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AMN Gene

protein-coding   GIFtS: 56
GCID: GC14P103388

Amnion Associated Transmembrane Protein

(Previous name: amnionless homolog (mouse))
  See AMN-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Amnion Associated Transmembrane Protein1 2     Amnionless Homolog2
Amnionless Homolog (Mouse)1     Protein Amnionless2
PRO10282     Visceral Endoderm-Specific Type 1 Transmembrane Protein2
amnionless2     

External Ids:    HGNC: 146041   Entrez Gene: 816932   Ensembl: ENSG000001661267   OMIM: 6057995   UniProtKB: Q9BXJ73   

Export aliases for AMN gene to outside databases

Previous GC identifers: GC14P100780 GC14P097204 GC14P101379 GC14P102458 GC14P083564


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for AMN Gene:
The protein encoded by this gene is a type I transmembrane protein. It is thought to modulate bone morphogenetic
protein (BMP) receptor function by serving as an accessory or coreceptor, and thus facilitates or hinders BMP
binding. It is known that the mouse AMN gene is expressed in the extraembryonic visceral endoderm layer during
gastrulation, but it is found to be mutated in amnionless mouse. The encoded protein has sequence similarity to
short gastrulation (Sog) and procollagen IIA proteins in Drosophila. (provided by RefSeq, Jul 2008)

GeneCards Summary for AMN Gene:
AMN (amnion associated transmembrane protein) is a protein-coding gene. Diseases associated with AMN include methylmalonic aciduria and homocystinuria type cble, and adrenomyeloneuropathy, adult.

UniProtKB/Swiss-Prot: AMNLS_HUMAN, Q9BXJ7
Function: Necessary for efficient absorption of vitamin B12. May direct the production of trunk mesoderm during
development by modulating a bone morphogenetic protein (BMP) signaling pathway in the underlying visceral
endoderm (By similarity)

Gene Wiki entry for AMN (Amnionless) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000014.8  NC_018925.2  NT_026437.13  
Regulatory elements:
   Regulatory transcription factor binding sites in the AMN gene promoter:
         Elk-1   HSF1 (long)   LUN-1   MIF-1   GATA-1   CREB   Max   Chx10   HSF1short   c-Myc   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidAMN promoter sequence
   Search Chromatin IP Primers for AMN

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat AMN


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 14q32.3   Ensembl cytogenetic band:  14q32.32   HGNC cytogenetic band: 14q32.32

AMN Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
AMN gene location

GeneLoc information about chromosome 14         GeneLoc Exon Structure

GeneLoc location for GC14P103388:  view genomic region     (about GC identifiers)

Start:
103,388,993 bp from pter      End:
103,399,933 bp from pter
Size:
10,941 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: AMNLS_HUMAN, Q9BXJ7 (See protein sequence)
Recommended Name: Protein amnionless precursor  
Size: 453 amino acids; 47754 Da
Subunit: Interacts with CUBN/cubilin
Miscellaneous: The mutations described in PubMed:12590260 all affect the N-terminus of the protein; shorter
isoforms produced from alternative transcription start sites might still fulfill a role in embryogenesis. This
might explain the discrepancy with the embryonic lethality of null mutants in mice
Secondary accessions: Q6UX83
Alternative promoter usage: 1 isoform:  Q9BXJ7-1   

Explore the universe of human proteins at neXtProt for AMN: NX_Q9BXJ7

Explore proteomics data for AMN at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn35
  • Modification sites at PhosphoSitePlus

  • See AMN Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_112205.2  
    ENSEMBL proteins: 
     ENSP00000299155   ENSP00000453786   ENSP00000452831  
    Reactome Protein details: Q9BXJ7

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR026112 AMN

    Graphical View of Domain Structure for InterPro Entry Q9BXJ7

    ProtoNet protein and cluster: Q9BXJ7

    1 Blocks protein domain: IPB001007 von Willebrand factor

    UniProtKB/Swiss-Prot: AMNLS_HUMAN, Q9BXJ7
    Similarity: Contains 1 VWFC domain


    Find genes that share domains with AMN           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: AMNLS_HUMAN, Q9BXJ7
    Function: Necessary for efficient absorption of vitamin B12. May direct the production of trunk mesoderm during
    development by modulating a bone morphogenetic protein (BMP) signaling pathway in the underlying visceral
    endoderm (By similarity)

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005102receptor binding IPI14576052
         
    Find genes that share ontologies with AMN           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for AMN:
     Decreased influenza A/WSN/33 r 

         4 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Amn):
     cellular  embryogenesis  mortality/aging  nervous system 

    Find genes that share phenotypes with AMN           About GenesLikeMe

    Animal Models:
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    AMNLS_HUMAN, Q9BXJ7: Membrane; Single-pass type I membrane protein (Potential)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane4
    extracellular2
    cytoskeleton1
    cytosol1
    golgi apparatus1
    lysosome1
    mitochondrion1
    nucleus1

    Gene Ontology (GO): Selected cellular component terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005615extracellular space IDA14576052
    GO:0005886plasma membrane TAS--
    GO:0010008endosome membrane TAS--
    GO:0016021integral component of membrane IEA--
    GO:0016324apical plasma membrane IDA14576052

    Find genes that share ontologies with AMN           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for AMN About    
    See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1Defective BTD causes biotidinase deficiency
    Defective BTD causes biotidinase deficiency1.00
    Metabolism of vitamins and cofactors1.00
    Defective AMN causes hereditary megaloblastic anemia 11.00
    Defective MMACHC causes methylmalonic aciduria and homocystinuria type cblC1.00
    Defective MMAA causes methylmalonic aciduria type cblA1.00
    Defective MUT causes methylmalonic aciduria mut type1.00
    Defective CD320 causes methylmalonic aciduria1.00
    Defects in cobalamin (B12) metabolism1.00
    2Lipoprotein metabolism
    Lipoprotein metabolism0.59
    HDL-mediated lipid transport0.00
    Lipid digestion, mobilization, and transport0.59
    3Metabolism
    Metabolism0.38
    Metabolism of lipids and lipoproteins0.37
    4Disease
    Disease


    Find genes that share SuperPaths with AMN           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    4 Reactome Pathways for AMN
        Defective AMN causes hereditary megaloblastic anemia 1
    Cobalamin (Cbl, vitamin B12) transport and metabolism
    HDL-mediated lipid transport
    Defective CUBN causes hereditary megaloblastic anemia 1


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for AMN
    Interactions:

        GeneGlobe Interaction Network for AMN

    STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

    2 Interacting proteins for AMN (Q9BXJ73 ENSP000002991554) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    STAMBPO956303, ENSP000003447424I2D: score=1 STRING: ENSP00000344742
    ABCD3ENSP000003592334STRING: ENSP00000359233
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 11):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006766vitamin metabolic process TAS--
    GO:0006767water-soluble vitamin metabolic process TAS--
    GO:0006898receptor-mediated endocytosis IDA14576052
    GO:0007275multicellular organismal development IEA--
    GO:0007588excretion IEA--

    Find genes that share ontologies with AMN           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for AMN (AMNLS)

    1 HMDB Compound for AMN    About this table
    CompoundSynonyms CAS #PubMed Ids
    CyanocobalaminDimethylbenzimidazoylcobamide (see all 92)68-19-9--

    2 DrugBank Compounds for AMN    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    HydroxocobalaminHydroxomin (see all 2)13422-51-0targetother17139284 17016423 14585166
    CyanocobalaminCyanocob(III)alamin (see all 3)68-19-9transportersubstrate16047053



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for AMN gene: 
    NM_030943.3  

    Unigene Cluster for AMN:

    Amnion associated transmembrane protein
    Hs.534494  [show with all ESTs]
    Unigene Representative Sequence: AK055802
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000299155(uc001ymg.4) ENST00000541086(uc001ymh.4) ENST00000558590
    ENST00000559442 ENST00000559525 ENST00000559789 ENST00000559507
    miRNA
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    Additional mRNA sequence: 

    AF328788.1 AK055802.1 AY358468.1 BC029948.1 

    6 DOTS entries:

    DT.105025  DT.86855352  DT.75157682  DT.100819449  DT.120773073  DT.86855351 

    Selected AceView cDNA sequences (see all 232):

    AW166462 AI582193 BU786498 AI521944 AI984122 AW271510 AI986048 BF591179 
    AI287700 AI565422 AI589201 AW271607 BF197343 AI364952 AW299755 AW195657 
    BF002499 AI925876 AW016311 AW612393 AI822025 AI521943 AW006866 AI733056 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    AMN expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CGGGAGTCGG
    AMN Expression
    About this image


    AMN expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 5) fully expand
     
     Hypoblast (Extraembryonic Tissues)    fully expand to see all 4 entries
             Visceral Endoderm Cells Visceral Endoderm
     
     Yolk Sac (Extraembryonic Tissues)    fully expand to see all 3 entries
             Visceral Endoderm Cells Visceral Endoderm
     
     Epiblast (Early Embryonic Tissues)
             Early Epiblast Cells Epiblast
     
     Colon (Gastrointestinal Tract)
     
     Kidney (Urinary System)
    AMN Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    AMN Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.534494

    UniProtKB/Swiss-Prot: AMNLS_HUMAN, Q9BXJ7
    Tissue specificity: Long isoforms are highly expressed in small intestine, colon and kidney (renal proximal tubule
    epithelial cells). Shorter isoforms are detected at lower levels in testis, thymus and peripheral blood
    leukocytes

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for AMN gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Amn1 , 5 amnionless1, 5 72.56(n)1
    63.53(a)1
      12 (60.94 cM)5
    938351  NM_033603.21  NP_291081.21 
     1112711115 
    chicken
    (Gallus gallus)
    Aves AMN1 amnionless homolog (mouse) 57.55(n)
    44.68(a)
      423472  NM_001277516.1  NP_001264445.1 
    lizard
    (Anolis carolinensis)
    Reptilia AMN6
    amnion associated transmembrane protein
    35(a)
    1 ↔ 1
    GL343232.1(948852-1064864)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia amn1 amnion associated transmembrane protein 52.85(n)
    44.44(a)
      100485586  XM_002937997.2  XP_002938043.1 
    zebrafish
    (Danio rerio)
    Actinopterygii amn1 amnion associated transmembrane protein 52(n)
    41.06(a)
      793454  XM_002661272.3  XP_002661318.2 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG115926
    --
    16(a)
    1 ↔ 1
    2L(287252-289144)


    ENSEMBL Gene Tree for AMN (if available)
    TreeFam Gene Tree for AMN (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for AMN (see all 273)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 14 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs289393771,2,4
    Recessive hereditary megaloblastic anemia 1 (RH-MGA1)4--see VAR_0157332 mis40--------
    rs1156605891,2
    C,F--84378836(+) CCATCC/TACCAT 1 -- us2k11Minor allele frequency- T:0.07WA 118
    rs1398312891,2
    --84379087(+) CTATTC/TATCTT 1 -- us2k10--------
    rs1453645701,2
    --84379117(+) CTATCA/TTCCAC 1 -- us2k10--------
    rs762212441,2
    C,F--84379483(+) CAAACA/GTCCAC 1 -- us2k12Minor allele frequency- G:0.11WA NA 238
    rs1121180581,2
    C--84379502(+) CCCACT/-TTTTT 1 -- us2k11Minor allele frequency- -:0.50CSA 2
    rs49062741,2
    C,F,A--84379554(+) gcacaG/Atggcg 1 -- us2k18Minor allele frequency- A:0.28NA WA CSA EA 131
    rs1892378441,2
    --84379567(+) ATCTCC/TGATCA 1 -- us2k10--------
    rs1156990871,2
    F--84379580(+) ACAACC/TTCCGC 1 -- us2k11Minor allele frequency- T:0.01WA 118
    rs1431260631,2
    --84379735(+) CAGGTC/GATCTG 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for AMN (103388993 - 103399933 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for AMN:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv509552CNV Insertion20534489
    dgv1985n71CNV Loss21882294
    nsv902263CNV Loss21882294
    nsv9167CNV Gain18304495
    nsv483032CNV Gain15286789

    Human Gene Mutation Database (HGMD): AMN
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing AMN
    DNA2.0 Custom Variant and Variant Library Synthesis for AMN

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 605799   
    OMIM disorders: 261100  
    UniProtKB/Swiss-Prot: AMNLS_HUMAN, Q9BXJ7
  • Recessive hereditary megaloblastic anemia 1 (RH-MGA1) [MIM:261100]: Due to selective malabsorption of
    vitamin B12. Defects in vitamin B12 absorption lead to impaired function of thymidine synthase. As a consequence
    DNA synthesis is interrupted. Rapidly dividing cells involved in erythropoiesis are particularly affected.
    Note=The disease is caused by mutations affecting the gene represented in this entry

  • 17 diseases for AMN:    
    About MalaCards
    methylmalonic aciduria and homocystinuria type cble    adrenomyeloneuropathy, adult    megaloblastic anemia-1, norwegian type    methylmalonic aciduria and homocystinuria type cblg
    methylmalonic aciduria and homocystinuria type cbld    adrenoleukodystrophy    intrinsic factor deficiency    methylmalonic aciduria and homocystinuria type cblf
    megaloblastic anemia-1, finnish type    imerslund-grasbeck syndrome    methylmalonic aciduria and homocystinuria type cblc    cble
    cblg    cbld    megaloblastic anemia    cblf
    multiple carboxylase deficiency


    Find genes that share disorders with AMN           About GenesLikeMe


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    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for AMN gene, integrated from 10 sources (see all 26):
    (articles sorted by number of sources associating them with AMN)
        Utopia: connect your pdf to the dynamic
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    1. The amnionless gene, essential for mouse gastrulation, encodes a visceral-endoderm-specific protein with an extracellular cysteine-rich domain. (PubMed id 11279523)1, 2, 3 Kalantry S.... Lacy E. (Nat. Genet. 2001)
    2. Amnionless, essential for mouse gastrulation, is mutated in recessive hereditary megaloblastic anemia. (PubMed id 12590260)1, 2, 9 Tanner S.M.... de la Chapelle A. (Nat. Genet. 2003)
    3. The functional cobalamin (vitamin B12)-intrinsic factor receptor is a novel complex of cubilin and amnionless. (PubMed id 14576052)1, 2 Fyfe J.C.... Moestrup S.K. (Blood 2004)
    4. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (Genome Res. 2003)
    5. Variations of the Amnionless gene in recurrent spontaneous abortions. (PubMed id 16403802)1, 9 Kaare M....AittomAoki K. (Mol. Hum. Reprod. 2006)
    6. Imerslund-Grasbeck syndrome: new mutation in amnionless. (PubMed id 22631584)2 Densupsoontorn N.... Tanner S.M. (Pediatr. Int. 2012)
    7. Inherited cobalamin malabsorption. Mutations in three genes reveal functional and ethnic patterns. (PubMed id 22929189)1 Tanner S.M....de la Chapelle A. (Orphanet J Rare Dis 2012)
    8. Luminal expression of cubilin is impaired in Imerslund-Grasbeck syndrome with compound AMN mutations in intron 3 and exon 7. (PubMed id 21750092)1 Namour F....Gueant J.L. (Haematologica 2011)
    9. Ancient founder mutation is responsible for Imerslund-GrAosbeck Syndrome among diverse ethnicities. (PubMed id 22078000)1 Beech C.M....Tanner S.M. (Orphanet J Rare Dis 2011)
    10. Large-scale proteomics and phosphoproteomics of urinary exosomes. (PubMed id 19056867)1 Gonzales P.A....Knepper M.A. (J. Am. Soc. Nephrol. 2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 81693 HGNC: 14604 AceView: AMN Ensembl:ENSG00000166126 euGenes: HUgn81693
    ECgene: AMN H-InvDB: AMN

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for AMN Pharmacogenomics, SNPs, Pathways
    GeneReviewshttp://www.ncbi.nlm.nih.gov/books/NBK1116/?term=AMN[genesymbol]

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for AMN gene:
    Search GeneIP for patents involving AMN

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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