Aliases for AMOTL1 Gene
Aliases for AMOTL1 Gene
External Ids for AMOTL1 Gene
- HGNC: 17811
- Entrez Gene: 154810
- Ensembl: ENSG00000166025
- OMIM: 614657
- UniProtKB: Q8IY63
Previous GeneCards Identifiers for AMOTL1 Gene
- GC11P096831
- GC11P096010
- GC11P094189
- GC11P094141
- GC11P094501
- GC11P090566
- GC11P094441
Summaries for AMOTL1 Gene
-
The protein encoded by this gene is a peripheral membrane protein that is a component of tight junctions or TJs. TJs form an apical junctional structure and act to control paracellular permeability and maintain cell polarity. This protein is related to angiomotin, an angiostatin binding protein that regulates endothelial cell migration and capillary formation. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2014]
GeneCards Summary for AMOTL1 Gene
AMOTL1 (Angiomotin Like 1) is a Protein Coding gene. Diseases associated with AMOTL1 include Splenic Marginal Zone Lymphoma. Among its related pathways are Signaling by GPCR and Tight junction. GO annotations related to this gene include identical protein binding. An important paralog of this gene is AMOT.
UniProtKB/Swiss-Prot for AMOTL1 Gene
-
Inhibits the Wnt/beta-catenin signaling pathway, probably by recruiting CTNNB1 to recycling endosomes and hence preventing its translocation to the nucleus.
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for AMOTL1 Gene
Genomics for AMOTL1 Gene
Regulatory Elements for AMOTL1 Gene
| GeneHancer Identifier | Enhancer Score | Enhancer Sources | Gene-Enhancer Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites within enhancer | Gene Targets for Enhancer |
|---|---|---|---|---|---|---|---|---|
| GH11G094729 | 1.5 | Ensembl ENCODE dbSUPER | 15.4 | +26.2 | 26223 | 6.1 | ATF1 TCF12 GATA2 FOS JUNB MAFF SMARCA4 ZNF585B GLIS1 STAT3 | AMOTL1 KDM4E LOC105369438 |
| GH11G094745 | 1.7 | FANTOM5 Ensembl ENCODE dbSUPER | 12.8 | +43.7 | 43680 | 8.6 | PKNOX1 ZSCAN4 RAD21 ZNF121 ZNF766 GATA2 FOS NFYA CEBPB NR2F2 | AMOTL1 ENSG00000256469 GC11M094750 LOC105369438 |
| GH11G094785 | 1.4 | Ensembl ENCODE dbSUPER | 10.8 | +82.4 | 82421 | 6.5 | PKNOX1 RAD21 ZNF366 SCRT2 CREM EGR2 ZNF654 REST ZEB2 ZNF843 | ENSG00000256469 AMOTL1 GC11M094788 GC11M094750 |
| GH11G094648 | 1.2 | FANTOM5 Ensembl ENCODE | 11.3 | -55.1 | -55118 | 5.6 | SCRT1 TEAD4 CEBPB CHD1 RBBP5 CEBPG ETS1 HDAC2 POLR2A FOXK2 | ENSG00000255666 AMOTL1 LOC105369438 KDM4E GC11M094652 GC11M094645 |
| GH11G094727 | 0.6 | dbSUPER | 18.1 | +22.0 | 21976 | 2.3 | MAFG BACH1 CEBPB ZNF316 NFE2L1 NFE2 MAFK EMSY NFE2L2 | AMOTL1 KDM4E LOC105369438 |
Regulatory Element Products
Genomic Location for AMOTL1 Gene
- Chromosome:
- 11
- Start:
- 94,706,431 bp from pter
- End:
- 94,876,753 bp from pter
- Size:
- 170,323 bases
- Orientation:
- Plus strand
Genomic View for AMOTL1 Gene
- Cytogenetic band:
-
- 11q21 by Ensembl
- 11q21 by Entrez Gene
- 11q21 by HGNC
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for AMOTL1 Gene
Proteins for AMOTL1 Gene
-
Protein details for AMOTL1 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q8IY63-AMOL1_HUMAN
- Recommended name:
- Angiomotin-like protein 1
- Protein Accession:
- Q8IY63
- Q63HK7
- Q8NDN0
- Q8TEN8
- Q8WXD1
- Q96CM5
Protein attributes for AMOTL1 Gene
- Size:
- 956 amino acids
- Molecular mass:
- 106574 Da
- Quaternary structure:
- No Data Available
- SequenceCaution:
-
- Sequence=BAB84910.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=BAB84910.1; Type=Frameshift; Positions=592, 944; Evidence={ECO:0000305};
Protein Expression for AMOTL1 Gene
Post-translational modifications for AMOTL1 Gene
- Polyubiquitinated by NEDD4, leading to proteasomal degradation.
- Ubiquitination at Lys195, Lys227, posLast=302302, and Lys625
- Modification sites at PhosphoSitePlus
Other Protein References for AMOTL1 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
-
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-
Abcam antibodies for AMOTL1
- Invitrogen Antibodies for AMOTL1
- antibodies-online Antibodies for AMOTL1: See all 34
- GeneTex AMOTL1 antibody for AMOTL1
Protein Products
-
OriGene Purified Proteins for AMOTL1
- Search Origene for MassSpec and Protein Over-expression Lysates for AMOTL1
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- Search GeneTex for Proteins for AMOTL1
Assay Products
- antibodies-online Kits for AMOTL1: See all 6
No data available for DME Specific Peptides for AMOTL1 Gene
Domains & Families for AMOTL1 Gene
Protein Domains for AMOTL1 Gene
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for AMOTL1 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q8IY63- Family:
-
- Belongs to the angiomotin family.
No data available for Gene Families for AMOTL1 Gene
Function for AMOTL1 Gene
Molecular function for AMOTL1 Gene
- UniProtKB/Swiss-Prot Function:
- Inhibits the Wnt/beta-catenin signaling pathway, probably by recruiting CTNNB1 to recycling endosomes and hence preventing its translocation to the nucleus.
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005515 | protein binding | IPI | 21187284 |
| GO:0042802 | identical protein binding | IDA | 16019084 |
Phenotypes for AMOTL1 Gene
Animal Model Products
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-
-
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-
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CRISPR Products
-
OriGene CRISPR knockouts for AMOTL1
-
Santa Cruz Biotechnology (SCBT) CRISPR for AMOTL1
- GenScript: Design CRISPR guide RNA sequences for AMOTL1
miRNA for AMOTL1 Gene
- miRTarBase miRNAs that target AMOTL1
-
- hsa-mir-484 (MIRT042034)
- hsa-mir-23b-3p (MIRT046290)
- hsa-mir-92a-3p (MIRT049611)
- hsa-mir-15a-5p (MIRT061244)
- hsa-mir-16-5p (MIRT061245)
- hsa-mir-15b-5p (MIRT061246)
- hsa-mir-124-3p (MIRT061247)
- hsa-mir-125b-2-3p (MIRT061248)
- hsa-mir-195-5p (MIRT061249)
- hsa-mir-424-5p (MIRT061250)
- hsa-mir-497-5p (MIRT061251)
- hsa-mir-506-3p (MIRT061252)
- hsa-mir-545-3p (MIRT061253)
- hsa-mir-3125 (MIRT061254)
- hsa-mir-3148 (MIRT061255)
- hsa-mir-3916 (MIRT061256)
- hsa-mir-4428 (MIRT061257)
- hsa-mir-4477a (MIRT061259)
- hsa-mir-4503 (MIRT061260)
- hsa-mir-5582-5p (MIRT061261)
- hsa-mir-6792-5p (MIRT061263)
- hsa-mir-6838-5p (MIRT061264)
- hsa-mir-6859-5p (MIRT061265)
- hsa-mir-373-5p (MIRT241595)
- hsa-mir-616-5p (MIRT241596)
- hsa-mir-651-3p (MIRT241597)
- hsa-mir-4326 (MIRT241598)
- hsa-mir-4691-5p (MIRT241599)
- hsa-mir-371b-5p (MIRT241600)
- hsa-mir-5193 (MIRT241601)
- hsa-mir-6749-3p (MIRT241602)
- hsa-mir-6792-3p (MIRT241603)
- hsa-let-7c-3p (MIRT241604)
- hsa-mir-16-2-3p (MIRT241605)
- hsa-mir-195-3p (MIRT241606)
- hsa-mir-338-5p (MIRT241607)
- hsa-mir-4729 (MIRT334550)
- hsa-mir-9-5p (MIRT482004)
- hsa-mir-4795-3p (MIRT539297)
- hsa-mir-3924 (MIRT539298)
- hsa-mir-7151-5p (MIRT539299)
- hsa-mir-3910 (MIRT539300)
- hsa-mir-3714 (MIRT539301)
- hsa-mir-7106-3p (MIRT539302)
- hsa-mir-7113-3p (MIRT539303)
- hsa-mir-1266-3p (MIRT539304)
- hsa-mir-660-3p (MIRT539305)
- hsa-mir-339-5p (MIRT539306)
- hsa-mir-574-5p (MIRT647766)
- hsa-mir-6867-5p (MIRT647767)
- hsa-mir-4703-3p (MIRT647768)
- hsa-mir-4659b-3p (MIRT723611)
- hsa-mir-4659a-3p (MIRT723612)
- hsa-mir-6875-3p (MIRT723613)
- hsa-mir-6881-3p (MIRT723614)
- hsa-mir-6780a-3p (MIRT723615)
- hsa-mir-7111-3p (MIRT723616)
miRNA Products
- Search ViGene Biosciences for AMOTL1
Inhibitory RNA Products
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-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Cell Line Products
-
Horizon Cell Lines for AMOTL1
-
ViGene Biosciences adenoviral particle packaged cDNA for AMOTL1 gene
-
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-
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Flow Cytometry Products
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for AMOTL1 Gene
Localization for AMOTL1 Gene
Subcellular locations from UniProtKB/Swiss-Prot for AMOTL1 Gene
- Cell junction, tight junction.
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005829 | cytosol | TAS | -- |
| GO:0005923 | bicellular tight junction | IDA | 16019084 |
| GO:0008180 | colocalizes_with COP9 signalosome | IDA | 18850735 |
| GO:0016324 | apical plasma membrane | IEA | -- |
| GO:0030027 | lamellipodium | IEA | -- |
Pathways & Interactions for AMOTL1 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Tight junction | ||
| 2 | Signaling by GPCR | ||
| 3 | Signaling by Hippo | ||
Pathways by source for AMOTL1 Gene
2 Reactome pathways for AMOTL1 Gene
1 KEGG pathway for AMOTL1 Gene
Interacting Proteins for AMOTL1 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0003365 | establishment of cell polarity involved in ameboidal cell migration | IEA | -- |
| GO:0016055 | Wnt signaling pathway | IEA | -- |
| GO:0035329 | hippo signaling | TAS | -- |
| GO:0043536 | positive regulation of blood vessel endothelial cell migration | IEA | -- |
No data available for SIGNOR curated interactions for AMOTL1 Gene
Transcripts for AMOTL1 Gene
mRNA/cDNA for AMOTL1 Gene
- (7) REFSEQ mRNAs :
- (11) Additional mRNA sequences :
- (227) Selected AceView cDNA sequences:
- (5) Ensembl transcripts including schematic representations, and UCSC links where relevant :
CRISPR Products
-
OriGene CRISPR knockouts for AMOTL1
-
Santa Cruz Biotechnology (SCBT) CRISPR for AMOTL1
- GenScript: Design CRISPR guide RNA sequences for AMOTL1
miRNA Products
- Search ViGene Biosciences for AMOTL1
Inhibitory RNA Products
- Origene shRNA, siRNA, and RNAi products in human, mouse, rat for AMOTL1
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-
ViGene Biosciences ready-to-package AAV shRNAs for AMOTL1 gene
Clone Products
-
OriGene ORF clones in human for AMOTL1
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- VectorBuilder custom plasmid, inducible vectors for AMOTL1
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for AMOTL1
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Flow Cytometry Products
Expression for AMOTL1 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Lung (Respiratory System)
- Basal Cells Trachea
- Basal Cells Respiratory Bronchioles
-
Epithelial Cells
- Basal Cells Trachea
- Basal Cells Respiratory Bronchioles
-
Blood (Hematopoietic System)
- Hematopoietic Stem Cells Hematopoietic Bone Marrow
-
Placenta (Extraembryonic Tissues)
mRNA differential expression in normal tissues according to GTEx for AMOTL1 Gene
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for AMOTL1 Gene
NURSA nuclear receptor signaling pathways regulating expression of AMOTL1 Gene:
AMOTL1SOURCE GeneReport for Unigene cluster for AMOTL1 Gene:
Hs.503594Evidence on tissue expression from TISSUES for AMOTL1 Gene
- Nervous system(4.7)
- Muscle(4.4)
- Liver(4.2)
- Skin(4.2)
- Spleen(4.2)
- Heart(2.1)
Primer Products
-
OriGene qPCR primer pairs and template standards for AMOTL1
-
OriGene qPCR primer pairs for AMOTL1
No data available for Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for AMOTL1 Gene
Orthologs for AMOTL1 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | AMOTL1 34 35 |
|
||
| dog (Canis familiaris) |
Mammalia | AMOTL1 34 35 |
|
||
| cow (Bos Taurus) |
Mammalia | AMOTL1 34 35 |
|
||
| mouse (Mus musculus) |
Mammalia | Amotl1 34 16 35 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Amotl1 34 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | AMOTL1 35 |
|
OneToOne | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | -- 35 |
|
ManyToMany | |
| chicken (Gallus gallus) |
Aves | -- 35 |
|
ManyToMany | |
| AMOTL1 34 |
|
||||
| lizard (Anolis carolinensis) |
Reptilia | -- 35 |
|
ManyToMany | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | amotl1 34 |
|
||
| Str.10885 34 |
|
||||
| African clawed frog (Xenopus laevis) |
Amphibia | Xl.15676 34 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | CABZ01086041.1 35 |
|
ManyToMany | |
| worm (Caenorhabditis elegans) |
Secernentea | F59C12.3 35 |
|
OneToMany |
- Species where no ortholog for AMOTL1 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
Paralogs for AMOTL1 Gene
(2) SIMAP similar genes for AMOTL1 Gene using alignment to 3 proteins:
Variants for AMOTL1 Gene
| SNP ID | Clin | Chr 11 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs1000000062 | -- | 94,706,546(+) | TCACT(G/T)CTGTT | intron-variant, utr-variant-5-prime | |
| rs1000008670 | -- | 94,749,901(+) | CTGTT(G/T)CAGAA | intron-variant, nc-transcript-variant | |
| rs1000010273 | -- | 94,872,080(+) | GTATA(C/T)ACAGT | utr-variant-3-prime | |
| rs1000019012 | -- | 94,748,280(+) | AAGGT(A/G)ACTGT | intron-variant | |
| rs1000044312 | -- | 94,793,086(+) | CACAC(A/G)TATAT | intron-variant, upstream-variant-2KB |
Relevant External Links for AMOTL1 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- AMOTL1
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for AMOTL1 Gene
Disorders for AMOTL1 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| splenic marginal zone lymphoma |
|
|
Relevant External Links for AMOTL1
No data available for UniProtKB/Swiss-Prot and Genatlas for AMOTL1 Gene
Publications for AMOTL1 Gene
- Angiomotin belongs to a novel protein family with conserved coiled- coil and PDZ binding domains. (PMID: 12406577) Bratt A. … Holmgren L. (Gene 2002) 3 4 22 64
- Human angiomotin-like 1 associates with an angiomotin protein complex through its coiled-coil domain and induces the remodeling of the actin cytoskeleton. (PMID: 19565639) GagnAc V. … Fernandes M.J. (Cell Motil. Cytoskeleton 2009) 3 22 64
- Conduct disorder and ADHD: evaluation of conduct problems as a categorical and quantitative trait in the international multicentre ADHD genetics study. (PMID: 18951430) Anney R.J. … Gill M. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2008) 3 46 64
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
- JEAP, a novel component of tight junctions in exocrine cells. (PMID: 11733531) Nishimura M. … Takai Y. (J. Biol. Chem. 2002) 2 3 64
Products for AMOTL1 Gene
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- antibodies-online Antibodies for AMOTL1: See all 34
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- Search antibodies-online for proteins
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- GeneTex AMOTL1 antibody for AMOTL1
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- ViGene Biosciences adenoviral particle packaged cDNA for AMOTL1 gene
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- Horizon Cell Lines for AMOTL1
- Cyagen custom Knockout/knockin (KOKI) mouse models for AMOTL1
- VectorBuilder custom plasmid, inducible vectors for AMOTL1
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for AMOTL1
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Sources for AMOTL1 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) RNAdb
- (29) ASD
- (30) ECgene
- (31) GeneAnnot
- (32) CGAP SAGE
- (33) SOURCE
- (34) HomoloGene
- (35) PanEnsembl
- (36) euGenes
- (37) SGD
- (38) FlyBase
- (39) WormBase
- (40) Pseudogene
- (41) DGV
- (42) dbSNP
- (43) GenAtlas
- (44) GeneTests
- (45) HGMD
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