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Aliases for AMY1B Gene

Aliases for AMY1B Gene

  • Amylase, Alpha 1B (Salivary) 2 3
  • 1,4-Alpha-D-Glucan Glucanohydrolase 1 3 4
  • Salivary Alpha-Amylase 3 4
  • EC 4 63
  • AMY1 3 4
  • Amylase, Alpha 1B; Salivary 2
  • Amylase, Salivary, Alpha-1B 3
  • Salivary Amylase Alpha 1B 3
  • Glycogenase 3

External Ids for AMY1B Gene

Previous HGNC Symbols for AMY1B Gene

  • AMY1

Previous GeneCards Identifiers for AMY1B Gene

  • GC01U990008
  • GC01M104031
  • GC01M104230

Summaries for AMY1B Gene

Entrez Gene Summary for AMY1B Gene

  • Amylases are secreted proteins that hydrolyze 1,4-alpha-glucoside bonds in oligosaccharides and polysaccharides, and thus catalyze the first step in digestion of dietary starch and glycogen. The human genome has a cluster of several amylase genes that are expressed at high levels in either salivary gland or pancreas. This gene encodes an amylase isoenzyme produced by the salivary gland. [provided by RefSeq, Jul 2008]

GeneCards Summary for AMY1B Gene

AMY1B (Amylase, Alpha 1B (Salivary)) is a Protein Coding gene. Among its related pathways are Metabolism and Glycosaminoglycan metabolism. GO annotations related to this gene include cation binding and alpha-amylase activity. An important paralog of this gene is AMY2B.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for AMY1B Gene

Genomics for AMY1B Gene

Regulatory Elements for AMY1B Gene

Genomic Location for AMY1B Gene

103,687,415 bp from pter
103,696,680 bp from pter
9,266 bases
Minus strand

Genomic View for AMY1B Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for AMY1B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for AMY1B Gene

Proteins for AMY1B Gene

  • Protein details for AMY1B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Alpha-amylase 1
    Protein Accession:
    Secondary Accessions:
    • A6NJS5
    • A8K8H6
    • Q13763
    • Q5T083

    Protein attributes for AMY1B Gene

    511 amino acids
    Molecular mass:
    57768 Da
    Name=Ca(2+); Xref=ChEBI:CHEBI:29108; Note=Binds 1 Ca(2+) ion per subunit.;
    Name=chloride; Xref=ChEBI:CHEBI:17996; Note=Binds 1 Cl(-) ion per subunit.;
    Quaternary structure:
    • Monomer
    • Monomer
    • Monomer

    Three dimensional structures from OCA and Proteopedia for AMY1B Gene

neXtProt entry for AMY1B Gene

Proteomics data for AMY1B Gene at MOPED

Post-translational modifications for AMY1B Gene

  • Glycosylation at Asn 427 and Asn 476
  • Modification sites at PhosphoSitePlus

Other Protein References for AMY1B Gene

Domains & Families for AMY1B Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the glycosyl hydrolase 13 family.
  • Belongs to the glycosyl hydrolase 13 family.
genes like me logo Genes that share domains with AMY1B: view

No data available for Gene Families and Suggested Antigen Peptide Sequences for AMY1B Gene

Function for AMY1B Gene

Molecular function for AMY1B Gene

GENATLAS Biochemistry:
amylase,alpha-1B,salivary,see AMY@
UniProtKB/Swiss-Prot CatalyticActivity:
Endohydrolysis of (1->4)-alpha-D-glucosidic linkages in polysaccharides containing three or more (1->4)-alpha-linked D-glucose units

Enzyme Numbers (IUBMB) for AMY1B Gene

Gene Ontology (GO) - Molecular Function for AMY1B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003824 catalytic activity --
GO:0004556 alpha-amylase activity IEA --
GO:0005515 protein binding IPI 16203048
GO:0043169 cation binding --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with AMY1B: view

Animal Model Products

miRNA for AMY1B Gene

miRTarBase miRNAs that target AMY1B

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for AMY1B

In Situ Assay Products

Flow Cytometry Products

No data available for Phenotypes , Animal Models , Transcription Factor Targets and HOMER Transcription for AMY1B Gene

Localization for AMY1B Gene

Subcellular locations from UniProtKB/Swiss-Prot for AMY1B Gene

Subcellular locations from

Jensen Localization Image for AMY1B Gene COMPARTMENTS Subcellular localization image for AMY1B gene
Compartment Confidence
extracellular 5

Gene Ontology (GO) - Cellular Components for AMY1B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IDA 16502470
GO:0070062 extracellular exosome IDA 19199708
genes like me logo Genes that share ontologies with AMY1B: view

Pathways & Interactions for AMY1B Gene

genes like me logo Genes that share pathways with AMY1B: view

Interacting Proteins for AMY1B Gene

Gene Ontology (GO) - Biological Process for AMY1B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005975 carbohydrate metabolic process IEA --
GO:0007586 digestion TAS 2423416
genes like me logo Genes that share ontologies with AMY1B: view

No data available for SIGNOR curated interactions for AMY1B Gene

Drugs & Compounds for AMY1B Gene

No Compound Related Data Available

Transcripts for AMY1B Gene

mRNA/cDNA for AMY1B Gene

(2) REFSEQ mRNAs :
(5) Ensembl transcripts including schematic representations, and UCSC links where relevant :

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for AMY1B

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for AMY1B Gene

No ASD Table

Relevant External Links for AMY1B Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for AMY1B Gene

mRNA expression in normal human tissues for AMY1B Gene

mRNA differential expression in normal tissues according to GTEx for AMY1B Gene

This gene is overexpressed in Pancreas (x27.1).

Protein differential expression in normal tissues from HIPED for AMY1B Gene

This gene is overexpressed in Saliva (54.0) and Salivary gland (11.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for AMY1B Gene

genes like me logo Genes that share expression patterns with AMY1B: view

Protein tissue co-expression partners for AMY1B Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for AMY1B Gene

Orthologs for AMY1B Gene

This gene was present in the common ancestor of animals.

Orthologs for AMY1B Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia AMY1A 35
  • 99.02 (n)
  • 99.02 (a)
(Bos Taurus)
Mammalia -- 36
  • 85 (a)
AMY2B 36
  • 86 (a)
(Canis familiaris)
Mammalia -- 36
  • 88 (a)
-- 36
  • 90 (a)
-- 36
  • 88 (a)
-- 36
  • 90 (a)
-- 36
  • 90 (a)
-- 36
  • 90 (a)
(Monodelphis domestica)
Mammalia -- 36
  • 86 (a)
(Mus musculus)
Mammalia Amy1 36
  • 85 (a)
Amy2a1 36
  • 81 (a)
Amy2a2 36
  • 84 (a)
Amy2a3 36
  • 84 (a)
Amy2a4 36
  • 84 (a)
Amy2a5 36
  • 84 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 84 (a)
(Gallus gallus)
Aves AMY1A 36
  • 79 (a)
AMY2A 36
  • 83 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 80 (a)
(Danio rerio)
Actinopterygii amy2a 36
  • 74 (a)
zgc:66313 36
  • 68 (a)
zgc:92137 36
  • 69 (a)
fruit fly
(Drosophila melanogaster)
Insecta Amy-d 36
  • 55 (a)
Amy-p 36
  • 55 (a)
Amyrel 36
  • 49 (a)
(Caenorhabditis elegans)
Secernentea C50B6.7 36
  • 33 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 54 (a)
Species with no ortholog for AMY1B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for AMY1B Gene

Gene Tree for AMY1B (if available)
Gene Tree for AMY1B (if available)

Paralogs for AMY1B Gene

Paralogs for AMY1B Gene

(4) SIMAP similar genes for AMY1B Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with AMY1B: view

Variants for AMY1B Gene

Sequence variations from dbSNP and Humsavar for AMY1B Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs462284 -- 103,697,363(-) ggagc(A/G)agaac upstream-variant-2KB
rs2270892 -- 103,693,244(+) TCTGC(C/T)GTGAA intron-variant
rs3870217 -- 103,690,024(+) aaatg(A/G)gaata intron-variant
rs61814736 -- 103,691,346(+) GTGTA(A/T)ATCCA missense, reference
rs61814737 -- 103,694,372(+) CTTGG(C/T)CAAAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for AMY1B Gene

Variant ID Type Subtype PubMed ID
dgv75e1 CNV Complex 17122850
dgv76e1 CNV Complex 17122850
dgv77e1 CNV Complex 17122850
nsv428157 CNV Gain+Loss 18775914
nsv526367 CNV Gain 19592680
nsv830915 CNV Gain+Loss 17160897
dgv294n71 CNV Gain 21882294
dgv295n71 CNV Gain+Loss 21882294
nsv871791 CNV Loss 21882294
dgv78e1 CNV Complex 17122850
dgv299n71 CNV Gain 21882294
nsv10428 CNV Gain+Loss 18304495
esv23292 CNV Gain+Loss 19812545
nsv870628 CNV Gain 21882294
nsv517215 CNV Gain+Loss 19592680
dgv300n71 CNV Loss 21882294
dgv301n71 CNV Gain+Loss 21882294
nsv2176 CNV Loss 18451855
nsv871973 CNV Loss 21882294
nsv871974 CNV Gain+Loss 21882294
dgv302n71 CNV Loss 21882294
dgv3n14 CNV Loss 18776910
dgv303n71 CNV Gain 21882294
esv1003868 CNV Gain 20482838
esv2715585 CNV Deletion 23290073
nsv483008 CNV Complex 15286789
dgv304n71 CNV Loss 21882294
dgv305n71 CNV Loss 21882294
dgv1n31 CNV Duplication 19718026
nsv871997 CNV Gain 21882294
dgv306n71 CNV Gain 21882294
dgv307n71 CNV Gain+Loss 21882294
dgv308n71 CNV Gain+Loss 21882294
dgv58n67 CNV Gain 20364138
nsv872018 CNV Loss 21882294
dgv309n71 CNV Loss 21882294
nsv469513 CNV Gain 16826518
nsv471677 CNV Gain+Loss 15918152
dgv310n71 CNV Gain 21882294
dgv311n71 CNV Gain+Loss 21882294
nsv511121 CNV Complex 20534489
dgv312n71 CNV Loss 21882294
dgv313n71 CNV Gain 21882294
nsv7179 OTHER Inversion 18451855
dgv314n71 CNV Gain+Loss 21882294
dgv315n71 CNV Gain 21882294
dgv316n71 CNV Loss 21882294
nsv471437 CNV Duplication 19718026
dgv317n71 CNV Loss 21882294
nsv872068 CNV Loss 21882294
nsv872069 CNV Loss 21882294
nsv471346 CNV Duplication 19718026
nsv482059 CNV Gain 20164927
nsv872071 CNV Gain 21882294

Variation tolerance for AMY1B Gene

Gene Damage Index Score: 0.59; 12.75% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for AMY1B Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for AMY1B Gene

Disorders for AMY1B Gene

Relevant External Links for AMY1B

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with AMY1B: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for AMY1B Gene

Publications for AMY1B Gene

  1. Salivary protein profiles are linked to bitter taste acceptance in infants. (PMID: 24248522) Morzel M. … Nicklaus S. (Eur. J. Pediatr. 2014) 67
  2. In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine. (PMID: 23533145) Principe S. … Drake R.R. (Proteomics 2013) 67
  3. Proteomic analysis of podocyte exosome-enriched fraction from normal human urine. (PMID: 23376485) Prunotto M. … Moll S. (J Proteomics 2013) 67
  4. Salivary alpha-amylase and cortisol responsiveness following electrical stimulation stress in major depressive disorder patients. (PMID: 22063648) Tanaka Y. … Akiyoshi J. (Prog. Neuropsychopharmacol. Biol. Psychiatry 2012) 67
  5. State and trait variance in salivary I+-amylase: a behavioral genetic study. (PMID: 21827821) Out D. … van Ijzendoorn M.H. (Biol Psychol 2011) 67

Products for AMY1B Gene

Sources for AMY1B Gene

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