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Aliases for AMY1A Gene

Aliases for AMY1A Gene

  • Amylase, Alpha 1A (Salivary) 2 3
  • 1,4-Alpha-D-Glucan Glucanohydrolase 1 3 4
  • Salivary Alpha-Amylase 3 4
  • EC 3.2.1.1 4 63
  • AMY1 3 4
  • Amylase, Alpha 1A; Salivary 2
  • Amylase, Salivary, Alpha-1A 3
  • Salivary Amylase Alpha 1A 3
  • AMY1A AMY1B AMY1C 4
  • Glycogenase 3

External Ids for AMY1A Gene

Previous HGNC Symbols for AMY1A Gene

  • AMY1

Previous GeneCards Identifiers for AMY1A Gene

  • GC01P104923
  • GC01P105126
  • GC01P103252
  • GC01P103647
  • GC01P103553
  • GC01M103942
  • GC01P103999
  • GC01P104197
  • GC01P102238

Summaries for AMY1A Gene

Entrez Gene Summary for AMY1A Gene

  • Amylases are secreted proteins that hydrolyze 1,4-alpha-glucoside bonds in oligosaccharides and polysaccharides, and thus catalyze the first step in digestion of dietary starch and glycogen. The human genome has a cluster of several amylase genes that are expressed at high levels in either salivary gland or pancreas. This gene encodes an amylase isoenzyme produced by the salivary gland. Alternative splicing results in multiple transcript variants encoding the same protein. [provided by RefSeq, Jul 2008]

GeneCards Summary for AMY1A Gene

AMY1A (Amylase, Alpha 1A (Salivary)) is a Protein Coding gene. Diseases associated with AMY1A include developmental coordination disorder. Among its related pathways are Metabolism and Glycosaminoglycan metabolism. GO annotations related to this gene include cation binding and alpha-amylase activity. An important paralog of this gene is AMY2B.

Gene Wiki entry for AMY1A Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for AMY1A Gene

Genomics for AMY1A Gene

Regulatory Elements for AMY1A Gene

Genomic Location for AMY1A Gene

Chromosome:
1
Start:
103,655,290 bp from pter
End:
103,664,554 bp from pter
Size:
9,265 bases
Orientation:
Plus strand

Genomic View for AMY1A Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for AMY1A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for AMY1A Gene

Proteins for AMY1A Gene

  • Protein details for AMY1A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P04745-AMY1_HUMAN
    Recommended name:
    Alpha-amylase 1
    Protein Accession:
    P04745
    Secondary Accessions:
    • A6NJS5
    • A8K8H6
    • Q13763
    • Q5T083

    Protein attributes for AMY1A Gene

    Size:
    511 amino acids
    Molecular mass:
    57768 Da
    Cofactor:
    Name=Ca(2+); Xref=ChEBI:CHEBI:29108; Note=Binds 1 Ca(2+) ion per subunit.;
    Cofactor:
    Name=chloride; Xref=ChEBI:CHEBI:17996; Note=Binds 1 Cl(-) ion per subunit.;
    Quaternary structure:
    • Monomer
    • Monomer
    • Monomer

    Three dimensional structures from OCA and Proteopedia for AMY1A Gene

neXtProt entry for AMY1A Gene

Proteomics data for AMY1A Gene at MOPED

Post-translational modifications for AMY1A Gene

  • Glycosylation at Asn 427 and Asn 476
  • Modification sites at PhosphoSitePlus

Other Protein References for AMY1A Gene

Antibody Products

Domains & Families for AMY1A Gene

Suggested Antigen Peptide Sequences for AMY1A Gene

Graphical View of Domain Structure for InterPro Entry

P04745

UniProtKB/Swiss-Prot:

AMY1_HUMAN :
  • Belongs to the glycosyl hydrolase 13 family.
Family:
  • Belongs to the glycosyl hydrolase 13 family.
genes like me logo Genes that share domains with AMY1A: view

No data available for Gene Families for AMY1A Gene

Function for AMY1A Gene

Molecular function for AMY1A Gene

GENATLAS Biochemistry:
amylase,alpha-1A,salivary,see AMY@
UniProtKB/Swiss-Prot CatalyticActivity:
Endohydrolysis of (1->4)-alpha-D-glucosidic linkages in polysaccharides containing three or more (1->4)-alpha-linked D-glucose units

Enzyme Numbers (IUBMB) for AMY1A Gene

Gene Ontology (GO) - Molecular Function for AMY1A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003824 catalytic activity --
GO:0004556 alpha-amylase activity IEA --
GO:0005515 protein binding IPI 16203048
GO:0043169 cation binding --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with AMY1A: view

Phenotypes for AMY1A Gene

genes like me logo Genes that share phenotypes with AMY1A: view

Animal Model Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for AMY1A

In Situ Assay Products

Flow Cytometry Products

No data available for Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for AMY1A Gene

Localization for AMY1A Gene

Subcellular locations from UniProtKB/Swiss-Prot for AMY1A Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for AMY1A Gene COMPARTMENTS Subcellular localization image for AMY1A gene
Compartment Confidence
extracellular 5

Gene Ontology (GO) - Cellular Components for AMY1A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IDA 16502470
GO:0070062 extracellular exosome IDA 19199708
genes like me logo Genes that share ontologies with AMY1A: view

Pathways & Interactions for AMY1A Gene

genes like me logo Genes that share pathways with AMY1A: view

Gene Ontology (GO) - Biological Process for AMY1A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005975 carbohydrate metabolic process IEA --
GO:0007586 digestion TAS 2423416
genes like me logo Genes that share ontologies with AMY1A: view

No data available for SIGNOR curated interactions for AMY1A Gene

Drugs & Compounds for AMY1A Gene

(8) Drugs for AMY1A Gene - From: HMDB, DrugBank, and NovoSeek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Acarbose Approved, Investigational Pharma Alpha-glucosidase inhibitor 79
Pyroglutamic acid Experimental Pharma Target 0
4,6-Dideoxy-4-Amino-Alpha-D-Glucose Experimental Pharma Target 0
5-Hydroxymethyl-Chonduritol Experimental Pharma Target 0
Beta-D-Glucose Experimental Pharma Target 0

(8) Additional Compounds for AMY1A Gene - From: HMDB and NovoSeek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Alpha-D-Glucose
  • a-D-Glucopyranose
  • a-D-Glucose
  • a-Dextrose
  • a-Glucose
  • alpha-D-Glucopyranose
492-62-6
Chloride ion
  • Bertholite
  • Chloor
  • Chlor
  • Chlore
  • Chloride
16887-00-6
Dextrin
  • British gum
  • Caloreen
  • Corn dextrin
  • Crystal gum
  • Dextrid
9004-53-9
Glycogen
  • Animal starch
  • Glycogen
  • Liver starch
  • Lyoglycogen
  • Phytoglycogen
9005-79-2
Water
  • Dihydrogen oxide
  • Steam
7732-18-5
genes like me logo Genes that share compounds with AMY1A: view

Transcripts for AMY1A Gene

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for AMY1A

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for AMY1A Gene

No ASD Table

Relevant External Links for AMY1A Gene

GeneLoc Exon Structure for
AMY1A
ECgene alternative splicing isoforms for
AMY1A

Expression for AMY1A Gene

mRNA expression in normal human tissues for AMY1A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for AMY1A Gene

This gene is overexpressed in Pancreas (x44.7).

Protein differential expression in normal tissues from HIPED for AMY1A Gene

This gene is overexpressed in Saliva (54.0) and Salivary gland (11.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for AMY1A Gene



genes like me logo Genes that share expression patterns with AMY1A: view

Protein tissue co-expression partners for AMY1A Gene

- Elite partner

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for AMY1A Gene

Orthologs for AMY1A Gene

This gene was present in the common ancestor of animals.

Orthologs for AMY1A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia AMY1A 35
  • 99.02 (n)
  • 99.02 (a)
mouse
(Mus musculus)
Mammalia Amy1 16
Amy1 36
  • 85 (a)
ManyToMany
Amy2a1 36
  • 81 (a)
ManyToMany
Amy2a2 36
  • 84 (a)
ManyToMany
Amy2a3 36
  • 84 (a)
ManyToMany
Amy2a4 36
  • 84 (a)
ManyToMany
Amy2a5 36
  • 84 (a)
ManyToMany
cow
(Bos Taurus)
Mammalia -- 36
  • 85 (a)
ManyToMany
AMY2B 36
  • 86 (a)
ManyToMany
dog
(Canis familiaris)
Mammalia -- 36
  • 88 (a)
ManyToMany
-- 36
  • 90 (a)
ManyToMany
-- 36
  • 88 (a)
ManyToMany
-- 36
  • 90 (a)
ManyToMany
-- 36
  • 90 (a)
ManyToMany
-- 36
  • 90 (a)
ManyToMany
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 86 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 84 (a)
OneToMany
chicken
(Gallus gallus)
Aves AMY1A 36
  • 79 (a)
ManyToMany
AMY2A 36
  • 83 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 80 (a)
OneToMany
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.8384 35
zebrafish
(Danio rerio)
Actinopterygii amy2a 36
  • 74 (a)
ManyToMany
zgc:66313 36
  • 68 (a)
ManyToMany
zgc:92137 36
  • 69 (a)
ManyToMany
fruit fly
(Drosophila melanogaster)
Insecta Amy-d 37
  • 52 (a)
Amy-p 37
  • 52 (a)
Amyrel 37
  • 48 (a)
Amy-d 36
  • 55 (a)
ManyToMany
Amy-p 36
  • 55 (a)
ManyToMany
Amyrel 36
  • 49 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea C50B6.7 37
  • 44 (a)
C50B6.7 36
  • 33 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 54 (a)
OneToMany
Species with no ortholog for AMY1A:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for AMY1A Gene

ENSEMBL:
Gene Tree for AMY1A (if available)
TreeFam:
Gene Tree for AMY1A (if available)

Paralogs for AMY1A Gene

Paralogs for AMY1A Gene

(4) SIMAP similar genes for AMY1A Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with AMY1A: view

Variants for AMY1A Gene

Sequence variations from dbSNP and Humsavar for AMY1A Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs781432273 -- 103,660,463(+) CTATA(A/C)TTACC missense, reference
rs780631463 -- 103,660,374(+) AGAAG(A/G)TTGGG missense, reference
rs780356703 -- 103,660,586(+) TACAA(A/C)ATGGC reference, missense
rs780338220 -- 103,660,506(+) TATTT(G/T)TTTAA intron-variant
rs779990035 -- 103,660,448(+) GCGCT(A/G)GAGGA missense, reference

Structural Variations from Database of Genomic Variants (DGV) for AMY1A Gene

Variant ID Type Subtype PubMed ID
dgv75e1 CNV Complex 17122850
dgv76e1 CNV Complex 17122850
dgv77e1 CNV Complex 17122850
nsv428157 CNV Gain+Loss 18775914
nsv526367 CNV Gain 19592680
nsv830915 CNV Gain+Loss 17160897
dgv294n71 CNV Gain 21882294
dgv295n71 CNV Gain+Loss 21882294
nsv871791 CNV Loss 21882294
dgv78e1 CNV Complex 17122850
dgv299n71 CNV Gain 21882294
nsv10428 CNV Gain+Loss 18304495
esv23292 CNV Gain+Loss 19812545
nsv870628 CNV Gain 21882294
nsv517215 CNV Gain+Loss 19592680
dgv300n71 CNV Loss 21882294
dgv301n71 CNV Gain+Loss 21882294
nsv2176 CNV Loss 18451855
nsv871973 CNV Loss 21882294
nsv871974 CNV Gain+Loss 21882294
dgv302n71 CNV Loss 21882294
dgv3n14 CNV Loss 18776910
dgv303n71 CNV Gain 21882294
esv1003868 CNV Gain 20482838
esv2715585 CNV Deletion 23290073
nsv483008 CNV Complex 15286789
dgv304n71 CNV Loss 21882294
dgv305n71 CNV Loss 21882294
dgv1n31 CNV Duplication 19718026
nsv871997 CNV Gain 21882294
dgv306n71 CNV Gain 21882294
dgv307n71 CNV Gain+Loss 21882294
dgv308n71 CNV Gain+Loss 21882294
dgv58n67 CNV Gain 20364138
nsv872018 CNV Loss 21882294
dgv309n71 CNV Loss 21882294
nsv469513 CNV Gain 16826518
nsv471677 CNV Gain+Loss 15918152
dgv310n71 CNV Gain 21882294
dgv311n71 CNV Gain+Loss 21882294
nsv511121 CNV Complex 20534489
dgv312n71 CNV Loss 21882294
dgv313n71 CNV Gain 21882294
nsv7179 OTHER Inversion 18451855
dgv314n71 CNV Gain+Loss 21882294
dgv315n71 CNV Gain 21882294
dgv316n71 CNV Loss 21882294
nsv471437 CNV Duplication 19718026
dgv317n71 CNV Loss 21882294
nsv872068 CNV Loss 21882294
nsv872069 CNV Loss 21882294
nsv471346 CNV Duplication 19718026
nsv482059 CNV Gain 20164927
nsv872071 CNV Gain 21882294

Variation tolerance for AMY1A Gene

Gene Damage Index Score: 0.21; 4.63% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for AMY1A Gene

HapMap Linkage Disequilibrium report
AMY1A
Human Gene Mutation Database (HGMD)
AMY1A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for AMY1A Gene

Disorders for AMY1A Gene

MalaCards: The human disease database

(1) MalaCards diseases for AMY1A Gene - From: DISEASES

Disorder Aliases PubMed IDs
developmental coordination disorder
  • motor skills disorders
- elite association
Search AMY1A in MalaCards View complete list of genes associated with diseases

Relevant External Links for AMY1A

Genetic Association Database (GAD)
AMY1A
Human Genome Epidemiology (HuGE) Navigator
AMY1A
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
AMY1A
genes like me logo Genes that share disorders with AMY1A: view

No data available for UniProtKB/Swiss-Prot and Genatlas for AMY1A Gene

Publications for AMY1A Gene

  1. Two secondary carbohydrate binding sites on the surface of barley alpha-amylase 1 have distinct functions and display synergy in hydrolysis of starch granules. (PMID: 19606835) Nielsen M.M. … Svensson B. (Biochemistry 2009) 23 67
  2. Effects of calcium ion concentration on starch hydrolysis of barley alpha-amylase isozymes. (PMID: 18467868) Yuk J.B. … Kim T.J. (J. Microbiol. Biotechnol. 2008) 23 67
  3. Diet and the evolution of human amylase gene copy number variation. (PMID: 17828263) Perry G.H. … Stone A.C. (Nat. Genet. 2007) 23 67
  4. How many drug targets are there? (PMID: 17139284) Overington J.P. … Hopkins A.L. (Nat Rev Drug Discov 2006) 25 26
  5. Drugs, their targets and the nature and number of drug targets. (PMID: 17016423) Imming P. … Meyer A. (Nat Rev Drug Discov 2006) 25 26

Products for AMY1A Gene

Sources for AMY1A Gene

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