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Aliases for AMTN Gene

Aliases for AMTN Gene

  • Amelotin 2 3 5
  • RSTI689 3
  • UNQ689 3

External Ids for AMTN Gene

Previous GeneCards Identifiers for AMTN Gene

  • GC04P071419
  • GC04P067186

Summaries for AMTN Gene

Entrez Gene Summary for AMTN Gene

  • The mineralized portions of teeth, the dentin and enamel, are formed by mesenchyme-derived odontoblasts and epithelium-derived ameloblasts, respectively. As ameloblasts differentiate, they deposit specific proteins necessary for enamel formation, including amelogenin (AMELX; MIM 300391), enamelin (ENAM; MIM 606585), and ameloblastin (AMBN; MIM 601259), in the organic enamel matrix. Amelotin is specifically expressed in maturation-stage ameloblasts (Iwasaki et al., 2005 [PubMed 16304441]).[supplied by OMIM, Mar 2008]

GeneCards Summary for AMTN Gene

AMTN (Amelotin) is a Protein Coding gene.

UniProtKB/Swiss-Prot for AMTN Gene

  • Is a promoter of calcium phosphate mineralization, playing a critical role in the formation of the compact, mineralized, aprismatic enamel surface layer during the maturation stage of amelogenesis.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for AMTN Gene

Genomics for AMTN Gene

Regulatory Elements for AMTN Gene

Genomic Location for AMTN Gene

70,518,540 bp from pter
70,532,743 bp from pter
14,204 bases
Plus strand

Genomic View for AMTN Gene

Genes around AMTN on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
AMTN Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for AMTN Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for AMTN Gene

Proteins for AMTN Gene

  • Protein details for AMTN Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein Accession:
    Secondary Accessions:
    • Q0P503
    • Q0P506

    Protein attributes for AMTN Gene

    209 amino acids
    Molecular mass:
    21588 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for AMTN Gene


neXtProt entry for AMTN Gene

Proteomics data for AMTN Gene at MOPED

Post-translational modifications for AMTN Gene

Other Protein References for AMTN Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for AMTN Gene

Domains & Families for AMTN Gene

Protein Domains for AMTN Gene


Suggested Antigen Peptide Sequences for AMTN Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the amelotin family.
  • Belongs to the amelotin family.
genes like me logo Genes that share domains with AMTN: view

No data available for Gene Families for AMTN Gene

Function for AMTN Gene

Molecular function for AMTN Gene

UniProtKB/Swiss-Prot Function:
Is a promoter of calcium phosphate mineralization, playing a critical role in the formation of the compact, mineralized, aprismatic enamel surface layer during the maturation stage of amelogenesis.

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for AMTN Gene

Localization for AMTN Gene

Subcellular locations from UniProtKB/Swiss-Prot for AMTN Gene


Subcellular locations from

Jensen Localization Image for AMTN Gene COMPARTMENTS Subcellular localization image for AMTN gene
Compartment Confidence
extracellular 4
mitochondrion 2

Gene Ontology (GO) - Cellular Components for AMTN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005605 basal lamina ISS 16787391
genes like me logo Genes that share ontologies with AMTN: view

Pathways & Interactions for AMTN Gene

SuperPathways for AMTN Gene

No Data Available

Interacting Proteins for AMTN Gene

Gene Ontology (GO) - Biological Process for AMTN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0031214 biomineral tissue development IEA --
GO:0070169 positive regulation of biomineral tissue development IDA 25407797
GO:0070175 positive regulation of enamel mineralization IEA --
genes like me logo Genes that share ontologies with AMTN: view

No data available for Pathways by source and SIGNOR curated interactions for AMTN Gene

Drugs & Compounds for AMTN Gene

No Compound Related Data Available

Transcripts for AMTN Gene

mRNA/cDNA for AMTN Gene

(2) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(5) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for AMTN Gene

Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for AMTN Gene

No ASD Table

Relevant External Links for AMTN Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for AMTN Gene

mRNA expression in normal human tissues for AMTN Gene

mRNA differential expression in normal tissues according to GTEx for AMTN Gene

This gene is overexpressed in Minor Salivary Gland (x44.8).

SOURCE GeneReport for Unigene cluster for AMTN Gene Hs.453069

genes like me logo Genes that share expression patterns with AMTN: view

Primer Products

In Situ Assay Products

No data available for Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for AMTN Gene

Orthologs for AMTN Gene

This gene was present in the common ancestor of mammals.

Orthologs for AMTN Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia AMTN 35
  • 79.7 (n)
  • 69.31 (a)
  • 69 (a)
(Canis familiaris)
Mammalia AMTN 35
  • 80.65 (n)
  • 70.73 (a)
  • 68 (a)
(Mus musculus)
Mammalia Amtn 35
  • 76.28 (n)
  • 61.06 (a)
Amtn 16
Amtn 36
  • 60 (a)
(Pan troglodytes)
Mammalia AMTN 35
  • 98.88 (n)
  • 98.09 (a)
  • 98 (a)
(Rattus norvegicus)
Mammalia Amtn 35
  • 75.45 (n)
  • 61.46 (a)
(Monodelphis domestica)
Mammalia AMTN 36
  • 38 (a)
Species with no ortholog for AMTN:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for AMTN Gene

Gene Tree for AMTN (if available)
Gene Tree for AMTN (if available)

Paralogs for AMTN Gene

No data available for Paralogs for AMTN Gene

Variants for AMTN Gene

Sequence variations from dbSNP and Humsavar for AMTN Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type
VAR_035791 A colorectal cancer sample
rs7660807 - 70,522,834(+) GTCAA(A/G/T)TCAGG reference, missense
rs34803339 - 70,523,877(+) TTCCT(C/T)CTTTA reference, missense
rs3852096 -- 70,522,545(+) CCCTT(A/C)CCTCC intron-variant
rs3852097 -- 70,526,182(+) CTGTC(A/C)ACATT intron-variant

Variation tolerance for AMTN Gene

Residual Variation Intolerance Score: 81.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.95; 83.96% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for AMTN Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for AMTN Gene

Disorders for AMTN Gene

Relevant External Links for AMTN

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for AMTN Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for AMTN Gene

Publications for AMTN Gene

  1. The Enamel Protein Amelotin is a Promoter of Hydroxyapatite Mineralization. (PMID: 25407797) Abbarin N. … Ganss B. (J. Bone Miner. Res. 2014) 3 4 67
  2. Amelotin--a Novel Secreted, Ameloblast-specific Protein. (PMID: 16304441) Iwasaki K. … Ganss B. (J. Dent. Res. 2005) 2 3
  3. Transcriptional regulation of amelotin gene by proinflammatory cytokines in gingival fibroblasts. (PMID: 25158173) Nakayama Y. … Ogata Y. (Connect. Tissue Res. 2014) 3
  4. Full-length transcriptome analysis of human retina-derived cell lines ARPE-19 and Y79 using the vector-capping method. (PMID: 21697133) Oshikawa M. … Kato S. (Invest. Ophthalmol. Vis. Sci. 2011) 3
  5. Cloning of rat amelotin and localization of the protein to the basal lamina of maturation stage ameloblasts and junctional epithelium. (PMID: 16787391) Moffatt P. … Nanci A. (Biochem. J. 2006) 3

Products for AMTN Gene

Sources for AMTN Gene

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