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AMY1A Gene

protein-coding   GIFtS: 52
GCID: GC01P104197

Amylase, Alpha 1A (Salivary)

(Previous names: amylase, alpha 1A; salivary)
(Previous symbol: AMY1)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Amylase, Alpha 1A (Salivary)1 2     Amylase, Alpha 1A; Salivary1
AMY11 2 3     Alpha-Amylase 12
Salivary Alpha-Amylase2 3     Amylase, Salivary, Alpha-1A2
1,4-Alpha-D-Glucan Glucanohydrolase 12 3     glycogenase2
EC 3.2.1.13 8     Salivary Amylase Alpha 1A2

External Ids:    HGNC: 4741   Entrez Gene: 2762   Ensembl: ENSG000002377637   OMIM: 1047005   UniProtKB: P047453   

Export aliases for AMY1A gene to outside databases

Previous GC identifers: GC01P104923 GC01P105126 GC01P103252 GC01P103647 GC01P103553 GC01M103942 GC01P103999 GC01P102238


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for AMY1A Gene:
Amylases are secreted proteins that hydrolyze 1,4-alpha-glucoside bonds in oligosaccharides and polysaccharides,
and thus catalyze the first step in digestion of dietary starch and glycogen. The human genome has a cluster of
several amylase genes that are expressed at high levels in either salivary gland or pancreas. This gene encodes
an amylase isoenzyme produced by the salivary gland. Alternative splicing results in multiple transcript variants
encoding the same protein. (provided by RefSeq, Jul 2008)

GeneCards Summary for AMY1A Gene:
AMY1A (amylase, alpha 1A (salivary)) is a protein-coding gene. Diseases associated with AMY1A include cystadenocarcinoma, and serous cystadenocarcinoma. An important paralog of this gene is AMY2A.

Gene Wiki entry for AMY1A Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Regulatory elements:
   Regulatory transcription factor binding sites in the AMY1A gene promoter:
         Sox5   Pbx1a   FOXJ2 (long isoform)   Sox9   FOXJ2   Nkx2-5   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidAMY1A promoter sequence
   Search Chromatin IP Primers for AMY1A

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat AMY1A


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p21   Ensembl cytogenetic band:  1p21.1   HGNC cytogenetic band: 1p21

AMY1A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
AMY1A gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P104197:  view genomic region     (about GC identifiers)

Start:
104,197,912 bp from pter      End:
104,207,173 bp from pter
Size:
9,262 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: AMY1_HUMAN, P04745 (See protein sequence)
Recommended Name: Alpha-amylase 1 precursor  
Size: 511 amino acids; 57768 Da
Cofactor: Binds 1 calcium ion per subunit
Cofactor: Binds 1 chloride ion per subunit
Subunit: Monomer
Selected PDB 3D structures from and Proteopedia for AMY1A (see all 13):
1C8Q (3D)        1JXJ (3D)        1JXK (3D)        1MFU (3D)        1MFV (3D)        1NM9 (3D)    
Secondary accessions: A6NJS5 A8K8H6 Q13763 Q5T083

Explore the universe of human proteins at neXtProt for AMY1A: NX_P04745

Explore proteomics data for AMY1A at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for AMY1A (P04745) (see all 22)
     YMNHLID  GVRIYVD  YCDVISG  DNHDNQR 


    See AMY1A Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001008222.1  NP_004029.2  

    ENSEMBL proteins: 
     ENSP00000399836   ENSP00000359100   ENSP00000408386  
    Reactome Protein details: P04745

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    Selected InterPro protein domains (see all 8):
     IPR006046 Alpha_amylase
     IPR006048 A-amylase_b_C
     IPR017853 Glycoside_hydrolase_SF
     IPR006047 Glyco_hydro_13_cat_dom
     IPR013781 Glyco_hydro_catalytic_dom

    Graphical View of Domain Structure for InterPro Entry P04745

    ProtoNet protein and cluster: P04745

    3 Blocks protein domains:
    IPB006046 Alpha-amylase signature
    IPB006048 Alpha amylase
    IPB006589 Alpha amylase


    UniProtKB/Swiss-Prot: AMY1_HUMAN, P04745
    Similarity: Belongs to the glycosyl hydrolase 13 family


    AMY1A for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: AMY1_HUMAN, P04745
    Catalytic activity: Endohydrolysis of (1->4)-alpha-D-glucosidic linkages in polysaccharides containing three or
    more (1->4)-alpha-linked D-glucose units

         Genatlas biochemistry entry for AMY1A:
    amylase,alpha-1A,salivary,see AMY@

         Enzyme Number (IUBMB): EC 3.2.1.11 2

         Gene Ontology (GO): 5 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003824catalytic activity ----
    GO:0004556alpha-amylase activity ----
    GO:0005515protein binding ----
    GO:0043169cation binding ----
    GO:0046872metal ion binding ----
         
    AMY1A for ontologies           About GeneDecksing


    Phenotypes:
         1 MGI phenotypic allele for Amy1 (no phenotypes)

    AMY1A for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for AMY1A
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    GenScript: all cDNA clones in your preferred vector (see all 2): AMY1A (NM_004038)
    Browse Sino Biological Human cDNA Clones
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    AMY1_HUMAN, P04745: Secreted
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular5
    mitochondrion1
    peroxisome1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region ----

    AMY1A for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for AMY1A About   (see all 6)  
    See pathways by source

    SuperPathContained pathways About
    1Metabolism
    Metabolism0.38
    Metabolic pathways0.38
    2MPS VI - Maroteaux-Lamy syndrome
    Metabolism of carbohydrates0.45
    3Glucuronidation
    Starch and sucrose metabolism0.41
    4Salivary secretion
    Salivary secretion0.34
    5Digestion of dietary carbohydrate
    Digestion of dietary carbohydrate

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Reactome Pathway for AMY1A
        Digestion of dietary carbohydrate


    4 Kegg Pathways  (Kegg details for AMY1A):
        Starch and sucrose metabolism
    Metabolic pathways
    Salivary secretion
    Carbohydrate digestion and absorption


    AMY1A for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for AMY1A
    Interactions:

        Search GeneGlobe Interaction Network for AMY1A

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for AMY1A (P047451, 3 ENSP000003591004) via UniProtKB, MINT, STRING, and/or I2D (see all 29)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MUC7Q8TAX71, 3, ENSP000003020214EBI-738586,EBI-738582 I2D: score=2 STRING: ENSP00000302021
    AKAP1Q926673, ENSP000003377364I2D: score=2 STRING: ENSP00000337736
    AKAP8O438233, ENSP000002697014I2D: score=2 STRING: ENSP00000269701
    SOD2P041793, ENSP000003371274I2D: score=1 STRING: ENSP00000337127
    MUC5BQ9HC843, ENSP000004157934I2D: score=1 STRING: ENSP00000415793
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005975carbohydrate metabolic process ----
    GO:0007586digestion ----

    AMY1A for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for AMY1A (AMY1)

    10 HMDB Compounds for AMY1A    About this table
    CompoundSynonyms CAS #PubMed Ids
    Alpha-D-GlucoseHexopyranose (see all 11)492-62-6--
    CalciumCa (see all 2)7440-70-2--
    ChlorineCl2 (see all 13)16887-00-6--
    D-Maltosealpha-Malt sugar (see all 40)69-79-4--
    DextrinCaloreen (see all 10)9004-53-9--
    GlycogenAnimal starch (see all 5)9005-79-2--
    MaltodecaoseB-cyclodextrin (see all 19)37331-89-8--
    Maltoheptaosemaltoheptose;alpha-D-Glc-(1->4)-alpha-D-Glc-(1->4)-alpha-D-Glc-(1->4)-alpha-D-Glc-(1->4)-alpha-D-Glc-(1->4)-alpha-D-Glc-(1->4)-D-Glc;Glc(alpha1-4)Glc(alpha1-4)Glc(alpha1-4)Glc(alpha1-4)Glc(alpha1-4)Glc(alpha1-4)Glc 34620-77-4--
    Maltononaosemaltonanoose 6471-60-9--
    WaterDihydrogen oxide (see all 2)7732-18-5--

    5 DrugBank Compounds for AMY1A    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    4,6-Dideoxy-4-Amino-Alpha-D-Glucose-- --target--17139284 17016423
    5-Hydroxymethyl-Chonduritol-- --target--17139284 17016423
    Beta-D-Glucose-- 50-99-7target--17139284 17016423
    Pyroglutamic Acid-- 98-79-3target--17139284 17016423
    Tris(Hydroxyethyl)Aminomethane-- --target--17139284 17016423

    4 Novoseek inferred chemical compound relationships for AMY1A gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    maltoheptaose 86.2 1 14511369 (1)
    amylose 80.6 3 11737209 (1), 16030022 (1), 14511369 (1)
    starch 74.5 7 11737209 (1), 17828263 (1), 12906828 (1), 14660599 (1) (see all 6)
    acarbose 73.1 3 14511369 (2)



    AMY1A for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for AMY1A gene (2 alternative transcripts): 
    NM_001008221.1  NM_004038.3  

    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000430659 ENST00000370083(uc001duu.3 uc001duv.3) ENST00000422549
    ENST00000461518 ENST00000494409
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      QuantiTect SYBR Green Assays in human, mouse, rat AMY1A
      QuantiFast Probe-based Assays in human, mouse, rat AMY1A

    Selected AceView cDNA sequences (see all 283):

    CB985770 CB957283 AA367524 CB956855 BI520380 CB985352 BC069463 AI275811 
    BC070302 AA455195 CB957282 CB985304 AA367514 BC069347 CB959475 CB958389 
    AI564596 BX484519 CB987279 CB956498 CB985361 CB956028 CB985955 BV203913 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    AMY1A expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    AMY1A Expression
    About this image


    AMY1A expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 5) fully expand
     
     Brain (Nervous System)    fully expand to see all 3 entries
             Adult Dopaminergic Neurons Ventral Tegmental Area
             Cerebral Cortex
     
     Pancreas (Endocrine System)
             visceral organ/gut/foregut-midgut junction   
     
     Adipose (Muscoskeletal System)    fully expand to see all 2 entries
             Body Subcutaneous White Adipose
     
     Neural Tube (Nervous System)    fully expand to see all 2 entries
             Telencephalon
     
     Neurons
             Adult Dopaminergic Neurons Ventral Tegmental Area
    AMY1A Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    AMY1A Protein Expression
        Custom PCR Arrays for AMY1A
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    QuantiFast Probe-based Assays in human, mouse, rat AMY1A
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for AMY1A

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for AMY1A gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Amy15 amylase 1, salivary   --   3 (49.35 cM) 113555710 
    chicken
    (Gallus gallus)
    Aves AMY2A6
    AMY1A6
    Gallus gallus amylase, alpha 2A; pancreatic (AMY2A...
    Gallus gallus amylase, alpha 1A; salivary (AMY1A),...
    83(a)
    79(a)
    many ↔ many
    many ↔ many
    8(41570-46009)
    8(10001375-10007677)
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    80(a)
    1 → many
    4(85537665-85554909)
    zebrafish
    (Danio rerio)
    Actinopterygii amy2a6
    zgc:921376
    (see all 3)
    zgc:92137
    (see all 3)
    74(a)
    69(a)
    (see all 3)
    many ↔ many
    many ↔ many
    (see all 3)
    2(15433338-15447555) ENSDARG00000013856
    17(42998722-43003011) ENSDARG00000009443
    fruit fly
    (Drosophila melanogaster)
    Insecta Amy-p3 alpha-amylase 52(a)
    (best of 3)
      2 53F12   --
    worm
    (Caenorhabditis elegans)
    Secernentea C50B6.73 amylase 44(a)   V(13325025-13327571)   --


    ENSEMBL Gene Tree for AMY1A (if available)
    TreeFam Gene Tree for AMY1A (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for AMY1A gene
    AMY1C1 2  AMY1B1 2  AMY2A2  AMY2B2  
    4 SIMAP similar genes for AMY1A using alignment to 4 protein entries:     AMY1_HUMAN (see all proteins):
    AMY1B    AMY1C    AMY2B    AMY2A

    AMY1A for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for AMY1A (see all 18)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs2012881841,2
    C--104203023(+) CAGAGC/TGCTTG 4 A V mis11Minor allele frequency- T:0.00EU 1217
    rs1504051911,2
    C,F--104203041(+) GGATAA/TCCATG 4 N I mis12Minor allele frequency- T:0.00NA EU 4455
    rs1387049231,2
    C,F--104203066(+) CATGGC/TGCTGG 4 G syn12Minor allele frequency- T:0.00NA EU 4865
    rs1445314841,2
    F--104203106(+) CTAGGT/CAAAAA 2 -- spd11Minor allele frequency- C:0.00NA 3932
    rs3691582181,2
    ----104203165(+) TTGTGA/GTATTC 2 -- int10--------
    rs3736647611,2
    ----104202831(+) TGTGTA/GTATAT 2 -- int10--------
    rs3728347941,2
    ----104198042(+) TAGGCC/TACCAG 2 -- us2k10--------
    rs2002556671,2
    ----104202939(+) ACTATT/AGTGAA 2 -- int11Minor allele frequency- A:0.00EU 809
    rs1996182411,2
    ----104203534(+) TAGCCC/TGCAGG 2 -- int10--------
    rs3719108571,2
    ----104203129(+) ATTTTC/TTTAAC 2 -- int10--------

    HapMap Linkage Disequilibrium report for AMY1A (104197912 - 104207173 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for AMY1A (see all 54):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2715585CNV Deletion23290073
    nsv471346CNV Duplication19718026
    nsv471437CNV Duplication19718026
    dgv1n31CNV Duplication19718026
    nsv871973CNV Loss21882294
    nsv871791CNV Loss21882294
    dgv304n71CNV Loss21882294
    dgv305n71CNV Loss21882294
    dgv302n71CNV Loss21882294
    dgv3n14CNV Loss18776910

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

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    OMIM gene information: 104700    OMIM disorders: --

    11 diseases for AMY1A:    
    About MalaCards
    cystadenocarcinoma    serous cystadenocarcinoma    ovarian serous cystadenocarcinoma    sialadenitis
    dental caries    mucoepidermoid carcinoma    panic disorder    malaria
    pancreatitis    cerebritis    neuronitis


    AMY1A for disorders           About GeneDecksing

    Genetic Association Database (GAD): AMY1A
    Human Genome Epidemiology (HuGE) Navigator: AMY1A (1 document)

    Export disorders for AMY1A gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for AMY1A gene, integrated from 10 sources (see all 63):
    (articles sorted by number of sources associating them with AMY1A)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification of N-linked glycoproteins in human saliva by glycoprotein capture and mass spectrometry. (PubMed id 16740002)1, 2 Ramachandran P....Loo J.A. (J. Proteome Res. 2006)
    2. On the genetic polymorphism of the serum alpha-amylase in the population of the south western Bulgaria (second communication). (PubMed id 16152770)1, 4 Baltova S.D. (Folia Med (Plovdiv) 2005)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    4. Probing the role of a mobile loop in substrate binding and enzyme activity of human salivary amylase. (PubMed id 12527308)1, 2 Ramasubbu N.... Mishra P.J. (J. Mol. Biol. 2003)
    5. Structure of human salivary alpha-amylase at 1.6-A resolution: implications for its role in the oral cavity. (PubMed id 15299664)1, 2 Ramasubbu N.... Levine M.J. (Acta Crystallogr. D 1996)
    6. Electrophoretic characterization of posttranslational modifications of human parotid salivary alpha-amylase. (PubMed id 1710976)1, 2 Bank R.A.... Pronk J.C. (Electrophoresis 1991)
    7. Concerted evolution of human amylase genes. (PubMed id 2452973)1, 2 Gumucio D.L....Meisler M.H. (Mol. Cell. Biol. 1988)
    8. Identification of a human salivary amylase gene. Partial sequence of genomic DNA suggests a mode of regulation different from that of mouse, Amy1. (PubMed id 2442579)1, 2 Handy D.E.... Hodes M.E. (Mol. Biol. Med. 1987)
    9. Primary structure of human salivary alpha-amylase gene. (PubMed id 2423416)1, 2 Nishide T....Matsubara K. (Gene 1986)
    10. Corrected sequences of cDNAs for human salivary and pancreatic alpha- amylases. (PubMed id 6610603)1, 2 Nakamura Y....Matsubara K. (Gene 1984)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

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    Entrez Gene: 276 HGNC: 474 AceView: AMY1A Ensembl:ENSG00000237763 euGenes: HUgn276
    ECgene: AMY1A Kegg: 276 H-InvDB: AMY1A

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for AMY1A Pharmacogenomics, SNPs, Pathways
    Wikipedia http://en.wikipedia.org/wiki/Amylase

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for AMY1A gene:
    Search GeneIP for patents involving AMY1A

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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