Aliases for AMTN Gene
External Ids for AMTN Gene
- HGNC: 33188
- Entrez Gene: 401138
- Ensembl: ENSG00000187689
- OMIM: 610912
- UniProtKB: Q6UX39
Previous GeneCards Identifiers for AMTN Gene
- GC04P071419
- GC04P067186
Summaries for AMTN Gene
-
The mineralized portions of teeth, the dentin and enamel, are formed by mesenchyme-derived odontoblasts and epithelium-derived ameloblasts, respectively. As ameloblasts differentiate, they deposit specific proteins necessary for enamel formation, including amelogenin (AMELX; MIM 300391), enamelin (ENAM; MIM 606585), and ameloblastin (AMBN; MIM 601259), in the organic enamel matrix. Amelotin is specifically expressed in maturation-stage ameloblasts (Iwasaki et al., 2005 [PubMed 16304441]).[supplied by OMIM, Mar 2008]
GeneCards Summary for AMTN Gene
AMTN (Amelotin) is a Protein Coding gene.
UniProtKB/Swiss-Prot for AMTN Gene
-
Is a promoter of calcium phosphate mineralization, playing a critical role in the formation of the compact, mineralized, aprismatic enamel surface layer during the maturation stage of amelogenesis.
No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for AMTN Gene
Genomics for AMTN Gene
Regulatory Elements for AMTN Gene
Enhancers for AMTN Gene
| GeneHancer Identifier | Enhancer Score | Enhancer Sources | Gene-Enhancer Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites within enhancer | Gene Targets for Enhancer |
|---|---|---|---|---|---|---|---|---|
| GH04G070522 | 0.5 | ENCODE | 23.1 | +4.2 | 4199 | 0.2 | CTBP1 DPF2 ZNF24 FOXA1 | AMTN AMBN |
| GH04G070584 | 0.8 | ENCODE | 0.2 | +66.2 | 66199 | 0.1 | ZNF366 SCRT2 FOS SP3 ZEB2 ZNF843 ZNF518A ZFP69B MAFF PRDM6 | AMBN AMTN |
| GH04G070558 | 0.5 | Ensembl | 0.3 | +40.0 | 39961 | 0.2 | ZNF512 IRF1 PRDM1 | AMBN AMTN |
- Elite enhancer and/or Elite enhancer-gene association
Download GeneHancer data dump
Enhancers around AMTN on UCSC Golden Path with GeneCards custom track
Regulatory Element Products
Genomic Location for AMTN Gene
- Chromosome:
- 4
- Start:
- 70,518,540 bp from pter
- End:
- 70,532,743 bp from pter
- Size:
- 14,204 bases
- Orientation:
- Plus strand
Genomic View for AMTN Gene
Genes around AMTN on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 4q13.3 by Ensembl
- 4q13.3 by Entrez Gene
- 4q13.3 by HGNC
AMTN Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for AMTN Gene
Proteins for AMTN Gene
-
Protein details for AMTN Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q6UX39-AMTN_HUMAN
- Recommended name:
- Amelotin
- Protein Accession:
- Q6UX39
- Q0P503
- Q0P506
Protein attributes for AMTN Gene
- Size:
- 209 amino acids
- Molecular mass:
- 21588 Da
- Quaternary structure:
- No Data Available
Post-translational modifications for AMTN Gene
- O-glycosylated.
- Phosphorylated by FAM20C in vitro.
- Modification sites at PhosphoSitePlus
- Modification sites at neXtProt
Other Protein References for AMTN Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- Novus Biologicals Antibodies for AMTN
-
Abcam antibodies for AMTN
- Invitrogen Antibodies for AMTN
- GeneTex AMTN antibody for AMTN
Protein Products
-
OriGene Purified Proteins for AMTN
- Search Origene for MassSpec and Protein Over-expression Lysates for AMTN
- Origene Custom Protein Services for AMTN
- Sino Biological Recombinant Proteins for AMTN
- Sino Biological Cell Lysates for AMTN
- ProSpec Recombinant Proteins for AMTN
- Search GeneTex for Proteins for AMTN
-
Abcam proteins for AMTN
Assay Products
No data available for DME Specific Peptides for AMTN Gene
Domains & Families for AMTN Gene
Suggested Antigen Peptide Sequences for AMTN Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q6UX39- Family:
-
- Belongs to the amelotin family.
No data available for Gene Families for AMTN Gene
Function for AMTN Gene
Molecular function for AMTN Gene
- UniProtKB/Swiss-Prot Function:
- Is a promoter of calcium phosphate mineralization, playing a critical role in the formation of the compact, mineralized, aprismatic enamel surface layer during the maturation stage of amelogenesis.
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0003674 | molecular_function | ND | -- |
| GO:0005515 | protein binding | IPI | 25789606 |
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for AMTN
-
-
ViGene Biosciences lentiviral particle packaged cDNA for AMTN gene
-
ViGene Biosciences ready-to-package AAV shRNAs for AMTN gene
- Search ViGene Biosciences for AMTN
CRISPR Products
-
OriGene CRISPR knockouts for AMTN
-
Santa Cruz Biotechnology (SCBT) CRISPR for AMTN
- GenScript: Design CRISPR guide RNA sequences for AMTN
miRNA Products
- Search ViGene Biosciences for AMTN
Inhibitory RNA Products
- Origene shRNA, siRNA, and RNAi products in human, mouse, rat for AMTN
- Browse OriGene Inhibitory RNA Products For AMTN
-
ViGene Biosciences ready-to-package AAV shRNAs for AMTN gene
Clone Products
- Sino Biological Human cDNA Clone for AMTN
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for AMTN
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for AMTN
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Cell Line Products
-
Horizon Cell Lines for AMTN
-
ViGene Biosciences adenoviral particle packaged cDNA for AMTN gene
-
ViGene Biosciences lentiviral particle packaged cDNA for AMTN gene
-
ViGene Biosciences ready-to-package AAV shRNAs for AMTN gene
Flow Cytometry Products
No data available for Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for AMTN Gene
Localization for AMTN Gene
Subcellular locations from UniProtKB/Swiss-Prot for AMTN Gene
- Secreted.
| Compartment | Confidence |
|---|---|
| extracellular | 5 |
| mitochondrion | 2 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005576 | extracellular region | IEA | -- |
| GO:0005578 | proteinaceous extracellular matrix | ISS | 16304441 |
| GO:0005605 | basal lamina | ISS | 16787391 |
| GO:0005788 | endoplasmic reticulum lumen | TAS | -- |
| GO:0005911 | cell-cell junction | ISS | 16787391 |
Pathways & Interactions for AMTN Gene
No Data Available
Interacting Proteins for AMTN Gene
Selected Interacting proteins:
Q6UX39-AMTN_HUMAN
ENSP00000341013
for AMTN Gene via
IID
UniProtKB
STRING
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0007155 | cell adhesion | IEA | -- |
| GO:0031214 | biomineral tissue development | IEA | -- |
| GO:0042475 | odontogenesis of dentin-containing tooth | ISS | 16304441 |
| GO:0043687 | post-translational protein modification | TAS | -- |
| GO:0044267 | cellular protein metabolic process | TAS | -- |
No data available for Pathways by source and SIGNOR curated interactions for AMTN Gene
Transcripts for AMTN Gene
mRNA/cDNA for AMTN Gene
- (2) REFSEQ mRNAs :
- (4) Additional mRNA sequences :
- (5) Selected AceView cDNA sequences:
- (2) Ensembl transcripts including schematic representations, and UCSC links where relevant :
CRISPR Products
-
OriGene CRISPR knockouts for AMTN
-
Santa Cruz Biotechnology (SCBT) CRISPR for AMTN
- GenScript: Design CRISPR guide RNA sequences for AMTN
miRNA Products
- Search ViGene Biosciences for AMTN
Inhibitory RNA Products
- Origene shRNA, siRNA, and RNAi products in human, mouse, rat for AMTN
- Browse OriGene Inhibitory RNA Products For AMTN
-
ViGene Biosciences ready-to-package AAV shRNAs for AMTN gene
Clone Products
- Sino Biological Human cDNA Clone for AMTN
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for AMTN
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for AMTN
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Flow Cytometry Products
Expression for AMTN Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
mRNA differential expression in normal tissues according to GTEx for AMTN Gene
This gene is overexpressed in Minor Salivary Gland (x44.8).
NURSA nuclear receptor signaling pathways regulating expression of AMTN Gene:
AMTNSOURCE GeneReport for Unigene cluster for AMTN Gene:
Hs.453069Primer Products
-
OriGene qPCR primer pairs for AMTN
No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for AMTN Gene
Orthologs for AMTN Gene
This gene was present in the common ancestor of mammals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | AMTN 34 35 |
|
||
| dog (Canis familiaris) |
Mammalia | AMTN 34 35 |
|
||
| cow (Bos Taurus) |
Mammalia | AMTN 34 35 |
|
||
| mouse (Mus musculus) |
Mammalia | Amtn 34 16 35 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Amtn 34 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | AMTN 35 |
|
OneToOne |
- Species where no ortholog for AMTN was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- chicken (Gallus gallus)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- lizard (Anolis carolinensis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- platypus (Ornithorhynchus anatinus)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- tropical clawed frog (Silurana tropicalis)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
- zebrafish (Danio rerio)
Paralogs for AMTN Gene
No data available for Paralogs for AMTN Gene
Variants for AMTN Gene
| SNP ID | Clin | Chr 04 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs151041998 | A colorectal cancer sample | 70,524,899(+) | CACCT(A/G)GTACC | reference, missense | |
| rs1000205647 | -- | 70,525,986(+) | ACTTA(A/T)TCTCC | intron-variant | |
| rs1000429309 | -- | 70,520,420(+) | CCTAG(C/G)AATTA | intron-variant | |
| rs1000440233 | -- | 70,526,329(+) | TCACA(A/G)TGTTG | intron-variant | |
| rs1000488832 | -- | 70,524,692(+) | ACAAG(C/T)AGACT | intron-variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| nsv1012495 | CNV | gain | 25217958 |
Residual Variation Intolerance Score:
81.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
7.95;
83.96% of all genes are more intolerant (likely to be disease-causing)
Relevant External Links for AMTN Gene
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for AMTN Gene
Disorders for AMTN Gene
Relevant External Links for AMTN
- Atlas of Genetics and Cytogenetics in Oncology and Haematology:
- AMTN
No disorders were found for AMTN Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for AMTN Gene
Publications for AMTN Gene
- A secretory kinase complex regulates extracellular protein phosphorylation. (PMID: 25789606) Cui J. … Dixon J.E. (Elife 2015) 3 4 64
- The Enamel Protein Amelotin is a Promoter of Hydroxyapatite Mineralization. (PMID: 25407797) Abbarin N. … Ganss B. (J. Bone Miner. Res. 2014) 3 4 64
- Amelotin--a Novel Secreted, Ameloblast-specific Protein. (PMID: 16304441) Iwasaki K. … Ganss B. (J. Dent. Res. 2005) 2 3 64
- Signal peptide prediction based on analysis of experimentally verified cleavage sites. (PMID: 15340161) Zhang Z. … Henzel W.J. (Protein Sci. 2004) 3 4 64
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
Products for AMTN Gene
- Browse R&D Systems for Antibodies
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- Browse R&D Systems for biochemical assays
- Browse Primary Antibodies
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- Browse ELISAs
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- Custom Antibody ServicesOriGene Antibodies for AMTN
- Browse OriGene ELISA Kits
- Custom Assay Services
- OriGene Purified Proteins for AMTN
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- Origene Custom Protein Services for AMTN
- Origene shRNA, siRNA, and RNAi products in human, mouse, rat for AMTN
- Browse OriGene Inhibitory RNA Products For AMTN
- OriGene qPCR primer pairs for AMTN
- OriGene CRISPR knockouts for AMTN
- OriGene ORF clones in human for AMTN
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
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- GenScript: Design CRISPR guide RNA sequences for AMTN
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- Plasmid Preparation
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- Novus Biologicals Antibodies for AMTN
- Novus Biologicals proteins and lysates for AMTN
- Novus Biologicals
- Novus Biologicals Tissue Microarrays
- Abcam antibodies for AMTN
- Abcam proteins for AMTN
- Search for Assays for AMTN at Abcam
- Find your target
- Search knockout validated antibodies
- Browse monoclonal antibodies
- ProSpec Recombinant Proteins for AMTN
- ViGene Biosciences adenoviral particle packaged cDNA for AMTN gene
- ViGene Biosciences lentiviral particle packaged cDNA for AMTN gene
- ViGene Biosciences ready-to-package AAV shRNAs for AMTN gene
- Search ViGene Biosciences for AMTN
- Horizon Cell Lines for AMTN
- Cyagen custom Knockout/knockin (KOKI) mouse models for AMTN
- VectorBuilder custom plasmid, inducible vectors for AMTN
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for AMTN
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Sources for AMTN Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) RNAdb
- (29) ASD
- (30) ECgene
- (31) GeneAnnot
- (32) CGAP SAGE
- (33) SOURCE
- (34) HomoloGene
- (35) PanEnsembl
- (36) euGenes
- (37) SGD
- (38) FlyBase
- (39) WormBase
- (40) Pseudogene
- (41) DGV
- (42) dbSNP
- (43) GenAtlas
- (44) GeneTests
- (45) HGMD
- (46) GAD
- (47) LSDB
- (48) BGMUT
- (49) HuGE
- (50) eBioscience
- (51) Atlas
- (52) Cell Signaling Technology
- (53) GenBank
- (54) H-invDB
- (55) HORDE
- (56) HUGE
- (57) IMGT
- (58) Leiden
- (59) MILLIPORE
- (60) miRBase
- (61) DME
- (62) NCBI
- (63) OriGene
- (64) PubMed
- (65) R&D Systems
- (66) TGDB
- (67) Tocris
- (68) Abcam
- (69) Novus
- (70) ProSpec
- (71) Sino Biological
- (72) GenScript
- (73) Qiagen
- (74) Cloud-Clone Corp.
- (75) Enzo Life Sciences
- (76) OCA
- (77) Proteopedia
- (78) MOPED
- (79) SPIRE
- (80) neXtProt
- (81) Reactome
- (82) GeneGo (Thomson Reuters)
- (83) fRNAdb
- (84) DISEASES
- (85) SIMAP
- (86) GenomeRNAi
- (87) LifeMap
- (88) miRTarBase
- (89) MalaCards
- (90) Invitrogen
- (91) BitterDB
- (92) Vector BioLabs
- (93) ESI-BIO
- (94) RefSeq
- (95) BioSystems
- (96) MaxQB
- (97) IUPHAR
- (98) BioGPS
- (99) Illumina
- (100) COMPARTMENTS
- (101) HOMER
- (102) PaxDb
- (103) ApexBio
- (104) Addgene
- (105) antibodies-online
- (106) CYP
- (107) NONCODE
- (108) SwitchGear Genomics
- (109) TreeFam
- (110) PathCards
- (111) GeneReviews
- (112) GeneTex
- (113) Taconic Biosciences
- (114) GTEx
- (115) ProteomicsDB
- (116) SCBT
- (117) DGIdb
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- (133) NCBI Bookshelf
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- (136) ViGene Biosciences
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- (140) FANTOM5
- (141) ENCODE
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- (143) Horizon
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- (146) Cyagen
- (147) VectorBuilder
- (148) SNPedia
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- (151) CIViC
- (152) ProteoGenix
- (153) dbSUPER
- (154) TISSUES
- (155) Gene ORGANizer