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AMOT Gene

protein-coding   GIFtS: 58
GCID: GC0XM112017

Angiomotin

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
angiomotin1 2
KIAA10713 5
Angiomotin P130 Isoform2
Angiomotin P80 Isoform2

External Ids:    HGNC: 178101   Entrez Gene: 1547962   Ensembl: ENSG000001260167   OMIM: 3004105   UniProtKB: Q4VCS53   

Export aliases for AMOT gene to outside databases

Previous GC identifers: GC0XM107187 GC0XM109089 GC0XM110042 GC0XM110781 GC0XM111823


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for AMOT Gene:
This gene belongs to the motin family of angiostatin binding proteins characterized by conserved coiled-coil
domains and C-terminal PDZ binding motifs. The encoded protein is expressed predominantly in endothelial cells of
capillaries as well as larger vessels of the placenta where it may mediate the inhibitory effect of angiostatin
on tube formation and the migration of endothelial cells toward growth factors during the formation of new blood
vessels. Alternative splicing results in multiple transcript variants encoding different isoforms. (provided by
RefSeq, Jul 2008)

GeneCards Summary for AMOT Gene:
AMOT (angiomotin) is a protein-coding gene. GO annotations related to this gene include angiostatin binding and receptor activity. An important paralog of this gene is AMOTL2.

UniProtKB/Swiss-Prot: AMOT_HUMAN, Q4VCS5
Function: Plays a central role in tight junction maintenance via the complex formed with ARHGAP17, which acts by
regulating the uptake of polarity proteins at tight junctions. Appears to regulate endothelial cell migration and
tube formation. May also play a role in the assembly of endothelial cell-cell junctions

Gene Wiki entry for AMOT Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000023.10  NT_011651.18  NC_018934.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the AMOT gene promoter:
         E2F-4   E2F-3a   E2F-5   FOXD3   E2F-2   E2F   E2F-1   FOXO4   Sox9   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidAMOT promoter sequence
   Search Chromatin IP Primers for AMOT

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat AMOT


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: Xq23   Ensembl cytogenetic band:  Xq23   HGNC cytogenetic band: Xq23

AMOT Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
AMOT gene location

GeneLoc information about chromosome X         GeneLoc Exon Structure

GeneLoc location for GC0XM112017:  view genomic region     (about GC identifiers)

Start:
112,017,731 bp from pter      End:
112,084,043 bp from pter
Size:
66,313 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: AMOT_HUMAN, Q4VCS5 (See protein sequence)
Recommended Name: Angiomotin  
Size: 1084 amino acids; 118085 Da
Subunit: Component of a complex whose core is composed of ARHGAP17, AMOT, MPP5/PALS1, INADL/PATJ and PARD3/PAR3.
Interacts with MAGI1. Isoform 1 interacts with angiostatin
Miscellaneous: 'Motus' means 'motility' in Latin
Sequence caution: Sequence=AAH94712.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential
poly-A sequence;
Secondary accessions: Q504X5 Q9HD27 Q9UPT1
Alternative splicing: 2 isoforms:  Q4VCS5-1   Q4VCS5-2   

Explore the universe of human proteins at neXtProt for AMOT: NX_Q4VCS5

Explore proteomics data for AMOT at MOPED

Post-translational modifications: 

  • Polyubiquitinated by NEDD4, NEDD4L and ITCH, leading to proteasomal degradation1
  • Ubiquitination2 at Lys94, Lys113, Lys219
  • Modification sites at PhosphoSitePlus

  • See AMOT Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001106962.1  NP_573572.1  

    ENSEMBL proteins: 
     ENSP00000305557   ENSP00000361030   ENSP00000429013   ENSP00000361026   ENSP00000361027  

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    Novus Biologicals AMOT Proteins
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    Cloud-Clone Corp. Proteins for AMOT

     
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    antibodies-online proteins for AMOT (4 products) 

     
    antibodies-online peptides for AMOT

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    antibodies-online kits for AMOT (6 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    2 InterPro protein domains:
     IPR009114 Angiomotin
     IPR024646 Angiomotin_C

    Graphical View of Domain Structure for InterPro Entry Q4VCS5

    ProtoNet protein and cluster: Q4VCS5

    UniProtKB/Swiss-Prot: AMOT_HUMAN, Q4VCS5
    Domain: The coiled coil domain interacts directly with the BAR domain of ARHGAP17
    Domain: The angiostatin binding domain (871-1005) allows the binding to angiostatin
    Similarity: Belongs to the angiomotin family


    Find genes that share domains with AMOT           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: AMOT_HUMAN, Q4VCS5
    Function: Plays a central role in tight junction maintenance via the complex formed with ARHGAP17, which acts by
    regulating the uptake of polarity proteins at tight junctions. Appears to regulate endothelial cell migration and
    tube formation. May also play a role in the assembly of endothelial cell-cell junctions

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004872receptor activity IDA11257124
    GO:0005515protein binding IPI11257124
    GO:0043532angiostatin binding IDA11257124
         
    Find genes that share ontologies with AMOT           About GenesLikeMe


    Phenotypes:
         6 MGI mutant phenotypes (inferred from 1 allele(MGI details for Amot):
     cardiovascular system  cellular  embryogenesis  growth/size/body  mortality/aging 
     nervous system 

    Find genes that share phenotypes with AMOT           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Amottm1Bhr for AMOT

       genOway: Develop your customized and physiologically relevant rodent model for AMOT

    miRNA
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    Block miRNA regulation of human, mouse, rat AMOT using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate AMOT (see all 97):
    hsa-miR-124* hsa-miR-3938 hsa-miR-15a hsa-miR-3074-3p hsa-miR-10b* hsa-miR-1273d hsa-miR-1244 hsa-miR-629*
    SwitchGear 3'UTR luciferase reporter plasmidAMOT 3' UTR sequence
    Inhib. RNA
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    Addgene plasmids for AMOT 

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for AMOT


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    AMOT_HUMAN, Q4VCS5: Cell junction, tight junction. Note=Localized on the cell surface. May act as a
    transmembrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytoskeleton5
    plasma membrane5
    cytosol4
    nucleus2
    extracellular1
    mitochondrion1
    peroxisome1

    Gene Ontology (GO): Selected cellular component terms (see all 13):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001725stress fiber IDA16043488
    GO:0001726ruffle IDA11257124
    GO:0005737cytoplasm IDA16043488
    GO:0005829cytosol TAS--
    GO:0005884actin filament IDA11257124

    Find genes that share ontologies with AMOT           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for AMOT About    
    See pathways by source

    SuperPathContained pathways About
    1Signaling by GPCR
    Signal Transduction0.58
    2Signaling by Hippo
    Signaling by Hippo
    3Hippo signaling pathway
    Hippo signaling pathway


    Find genes that share SuperPaths with AMOT           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    1 Kegg Pathway  (Kegg details for AMOT):
        Hippo signaling pathway

        Pathway & Disease-focused RT2 Profiler PCR Array including AMOT: 
              Angiogenic Growth Factors in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for AMOT

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for AMOT (Q4VCS51, 3 ENSP000003610274) via UniProtKB, MINT, STRING, and/or I2D (see all 87)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ARHGAP17Q68EM71, 3, ENSP000002899684EBI-3891843,EBI-1642807 I2D: score=2 STRING: ENSP00000289968
    NF2P352401, 3, ENSP000003446664EBI-2511319,EBI-1014472 I2D: score=2 STRING: ENSP00000344666
    LIN7CQ9NUP93, ENSP000002781934I2D: score=3 STRING: ENSP00000278193
    MPP5Q8N3R93, ENSP000002616814I2D: score=3 STRING: ENSP00000261681
    PRKAA2P546463, ENSP000003602904I2D: score=3 STRING: ENSP00000360290
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 21):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001570vasculogenesis IEA--
    GO:0001701in utero embryonic development IEA--
    GO:0001702gastrulation with mouth forming second IEA--
    GO:0003365establishment of cell polarity involved in ameboidal cell migration IEA--
    GO:0006935chemotaxis IEA--

    Find genes that share ontologies with AMOT           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for AMOT



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for AMOT gene (2 alternative transcripts): 
    NM_001113490.1  NM_133265.2  

    Unigene Cluster for AMOT:

    Angiomotin
    Hs.528051  [show with all ESTs]
    Unigene Representative Sequence: NM_001113490
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000304758(uc004eps.3) ENST00000371962(uc011mtc.1) ENST00000524145(uc004ept.1)
    ENST00000371958 ENST00000462114 ENST00000371959(uc004epr.3)
    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate AMOT (see all 97):
    hsa-miR-124* hsa-miR-3938 hsa-miR-15a hsa-miR-3074-3p hsa-miR-10b* hsa-miR-1273d hsa-miR-1244 hsa-miR-629*
    SwitchGear 3'UTR luciferase reporter plasmidAMOT 3' UTR sequence
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    Addgene plasmids for AMOT 
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      QuantiTect SYBR Green Assays in human, mouse, rat AMOT
      QuantiFast Probe-based Assays in human, mouse, rat AMOT

    Additional mRNA sequence: 

    AB028994.3 AF286598.1 AK024344.1 AK301573.1 AY987378.1 BC039408.1 BC050581.1 BC094712.1 
    BC130294.1 

    5 DOTS entries:

    DT.415344  DT.95086219  DT.121281127  DT.100760858  DT.95298478 

    Selected AceView cDNA sequences (see all 130):

    BP347810 AA812119 AL043714 BU677952 AL043713 AI379516 BC050581 BG171118 
    BU684377 AB028994 AA863467 AA912758 BX641261 AA142848 AJ346559 BU686496 
    AA424355 AI148665 AA496984 BM905357 AI972370 AA127722 CA438364 BP349217 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for AMOT (see all 8)    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4a · 4b · 4c ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9a · 9b ^ 10a · 10b ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16
    SP1:                                                                                                                                          
    SP2:                                                                                                                                          
    SP3:                                                                                                                                          
    SP4:                                                                                                                                          
    SP5:                    -     -     -     -     -     -                                                                                       


    ECgene alternative splicing isoforms for AMOT

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    AMOT expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGTTTGTAAA
    AMOT Expression
    About this image


    AMOT expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 10) fully expand
     
     Yolk Sac (Extraembryonic Tissues)    fully expand to see all 3 entries
             Definitive Hematopoietic Stem Cells Definitive Yolk Sac
     
     Limb (Muscoskeletal System)    fully expand to see all 2 entries
             Prechondrocytic Mesenchymal Cells Zeugopod
             Limb Bud
     
     Hypoblast (Extraembryonic Tissues)    fully expand to see all 2 entries
             Anterior Visceral Endoderm Cells Extraembryonic Visceral Endoderm
     
     Epiblast (Early Embryonic Tissues)    fully expand to see all 2 entries
             Epiblast Stem Cell line 5
     
     NULL (Uncategorized)
             DKK1-induced cells
    AMOT Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    AMOT Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.528051

    UniProtKB/Swiss-Prot: AMOT_HUMAN, Q4VCS5
    Tissue specificity: Expressed in placenta and skeletal muscle. Found in the endothelial cells of capillaries as
    well as larger vessels of the placenta

        Pathway & Disease-focused RT2 Profiler PCR Array including AMOT: 
              Angiogenic Growth Factors in human mouse rat

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for AMOT

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for AMOT gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Amot1 , 5 angiomotin1, 5 87.56(n)1
    92.82(a)1
      X (66.72 cM)5
    274941  NM_153319.21  NP_695231.21 
     1454464255 
    chicken
    (Gallus gallus)
    Aves AMOT1 angiomotin 75.61(n)
    79.8(a)
      422336  XM_004940799.1  XP_004940856.1 
    lizard
    (Anolis carolinensis)
    Reptilia AMOT6
    angiomotin
    72(a)
    1 ↔ 1
    GL343420.1(642829-688317)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia amot1 angiomotin 68.94(n)
    72.71(a)
      100144927  XM_002938787.2  XP_002938833.2 
    zebrafish
    (Danio rerio)
    Actinopterygii amot1 angiomotin 64.53(n)
    66.36(a)
      563421  XM_686779.6  XP_691871.6 
    worm
    (Caenorhabditis elegans)
    Secernentea F59C12.36
    Protein F59C12.3 (F59C12.3) mRNA, complete cds
    20(a)
    1 → many
    X(16603386-16609524) WBGene00019102


    ENSEMBL Gene Tree for AMOT (if available)
    TreeFam Gene Tree for AMOT (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for AMOT gene
    AMOTL22  AMOTL12  
    2 SIMAP similar genes for AMOT using alignment to 4 protein entries:     AMOT_HUMAN (see all proteins):
    AMOTL1    AMOTL2

    Find genes that share paralogs with AMOT           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for AMOT (see all 976)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr X posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
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    ----------
    rs1846052251,2
    --111997834(+) AACAAC/GGGTAC 2 -- ds50010--------
    rs1882501671,2
    --111997855(+) TCAAGA/GGGCCT 2 -- ds50010--------
    rs1807276601,2
    --111997899(+) TTTGGA/GTGGCC 2 -- ds50010--------
    rs1863064761,2
    --111997995(+) GCATGC/TGGCCT 2 -- ds50010--------
    rs1893052231,2
    --111998146(+) CCTCTC/GTCGGG 2 -- ds50010--------
    rs1821337521,2
    --111998275(+) TTGATC/TACAGA 2 -- ut310--------
    rs1130378611,2
    C--111998453(+) AAAAT-/AAAC  
            
    AAACT
    2 -- ut311Minor allele frequency- AAAC:0.00CSA 2
    rs1866774211,2
    --111998622(+) ATGCAC/TATAAG 2 -- ut310--------
    rs1915335901,2
    --111998976(+) CTCAAA/GCTACT 2 -- ut310--------
    rs1431724171,2
    --111998982(+) CTACTG/TTTTAT 2 -- ut310--------

    HapMap Linkage Disequilibrium report for AMOT (112017731 - 112084043 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for AMOT: --
    Locus Specific Mutation Databases (LSDB): AMOT

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing AMOT
    DNA2.0 Custom Variant and Variant Library Synthesis for AMOT

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 300410    OMIM disorders: --


    Find genes that share disorders with AMOT           About GenesLikeMe

    3 Novoseek inferred disease relationships for AMOT gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    breast cancer 19.3 3 16430777 (2), 16754857 (1)
    metastasis 2.24 1 16430777 (1)
    tumors 0 1 16754857 (1)

    Genetic Association Database (GAD): AMOT
    Human Genome Epidemiology (HuGE) Navigator: AMOT (3 documents)

    Export disorders for AMOT gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for AMOT gene, integrated from 10 sources (see all 58):
    (articles sorted by number of sources associating them with AMOT)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Angiomotin. An angiostatin binding protein that regulates endothelial cell migration and tube formation. (PubMed id 11257124)1, 2, 3, 9 Troyanovsky B.... Holmgren L. (J. Cell Biol. 2001)
    2. Angiomotin regulates endothelial cell-cell junctions and cell motility. (PubMed id 16043488)1, 2, 3 Bratt A....Holmgren L. (J. Biol. Chem. 2005)
    3. Angiomotin belongs to a novel protein family with conserved coiled- coil and PDZ binding domains. (PubMed id 12406577)1, 3, 9 Bratt A.... Holmgren L. (Gene 2002)
    4. A Rich1/Amot complex regulates the Cdc42 GTPase and apical-polarity proteins in epithelial cells. (PubMed id 16678097)1, 2, 9 Wells C.D.... Pawson T. (Cell 2006)
    5. The Nedd4-like ubiquitin E3 ligases target angiomotin/p130 to ubiquitin-dependent degradation. (PubMed id 22385262)1, 2 Wang C.... Yu L. (Biochem. J. 2012)
    6. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)
    7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    8. Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones. (PubMed id 12168954)1, 2 Nakajima D.... Nagase T. (DNA Res. 2002)
    9. Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10470851)1, 2 Kikuno R.... Ohara O. (DNA Res. 1999)
    10. p130-angiomotin associates to actin and controls endothelial cell shape. (PubMed id 16640563)1, 9 Ernkvist M....Holmgren L. (FEBS J. 2006)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

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    Entrez Gene: 154796 HGNC: 17810 AceView: AMOT Ensembl:ENSG00000126016 euGenes: HUgn154796
    ECgene: AMOT Kegg: 154796 H-InvDB: AMOT

    (According to HUGE)
    About This Section

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    HUGE: KIAA1071

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for AMOT Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for AMOT Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for AMOT gene:
    Search GeneIP for patents involving AMOT

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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