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Aliases for AMIGO3 Gene

Aliases for AMIGO3 Gene

  • Adhesion Molecule With Ig-Like Domain 3 2 3 5
  • Alivin-3 3 4
  • AMIGO-3 3 4
  • ALI3 3 4
  • Amphoterin-Induced Gene And Open Reading Frame 3 2
  • Amphoterin-Induced Gene And ORF 3 3
  • KIAA1851 4

External Ids for AMIGO3 Gene

Previous GeneCards Identifiers for AMIGO3 Gene

  • GC03U900475
  • GC03M049713
  • GC03M049729
  • GC03M049755

Summaries for AMIGO3 Gene

GeneCards Summary for AMIGO3 Gene

AMIGO3 (Adhesion Molecule With Ig-Like Domain 3) is a Protein Coding gene. Diseases associated with AMIGO3 include muscular dystrophy-dystroglycanopathy , type a, 14 and muscular dystrophy-dystroglycanopathy , type c, 14. An important paralog of this gene is AMIGO2.

UniProtKB/Swiss-Prot for AMIGO3 Gene

  • May mediate heterophilic cell-cell interaction. May contribute to signal transduction through its intracellular domain (By similarity).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for AMIGO3 Gene

Genomics for AMIGO3 Gene

Regulatory Elements for AMIGO3 Gene

Promoters for AMIGO3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around AMIGO3 on UCSC Golden Path with GeneCards custom track

Genomic Location for AMIGO3 Gene

Chromosome:
3
Start:
49,716,834 bp from pter
End:
49,719,805 bp from pter
Size:
2,972 bases
Orientation:
Minus strand

Genomic View for AMIGO3 Gene

Genes around AMIGO3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
AMIGO3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for AMIGO3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for AMIGO3 Gene

Proteins for AMIGO3 Gene

  • Protein details for AMIGO3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q86WK7-AMGO3_HUMAN
    Recommended name:
    Amphoterin-induced protein 3
    Protein Accession:
    Q86WK7
    Secondary Accessions:
    • Q494V6
    • Q96JH6

    Protein attributes for AMIGO3 Gene

    Size:
    504 amino acids
    Molecular mass:
    55250 Da
    Quaternary structure:
    • Binds AMIGO1 or AMIGO2.
    SequenceCaution:
    • Sequence=BAB47480.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for AMIGO3 Gene

Proteomics data for AMIGO3 Gene at MOPED

Post-translational modifications for AMIGO3 Gene

  • Glycosylation at Asn 107, Asn 272, Asn 301, Asn 362, and Asn 368
  • Modification sites at PhosphoSitePlus

Other Protein References for AMIGO3 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for AMIGO3 Gene

Domains & Families for AMIGO3 Gene

Gene Families for AMIGO3 Gene

Suggested Antigen Peptide Sequences for AMIGO3 Gene

Graphical View of Domain Structure for InterPro Entry

Q86WK7

UniProtKB/Swiss-Prot:

AMGO3_HUMAN :
  • Contains 1 Ig-like C2-type (immunoglobulin-like) domain.
  • Belongs to the immunoglobulin superfamily. AMIGO family.
  • Contains 6 LRR (leucine-rich) repeats.
Domain:
  • Contains 1 Ig-like C2-type (immunoglobulin-like) domain.
  • Contains 1 LRRCT domain.
  • Contains 1 LRRNT domain.
Family:
  • Belongs to the immunoglobulin superfamily. AMIGO family.
Similarity:
  • Contains 6 LRR (leucine-rich) repeats.
genes like me logo Genes that share domains with AMIGO3: view

Function for AMIGO3 Gene

Molecular function for AMIGO3 Gene

UniProtKB/Swiss-Prot Function:
May mediate heterophilic cell-cell interaction. May contribute to signal transduction through its intracellular domain (By similarity).
genes like me logo Genes that share phenotypes with AMIGO3: view

Animal Model Products

  • Taconic Biosciences Mouse Models for AMIGO3

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for AMIGO3 Gene

Localization for AMIGO3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for AMIGO3 Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for AMIGO3 Gene COMPARTMENTS Subcellular localization image for AMIGO3 gene
Compartment Confidence
plasma membrane 3
cytoskeleton 2
extracellular 2
endoplasmic reticulum 1

No data available for Gene Ontology (GO) - Cellular Components for AMIGO3 Gene

Pathways & Interactions for AMIGO3 Gene

SuperPathways for AMIGO3 Gene

No Data Available

Interacting Proteins for AMIGO3 Gene

Gene Ontology (GO) - Biological Process for AMIGO3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0051965 positive regulation of synapse assembly IEA --
genes like me logo Genes that share ontologies with AMIGO3: view

No data available for Pathways by source and SIGNOR curated interactions for AMIGO3 Gene

Drugs & Compounds for AMIGO3 Gene

No Compound Related Data Available

Transcripts for AMIGO3 Gene

mRNA/cDNA for AMIGO3 Gene

(1) REFSEQ mRNAs :
(6) Additional mRNA sequences :
(185) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for AMIGO3 Gene

Adhesion molecule with Ig-like domain 3:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for AMIGO3 Gene

No ASD Table

Relevant External Links for AMIGO3 Gene

GeneLoc Exon Structure for
AMIGO3
ECgene alternative splicing isoforms for
AMIGO3

Expression for AMIGO3 Gene

mRNA expression in normal human tissues for AMIGO3 Gene

SOURCE GeneReport for Unigene cluster for AMIGO3 Gene Hs.567903

genes like me logo Genes that share expression patterns with AMIGO3: view

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for AMIGO3 Gene

Orthologs for AMIGO3 Gene

This gene was present in the common ancestor of chordates.

Orthologs for AMIGO3 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia AMIGO3 35
  • 82.34 (n)
  • 80.36 (a)
AMIGO3 36
  • 79 (a)
OneToOne
dog
(Canis familiaris)
Mammalia AMIGO3 35
  • 83.4 (n)
  • 83.33 (a)
AMIGO3 36
  • 81 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Amigo3 35
  • 78 (n)
  • 77.2 (a)
Amigo3 16
Amigo3 36
  • 76 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Amigo3 35
  • 78.84 (n)
  • 78.97 (a)
oppossum
(Monodelphis domestica)
Mammalia AMIGO3 36
  • 57 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia AMIGO3 36
  • 51 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia AMIGO3 36
  • 99 (a)
OneToOne
chicken
(Gallus gallus)
Aves AMIGO3 35
  • 63.31 (n)
  • 50.73 (a)
AMIGO3 36
  • 45 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia AMIGO3 36
  • 39 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia amigo3 35
  • 51.83 (n)
  • 46.05 (a)
zebrafish
(Danio rerio)
Actinopterygii amigo3 35
  • 51.21 (n)
  • 44.59 (a)
amigo3 36
  • 41 (a)
OneToMany
CR385022.1 36
  • 36 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 23 (a)
OneToMany
Species with no ortholog for AMIGO3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for AMIGO3 Gene

ENSEMBL:
Gene Tree for AMIGO3 (if available)
TreeFam:
Gene Tree for AMIGO3 (if available)

Paralogs for AMIGO3 Gene

Paralogs for AMIGO3 Gene

(4) SIMAP similar genes for AMIGO3 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with AMIGO3: view

Variants for AMIGO3 Gene

Structural Variations from Database of Genomic Variants (DGV) for AMIGO3 Gene

Variant ID Type Subtype PubMed ID
nsv508217 CNV Loss 20534489
nsv482082 CNV Gain 20164927

Variation tolerance for AMIGO3 Gene

Residual Variation Intolerance Score: 12.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.86; 34.82% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for AMIGO3 Gene

HapMap Linkage Disequilibrium report
AMIGO3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations from dbSNP and Humsavar for AMIGO3 Gene

Disorders for AMIGO3 Gene

MalaCards: The human disease database

(3) MalaCards diseases for AMIGO3 Gene - From: OMIM

Disorder Aliases PubMed IDs
muscular dystrophy-dystroglycanopathy , type a, 14
  • muscular dystrophy-dystroglycanopathy congenital with brain and eye anomalies a14
muscular dystrophy-dystroglycanopathy , type c, 14
  • limb-girdle muscular dystrophy type 2t
muscular dystrophy-dystroglycanopathy , type b, 14
  • muscular dystrophy-dystroglycanopathy congenital with mental retardation b14
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for AMIGO3

Genetic Association Database (GAD)
AMIGO3
Human Genome Epidemiology (HuGE) Navigator
AMIGO3
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
AMIGO3
genes like me logo Genes that share disorders with AMIGO3: view

No data available for UniProtKB/Swiss-Prot and Genatlas for AMIGO3 Gene

Publications for AMIGO3 Gene

  1. AMIGO, a transmembrane protein implicated in axon tract development, defines a novel protein family with leucine-rich repeats. (PMID: 12629050) Kuja-Panula J. … Rauvala H. (J. Cell Biol. 2003) 2 3 4 67
  2. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 2 3
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  4. Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47. (PMID: 21297633) Anderson C.A. … Rioux J.D. (Nat. Genet. 2011) 3
  5. Association analysis of 3p21 with Crohn's disease in a New Zealand population. (PMID: 20307617) Morgan A.R. … Ferguson L.R. (Hum. Immunol. 2010) 3

Products for AMIGO3 Gene

Sources for AMIGO3 Gene

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