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AMMECR1L Gene

protein-coding   GIFtS: 44
GCID: GC02M128619

AMMECR1-Like

(Previous name: AMME chromosomal region gene 1-like)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
AMMECR1-like1 2
AMME Chromosomal Region Gene 1-Like1 2
AMMECR1-Like Protein2

External Ids:    HGNC: 286581   Entrez Gene: 836072   Ensembl: ENSG000001442337   UniProtKB: Q6DCA03   

Export aliases for AMMECR1L gene to outside databases

Previous GC identifers: GC02M128336 GC02M120925


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for AMMECR1L Gene:
AMMECR1L (AMMECR1-like) is a protein-coding gene. An important paralog of this gene is AMMECR1.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000002.11  NT_005403.18  NC_018913.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the AMMECR1L gene promoter:
         Pax-5   AML1a   Egr-1   LUN-1   Tal-1beta   E47   Egr-4   PPAR-alpha   POU2F1a   Cart-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidAMMECR1L promoter sequence
   Search Chromatin IP Primers for AMMECR1L

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat AMMECR1L


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q21   Ensembl cytogenetic band:  2q14.3   HGNC cytogenetic band: 2q21

AMMECR1L Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
AMMECR1L gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02M128619:  view genomic region     (about GC identifiers)

Start:
128,619,204 bp from pter      End:
128,643,514 bp from pter
Size:
24,311 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: AMERL_HUMAN, Q6DCA0 (See protein sequence)
Recommended Name: AMMECR1-like protein  
Size: 310 amino acids; 34499 Da
Secondary accessions: B4E276

Explore the universe of human proteins at neXtProt for AMMECR1L: NX_Q6DCA0

Explore proteomics data for AMMECR1L at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See AMMECR1L Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001186069.1  NP_113633.2  

    ENSEMBL proteins: 
     ENSP00000272647   ENSP00000376726  

    AMMECR1L Human Recombinant Protein Products:

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    antibodies-online proteins for AMMECR1L (2 products) 

     
    antibodies-online peptides for AMMECR1L

    AMMECR1L Antibody Products:

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    Cloud-Clone Corp. CLIAs for AMMECR1L
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    antibodies-online kits for AMMECR1L (4 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    3 InterPro protein domains:
     IPR027485 AMMECR1_N
     IPR023473 AMMECR1
     IPR002733 AMMECR1_domain

    Graphical View of Domain Structure for InterPro Entry Q6DCA0

    ProtoNet protein and cluster: Q6DCA0

    UniProtKB/Swiss-Prot: AMERL_HUMAN, Q6DCA0
    Similarity: Contains 1 AMMECR1 domain


    Find genes that share domains with AMMECR1L           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Phenotypes:
         2 GenomeRNAi human phenotypes for AMMECR1L:
     G0/1 arrest  Increased G1 DNA content 

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for AMMECR1L

    miRNA
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    miRTarBase miRNAs that target AMMECR1L:
    hsa-mir-10a-5p (MIRT047569), hsa-mir-423-3p (MIRT042613), hsa-mir-484 (MIRT041681), hsa-mir-15b-5p (MIRT046528), hsa-mir-221-3p (MIRT046855), hsa-mir-877-3p (MIRT036891), hsa-mir-101-3p (MIRT027316)

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    Selected qRT-PCR Assays for microRNAs that regulate AMMECR1L (see all 58):
    hsa-miR-4291 hsa-miR-582-3p hsa-let-7d hsa-miR-15a hsa-miR-128 hsa-miR-1245 hsa-miR-29a hsa-miR-374c
    Browse SwitchGear 3'UTR luciferase reporter plasmids
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    Predesigned siRNA for gene silencing in human, mouse, rat AMMECR1L

    Gene Editing
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol2
    nucleus2
    extracellular1
    peroxisome1

    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for AMMECR1L
    Interactions:

        Search GeneGlobe Interaction Network for AMMECR1L

    STRING Interaction Network Preview (showing 5 interactants - click image to see 7)

    Selected Interacting proteins for AMMECR1L (Q6DCA03 ENSP000002726474) via UniProtKB, MINT, STRING, and/or I2D (see all 8)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    IKBKGQ9Y6K93, ENSP000003586224I2D: score=1 STRING: ENSP00000358622
    EIF6P565373, ENSP000003635594I2D: score=1 STRING: ENSP00000363559
    PPP1CCP368733I2D: score=1 
    ST13ENSP000002162184STRING: ENSP00000216218
    ELAVL1ENSP000003852694STRING: ENSP00000385269
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for AMMECR1L (AMERL)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for AMMECR1L gene (2 alternative transcripts): 
    NM_001199140.1  NM_031445.2  

    Unigene Cluster for AMMECR1L:

    AMMECR1-like
    Hs.546449  [show with all ESTs]
    Unigene Representative Sequence: BC016181
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000272647(uc002tpm.3) ENST00000393001(uc002tpl.3)
    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate AMMECR1L (see all 58):
    hsa-miR-4291 hsa-miR-582-3p hsa-let-7d hsa-miR-15a hsa-miR-128 hsa-miR-1245 hsa-miR-29a hsa-miR-374c
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    OriGene qPCR primer pairs and template standards for AMMECR1L
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat AMMECR1L
      QuantiTect SYBR Green Assays in human, mouse, rat AMMECR1L
      QuantiFast Probe-based Assays in human, mouse, rat AMMECR1L

    Additional mRNA sequence: 

    AK024993.1 AK026685.1 AK095871.1 AK304145.1 AL137415.1 BC004208.2 BC016181.1 BC067124.1 
    BC078174.1 BC084552.1 

    8 DOTS entries:

    DT.215244  DT.97840684  DT.75122036  DT.92044854  DT.102836753  DT.120990337  DT.120990350  DT.99933633 

    Selected AceView cDNA sequences (see all 142):

    AK095871 BU074640 BC078174 AL045777 CB529887 AA232556 AW026965 AI479394 
    CK906072 AI382845 BX384639 AI678819 W92050 CA427426 BQ879524 BU177246 
    BI857322 R44848 AA829394 BC016181 CD367962 CA429828 AA777169 CK000706 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for AMMECR1L    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10a · 10b
    SP1:        -                                               -                     
    SP2:                                                        -                     
    SP3:                                                                              
    SP4:                                      -                                       


    ECgene alternative splicing isoforms for AMMECR1L

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    AMMECR1L expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    AMMECR1L Expression
    About this image

    AMMECR1L Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    AMMECR1L Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.546449
        Custom PCR Arrays for AMMECR1L
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for AMMECR1L

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for AMMECR1L gene from Selected species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ammecr1l1 , 5 AMME chromosomal region gene 1-like1, 5 94.3(n)1
    98.39(a)1
      18 (17.84 cM)5
    2253391  NM_001242430.11  NP_001229359.11 
     317598245 
    chicken
    (Gallus gallus)
    Aves AMMECR1L1 AMME chromosomal region gene 1-like 88.39(n)
    96.13(a)
      424755  XM_422577.3  XP_422577.2 
    lizard
    (Anolis carolinensis)
    Reptilia AMMECR1L6
    AMMECR1-like
    95(a)
    1 ↔ 1
    3(36342401-36368652)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia ammecr1l1 AMMECR1-like 74.34(n)
    80.22(a)
      100158611  XM_002936606.2  XP_002936652.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.132022 Transcribed sequence 96.15(n)    BI884289.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG59026
    --
    55(a)
    1 → many
    3R(19812362-19814460)
    worm
    (Caenorhabditis elegans)
    Secernentea R166.36
    Protein R166.3 (R166.3) mRNA, complete cds
    43(a)
    1 → many
    II(10537799-10539332) WBGene00011303
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes --
    Putative protein of unknown function; transcriptio...
    27(a)
    1 → many
    XV(853357-854112) YOR289W


    ENSEMBL Gene Tree for AMMECR1L (if available)
    TreeFam Gene Tree for AMMECR1L (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for AMMECR1L gene
    AMMECR12  
    1 SIMAP similar gene for AMMECR1L using alignment to 1 protein entry:     AMERL_HUMAN:
    AMMECR1

    Find genes that share paralogs with AMMECR1L           About GenesLikeMe


    1 Pseudogenes.org Pseudogene for AMMECR1L
    PGOHUM00000248667


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for AMMECR1L (see all 543)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs559826201,2
    C--120950569(+) GCGGAA/GTACCT 1 -- us2k10--------
    rs1489757161,2
    --120950623(+) GCTCTA/GGCAGT 1 -- us2k10--------
    rs1133263121,2
    C,F--120950706(+) TACTGG/ATTTTT 1 -- us2k11Minor allele frequency- A:0.50NA 2
    rs576255381,2
    C--128618725(+) AAAAA-/A/AA  
            
    GCGTA
    2 -- int11NA 2
    rs1863529711,2
    --128618727(+) AAAAGC/TGTAAA 2 -- int10--------
    rs560273371,2
    C,F--128618955(+) AACGAA/GCCTGT 2 -- int13Minor allele frequency- G:0.07WA CSA 122
    rs602359801,2
    C,F--128619123(+) CCTGTC/TTTCAA 2 -- int15Minor allele frequency- T:0.19WA CSA EA 244
    rs1498442661,2
    C--128619240(+) ACTTCA/GTTAAA 2 -- ut310--------
    rs1458544311,2
    --128619277(+) TATATA/GGCCAA 2 -- ut310--------
    rs116816851,2
    C,H--128619278(+) ATATAG/TCCAAG 2 -- ut311Minor allele frequency- T:0.00NA 2

    HapMap Linkage Disequilibrium report for AMMECR1L (128619204 - 128643514 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for AMMECR1L:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv268180CNV Insertion20981092
    esv272652CNV Insertion20981092
    nsv834367CNV Loss17160897

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing AMMECR1L
    DNA2.0 Custom Variant and Variant Library Synthesis for AMMECR1L

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    Find genes that share disorders with AMMECR1L           About GenesLikeMe

    Genetic Association Database (GAD): AMMECR1L

    Export disorders for AMMECR1L gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for AMMECR1L gene, integrated from 10 sources (see all 13):
    (articles sorted by number of sources associating them with AMMECR1L)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    3. The protein interaction landscape of the human CMGC kinase group. (PubMed id 23602568)1 Varjosalo M....Gstaiger M. (Cell Rep 2013)
    4. Biochemical and computational analysis of LNX1 interacting proteins. (PubMed id 22087225)1 Wolting C.D....McGlade C.J. (PLoS ONE 2011)
    5. Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (amp 2011)
    6. Expanding the substantial interactome of NEMO using protein microarrays. (PubMed id 20098747)1 Fenner B.J....Prehn J.H. (PLoS ONE 2010)
    7. Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. (PubMed id 19690332)2 Mayya V.... Han D.K. (Sci. Signal. 2009)
    8. Ubiquitin-mediated proteolysis of HuR by heat shock. (PubMed id 19322201)1 Abdelmohsen K....Gorospe M. (EMBO J. 2009)
    9. A quantitative atlas of mitotic phosphorylation. (PubMed id 18669648)2 Dephoure N.... Gygi S.P. (Proc. Natl. Acad. Sci. U.S.A. 2008)
    10. A genome-wide association study for blood lipid phenotypes in the Framingham Heart Study. (PubMed id 17903299)4 Kathiresan S....Cupples L.A. (BMC Med. Genet. 2007)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 83607 HGNC: 28658 AceView: MGC4268 Ensembl:ENSG00000144233 euGenes: HUgn83607
    ECgene: AMMECR1L H-InvDB: AMMECR1L

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for AMMECR1L Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for AMMECR1L gene:
    Search GeneIP for patents involving AMMECR1L

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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