Aliases for AMY1B Gene
Aliases for AMY1B Gene
External Ids for AMY1B Gene
- HGNC: 475
- Entrez Gene: 277
- Ensembl: ENSG00000174876
- OMIM: 104701
- UniProtKB: P04745
Previous HGNC Symbols for AMY1B Gene
- AMY1
Previous GeneCards Identifiers for AMY1B Gene
- GC01U990008
- GC01M104031
- GC01M104230
Summaries for AMY1B Gene
-
Amylases are secreted proteins that hydrolyze 1,4-alpha-glucoside bonds in oligosaccharides and polysaccharides, and thus catalyze the first step in digestion of dietary starch and glycogen. The human genome has a cluster of several amylase genes that are expressed at high levels in either salivary gland or pancreas. This gene encodes an amylase isoenzyme produced by the salivary gland. [provided by RefSeq, Jul 2008]
GeneCards Summary for AMY1B Gene
AMY1B (Amylase, Alpha 1B (Salivary)) is a Protein Coding gene. Diseases associated with AMY1B include Avoidant Personality Disorder. Among its related pathways are Digestion of dietary carbohydrate and Carbohydrate digestion and absorption. GO annotations related to this gene include cation binding and alpha-amylase activity. An important paralog of this gene is AMY1C.
No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for AMY1B Gene
Genomics for AMY1B Gene
Regulatory Elements for AMY1B Gene
- Transcription factor binding sites by QIAGEN in the AMY1B gene promoter:
Regulatory Element Products
Genomic Location for AMY1B Gene
- Chromosome:
- 1
- Start:
- 103,687,415 bp from pter
- End:
- 103,696,680 bp from pter
- Size:
- 9,266 bases
- Orientation:
- Minus strand
Genomic View for AMY1B Gene
Genes around AMY1B on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 1p21.1 by Ensembl
- 1p21.1 by Entrez Gene
- 1p21.1 by HGNC
AMY1B Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for AMY1B Gene
Proteins for AMY1B Gene
-
Protein details for AMY1B Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P04745-AMY1_HUMAN
- Recommended name:
- Alpha-amylase 1
- Protein Accession:
- P04745
- A6NJS5
- A8K8H6
- Q13763
- Q5T083
Protein attributes for AMY1B Gene
- Size:
- 511 amino acids
- Molecular mass:
- 57768 Da
- Cofactor:
- Name=Ca(2+); Xref=ChEBI:CHEBI:29108;
- Cofactor:
- Name=chloride; Xref=ChEBI:CHEBI:17996;
- Quaternary structure:
-
- Monomer.
- Monomer.
- Monomer.
Protein Expression for AMY1B Gene
Selected DME Specific Peptides for AMY1B Gene
- P04745:
-
- LPAGTYCDV
- SILTFWDAR
- RVTEFKYGAKLGTVIRKWNGEKM
- YMNHLID
- GVRIYVD
- AHFSISNS
- QEVIDLGGE
- DNHDNQR
- GEKMSYLKNWGEGWG
- RPWWERYQP
- IVFNNDDW
- CEHRWRQ
- GFCWAQY
- FMLAHPYG
- YCDVISG
- SNQVAFGRG
- GFIVFNN
- PAVPYSGWDFNDGKC
- FRNVVDG
- LDKLHNLN
- AEDPFIAIH
- QVRDCRL
Post-translational modifications for AMY1B Gene
Other Protein References for AMY1B Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- Novus Biologicals Antibodies for AMY1B
-
Abcam antibodies for AMY1B
-
Cloud-Clone Corp. Antibodies for AMY1B
- antibodies-online Antibodies for AMY1B: See all 4
- Search GeneTex for Antibodies for AMY1B
Protein Products
-
OriGene Purified Proteins for AMY1B
- Search Origene for MassSpec and Protein Over-expression Lysates for AMY1B
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- Novus Biologicals lysates for AMY1B
-
Cloud-Clone Corp. Proteins for AMY1B
- Search GeneTex for Proteins for AMY1B
Assay Products
-
Cloud-Clone Corp Assay Kits for AMY1B
Domains & Families for AMY1B Gene
Protein Domains for AMY1B Gene
Graphical View of Domain Structure for InterPro Entry
P04745- Family:
-
- Belongs to the glycosyl hydrolase 13 family.
No data available for Gene Families and Suggested Antigen Peptide Sequences for AMY1B Gene
Function for AMY1B Gene
Molecular function for AMY1B Gene
- GENATLAS Biochemistry:
- amylase,alpha-1B,salivary,see AMY@
- UniProtKB/Swiss-Prot CatalyticActivity:
- Endohydrolysis of (1->4)-alpha-D-glucosidic linkages in polysaccharides containing three or more (1->4)-alpha-linked D-glucose units.
Enzyme Numbers (IUBMB) for AMY1B Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0004556 | alpha-amylase activity | TAS,IEA | -- |
| GO:0005515 | protein binding | IPI | 16203048 |
| GO:0016787 | hydrolase activity | IEA | -- |
| GO:0016798 | hydrolase activity, acting on glycosyl bonds | IEA | -- |
| GO:0043169 | cation binding | IEA | -- |
Phenotypes for AMY1B Gene
- GenomeRNAi human phenotypes for AMY1B:
Animal Model Products
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-
-
ViGene Biosciences lentiviral particle packaged cDNA for AMY1B gene
-
ViGene Biosciences ready-to-package AAV shRNAs for AMY1B gene
- Search ViGene Biosciences for AMY1B
CRISPR Products
-
OriGene CRISPR knockouts for AMY1B
-
Santa Cruz Biotechnology (SCBT) CRISPR for AMY1B
- GenScript: Design CRISPR guide RNA sequences for AMY1B
miRNA for AMY1B Gene
- miRTarBase miRNAs that target AMY1B
miRNA Products
- Search ViGene Biosciences for AMY1B
Inhibitory RNA Products
- Origene RNAi, siRNA, and shRNA products in human, mouse, rat for AMY1B
- Browse OriGene Inhibitory RNA Products For AMY1B
-
ViGene Biosciences ready-to-package AAV shRNAs for AMY1B gene
Clone Products
-
OriGene ORF clones in human for AMY1B
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- VectorBuilder custom plasmid, inducible vectors for AMY1B
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for AMY1B
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Cell Line Products
-
Horizon Cell Lines for AMY1B
-
ViGene Biosciences adenoviral particle packaged cDNA for AMY1B gene
-
ViGene Biosciences lentiviral particle packaged cDNA for AMY1B gene
-
ViGene Biosciences ready-to-package AAV shRNAs for AMY1B gene
Flow Cytometry Products
No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for AMY1B Gene
Localization for AMY1B Gene
Subcellular locations from UniProtKB/Swiss-Prot for AMY1B Gene
| Compartment | Confidence |
|---|---|
| extracellular | 5 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005576 | extracellular region | IEA | -- |
| GO:0005615 | extracellular space | IDA | 16502470 |
| GO:0070062 | extracellular exosome | IDA | 19199708 |
Pathways & Interactions for AMY1B Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Metabolism |
.37
|
|
| 2 | Carbohydrate digestion and absorption | ||
| 3 | Salivary secretion | ||
| 4 | Galactose metabolism | ||
| 5 | Digestion of dietary carbohydrate | ||
Pathways by source for AMY1B Gene
3 Reactome pathways for AMY1B Gene
4 KEGG pathways for AMY1B Gene
Interacting Proteins for AMY1B Gene
Selected Interacting proteins:
P04745-AMY1_HUMAN
ENSP00000330484
for AMY1B Gene via
IID
STRING
UniProtKB
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005975 | carbohydrate metabolic process | TAS,IEA | -- |
| GO:0007586 | digestion | TAS | 2423416 |
| GO:0008152 | metabolic process | IEA | -- |
No data available for SIGNOR curated interactions for AMY1B Gene
Transcripts for AMY1B Gene
mRNA/cDNA for AMY1B Gene
- (2) REFSEQ mRNAs :
- (5) Ensembl transcripts including schematic representations, and UCSC links where relevant :
CRISPR Products
-
OriGene CRISPR knockouts for AMY1B
-
Santa Cruz Biotechnology (SCBT) CRISPR for AMY1B
- GenScript: Design CRISPR guide RNA sequences for AMY1B
miRNA Products
- Search ViGene Biosciences for AMY1B
Inhibitory RNA Products
- Origene RNAi, siRNA, and shRNA products in human, mouse, rat for AMY1B
- Browse OriGene Inhibitory RNA Products For AMY1B
-
ViGene Biosciences ready-to-package AAV shRNAs for AMY1B gene
Clone Products
-
OriGene ORF clones in human for AMY1B
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- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for AMY1B
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for AMY1B
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Flow Cytometry Products
Expression for AMY1B Gene
mRNA differential expression in normal tissues according to GTEx for AMY1B Gene
This gene is overexpressed in Pancreas (x27.1).
This gene is overexpressed in Saliva (54.0) and Salivary gland (11.5).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for AMY1B Gene
NURSA nuclear receptor signaling pathways regulating expression of AMY1B Gene:
AMY1BEvidence on tissue expression from TISSUES for AMY1B Gene
- Saliva(4.7)
- Thyroid gland(4)
- Adrenal gland(2.5)
- Nervous system(2.3)
- Pancreas(2.2)
Primer Products
-
OriGene qPCR primer pairs for AMY1B
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for AMY1B Gene
Orthologs for AMY1B Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | AMY1A 34 |
|
||
| dog (Canis familiaris) |
Mammalia | -- 35 |
|
ManyToMany | |
| -- 35 |
|
ManyToMany | |||
| -- 35 |
|
ManyToMany | |||
| -- 35 |
|
ManyToMany | |||
| -- 35 |
|
ManyToMany | |||
| -- 35 |
|
ManyToMany | |||
| cow (Bos Taurus) |
Mammalia | AMY2B 35 |
|
ManyToMany | |
| -- 35 |
|
ManyToMany | |||
| oppossum (Monodelphis domestica) |
Mammalia | -- 35 |
|
OneToMany | |
| mouse (Mus musculus) |
Mammalia | Amy1 35 |
|
ManyToMany | |
| Amy2a2 35 |
|
ManyToMany | |||
| Amy2a3 35 |
|
ManyToMany | |||
| Amy2a4 35 |
|
ManyToMany | |||
| Amy2a5 35 |
|
ManyToMany | |||
| Amy2a1 35 |
|
ManyToMany | |||
| platypus (Ornithorhynchus anatinus) |
Mammalia | -- 35 |
|
OneToMany | |
| chicken (Gallus gallus) |
Aves | AMY2A 35 |
|
ManyToMany | |
| AMY1A 35 |
|
ManyToMany | |||
| lizard (Anolis carolinensis) |
Reptilia | -- 35 |
|
OneToMany | |
| zebrafish (Danio rerio) |
Actinopterygii | amy2a 35 |
|
ManyToMany | |
| zgc:92137 35 |
|
ManyToMany | |||
| zgc:66313 35 |
|
ManyToMany | |||
| fruit fly (Drosophila melanogaster) |
Insecta | Amy-d 35 |
|
ManyToMany | |
| Amy-p 35 |
|
ManyToMany | |||
| Amyrel 35 |
|
ManyToMany | |||
| worm (Caenorhabditis elegans) |
Secernentea | C50B6.7 35 |
|
OneToMany | |
| sea squirt (Ciona savignyi) |
Ascidiacea | -- 35 |
|
OneToMany |
- Species where no ortholog for AMY1B was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rat (Rattus norvegicus)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- tropical clawed frog (Silurana tropicalis)
- wheat (Triticum aestivum)
Paralogs for AMY1B Gene
Variants for AMY1B Gene
| SNP ID | Clin | Chr 01 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs1027055250 | -- | 103,690,858(+) | CTATT(C/T)CATAT | intron-variant | |
| rs1055294018 | -- | 103,697,424(+) | GACTC(-/TT)AAGGC | upstream-variant-2KB | |
| rs140294416 | -- | 103,691,525(+) | TCCAG(C/T)GCCAT | reference, missense | |
| rs199554865 | -- | 103,691,341(+) | TACTC(A/G)TGTAA | reference, stop-gained | |
| rs199942481 | -- | 103,695,050(+) | ATTTA(C/T)AGCTA | reference, missense |
Gene Damage Index Score:
0.59;
12.75% of all genes are more intolerant (likely to be disease-causing)
Relevant External Links for AMY1B Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- AMY1B
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for AMY1B Gene
Disorders for AMY1B Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| avoidant personality disorder |
|
|
Search AMY1B in MalaCards
View complete list of genes associated with diseases
Relevant External Links for AMY1B
No data available for UniProtKB/Swiss-Prot and Genatlas for AMY1B Gene
Publications for AMY1B Gene
- On the genetic polymorphism of the serum alpha-amylase in the population of the south western Bulgaria (second communication). (PMID: 16152770) Baltova S.D. (Folia Med (Plovdiv) 2005) 3 46 64
- Concerted evolution of human amylase genes. (PMID: 2452973) Gumucio D.L. … Meisler M.H. (Mol. Cell. Biol. 1988) 3 4 64
- Primary structure of human salivary alpha-amylase gene. (PMID: 2423416) Nishide T. … Matsubara K. (Gene 1986) 3 4 64
- Salivary alpha amylase diurnal pattern and stress response are associated with body mass index in low-income preschool-aged children. (PMID: 25588701) Miller A.L. … Lumeng J.C. (Psychoneuroendocrinology 2015) 3 64
- Salivary protein profiles are linked to bitter taste acceptance in infants. (PMID: 24248522) Morzel M. … Nicklaus S. (Eur. J. Pediatr. 2014) 3 64
Products for AMY1B Gene
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- VectorBuilder custom plasmid, inducible vectors for AMY1B
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- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Sources for AMY1B Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
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- (10) PhosphoSitePlus
- (11) GO
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- (28) RNAdb
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- (30) ECgene
- (31) GeneAnnot
- (32) CGAP SAGE
- (33) SOURCE
- (34) HomoloGene
- (35) PanEnsembl
- (36) euGenes
- (37) SGD
- (38) FlyBase
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- (40) Pseudogene
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- (44) GeneTests
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- (50) eBioscience
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- (71) Sino Biological
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- (73) Qiagen
- (74) Cloud-Clone Corp.
- (75) Enzo Life Sciences
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