CPU (3D)
 
Secondary accessions: Q9UBH3REFSEQ proteins: NP_000690.1
ENSEMBL proteins: ENSP00000377509 ENSP00000306915
Human Recombinant Proteins Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 
2 Gene Ontology (GO) cellular component terms (links to tree view): About this table
Antibodies for AMY2A: Assays for AMY2A: | Protein
Domains/ Families for AMY2A(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| - Graphical View of Domain Structure for InterPro Entry P04746
ProtoNet protein and cluster: P04746 3 Blocks protein families: IPB006046 Alpha-amylase signature IPB006048 Alpha amylase IPB006589 Alpha amylase
UniProtKB/Swiss-Prot: AMYP_HUMAN, P04746Similarity: Belongs to the glycosyl hydrolase 13 family | Gene Function for AMY2A
(According to MGI Jun 06 2009, UniProtKB,
IUBMB,and/or Genatlas,
shRNA from
OriGene,
Sigma-Aldrich, RNAi from
Sigma-Aldrich,
RNAi Products,
Clones, and
Q-PCR Products
from Invitrogen,
Millipore,
OriGene, and/or
Abnova,
siRNAs from
Applied Biosystems,
SYBR primers from OriGene,
Cell-based Assays from Millipore,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_000699
Applied Biosystems Silencer® siRNAs for AMY2A
Sigma-Aldrich siRNA for AMY2A  Sigma-Aldrich shRNA Panels and shRNA for AMY2A  Explore Sigma-Aldrich super-pooled esiRNAs 
              OriGene GFP tagged cDNA clone in CMV expression vector: NM_000699                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_000699                                  untagged cDNA clone in CMV expression vector: NM_000699 
Primers: Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers               OriGene genome-wide validated SYBR primer pairs: NM_000699
UniProtKB/Swiss-Prot: AMYP_HUMAN, P04746Catalytic activity: Endohydrolysis of (1->4)-alpha-D-glucosidic linkages in oligosaccharides and polysaccharidesEnzyme Number (IUBMB): EC 3.2.1.1 Genatlas biochemistry entry for AMY2A:amylase,alpha-2A,pancreas,see AMY@4 Gene Ontology (GO) molecular function terms (links to tree view): About this table | Pathways & Interactions for AMY2A
(Pathways according to Invitrogen
(maps by GeneGo),
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Proteins Network according to
SABiosciences,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
| 1 Sigma-Aldrich "Your Favorite Gene" Pathway for AMY2A (Your Favorite Gene powered by Ingenuity) 
5/20 Interacting proteins for AMY2A (ENSP000003069153) via UniProtKB, MINT, and/or STRING (see all 20
)About this table
2 Gene Ontology (GO) biological process terms (links to tree view): About this table
|
Drugs & Compounds for AMY2A(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
Browse Tocris compounds for AMY2A
|
Transcripts for AMY2A(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from Invitrogen,
Millipore, and/or
Abnova,
siRNAs from Applied Biosystems,
Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
Tagged/untagged cDNA clones from
OriGene, Expression Assays from Applied Biosystems) About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_000699
Sigma-Aldrich siRNA for AMY2A  Sigma-Aldrich shRNA Panels and shRNA for AMY2A  Explore Sigma-Aldrich super-pooled esiRNAs 
Applied Biosystems Silencer® siRNAs: NM_000699 REFSEQ mRNAs for AMY2A gene: NM_000699.2
Applied Biosystems TaqMan ® Gene Expression Assays: NM_000699               OriGene GFP tagged cDNA clone in CMV expression vector: NM_000699                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_000699                                  untagged cDNA clone in CMV expression vector: NM_000699  Additional cDNA sequence: AK223463.1 BC007060.1 BC146997.1 M28443.1 24/28 DOTS entries (see all 28
): DT.449355 DT.75131378 DT.121339842 DT.40220827 DT.100892344 DT.121339884 DT.121339819 DT.121339952 DT.92061564 DT.100736242 DT.121339828 DT.121339843 DT.92447700 DT.95161677 DT.100753929 DT.100833756 DT.121339827 DT.121339913 DT.121339943 DT.92068068 DT.92447688 DT.92447694 DT.100892335 DT.100892336 24/209 AceView cDNA sequences (see all 209
):BC007060 BM509871 CA950726 BM311500 CA952858 BI438581 BQ268738 BU076711 BG654630 BU949946 CA772445 BI712603 NM_000699 BQ416642 CA941878 BQ778444 BM352653 CB178559 BG654735 BU072345 CB069238 BU069133 CK821495 BM353682
highest scoring ESTs for AMY2A:AA835245 AK223463 AW873832 BE969678 BE970165 BF197785 BU069111 BU790116 CA772147 CA775277 Unigene Cluster for AMY2A: Amylase, alpha 2A (pancreatic) Hs.654437 [show with all ESTs]Unigene Representative Sequence: NM_000699
GeneLoc Exon Structure
2 Ensembl transcripts including schematic representations: ENST00000393932
ENST00000305882
|
Expression for AMY2A
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Expression Assays from
Applied Biosystems
)
About This Section
| AMY2A expression in normal and diseased human tissues
Applied Biosystems TaqMan ® Gene Expression Assays for AMY2A
1 / 2 / 3 3 probe-sets matching AMY2A gene Data from
(Publications) and GNF BioGPS About these images About these images
CGAP SAGE TAG: --
SOURCE GeneReport for Unigene cluster: Hs.654437
|
Orthologs for AMY2A
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for AMY2A gene from 5/9 species (see all 9
)
About this table Species with no ortholog for AMY2A
ENSEMBL Gene Tree for AMY2A | Paralogs for AMY2A(Paralogs according to 1HomoloGene and 2Ensembl, Pseudogenes according to 3Pseudogene.org) About This Section
| Paralogs for AMY2A gene
- AMY1C2 AMY1A2 AMY2B2 AMY1B2
|
SNPs/Variants for AMY2A(According to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Genotyping Reagents from
Applied Biosystems)
About This Section
|
HapMap Linkage Disequilibrium images for AMY2A (up to first 250kb)
|
Disorders & Mutations for AMY2A
(in which this Gene is Involved, According to
OMIM, UniProtKB,
Novoseek, PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
HGMD, GAD,
HuGE Navigator,
BCGD,
and/or TGDB.)
About This Section
|
OMIM: 104650
2 Novoseek disease relationships for AMY2A gene
About this table
Genetic Association Database: AMY2A Human Genome Epidemiology Navigator: AMY2A (3 documents)
|
Medical News for AMY2A(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications for AMY2A (in
PubMed.
Associations of this gene to articles via
1Novoseek,
2HGNC,
3Entrez Gene,
4UniProtKB/Swiss-Prot,
5UniProtKB/TrEMBL,
6GAD, and/or
7PharmGKB)
About This Section
| 10/42 PubMed articles for AMY2A gene (see all 42
):- Human pancreatic amylase is encoded by two different genes. (PubMed id 3260028)2, 3, 4 Groot P.C.... Frants R.R. (1988)
- Population genetic studies of the pancreatic amylase (AMY2, E.C. 3.2.1.1) in Bulgaria. (PubMed id 15571103)1, 3, 6 Baltova S. and Scheil H.G. (2004)
- On the genetic polymorphism of the serum alpha-amylase in the population of the south western Bulgaria (second communication). (PubMed id 16152770)3, 6 Baltova S.D. (2005)
- Phenotype and allele frequencies of some serum protein polymorphisms in populations of the Balkans. (PubMed id 15648851)3, 6 Scheil H.G....Huckenbeck W. (2004)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)3, 4 Gerhard D.S....Malek J. (2004)
- Probing the role of the chloride ion in the mechanism of human pancreatic alpha-amylase. (PubMed id 11772019)3, 4 Numao S....Withers S.G. (2002)
- Mechanistic analyses of catalysis in human pancreatic alpha-amylase: detailed kinetic and structural studies of mutants of three conserved carboxylic acids. (PubMed id 11914097)3, 4 Rydberg E.H....Withers S.G. (2002)
- Subsite mapping of the human pancreatic alpha-amylase active site through structural, kinetic, and mutagenesis techniques. (PubMed id 10769135)3, 4 Brayer G.D.... Withers S.G. (2000)
- Cloning, mutagenesis, and structural analysis of human pancreatic alpha-amylase expressed in Pichia pastoris. (PubMed id 10091666)3, 4 Rydberg E.H....Withers S.G. (1999)
- The structure of human pancreatic alpha-amylase at 1.8-A resolution and comparisons with related enzymes. (PubMed id 8528071)3, 4 Brayer G.D.... Withers S.G. (1995)
|
Search for AMY2A
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
|
|
Genome Databases showing AMY2A
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
and/or
H-InvDB)
About This Section
|
| Other Databases showing AMY2A
(According to HUGE)
About This Section
| -- |
Specialized Databases showing AMY2A(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
|
| Name | Description |
| Wikipedia | http://en.wikipedia.org/wiki/Amylase |
|
| | | About This Section
| --
| Services for AMY2A(Reagents available from Applied Biosystems, Antibodies and assays by Cell
Signaling Technology, Abcam, Novus Biologicals, Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich, Enzo Life Sciences, and/or Tocris Bioscience) About This Section
| 
 Products for AMY2A:

 | |
 | | | | |
|
 |  |  |
| | | | Search Tocris compounds for AMY2A |
|
 |
 | | | |
GeneCards Homepage - Last full update: 2 Jul 2009
Incremental update: 13 Oct 2009
|