Aliases for AMN1 Gene
Aliases for AMN1 Gene
External Ids for AMN1 Gene
- HGNC: 27281
- Entrez Gene: 196394
- Ensembl: ENSG00000151743
- UniProtKB: Q8IY45
Previous GeneCards Identifiers for AMN1 Gene
- GC12M031716
- GC12M031824
- GC12M031576
Summaries for AMN1 Gene
GeneCards Summary for AMN1 Gene
AMN1 (Antagonist Of Mitotic Exit Network 1 Homolog) is a Protein Coding gene.
No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for AMN1 Gene
Genomics for AMN1 Gene
Regulatory Elements for AMN1 Gene
Enhancers for AMN1 Gene
- Elite enhancer and/or Elite enhancer-gene association
Download GeneHancer data dump
Enhancers around AMN1 on UCSC Golden Path with GeneCards custom track
Regulatory Element Products
Genomic Location for AMN1 Gene
- Chromosome:
- 12
- Start:
- 31,671,137 bp from pter
- End:
- 31,730,392 bp from pter
- Size:
- 59,256 bases
- Orientation:
- Minus strand
Genomic View for AMN1 Gene
Genes around AMN1 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 12p11.21 by Ensembl
- 12p11.21 by Entrez Gene
- 12p11.21 by HGNC
AMN1 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for AMN1 Gene
Proteins for AMN1 Gene
-
Protein details for AMN1 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q8IY45-AMN1_HUMAN
- Recommended name:
- Protein AMN1 homolog
- Protein Accession:
- Q8IY45
- B7Z7J3
- Q6NVU4
- Q86X98
Protein attributes for AMN1 Gene
- Size:
- 258 amino acids
- Molecular mass:
- 28408 Da
- Quaternary structure:
- No Data Available
- SequenceCaution:
-
- Sequence=AAH37897.3; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAH45831.2; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAH67906.1; Type=Erroneous initiation; Evidence={ECO:0000305};
Protein Expression for AMN1 Gene
Post-translational modifications for AMN1 Gene
Other Protein References for AMN1 Gene
Antibody Products
-
Custom Antibody ServicesOriGene Antibodies for AMN1
- Novus Biologicals Antibodies for AMN1
- Invitrogen Antibodies for AMN1
- GeneTex AMN1 antibody for AMN1
Protein Products
-
OriGene Purified Proteins for AMN1
- Search Origene for MassSpec and Protein Over-expression Lysates for AMN1
- Origene Custom Protein Services for AMN1
- Search GeneTex for Proteins for AMN1
Assay Products
No data available for DME Specific Peptides for AMN1 Gene
Domains & Families for AMN1 Gene
Protein Domains for AMN1 Gene
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for AMN1 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q8IY45- Family:
-
- Belongs to the AMN1 family.
No data available for Gene Families for AMN1 Gene
Function for AMN1 Gene
Phenotypes for AMN1 Gene
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for AMN1
-
-
ViGene Biosciences lentiviral particle packaged cDNA for AMN1 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for AMN1 gene
- Search ViGene Biosciences for AMN1
CRISPR Products
-
OriGene CRISPR knockouts for AMN1
-
Santa Cruz Biotechnology (SCBT) CRISPR for AMN1
- GenScript: Design CRISPR guide RNA sequences for AMN1
miRNA Products
- Search ViGene Biosciences for AMN1
Inhibitory RNA Products
- Origene shRNA, siRNA, and RNAi products in human, mouse, rat for AMN1
- Browse OriGene Inhibitory RNA Products For AMN1
-
ViGene Biosciences ready-to-package AAV shRNAs for AMN1 gene
Clone Products
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for AMN1
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for AMN1
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Cell Line Products
-
Horizon Cell Lines for AMN1
-
ViGene Biosciences adenoviral particle packaged cDNA for AMN1 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for AMN1 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for AMN1 gene
Flow Cytometry Products
No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for AMN1 Gene
Localization for AMN1 Gene
| Compartment | Confidence |
|---|---|
| extracellular | 2 |
| plasma membrane | 1 |
| mitochondrion | 1 |
| nucleus | 1 |
| cytosol | 1 |
| lysosome | 1 |
No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for AMN1 Gene
Pathways & Interactions for AMN1 Gene
No data available for Pathways by source and SIGNOR curated interactions for AMN1 Gene
Transcripts for AMN1 Gene
mRNA/cDNA for AMN1 Gene
- (8) REFSEQ mRNAs :
- (9) Additional mRNA sequences :
- (122) Selected AceView cDNA sequences:
- (12) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for AMN1 Gene
- Antagonist of mitotic exit network 1 homolog (S. cerevisiae):
- Representative Sequences:
CRISPR Products
-
OriGene CRISPR knockouts for AMN1
-
Santa Cruz Biotechnology (SCBT) CRISPR for AMN1
- GenScript: Design CRISPR guide RNA sequences for AMN1
miRNA Products
- Search ViGene Biosciences for AMN1
Inhibitory RNA Products
- Origene shRNA, siRNA, and RNAi products in human, mouse, rat for AMN1
- Browse OriGene Inhibitory RNA Products For AMN1
-
ViGene Biosciences ready-to-package AAV shRNAs for AMN1 gene
Clone Products
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for AMN1
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for AMN1
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Flow Cytometry Products
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | · | 1e | · | 1f | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8a | · | 8b | ^ | 9a | · | 9b | ^ | 10a | · | 10b | · | 10c | · | 10d | ^ | 11 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | ||||||||||||||||||||||||||||||||||||||||
| SP2: | - | - | - | - | |||||||||||||||||||||||||||||||||||||
| SP3: | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||
| SP4: | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||
| SP5: | - | - | |||||||||||||||||||||||||||||||||||||||
| SP6: | |||||||||||||||||||||||||||||||||||||||||
| SP7: | - | - | - |
Expression for AMN1 Gene
This gene is overexpressed in Testis (36.3) and Ovary (28.6).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for AMN1 Gene
- Elite partner
NURSA nuclear receptor signaling pathways regulating expression of AMN1 Gene:
AMN1SOURCE GeneReport for Unigene cluster for AMN1 Gene:
Hs.585084Evidence on tissue expression from TISSUES for AMN1 Gene
- Nervous system(3.9)
Primer Products
-
OriGene qPCR primer pairs for AMN1
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for AMN1 Gene
Orthologs for AMN1 Gene
This gene was present in the common ancestor of animals and fungi.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | AMN1 34 35 |
|
||
| dog (Canis familiaris) |
Mammalia | AMN1 34 35 |
|
||
| cow (Bos Taurus) |
Mammalia | AMN1 34 35 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Amn1 34 |
|
||
| mouse (Mus musculus) |
Mammalia | Amn1 34 16 35 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | AMN1 35 |
|
OneToOne | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | AMN1 35 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | AMN1 34 35 |
|
||
| lizard (Anolis carolinensis) |
Reptilia | AMN1 35 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | LOC100485350 34 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | amn1 34 35 |
|
||
| baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | AMN1 37 |
|
|
- Species where no ortholog for AMN1 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Paralogs for AMN1 Gene
(9) SIMAP similar genes for AMN1 Gene using alignment to 8 proteins:
No data available for Paralogs for AMN1 Gene
Variants for AMN1 Gene
| SNP ID | Clin | Chr 12 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs1000050426 | -- | 31,701,475(+) | TTTTT(G/T)GTAGA | intron-variant | |
| rs1000106667 | -- | 31,682,737(+) | TTGAG(A/C)TAACA | intron-variant | |
| rs1000161298 | -- | 31,689,503(+) | GAAAA(C/G)AGCTA | intron-variant | |
| rs1000201362 | -- | 31,696,167(+) | GGGAC(A/G)TGGAA | intron-variant | |
| rs1000209549 | -- | 31,682,528(+) | GGTGT(C/T)TCTGG | intron-variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv2422415 | CNV | duplication | 17116639 |
| esv2667845 | CNV | deletion | 23128226 |
| esv2760267 | CNV | gain+loss | 21179565 |
| esv3629053 | CNV | loss | 21293372 |
| nsv1050448 | CNV | gain | 25217958 |
| nsv473227 | CNV | novel sequence insertion | 20440878 |
| nsv558100 | CNV | gain | 21841781 |
| nsv558101 | CNV | gain | 21841781 |
| nsv662 | CNV | insertion | 18451855 |
Residual Variation Intolerance Score:
33.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
0.30;
6.73% of all genes are more intolerant (likely to be disease-causing)
Relevant External Links for AMN1 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- AMN1
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for AMN1 Gene
Disorders for AMN1 Gene
Relevant External Links for AMN1
- Atlas of Genetics and Cytogenetics in Oncology and Haematology:
- AMN1
No disorders were found for AMN1 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for AMN1 Gene
Publications for AMN1 Gene
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
- Interrogation of the platelet-derived growth factor receptor alpha locus and corneal astigmatism in Australians of Northern European ancestry: results of a genome-wide association study. (PMID: 23761726) Yazar S. … Hewitt A.W. (Mol. Vis. 2013) 3 64
- The finished DNA sequence of human chromosome 12. (PMID: 16541075) Scherer S.E. … Gibbs R.A. (Nature 2006) 4 64
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 4 64
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3 64
Products for AMN1 Gene
- Browse R&D Systems for Antibodies
- Browse R&D Systems for Human Recombinant Proteins
- Browse R&D Systems for biochemical assays
- Browse Primary Antibodies
- Browse Proteins and Enzymes
- Browse ELISAs
- Browse Activity Assays
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- Browse Cell Culture Products
- Browse Cell Selection and Detection Kits
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- Browse Immunoprecipitation Assays
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- Browse Proteome Profiler Antibody Arrays
- Browse Small Molecules
- Custom Antibody ServicesOriGene Antibodies for AMN1
- Browse OriGene ELISA Kits
- Custom Assay Services
- OriGene Purified Proteins for AMN1
- Search Origene for MassSpec and Protein Over-expression Lysates for AMN1
- Origene Custom Protein Services for AMN1
- Origene shRNA, siRNA, and RNAi products in human, mouse, rat for AMN1
- Browse OriGene Inhibitory RNA Products For AMN1
- OriGene qPCR primer pairs for AMN1
- OriGene CRISPR knockouts for AMN1
- OriGene ORF clones in human for AMN1
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For AMN1
- GenScript: Next-day shipping cDNA ORF clone for AMN1 in any vector
- GenScript Custom Purified and Recombinant Proteins Services for AMN1
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- GenScript: Design CRISPR guide RNA sequences for AMN1
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- CloneReady with Over 120,000 Genes
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- Gene Mutant Library, Variants up to 10^11
- Plasmid Preparation
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- Browse Sino Biological cDNA Clones
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- Sino Biological Antibodies
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- Sino Biological Cell Lysates
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- Sino Biological Transfection Reagents
- Novus Biologicals Antibodies for AMN1
- Novus Biologicals proteins and lysates for AMN1
- Novus Biologicals
- Novus Biologicals Tissue Microarrays
- ViGene Biosciences adenoviral particle packaged cDNA for AMN1 gene
- ViGene Biosciences lentiviral particle packaged cDNA for AMN1 gene
- ViGene Biosciences ready-to-package AAV shRNAs for AMN1 gene
- Search ViGene Biosciences for AMN1
- Horizon Cell Lines for AMN1
- Cyagen custom Knockout/knockin (KOKI) mouse models for AMN1
- VectorBuilder custom plasmid, inducible vectors for AMN1
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for AMN1
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Sources for AMN1 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) RNAdb
- (29) ASD
- (30) ECgene
- (31) GeneAnnot
- (32) CGAP SAGE
- (33) SOURCE
- (34) HomoloGene
- (35) PanEnsembl
- (36) euGenes
- (37) SGD
- (38) FlyBase
- (39) WormBase
- (40) Pseudogene
- (41) DGV
- (42) dbSNP
- (43) GenAtlas
- (44) GeneTests
- (45) HGMD
- (46) GAD
- (47) LSDB
- (48) BGMUT
- (49) HuGE
- (50) eBioscience
- (51) Atlas
- (52) Cell Signaling Technology
- (53) GenBank
- (54) H-invDB
- (55) HORDE
- (56) HUGE
- (57) IMGT
- (58) Leiden
- (59) MILLIPORE
- (60) miRBase
- (61) DME
- (62) NCBI
- (63) OriGene
- (64) PubMed
- (65) R&D Systems
- (66) TGDB
- (67) Tocris
- (68) Abcam
- (69) Novus
- (70) ProSpec
- (71) Sino Biological
- (72) GenScript
- (73) Qiagen
- (74) Cloud-Clone Corp.
- (75) Enzo Life Sciences
- (76) OCA
- (77) Proteopedia
- (78) MOPED
- (79) SPIRE
- (80) neXtProt
- (81) Reactome
- (82) GeneGo (Thomson Reuters)
- (83) fRNAdb
- (84) DISEASES
- (85) SIMAP
- (86) GenomeRNAi
- (87) LifeMap
- (88) miRTarBase
- (89) MalaCards
- (90) Invitrogen
- (91) BitterDB
- (92) Vector BioLabs
- (93) ESI-BIO
- (94) RefSeq
- (95) BioSystems
- (96) MaxQB
- (97) IUPHAR
- (98) BioGPS
- (99) Illumina
- (100) COMPARTMENTS
- (101) HOMER
- (102) PaxDb
- (103) ApexBio
- (104) Addgene
- (105) antibodies-online
- (106) CYP
- (107) NONCODE
- (108) SwitchGear Genomics
- (109) TreeFam
- (110) PathCards
- (111) GeneReviews
- (112) GeneTex
- (113) Taconic Biosciences
- (114) GTEx
- (115) ProteomicsDB
- (116) SCBT
- (117) DGIdb
- (118) ClinicalTrials
- (119) FDA Approved Drugs
- (120) RVIS
- (121) SIGNOR
- (122) diseasecard
- (123) NIH Rare Diseases
- (124) Orphanet
- (125) UMLS
- (126) GTR
- (127) Disease Ontology
- (128) Genetics Home Reference
- (129) MeSH
- (130) MedlinePlus
- (131) CDC
- (132) NINDS
- (133) NCBI Bookshelf
- (134) ClinVar
- (135) Gene Damage Index
- (136) ViGene Biosciences
- (137) HPO
- (138) UDN
- (139) VISTA
- (140) FANTOM5
- (141) ENCODE
- (142) ProSci
- (143) Horizon
- (144) NURSA
- (145) IID
- (146) Cyagen
- (147) VectorBuilder
- (148) SNPedia
- (149) BRCA Exchange
- (150) St John's Lab
- (151) CIViC
- (152) ProteoGenix
- (153) dbSUPER
- (154) TISSUES
- (155) Gene ORGANizer