AMOT Gene

Aliases
for AMOT gene

Previous GC identifers: GC0XM107187 GC0XM109089 GC0XM110042 GC0XM110781 GC0XM111823

Summaries
for AMOT gene

Genomic Views
for AMOT gene

RefSeq DNA sequence:

NC_000023.10  NC_018934.1  NT_011651.17  

SwitchGear Promoter luciferase reporter plasmid: AMOT promoter sequence

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat AMOT

AMOT Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)


GeneLoc information about chromosome X         GeneLoc Exon Structure

GeneLoc location for GC0XM112017:  view genomic region     (about GC identifiers)

Proteins
for AMOT gene

Explore the universe of human proteins at neXtProt for AMOT: NX_Q4VCS5

Post-translational modifications:

	Browse Purified and Recombinant Proteins at EMD Millipore
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	OriGene Purified Protein: AMOT OriGene Protein Over-expression Lysate: AMOT OriGene Custom Protein Services for AMOT
	GenScript Custom Purified and Recombinant Proteins Services for AMOT
	Novus Biologicals AMOT Proteins Novus Biologicals AMOT Lysates
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for AMOT

Gene Ontology (GO): 5/13 cellular component terms (GO ID links to tree view) (see all 13):    About this table

	Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Browse R&D Systems for Antibodies
	Browse OriGene Antibodies OriGene Custom Antibody Services for AMOT
	GenScript Custom Superior Antibodies Services for AMOT
	Novus Biologicals AMOT Antibodies
	Search for Antibodies for AMOT at Abcam
	Uscn Antibodies for AMOT
	Search ThermoFisher Antibodies for AMOT

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for AMOT
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for AMOT

Protein Domains /
Families
for AMOT gene

ProtoNet protein and cluster: Q4VCS5

Function
for AMOT gene

miRNA Products:		OriGene 3'-UTR Clone (see all 2): AMOT Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat AMOT
		8/97 QIAGEN miScript miRNA Assays for microRNAs that regulate AMOT (see all 97):
		hsa-miR-124* hsa-miR-3938 hsa-miR-15a hsa-miR-3074-3p hsa-miR-10b* hsa-miR-1273d hsa-miR-1244 hsa-miR-629*
		SwitchGear 3'UTR luciferase reporter plasmid: AMOT 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for AMOT (see all 4) OriGene shRNA RFP: AMOT OriGene siRNA: AMOT
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat AMOT

Gene Editing Products:

DNA2.0 Custom Protein Engineering Service for AMOT

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for AMOT (see all 4) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for AMOT (see all 2) OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: AMOT (NM_016201)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for AMOT
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat AMOT

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for AMOT
		Search LifeMap BioReagents cell lines for AMOT

In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for AMOT

Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

(inferred from 1 allele) (MGI details for Amot)

Pathways & Interactions
for AMOT gene

	Super-pathway	contained gene-specific pathways
1	Signaling by Hippo	Signaling by Hippo 1.00
2	Signaling by GPCR	Signal Transduction 0.56

2        Reactome Pathways for AMOT

	Signaling by Hippo
	Signal Transduction

Gene Ontology (GO): 5/21 biological process terms (GO ID links to tree view) (see all 21):    About this table

Drugs & Compounds
for AMOT gene

Transcripts
for AMOT gene

Expression
for AMOT gene

AMOT expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TGTTTGTAAA

2 LifeMap In Vivo Development Anatomical Compartments/Cells
	Tissue Anatomical Compartment Cell			Category (developmental path)
	HypoblastExtraembryonic Visceral EndodermAnterior Visceral Endoderm Cells			Extraembryonic Tissues, Yolk Sac
	HypoblastExtraembryonic Visceral EndodermDistal Visceral Endoderm Cells			Extraembryonic Tissues, Yolk Sac
Expression: Positive    Negative     Selective marker Experimental details: Curated     Microarrays     In-situ hybridization
Stem Cell Differentiation: 6 LifeMap Cells
	Name			Category
	PureStem™ myogenic progenitor Z11 (Embryonic Progenitor Cell)			Heart, Myocardium, Smooth Muscle
	PureStem™ progenitor SM22 (Embryonic Progenitor Cell)
	PureStem™ progenitor W10 (Embryonic Progenitor Cell)
	N2/LSB/S/F8/CHIR-induced cells (Generation of midbra...)
	Pancreatic endoderm/endocrine precursor-like cells (A scalable, suspensi...)
	DKK1-induced cells (Derivation of cardio...)

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for AMOT Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT2 qPCR Primer Assay in human, mouse, rat AMOT
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat AMOT
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat AMOT

In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for AMOT

Orthologs
for AMOT gene

Paralogs
for AMOT gene

Paralogs for AMOT gene

AMOTL2²  AMOTL1²  

2 SIMAP similar genes for AMOT using alignment to 4 protein entries:     AMOT_HUMAN (see all proteins):

AMOTL1    AMOTL2

AMOT for paralogs           About GeneDecksing

Genomic Variants
for AMOT gene

10/839 NCBI SNPs in AMOT are shown (see all 839)     About this table

Genomic Data					Transcription Related Data				Allele Frequencies
SNP ID	Valid	Clinical significance	Chr X pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	--	--	--	-1st2nd3rd	--	--	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd
rs1846052251,2		--	112017758(+)	AACAAC/GGGTAC	2	--	ds5001		0	--	--	--	--
rs1882501671,2		--	112017779(+)	TCAAGA/GGGCCT	2	--	ds5001		0	--	--	--	--
rs1807276601,2		--	112017823(+)	TTTGGA/GTGGCC	2	--	ds5001		0	--	--	--	--
rs1863064761,2		--	112017919(+)	GCATGC/TGGCCT	2	--	ds5001		0	--	--	--	--
rs1893052231,2		--	112018070(+)	CCTCTC/GTCGGG	2	--	ds5001		0	--	--	--	--
rs1821337521,2		--	112018199(+)	TTGATC/TACAGA	2	--	ut31		0	--	--	--	--
rs1999958211,2		--	112018377(+)	AAAAT-/AAAC           AAACT	2	--	ut31		0	--	--	--	--
rs1866774211,2		--	112018546(+)	ATGCAC/TATAAG	2	--	ut31		0	--	--	--	--
rs1915335901,2		--	112018900(+)	CTCAAA/GCTACT	2	--	ut31		0	--	--	--	--
rs1431724171,2		--	112018906(+)	CTACTG/TTTTAT	2	--	ut31		0	--	--	--	--

HapMap Linkage Disequilibrium report for AMOT (112017731 - 112084043 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
      Database of Genomic Variants (DGV) variations for AMOT: --
Locus Specific Mutation Databases (LSDB): AMOT

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing AMOT

DNA2.0 Custom Variant and Variant Library Synthesis for AMOT

Disorders / Diseases
for AMOT gene

2 diseases for AMOT

3 Novoseek disease relationships for AMOT gene    About this table

Publications
for AMOT gene

PubMed articles for AMOT gene, integrated from 9 sources (see all 41): (articles sorted by number of sources associating them with AMOT)

Utopia: connect your pdf to the dynamic world of online information

1. Angiomotin. An angiostatin binding protein that regulates endothelial cell migration and tube formation. (PubMed id 11257124)^{1, 2, 3, 9} Troyanovsky B.... Holmgren L. (2001)
2. Angiomotin regulates endothelial cell-cell junctions and cell motility. (PubMed id 16043488)^{1, 2, 3} Bratt A....Holmgren L. (2005)
3. Angiomotin belongs to a novel protein family with conserved coiled- coil and PDZ binding domains. (PubMed id 12406577)^{1, 3, 9} Bratt A.... Holmgren L. (2002)
4. A Rich1/Amot complex regulates the Cdc42 GTPase and apical-polarity proteins in epithelial cells. (PubMed id 16678097)^{1, 2, 9} Wells C.D.... Pawson T. (2006)
5. The Nedd4-like ubiquitin E3 ligases target angiomotin/ p130 to ubiquitin-dependent degradation. (PubMed id 22385262)^{1, 2} Wang C....Yu L. (2012)
6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
7. Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones. (PubMed id 12168954)^{1, 2} Nakajima D.... Nagase T. (2002)
8. Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10470851)^{1, 2} Kikuno R....Ohara O. (1999)
9. p130-angiomotin associates to actin and controls endothelial cell shape. (PubMed id 16640563)^{1, 9} Ernkvist M....Holmgren L. (2006)
10. A DNA vaccine targeting angiomotin inhibits angiogenesis and suppresses tumor growth. (PubMed id 16754857)^{1, 9} Holmgren L....Kiessling R. (2006)

External Searches for AMOT gene

Genome Databases showing AMOT gene

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Specialized Databases showing AMOT gene

Products
for AMOT gene