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Aliases for AMTN Gene

Aliases for AMTN Gene

  • Amelotin 2 3
  • RSTI689 3
  • UNQ689 3

External Ids for AMTN Gene

Summaries for AMTN Gene

Entrez Gene Summary for AMTN Gene

  • The mineralized portions of teeth, the dentin and enamel, are formed by mesenchyme-derived odontoblasts and epithelium-derived ameloblasts, respectively. As ameloblasts differentiate, they deposit specific proteins necessary for enamel formation, including amelogenin (AMELX; MIM 300391), enamelin (ENAM; MIM 606585), and ameloblastin (AMBN; MIM 601259), in the organic enamel matrix. Amelotin is specifically expressed in maturation-stage ameloblasts (Iwasaki et al., 2005 [PubMed 16304441]).[supplied by OMIM, Mar 2008]

GeneCards Summary for AMTN Gene

AMTN (Amelotin) is a Protein Coding gene. Diseases associated with AMTN include exotropia and dental fluorosis.

UniProtKB/Swiss-Prot for AMTN Gene

  • Is a promoter of calcium phosphate mineralization, playing a critical role in the formation of the compact, mineralized, aprismatic enamel surface layer during the maturation stage of amelogenesis.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for AMTN Gene

Genomics for AMTN Gene

Genomic Location for AMTN Gene

70,518,540 bp from pter
70,532,743 bp from pter
14,204 bases
Plus strand

Genomic View for AMTN Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for AMTN Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for AMTN Gene

Regulatory Elements for AMTN Gene

Proteins for AMTN Gene

  • Protein details for AMTN Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein Accession:
    Secondary Accessions:
    • Q0P503
    • Q0P506

    Protein attributes for AMTN Gene

    209 amino acids
    Molecular mass:
    21588 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for AMTN Gene


neXtProt entry for AMTN Gene

Proteomics data for AMTN Gene at MOPED

Post-translational modifications for AMTN Gene

Other Protein References for AMTN Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for AMTN Gene

Domains for AMTN Gene

Protein Domains for AMTN Gene


Suggested Antigen Peptide Sequences for AMTN Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the amelotin family.:
    • Q6UX39
genes like me logo Genes that share domains with AMTN: view

No data available for Gene Families for AMTN Gene

Function for AMTN Gene

Molecular function for AMTN Gene

UniProtKB/Swiss-Prot Function: Is a promoter of calcium phosphate mineralization, playing a critical role in the formation of the compact, mineralized, aprismatic enamel surface layer during the maturation stage of amelogenesis.

Gene Ontology (GO) - Molecular Function for AMTN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
genes like me logo Genes that share ontologies with AMTN: view

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for AMTN Gene

Localization for AMTN Gene

Subcellular locations from UniProtKB/Swiss-Prot for AMTN Gene


Subcellular locations from

Jensen Localization Image for AMTN Gene COMPARTMENTS Subcellular localization image for AMTN gene
Compartment Confidence
extracellular 4
mitochondrion 2
nucleus 1

Gene Ontology (GO) - Cellular Components for AMTN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005578 proteinaceous extracellular matrix ISS 16304441
GO:0005605 basal lamina ISS 16787391
GO:0005911 cell-cell junction ISS 16787391
genes like me logo Genes that share ontologies with AMTN: view

Pathways for AMTN Gene

SuperPathways for AMTN Gene

No Data Available

Interacting Proteins for AMTN Gene

Gene Ontology (GO) - Biological Process for AMTN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007155 cell adhesion IEA --
GO:0031214 biomineral tissue development IEA --
GO:0042475 odontogenesis of dentin-containing tooth ISS 16304441
GO:0070169 positive regulation of biomineral tissue development IDA 25407797
genes like me logo Genes that share ontologies with AMTN: view

No data available for Pathways by source for AMTN Gene

Transcripts for AMTN Gene

mRNA/cDNA for AMTN Gene

(2) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(5) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for AMTN Gene

Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for AMTN Gene

No ASD Table

Relevant External Links for AMTN Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for AMTN Gene

mRNA expression in normal human tissues for AMTN Gene

mRNA differential expression in normal tissues according to GTEx for AMTN Gene

This gene is overexpressed in Minor Salivary Gland (44.8).

SOURCE GeneReport for Unigene cluster for AMTN Gene Hs.453069

genes like me logo Genes that share expressions with AMTN: view

No data available for Protein expression and mRNA Expression by UniProt/SwissProt for AMTN Gene

Orthologs for AMTN Gene

This gene was present in the common ancestor of mammals.

Orthologs for AMTN Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia AMTN 35
  • 98.88 (n)
  • 98.09 (a)
  • 98 (a)
(Bos Taurus)
Mammalia AMTN 35
  • 79.7 (n)
  • 69.31 (a)
  • 69 (a)
(Canis familiaris)
Mammalia AMTN 35
  • 80.65 (n)
  • 70.73 (a)
  • 68 (a)
(Mus musculus)
Mammalia Amtn 35
  • 76.28 (n)
  • 61.06 (a)
Amtn 16
Amtn 36
  • 60 (a)
(Monodelphis domestica)
Mammalia AMTN 36
  • 38 (a)
(Rattus norvegicus)
Mammalia Amtn 35
  • 75.45 (n)
  • 61.46 (a)
Species with no ortholog for AMTN:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for AMTN Gene

Gene Tree for AMTN (if available)
Gene Tree for AMTN (if available)

Paralogs for AMTN Gene

No data available for Paralogs for AMTN Gene

Variants for AMTN Gene

Sequence variations from dbSNP and Humsavar for AMTN Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type MAF
rs3223259 -- 70,530,222(+) CTTAG(-/CACA)CACAC intron-variant
rs3852096 -- 70,522,545(+) CCCTT(A/C)CCTCC intron-variant
rs3852097 -- 70,526,182(+) CTGTC(A/C)ACATT intron-variant
rs3852098 -- 70,526,436(+) CAGTG(A/C)GCATC intron-variant
rs3852099 -- 70,532,347(+) AGAAT(A/G)ATATG intron-variant

Relevant External Links for AMTN Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for AMTN Gene

Disorders for AMTN Gene

(2) MalaCards Diseases for AMTN Gene

Search for AMTN Gene in MalaCards »

(3) University of Copenhagen DISEASES for AMTN Gene

genes like me logo Genes that share disorders with AMTN: view

No data available for UniProtKB/Swiss-Prot for AMTN Gene

Publications for AMTN Gene

  1. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 3 4
  2. Signal peptide prediction based on analysis of experimentally verified cleavage sites. (PMID: 15340161) Zhang Z. … Henzel W.J. (Protein Sci. 2004) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. Amelotin--a Novel Secreted, Ameloblast-specific Protein. (PMID: 16304441) Iwasaki K. … Ganss B. (J. Dent. Res. 2005) 2 3
  5. The Enamel Protein Amelotin is a Promoter of Hydroxyapatite Mineralization. (PMID: 25407797) Abbarin N. … Ganss B. (J. Bone Miner. Res. 2014) 3 4

Products for AMTN Gene

Sources for AMTN Gene

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