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Aliases for AMOTL2 Gene

Aliases for AMOTL2 Gene

  • Angiomotin Like 2 2 3 5
  • Leman Coiled-Coil Protein 2 3 4
  • Angiomotin-Like Protein 2 2 3
  • LCCP 3 4
  • KIAA0989 4

External Ids for AMOTL2 Gene

Previous GeneCards Identifiers for AMOTL2 Gene

  • GC03M131013
  • GC03M134860
  • GC03M135356
  • GC03M135395
  • GC03M135556
  • GC03M134074
  • GC03M131452

Summaries for AMOTL2 Gene

Entrez Gene Summary for AMOTL2 Gene

  • Angiomotin is a protein that binds angiostatin, a circulating inhibitor of the formation of new blood vessels (angiogenesis). Angiomotin mediates angiostatin inhibition of endothelial cell migration and tube formation in vitro. The protein encoded by this gene is related to angiomotin and is a member of the motin protein family. Alternative splicing results in multiple transcript variants of this gene. [provided by RefSeq, Jul 2013]

GeneCards Summary for AMOTL2 Gene

AMOTL2 (Angiomotin Like 2) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Tight junction. GO annotations related to this gene include identical protein binding. An important paralog of this gene is AMOTL1.

UniProtKB/Swiss-Prot for AMOTL2 Gene

  • Regulates the translocation of phosphorylated SRC to peripheral cell-matrix adhesion sites. Required for proper architecture of actin filaments. Inhibits the Wnt/beta-catenin signaling pathway, probably by recruiting CTNNB1 to recycling endosomes and hence preventing its translocation to the nucleus. Participates in angiogenesis. May play a role in the polarity, proliferation and migration of endothelial cells. Selectively promotes FGF-induced MAPK activation through SRC.

Gene Wiki entry for AMOTL2 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for AMOTL2 Gene

Genomics for AMOTL2 Gene

Regulatory Elements for AMOTL2 Gene

Enhancers for AMOTL2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH03G134322 1.9 FANTOM5 Ensembl ENCODE dbSUPER 17.8 +45.2 45229 15.1 PKNOX1 FOXA2 ARNT ARID4B SIN3A ZBTB7B FOS DEK SP5 REST AMOTL2 ENSG00000260633 TFP1 ANAPC13 LOC105374118
GH03G134340 1 Ensembl dbSUPER 11.9 +34.5 34479 0.4 ELF3 SOX13 SAP130 ARID4B ZSCAN9 ZNF644 RARA ZFHX2 RERE NR2F6 AMOTL2 ANAPC13 ENSG00000260633 LOC105374118
GH03G134299 0.6 Ensembl 11.2 +75.9 75878 0.4 CTCF PKNOX1 PBX2 SMC3 PRDM1 RAD21 NR2F2 AMOTL2 CEP63 ANAPC13 RYK ENSG00000260633 LINC02004
GH03G134347 1.9 FANTOM5 Ensembl ENCODE dbSUPER 3.5 +13.6 13638 29.3 HDGF PKNOX1 FOXA2 ARID4B SIN3A DMAP1 FEZF1 ZNF2 ZBTB7B YY1 ENSG00000260633 TFP1 RYK RAB6B AMOTL2 RPL39P5 MIR6827
GH03G134393 0.4 dbSUPER 12.1 -20.2 -20216 3.5 NFE2 NR2F2 AMOTL2 HMGN1P9 ANAPC13 CEP63 ENSG00000260633 HMGB3P13
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around AMOTL2 on UCSC Golden Path with GeneCards custom track

Promoters for AMOTL2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000158716 1479 2401 ARID4B SIN3A FEZF1 DMAP1 ZNF2 ZBTB7B FOS DEK ZNF263 SP3

Genomic Location for AMOTL2 Gene

Chromosome:
3
Start:
134,355,345 bp from pter
End:
134,375,479 bp from pter
Size:
20,135 bases
Orientation:
Minus strand

Genomic View for AMOTL2 Gene

Genes around AMOTL2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
AMOTL2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for AMOTL2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for AMOTL2 Gene

Proteins for AMOTL2 Gene

  • Protein details for AMOTL2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y2J4-AMOL2_HUMAN
    Recommended name:
    Angiomotin-like protein 2
    Protein Accession:
    Q9Y2J4
    Secondary Accessions:
    • A8K6F1
    • B7Z5Q1
    • E9PHW3
    • Q53EP1
    • Q96F99
    • Q9UKB4

    Protein attributes for AMOTL2 Gene

    Size:
    779 amino acids
    Molecular mass:
    85764 Da
    Quaternary structure:
    • Interacts with SRC.
    SequenceCaution:
    • Sequence=AAH11454.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAA76833.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=BAD97318.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for AMOTL2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for AMOTL2 Gene

Post-translational modifications for AMOTL2 Gene

  • Phosphorylation at Tyr-107 is necessary for efficient binding to SRC and synergistically functioning with SRC to activate the downstream MAPK pathway.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for AMOTL2 Gene

Domains & Families for AMOTL2 Gene

Protein Domains for AMOTL2 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for AMOTL2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9Y2J4

UniProtKB/Swiss-Prot:

AMOL2_HUMAN :
  • Belongs to the angiomotin family.
Family:
  • Belongs to the angiomotin family.
genes like me logo Genes that share domains with AMOTL2: view

No data available for Gene Families for AMOTL2 Gene

Function for AMOTL2 Gene

Molecular function for AMOTL2 Gene

UniProtKB/Swiss-Prot Function:
Regulates the translocation of phosphorylated SRC to peripheral cell-matrix adhesion sites. Required for proper architecture of actin filaments. Inhibits the Wnt/beta-catenin signaling pathway, probably by recruiting CTNNB1 to recycling endosomes and hence preventing its translocation to the nucleus. Participates in angiogenesis. May play a role in the polarity, proliferation and migration of endothelial cells. Selectively promotes FGF-induced MAPK activation through SRC.

Gene Ontology (GO) - Molecular Function for AMOTL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 16189514
GO:0042802 identical protein binding IEA --
genes like me logo Genes that share ontologies with AMOTL2: view

Phenotypes for AMOTL2 Gene

genes like me logo Genes that share phenotypes with AMOTL2: view

Animal Model Products

CRISPR Products

miRNA for AMOTL2 Gene

miRTarBase miRNAs that target AMOTL2

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for AMOTL2 Gene

Localization for AMOTL2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for AMOTL2 Gene

Recycling endosome.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for AMOTL2 gene
Compartment Confidence
cytosol 5
plasma membrane 4
nucleus 4
cytoskeleton 3
endosome 3

Gene Ontology (GO) - Cellular Components for AMOTL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005768 endosome IEA --
GO:0005829 cytosol TAS --
GO:0005923 bicellular tight junction IEA --
GO:0016324 apical plasma membrane IEA --
GO:0031410 cytoplasmic vesicle IEA --
genes like me logo Genes that share ontologies with AMOTL2: view

Pathways & Interactions for AMOTL2 Gene

genes like me logo Genes that share pathways with AMOTL2: view

Pathways by source for AMOTL2 Gene

2 Reactome pathways for AMOTL2 Gene
1 KEGG pathway for AMOTL2 Gene

Gene Ontology (GO) - Biological Process for AMOTL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016055 Wnt signaling pathway IEA --
GO:0035329 hippo signaling TAS --
genes like me logo Genes that share ontologies with AMOTL2: view

No data available for SIGNOR curated interactions for AMOTL2 Gene

Drugs & Compounds for AMOTL2 Gene

No Compound Related Data Available

Transcripts for AMOTL2 Gene

Unigene Clusters for AMOTL2 Gene

Angiomotin like 2:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for AMOTL2 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b · 4c · 4d ^ 5a · 5b · 5c · 5d · 5e ^ 6a · 6b · 6c ^ 7a · 7b · 7c ^ 8 ^ 9a · 9b ^ 10 ^ 11a · 11b ^
SP1: - - - -
SP2: - - - -
SP3: - -
SP4: -
SP5: - - - - - - - - - - - - - -
SP6: - - - - - - - -
SP7: - - - - - -
SP8: - - - - -
SP9:
SP10:
SP11:
SP12: -

ExUns: 12a · 12b ^ 13a · 13b · 13c
SP1: -
SP2: -
SP3: -
SP4: -
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:

Relevant External Links for AMOTL2 Gene

GeneLoc Exon Structure for
AMOTL2
ECgene alternative splicing isoforms for
AMOTL2

Expression for AMOTL2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for AMOTL2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for AMOTL2 Gene

This gene is overexpressed in Placenta (28.5), Heart (12.2), Adipocyte (11.8), and Peripheral blood mononuclear cells (8.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for AMOTL2 Gene



Protein tissue co-expression partners for AMOTL2 Gene

NURSA nuclear receptor signaling pathways regulating expression of AMOTL2 Gene:

AMOTL2

SOURCE GeneReport for Unigene cluster for AMOTL2 Gene:

Hs.426312

Evidence on tissue expression from TISSUES for AMOTL2 Gene

  • Nervous system(4.9)
  • Kidney(4.3)
  • Liver(4.2)
genes like me logo Genes that share expression patterns with AMOTL2: view

Primer Products

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for AMOTL2 Gene

Orthologs for AMOTL2 Gene

This gene was present in the common ancestor of animals.

Orthologs for AMOTL2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia AMOTL2 34 35
  • 99.62 (n)
dog
(Canis familiaris)
Mammalia AMOTL2 34 35
  • 89.19 (n)
cow
(Bos Taurus)
Mammalia AMOTL2 34 35
  • 87.63 (n)
rat
(Rattus norvegicus)
Mammalia Amotl2 34
  • 85.71 (n)
mouse
(Mus musculus)
Mammalia Amotl2 34 16 35
  • 85.19 (n)
oppossum
(Monodelphis domestica)
Mammalia AMOTL2 35
  • 67 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia AMOTL2 35
  • 52 (a)
OneToOne
chicken
(Gallus gallus)
Aves AMOTL2 34 35
  • 71.01 (n)
lizard
(Anolis carolinensis)
Reptilia AMOTL2 35
  • 61 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia amotl2 34
  • 64.26 (n)
zebrafish
(Danio rerio)
Actinopterygii amotl2a 34 35
  • 58.35 (n)
amotl2b 35
  • 42 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea F59C12.3 35
  • 19 (a)
OneToMany
Species where no ortholog for AMOTL2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for AMOTL2 Gene

ENSEMBL:
Gene Tree for AMOTL2 (if available)
TreeFam:
Gene Tree for AMOTL2 (if available)

Paralogs for AMOTL2 Gene

Paralogs for AMOTL2 Gene

(2) SIMAP similar genes for AMOTL2 Gene using alignment to 7 proteins:

genes like me logo Genes that share paralogs with AMOTL2: view

Variants for AMOTL2 Gene

Sequence variations from dbSNP and Humsavar for AMOTL2 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs1000272126 -- 134,376,754(+) TCTCA(A/G)TCTAC upstream-variant-2KB
rs1000307264 -- 134,358,554(+) CTGCT(C/T)TCTGG reference, missense
rs1000396438 -- 134,364,386(+) AGCAA(A/G)CTCCC intron-variant
rs1000448707 -- 134,364,024(+) CGGGT(-/G)GGAAG intron-variant
rs1000619075 -- 134,360,579(+) AGGTC(C/T)CCATA intron-variant

Variation tolerance for AMOTL2 Gene

Residual Variation Intolerance Score: 94.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.66; 65.80% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for AMOTL2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
AMOTL2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for AMOTL2 Gene

Disorders for AMOTL2 Gene

Relevant External Links for AMOTL2

Genetic Association Database (GAD)
AMOTL2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
AMOTL2

No disorders were found for AMOTL2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for AMOTL2 Gene

Publications for AMOTL2 Gene

  1. Angiomotin belongs to a novel protein family with conserved coiled- coil and PDZ binding domains. (PMID: 12406577) Bratt A. … Holmgren L. (Gene 2002) 3 4 22 64
  2. Angiomotin-like2 gene (amotl2) is required for migration and proliferation of endothelial cells during angiogenesis. (PMID: 21937427) Wang Y. … Meng A. (J. Biol. Chem. 2011) 3 4 64
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  5. Prediction of the coding sequences of unidentified human genes. XIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10231032) Nagase T. … Ohara O. (DNA Res. 1999) 3 4 64

Products for AMOTL2 Gene

Sources for AMOTL2 Gene

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