Free for academic non-profit institutions. Other users need a Commercial license

Aliases for AMIGO3 Gene

Aliases for AMIGO3 Gene

  • Adhesion Molecule With Ig Like Domain 3 2 3 5
  • Alivin-3 3 4
  • AMIGO-3 3 4
  • ALI3 3 4
  • Amphoterin-Induced Gene And Open Reading Frame 3 2
  • Amphoterin-Induced Gene And ORF 3 3
  • Amphoterin-Induced Protein 3 3
  • KIAA1851 4

External Ids for AMIGO3 Gene

Previous GeneCards Identifiers for AMIGO3 Gene

  • GC03U900475
  • GC03M049713
  • GC03M049729
  • GC03M049755

Summaries for AMIGO3 Gene

GeneCards Summary for AMIGO3 Gene

AMIGO3 (Adhesion Molecule With Ig Like Domain 3) is a Protein Coding gene. An important paralog of this gene is AMIGO1.

UniProtKB/Swiss-Prot for AMIGO3 Gene

  • May mediate heterophilic cell-cell interaction. May contribute to signal transduction through its intracellular domain (By similarity).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for AMIGO3 Gene

Genomics for AMIGO3 Gene

Regulatory Elements for AMIGO3 Gene

Enhancers for AMIGO3 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH03F049694 0.5 ENCODE 13.3 +24.6 24570 1.3 ZNF664 ZFHX2 PKNOX1 EGR2 WDR6 AMIGO3 GMPPB APEH BSN-AS1 BSN AMT C3orf18 MST1
GH03F049686 0.2 ENCODE 12.6 +31.5 31458 4.2 HDGF PKNOX1 ARNT MLX CREB3L1 ARID4B SIN3A DMAP1 ZNF2 YY1 AMT CDHR4 AMIGO3 GMPPB PHF5EP IP6K1 MST1 APEH RBM6 PIR39139
GH03F049747 0.2 ENCODE 12.1 -28.6 -28594 1.9 HDGF PKNOX1 MLX ARID4B SIN3A DMAP1 YY1 ZNF143 ZNF207 FOS FAM212A PHF5EP IP6K1 QRICH1 GMPPB AMIGO3 RNF123 ENSG00000225399 IMPDH2 BSN-AS1
GH03F049443 0.5 Ensembl ENCODE 9.9 +274.7 274671 3.9 HDGF TBL1XR1 THRB GTF3C2 ELK1 ETV6 FOS CREM NCOA1 JUNB AMT QRICH1 TMEM115 SEMA3F-AS1 RHOA-IT1 WDR6 CCDC71 TMEM89 GMPPB IMPDH2
GH03F049428 0.4 ENCODE 9.9 +290.3 290305 1.8 PKNOX1 CREB3L1 MLX ARID4B SIN3A YBX1 DMAP1 ZNF2 YY1 ZNF766 AMT TMEM115 QRICH1 LAMB2 CCDC71 IMPDH2 NICN1 WDR6 RHOA-IT1 SEMA3F-AS1
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around AMIGO3 on UCSC Golden Path with GeneCards custom track

Promoters for AMIGO3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001847749 305 1001 HDGF TBP CTCF MAX RAD21 CCNT2 POLR2A NFYB ZNF143 SMC3

Genomic Location for AMIGO3 Gene

Chromosome:
3
Start:
49,716,834 bp from pter
End:
49,719,805 bp from pter
Size:
2,972 bases
Orientation:
Minus strand

Genomic View for AMIGO3 Gene

Genes around AMIGO3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
AMIGO3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for AMIGO3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for AMIGO3 Gene

Proteins for AMIGO3 Gene

  • Protein details for AMIGO3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q86WK7-AMGO3_HUMAN
    Recommended name:
    Amphoterin-induced protein 3
    Protein Accession:
    Q86WK7
    Secondary Accessions:
    • Q494V6
    • Q96JH6

    Protein attributes for AMIGO3 Gene

    Size:
    504 amino acids
    Molecular mass:
    55250 Da
    Quaternary structure:
    • Binds AMIGO1 or AMIGO2.
    SequenceCaution:
    • Sequence=BAB47480.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for AMIGO3 Gene

Post-translational modifications for AMIGO3 Gene

  • Glycosylation at Asn 107, Asn 272, Asn 301, Asn 362, and Asn 368
  • Modification sites at PhosphoSitePlus

Other Protein References for AMIGO3 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Abcam antibodies for AMIGO3
  • Santa Cruz Biotechnology (SCBT) Antibodies for AMIGO3

No data available for DME Specific Peptides for AMIGO3 Gene

Domains & Families for AMIGO3 Gene

Gene Families for AMIGO3 Gene

Suggested Antigen Peptide Sequences for AMIGO3 Gene

Graphical View of Domain Structure for InterPro Entry

Q86WK7

UniProtKB/Swiss-Prot:

AMGO3_HUMAN :
  • Contains 1 Ig-like C2-type (immunoglobulin-like) domain.
  • Belongs to the immunoglobulin superfamily. AMIGO family.
  • Contains 6 LRR (leucine-rich) repeats.
Domain:
  • Contains 1 Ig-like C2-type (immunoglobulin-like) domain.
  • Contains 1 LRRCT domain.
  • Contains 1 LRRNT domain.
Family:
  • Belongs to the immunoglobulin superfamily. AMIGO family.
Similarity:
  • Contains 6 LRR (leucine-rich) repeats.
genes like me logo Genes that share domains with AMIGO3: view

Function for AMIGO3 Gene

Molecular function for AMIGO3 Gene

UniProtKB/Swiss-Prot Function:
May mediate heterophilic cell-cell interaction. May contribute to signal transduction through its intracellular domain (By similarity).
genes like me logo Genes that share phenotypes with AMIGO3: view

Animal Models for AMIGO3 Gene

MGI Knock Outs for AMIGO3:

Animal Model Products

  • Taconic Biosciences Mouse Models for AMIGO3

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for AMIGO3 Gene

Localization for AMIGO3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for AMIGO3 Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for AMIGO3 Gene COMPARTMENTS Subcellular localization image for AMIGO3 gene
Compartment Confidence
plasma membrane 3
cytoskeleton 2
extracellular 2
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for AMIGO3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with AMIGO3: view

Pathways & Interactions for AMIGO3 Gene

SuperPathways for AMIGO3 Gene

No Data Available

Interacting Proteins for AMIGO3 Gene

Gene Ontology (GO) - Biological Process for AMIGO3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007157 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules ISS 12629050
GO:0051965 positive regulation of synapse assembly IEA --
genes like me logo Genes that share ontologies with AMIGO3: view

No data available for Pathways by source and SIGNOR curated interactions for AMIGO3 Gene

Transcripts for AMIGO3 Gene

mRNA/cDNA for AMIGO3 Gene

(1) REFSEQ mRNAs :
(6) Additional mRNA sequences :
(185) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for AMIGO3 Gene

Adhesion molecule with Ig-like domain 3:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for AMIGO3 Gene

No ASD Table

Relevant External Links for AMIGO3 Gene

GeneLoc Exon Structure for
AMIGO3
ECgene alternative splicing isoforms for
AMIGO3

Expression for AMIGO3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for AMIGO3 Gene

NURSA nuclear receptor signaling pathways regulating expression of AMIGO3 Gene:

AMIGO3

SOURCE GeneReport for Unigene cluster for AMIGO3 Gene:

Hs.567903
genes like me logo Genes that share expression patterns with AMIGO3: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for AMIGO3 Gene

Orthologs for AMIGO3 Gene

This gene was present in the common ancestor of chordates.

Orthologs for AMIGO3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia AMIGO3 35
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia AMIGO3 34 35
  • 83.4 (n)
cow
(Bos Taurus)
Mammalia AMIGO3 34 35
  • 82.34 (n)
rat
(Rattus norvegicus)
Mammalia Amigo3 34
  • 78.84 (n)
mouse
(Mus musculus)
Mammalia Amigo3 34 16 35
  • 78 (n)
oppossum
(Monodelphis domestica)
Mammalia AMIGO3 35
  • 57 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia AMIGO3 35
  • 51 (a)
OneToOne
chicken
(Gallus gallus)
Aves AMIGO3 34 35
  • 63.31 (n)
lizard
(Anolis carolinensis)
Reptilia AMIGO3 35
  • 39 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia amigo3 34
  • 51.83 (n)
zebrafish
(Danio rerio)
Actinopterygii amigo3 34 35
  • 51.21 (n)
CR385022.1 35
  • 36 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 23 (a)
OneToMany
Species where no ortholog for AMIGO3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for AMIGO3 Gene

ENSEMBL:
Gene Tree for AMIGO3 (if available)
TreeFam:
Gene Tree for AMIGO3 (if available)

Paralogs for AMIGO3 Gene

Paralogs for AMIGO3 Gene

(4) SIMAP similar genes for AMIGO3 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with AMIGO3: view

Variants for AMIGO3 Gene

Sequence variations from dbSNP and Humsavar for AMIGO3 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs1046598 -- 49,721,611(-) GCCTT(C/T)TCATG downstream-variant-500B, upstream-variant-2KB, utr-variant-3-prime
rs10632591 -- 49,720,160(+) AACAA(-/CAA)TTAGC intron-variant, upstream-variant-2KB
rs112205092 -- 49,716,759(+) GACTC(C/T)GGAGG intron-variant
rs112572467 -- 49,720,455(+) AAGAG(A/G)GACTT intron-variant, upstream-variant-2KB
rs114836451 -- 49,721,684(+) CTTCT(A/G)ATGTG downstream-variant-500B, upstream-variant-2KB, utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for AMIGO3 Gene

Variant ID Type Subtype PubMed ID
nsv482082 CNV gain 20164927
nsv508217 CNV deletion 20534489

Variation tolerance for AMIGO3 Gene

Residual Variation Intolerance Score: 12.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.86; 34.82% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for AMIGO3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
AMIGO3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for AMIGO3 Gene

Disorders for AMIGO3 Gene

Relevant External Links for AMIGO3

Genetic Association Database (GAD)
AMIGO3
Human Genome Epidemiology (HuGE) Navigator
AMIGO3
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
AMIGO3

No disorders were found for AMIGO3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for AMIGO3 Gene

Publications for AMIGO3 Gene

  1. AMIGO, a transmembrane protein implicated in axon tract development, defines a novel protein family with leucine-rich repeats. (PMID: 12629050) Kuja-Panula J. … Rauvala H. (J. Cell Biol. 2003) 2 3 4 64
  2. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 2 3 4 64
  3. Association analysis of 3p21 with Crohn's disease in a New Zealand population. (PMID: 20307617) Morgan A.R. … Ferguson L.R. (Hum. Immunol. 2010) 3 46 64
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  5. Prediction of the coding sequences of unidentified human genes. XX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 11347906) Nagase T. … Ohara O. (DNA Res. 2001) 3 4 64

Products for AMIGO3 Gene

Sources for AMIGO3 Gene

Content
Loading form....