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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

AMN1 Gene

protein-coding   GIFtS: 45
GCID: GC12M031824

Antagonist Of Mitotic Exit Network 1 Homolog (S. Cerevisiae)

  See related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Antagonist Of Mitotic Exit Network 1 Homolog (S. Cerevisiae)1 2
Protein AMN1 Homolog2

External Ids:    HGNC: 272811   Entrez Gene: 1963942   Ensembl: ENSG000001517437   UniProtKB: Q8IY453   
ORGUL members:         
NONCODE14:n406340      

Export aliases for AMN1 gene to outside databases

Previous GC identifers: GC12M031716 GC12M031576


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for AMN1 Gene: 
AMN1 (antagonist of mitotic exit network 1 homolog (S. cerevisiae)) is a protein-coding gene, and is affiliated with the lncRNA class. Diseases associated with AMN1 include adrenoleukodystrophy.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000012.11  NC_018923.2  NT_009714.17  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the AMN1 gene promoter:
         GR   Elk-1   GATA-3   Lmo2   Nkx5-1   Evi-1   GATA-1   GATA-2   Arnt   GR-alpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidAMN1 promoter sequence
   Search SABiosciences Chromatin IP Primers for AMN1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat AMN1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12p11.21   Ensembl cytogenetic band:  12p11.21   HGNC cytogenetic band: 12p11.21

AMN1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
AMN1 gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12M031824:  view genomic region     (about GC identifiers)

Start:
31,824,071 bp from pter      End:
31,882,108 bp from pter
Size:
58,038 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: AMN1_HUMAN, Q8IY45 (See protein sequence)
Recommended Name: Protein AMN1 homolog  
Size: 258 amino acids; 28408 Da
Sequence caution: Sequence=AAH37897.3; Type=Erroneous initiation; Sequence=AAH45831.2; Type=Erroneous initiation;
Sequence=AAH67906.1; Type=Erroneous initiation;
Secondary accessions: Q6NVU4 Q86X98

Explore the universe of human proteins at neXtProt for AMN1: NX_Q8IY45

Explore proteomics data for AMN1 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q8IY45

  • AMN1 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    AMN1 Protein Expression
    REFSEQ proteins (3 alternative transcripts): 
    NP_001106873.1  NP_001265340.1  NP_001265341.1  

    ENSEMBL proteins: 
     ENSP00000281471   ENSP00000441419   ENSP00000439171   ENSP00000440967   ENSP00000442272  
     ENSP00000438990   ENSP00000441846   ENSP00000439438   ENSP00000396145  

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    Novus Biologicals AMN1 Lysates
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    Browse Sino Biological Cell Lysates 
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    Cloud-Clone Corp. Proteins for AMN1 


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    Cloud-Clone Corp. ELISAs for AMN1 
    Cloud-Clone Corp. CLIAs for AMN1


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    1 InterPro protein domain:
     IPR026738 AMN1-like

    Graphical View of Domain Structure for InterPro Entry Q8IY45

    ProtoNet protein and cluster: Q8IY45

    UniProtKB/Swiss-Prot: AMN1_HUMAN, Q8IY45
    Similarity: Belongs to the AMN1 family


    AMN1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Phenotypes:
         2 GenomeRNAi human phenotypes for AMN1:
     Increased G1 DNA content  Increased number of mitotic ce 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for AMN1 
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    hsa-miR-3671 hsa-miR-3140-3p hsa-miR-3653 hsa-miR-3921 hsa-miR-511 hsa-miR-3142 hsa-miR-182 hsa-miR-466
    SwitchGear 3'UTR luciferase reporter plasmidAMN1 3' UTR sequence
    Inhib. RNA
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for AMN1

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for AMN1

    Search CenterWatch for drugs/clinical trials and news about AMN1

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for AMN1 gene (3 alternative transcripts): 
    NM_001113402.1  NM_001278411.1  NM_001278412.1  

    Unigene Cluster for AMN1:

    Antagonist of mitotic exit network 1 homolog (S. cerevisiae)
    Hs.585084  [show with all ESTs]
    Unigene Representative Sequence: NM_001113402
    12 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000281471(uc001rkq.4 uc001rko.4 uc010skc.2 uc009zjs.3)
    ENST00000537562 ENST00000541931 ENST00000536761 ENST00000542781(uc009zjt.1)
    ENST00000535408 ENST00000537960 ENST00000506446 ENST00000457428 ENST00000541541
    ENST00000422146 ENST00000509386
    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat AMN1
    8/12 QIAGEN miScript miRNA Assays for microRNAs that regulate AMN1 (see all 12):
    hsa-miR-3671 hsa-miR-3140-3p hsa-miR-3653 hsa-miR-3921 hsa-miR-511 hsa-miR-3142 hsa-miR-182 hsa-miR-466
    SwitchGear 3'UTR luciferase reporter plasmidAMN1 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for AMN1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat AMN1
    Clone
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    OriGene ORF clones in mouse, rat for AMN1
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    GenScript: all cDNA clones in your preferred vector: AMN1 (NM_001113402)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for AMN1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat AMN1
    Sirion Biotech Customized lentivirus for stable overexpression of AMN1 
                         Customized lentivirus expression plasmids for stable overexpression of AMN1 
    Primer
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    OriGene qSTAR qPCR primer pairs in human, mouse for AMN1
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat AMN1
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat AMN1

    Additional mRNA sequence: 

    AK123033.1 AK302112.1 AK311214.1 AK311249.1 AL833434.1 BC037897.2 BC045831.1 BC067906.1 
    NR_004854.1 

    8 DOTS entries:

    DT.307269  DT.100754535  DT.95172234  DT.40261427  DT.92423658  DT.100836897  DT.121186781  DT.97791119 

    24/122 AceView cDNA sequences (see all 122):

    BM756838 BE792595 N45121 BU629034 BM462699 BM713242 BC045831 CA867775 
    AK123033 BM799513 CR608460 CD675541 AV715011 CR598985 CR618732 AW079529 
    CA429807 BM756754 AA931787 BU193172 AA280156 AI471734 AA829949 N66589 

    GeneLoc Exon Structure

    5/7 Alternative Splicing Database (ASD) splice patterns (SP) for AMN1 (see all 7)    About this scheme

    ExUns: 1a · 1b · 1c · 1d · 1e · 1f ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9a · 9b ^ 10a · 10b · 10c · 10d ^ 11
    SP1:                                                              -                                                               
    SP2:                                      -     -     -           -                                                               
    SP3:                                      -     -     -     -     -                                                               
    SP4:                                -     -     -     -           -                                                               
    SP5:                                                  -           -                                                               


    ECgene alternative splicing isoforms for AMN1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    AMN1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AGCCAGTCTT
    AMN1 Expression
    About this image


    See AMN1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for AMN1

    SOURCE GeneReport for Unigene cluster: Hs.585084
        SABiosciences Custom PCR Arrays for AMN1
    Primer
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    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat AMN1
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for AMN1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals and fungi.

    Orthologs for AMN1 gene from 6/12 species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Amn11 , 5 antagonist of mitotic exit network 1 homolog (S. cerevisiae)5
    antagonist of mitotic exit network 11
    82.17(n)1
    76.36(a)1
      6 (78.81 cM)5
    2325661  NM_001113424.11  NP_001106895.11 
     1491571475 
    chicken
    (Gallus gallus)
    Aves AMN11 antagonist of mitotic exit network 1 homolog (S. cerevisiae) 71.75(n)
    69.88(a)
      418137  XM_416368.2  XP_416368.1 
    lizard
    (Anolis carolinensis)
    Reptilia AMN16
    Uncharacterized protein
    65(a)
    1 ↔ 1
    5(10629143-10652764)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia BX746347.12   -- 71.37(n)    BX746347.1 
    zebrafish
    (Danio rerio)
    Actinopterygii amn11 antagonist of mitotic exit network 1 homolog (S. cerevisiae) 55.56(n)
    47.56(a)
      751744  NM_001045454.1  NP_001038919.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes AMN1(YBR158W)4 Protein required for daughter cell separation, multiple more   --   2(556549-558198) 852455  NP_009716.1 


    ENSEMBL Gene Tree for AMN1 (if available)
    TreeFam Gene Tree for AMN1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for AMN1 gene
    13 SIMAP similar genes for AMN1 using alignment to 8 protein entries:     AMN1_HUMAN (see all proteins):
    PLA2G15    PACSIN2    DNAAF1    FAM138A    FAM138B    FAM138C
    FAM138F    FAM138D    EYS    APCDD1    OK/SW-cl.41    UTY
    FBXL2

    AMN1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1266 SNPs in AMN1 are shown (see all 1266)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 12 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1510732381,2
    C--31823659(+) CCTTTA/CTTTCT 2 -- int10--------
    rs73099161,2
    C,F,A,H--31823771(+) AAATAT/CTTTGT 2 -- int111Minor allele frequency- C:0.32NA WA CSA EA 376
    rs1881929861,2
    --31823782(+) CCTTAC/TGAAAT 2 -- int10--------
    rs1408199211,2
    C--31823952(+) AGCAAC/TATAAA 2 -- int10--------
    rs1806875721,2
    --31824037(+) GATGTC/TGAAAC 2 -- int10--------
    rs1497260601,2
    --31824066(+) GAAAAA/TGTGAT 2 -- int10--------
    rs1874092711,2
    --31824110(+) TGAATC/TTGTCT 2 -- ut31 nc-transcript-variant0--------
    rs1162124121,2
    C,F--31824176(+) TGCACC/AACCTT 2 -- ut31 nc-transcript-variant1Minor allele frequency- A:0.03WA 118
    rs35341,2
    C--31824253(+) ATGGAA/GTTGAA 2 -- ut31 nc-transcript-variant0--------
    rs1818574291,2
    --31824293(+) TAGCAA/TACTTA 2 -- ut31 nc-transcript-variant0--------

    HapMap Linkage Disequilibrium report for AMN1 (31824071 - 31882108 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for AMN1:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2667845CNV Deletion23128226
    esv2422415CNV Duplication17116639
    nsv662CNV Insertion18451855
    nsv898967CNV Loss21882294
    nsv898966CNV Gain21882294

    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    2 diseases for AMN1:    About MalaCards
    adrenoleukodystrophy    


    AMN1 for disorders           About GeneDecksing


    Export disorders for AMN1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for AMN1 gene integrated from 9 sources:
    (articles sorted by number of sources associating them with AMN1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
    2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1 Ota T.... Sugano S. (2004)
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 196394 HGNC: 27281 AceView: LOC196394 Ensembl:ENSG00000151743 euGenes: HUgn196394
    ECgene: AMN1 H-InvDB: AMN1

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for AMN1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for AMN1 gene:
    Search GeneIP for patents involving AMN1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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