AMN1 Gene
protein-coding GIFtS: 45
GCID: GC12M031824
|
|
antagonist of mitotic exit network 1 homolog (S. cerevisiae)
| |
Aliases
for AMN1 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA
Quality score for the ORGUL clustered with this gene is 3
| Aliases |
|---|
| Antagonist Of Mitotic Exit Network 1 Homolog (S. Cerevisiae)1 2 | | Protein AMN1 Homolog2 |
| External Ids: | HGNC: 272811 | Entrez Gene: 1963942 | Ensembl: ENSG000001517437 | UniProtKB: Q8IY453 | | ORGUL members: | |
|---|
| NONCODE:n406340 | |
Export aliases for AMN1 gene to outside databasesPrevious GC identifers: GC12M031716 GC12M031576
|---|
Summaries
for AMN1 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for AMN1 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000012.11 NC_018923.1 NT_009714.17
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the AMN1 gene promoter:
GR Elk-1 GATA-3 Lmo2 Nkx5-1 Evi-1 GATA-1 GATA-2 Arnt GR-alpha
Other transcription factors
Search SABiosciences Chromatin IP Primers for AMN1
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat AMN1 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 12p11.21 Ensembl cytogenetic band: 12p11.21 HGNC cytogenetic band: 12p11.21AMN1 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 12 GeneLoc Exon Structure GeneLoc location for GC12M031824: view genomic region
(about GC identifiers)
Start:
|
31,824,071 bp from pter |
End:
|
31,882,108 bp from pter |
Size:
|
58,038 bases |
Orientation:
|
minus strand |
|
Proteins
for AMN1 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: AMN1_HUMAN, Q8IY45 (See
protein sequence)Recommended Name: Protein AMN1 homolog Size: 258 amino acids; 28408 Da
Sequence caution: Sequence=AAH37897.3; Type=Erroneous initiation; Sequence=AAH45831.2; Type=Erroneous initiation;Sequence=AAH67906.1; Type=Erroneous initiation;
Secondary accessions: Q6NVU4 Q86X98Explore the universe of human proteins at neXtProt for AMN1: NX_Q8IY45
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q8IY45
AMN1 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_001106873.1
ENSEMBL proteins: ENSP00000281471 ENSP00000441419 ENSP00000439171 ENSP00000440967 ENSP00000442272 ENSP00000438990 ENSP00000441846 ENSP00000439438 ENSP00000396145
Human Recombinant Protein Products:
AMN1 Antibody Products:
Assay Products for AMN1: |
Protein
Domains /
Families
for AMN1 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
AMN1 for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q8IY45ProtoNet protein and cluster: Q8IY45 UniProtKB/Swiss-Prot: AMN1_HUMAN, Q8IY45Similarity: Belongs to the AMN1 family |
Function
for AMN1 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for AMN1 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for AMN1
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: AMN1 (NM_001113402) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for AMN1 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat AMN1 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for AMN1 |
2 GenomeRNAi human phenotypes for AMN1:
|
Pathways & Interactions
for AMN1 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for AMN1
|
Drugs & Compounds
for AMN1 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for AMN1
Search CenterWatch for drugs/clinical trials and news about AMN1
|
Transcripts
for AMN1 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for AMN1 gene: NM_001113402.1 Unigene Cluster for AMN1: Antagonist of mitotic exit network 1 homolog (S. cerevisiae) Hs.585084 [show with all ESTs]Unigene Representative Sequence: NM_00111340212 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000281471(uc001rkq.4 uc001rko.4 uc010skc.2 uc009zjs.3)
ENST00000537562 ENST00000541931 ENST00000536761 ENST00000542781(uc009zjt.1)
ENST00000535408 ENST00000537960 ENST00000506446 ENST00000457428 ENST00000541541
ENST00000422146 ENST00000509386
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for AMN1 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for AMN1
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: AMN1 (NM_001113402) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for AMN1 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat AMN1 |
Additional cDNA sequence: AK123033.1 AK302112.1 AK311214.1 AK311249.1 AL833434.1 BC037897.2 BC045831.1 BC067906.1 NR_004854.1 8 DOTS entries: DT.307269 DT.100754535 DT.95172234 DT.40261427 DT.92423658 DT.100836897 DT.121186781 DT.97791119 24/122 AceView cDNA sequences (see all 122): CA867775 BU629034 N66589 AK123033 AA931787 BU193172 AI471734 AW079529 BE792595 BM756838 N45121 CA429807 AA280156 BM462699 BC045831 BM713242 AA829949 CD675541 BM799513 CR608460 BM756754 AV715011 CR618732 CR598985
GeneLoc Exon Structure
5/7 Alternative Splicing Database (ASD) splice patterns (SP) for AMN1 (see all 7) About this scheme
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | · | 1e | · | 1f | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8a | · | 8b | ^ | 9a | · | 9b | ^ | 10a | · | 10b | · | 10c | · | 10d | ^ | 11 |
|---|
|
| SP1: | | | | | | | | | | | | | | | | | | | | | - | | | | | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | - | | - | | - | | | | - | | | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | - | | - | | - | | - | | - | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | - | | - | | - | | - | | | | - | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | - | | | | - | | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for AMN1
|
Expression
for AMN1 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| AMN1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: AGCCAGTCTT
About this image
See AMN1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for AMN1
SOURCE GeneReport for Unigene cluster: Hs.585084
SABiosciences Custom PCR Arrays for AMN1
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for AMN1
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse / rat AMN1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat AMN1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat AMN1 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for AMN1 |
Orthologs
for AMN1 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for AMN1 gene from 6/17 species (see all 17) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
AMN11 |
antagonist of mitotic exit network 1 homolog (S. cerevisiae) |
71.75(n)
69.88(a) |
|
418137 XM_416368.2 XP_416368.1 |
lizard
(Anolis carolinensis) |
Reptilia |
AMN16 |
-- |
68(a) |
1 ↔ 1 |
5(10629393-10648406) |
tropical clawed frog
(Xenopus tropicalis) |
Amphibia |
BX746347.12 |
-- |
71.37(n) |
|
BX746347.1 |
zebrafish
(Danio rerio) |
Actinopterygii |
amn11 |
antagonist of mitotic exit network 1 homolog (S. cerevisiae) |
55.56(n)
47.56(a) |
|
751744 NM_001045454.1 NP_001038919.1 |
thale cress
(Arabidopsis thaliana) |
eudicotyledons |
AT2G170206AT1G555906 |
F-box protein At-B |
8(a)8(a) |
many ↔ manymany ↔ many |
2(7396337-7398838) 1(20769320-20771871) |
rice
(Oryza sativa) |
Liliopsida |
---- |
F-box protein At-B, putative, expressed |
8(a)8(a) |
many ↔ manymany ↔ many |
3(1955855-1958795) 8(24674869-24677686) |
ENSEMBL Gene Tree for AMN1 (if available)
TreeFam Gene Tree for AMN1 (if available) |
Paralogs
for AMN1 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for AMN1 gene
- FBXL172 FBXL22 FBXL202 ENSG000002371022 FBXL132 FBXL162 FBXL72 LRRC292
- FBXL152 FBXL42 FBXL142
13 SIMAP similar genes for AMN1 using alignment to 7 protein entries: AMN1_HUMAN (see all proteins):LOC196394 PLA2G15 PACSIN2 DNAAF1 FAM138A FAM138B
FAM138C FAM138F FAM138D EYS APCDD1 OK/SW-cl.41
UTY
AMN1 for paralogs About GeneDecksing
|
Genomic Variants
for AMN1 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 12 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for AMN1 (31824071 - 31882108 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for AMN1
1 CNV: 5289 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing AMN1 |
|
Disorders
/ Diseases
for AMN1 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
AMN1 for disorders About GeneDecksing
1  disease for AMN1: About MalaCardsadrenoleukodystrophy
Export disorders for AMN1 gene to outside databases
|
Publications
for AMN1 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for AMN1 gene integrated from 9 sources:
(articles sorted by number of sources associating them with AMN1) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1 Ota T.... Sugano S. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
|
External Searches for AMN1 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing AMN1 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing AMN1 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing AMN1 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for AMN1 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for AMN1 gene:
Search GeneIP for patents involving AMN1
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for AMN1 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for AMN1 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for AMN1 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for AMN1 | | | OriGene Protein Over-expression Lysate for AMN1 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for AMN1 | | OriGene 3'-UTR Clone for AMN1 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for AMN1 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for AMN1 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for AMN1 | | OriGene Custom Protein Services for AMN1 | | | OriGene Custom Immunoassay Development | | |
| |
 |
 |
| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat AMN1 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing AMN1 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat AMN1 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat AMN1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat AMN1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat AMN1 |
| |
 |  |  |  | |
| | | | Search Tocris compounds for AMN1 |
| |  |  |  |  | | | | |
 |
 |
 |
 | | | AMN1 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for AMN1 |
|  |  |  | | | | ThermoFisher Antibodies for AMN1 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat AMN1 |
|
|
|
|
GeneCards Homepage -
Last full update: 18 Mar 2013 -
Incrementals: 21 Mar 2013 , 15 Apr 2013 , 27 Apr 2013
View Random Gene
|
Category
|
|
|
von Willebrand factor
|
| GIFtS Group |
|
Developed at the Crown Human Genome Center,
Department of Molecular Genetics,
the Weizmann Institute of Science
Copyright © 1996-2013
, Weizmann Institute of Science. All Rights Reserved.
hostname: 356980-web2.xennexinc.com
index build: 100 solr: 1.4
|
