Free for academic non-profit institutions. Other users need a Commercial license

Aliases for AMY1C Gene

Aliases for AMY1C Gene

  • Amylase, Alpha 1C (Salivary) 2 3 5
  • 1,4-Alpha-D-Glucan Glucanohydrolase 1 3 4
  • Salivary Alpha-Amylase 3 4
  • EC 4 63
  • AMY1 3 4
  • Amylase, Alpha 1C; Salivary 2
  • Amylase, Salivary, Alpha-1C 3
  • Salivary Amylase Alpha 1C 3
  • Glycogenase 3

External Ids for AMY1C Gene

Previous HGNC Symbols for AMY1C Gene

  • AMY1

Previous GeneCards Identifiers for AMY1C Gene

  • GC01U990009
  • GC01P104093
  • GC01P104292

Summaries for AMY1C Gene

Entrez Gene Summary for AMY1C Gene

  • Amylases are secreted proteins that hydrolyze 1,4-alpha-glucoside bonds in oligosaccharides and polysaccharides, and thus catalyze the first step in digestion of dietary starch and glycogen. The human genome has a cluster of several amylase genes that are expressed at high levels in either salivary gland or pancreas. This gene encodes an amylase isoenzyme produced by the salivary gland. [provided by RefSeq, Jul 2008]

GeneCards Summary for AMY1C Gene

AMY1C (Amylase, Alpha 1C (Salivary)) is a Protein Coding gene. Among its related pathways are Glycosaminoglycan metabolism and Digestion of dietary carbohydrate. GO annotations related to this gene include cation binding and alpha-amylase activity. An important paralog of this gene is AMY2B.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for AMY1C Gene

Genomics for AMY1C Gene

Regulatory Elements for AMY1C Gene

Enhancers for AMY1C Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around AMY1C on UCSC Golden Path with GeneCards custom track

Genomic Location for AMY1C Gene

103,749,656 bp from pter
103,758,692 bp from pter
9,037 bases
Plus strand

Genomic View for AMY1C Gene

Genes around AMY1C on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
AMY1C Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for AMY1C Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for AMY1C Gene

Proteins for AMY1C Gene

  • Protein details for AMY1C Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Alpha-amylase 1
    Protein Accession:
    Secondary Accessions:
    • A6NJS5
    • A8K8H6
    • Q13763
    • Q5T083

    Protein attributes for AMY1C Gene

    511 amino acids
    Molecular mass:
    57768 Da
    Name=Ca(2+); Xref=ChEBI:CHEBI:29108;
    Name=chloride; Xref=ChEBI:CHEBI:17996;
    Quaternary structure:
    • Monomer.
    • Monomer.
    • Monomer.

    Three dimensional structures from OCA and Proteopedia for AMY1C Gene

neXtProt entry for AMY1C Gene

Proteomics data for AMY1C Gene at MOPED

Post-translational modifications for AMY1C Gene

  • Glycosylation at Asn 427 and Asn 476
  • Modification sites at PhosphoSitePlus

Other Protein References for AMY1C Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains & Families for AMY1C Gene

Suggested Antigen Peptide Sequences for AMY1C Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the glycosyl hydrolase 13 family.
  • Belongs to the glycosyl hydrolase 13 family.
genes like me logo Genes that share domains with AMY1C: view

No data available for Gene Families for AMY1C Gene

Function for AMY1C Gene

Molecular function for AMY1C Gene

GENATLAS Biochemistry:
amylase,alpha-1C,salivary,see AMY@
UniProtKB/Swiss-Prot CatalyticActivity:
Endohydrolysis of (1->4)-alpha-D-glucosidic linkages in polysaccharides containing three or more (1->4)-alpha-linked D-glucose units.

Enzyme Numbers (IUBMB) for AMY1C Gene

Gene Ontology (GO) - Molecular Function for AMY1C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 16203048
GO:0043169 cation binding IEA --
genes like me logo Genes that share ontologies with AMY1C: view

Phenotypes for AMY1C Gene

genes like me logo Genes that share phenotypes with AMY1C: view

Animal Model Products

miRNA for AMY1C Gene

miRTarBase miRNAs that target AMY1C

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for AMY1C Gene

Localization for AMY1C Gene

Subcellular locations from UniProtKB/Swiss-Prot for AMY1C Gene

Subcellular locations from

Jensen Localization Image for AMY1C Gene COMPARTMENTS Subcellular localization image for AMY1C gene
Compartment Confidence
extracellular 5

No data available for Gene Ontology (GO) - Cellular Components for AMY1C Gene

Pathways & Interactions for AMY1C Gene

genes like me logo Genes that share pathways with AMY1C: view

Interacting Proteins for AMY1C Gene

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)
Selected Interacting proteins: P04745-AMY1_HUMAN ENSP00000359096 for AMY1C Gene via UniProtKB I2D STRING

Gene Ontology (GO) - Biological Process for AMY1C Gene


No data available for SIGNOR curated interactions for AMY1C Gene

Drugs & Compounds for AMY1C Gene

No Compound Related Data Available

Transcripts for AMY1C Gene

mRNA/cDNA for AMY1C Gene

(2) REFSEQ mRNAs :
(12) Additional mRNA sequences :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for AMY1C Gene

Amylase, alpha 1C (salivary):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for AMY1C Gene

No ASD Table

Relevant External Links for AMY1C Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for AMY1C Gene

mRNA expression in normal human tissues for AMY1C Gene

mRNA differential expression in normal tissues according to GTEx for AMY1C Gene

This gene is overexpressed in Pancreas (x42.2).

Protein differential expression in normal tissues from HIPED for AMY1C Gene

This gene is overexpressed in Saliva (54.0) and Salivary gland (11.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for AMY1C Gene

SOURCE GeneReport for Unigene cluster for AMY1C Gene Hs.655232

genes like me logo Genes that share expression patterns with AMY1C: view

Protein tissue co-expression partners for AMY1C Gene

- Elite partner

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for AMY1C Gene

Orthologs for AMY1C Gene

This gene was present in the common ancestor of animals.

Orthologs for AMY1C Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia AMY1A 35
  • 99.02 (n)
  • 99.02 (a)
(Bos Taurus)
Mammalia -- 36
  • 85 (a)
AMY2B 36
  • 86 (a)
(Canis familiaris)
Mammalia -- 36
  • 88 (a)
-- 36
  • 90 (a)
-- 36
  • 88 (a)
-- 36
  • 90 (a)
-- 36
  • 90 (a)
-- 36
  • 90 (a)
(Monodelphis domestica)
Mammalia -- 36
  • 86 (a)
(Mus musculus)
Mammalia Amy1 36
  • 85 (a)
Amy2a1 36
  • 81 (a)
Amy2a2 36
  • 84 (a)
Amy2a3 36
  • 84 (a)
Amy2a4 36
  • 84 (a)
Amy2a5 36
  • 84 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 84 (a)
(Gallus gallus)
Aves AMY1A 36
  • 79 (a)
AMY2A 36
  • 83 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 80 (a)
(Danio rerio)
Actinopterygii amy2a 36
  • 74 (a)
zgc:66313 36
  • 68 (a)
zgc:92137 36
  • 69 (a)
fruit fly
(Drosophila melanogaster)
Insecta Amy-d 36
  • 55 (a)
Amy-p 36
  • 55 (a)
Amyrel 36
  • 49 (a)
(Caenorhabditis elegans)
Secernentea C50B6.7 36
  • 33 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 54 (a)
Species with no ortholog for AMY1C:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for AMY1C Gene

Gene Tree for AMY1C (if available)
Gene Tree for AMY1C (if available)

Paralogs for AMY1C Gene

Paralogs for AMY1C Gene

(4) SIMAP similar genes for AMY1C Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with AMY1C: view

Variants for AMY1C Gene

Sequence variations from dbSNP and Humsavar for AMY1C Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs4091660 -- 103,756,125(-) caata(C/T)aaata intron-variant
rs11266912 -- 103,750,694(-) TCAGA(A/G)TAGTG intron-variant
rs74667717 -- 103,750,309(+) TTTGA(C/T)GTTCT intron-variant
rs112861460 -- 103,755,245(-) CCATA(C/T)AACTT intron-variant
rs139911862 -- 103,754,584(+) ATGGC(A/G/T)CTGGA reference, missense

Structural Variations from Database of Genomic Variants (DGV) for AMY1C Gene

Variant ID Type Subtype PubMed ID
dgv75e1 CNV Complex 17122850
dgv76e1 CNV Complex 17122850
dgv77e1 CNV Complex 17122850
nsv428157 CNV Gain+Loss 18775914
nsv526367 CNV Gain 19592680
nsv830915 CNV Gain+Loss 17160897
dgv294n71 CNV Gain 21882294
dgv295n71 CNV Gain+Loss 21882294
nsv871791 CNV Loss 21882294
dgv78e1 CNV Complex 17122850
dgv299n71 CNV Gain 21882294
nsv10428 CNV Gain+Loss 18304495
esv23292 CNV Gain+Loss 19812545
nsv870628 CNV Gain 21882294
nsv517215 CNV Gain+Loss 19592680
dgv300n71 CNV Loss 21882294
dgv301n71 CNV Gain+Loss 21882294
nsv2176 CNV Loss 18451855
nsv871973 CNV Loss 21882294
nsv871974 CNV Gain+Loss 21882294
dgv302n71 CNV Loss 21882294
dgv3n14 CNV Loss 18776910
dgv303n71 CNV Gain 21882294
esv1003868 CNV Gain 20482838
esv2715585 CNV Deletion 23290073
nsv483008 CNV Complex 15286789
dgv304n71 CNV Loss 21882294
dgv305n71 CNV Loss 21882294
dgv1n31 CNV Duplication 19718026
nsv871997 CNV Gain 21882294
dgv306n71 CNV Gain 21882294
dgv307n71 CNV Gain+Loss 21882294
dgv308n71 CNV Gain+Loss 21882294
dgv58n67 CNV Gain 20364138
nsv872018 CNV Loss 21882294
dgv309n71 CNV Loss 21882294
nsv469513 CNV Gain 16826518
nsv471677 CNV Gain+Loss 15918152
dgv310n71 CNV Gain 21882294
dgv311n71 CNV Gain+Loss 21882294
nsv511121 CNV Complex 20534489
dgv312n71 CNV Loss 21882294
dgv313n71 CNV Gain 21882294
nsv7179 OTHER Inversion 18451855
dgv314n71 CNV Gain+Loss 21882294
dgv315n71 CNV Gain 21882294
dgv316n71 CNV Loss 21882294
nsv471437 CNV Duplication 19718026
dgv317n71 CNV Loss 21882294
nsv872068 CNV Loss 21882294
nsv872069 CNV Loss 21882294
nsv471346 CNV Duplication 19718026
nsv482059 CNV Gain 20164927
nsv872071 CNV Gain 21882294

Variation tolerance for AMY1C Gene

Gene Damage Index Score: 0.21; 4.69% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for AMY1C Gene

Disorders for AMY1C Gene

Relevant External Links for AMY1C

Genetic Association Database (GAD)
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for AMY1C Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for AMY1C Gene

Publications for AMY1C Gene

  1. Concerted evolution of human amylase genes. (PMID: 2452973) Gumucio D.L. … Meisler M.H. (Mol. Cell. Biol. 1988) 3 4 67
  2. Salivary alpha amylase diurnal pattern and stress response are associated with body mass index in low-income preschool-aged children. (PMID: 25588701) Miller A.L. … Lumeng J.C. (Psychoneuroendocrinology 2015) 3
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  4. Salivary protein profiles are linked to bitter taste acceptance in infants. (PMID: 24248522) Morzel M. … Nicklaus S. (Eur. J. Pediatr. 2014) 3
  5. Proteomic analysis of podocyte exosome-enriched fraction from normal human urine. (PMID: 23376485) Prunotto M. … Moll S. (J Proteomics 2013) 3

Products for AMY1C Gene

Sources for AMY1C Gene