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Aliases for AMOT Gene

Aliases for AMOT Gene

  • Angiomotin 2 3
  • KIAA1071 4 6

External Ids for AMOT Gene

Previous GeneCards Identifiers for AMOT Gene

  • GC0XM107187
  • GC0XM109089
  • GC0XM110042
  • GC0XM110781
  • GC0XM111823
  • GC0XM112017

Summaries for AMOT Gene

Entrez Gene Summary for AMOT Gene

  • This gene belongs to the motin family of angiostatin binding proteins characterized by conserved coiled-coil domains and C-terminal PDZ binding motifs. The encoded protein is expressed predominantly in endothelial cells of capillaries as well as larger vessels of the placenta where it may mediate the inhibitory effect of angiostatin on tube formation and the migration of endothelial cells toward growth factors during the formation of new blood vessels. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]

GeneCards Summary for AMOT Gene

AMOT (Angiomotin) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Hippo signaling pathway. GO annotations related to this gene include receptor activity and angiostatin binding. An important paralog of this gene is AMOTL1.

UniProtKB/Swiss-Prot for AMOT Gene

  • Plays a central role in tight junction maintenance via the complex formed with ARHGAP17, which acts by regulating the uptake of polarity proteins at tight junctions. Appears to regulate endothelial cell migration and tube formation. May also play a role in the assembly of endothelial cell-cell junctions.

Gene Wiki entry for AMOT Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for AMOT Gene

Genomics for AMOT Gene

Regulatory Elements for AMOT Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for AMOT Gene

Start:
112,774,503 bp from pter
End:
112,840,908 bp from pter
Size:
66,406 bases
Orientation:
Minus strand

Genomic View for AMOT Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for AMOT Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for AMOT Gene

Proteins for AMOT Gene

  • Protein details for AMOT Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q4VCS5-AMOT_HUMAN
    Recommended name:
    Angiomotin
    Protein Accession:
    Q4VCS5
    Secondary Accessions:
    • Q504X5
    • Q9HD27
    • Q9UPT1

    Protein attributes for AMOT Gene

    Size:
    1084 amino acids
    Molecular mass:
    118085 Da
    Quaternary structure:
    • Component of a complex whose core is composed of ARHGAP17, AMOT, MPP5/PALS1, INADL/PATJ and PARD3/PAR3. Interacts with MAGI1. Isoform 1 interacts with angiostatin.
    Miscellaneous:
    • Motus means motility in Latin
    SequenceCaution:
    • Sequence=AAH94712.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305};

    Alternative splice isoforms for AMOT Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for AMOT Gene

Proteomics data for AMOT Gene at MOPED

Post-translational modifications for AMOT Gene

  • Polyubiquitinated by NEDD4, NEDD4L and ITCH, leading to proteasomal degradation.
  • Ubiquitination at Lys94, Lys113, and Lys219
  • Modification sites at PhosphoSitePlus

Other Protein References for AMOT Gene

Antibody Products

No data available for DME Specific Peptides for AMOT Gene

Domains for AMOT Gene

Protein Domains for AMOT Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for AMOT Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q4VCS5

UniProtKB/Swiss-Prot:

AMOT_HUMAN :
  • Q4VCS5
Domain:
  • The coiled coil domain interacts directly with the BAR domain of ARHGAP17.
  • The angiostatin binding domain (871-1005) allows the binding to angiostatin.
Family:
  • Belongs to the angiomotin family.
genes like me logo Genes that share domains with AMOT: view

No data available for Gene Families for AMOT Gene

Function for AMOT Gene

Molecular function for AMOT Gene

UniProtKB/Swiss-Prot Function:
Plays a central role in tight junction maintenance via the complex formed with ARHGAP17, which acts by regulating the uptake of polarity proteins at tight junctions. Appears to regulate endothelial cell migration and tube formation. May also play a role in the assembly of endothelial cell-cell junctions.

Gene Ontology (GO) - Molecular Function for AMOT Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004872 receptor activity IDA 11257124
GO:0005515 protein binding IPI 11257124
GO:0043532 angiostatin binding IDA 11257124
genes like me logo Genes that share ontologies with AMOT: view
genes like me logo Genes that share phenotypes with AMOT: view

Animal Models for AMOT Gene

MGI Knock Outs for AMOT:

miRNA for AMOT Gene

miRTarBase miRNAs that target AMOT

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for AMOT

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for AMOT Gene

Localization for AMOT Gene

Subcellular locations from UniProtKB/Swiss-Prot for AMOT Gene

Cell junction, tight junction. Note=Localized on the cell surface. May act as a transmembrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for AMOT Gene COMPARTMENTS Subcellular localization image for AMOT gene
Compartment Confidence
cytoskeleton 5
plasma membrane 5
cytosol 4
nucleus 2
extracellular 1
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for AMOT Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001725 stress fiber IDA 16043488
GO:0001726 ruffle IDA 11257124
GO:0005737 cytoplasm IDA 16043488
GO:0005829 cytosol TAS --
GO:0005884 actin filament IDA 11257124
genes like me logo Genes that share ontologies with AMOT: view

Pathways for AMOT Gene

genes like me logo Genes that share pathways with AMOT: view

Pathways by source for AMOT Gene

2 Reactome pathways for AMOT Gene
1 KEGG pathway for AMOT Gene

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for AMOT Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001570 vasculogenesis IEA --
GO:0001701 in utero embryonic development IEA --
GO:0001702 gastrulation with mouth forming second IEA --
GO:0003365 establishment of cell polarity involved in ameboidal cell migration IEA --
GO:0006935 chemotaxis IEA --
genes like me logo Genes that share ontologies with AMOT: view

Transcripts for AMOT Gene

Unigene Clusters for AMOT Gene

Angiomotin:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for AMOT

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for AMOT Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4a · 4b · 4c ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9a · 9b ^ 10a · 10b ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16
SP1:
SP2:
SP3:
SP4:
SP5: - - - - - -
SP6:
SP7: -
SP8:

Relevant External Links for AMOT Gene

GeneLoc Exon Structure for
AMOT
ECgene alternative splicing isoforms for
AMOT

Expression for AMOT Gene

mRNA expression in normal human tissues for AMOT Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for AMOT Gene

This gene is overexpressed in Muscle - Skeletal (4.4).

Protein differential expression in normal tissues for AMOT Gene

This gene is overexpressed in Bone marrow mesenchymal stem cell (45.4) and Blymphocyte (6.3).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for AMOT Gene

SOURCE GeneReport for Unigene cluster for AMOT Gene Hs.528051

mRNA Expression by UniProt/SwissProt for AMOT Gene

Q4VCS5-AMOT_HUMAN
Tissue specificity: Expressed in placenta and skeletal muscle. Found in the endothelial cells of capillaries as well as larger vessels of the placenta.
genes like me logo Genes that share expressions with AMOT: view

In Situ Assay Products

No data available for Expression partners for AMOT Gene

Orthologs for AMOT Gene

This gene was present in the common ancestor of animals.

Orthologs for AMOT Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia AMOT 35
  • 92.46 (n)
  • 96.02 (a)
AMOT 36
  • 93 (a)
OneToOne
dog
(Canis familiaris)
Mammalia AMOT 35
  • 91.15 (n)
  • 95.31 (a)
AMOT 36
  • 90 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Amot 35
  • 87.56 (n)
  • 92.82 (a)
Amot 16
Amot 36
  • 81 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia AMOT 35
  • 99.55 (n)
  • 99.89 (a)
AMOT 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Amot 35
  • 87.51 (n)
  • 92.4 (a)
oppossum
(Monodelphis domestica)
Mammalia AMOT 36
  • 69 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia AMOT 36
  • 66 (a)
OneToOne
chicken
(Gallus gallus)
Aves AMOT 35
  • 75.61 (n)
  • 79.8 (a)
AMOT 36
  • 78 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia AMOT 36
  • 72 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia amot 35
  • 68.94 (n)
  • 72.71 (a)
zebrafish
(Danio rerio)
Actinopterygii amot 35
  • 64.53 (n)
  • 66.36 (a)
amot 36
  • 57 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea F59C12.3 36
  • 20 (a)
OneToMany
Species with no ortholog for AMOT:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for AMOT Gene

ENSEMBL:
Gene Tree for AMOT (if available)
TreeFam:
Gene Tree for AMOT (if available)

Paralogs for AMOT Gene

Paralogs for AMOT Gene

Selected SIMAP similar genes for AMOT Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with AMOT: view

Variants for AMOT Gene

Sequence variations from dbSNP and Humsavar for AMOT Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type MAF
rs583430 -- 112,777,464(-) ATAGC(A/T)TGAGA utr-variant-3-prime
rs587424 -- 112,827,126(+) tgttg(A/G)gatta intron-variant, upstream-variant-2KB
rs589150 -- 112,797,309(-) TGGCT(A/G)TGAAC intron-variant
rs591816 -- 112,830,142(-) GTGCT(G/T)GGATT intron-variant
rs595613 -- 112,841,206(+) CAACA(G/T)CGCGG upstream-variant-2KB

Relevant External Links for AMOT Gene

HapMap Linkage Disequilibrium report
AMOT
Locus Specific Mutation Databases (LSDB)
AMOT

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for AMOT Gene

Disorders for AMOT Gene

(3) Novoseek inferred disease relationships for AMOT Gene

Disease -log(P) Hits PubMed IDs
breast cancer 19.3 3
metastasis 2.24 1
tumors 0 1

Relevant External Links for AMOT

Genetic Association Database (GAD)
AMOT
Human Genome Epidemiology (HuGE) Navigator
AMOT
genes like me logo Genes that share disorders with AMOT: view

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES and Genatlas for AMOT Gene

Publications for AMOT Gene

  1. Angiomotin. An angiostatin binding protein that regulates endothelial cell migration and tube formation. (PMID: 11257124) Troyanovsky B. … Holmgren L. (J. Cell Biol. 2001) 2 3 4 23
  2. Angiomotin belongs to a novel protein family with conserved coiled- coil and PDZ binding domains. (PMID: 12406577) Bratt A. … Holmgren L. (Gene 2002) 2 3 23
  3. A Rich1/Amot complex regulates the Cdc42 GTPase and apical-polarity proteins in epithelial cells. (PMID: 16678097) Wells C.D. … Pawson T. (Cell 2006) 3 4 23
  4. Angiomotin regulates endothelial cell-cell junctions and cell motility. (PMID: 16043488) Bratt A. … Holmgren L. (J. Biol. Chem. 2005) 2 3 4
  5. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey S.D. … Anand S. (Diabetes Care 2010) 3 48

Products for AMOT Gene

  • Addgene plasmids for AMOT

Sources for AMOT Gene

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