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Aliases for AMY1A Gene

Aliases for AMY1A Gene

  • Amylase, Alpha 1A (Salivary) 2 3
  • 1,4-Alpha-D-Glucan Glucanohydrolase 1 3 4
  • Salivary Alpha-Amylase 3 4
  • EC 4 63
  • AMY1 3 4
  • Amylase, Alpha 1A; Salivary 2
  • Amylase, Salivary, Alpha-1A 3
  • Salivary Amylase Alpha 1A 3
  • Alpha-Amylase 1 3
  • Glycogenase 3

External Ids for AMY1A Gene

Previous HGNC Symbols for AMY1A Gene

  • AMY1

Previous GeneCards Identifiers for AMY1A Gene

  • GC01P104923
  • GC01P105126
  • GC01P103252
  • GC01P103647
  • GC01P103553
  • GC01M103942
  • GC01P103999
  • GC01P104197
  • GC01P102238

Summaries for AMY1A Gene

Entrez Gene Summary for AMY1A Gene

  • Amylases are secreted proteins that hydrolyze 1,4-alpha-glucoside bonds in oligosaccharides and polysaccharides, and thus catalyze the first step in digestion of dietary starch and glycogen. The human genome has a cluster of several amylase genes that are expressed at high levels in either salivary gland or pancreas. This gene encodes an amylase isoenzyme produced by the salivary gland. Alternative splicing results in multiple transcript variants encoding the same protein. [provided by RefSeq, Jul 2008]

GeneCards Summary for AMY1A Gene

AMY1A (Amylase, Alpha 1A (Salivary)) is a Protein Coding gene. Among its related pathways are Metabolism and Metabolism. An important paralog of this gene is AMY2B.

Gene Wiki entry for AMY1A Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for AMY1A Gene

Genomics for AMY1A Gene

Regulatory Elements for AMY1A Gene

Genomic Location for AMY1A Gene

103,651,199 bp from pter
103,752,946 bp from pter
101,748 bases
Plus strand

Genomic View for AMY1A Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for AMY1A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for AMY1A Gene

Proteins for AMY1A Gene

  • Protein details for AMY1A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Alpha-amylase 1
    Protein Accession:
    Secondary Accessions:
    • A6NJS5
    • A8K8H6
    • Q13763
    • Q5T083

    Protein attributes for AMY1A Gene

    511 amino acids
    Molecular mass:
    57768 Da
    Name=Ca(2+); Xref=ChEBI:CHEBI:29108; Note=Binds 1 Ca(2+) ion per subunit.;
    Name=chloride; Xref=ChEBI:CHEBI:17996; Note=Binds 1 Cl(-) ion per subunit.;
    Quaternary structure:
    • Monomer

    Three dimensional structures from OCA and Proteopedia for AMY1A Gene

neXtProt entry for AMY1A Gene

Proteomics data for AMY1A Gene at MOPED

Post-translational modifications for AMY1A Gene

  • Glycosylation at Asn427 and Asn476
  • Modification sites at PhosphoSitePlus

Other Protein References for AMY1A Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Domains for AMY1A Gene

Suggested Antigen Peptide Sequences for AMY1A Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the glycosyl hydrolase 13 family.
  • Belongs to the glycosyl hydrolase 13 family.
genes like me logo Genes that share domains with AMY1A: view

No data available for Gene Families for AMY1A Gene

Function for AMY1A Gene

Molecular function for AMY1A Gene

GENATLAS Biochemistry:
amylase,alpha-1A,salivary,see AMY@
UniProtKB/Swiss-Prot CatalyticActivity:
Endohydrolysis of (1->4)-alpha-D-glucosidic linkages in polysaccharides containing three or more (1->4)-alpha-linked D-glucose units

Enzyme Numbers (IUBMB) for AMY1A Gene

Gene Ontology (GO) - Molecular Function for AMY1A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003824 catalytic activity --
GO:0004556 alpha-amylase activity IEA --
GO:0005515 protein binding IPI 16203048
GO:0043169 cation binding --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with AMY1A: view

Animal Model Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for AMY1A

In Situ Assay Products

Flow Cytometry Products

No data available for Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for AMY1A Gene

Localization for AMY1A Gene

Subcellular locations from UniProtKB/Swiss-Prot for AMY1A Gene


Subcellular locations from

Jensen Localization Image for AMY1A Gene COMPARTMENTS Subcellular localization image for AMY1A gene
Compartment Confidence
extracellular 5
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for AMY1A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IDA 16502470
GO:0070062 extracellular exosome IDA 19199708
genes like me logo Genes that share ontologies with AMY1A: view

Pathways for AMY1A Gene

genes like me logo Genes that share pathways with AMY1A: view

Gene Ontology (GO) - Biological Process for AMY1A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005975 carbohydrate metabolic process IEA --
GO:0007586 digestion TAS 2423416
genes like me logo Genes that share ontologies with AMY1A: view

Compounds for AMY1A Gene

(5) Drugbank Compounds for AMY1A Gene

Compound Status Synonyms Cas Number PubChem ID Type Actions PubMed IDs
46936396 Target experimental
46936574 Target experimental
50-99-7 6992084 Target experimental
Pyroglutamic Acid
98-79-3 439685 Target experimental
448009 Target experimental

(10) HMDB Compounds for AMY1A Gene

Compound Synonyms Cas Number PubMed IDs
  • Hexopyranose
  • Ca
  • Cl2
  • Caloreen
  • alpha-Malt sugar

(4) Novoseek inferred chemical compound relationships for AMY1A Gene

Compound -log(P) Hits PubMed IDs
maltoheptaose 86.2 1
amylose 80.6 3
starch 74.5 6
acarbose 73.1 2
genes like me logo Genes that share compounds with AMY1A: view

Transcripts for AMY1A Gene

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for AMY1A

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for AMY1A Gene

No ASD Table

Relevant External Links for AMY1A Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for AMY1A Gene

mRNA expression in normal human tissues for AMY1A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for AMY1A Gene

This gene is overexpressed in Pancreas (44.7).

Protein differential expression in normal tissues for AMY1A Gene

This gene is overexpressed in Saliva (54.0) and Salivary gland (11.5).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for AMY1A Gene

genes like me logo Genes that share expressions with AMY1A: view

Expression partners for AMY1A Gene

* - Elite partner

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for AMY1A Gene

Orthologs for AMY1A Gene

This gene was present in the common ancestor of animals.

Orthologs for AMY1A Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia AMY1A 35
  • 99.02 (n)
  • 99.02 (a)
(Mus musculus)
Mammalia Amy1 16
Amy1 36
  • 85 (a)
Amy2a1 36
  • 81 (a)
Amy2a2 36
  • 84 (a)
Amy2a3 36
  • 84 (a)
Amy2a4 36
  • 84 (a)
Amy2a5 36
  • 84 (a)
(Bos Taurus)
Mammalia -- 36
  • 85 (a)
AMY2B 36
  • 86 (a)
(Canis familiaris)
Mammalia -- 36
  • 88 (a)
-- 36
  • 90 (a)
-- 36
  • 88 (a)
-- 36
  • 90 (a)
-- 36
  • 90 (a)
-- 36
  • 90 (a)
(Monodelphis domestica)
Mammalia -- 36
  • 86 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 84 (a)
(Gallus gallus)
Aves AMY1A 36
  • 79 (a)
AMY2A 36
  • 83 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 80 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.8384 35
(Danio rerio)
Actinopterygii amy2a 36
  • 74 (a)
zgc:66313 36
  • 68 (a)
zgc:92137 36
  • 69 (a)
fruit fly
(Drosophila melanogaster)
Insecta Amy-d 37
  • 52 (a)
Amy-p 37
  • 52 (a)
Amyrel 37
  • 48 (a)
Amy-d 36
  • 55 (a)
Amy-p 36
  • 55 (a)
Amyrel 36
  • 49 (a)
(Caenorhabditis elegans)
Secernentea C50B6.7 37
  • 44 (a)
C50B6.7 36
  • 33 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 54 (a)
Species with no ortholog for AMY1A:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for AMY1A Gene

Gene Tree for AMY1A (if available)
Gene Tree for AMY1A (if available)

Paralogs for AMY1A Gene

Paralogs for AMY1A Gene

(4) SIMAP similar genes for AMY1A Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with AMY1A: view

Variants for AMY1A Gene

Sequence variations from dbSNP and Humsavar for AMY1A Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs465627 -- 103,655,221(+) acaca(A/G)cacta upstream-variant-2KB, intron-variant
rs61814730 -- 103,654,554(+) TCCTC(A/G)AGCTC upstream-variant-2KB, intron-variant
rs77651348 -- 103,655,691(+) GGTGA(A/G)TCTGT intron-variant, utr-variant-5-prime
rs138172355 -- 103,660,431(+) CAATC(A/G)ACGAG reference, missense
rs138704923 -- 103,660,444(+) CATGG(C/T)GCTGG reference, synonymous-codon

Structural Variations from Database of Genomic Variants (DGV) for AMY1A Gene

Variant ID Type Subtype PubMed ID
dgv75e1 CNV Complex 17122850
dgv76e1 CNV Complex 17122850
dgv77e1 CNV Complex 17122850
nsv428157 CNV Gain+Loss 18775914
nsv526367 CNV Gain 19592680
nsv830915 CNV Gain+Loss 17160897
dgv294n71 CNV Gain 21882294
dgv295n71 CNV Gain+Loss 21882294
nsv871791 CNV Loss 21882294
dgv78e1 CNV Complex 17122850
dgv299n71 CNV Gain 21882294
nsv10428 CNV Gain+Loss 18304495
esv23292 CNV Gain+Loss 19812545
nsv870628 CNV Gain 21882294
nsv517215 CNV Gain+Loss 19592680
dgv300n71 CNV Loss 21882294
dgv301n71 CNV Gain+Loss 21882294
nsv2176 CNV Loss 18451855
nsv871973 CNV Loss 21882294
nsv871974 CNV Gain+Loss 21882294
dgv302n71 CNV Loss 21882294
dgv3n14 CNV Loss 18776910
dgv303n71 CNV Gain 21882294
esv1003868 CNV Gain 20482838
esv2715585 CNV Deletion 23290073
nsv483008 CNV Complex 15286789
dgv304n71 CNV Loss 21882294
dgv305n71 CNV Loss 21882294
dgv1n31 CNV Duplication 19718026
nsv871997 CNV Gain 21882294
dgv306n71 CNV Gain 21882294
dgv307n71 CNV Gain+Loss 21882294
dgv308n71 CNV Gain+Loss 21882294
dgv58n67 CNV Gain 20364138
nsv872018 CNV Loss 21882294
dgv309n71 CNV Loss 21882294
nsv469513 CNV Gain 16826518
nsv471677 CNV Gain+Loss 15918152
dgv310n71 CNV Gain 21882294
dgv311n71 CNV Gain+Loss 21882294
nsv511121 CNV Complex 20534489
dgv312n71 CNV Loss 21882294
dgv313n71 CNV Gain 21882294
nsv7179 OTHER Inversion 18451855
dgv314n71 CNV Gain+Loss 21882294
dgv315n71 CNV Gain 21882294
dgv316n71 CNV Loss 21882294
nsv471437 CNV Duplication 19718026
dgv317n71 CNV Loss 21882294
nsv872068 CNV Loss 21882294
nsv872069 CNV Loss 21882294
nsv471346 CNV Duplication 19718026
nsv482059 CNV Gain 20164927
nsv872071 CNV Gain 21882294

Relevant External Links for AMY1A Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for AMY1A Gene

Disorders for AMY1A Gene

Relevant External Links for AMY1A

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator

No disorders were found for AMY1A Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships and Genatlas for AMY1A Gene

Publications for AMY1A Gene

  1. Diet and the evolution of human amylase gene copy number variation. (PMID: 17828263) Perry G.H. … Stone A.C. (Nat. Genet. 2007) 3 23
  2. Electrophoretic characterization of posttranslational modifications of human parotid salivary alpha-amylase. (PMID: 1710976) Bank R.A. … Pronk J.C. (Electrophoresis 1991) 3 4
  3. Primary structure of human salivary alpha-amylase gene. (PMID: 2423416) Nishide T. … Matsubara K. (Gene 1986) 3 4
  4. Identification of a human salivary amylase gene. Partial sequence of genomic DNA suggests a mode of regulation different from that of mouse, Amy1. (PMID: 2442579) Handy D.E. … Hodes M.E. (Mol. Biol. Med. 1987) 3 4
  5. Concerted evolution of human amylase genes. (PMID: 2452973) Gumucio D.L. … Meisler M.H. (Mol. Cell. Biol. 1988) 3 4

Products for AMY1A Gene

Sources for AMY1A Gene

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