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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

AMN Gene

protein-coding   GIFtS: 56
GCID: GC14P103388

Amnion Associated Transmembrane Protein

(Previous name: amnionless homolog (mouse))
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Amnion Associated Transmembrane Protein1 2     Amnionless Homolog2
Amnionless Homolog (Mouse)1     Protein Amnionless2
PRO10282     Visceral Endoderm-Specific Type 1 Transmembrane Protein2
amnionless2     

External Ids:    HGNC: 146041   Entrez Gene: 816932   Ensembl: ENSG000001661267   OMIM: 6057995   UniProtKB: Q9BXJ73   

Export aliases for AMN gene to outside databases

Previous GC identifers: GC14P100780 GC14P097204 GC14P101379 GC14P102458 GC14P083564


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for AMN Gene:
The protein encoded by this gene is a type I transmembrane protein. It is thought to modulate bone morphogenetic
protein (BMP) receptor function by serving as an accessory or coreceptor, and thus facilitates or hinders BMP
binding. It is known that the mouse AMN gene is expressed in the extraembryonic visceral endoderm layer during
gastrulation, but it is found to be mutated in amnionless mouse. The encoded protein has sequence similarity to
short gastrulation (Sog) and procollagen IIA proteins in Drosophila. (provided by RefSeq, Jul 2008)

GeneCards Summary for AMN Gene: 
AMN (amnion associated transmembrane protein) is a protein-coding gene. Diseases associated with AMN include megaloblastic anemia-1, norwegian type, and megaloblastic anemia 1, and among its related super-pathways are Lipoprotein metabolism and Metabolism of water-soluble vitamins and cofactors.

UniProtKB/Swiss-Prot: AMNLS_HUMAN, Q9BXJ7
Function: Necessary for efficient absorption of vitamin B12. May direct the production of trunk mesoderm during
development by modulating a bone morphogenetic protein (BMP) signaling pathway in the underlying visceral
endoderm (By similarity)

Gene Wiki entry for AMN (Amnionless) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000014.8  NC_018925.2  NT_026437.12  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the AMN gene promoter:
         Elk-1   HSF1 (long)   LUN-1   MIF-1   GATA-1   CREB   Max   Chx10   HSF1short   c-Myc   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidAMN promoter sequence
   Search SABiosciences Chromatin IP Primers for AMN

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat AMN


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 14q32.3   Ensembl cytogenetic band:  14q32.32   HGNC cytogenetic band: 14q32.32

AMN Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
AMN gene location

GeneLoc information about chromosome 14         GeneLoc Exon Structure

GeneLoc location for GC14P103388:  view genomic region     (about GC identifiers)

Start:
103,388,993 bp from pter      End:
103,399,933 bp from pter
Size:
10,941 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: AMNLS_HUMAN, Q9BXJ7 (See protein sequence)
Recommended Name: Protein amnionless precursor  
Size: 453 amino acids; 47754 Da
Subunit: Interacts with CUBN/cubilin
Subcellular location: Membrane; Single-pass type I membrane protein (Potential)
Miscellaneous: The mutations described in PubMed:12590260 all affect the N-terminus of the protein; shorter
isoforms produced from alternative transcription start sites might still fulfill a role in embryogenesis. This
might explain the discrepancy with the embryonic lethality of null mutants in mice
Secondary accessions: Q6UX83
Alternative promoter usage: 1 isoform:  Q9BXJ7-1   

Explore the universe of human proteins at neXtProt for AMN: NX_Q9BXJ7

Explore proteomics data for AMN at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9BXJ7

  • AMN Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    AMN Protein Expression
    REFSEQ proteins: NP_112205.2  
    ENSEMBL proteins: 
     ENSP00000299155   ENSP00000453786   ENSP00000452831  
    Reactome Protein details: Q9BXJ7
    Human Recombinant Protein Products for AMN: 
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    Cloud-Clone Corp. Proteins for AMN 

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0010008endosome membrane TAS--
    GO:0016021integral to membrane IEA--
    GO:0045177apical part of cell IEA--

    AMN for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    1 InterPro protein domain:
     IPR026112 AMN

    Graphical View of Domain Structure for InterPro Entry Q9BXJ7

    ProtoNet protein and cluster: Q9BXJ7

    1 Blocks protein domain: IPB001007 von Willebrand factor

    UniProtKB/Swiss-Prot: AMNLS_HUMAN, Q9BXJ7
    Similarity: Contains 1 VWFC domain


    AMN for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: AMNLS_HUMAN, Q9BXJ7
    Function: Necessary for efficient absorption of vitamin B12. May direct the production of trunk mesoderm during
    development by modulating a bone morphogenetic protein (BMP) signaling pathway in the underlying visceral
    endoderm (By similarity)

    Phenotypes:
         1 GenomeRNAi human phenotype for AMN:

     Decreased influenza A/WSN/33 r 

         4 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Amn):
     cellular  embryogenesis  mortality/aging  nervous system 

    AMN for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for AMN 
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for AMN 
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for AMN About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Lipoprotein metabolism
    Lipoprotein metabolism0.57
    Lipid digestion, mobilization, and transport0.56
    HDL-mediated lipid transport0.57
    2Metabolism of vitamins and cofactors
    Metabolism of water-soluble vitamins and cofactors1.00
    Metabolism of vitamins and cofactors1.00
    3Metabolism
    Metabolism0.40
    Metabolism of lipids and lipoproteins0.34
    4Cobalamin (Cbl, vitamin B12) transport and metabolism
    Cobalamin (Cbl, vitamin B12) transport and metabolism

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    5/8        Reactome Pathways for AMN (see all 8)
        Lipid digestion, mobilization, and transport
    Metabolism
    Lipoprotein metabolism
    Cobalamin (Cbl, vitamin B12) transport and metabolism
    Metabolism of vitamins and cofactors



    AMN for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for AMN

    STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

    2 Interacting proteins for AMN (Q9BXJ73 ENSP000002991554) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    STAMBPO956303, ENSP000003447424I2D: score=1 STRING: ENSP00000344742
    ABCD3ENSP000003592334STRING: ENSP00000359233
    About this table

    Gene Ontology (GO): 5/8 biological process terms (GO ID links to tree view) (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006766vitamin metabolic process TAS--
    GO:0006767water-soluble vitamin metabolic process TAS--
    GO:0007275multicellular organismal development IEA--
    GO:0007588excretion IEA--
    GO:0008104protein localization IEA--

    AMN for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for AMN (AMNLS)

    1 HMDB Compound for AMN    About this table
    CompoundSynonyms CAS #PubMed Ids
    CyanocobalaminDimethylbenzimidazoylcobamide (see all 92)68-19-9--

    2 DrugBank Compounds for AMN    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    HydroxocobalaminHydroxomin (see all 2)13422-51-0targetother17139284 17016423 14585166
    CyanocobalaminCyanocob(III)alamin (see all 3)68-19-9transportersubstrate16047053

    Search CenterWatch for drugs/clinical trials and news about AMN / AMNLS

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for AMN gene: 
    NM_030943.3  

    Unigene Cluster for AMN:

    Amnion associated transmembrane protein
    Hs.534494  [show with all ESTs]
    Unigene Representative Sequence: AK055802
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000299155(uc001ymg.4) ENST00000541086(uc001ymh.4) ENST00000558590
    ENST00000559442 ENST00000559525 ENST00000559789 ENST00000559507
    miRNA
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    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate AMN
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    Inhib. RNA
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat AMN
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat AMN

    Additional mRNA sequence: 

    AF328788.1 AK055802.1 AY358468.1 BC029948.1 

    6 DOTS entries:

    DT.105025  DT.86855352  DT.75157682  DT.100819449  DT.120773073  DT.86855351 

    24/232 AceView cDNA sequences (see all 232):

    AW271510 AI590326 AW166462 AI984122 AW612393 AI380930 AI817659 AI287710 
    AI244097 BF590640 CB306421 AI673487 BU528630 AI582193 AI985332 AW025223 
    AI356483 AW139944 AW004726 BF222455 AW299664 BF940292 CA949960 AI364952 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    AMN expression in normal human tissues (normalized intensities)      AMN embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CGGGAGTCGG
    AMN Expression
    About this image


    AMN expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/6 selected tissues (see all 6) fully expand
     
     Hypoblast (Extraembryonic Tissues)    fully expand to see all 4 entries
             Visceral Endoderm Cells Visceral Endoderm
     
     Yolk Sac (Extraembryonic Tissues)    fully expand to see all 3 entries
             Visceral Endoderm Cells Visceral Endoderm
     
     Colon (Gastrointestinal Tract)
             colonic mucosa   
     
     Epiblast (Early Embryonic Tissues)
             Early Epiblast Cells Epiblast
     
     Blood (Hematopoietic System)
             cd14+ cells   

    See AMN Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for AMN

    SOURCE GeneReport for Unigene cluster: Hs.534494

    UniProtKB/Swiss-Prot: AMNLS_HUMAN, Q9BXJ7
    Tissue specificity: Long isoforms are highly expressed in small intestine, colon and kidney (renal proximal tubule
    epithelial cells). Shorter isoforms are detected at lower levels in testis, thymus and peripheral blood
    leukocytes

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for AMN gene from 5/11 species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Amn1 , 5 amnionless1, 5 76.45(n)1
    69.75(a)1
      12 (60.94 cM)5
    938351  NM_033603.21  NP_291081.21 
     1112711115 
    chicken
    (Gallus gallus)
    Aves AMN1 amnionless homolog (mouse) 55.74(n)
    41.69(a)
      423472  XM_421379.2  XP_421379.2 
    lizard
    (Anolis carolinensis)
    Reptilia AMN6
    amnion associated transmembrane protein
    34(a)
    1 ↔ 1
    GL343232.1(948852-1064864)
    zebrafish
    (Danio rerio)
    Actinopterygii im:71558951 im:7155895 49.92(n)
    39.95(a)
      793454  XM_002661272.2  XP_002661318.2 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG115926
    --
    16(a)
    1 ↔ 1
    2L(287252-289144)


    ENSEMBL Gene Tree for AMN (if available)
    TreeFam Gene Tree for AMN (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/273 SNPs in AMN are shown (see all 273)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 14 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0157334
    Recessive hereditary megaloblastic anemia 1 (RH-MGA1)4--see VAR_0157332 T I mis40--------
    rs1156605891,2
    C,F--84378836(+) CCATCC/TACCAT 1 -- us2k11Minor allele frequency- T:0.07WA 118
    rs1398312891,2
    --84379087(+) CTATTC/TATCTT 1 -- us2k10--------
    rs1453645701,2
    --84379117(+) CTATCA/TTCCAC 1 -- us2k10--------
    rs762212441,2
    C,F--84379483(+) CAAACA/GTCCAC 1 -- us2k12Minor allele frequency- G:0.11WA NA 238
    rs1121180581,2
    C--84379502(+) CCCACT/-TTTTT 1 -- us2k11Minor allele frequency- -:0.50CSA 2
    rs49062741,2
    C,F,A--84379554(+) gcacaG/Atggcg 1 -- us2k18Minor allele frequency- A:0.28NA WA CSA EA 131
    rs1892378441,2
    --84379567(+) ATCTCC/TGATCA 1 -- us2k10--------
    rs1156990871,2
    F--84379580(+) ACAACC/TTCCGC 1 -- us2k11Minor allele frequency- T:0.01WA 118
    rs1431260631,2
    --84379735(+) CAGGTC/GATCTG 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for AMN (103388993 - 103399933 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for AMN:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv509552CNV Insertion20534489
    dgv1985n71CNV Loss21882294
    nsv902263CNV Loss21882294
    nsv9167CNV Gain18304495
    nsv483032CNV Gain15286789


    Human Gene Mutation Database (HGMD): AMN
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing AMN
    DNA2.0 Custom Variant and Variant Library Synthesis for AMN

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 605799   
    OMIM disorders: 261100  
    UniProtKB/Swiss-Prot: AMNLS_HUMAN, Q9BXJ7
  • Recessive hereditary megaloblastic anemia 1 (RH-MGA1) [MIM:261100]: Due to selective malabsorption of
    vitamin B12. Defects in vitamin B12 absorption lead to impaired function of thymidine synthase. As a consequence
    DNA synthesis is interrupted. Rapidly dividing cells involved in erythropoiesis are particularly affected.
    Note=The disease is caused by mutations affecting the gene represented in this entry

  • 9 diseases for AMN:    About MalaCards
    megaloblastic anemia-1, norwegian type    megaloblastic anemia 1    imerslund-grasbeck syndrome    peroxisomal disease
    adrenoleukodystrophy    megaloblastic anemia    birth defects    addison's disease
    anemia


    AMN for disorders           About GeneDecksing


    Export disorders for AMN gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for AMN gene, integrated from 9 sources (see all 25):
    (articles sorted by number of sources associating them with AMN)
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    1. The amnionless gene, essential for mouse gastrulation, encodes a visceral-endoderm-specific protein with an extracellular cysteine-rich domain. (PubMed id 11279523)1, 2, 3 Kalantry S.... Lacy E. (2001)
    2. Amnionless, essential for mouse gastrulation, is mutated in recessive hereditary megaloblastic anemia. (PubMed id 12590260)1, 2, 9 Tanner S.M.... de la Chapelle A. (2003)
    3. The functional cobalamin (vitamin B12)-intrinsic factor receptor is a novel complex of cubilin and amnionless. (PubMed id 14576052)1, 2 Fyfe J.C.... Moestrup S.K. (2004)
    4. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (2003)
    5. Variations of the Amnionless gene in recurrent spontaneous abortions. (PubMed id 16403802)1, 9 Kaare M....Aittomaki K. (2006)
    6. Imerslund-Grasbeck syndrome: new mutation in amnionless. (PubMed id 22631584)2 Densupsoontorn N.... Tanner S.M. (2012)
    7. Inherited cobalamin malabsorption. Mutations in three genes reveal functional and ethnic patterns. (PubMed id 22929189)1 Tanner S.M....de la Chapelle A. (2012)
    8. Luminal expression of cubilin is impaired in Imerslund -Grasbeck syndrome with compound AMN mutations in intron 3 and exon 7. (PubMed id 21750092)1 Namour F....Gueant J.L. (2011)
    9. Ancient founder mutation is responsible for Imerslund- Grasbeck Syndrome among diverse ethnicities. (PubMed id 22078000)1 Beech C.M....Tanner S.M. (2011)
    10. Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348)1 Barbe L....Andersson-Svahn H. (2008)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 81693 HGNC: 14604 AceView: AMN Ensembl:ENSG00000166126 euGenes: HUgn81693
    ECgene: AMN H-InvDB: AMN

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for AMN Pharmacogenomics, SNPs, Pathways
    GeneReviewshttp://www.ncbi.nlm.nih.gov/sites/GeneTests/lab/gene/AMN

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for AMN gene:
    Search GeneIP for patents involving AMN

    GeneCards and IP:
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