Aliases for AMY1C Gene
Aliases for AMY1C Gene
External Ids for AMY1C Gene
- HGNC: 476
- Entrez Gene: 278
- Ensembl: ENSG00000187733
- OMIM: 104702
- UniProtKB: P04745
Previous HGNC Symbols for AMY1C Gene
- AMY1
Previous GeneCards Identifiers for AMY1C Gene
- GC01U990009
- GC01P104093
- GC01P104292
Summaries for AMY1C Gene
-
Amylases are secreted proteins that hydrolyze 1,4-alpha-glucoside bonds in oligosaccharides and polysaccharides, and thus catalyze the first step in digestion of dietary starch and glycogen. The human genome has a cluster of several amylase genes that are expressed at high levels in either salivary gland or pancreas. This gene encodes an amylase isoenzyme produced by the salivary gland. [provided by RefSeq, Jul 2008]
GeneCards Summary for AMY1C Gene
AMY1C (Amylase, Alpha 1C (Salivary)) is a Protein Coding gene. Diseases associated with AMY1C include Avoidant Personality Disorder. Among its related pathways are Digestion of dietary carbohydrate and Carbohydrate digestion and absorption. GO annotations related to this gene include cation binding and alpha-amylase activity. An important paralog of this gene is AMY1A.
No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for AMY1C Gene
Genomics for AMY1C Gene
Regulatory Elements for AMY1C Gene
Regulatory Element Products
Genomic Location for AMY1C Gene
- Chromosome:
- 1
- Start:
- 103,749,656 bp from pter
- End:
- 103,758,692 bp from pter
- Size:
- 9,037 bases
- Orientation:
- Plus strand
Genomic View for AMY1C Gene
Genes around AMY1C on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 1p21.1 by Ensembl
- 1p21.1 by Entrez Gene
- 1p21.1 by HGNC
AMY1C Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for AMY1C Gene
Proteins for AMY1C Gene
-
Protein details for AMY1C Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P04745-AMY1_HUMAN
- Recommended name:
- Alpha-amylase 1
- Protein Accession:
- P04745
- A6NJS5
- A8K8H6
- Q13763
- Q5T083
Protein attributes for AMY1C Gene
- Size:
- 511 amino acids
- Molecular mass:
- 57768 Da
- Cofactor:
- Name=Ca(2+); Xref=ChEBI:CHEBI:29108;
- Cofactor:
- Name=chloride; Xref=ChEBI:CHEBI:17996;
- Quaternary structure:
-
- Monomer.
- Monomer.
- Monomer.
Protein Expression for AMY1C Gene
Selected DME Specific Peptides for AMY1C Gene
- P04745:
-
- LPAGTYCDV
- SILTFWDAR
- RVTEFKYGAKLGTVIRKWNGEKM
- YMNHLID
- GVRIYVD
- AHFSISNS
- QEVIDLGGE
- DNHDNQR
- GEKMSYLKNWGEGWG
- RPWWERYQP
- IVFNNDDW
- CEHRWRQ
- GFCWAQY
- FMLAHPYG
- YCDVISG
- SNQVAFGRG
- GFIVFNN
- PAVPYSGWDFNDGKC
- FRNVVDG
- LDKLHNLN
- AEDPFIAIH
- QVRDCRL
Post-translational modifications for AMY1C Gene
Other Protein References for AMY1C Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- Novus Biologicals Antibodies for AMY1C
-
Abcam antibodies for AMY1C
-
Cloud-Clone Corp. Antibodies for AMY1C
- antibodies-online Antibodies for AMY1C: See all 6
- GeneTex AMY1C antibody for AMY1C
Protein Products
-
OriGene Purified Proteins for AMY1C
- Search Origene for MassSpec and Protein Over-expression Lysates for AMY1C
- Origene Custom Protein Services for AMY1C
-
Cloud-Clone Corp. Proteins for AMY1C
- antibodies-online Proteins for AMY1C: See all 10
- Search antibodies-online for peptides
- Search GeneTex for Proteins for AMY1C
-
Abcam proteins for AMY1C
Domains & Families for AMY1C Gene
Protein Domains for AMY1C Gene
Suggested Antigen Peptide Sequences for AMY1C Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
P04745- Family:
-
- Belongs to the glycosyl hydrolase 13 family.
No data available for Gene Families for AMY1C Gene
Function for AMY1C Gene
Molecular function for AMY1C Gene
- GENATLAS Biochemistry:
- amylase,alpha-1C,salivary,see AMY@
- UniProtKB/Swiss-Prot CatalyticActivity:
- Endohydrolysis of (1->4)-alpha-D-glucosidic linkages in polysaccharides containing three or more (1->4)-alpha-linked D-glucose units.
Enzyme Numbers (IUBMB) for AMY1C Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0004556 | alpha-amylase activity | IEA,TAS | -- |
| GO:0005515 | protein binding | IPI | 16203048 |
| GO:0016787 | hydrolase activity | IEA | -- |
| GO:0016798 | hydrolase activity, acting on glycosyl bonds | IEA | -- |
| GO:0043169 | cation binding | IEA | -- |
Phenotypes for AMY1C Gene
- GenomeRNAi human phenotypes for AMY1C:
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
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-
-
ViGene Biosciences lentiviral particle packaged cDNA for AMY1C gene
-
ViGene Biosciences ready-to-package AAV shRNAs for AMY1C gene
- Search ViGene Biosciences for AMY1C
CRISPR Products
-
OriGene CRISPR knockouts for AMY1C
-
Santa Cruz Biotechnology (SCBT) CRISPR for AMY1C
- GenScript: Design CRISPR guide RNA sequences for AMY1C
miRNA for AMY1C Gene
- miRTarBase miRNAs that target AMY1C
miRNA Products
- Search ViGene Biosciences for AMY1C
Inhibitory RNA Products
- Origene RNAi, siRNA, and shRNA products in human, mouse, rat for AMY1C
- Browse OriGene Inhibitory RNA Products For AMY1C
-
ViGene Biosciences ready-to-package AAV shRNAs for AMY1C gene
Clone Products
-
OriGene ORF clones in human for AMY1C
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- VectorBuilder custom plasmid, inducible vectors for AMY1C
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for AMY1C
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Cell Line Products
-
Horizon Cell Lines for AMY1C
-
ViGene Biosciences adenoviral particle packaged cDNA for AMY1C gene
-
ViGene Biosciences lentiviral particle packaged cDNA for AMY1C gene
-
ViGene Biosciences ready-to-package AAV shRNAs for AMY1C gene
Flow Cytometry Products
No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for AMY1C Gene
Localization for AMY1C Gene
Subcellular locations from UniProtKB/Swiss-Prot for AMY1C Gene
| Compartment | Confidence |
|---|---|
| extracellular | 5 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005576 | extracellular region | IEA | -- |
| GO:0005615 | extracellular space | IDA | 16502470 |
| GO:0070062 | extracellular exosome | IDA | 19199708 |
Pathways & Interactions for AMY1C Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Metabolism |
.37
|
|
| 2 | Carbohydrate digestion and absorption | ||
| 3 | Salivary secretion | ||
| 4 | Galactose metabolism | ||
| 5 | Digestion of dietary carbohydrate | ||
Pathways by source for AMY1C Gene
3 Reactome pathways for AMY1C Gene
4 KEGG pathways for AMY1C Gene
Interacting Proteins for AMY1C Gene
Selected Interacting proteins:
P04745-AMY1_HUMAN
ENSP00000359096
for AMY1C Gene via
UniProtKB
STRING
IID
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005975 | carbohydrate metabolic process | IEA,TAS | -- |
| GO:0007586 | digestion | TAS | 2423416 |
| GO:0008152 | metabolic process | IEA | -- |
No data available for SIGNOR curated interactions for AMY1C Gene
Transcripts for AMY1C Gene
mRNA/cDNA for AMY1C Gene
- (4) REFSEQ mRNAs :
- (12) Additional mRNA sequences :
- (1) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for AMY1C Gene
CRISPR Products
-
OriGene CRISPR knockouts for AMY1C
-
Santa Cruz Biotechnology (SCBT) CRISPR for AMY1C
- GenScript: Design CRISPR guide RNA sequences for AMY1C
miRNA Products
- Search ViGene Biosciences for AMY1C
Inhibitory RNA Products
- Origene RNAi, siRNA, and shRNA products in human, mouse, rat for AMY1C
- Browse OriGene Inhibitory RNA Products For AMY1C
-
ViGene Biosciences ready-to-package AAV shRNAs for AMY1C gene
Clone Products
-
OriGene ORF clones in human for AMY1C
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for AMY1C
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for AMY1C
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Flow Cytometry Products
Expression for AMY1C Gene
mRNA differential expression in normal tissues according to GTEx for AMY1C Gene
This gene is overexpressed in Pancreas (x42.2).
This gene is overexpressed in Saliva (54.0) and Salivary gland (11.5).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for AMY1C Gene
NURSA nuclear receptor signaling pathways regulating expression of AMY1C Gene:
AMY1CSOURCE GeneReport for Unigene cluster for AMY1C Gene:
Hs.655232Evidence on tissue expression from TISSUES for AMY1C Gene
- Saliva(4.7)
- Pancreas(4.4)
- Thyroid gland(4)
- Adrenal gland(2.5)
- Nervous system(2.3)
Primer Products
-
OriGene qPCR primer pairs for AMY1C
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for AMY1C Gene
Orthologs for AMY1C Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | AMY1A 34 |
|
||
| dog (Canis familiaris) |
Mammalia | -- 35 |
|
ManyToMany | |
| -- 35 |
|
ManyToMany | |||
| -- 35 |
|
ManyToMany | |||
| -- 35 |
|
ManyToMany | |||
| -- 35 |
|
ManyToMany | |||
| -- 35 |
|
ManyToMany | |||
| cow (Bos Taurus) |
Mammalia | AMY2B 35 |
|
ManyToMany | |
| -- 35 |
|
ManyToMany | |||
| oppossum (Monodelphis domestica) |
Mammalia | -- 35 |
|
OneToMany | |
| mouse (Mus musculus) |
Mammalia | Amy1 35 |
|
ManyToMany | |
| Amy2a2 35 |
|
ManyToMany | |||
| Amy2a3 35 |
|
ManyToMany | |||
| Amy2a4 35 |
|
ManyToMany | |||
| Amy2a5 35 |
|
ManyToMany | |||
| Amy2a1 35 |
|
ManyToMany | |||
| platypus (Ornithorhynchus anatinus) |
Mammalia | -- 35 |
|
OneToMany | |
| chicken (Gallus gallus) |
Aves | AMY2A 35 |
|
ManyToMany | |
| AMY1A 35 |
|
ManyToMany | |||
| lizard (Anolis carolinensis) |
Reptilia | -- 35 |
|
OneToMany | |
| zebrafish (Danio rerio) |
Actinopterygii | amy2a 35 |
|
ManyToMany | |
| zgc:92137 35 |
|
ManyToMany | |||
| zgc:66313 35 |
|
ManyToMany | |||
| fruit fly (Drosophila melanogaster) |
Insecta | Amy-d 35 |
|
ManyToMany | |
| Amy-p 35 |
|
ManyToMany | |||
| Amyrel 35 |
|
ManyToMany | |||
| worm (Caenorhabditis elegans) |
Secernentea | C50B6.7 35 |
|
OneToMany | |
| sea squirt (Ciona savignyi) |
Ascidiacea | -- 35 |
|
OneToMany |
- Species where no ortholog for AMY1C was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rat (Rattus norvegicus)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- tropical clawed frog (Silurana tropicalis)
- wheat (Triticum aestivum)
Paralogs for AMY1C Gene
Variants for AMY1C Gene
| SNP ID | Clin | Chr 01 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs1002302238 | -- | 103,755,603(+) | GAAGT(C/G)CGCTA | intron-variant | |
| rs1004948451 | -- | 103,747,560(+) | ATCTT(-/GGTTTGA)GGTCT | intron-variant | |
| rs1008774139 | -- | 103,749,414(+) | GATAT(G/T)CGACA | intron-variant, upstream-variant-2KB | |
| rs1010980411 | -- | 103,754,772(+) | CGAGT(A/G)ATGTC | reference, synonymous-codon | |
| rs1015105309 | -- | 103,756,018(+) | TAGCA(C/T)ATGTC | intron-variant |
Gene Damage Index Score:
0.21;
4.69% of all genes are more intolerant (likely to be disease-causing)
Relevant External Links for AMY1C Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- AMY1C
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for AMY1C Gene
Disorders for AMY1C Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| avoidant personality disorder |
|
|
Search AMY1C in MalaCards
View complete list of genes associated with diseases
Relevant External Links for AMY1C
No data available for UniProtKB/Swiss-Prot and Genatlas for AMY1C Gene
Publications for AMY1C Gene
- Concerted evolution of human amylase genes. (PMID: 2452973) Gumucio D.L. … Meisler M.H. (Mol. Cell. Biol. 1988) 3 4 64
- Primary structure of human salivary alpha-amylase gene. (PMID: 2423416) Nishide T. … Matsubara K. (Gene 1986) 3 4 64
- Salivary alpha amylase diurnal pattern and stress response are associated with body mass index in low-income preschool-aged children. (PMID: 25588701) Miller A.L. … Lumeng J.C. (Psychoneuroendocrinology 2015) 3 64
- The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 64
- Salivary protein profiles are linked to bitter taste acceptance in infants. (PMID: 24248522) Morzel M. … Nicklaus S. (Eur. J. Pediatr. 2014) 3 64
Products for AMY1C Gene
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- Cloud-Clone Corp. Antibodies for AMY1C
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- antibodies-online Antibodies for AMY1C: See all 6
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- Search antibodies-online for peptides
- GeneTex AMY1C antibody for AMY1C
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- ViGene Biosciences adenoviral particle packaged cDNA for AMY1C gene
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- Horizon Cell Lines for AMY1C
- Cyagen custom Knockout/knockin (KOKI) mouse models for AMY1C
- VectorBuilder custom plasmid, inducible vectors for AMY1C
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for AMY1C
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Sources for AMY1C Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) RNAdb
- (29) ASD
- (30) ECgene
- (31) GeneAnnot
- (32) CGAP SAGE
- (33) SOURCE
- (34) HomoloGene
- (35) PanEnsembl
- (36) euGenes
- (37) SGD
- (38) FlyBase
- (39) WormBase
- (40) Pseudogene
- (41) DGV
- (42) dbSNP
- (43) GenAtlas
- (44) GeneTests
- (45) HGMD
- (46) GAD
- (47) LSDB
- (48) BGMUT
- (49) HuGE
- (50) eBioscience
- (51) Atlas
- (52) Cell Signaling Technology
- (53) GenBank
- (54) H-invDB
- (55) HORDE
- (56) HUGE
- (57) IMGT
- (58) Leiden
- (59) MILLIPORE
- (60) miRBase
- (61) DME
- (62) NCBI
- (63) OriGene
- (64) PubMed
- (65) R&D Systems
- (66) TGDB
- (67) Tocris
- (68) Abcam
- (69) Novus
- (70) ProSpec
- (71) Sino Biological
- (72) GenScript
- (73) Qiagen
- (74) Cloud-Clone Corp.
- (75) Enzo Life Sciences
- (76) OCA
- (77) Proteopedia
- (78) MOPED
- (79) SPIRE
- (80) neXtProt
- (81) Reactome
- (82) GeneGo (Thomson Reuters)
- (83) fRNAdb
- (84) DISEASES
- (85) SIMAP
- (86) GenomeRNAi
- (87) LifeMap
- (88) miRTarBase
- (89) MalaCards
- (90) Invitrogen
- (91) BitterDB
- (92) Vector BioLabs
- (93) ESI-BIO
- (94) RefSeq
- (95) BioSystems
- (96) MaxQB
- (97) IUPHAR
- (98) BioGPS
- (99) Illumina
- (100) COMPARTMENTS
- (101) HOMER
- (102) PaxDb
- (103) ApexBio
- (104) Addgene
- (105) antibodies-online
- (106) CYP
- (107) NONCODE
- (108) SwitchGear Genomics
- (109) TreeFam
- (110) PathCards
- (111) GeneReviews
- (112) GeneTex
- (113) Taconic Biosciences
- (114) GTEx
- (115) ProteomicsDB
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- (135) Gene Damage Index
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- (141) ENCODE
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- (143) Horizon
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- (146) Cyagen
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- (148) SNPedia
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- (151) CIViC
- (152) ProteoGenix
- (153) dbSUPER
- (154) TISSUES
- (155) Gene ORGANizer