AMY1C Gene
protein-coding GIFtS: 49
GCID: GC01P104292
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amylase, alpha 1C (salivary)(Previous names: amylase, alpha 1C; salivary )
(Previous symbol: AMY1)
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Aliases
for AMY1C gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Amylase, Alpha 1C (Salivary)1 2 | | Amylase, Alpha 1C; Salivary1 | | AMY11 2 3 | | Alpha-Amylase 12 | | Salivary Alpha-Amylase2 3 | | Amylase, Salivary, Alpha-1C2 | | 1,4-Alpha-D-Glucan Glucanohydrolase 12 3 | | Glycogenase1 | | EC 3.2.1.13 8 | | Salivary Amylase Alpha 1C2 |
Export aliases for AMY1C gene to outside databasesPrevious GC identifers: GC01U990009 GC01P104093 |
Summaries
for AMY1C gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for AMY1C:
Amylases are secreted proteins that hydrolyze 1,4-alpha-glucoside bonds in oligosaccharides and polysaccharides, andthus catalyze the first step in digestion of dietary starch and glycogen. The human genome has a cluster of severalamylase genes that are expressed at high levels in either salivary gland or pancreas. This gene encodes an amylaseisoenzyme produced by the salivary gland. (provided by RefSeq, Jul 2008)
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Genomic Views
for AMY1C gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000001.10 NC_018912.1 NT_032977.9
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the AMY1C gene promoter:
TBP RP58 Sox5 Nkx2-2 Brachyury CUTL1 Nkx2-5 RORalpha2 POU2F1 POU2F1a
Other transcription factors
Search SABiosciences Chromatin IP Primers for AMY1C
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat AMY1C |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 1p21 Ensembl cytogenetic band: 1p21.1 HGNC cytogenetic band: 1p21AMY1C Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 1 GeneLoc Exon Structure GeneLoc location for GC01P104292: view genomic region
(about GC identifiers)
Start:
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104,292,441 bp from pter |
End:
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104,301,312 bp from pter |
Size:
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8,872 bases |
Orientation:
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plus strand |
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Proteins
for AMY1C gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: AMY1_HUMAN, P04745 (See
protein sequence)Recommended Name: Alpha-amylase 1 precursor Size: 511 amino acids; 57768 Da
Cofactor: Binds 1 calcium ion per subunit
Cofactor: Binds 1 chloride ion per subunit
Subunit: Monomer
Subcellular location: Secreted
6/13 PDB 3D structures from  and Proteopedia  for AMY1C (see all 13):1C8Q (3D)
1JXJ (3D)
1JXK (3D)
1MFU (3D)
1MFV (3D)
1NM9 (3D)
Secondary accessions: A6NJS5 A8K8H6 Q13763 Q5T083Explore the universe of human proteins at neXtProt for AMY1C: NX_P04745
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_P04745
4/22 DME Specific Peptides for AMY1C (P04745) (see all 22)
AMY1C Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_001008220.1
ENSEMBL proteins: ENSP00000359096 Reactome Protein details: P04745
Human Recombinant Protein Products for AMY1C:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005576 | extracellular region |
IEA | -- |
AMY1C for ontologies About GeneDecksing
AMY1C Antibody Products:
Assay Products for AMY1C: |
Protein
Domains /
Families
for AMY1C gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
AMY1C for domains About GeneDecksing
5/8 InterPro domains/families (see all 8):Graphical View of Domain Structure for InterPro Entry P04745ProtoNet protein and cluster: P04745 3 Blocks protein families: IPB006046 Alpha-amylase signature IPB006048 Alpha amylase IPB006589 Alpha amylase
UniProtKB/Swiss-Prot: AMY1_HUMAN, P04745Similarity: Belongs to the glycosyl hydrolase 13 family |
Function
for AMY1C gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Molecular Function:
UniProtKB/Swiss-Prot Summary: AMY1_HUMAN, P04745Catalytic activity: Endohydrolysis of (1->4)-alpha-D-glucosidic linkages in polysaccharides containing three or more(1->4)-alpha-linked D-glucose units Genatlas biochemistry entry for AMY1C:amylase,alpha-1C,salivary,see AMY@
Enzyme Number (IUBMB): EC 3.2.1.11 2
Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view): About this table
AMY1C for ontologies About GeneDecksing
Animal Models:
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for AMY1C
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for AMY1C
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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| |  | GenScript: all cDNA clones in your preferred vector: AMY1C (NM_001008219) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for AMY1C | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat AMY1C |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for AMY1C |
|
Pathways & Interactions
for AMY1C gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
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Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Carbohydrate digestion and absorption | | | 2 | Glucuronidation | | | 3 | Metabolism | | | 4 | Gastric acid secretion | |
Pathway sources
See GeneCards unified pathways
Show all pathways
3 
Reactome Pathways for AMY1C
4 
Kegg Pathways (Kegg details for AMY1C):
AMY1C for pathways About GeneDecksing
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for AMY1C
STRING Interaction
Network Preview (showing 1 interactants - click image to see more details)
5/11 Interacting proteins for AMY1C (P047451, 3 ENSP000003590964) via UniProtKB, MINT, STRING, and/or I2D (see all 11)About this table
Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table
AMY1C for ontologies About GeneDecksing
|
Drugs & Compounds
for AMY1C gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for AMY1C
Search CenterWatch for drugs/clinical trials and news about AMY1C / AMY1
|
Transcripts
for AMY1C gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for AMY1C gene: NM_001008219.1 Unigene Cluster for AMY1C: Amylase, alpha 1C (salivary) Hs.655232 [show with all ESTs]Unigene Representative Sequence: NM_0040381 Ensembl transcript including schematic representation, and UCSC links where relevant: ENST00000370079(uc001duy.3 uc001duz.3)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for AMY1C
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for AMY1C
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: AMY1C (NM_001008219) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for AMY1C | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat AMY1C |
Additional cDNA sequence: AK292341.1 AK313275.1 BC063129.1 BC069347.1 BC069463.1 BC070302.1 BC092444.1 BC132985.1 BC132987.1 BC132995.1 BC132997.1 BC144452.1 24/26 DOTS entries (see all 26): DT.100892344 DT.449355 DT.100753929 DT.95161677 DT.100685110 DT.121339825 DT.121339826 DT.121339910 DT.121339927 DT.75131378 DT.100892342 DT.121339828 DT.121339943 DT.92447694 DT.121339884 DT.92061564 DT.100844046 DT.121339819 DT.121339847 DT.121339887 DT.121339952 DT.92447700 DT.100736242 DT.121339951
GeneLoc Exon Structure
|
Expression
for AMY1C gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| AMY1C expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --
About this image
See AMY1C Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for AMY1C
SOURCE GeneReport for Unigene cluster: Hs.655232
SABiosciences Custom PCR Arrays for AMY1C
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for AMY1C
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat AMY1C | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat AMY1C | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat AMY1C | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for AMY1C |
Orthologs
for AMY1C gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for AMY1C gene from 5/17 species (see all 17) About this table
ENSEMBL Gene Tree for AMY1C (if available)
TreeFam Gene Tree for AMY1C (if available) |
Paralogs
for AMY1C gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for AMY1C gene
- AMY1A1 2 AMY1B1 2 AMY2A2 AMY2B2
4 SIMAP similar genes for AMY1C using alignment to 1 protein entry: AMY1_HUMAN:AMY1B AMY1A AMY2B AMY2A
AMY1C for paralogs About GeneDecksing
|
Genomic Variants
for AMY1C gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 1 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for AMY1C (104292441 - 104301312 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 17 variations for AMY1C
15/16 CNVs (see all 16): 69238 69229 0012 3302 0681 30393 2048 84396 48067 48068 74585 84395 69236 31636 4238
1 Inversion: 37075 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing AMY1C |
|
Disorders
/ Diseases
for AMY1C gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
AMY1C for disorders About GeneDecksing
OMIM gene information: 104702
OMIM disorders: --
8  diseases for AMY1C: About MalaCardsovarian serous cystadenocarcinoma serous cystadenocarcinoma dental caries sialadenitis
mucoepidermoid carcinoma cystadenocarcinoma pancreatitis carcinoma
Export disorders for AMY1C gene to outside databases
|
Publications
for AMY1C gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for AMY1C gene, integrated from 9 sources (see all 22):
(articles sorted by number of sources associating them with AMY1C) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Concerted evolution of human amylase genes. (PubMed id 2452973)1, 2 Gumucio D.L....Meisler M.H. (1988)
- Primary structure of human salivary alpha-amylase gene. (PubMed id 2423416)1, 2 Nishide T....Matsubara K. (1986)
- Proliferating cell nuclear antigen (PCNA)-associated KIAA0101/PAF15 protein is a cell cycle-regulated anaphase-promoting complex/cyc losome substrate. (PubMed id 21628590)1 Emanuele M.J....Elledge S.J. (2011)
- Large-scale mapping of human protein-protein interactions by mass spectrometry. (PubMed id 17353931)1 Ewing R.M.... Figeys D. (2007)
- The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)2 Gregory S.G.... Bentley D.R. (2006)
- Identification of N-linked glycoproteins in human saliva by glycoprotein capture and mass spectrometry. (PubMed id 16740002)2 Ramachandran P....Loo J.A. (2006)
- Two-hybrid analysis of human salivary mucin MUC7 interactions. (PubMed id 16203048)1 Bruno L.S....Offner G.D. (2005)
- Detection of large-scale variation in the human genome. (PubMed id 15286789)1 Iafrate A.J....Lee C. (2004)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)2 Ota T.... Sugano S. (2004)
|
External Searches for AMY1C gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing AMY1C gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing AMY1C gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing AMY1C gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for AMY1C | Pharmacogenomics, SNPs, Pathways | | Wikipedia | http://en.wikipedia.org/wiki/Amylase |
|
| | |
About This Section
| Patent Information for AMY1C gene:
Search GeneIP for patents involving AMY1C
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for AMY1C gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section
|
 | |
 | |
 |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat AMY1C | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing AMY1C | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat AMY1C | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat AMY1C | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat AMY1C | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat AMY1C |
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| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for AMY1C |
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