Aliases for AMOTL2 Gene
Aliases for AMOTL2 Gene
External Ids for AMOTL2 Gene
- HGNC: 17812
- Entrez Gene: 51421
- Ensembl: ENSG00000114019
- OMIM: 614658
- UniProtKB: Q9Y2J4
Previous GeneCards Identifiers for AMOTL2 Gene
- GC03M131013
- GC03M134860
- GC03M135356
- GC03M135395
- GC03M135556
- GC03M134074
- GC03M131452
Summaries for AMOTL2 Gene
-
Angiomotin is a protein that binds angiostatin, a circulating inhibitor of the formation of new blood vessels (angiogenesis). Angiomotin mediates angiostatin inhibition of endothelial cell migration and tube formation in vitro. The protein encoded by this gene is related to angiomotin and is a member of the motin protein family. Alternative splicing results in multiple transcript variants of this gene. [provided by RefSeq, Jul 2013]
GeneCards Summary for AMOTL2 Gene
AMOTL2 (Angiomotin Like 2) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Tight junction. GO annotations related to this gene include identical protein binding. An important paralog of this gene is AMOTL1.
UniProtKB/Swiss-Prot for AMOTL2 Gene
-
Regulates the translocation of phosphorylated SRC to peripheral cell-matrix adhesion sites. Required for proper architecture of actin filaments. Inhibits the Wnt/beta-catenin signaling pathway, probably by recruiting CTNNB1 to recycling endosomes and hence preventing its translocation to the nucleus. Participates in angiogenesis. May play a role in the polarity, proliferation and migration of endothelial cells. Selectively promotes FGF-induced MAPK activation through SRC.
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for AMOTL2 Gene
Genomics for AMOTL2 Gene
Regulatory Elements for AMOTL2 Gene
Enhancers for AMOTL2 Gene
| GeneHancer Identifier | Enhancer Score | Enhancer Sources | Gene-Enhancer Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites within enhancer | Gene Targets for Enhancer |
|---|---|---|---|---|---|---|---|---|
| GH03G134322 | 1.9 | FANTOM5 Ensembl ENCODE dbSUPER | 17.8 | +45.2 | 45229 | 15.1 | PKNOX1 FOXA2 ARNT ARID4B SIN3A ZBTB7B FOS DEK SP5 REST | AMOTL2 ENSG00000260633 TFP1 ANAPC13 LOC105374118 |
| GH03G134340 | 1 | Ensembl dbSUPER | 11.9 | +34.5 | 34479 | 0.4 | ELF3 SOX13 SAP130 ARID4B ZSCAN9 ZNF644 RARA ZFHX2 RERE NR2F6 | AMOTL2 ANAPC13 ENSG00000260633 LOC105374118 |
| GH03G134299 | 0.6 | Ensembl | 11.2 | +75.9 | 75878 | 0.4 | CTCF PKNOX1 PBX2 SMC3 PRDM1 RAD21 NR2F2 | AMOTL2 CEP63 ANAPC13 RYK ENSG00000260633 LINC02004 |
| GH03G134347 | 1.9 | FANTOM5 Ensembl ENCODE dbSUPER | 3.5 | +13.6 | 13638 | 29.3 | HDGF PKNOX1 FOXA2 ARID4B SIN3A DMAP1 FEZF1 ZNF2 ZBTB7B YY1 | ENSG00000260633 TFP1 RYK RAB6B AMOTL2 RPL39P5 MIR6827 |
| GH03G134397 | 0.4 | dbSUPER | 12.1 | -20.3 | -20329 | 3.3 | NFE2 NR2F2 | AMOTL2 HMGN1P9 ANAPC13 CEP63 ENSG00000260633 HMGB3P13 |
- Elite enhancer and/or Elite enhancer-gene association
Download GeneHancer data dump
Enhancers around AMOTL2 on UCSC Golden Path with GeneCards custom track
Regulatory Element Products
Genomic Location for AMOTL2 Gene
- Chromosome:
- 3
- Start:
- 134,355,345 bp from pter
- End:
- 134,375,479 bp from pter
- Size:
- 20,135 bases
- Orientation:
- Minus strand
Genomic View for AMOTL2 Gene
Genes around AMOTL2 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 3q22.2 by Ensembl
- 3q22.2 by Entrez Gene
- 3q22.2 by HGNC
AMOTL2 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for AMOTL2 Gene
Proteins for AMOTL2 Gene
-
Protein details for AMOTL2 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q9Y2J4-AMOL2_HUMAN
- Recommended name:
- Angiomotin-like protein 2
- Protein Accession:
- Q9Y2J4
- A8K6F1
- B7Z5Q1
- E9PHW3
- Q53EP1
- Q96F99
- Q9UKB4
Protein attributes for AMOTL2 Gene
- Size:
- 779 amino acids
- Molecular mass:
- 85764 Da
- Quaternary structure:
-
- Interacts with SRC.
- SequenceCaution:
-
- Sequence=AAH11454.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAA76833.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=BAD97318.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};
Protein Expression for AMOTL2 Gene
Post-translational modifications for AMOTL2 Gene
- Phosphorylation at Tyr-107 is necessary for efficient binding to SRC and synergistically functioning with SRC to activate the downstream MAPK pathway.
- Modification sites at PhosphoSitePlus
- Modification sites at neXtProt
Other Protein References for AMOTL2 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
-
Custom Antibody ServicesOriGene Antibodies for AMOTL2
- Novus Biologicals Antibodies for AMOTL2
-
Abcam antibodies for AMOTL2
- Invitrogen Antibodies for AMOTL2
- antibodies-online Antibodies for AMOTL2: See all 28
- GeneTex AMOTL2 antibody for AMOTL2
-
Santa Cruz Biotechnology (SCBT) Antibodies for AMOTL2
Protein Products
-
OriGene Purified Proteins for AMOTL2
- Search Origene for MassSpec and Protein Over-expression Lysates for AMOTL2
- Origene Custom Protein Services for AMOTL2
- antibodies-online Proteins for AMOTL2: See all 4
- Search antibodies-online for peptides
- Search GeneTex for Proteins for AMOTL2
-
Abcam proteins for AMOTL2
Assay Products
- antibodies-online Kits for AMOTL2: See all 6
No data available for DME Specific Peptides for AMOTL2 Gene
Domains & Families for AMOTL2 Gene
Protein Domains for AMOTL2 Gene
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for AMOTL2 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q9Y2J4- Family:
-
- Belongs to the angiomotin family.
No data available for Gene Families for AMOTL2 Gene
Function for AMOTL2 Gene
Molecular function for AMOTL2 Gene
- UniProtKB/Swiss-Prot Function:
- Regulates the translocation of phosphorylated SRC to peripheral cell-matrix adhesion sites. Required for proper architecture of actin filaments. Inhibits the Wnt/beta-catenin signaling pathway, probably by recruiting CTNNB1 to recycling endosomes and hence preventing its translocation to the nucleus. Participates in angiogenesis. May play a role in the polarity, proliferation and migration of endothelial cells. Selectively promotes FGF-induced MAPK activation through SRC.
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005515 | protein binding | IPI | 16189514 |
| GO:0042802 | identical protein binding | IEA | -- |
Phenotypes for AMOTL2 Gene
- GenomeRNAi human phenotypes for AMOTL2:
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for AMOTL2
-
-
ViGene Biosciences lentiviral particle packaged cDNA for AMOTL2 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for AMOTL2 gene
- Search ViGene Biosciences for AMOTL2
CRISPR Products
-
OriGene CRISPR knockouts for AMOTL2
-
Santa Cruz Biotechnology (SCBT) CRISPR for AMOTL2
- GenScript: Design CRISPR guide RNA sequences for AMOTL2
miRNA for AMOTL2 Gene
- miRTarBase miRNAs that target AMOTL2
-
- hsa-mir-27a-3p (MIRT028729)
- hsa-mir-6716-5p (MIRT481963)
- hsa-mir-376b-3p (MIRT481964)
- hsa-mir-376a-3p (MIRT481965)
- hsa-mir-6783-3p (MIRT481966)
- hsa-mir-1343-3p (MIRT481967)
- hsa-mir-877-5p (MIRT481968)
- hsa-mir-4437 (MIRT481969)
- hsa-mir-6124 (MIRT481970)
- hsa-mir-4646-5p (MIRT481971)
- hsa-mir-204-3p (MIRT481972)
- hsa-mir-6852-5p (MIRT481973)
- hsa-mir-6742-3p (MIRT481974)
- hsa-mir-939-3p (MIRT481975)
- hsa-mir-135a-3p (MIRT481976)
- hsa-mir-3158-3p (MIRT481977)
- hsa-mir-4446-3p (MIRT481978)
- hsa-mir-5088-5p (MIRT481979)
- hsa-mir-6859-5p (MIRT481980)
- hsa-mir-3916 (MIRT481981)
- hsa-mir-3714 (MIRT481982)
- hsa-mir-3125 (MIRT481983)
- hsa-mir-4662a-3p (MIRT481984)
- hsa-mir-548an (MIRT481985)
- hsa-mir-891a-3p (MIRT481986)
- hsa-mir-3175 (MIRT481987)
- hsa-mir-8085 (MIRT481988)
- hsa-mir-6731-5p (MIRT481989)
- hsa-mir-24-3p (MIRT481990)
- hsa-mir-4284 (MIRT481991)
- hsa-mir-4644 (MIRT481992)
- hsa-mir-4306 (MIRT481993)
- hsa-mir-185-5p (MIRT481994)
- hsa-mir-2467-3p (MIRT481995)
- hsa-mir-6847-5p (MIRT481996)
- hsa-mir-7843-5p (MIRT481997)
- hsa-mir-6879-5p (MIRT481998)
- hsa-mir-6735-5p (MIRT481999)
- hsa-mir-4632-5p (MIRT482000)
- hsa-mir-4436b-3p (MIRT482001)
- hsa-mir-4779 (MIRT482002)
- hsa-mir-3123 (MIRT482003)
- hsa-mir-4446-5p (MIRT660697)
- hsa-mir-5006-3p (MIRT660698)
- hsa-mir-4755-5p (MIRT660699)
- hsa-mir-211-5p (MIRT660700)
- hsa-mir-204-5p (MIRT660701)
- hsa-mir-623 (MIRT660702)
- hsa-mir-6862-3p (MIRT660703)
- hsa-mir-6784-3p (MIRT660704)
- hsa-mir-5088-3p (MIRT660705)
- hsa-mir-3620-3p (MIRT660706)
- hsa-mir-6865-3p (MIRT660707)
- hsa-mir-4668-3p (MIRT660708)
- hsa-mir-8063 (MIRT660709)
- hsa-mir-580-3p (MIRT711831)
- hsa-mir-4775 (MIRT711832)
- hsa-mir-3119 (MIRT711833)
- hsa-mir-3160-5p (MIRT711834)
- hsa-mir-302d-5p (MIRT711835)
- hsa-mir-302b-5p (MIRT711836)
- hsa-mir-4251 (MIRT711837)
- hsa-mir-135b-5p (MIRT711838)
- hsa-mir-135a-5p (MIRT711839)
- hsa-mir-590-3p (MIRT711840)
- hsa-mir-6772-3p (MIRT711841)
- hsa-mir-4713-5p (MIRT711842)
- hsa-mir-7111-3p (MIRT711843)
- hsa-mir-1251-3p (MIRT711844)
- hsa-mir-4448 (MIRT711845)
- hsa-mir-4268 (MIRT711846)
- hsa-mir-2116-3p (MIRT711847)
- hsa-mir-532-3p (MIRT711848)
- hsa-mir-150-5p (MIRT711849)
- hsa-mir-6769b-3p (MIRT711850)
- hsa-mir-4723-3p (MIRT711851)
- hsa-mir-3183 (MIRT711852)
- hsa-mir-186-3p (MIRT711853)
miRNA Products
- Search ViGene Biosciences for AMOTL2
Inhibitory RNA Products
- Origene shRNA, siRNA, and RNAi products in human, mouse, rat for AMOTL2
- Browse OriGene Inhibitory RNA Products For AMOTL2
-
ViGene Biosciences ready-to-package AAV shRNAs for AMOTL2 gene
Clone Products
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for AMOTL2
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for AMOTL2
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Cell Line Products
-
Horizon Cell Lines for AMOTL2
-
ViGene Biosciences adenoviral particle packaged cDNA for AMOTL2 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for AMOTL2 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for AMOTL2 gene
Flow Cytometry Products
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for AMOTL2 Gene
Localization for AMOTL2 Gene
Subcellular locations from UniProtKB/Swiss-Prot for AMOTL2 Gene
- Recycling endosome.
| Compartment | Confidence |
|---|---|
| cytosol | 5 |
| plasma membrane | 4 |
| nucleus | 4 |
| cytoskeleton | 3 |
| endosome | 3 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005768 | endosome | IEA | -- |
| GO:0005829 | cytosol | TAS | -- |
| GO:0005923 | bicellular tight junction | IEA | -- |
| GO:0016324 | apical plasma membrane | IEA | -- |
| GO:0031410 | cytoplasmic vesicle | IEA | -- |
Pathways & Interactions for AMOTL2 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Tight junction | ||
| 2 | Signaling by GPCR | ||
| 3 | Signaling by Hippo | ||
Pathways by source for AMOTL2 Gene
2 Reactome pathways for AMOTL2 Gene
1 KEGG pathway for AMOTL2 Gene
Interacting Proteins for AMOTL2 Gene
Selected Interacting proteins:
Q9Y2J4-AMOL2_HUMAN
ENSP00000249883
for AMOTL2 Gene via
IID
UniProtKB
STRING
MINT
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0016055 | Wnt signaling pathway | IEA | -- |
| GO:0035329 | hippo signaling | TAS | -- |
No data available for SIGNOR curated interactions for AMOTL2 Gene
Transcripts for AMOTL2 Gene
mRNA/cDNA for AMOTL2 Gene
- (8) REFSEQ mRNAs :
- (9) Additional mRNA sequences :
- (214) Selected AceView cDNA sequences:
- (13) Ensembl transcripts including schematic representations, and UCSC links where relevant :
CRISPR Products
-
OriGene CRISPR knockouts for AMOTL2
-
Santa Cruz Biotechnology (SCBT) CRISPR for AMOTL2
- GenScript: Design CRISPR guide RNA sequences for AMOTL2
miRNA Products
- Search ViGene Biosciences for AMOTL2
Inhibitory RNA Products
- Origene shRNA, siRNA, and RNAi products in human, mouse, rat for AMOTL2
- Browse OriGene Inhibitory RNA Products For AMOTL2
-
ViGene Biosciences ready-to-package AAV shRNAs for AMOTL2 gene
Clone Products
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for AMOTL2
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for AMOTL2
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Flow Cytometry Products
| ExUns: | 1a | · | 1b | · | 1c | ^ | 2 | ^ | 3 | ^ | 4a | · | 4b | · | 4c | · | 4d | ^ | 5a | · | 5b | · | 5c | · | 5d | · | 5e | ^ | 6a | · | 6b | · | 6c | ^ | 7a | · | 7b | · | 7c | ^ | 8 | ^ | 9a | · | 9b | ^ | 10 | ^ | 11a | · | 11b | ^ |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||
| SP2: | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||
| SP3: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
| SP4: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
| SP5: | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||
| SP6: | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||
| SP7: | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||
| SP8: | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||
| SP9: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP10: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP11: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP12: | - |
| ExUns: | 12a | · | 12b | ^ | 13a | · | 13b | · | 13c |
|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | ||||||||
| SP2: | - | ||||||||
| SP3: | - | ||||||||
| SP4: | - | ||||||||
| SP5: | |||||||||
| SP6: | |||||||||
| SP7: | |||||||||
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| SP10: | |||||||||
| SP11: | |||||||||
| SP12: |
Expression for AMOTL2 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Epiblast (Early Embryonic Tissues)
- Primordial Germ Cell Precursors Epiblast
-
Gonad
- Primordial Germ Cell Precursors Epiblast
-
Somite (Muscoskeletal System)
- Muscle Progenitor Cells Thoracic Ventrolateral Dermomyotome Lip
-
Skeletal Muscle (Muscoskeletal System)
- Muscle Progenitor Cells Thoracic Ventrolateral Dermomyotome Lip
-
Adipose (Muscoskeletal System)
This gene is overexpressed in Placenta (28.5), Heart (12.2), Adipocyte (11.8), and Peripheral blood mononuclear cells (8.3).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for AMOTL2 Gene
NURSA nuclear receptor signaling pathways regulating expression of AMOTL2 Gene:
AMOTL2SOURCE GeneReport for Unigene cluster for AMOTL2 Gene:
Hs.426312Evidence on tissue expression from TISSUES for AMOTL2 Gene
- Nervous system(4.9)
- Kidney(4.3)
- Liver(4.2)
Primer Products
-
OriGene qPCR primer pairs and template standards for AMOTL2
-
OriGene qPCR primer pairs for AMOTL2
No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for AMOTL2 Gene
Orthologs for AMOTL2 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | AMOTL2 34 35 |
|
||
| dog (Canis familiaris) |
Mammalia | AMOTL2 34 35 |
|
||
| cow (Bos Taurus) |
Mammalia | AMOTL2 34 35 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Amotl2 34 |
|
||
| mouse (Mus musculus) |
Mammalia | Amotl2 34 16 35 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | AMOTL2 35 |
|
OneToOne | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | AMOTL2 35 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | AMOTL2 34 35 |
|
||
| lizard (Anolis carolinensis) |
Reptilia | AMOTL2 35 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | amotl2 34 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | amotl2a 34 35 |
|
||
| amotl2b 35 |
|
OneToMany | |||
| worm (Caenorhabditis elegans) |
Secernentea | F59C12.3 35 |
|
OneToMany |
- Species where no ortholog for AMOTL2 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
Paralogs for AMOTL2 Gene
(2) SIMAP similar genes for AMOTL2 Gene using alignment to 7 proteins:
Variants for AMOTL2 Gene
| SNP ID | Clin | Chr 03 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs1000272126 | -- | 134,376,754(+) | TCTCA(A/G)TCTAC | upstream-variant-2KB | |
| rs1000307264 | -- | 134,358,554(+) | CTGCT(C/T)TCTGG | reference, missense | |
| rs1000396438 | -- | 134,364,386(+) | AGCAA(A/G)CTCCC | intron-variant | |
| rs1000448707 | -- | 134,364,024(+) | CGGGT(-/G)GGAAG | intron-variant | |
| rs1000619075 | -- | 134,360,579(+) | AGGTC(C/T)CCATA | intron-variant |
Residual Variation Intolerance Score:
94.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
4.66;
65.80% of all genes are more intolerant (likely to be disease-causing)
Relevant External Links for AMOTL2 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- AMOTL2
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for AMOTL2 Gene
Disorders for AMOTL2 Gene
Relevant External Links for AMOTL2
No disorders were found for AMOTL2 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for AMOTL2 Gene
Publications for AMOTL2 Gene
- Angiomotin belongs to a novel protein family with conserved coiled- coil and PDZ binding domains. (PMID: 12406577) Bratt A. … Holmgren L. (Gene 2002) 3 4 22 64
- Angiomotin-like2 gene (amotl2) is required for migration and proliferation of endothelial cells during angiogenesis. (PMID: 21937427) Wang Y. … Meng A. (J. Biol. Chem. 2011) 3 4 64
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
- Prediction of the coding sequences of unidentified human genes. XIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10231032) Nagase T. … Ohara O. (DNA Res. 1999) 3 4 64
Products for AMOTL2 Gene
- Browse R&D Systems for Antibodies
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- Custom Antibody ServicesOriGene Antibodies for AMOTL2
- Browse OriGene ELISA Kits
- Custom Assay Services
- OriGene Purified Proteins for AMOTL2
- Search Origene for MassSpec and Protein Over-expression Lysates for AMOTL2
- Origene Custom Protein Services for AMOTL2
- Origene shRNA, siRNA, and RNAi products in human, mouse, rat for AMOTL2
- Browse OriGene Inhibitory RNA Products For AMOTL2
- OriGene qPCR primer pairs and template standards for AMOTL2
- OriGene qPCR primer pairs for AMOTL2
- OriGene CRISPR knockouts for AMOTL2
- OriGene ORF clones in human for AMOTL2
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For AMOTL2
- GenScript: Next-day shipping cDNA ORF clone for AMOTL2 in any vector
- GenScript Custom Purified and Recombinant Proteins Services for AMOTL2
- GenScript Custom Assay Services for AMOTL2
- GenScript Custom overexpressing Cell Line Services for AMOTL2
- GenScript: Design CRISPR guide RNA sequences for AMOTL2
- Design optimal peptide antigens
- CloneReady with Over 120,000 Genes
- Gene Synthesis: Any Gene in Any Vector
- Vector-based siRNA and miRNA, Ready for Transfection
- Gene Mutant Library, Variants up to 10^11
- Plasmid Preparation
- GenScript Custom Peptide Services for AMOTL2
- Browse Sino Biological cDNA Clones
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- Novus Biologicals Antibodies for AMOTL2
- Novus Biologicals proteins and lysates for AMOTL2
- Novus Biologicals
- Novus Biologicals Tissue Microarrays
- Abcam antibodies for AMOTL2
- Abcam proteins for AMOTL2
- Search for Assays for AMOTL2 at Abcam
- Find your target
- Search knockout validated antibodies
- Browse monoclonal antibodies
- antibodies-online Antibodies for AMOTL2: See all 28
- antibodies-online Kits for AMOTL2: See all 6
- antibodies-online Proteins for AMOTL2: See all 4
- Search antibodies-online for peptides
- GeneTex AMOTL2 antibody for AMOTL2
- Search GeneTex for Proteins for AMOTL2
- ViGene Biosciences adenoviral particle packaged cDNA for AMOTL2 gene
- ViGene Biosciences lentiviral particle packaged cDNA for AMOTL2 gene
- ViGene Biosciences ready-to-package AAV shRNAs for AMOTL2 gene
- Search ViGene Biosciences for AMOTL2
- Santa Cruz Biotechnology (SCBT) Antibodies for AMOTL2
- Search Santa Cruz Biotechnology (SCBT) for AMOTL2 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for AMOTL2
- Horizon Cell Lines for AMOTL2
- Cyagen custom Knockout/knockin (KOKI) mouse models for AMOTL2
- VectorBuilder custom plasmid, inducible vectors for AMOTL2
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for AMOTL2
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Sources for AMOTL2 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
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- (21) IntAct
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- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) RNAdb
- (29) ASD
- (30) ECgene
- (31) GeneAnnot
- (32) CGAP SAGE
- (33) SOURCE
- (34) HomoloGene
- (35) PanEnsembl
- (36) euGenes
- (37) SGD
- (38) FlyBase
- (39) WormBase
- (40) Pseudogene
- (41) DGV
- (42) dbSNP
- (43) GenAtlas
- (44) GeneTests
- (45) HGMD
- (46) GAD
- (47) LSDB
- (48) BGMUT
- (49) HuGE
- (50) eBioscience
- (51) Atlas
- (52) Cell Signaling Technology
- (53) GenBank
- (54) H-invDB
- (55) HORDE
- (56) HUGE
- (57) IMGT
- (58) Leiden
- (59) MILLIPORE
- (60) miRBase
- (61) DME
- (62) NCBI
- (63) OriGene
- (64) PubMed
- (65) R&D Systems
- (66) TGDB
- (67) Tocris
- (68) Abcam
- (69) Novus
- (70) ProSpec
- (71) Sino Biological
- (72) GenScript
- (73) Qiagen
- (74) Cloud-Clone Corp.
- (75) Enzo Life Sciences
- (76) OCA
- (77) Proteopedia
- (78) MOPED
- (79) SPIRE
- (80) neXtProt
- (81) Reactome
- (82) GeneGo (Thomson Reuters)
- (83) fRNAdb
- (84) DISEASES
- (85) SIMAP
- (86) GenomeRNAi
- (87) LifeMap
- (88) miRTarBase
- (89) MalaCards
- (90) Invitrogen
- (91) BitterDB
- (92) Vector BioLabs
- (93) ESI-BIO
- (94) RefSeq
- (95) BioSystems
- (96) MaxQB
- (97) IUPHAR
- (98) BioGPS
- (99) Illumina
- (100) COMPARTMENTS
- (101) HOMER
- (102) PaxDb
- (103) ApexBio
- (104) Addgene
- (105) antibodies-online
- (106) CYP
- (107) NONCODE
- (108) SwitchGear Genomics
- (109) TreeFam
- (110) PathCards
- (111) GeneReviews
- (112) GeneTex
- (113) Taconic Biosciences
- (114) GTEx
- (115) ProteomicsDB
- (116) SCBT
- (117) DGIdb
- (118) ClinicalTrials
- (119) FDA Approved Drugs
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- (122) diseasecard
- (123) NIH Rare Diseases
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- (128) Genetics Home Reference
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- (135) Gene Damage Index
- (136) ViGene Biosciences
- (137) HPO
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- (139) VISTA
- (140) FANTOM5
- (141) ENCODE
- (142) ProSci
- (143) Horizon
- (144) NURSA
- (145) IID
- (146) Cyagen
- (147) VectorBuilder
- (148) SNPedia
- (149) BRCA Exchange
- (150) St John's Lab
- (151) CIViC
- (152) ProteoGenix
- (153) dbSUPER
- (154) TISSUES
- (155) Gene ORGANizer