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Aliases for AMIGO3 Gene

Aliases for AMIGO3 Gene

  • Adhesion Molecule With Ig-Like Domain 3 2 3
  • ALI3 3 4 6
  • Alivin-3 3 4
  • AMIGO-3 3 4
  • Amphoterin-Induced Gene And Open Reading Frame 3 2
  • Amphoterin-Induced Gene And ORF 3 3
  • Amphoterin-Induced Protein 3 3
  • KIAA1851 4

External Ids for AMIGO3 Gene

Previous GeneCards Identifiers for AMIGO3 Gene

  • GC03U900475
  • GC03M049713
  • GC03M049729
  • GC03M049755

Summaries for AMIGO3 Gene

GeneCards Summary for AMIGO3 Gene

AMIGO3 (Adhesion Molecule With Ig-Like Domain 3) is a Protein Coding gene. Diseases associated with AMIGO3 include ulcerative colitis. An important paralog of this gene is AMIGO2.

UniProtKB/Swiss-Prot for AMIGO3 Gene

  • May mediate heterophilic cell-cell interaction. May contribute to signal transduction through its intracellular domain (By similarity).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for AMIGO3 Gene

Genomics for AMIGO3 Gene

Regulatory Elements for AMIGO3 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for AMIGO3 Gene

49,716,834 bp from pter
49,719,805 bp from pter
2,972 bases
Minus strand

Genomic View for AMIGO3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for AMIGO3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for AMIGO3 Gene

Proteins for AMIGO3 Gene

  • Protein details for AMIGO3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Amphoterin-induced protein 3
    Protein Accession:
    Secondary Accessions:
    • Q494V6
    • Q96JH6

    Protein attributes for AMIGO3 Gene

    504 amino acids
    Molecular mass:
    55250 Da
    Quaternary structure:
    • Binds AMIGO1 or AMIGO2.
    • Sequence=BAB47480.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for AMIGO3 Gene

Proteomics data for AMIGO3 Gene at MOPED

Post-translational modifications for AMIGO3 Gene

  • Glycosylation at Asn107, Asn272, Asn301, Asn362, and Asn368
  • Modification sites at PhosphoSitePlus

Other Protein References for AMIGO3 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for AMIGO3 Gene

Domains for AMIGO3 Gene

Gene Families for AMIGO3 Gene

  • IGD :Immunoglobulin superfamily / Immunoglobulin-like domain containing

Suggested Antigen Peptide Sequences for AMIGO3 Gene

Graphical View of Domain Structure for InterPro Entry



  • Q86WK7
  • Contains 1 Ig-like C2-type (immunoglobulin-like) domain.
  • Contains 1 LRRCT domain.
  • Contains 1 LRRNT domain.
  • Belongs to the immunoglobulin superfamily. AMIGO family.
  • Contains 6 LRR (leucine-rich) repeats.
genes like me logo Genes that share domains with AMIGO3: view

Function for AMIGO3 Gene

Molecular function for AMIGO3 Gene

UniProtKB/Swiss-Prot Function:
May mediate heterophilic cell-cell interaction. May contribute to signal transduction through its intracellular domain (By similarity).

Gene Ontology (GO) - Molecular Function for AMIGO3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with AMIGO3: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for AMIGO3 Gene

Localization for AMIGO3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for AMIGO3 Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

Jensen Localization Image for AMIGO3 Gene COMPARTMENTS Subcellular localization image for AMIGO3 gene
Compartment Confidence
plasma membrane 3
extracellular 2
cytoskeleton 1
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for AMIGO3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IBA --
genes like me logo Genes that share ontologies with AMIGO3: view

Pathways for AMIGO3 Gene

SuperPathways for AMIGO3 Gene

No Data Available

Interacting Proteins for AMIGO3 Gene

Gene Ontology (GO) - Biological Process for AMIGO3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007157 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules ISS 12629050
GO:0007420 brain development IBA --
GO:0098609 cell-cell adhesion IBA --
genes like me logo Genes that share ontologies with AMIGO3: view

No data available for Pathways by source for AMIGO3 Gene

Transcripts for AMIGO3 Gene

mRNA/cDNA for AMIGO3 Gene

(185) Selected AceView cDNA sequences:
(6) Additional mRNA sequences :
(1) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for AMIGO3 Gene

Adhesion molecule with Ig-like domain 3:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for AMIGO3

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for AMIGO3 Gene

No ASD Table

Relevant External Links for AMIGO3 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for AMIGO3 Gene

mRNA expression in normal human tissues for AMIGO3 Gene

SOURCE GeneReport for Unigene cluster for AMIGO3 Gene Hs.567903

genes like me logo Genes that share expressions with AMIGO3: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Expression partners for AMIGO3 Gene

Orthologs for AMIGO3 Gene

This gene was present in the common ancestor of chordates.

Orthologs for AMIGO3 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia AMIGO3 35
  • 82.34 (n)
  • 80.36 (a)
  • 79 (a)
(Canis familiaris)
Mammalia AMIGO3 35
  • 83.4 (n)
  • 83.33 (a)
  • 81 (a)
(Mus musculus)
Mammalia Amigo3 35
  • 78 (n)
  • 77.2 (a)
Amigo3 16
Amigo3 36
  • 76 (a)
(Rattus norvegicus)
Mammalia Amigo3 35
  • 78.84 (n)
  • 78.97 (a)
(Monodelphis domestica)
Mammalia AMIGO3 36
  • 57 (a)
(Ornithorhynchus anatinus)
Mammalia AMIGO3 36
  • 51 (a)
(Pan troglodytes)
Mammalia AMIGO3 36
  • 99 (a)
(Gallus gallus)
Aves AMIGO3 35
  • 63.31 (n)
  • 50.73 (a)
  • 45 (a)
(Anolis carolinensis)
Reptilia AMIGO3 36
  • 39 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia amigo3 35
  • 51.83 (n)
  • 46.05 (a)
(Danio rerio)
Actinopterygii amigo3 35
  • 51.21 (n)
  • 44.59 (a)
amigo3 36
  • 41 (a)
CR385022.1 36
  • 36 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 23 (a)
Species with no ortholog for AMIGO3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for AMIGO3 Gene

Gene Tree for AMIGO3 (if available)
Gene Tree for AMIGO3 (if available)

Paralogs for AMIGO3 Gene

Paralogs for AMIGO3 Gene

Selected SIMAP similar genes for AMIGO3 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with AMIGO3: view

Variants for AMIGO3 Gene

Sequence variations from dbSNP and Humsavar for AMIGO3 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type MAF
rs11539664 -- 49,716,177(-) TAGGC(A/C)AGGCA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for AMIGO3 Gene

Variant ID Type Subtype PubMed ID
nsv508217 CNV Loss 20534489
nsv482082 CNV Gain 20164927

Relevant External Links for AMIGO3 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for AMIGO3 Gene

Disorders for AMIGO3 Gene

MalaCards: The human disease database

MalaCards: The human disease database.

Search for AMIGO3 Gene in MalaCards »

(1) Diseases for AMIGO3 Gene including...

Relevant External Links for AMIGO3

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with AMIGO3: view

No data available for OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships and Genatlas for AMIGO3 Gene

Publications for AMIGO3 Gene

  1. AMIGO, a transmembrane protein implicated in axon tract development, defines a novel protein family with leucine-rich repeats. (PMID: 12629050) Kuja-Panula J. … Rauvala H. (J. Cell Biol. 2003) 2 3 4
  2. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 2 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. Association analysis of 3p21 with Crohn's disease in a New Zealand population. (PMID: 20307617) Morgan A.R. … Ferguson L.R. (Hum. Immunol. 2010) 3 48
  5. Prediction of the coding sequences of unidentified human genes. XX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 11347906) Nagase T. … Ohara O. (DNA Res. 2001) 3 4

Products for AMIGO3 Gene

Sources for AMIGO3 Gene

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