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AMOTL2 Gene

protein-coding   GIFtS: 55
GCID: GC03M134074

Angiomotin Like 2

  Search for AMOTL2
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Angiomotin Like 21 2
Leman Coiled-Coil Protein1 2 3
Angiomotin-Like Protein 21 2
LCCP2 3
KIAA09893 5

External Ids:    HGNC: 178121   Entrez Gene: 514212   Ensembl: ENSG000001140197   OMIM: 6146585   UniProtKB: Q9Y2J43   

Export aliases for AMOTL2 gene to outside databases

Previous GC identifers: GC03M131013 GC03M134860 GC03M135356 GC03M135395 GC03M135556 GC03M131452


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for AMOTL2 Gene:
Angiomotin is a protein that binds angiostatin, a circulating inhibitor of the formation of new blood vessels
(angiogenesis). Angiomotin mediates angiostatin inhibition of endothelial cell migration and tube formation in
vitro. The protein encoded by this gene is related to angiomotin and is a member of the motin protein family.
Alternative splicing results in multiple transcript variants of this gene. (provided by RefSeq, Jul 2013)

GeneCards Summary for AMOTL2 Gene:
AMOTL2 (angiomotin like 2) is a protein-coding gene. GO annotations related to this gene include identical protein binding. An important paralog of this gene is AMOTL1.

UniProtKB/Swiss-Prot: AMOL2_HUMAN, Q9Y2J4
Function: Regulates the translocation of phosphorylated SRC to peripheral cell-matrix adhesion sites. Required for
proper architecture of actin filaments. Inhibits the Wnt/beta-catenin signaling pathway, probably by recruiting
CTNNB1 to recycling endosomes and hence preventing its translocation to the nucleus. Participates in
angiogenesis. May play a role in the polarity, proliferation and migration of endothelial cells. Selectively
promotes FGF-induced MAPK activation through SRC

Gene Wiki entry for AMOTL2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000003.12  NT_005612.17  NC_018914.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the AMOTL2 gene promoter:
         Max1   RFX1   SREBP-1c   IRF-1   SREBP-1b   FAC1   SREBP-1a   FOXO4   c-Myb   c-Myc   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidAMOTL2 promoter sequence
   Search Chromatin IP Primers for AMOTL2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat AMOTL2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3q21-q22   Ensembl cytogenetic band:  3q22.2   HGNC cytogenetic band: 3q21-q22

AMOTL2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
AMOTL2 gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03M134074:  view genomic region     (about GC identifiers)

Start:
134,074,190 bp from pter      End:
134,094,321 bp from pter
Size:
20,132 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: AMOL2_HUMAN, Q9Y2J4 (See protein sequence)
Recommended Name: Angiomotin-like protein 2  
Size: 779 amino acids; 85764 Da
Subunit: Interacts with SRC
Sequence caution: Sequence=AAH11454.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Sequence=BAA76833.1; Type=Erroneous initiation; Note=Translation N-terminally shortened; Sequence=BAD97318.1;
Type=Erroneous initiation; Note=Translation N-terminally shortened;
Secondary accessions: A8K6F1 B7Z5Q1 E9PHW3 Q53EP1 Q96F99 Q9UKB4
Alternative splicing: 4 isoforms:  Q9Y2J4-1   Q9Y2J4-2   Q9Y2J4-3   Q9Y2J4-4   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for AMOTL2: NX_Q9Y2J4

Explore proteomics data for AMOTL2 at MOPED

Post-translational modifications: 

  • Phosphorylation at Tyr-107 is necessary for efficient binding to SRC and synergistically functioning with SRC to
    activate the downstream MAPK pathway (By similarity)1
  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See AMOTL2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001265612.1  NP_001265614.1  NP_057285.3  

    ENSEMBL proteins: 
     ENSP00000249883   ENSP00000409999   ENSP00000424765   ENSP00000425475   ENSP00000427184  
     ENSP00000424910   ENSP00000427292   ENSP00000422658   ENSP00000427482   ENSP00000421521  
    Reactome Protein details: Q9Y2J4

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    2 InterPro protein domains:
     IPR009114 Angiomotin
     IPR024646 Angiomotin_C

    Graphical View of Domain Structure for InterPro Entry Q9Y2J4

    ProtoNet protein and cluster: Q9Y2J4

    UniProtKB/Swiss-Prot: AMOL2_HUMAN, Q9Y2J4
    Similarity: Belongs to the angiomotin family


    Find genes that share domains with AMOTL2           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: AMOL2_HUMAN, Q9Y2J4
    Function: Regulates the translocation of phosphorylated SRC to peripheral cell-matrix adhesion sites. Required for
    proper architecture of actin filaments. Inhibits the Wnt/beta-catenin signaling pathway, probably by recruiting
    CTNNB1 to recycling endosomes and hence preventing its translocation to the nucleus. Participates in
    angiogenesis. May play a role in the polarity, proliferation and migration of endothelial cells. Selectively
    promotes FGF-induced MAPK activation through SRC

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI--
    GO:0042802identical protein binding IEA--
         
    Find genes that share ontologies with AMOTL2           About GenesLikeMe


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for AMOTL2
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for AMOTL2
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    miRNA
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    miRTarBase miRNAs that target AMOTL2:
    hsa-mir-27a-3p (MIRT028729)

    Block miRNA regulation of human, mouse, rat AMOTL2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate AMOTL2 (see all 53):
    hsa-miR-3130-5p hsa-miR-3194-5p hsa-miR-429 hsa-miR-513a-5p hsa-miR-30d hsa-miR-766 hsa-miR-105 hsa-miR-9
    SwitchGear 3'UTR luciferase reporter plasmidAMOTL2 3' UTR sequence
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    GenScript: all cDNA clones in your preferred vector: AMOTL2 (NM_016201)
    Browse Sino Biological Human cDNA Clones
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for AMOTL2


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    AMOL2_HUMAN, Q9Y2J4: Recycling endosome (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol4
    nucleus3
    endosome2
    plasma membrane2

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005829cytosol TAS--
    GO:0005923tight junction IEA--
    GO:0016324apical plasma membrane IEA--
    GO:0031410cytoplasmic vesicle IEA--
    GO:0055037recycling endosome IEA--

    Find genes that share ontologies with AMOTL2           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for AMOTL2 About    
    See pathways by source

    SuperPathContained pathways About
    1Signaling by GPCR
    Signal Transduction0.58
    2Signaling by Hippo
    Signaling by Hippo


    Find genes that share SuperPaths with AMOTL2           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Reactome Pathway for AMOTL2
        Signaling by Hippo


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for AMOTL2
    Interactions:

        Search GeneGlobe Interaction Network for AMOTL2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 23)

    Selected Interacting proteins for AMOTL2 (Q9Y2J42, 3 ENSP000002498834) via UniProtKB, MINT, STRING, and/or I2D (see all 34)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ENSG00000206454Q018603I2D: score=2 
    ENSG00000229094Q018603I2D: score=2 
    ENSG00000230336Q018603I2D: score=2 
    ENSG00000233911Q018603I2D: score=2 
    ENSG00000235068Q018603I2D: score=2 
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016055Wnt signaling pathway IEA--
    GO:0035329hippo signaling TAS--

    Find genes that share ontologies with AMOTL2           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for AMOTL2 (AMOL2)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for AMOTL2 gene (3 alternative transcripts): 
    NM_001278683.1  NM_001278685.1  NM_016201.3  

    Unigene Cluster for AMOTL2:

    Angiomotin like 2
    Hs.426312  [show with all ESTs]
    Unigene Representative Sequence: NM_016201
    13 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000249883(uc003eqg.1 uc003eqh.1) ENST00000422605 ENST00000514516(uc003eqf.2)
    ENST00000506326(uc003eqe.1) ENST00000513145 ENST00000512955 ENST00000511759
    ENST00000510560 ENST00000504234 ENST00000505596 ENST00000506107 ENST00000515172
    ENST00000502491
    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate AMOTL2 (see all 53):
    hsa-miR-3130-5p hsa-miR-3194-5p hsa-miR-429 hsa-miR-513a-5p hsa-miR-30d hsa-miR-766 hsa-miR-105 hsa-miR-9
    SwitchGear 3'UTR luciferase reporter plasmidAMOTL2 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat AMOTL2
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    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: AMOTL2 (NM_016201)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for AMOTL2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat AMOTL2
    Primer
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat AMOTL2
      QuantiTect SYBR Green Assays in human, mouse, rat AMOTL2
      QuantiFast Probe-based Assays in human, mouse, rat AMOTL2

    Additional mRNA sequence: 

    AB023206.1 AF175966.1 AK001343.1 AK074731.1 AK223598.1 AK291616.1 AK299270.1 BC011454.1 
    BC025981.2 

    12 DOTS entries:

    DT.447894  DT.100819952  DT.120914998  DT.120915014  DT.75165614  DT.120915029  DT.120915027  DT.99938361 
    DT.100819949  DT.102824642  DT.120914994  DT.40235770 

    Selected AceView cDNA sequences (see all 214):

    BU682537 AW003382 T59967 CD514256 AK001343 CB988092 AI561222 AI299504 
    AA341373 AA897220 AW104853 AU124500 BQ183597 CR614830 AA341416 BQ008752 
    CB960406 BF222982 CA444510 CB126308 BM979351 AA365287 BQ448483 AI214560 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for AMOTL2 (see all 12)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b · 4c · 4d ^ 5a · 5b · 5c · 5d · 5e ^ 6a · 6b · 6c ^ 7a · 7b · 7c ^ 8 ^ 9a · 9b ^ 10 ^ 11a · 11b ^
    SP1:                    -     -                                                                             -                                         -         
    SP2:                    -     -                                                                             -                                         -         
    SP3:                                                                                                        -                                         -         
    SP4:                                                                                                                                                  -         
    SP5:                    -     -                 -     -     -     -     -     -     -     -     -     -     -     -                                             

    ExUns: 12a · 12b ^ 13a · 13b · 13c
    SP1:        -                     
    SP2:        -                     
    SP3:        -                     
    SP4:        -                     
    SP5:                              


    ECgene alternative splicing isoforms for AMOTL2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    AMOTL2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GCTGTTTTGT
    AMOTL2 Expression
    About this image


    AMOTL2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 3) fully expand
     
     Skeletal Muscle (Muscoskeletal System)
             Muscle Progenitor Cells Thoracic Ventrolateral Dermomyotome Lip
     
     Somite (Muscoskeletal System)
             Muscle Progenitor Cells Thoracic Ventrolateral Dermomyotome Lip
     
     Adipose (Muscoskeletal System)
    AMOTL2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    AMOTL2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.426312
        Custom PCR Arrays for AMOTL2
    Primer
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    QuantiFast Probe-based Assays in human, mouse, rat AMOTL2
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for AMOTL2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for AMOTL2 gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Amotl21 , 5 angiomotin-like 21, 5 85.19(n)1
    89.09(a)1
      9 (54.71 cM)5
    563321  NM_019764.21  NP_062738.21 
     1027166725 
    chicken
    (Gallus gallus)
    Aves AMOTL21 angiomotin like 2 71.01(n)
    70.71(a)
      424863  XM_004936992.1  XP_004937049.1 
    lizard
    (Anolis carolinensis)
    Reptilia AMOTL26
    angiomotin like 2
    61(a)
    1 ↔ 1
    3(31363088-31384361)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia amotl21 angiomotin like 2 64.26(n)
    64.21(a)
      100379727  XM_002935086.2  XP_002935132.2 
    zebrafish
    (Danio rerio)
    Actinopterygii amotl2a1 angiomotin like 2a 58.35(n)
    56.03(a)
      558920  NM_001080177.1  NP_001073646.1 
    worm
    (Caenorhabditis elegans)
    Secernentea F59C12.36
    Protein F59C12.3 (F59C12.3) mRNA, complete cds
    19(a)
    1 → many
    X(16603386-16609524) WBGene00019102


    ENSEMBL Gene Tree for AMOTL2 (if available)
    TreeFam Gene Tree for AMOTL2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for AMOTL2 gene
    AMOTL12  AMOT2  
    2 SIMAP similar genes for AMOTL2 using alignment to 7 protein entries:     AMOL2_HUMAN (see all proteins):
    AMOT    AMOTL1

    Find genes that share paralogs with AMOTL2           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for AMOTL2 (see all 526)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 3 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1498122441,2
    --134073762(+) CTGGAA/GGGTTG 1 -- ds50010--------
    rs1448444431,2
    --134073916(+) GCTGGC/TAGGCC 1 -- ds50010--------
    rs1896052871,2
    --134074099(+) TGCTGA/GCCACA 1 -- ds50010--------
    rs778203131,2
    C--134074279(+) GAGGCG/AGTGGC 1 -- ut312Minor allele frequency- A:0.30CSA WA 120
    rs1808475581,2
    --134074293(+) GAACAC/TGCACA 1 -- ut310--------
    rs1137063921,2
    C,F--134074332(+) GCCTTC/GTGGAT 1 -- ut312Minor allele frequency- G:0.03CSA WA 120
    rs76393801,2
    C,F--134074445(+) GTGTGG/CCCGAA 1 -- ut31 ese32Minor allele frequency- C:0.16WA 120
    rs1861338411,2
    --134074479(+) TACCTC/TGGGAG 1 -- ut310--------
    rs1892295581,2
    --134074636(+) GAGATG/TGGACT 1 -- ut310--------
    rs123171,2
    C,F,H--134074730(+) TTATTT/ATTTTT 1 -- ut312Minor allele frequency- A:0.13NA 122

    HapMap Linkage Disequilibrium report for AMOTL2 (134074190 - 134094321 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for AMOTL2: --
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing AMOTL2
    DNA2.0 Custom Variant and Variant Library Synthesis for AMOTL2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 614658    OMIM disorders: --


    Find genes that share disorders with AMOTL2           About GenesLikeMe

    Genetic Association Database (GAD): AMOTL2

    Export disorders for AMOTL2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for AMOTL2 gene, integrated from 10 sources (see all 31):
    (articles sorted by number of sources associating them with AMOTL2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Angiomotin belongs to a novel protein family with conserved coiled- coil and PDZ binding domains. (PubMed id 12406577)1, 2, 9 Bratt A.... Holmgren L. (Gene 2002)
    2. Angiomotin-like2 gene (amotl2) is required for migration and proliferation of endothelial cells during angiogenesis. (PubMed id 21937427)1, 2 Wang Y.... Meng A. (J. Biol. Chem. 2011)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    5. Prediction of the coding sequences of unidentified human genes. XIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10231032)1, 2 Nagase T.... Ohara O. (DNA Res. 1999)
    6. AMOTL2 interaction with TAZ causes the inhibition of surfactant proteins expression in lung cells. (PubMed id 23911299)1 Lucci V....Zannini M. (Gene 2013)
    7. Amot130 adapts atrophin-1 interacting protein 4 to inhibit yes-associated protein signaling and cell growth. (PubMed id 23564455)1 Adler J.J....Wells C.D. (J. Biol. Chem. 2013)
    8. Amotl2 interacts with LL5I^, localizes to podosomes and regulates postsynaptic differentiation in muscle. (PubMed id 23525008)1 Proszynski T.J. and Sanes J.R. (J. Cell. Sci. 2013)
    9. The SOX2-interactome in brain cancer cells identifies the requirement of MSI2 and USP9X for the growth of brain tumor cells. (PubMed id 23667531)1 Cox J.L....Rizzino A. (PLoS ONE 2013)
    10. Protein interaction network of the mammalian Hippo pathway reveals mechanisms of kinase-phosphatase interactions. (PubMed id 24255178)1 Couzens A.L....Gingras A.C. (Sci Signal 2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 51421 HGNC: 17812 AceView: AMOTL2 Ensembl:ENSG00000114019 euGenes: HUgn51421
    ECgene: AMOTL2 H-InvDB: AMOTL2

    (According to HUGE)
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    HUGE: KIAA0989

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for AMOTL2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for AMOTL2 gene:
    Search GeneIP for patents involving AMOTL2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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