Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

AMPD2 Gene

protein-coding   GIFtS: 66
GCID: GC01P110162

adenosine monophosphate deaminase 2

(Previous name: adenosine monophosphate deaminase 2 (isoform L) )
 Explore 5 diseases affiliated with
AMPD2 via our new
 Human Malady Compendium 
Biological research products
for AMPD2
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
Adenosine Monophosphate Deaminase 21 2
Adenosine Monophosphate Deaminase 2 (Isoform L)1 2
EC 3.5.4.63 8
AMPD2
AMP Deaminase 22
AMP Deaminase Isoform L3

External Ids:    HGNC: 4691   Entrez Gene: 2712   Ensembl: ENSG000001163377   OMIM: 1027715   UniProtKB: Q014333   

Export aliases for AMPD2 gene to outside databases

Previous GC identifers: GC01P110641 GC01P109091 GC01P109264 GC01P109461 GC01P109874 GC01P109963 GC01P108054


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for AMPD2:
The protein encoded by this gene is important in purine metabolism by converting AMP to IMP. The encoded protein, which
acts as a homotetramer, is one of three AMP deaminases found in mammals. Several transcript variants encoding
different isoforms have been found for this gene. (provided by RefSeq, Apr 2012)

UniProtKB/Swiss-Prot: AMPD2_HUMAN, Q01433
Function: AMP deaminase plays a critical role in energy metabolism

Gene Wiki entry for AMPD2


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NC_018912.1  NT_032977.9  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the AMPD2 gene promoter:
         SRF   CP2   SRF (504 AA)   C/EBPalpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): AMPD2 promoter sequence
   Search SABiosciences Chromatin IP Primers for AMPD2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat AMPD2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p13.3   Ensembl cytogenetic band:  1p13.3   HGNC cytogenetic band: 1p13.3

AMPD2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
AMPD2 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P110162:  view genomic region     (about GC identifiers)

Start:
110,158,726 bp from pter      End:
110,174,677 bp from pter
Size:
15,952 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: AMPD2_HUMAN, Q01433 (See protein sequence)
Recommended Name: AMP deaminase 2  
Size: 879 amino acids; 100688 Da
Cofactor: Binds 1 zinc ion per subunit (By similarity)
Subunit: Homotetramer
Secondary accessions: B4DK50 B4DZI5 E9PNG0 Q14856 Q14857 Q16686 Q16687 Q16688 Q16729 Q5T693 Q5T695
Q96IA1 Q9UDX8 Q9UDX9 Q9UMU4
Alternative splicing: 5 isoforms:  Q01433-1   Q01433-2   Q01433-3   Q01433-4   Q01433-5   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for AMPD2: NX_Q01433

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q01433

  • 4/12 DME Specific Peptides for AMPD2 (Q01433) (see all 12)
     NVRWLVQ  WKLSSCD  PHRDFYN  SPNVRWL 

    AMPD2 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (5 alternative transcripts): 
    NP_001244289.1  NP_001244290.1  NP_004028.3  NP_631895.1  NP_981949.1  

    ENSEMBL proteins: 
     ENSP00000433739   ENSP00000345498   ENSP00000436303   ENSP00000432344   ENSP00000436541  
     ENSP00000431975   ENSP00000256578   ENSP00000351573   ENSP00000358855   ENSP00000434891  
     ENSP00000431904   ENSP00000437164   ENSP00000377292   ENSP00000437025  
    Reactome Protein details: Q01433
    Human Recombinant Protein Products: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein: AMPD2
    OriGene Protein Over-expression Lysate: AMPD2
    OriGene Custom Protein Services for AMPD2 
    GenScript Custom Purified and Recombinant Proteins Services for AMPD2
    Novus Biologicals AMPD2 Proteins
    Novus Biologicals AMPD2 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for AMPD2

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005575cellular_component ND--
    GO:0005829cytosol TAS--


    AMPD2 for ontologies           About GeneDecksing



    AMPD2 Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for AMPD2 
    GenScript Custom Superior Antibodies Services for AMPD2
    Novus Biologicals AMPD2 Antibodies
    Abcam antibodies for AMPD2 
    Uscn Antibodies for AMPD2
    ThermoFisher Antibody for AMPD2

    Assay Products for AMPD2: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Immunoassay Development
    Browse OriGene Fluorogenic Cell Assay Kits
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for AMPD2
    Browse Enzo Life Sciences for kits & assays
    Uscn ELISAs and CLIAs for AMPD2


    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    AMPD2 for domains           About GeneDecksing

    3 InterPro domains/families:
     IPR001365 A/AMP_deaminase_dom
     IPR006329 AMP_deaminase
     IPR006650 A/AMP_deam_AS

    Graphical View of Domain Structure for InterPro Entry Q01433

    ProtoNet protein and cluster: Q01433

    1 Blocks protein family: IPB006650 Adenosine/AMP deaminase active site

    UniProtKB/Swiss-Prot: AMPD2_HUMAN, Q01433
    Similarity: Belongs to the adenosine and AMP deaminases family


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    Function Summary:

         UniProtKB/Swiss-Prot: AMPD2_HUMAN, Q01433
    Function: AMP deaminase plays a critical role in energy metabolism
    Catalytic activity: AMP + H(2)O = IMP + NH(3)

         Genatlas biochemistry entry for AMPD2:
    adenosine monophosphate deaminase 2 (88kDa) (isoform L,liver),adenine nucleotide catabolic pathway,purine nucleotide
    cycle

    Enzyme Number (IUBMB): EC 3.5.4.61 2

    miRNA
    Products:
        
    OriGene 3'-UTR Clone (see all 3): AMPD2
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat AMPD2
    8/16 QIAGEN miScript miRNA Assays for microRNAs that regulate AMPD2 (see all 16):
    hsa-miR-3678-3p hsa-miR-34c-5p hsa-miR-3194-5p hsa-miR-449b hsa-miR-513a-5p hsa-miR-27a hsa-miR-200a hsa-miR-3120-3p
    SwitchGear 3'UTR luciferase reporter plasmidAMPD2 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for AMPD2 (see all 7)
    OriGene shRNA RFP: AMPD2
    OriGene siRNA: AMPD2
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat AMPD2

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for AMPD2

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for AMPD2 (see all 5)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for AMPD2 (see all 3)
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector (see all 3): AMPD2 (NM_139156)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for AMPD2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat AMPD2 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for AMPD2
    Search LifeMap BioReagents cell lines for AMPD2

    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for AMPD2

    Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003876AMP deaminase activity NAS8764830
    GO:0046872metal ion binding IEA--


    AMPD2 for ontologies           About GeneDecksing


    2 GenomeRNAi human phenotypes for AMPD2:
     Increased G1 DNA content  Synthetic lethal with paclitax 


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Purine metabolism
    Purine metabolism1.00
    Purine salvage0.39
    Metabolism of nucleotides0.42
    2Metabolism
    Metabolism1.00
    Metabolic pathways0.38
    3ATP/ITP metabolism
    ATP/ITP metabolism1.00
    ATP/ITP metabolism0.98
    4Purine metabolism
    Purine metabolism1.00

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    1 EMD Millipore Pathway for AMPD2
        ATP/ITP metabolism


    1 GeneGo (Thomson Reuters) Pathway for AMPD2
        ATP/ITP metabolism

    4        Reactome Pathways for AMPD2
        Metabolism of nucleotides
    Metabolism
    Purine salvage
    Purine metabolism


    2         Kegg Pathways  (Kegg details for AMPD2):
        Purine metabolism
    Metabolic pathways

    UniProtKB/Swiss-Prot: AMPD2_HUMAN, Q01433
    Pathway: Purine metabolism; IMP biosynthesis via salvage pathway; IMP from AMP: step 1/1


    AMPD2 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for AMPD2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/77 Interacting proteins for AMPD2 (Q014333 ENSP000002565784) via UniProtKB, MINT, STRING, and/or I2D (see all 77)

    InteractantInteraction Details
    GeneCardExternal ID(s)
    ALADP137163, ENSP000003862844I2D: score=1 STRING: ENSP00000386284
    UBCP0CG483, ENSP000003448184I2D: score=1 STRING: ENSP00000344818
    MARCH6O603373I2D: score=3 
    NEDD4LQ96PU53I2D: score=3 
    PIN1Q135263I2D: score=3 
    About this table

    Gene Ontology (GO): 5/7 biological process terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006144purine nucleobase metabolic process TAS--
    GO:0006163purine nucleotide metabolic process NAS--
    GO:0006188IMP biosynthetic process ----
    GO:0032264IMP salvage IEA--
    GO:0043101purine-containing compound salvage TAS--


    AMPD2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    AMPD2 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for AMPD2

    5 HMDB Compounds for AMPD2    About this table
    CompoundSynonyms CAS #PubMed Ids
    Adenosine monophosphate5'-AMP (see all 28)61-19-8--
    AmmoniaNH3 (see all 31)7664-41-7--
    Inosinic acid5'-IMP (see all 9)131-99-7--
    PropranololDociton (see all 8)525-66-6--
    WaterDihydrogen oxide (see all 2)7732-18-5--
    1 Novoseek chemical compound relationship for AMPD2 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    adenylate 30.7 1 7698751 (1)

    Search CenterWatch for drugs/clinical trials and news about AMPD2 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for AMPD2 gene (5 alternative transcripts): 
    NM_001257360.1  NM_001257361.1  NM_004037.7  NM_139156.3  NM_203404.1  

    Unigene Cluster for AMPD2:

    Adenosine monophosphate deaminase 2
    Hs.82927  [show with all ESTs]
    Unigene Representative Sequence: NM_001257360
    18/26 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 26):
    ENST00000531734 ENST00000526301(uc009wfg.1) ENST00000342115(uc001dyb.1 uc009wfh.1 uc001dye.1)
    ENST00000469039 ENST00000474459 ENST00000528667 ENST00000531203 ENST00000256578(uc001dyc.1 uc010ovr.1)
    ENST00000358729 ENST00000369840 ENST00000486282 ENST00000528270 ENST00000527846
    ENST00000528454(uc010ovs.1) ENST00000459643 ENST00000393688(uc001dyd.1)
    ENST00000534144 ENST00000525415

    miRNA
    Products:
         
    OriGene 3'-UTR Clone (see all 3): AMPD2
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat AMPD2
    8/16 QIAGEN miScript miRNA Assays for microRNAs that regulate AMPD2 (see all 16):
    hsa-miR-3678-3p hsa-miR-34c-5p hsa-miR-3194-5p hsa-miR-449b hsa-miR-513a-5p hsa-miR-27a hsa-miR-200a hsa-miR-3120-3p
    SwitchGear 3'UTR luciferase reporter plasmidAMPD2 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for AMPD2 (see all 7)
    OriGene shRNA RFP: AMPD2
    OriGene siRNA: AMPD2
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat AMPD2
    Clone
    Products:
         
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for AMPD2 (see all 5)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for AMPD2 (see all 3)
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector (see all 3): AMPD2 (NM_139156)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for AMPD2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat AMPD2 
    Primer
    Products:
        
    OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for AMPD2
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat AMPD2
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat AMPD2
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat AMPD2

    Additional cDNA sequence: 

    AK025706.1 AK296394.1 AK302939.1 AK308907.1 AK314494.1 BC007711.2 BC030217.1 BC075844.1 
    S47833.1 U16267.1 U16268.1 U16270.1 

    24 DOTS entries:

    DT.75148818  DT.447282  DT.101969791  DT.100810284  DT.121383307  DT.100839497  DT.95331169  DT.121383296 
    DT.91775668  DT.99942917  DT.95351065  DT.100700047  DT.95331206  DT.100810281  DT.121383338  DT.91746871 
    DT.97848392  DT.100810283  DT.121383286  DT.121383299  DT.121383301  DT.121383349  DT.91775658  DT.70104272 

    24/320 AceView cDNA sequences (see all 320):

    AU125519 BX505961 BX279634 BQ689810 NM_004037 BQ897861 BQ682121 BM791872 
    AI272266 BQ053499 CA488521 BU189675 BX382066 BC075844 U16268 BG194460 
    CB155218 S47833 BM724781 BM834043 AI276760 AI148486 BM714944 AU124824 

    GeneLoc Exon Structure

    5/18 Alternative Splicing Database (ASD) splice patterns (SP) for AMPD2 (see all 18)    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b ^ 8a · 8b · 8c ^ 9 ^ 10a · 10b · 10c ^ 11a · 11b · 11c · 11d · 11e · 11f · 11g ^
    SP1:              -     -     -     -     -     -                 -           -                                         -     -                                 
    SP2:                                                                          -                                         -     -                                 
    SP3:                                                              -           -                                         -     -                                 
    SP4:              -     -     -     -     -     -     -     -     -           -                                         -     -                                 
    SP5:                                -     -     -                 -           -                                                                                 

    ExUns: 12 ^ 13a · 13b ^ 14a · 14b ^ 15a · 15b ^ 16a · 16b ^ 17a · 17b ^ 18a · 18b · 18c ^ 19 ^ 20 ^ 21a · 21b ^ 22a · 22b · 22c
    SP1:                                            -           -                 -     -                 -                           
    SP2:                                            -           -                 -     -                 -                           
    SP3:                                                                                                                              
    SP4:                                                                                                                              
    SP5:                                                                                                                              


    ECgene alternative splicing isoforms for AMPD2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    AMPD2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: AGAAATAAAG

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)

    About this image
    See AMPD2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for AMPD2

    SOURCE GeneReport for Unigene cluster: Hs.82927

    UniProtKB/Swiss-Prot: AMPD2_HUMAN, Q01433
    Tissue specificity: Three isoforms are present in mammals: AMP deaminase 1 is the predominant form in skeletal muscle;
    AMP deaminase 2 predominates in smooth muscle, non-muscle tissue, embryonic muscle and undifferentiated myoblasts; AMP
    deaminase 3 is found in erythrocytes

        SABiosciences Custom PCR Arrays for AMPD2
    Primer
    Products:
    OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for AMPD2
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat AMPD2
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat AMPD2
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat AMPD2
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for AMPD2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for AMPD2 gene from 8/35 species (see all 35)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    chicken
    (Gallus gallus)
    Aves LOC1008583161 AMP deaminase 2-like 85.68(n)
    92.74(a)
      100858316  XM_003643407.1  XP_003643455.1 
    lizard
    (Anolis carolinensis)
    Reptilia AMPD26
    --
    86(a)
    1 ↔ 1
    4(105860722-105888885)
    zebrafish
    (Danio rerio)
    Actinopterygii LOC1003307721 AMP deaminase 2-like 74.76(n)
    78.44(a)
      100330772  XM_002666129.2  XP_002666175.2 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG326261 CG32626 64.08(n)
    62.7(a)
      32352  NM_167384.2  NP_727739.3 
    worm
    (Caenorhabditis elegans)
    Secernentea C34F11.3b3
    C34F11.31
    Protein C34F11.31 57(a)
    (best of 2)3
    56.92(n)1
    57.16(a)1
      II(5202470-5209649)3
    1738911  NM_062573.41  NP_494974.21 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes AMD1(YML035C)4
    AMD11
    AMP deaminase, tetrameric enzyme that catalyzes the more4
    Amd1p1
    51.06(n)1
    53.51(a)1
      13(208860-206428)4
    8549731, 4  NP_013677.11, 4 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons FAC11 AMP deaminase 51.84(n)
    49.25(a)
      818408  NM_179963.2  NP_850294.1 
    rice
    (Oryza sativa)
    Liliopsida Os.87792 Oryza sativa (japonica cultivar-group) cDNA cloneJ more 72.76(n)    AK102007.1 


    ENSEMBL Gene Tree for AMPD2 (if available)
    TreeFam Gene Tree for AMPD2 (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for AMPD2 gene
    AMPD12  AMPD32  
    2 SIMAP similar genes for AMPD2 using alignment to 7 protein entries:     AMPD2_HUMAN (see all proteins):
    AMPD1    AMPD3

    AMPD2 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/242 NCBI SNPs in AMPD2 are shown (see all 242    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1383534331,2
    --110160566(+) TAAGCG/TCCCCA 2 -- us2k10--------
    rs1815503621,2
    --110160632(+) ACCCCA/GGGAAG 2 -- us2k10--------
    rs1871050721,2
    --110160658(+) CTGTGG/TAGGCA 2 -- us2k10--------
    rs1496382401,2
    --110160680(+) TTACAG/TATTTT 2 -- us2k10--------
    rs1433730951,2
    --110160757(+) AATATA/GAAGAA 2 -- us2k10--------
    rs749156721,2
    --110160852(+) ATAAGC/TAGGAC 2 -- us2k10--------
    rs1918885571,2
    --110160910(+) TTGTAA/GACATT 2 -- us2k10--------
    rs1148006091,2
    F,--110161002(+) TTGTTC/TGACCT 2 -- us2k11Minor allele frequency- T:0.04WA 118
    rs1839390121,2
    --110161085(+) CAGCTC/GTTTTT 2 -- us2k10--------
    rs1468637571,2
    --110161233(+) TGTAC-/GTGTGTG 3 -- us2k10--------

    HapMap Linkage Disequilibrium report for AMPD2 (110158726 - 110174677 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 2 variations for AMPD2
         2 CNVs: 34677 34676

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing AMPD2
    DNA2.0 Custom Variant and Variant Library Synthesis for AMPD2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    AMPD2 for disorders           About GeneDecksing

    OMIM gene information: 102771    OMIM disorders: --

    5 diseases for AMPD2:    About MalaCards
    major depressive disorder    hepatocellular carcinoma    atherosclerosis    carcinoma
    malaria

    1 disease from the University of Copenhagen DISEASES database for AMPD2:
    Liver neoplasm
    Human Genome Epidemiology (HuGE) Navigator: AMPD2 (1 document)

    Export disorders for AMPD2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for AMPD2 gene, integrated from 9 sources (see all 35):
    (articles sorted by number of sources associating them with AMPD2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Characterization of human AMP deaminase 2 (AMPD2) gene expression reveals alternative transcripts encoding variable N-terminal extensions of isoform L. (PubMed id 8526848)1, 2, 9 Van den Bergh F. and Sabina R.L. (1995)
    2. Molecular cloning of AMP deaminase isoform L. Sequence and bacterial expression of human AMPD2 cDNA. (PubMed id 1429593)1, 2, 9 Bausch-Jurken M.T.... Sabina R.L. (1992)
    3. Cloning, sequence and characterization of the human AMPD2 gene: evidence for transcriptional regulation by two closely spaced promoters. (PubMed id 8764830)1, 2, 9 Mahnke-Zizelman D.K.... Sabina R.L. (1996)
    4. Cloning of human AMP deaminase isoform E cDNAs. Evidence for a third AMPD gene exhibiting alternatively spliced 5'-exons. (PubMed id 1400401)1, 3, 9 Mahnke-Zizelman D.K. and Sabina R.L. (1992)
    5. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (2006)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    7. Expression patterns of AMP-deaminase isozymes in human hepatocellular carcinoma (HCC). (PubMed id 18493842)1, 9 Szydl/owska M. and Roszkowska A. (2008)
    8. A high-throughput approach for measuring temporal chan ges in the interactome. (PubMed id 22863883)1 Kristensen A.R....Foster L.J. (2012)
    9. A catalogue of putative HIV-1 protease host cell subst rates. (PubMed id 22944692)1 Impens F....Gevaert K. (2012)
    10. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 271 HGNC: 469 AceView: AMPD2 Ensembl:ENSG00000116337 euGenes: HUgn271
    ECgene: AMPD2 Kegg: 271 H-InvDB: AMPD2

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for AMPD2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for AMPD2 gene:
    Search GeneIP for patents involving AMPD2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
    In Situ Hybridization Assays from
    Advanced Cell Diagnostics
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Phosphatase Activity Assays/Reagents   Browse Recombinant/Natural Proteins  
     Browse OriGene Antibodies   OriGene shRNA RFP for AMPD2  
     OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for AMPD2   OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for AMPD2  
     OriGene Protein Over-expression Lysate for AMPD2   Browse OriGene Fluorogenic Cell Assay Kits  
     OriGene siRNA for AMPD2   OriGene 3'-UTR Clone for AMPD2  
     OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for AMPD2   OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for AMPD2  
     Browse OriGene GFP tagged cDNA clones in CMV expression vector   Browse OriGene MicroRNA Expression Plasmids  
     Browse OriGene basic RS shRNAs   Browse OriGene validated miRNA SYBR primer pairs  
     OriGene Purified Protein for AMPD2   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for AMPD2   OriGene Custom Protein Services for AMPD2  
     OriGene Custom Immunoassay Development  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat AMPD2
     QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing AMPD2
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat AMPD2
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat AMPD2
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat AMPD2
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat AMPD2
     GenScript Custom Purified and Recombinant Proteins Services for AMPD2 GenScript cDNA clones with any tag delivered in your preferred vector for AMPD2
     GenScript Custom Assay Services for AMPD2 GenScript Custom Superior Antibodies Services for AMPD2
     GenScript Custom overexpressing Cell Line Services for AMPD2 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in AMPD2 promoter
     Search Chromatin IP Primers for AMPD2
     RT2 qPCR Primer Assay in human, mouse, rat AMPD2
     Search GNC Networks for AMPD2
     SABiosciences Custom PCR Arrays for AMPD2
     Search Tocris compounds for AMPD2
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological cDNA Clones
     Antibodies/Proteins Production Services
     Rabbit Monoclonal Antibody Platform
     Bulk Purchasing
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     AMPD2 antibodies
     AMPD2 proteins
     AMPD2 lysates
     Antibodies for AMPD2
     See all of Abcam's Antibodies, Kits and Proteins for AMPD2
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     AMPD2 Proteins, Antibodies, CLIAs, and ELISAs
     Search LifeMap BioReagents cell lines for AMPD2
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for AMPD2
     SwitchGear 3'UTR luciferase reporter plasmids for AMPD2
     SwitchGear Promoter luciferase reporter plasmids for AMPD2
     ThermoFisher Antibody for AMPD2
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat AMPD2
           
    GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 27 Apr 2013

    View Random Gene

    Category
    VWF
    (GIFTS: 73)
    von Willebrand factor
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      AMPD2 gene at Home site.
    hostname: 356980-web2.xennexinc.com index build: 100 solr: 1.4