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Aliases for AMN1 Gene

Aliases for AMN1 Gene

  • Antagonist Of Mitotic Exit Network 1 Homolog 2 3 5
  • Antagonist Of Mitotic Exit Network 1 Homolog (S. Cerevisiae) 2

External Ids for AMN1 Gene

Previous GeneCards Identifiers for AMN1 Gene

  • GC12M031716
  • GC12M031824
  • GC12M031576

Summaries for AMN1 Gene

GeneCards Summary for AMN1 Gene

AMN1 (Antagonist Of Mitotic Exit Network 1 Homolog) is a Protein Coding gene.

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for AMN1 Gene

Genomics for AMN1 Gene

Regulatory Elements for AMN1 Gene

Enhancers for AMN1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH12G031755 1.7 FANTOM5 Ensembl ENCODE dbSUPER 17.2 -26.7 -26654 2.1 HDAC1 TBL1XR1 TCF12 SCRT2 SIRT6 SMARCC1 USF2 ZEB2 ZNF579 ZNF589 AMN1 ENSG00000252204 H3F3C DSPA2D LOC105369724
GH12G031745 2.1 FANTOM5 Ensembl ENCODE dbSUPER 8.9 -18.9 -18940 6.9 MLX CREB3L1 FEZF1 DMAP1 YY1 SLC30A9 ZNF143 ZNF548 SP3 NFYC KIAA1551 H3F3C DSPA2D LOC100420981 DDX11-AS1 AMN1 ENSG00000256843
GH12G031905 1.4 FANTOM5 ENCODE dbSUPER 9.1 -176.2 -176178 2.1 SOX13 CTCF CBX3 ARID4B CEBPG ZNF384 EBF1 RAD21 CHAMP1 TEAD3 KIAA1551 AMN1 LINC02422 H3F3C RPLP2P4 GC12M031929
GH12G032050 1.8 FANTOM5 Ensembl ENCODE dbSUPER 6.9 -322.4 -322416 3.7 PKNOX1 FOXA2 ATF1 ARNT ZNF2 TCF12 GATA2 FOS CAVIN1 JUNB KIAA1551 H3F3C AMN1 ETFBKMT ENSG00000257852 ENSG00000257094
GH12G031832 1.6 FANTOM5 Ensembl ENCODE 6.8 -102.8 -102794 2.2 PKNOX1 FOXA2 ATF1 TCF12 ZNF766 FOS KLF13 CAVIN1 TBX21 ZNF592 H3F3C AMN1 ENSG00000252204 ENSG00000256372
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around AMN1 on UCSC Golden Path with GeneCards custom track

Promoters for AMN1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000050602 1392 1601 HDGF PKNOX1 MLX CREB3L1 ARNT ZFP64 WRNIP1 ARID4B SIN3A DMAP1

Genomic Location for AMN1 Gene

Chromosome:
12
Start:
31,671,137 bp from pter
End:
31,730,392 bp from pter
Size:
59,256 bases
Orientation:
Minus strand

Genomic View for AMN1 Gene

Genes around AMN1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
AMN1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for AMN1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for AMN1 Gene

Proteins for AMN1 Gene

  • Protein details for AMN1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8IY45-AMN1_HUMAN
    Recommended name:
    Protein AMN1 homolog
    Protein Accession:
    Q8IY45
    Secondary Accessions:
    • B7Z7J3
    • Q6NVU4
    • Q86X98

    Protein attributes for AMN1 Gene

    Size:
    258 amino acids
    Molecular mass:
    28408 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH37897.3; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAH45831.2; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAH67906.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for AMN1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for AMN1 Gene

Post-translational modifications for AMN1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for AMN1 Gene

Domains & Families for AMN1 Gene

Protein Domains for AMN1 Gene

Suggested Antigen Peptide Sequences for AMN1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8IY45

UniProtKB/Swiss-Prot:

AMN1_HUMAN :
  • Belongs to the AMN1 family.
Family:
  • Belongs to the AMN1 family.
genes like me logo Genes that share domains with AMN1: view

No data available for Gene Families for AMN1 Gene

Function for AMN1 Gene

genes like me logo Genes that share phenotypes with AMN1: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for AMN1 Gene

Localization for AMN1 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for AMN1 gene
Compartment Confidence
extracellular 2
plasma membrane 1
mitochondrion 1
nucleus 1
cytosol 1
lysosome 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for AMN1 Gene

Pathways & Interactions for AMN1 Gene

No Data Available

Interacting Proteins for AMN1 Gene

Selected Interacting proteins: Q8IY45-AMN1_HUMAN for AMN1 Gene via IID

Symbol External ID(s) Details
UBR2

Gene Ontology (GO) - Biological Process for AMN1 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for AMN1 Gene

Transcripts for AMN1 Gene

Unigene Clusters for AMN1 Gene

Antagonist of mitotic exit network 1 homolog (S. cerevisiae):
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for AMN1 Gene

ExUns: 1a · 1b · 1c · 1d · 1e · 1f ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9a · 9b ^ 10a · 10b · 10c · 10d ^ 11
SP1: -
SP2: - - - -
SP3: - - - - -
SP4: - - - - -
SP5: - -
SP6:
SP7: - - -

Relevant External Links for AMN1 Gene

GeneLoc Exon Structure for
AMN1
ECgene alternative splicing isoforms for
AMN1

Expression for AMN1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for AMN1 Gene

Protein differential expression in normal tissues from HIPED for AMN1 Gene

This gene is overexpressed in Testis (36.3) and Ovary (28.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for AMN1 Gene



Protein tissue co-expression partners for AMN1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of AMN1 Gene:

AMN1

SOURCE GeneReport for Unigene cluster for AMN1 Gene:

Hs.585084

Evidence on tissue expression from TISSUES for AMN1 Gene

  • Nervous system(3.9)
genes like me logo Genes that share expression patterns with AMN1: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for AMN1 Gene

Orthologs for AMN1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for AMN1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia AMN1 34 35
  • 99.61 (n)
dog
(Canis familiaris)
Mammalia AMN1 34 35
  • 91.09 (n)
cow
(Bos Taurus)
Mammalia AMN1 34 35
  • 90.96 (n)
rat
(Rattus norvegicus)
Mammalia Amn1 34
  • 83.2 (n)
mouse
(Mus musculus)
Mammalia Amn1 34 16 35
  • 82.17 (n)
oppossum
(Monodelphis domestica)
Mammalia AMN1 35
  • 80 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia AMN1 35
  • 72 (a)
OneToOne
chicken
(Gallus gallus)
Aves AMN1 34 35
  • 70.37 (n)
lizard
(Anolis carolinensis)
Reptilia AMN1 35
  • 65 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100485350 34
  • 59.67 (n)
zebrafish
(Danio rerio)
Actinopterygii amn1 34 35
  • 55.56 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes AMN1 37
Species where no ortholog for AMN1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for AMN1 Gene

ENSEMBL:
Gene Tree for AMN1 (if available)
TreeFam:
Gene Tree for AMN1 (if available)

Paralogs for AMN1 Gene

genes like me logo Genes that share paralogs with AMN1: view

No data available for Paralogs for AMN1 Gene

Variants for AMN1 Gene

Sequence variations from dbSNP and Humsavar for AMN1 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs1000050426 -- 31,701,475(+) TTTTT(G/T)GTAGA intron-variant
rs1000106667 -- 31,682,737(+) TTGAG(A/C)TAACA intron-variant
rs1000161298 -- 31,689,503(+) GAAAA(C/G)AGCTA intron-variant
rs1000201362 -- 31,696,167(+) GGGAC(A/G)TGGAA intron-variant
rs1000209549 -- 31,682,528(+) GGTGT(C/T)TCTGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for AMN1 Gene

Variant ID Type Subtype PubMed ID
esv2422415 CNV duplication 17116639
esv2667845 CNV deletion 23128226
esv2760267 CNV gain+loss 21179565
esv3629053 CNV loss 21293372
nsv1050448 CNV gain 25217958
nsv473227 CNV novel sequence insertion 20440878
nsv558100 CNV gain 21841781
nsv558101 CNV gain 21841781
nsv662 CNV insertion 18451855

Variation tolerance for AMN1 Gene

Residual Variation Intolerance Score: 33.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.30; 6.73% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for AMN1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
AMN1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for AMN1 Gene

Disorders for AMN1 Gene

Relevant External Links for AMN1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
AMN1

No disorders were found for AMN1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for AMN1 Gene

Publications for AMN1 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  2. Interrogation of the platelet-derived growth factor receptor alpha locus and corneal astigmatism in Australians of Northern European ancestry: results of a genome-wide association study. (PMID: 23761726) Yazar S. … Hewitt A.W. (Mol. Vis. 2013) 3 64
  3. The finished DNA sequence of human chromosome 12. (PMID: 16541075) Scherer S.E. … Gibbs R.A. (Nature 2006) 4 64
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 4 64
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3 64

Products for AMN1 Gene

Sources for AMN1 Gene

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