Aliases for AMIGO2 Gene
Aliases for AMIGO2 Gene
External Ids for AMIGO2 Gene
- HGNC: 24073
- Entrez Gene: 347902
- Ensembl: ENSG00000139211
- OMIM: 615690
- UniProtKB: Q86SJ2
Previous GeneCards Identifiers for AMIGO2 Gene
- GC12M047186
- GC12M045756
- GC12M045755
- GC12M047469
- GC12M044500
Summaries for AMIGO2 Gene
GeneCards Summary for AMIGO2 Gene
AMIGO2 (Adhesion Molecule With Ig Like Domain 2) is a Protein Coding gene. Diseases associated with AMIGO2 include Gastric Adenocarcinoma. An important paralog of this gene is AMIGO1.
UniProtKB/Swiss-Prot for AMIGO2 Gene
-
Required for depolarization-dependent survival of cultured cerebellar granule neurons. May mediate homophilic as well as heterophilic cell-cell interaction with AMIGO1 or AMIGO3. May contribute to signal transduction through its intracellular domain. May be required for tumorigenesis of a subset of gastric adenocarcinomas.
No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for AMIGO2 Gene
Genomics for AMIGO2 Gene
Regulatory Elements for AMIGO2 Gene
- Transcription factor binding sites by QIAGEN in the AMIGO2 gene promoter:
Regulatory Element Products
Genomic Location for AMIGO2 Gene
- Chromosome:
- 12
- Start:
- 47,075,707 bp from pter
- End:
- 47,080,826 bp from pter
- Size:
- 5,120 bases
- Orientation:
- Minus strand
Genomic View for AMIGO2 Gene
- Cytogenetic band:
-
- 12q13.11 by Ensembl
- 12q13.11 by Entrez Gene
- 12q13.11 by HGNC
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for AMIGO2 Gene
Proteins for AMIGO2 Gene
-
Protein details for AMIGO2 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q86SJ2-AMGO2_HUMAN
- Recommended name:
- Amphoterin-induced protein 2
- Protein Accession:
- Q86SJ2
- Q4VBP6
- Q7Z4A0
- Q96CN8
Protein attributes for AMIGO2 Gene
- Size:
- 522 amino acids
- Molecular mass:
- 57934 Da
- Quaternary structure:
-
- Binds itself as well as AMIGO1 and AMIGO3.
Protein Expression for AMIGO2 Gene
Post-translational modifications for AMIGO2 Gene
Other Protein References for AMIGO2 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- R&D Systems Antibodies for AMIGO2 (AMIGO2)
- Novus Biologicals Antibodies for AMIGO2
- Invitrogen Antibodies for AMIGO2
- antibodies-online Antibodies for AMIGO2: See all 57
- Search GeneTex for Antibodies for AMIGO2
-
Santa Cruz Biotechnology (SCBT) Antibodies for AMIGO2
Protein Products
- R&D Systems Proteins and Enzymes for AMIGO2
-
OriGene Purified Proteins for AMIGO2
- Search Origene for MassSpec and Protein Over-expression Lysates for AMIGO2
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- Sino Biological Recombinant Proteins for AMIGO2
- Sino Biological Cell Lysates for AMIGO2
- ProSpec Recombinant Proteins for AMIGO2
- antibodies-online Proteins for AMIGO2: See all 5
- Search antibodies-online for peptides
- Search GeneTex for Proteins for AMIGO2
-
ProSci Proteins for AMIGO2
Assay Products
- antibodies-online Kits for AMIGO2: See all 7
No data available for DME Specific Peptides for AMIGO2 Gene
Domains & Families for AMIGO2 Gene
Gene Families for AMIGO2 Gene
Protein Domains for AMIGO2 Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for AMIGO2 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q86SJ2- Family:
-
- Belongs to the immunoglobulin superfamily. AMIGO family.
Function for AMIGO2 Gene
Molecular function for AMIGO2 Gene
- UniProtKB/Swiss-Prot Function:
- Required for depolarization-dependent survival of cultured cerebellar granule neurons. May mediate homophilic as well as heterophilic cell-cell interaction with AMIGO1 or AMIGO3. May contribute to signal transduction through its intracellular domain. May be required for tumorigenesis of a subset of gastric adenocarcinomas.
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005515 | protein binding | IPI | 21078624 |
Phenotypes for AMIGO2 Gene
- GenomeRNAi human phenotypes for AMIGO2:
-
- Increased vaccinia virus (VACV) infection
- Increased gamma-H2AX phosphorylation
- Downregulation of NF-kappaB pathway after LMP1 stimulation
- Decreased IL-8 secretion
- Synthetic lethal with MLN4924 (a NAE inhibitor)
- Weakly decreased NFAT1-GFP nuclear translocation
- Increased viability with MLN4924 (a NAE inhibitor)
Animal Model Products
-
Taconic Biosciences Mouse Models for AMIGO2
- Cyagen custom Knockout/knockin (KOKI) mouse models for AMIGO2
-
-
ViGene Biosciences lentiviral particle packaged cDNA for AMIGO2 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for AMIGO2 gene
- Search ViGene Biosciences for AMIGO2
CRISPR Products
-
OriGene CRISPR knockouts for AMIGO2
-
Santa Cruz Biotechnology (SCBT) CRISPR for AMIGO2
- GenScript: Design CRISPR guide RNA sequences for AMIGO2
miRNA for AMIGO2 Gene
- miRTarBase miRNAs that target AMIGO2
miRNA Products
- Search ViGene Biosciences for AMIGO2
Inhibitory RNA Products
- Origene shRNA, siRNA, and RNAi products in human, mouse, rat for AMIGO2
- Browse OriGene Inhibitory RNA Products For AMIGO2
-
ViGene Biosciences ready-to-package AAV shRNAs for AMIGO2 gene
Clone Products
- Sino Biological Human cDNA Clone for AMIGO2
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- Addgene plasmids for AMIGO2
- VectorBuilder custom plasmid, inducible vectors for AMIGO2
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for AMIGO2
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- R&D Systems cDNA Clones for AMIGO2
Cell Line Products
-
Horizon Cell Lines for AMIGO2
-
ViGene Biosciences adenoviral particle packaged cDNA for AMIGO2 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for AMIGO2 gene
-
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Flow Cytometry Products
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for AMIGO2 Gene
Localization for AMIGO2 Gene
Subcellular locations from UniProtKB/Swiss-Prot for AMIGO2 Gene
- Cell membrane; Single-pass type I membrane protein. Nucleus. Note=Associated with nucleus as well as plasma membrane. Restricted to somata of cerebellar as well as hippocampal neurons (By similarity). {ECO:0000250}.
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005634 | nucleus | IEA | -- |
| GO:0005886 | plasma membrane | IEA | -- |
| GO:0016020 | membrane | IEA | -- |
| GO:0016021 | integral component of membrane | IEA | -- |
Pathways & Interactions for AMIGO2 Gene
Interacting Proteins for AMIGO2 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0007155 | cell adhesion | IEA | -- |
| GO:0007156 | homophilic cell adhesion via plasma membrane adhesion molecules | ISS | 12629050 |
| GO:0007157 | heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules | ISS | 12629050 |
| GO:0043066 | negative regulation of apoptotic process | IEA | -- |
| GO:0043069 | negative regulation of programmed cell death | ISS | 12843293 |
No data available for Pathways by source and SIGNOR curated interactions for AMIGO2 Gene
Transcripts for AMIGO2 Gene
mRNA/cDNA for AMIGO2 Gene
- (3) REFSEQ mRNAs :
- (10) Additional mRNA sequences :
- (107) Selected AceView cDNA sequences:
- (3) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for AMIGO2 Gene
CRISPR Products
-
OriGene CRISPR knockouts for AMIGO2
-
Santa Cruz Biotechnology (SCBT) CRISPR for AMIGO2
- GenScript: Design CRISPR guide RNA sequences for AMIGO2
miRNA Products
- Search ViGene Biosciences for AMIGO2
Inhibitory RNA Products
- Origene shRNA, siRNA, and RNAi products in human, mouse, rat for AMIGO2
- Browse OriGene Inhibitory RNA Products For AMIGO2
-
ViGene Biosciences ready-to-package AAV shRNAs for AMIGO2 gene
Clone Products
- Sino Biological Human cDNA Clone for AMIGO2
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- Addgene plasmids for AMIGO2
- VectorBuilder custom plasmid, inducible vectors for AMIGO2
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for AMIGO2
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- R&D Systems cDNA Clones for AMIGO2
Flow Cytometry Products
| ExUns: | 1a | · | 1b | · | 1c | ^ | 2 | ^ | 3a | · | 3b | · | 3c |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | |||||||||||||
| SP2: | |||||||||||||
| SP3: | - |
Expression for AMIGO2 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
- Mesenchymal Stem Cells (Uncategorized)
- Umbilical Cord (Extraembryonic Tissues)
-
Heart (Cardiovascular System)
- Atrioventricular Canal Cells Atrioventricular Canal
-
Thymus (Hematopoietic System)
- T-Cytotoxic Cells Thymus
-
Blood (Cardiovascular System)
- T-Cytotoxic Cells Thymus
- Brain (Nervous System)
- Neural Tube (Nervous System)
mRNA differential expression in normal tissues according to GTEx for AMIGO2 Gene
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for AMIGO2 Gene
NURSA nuclear receptor signaling pathways regulating expression of AMIGO2 Gene:
AMIGO2SOURCE GeneReport for Unigene cluster for AMIGO2 Gene:
Hs.121520mRNA Expression by UniProt/SwissProt for AMIGO2 Gene:
Q86SJ2-AMGO2_HUMANEvidence on tissue expression from TISSUES for AMIGO2 Gene
- Stomach(4.2)
Primer Products
-
OriGene qPCR primer pairs for AMIGO2
No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for AMIGO2 Gene
Orthologs for AMIGO2 Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | AMIGO2 34 35 |
|
||
| cow (Bos Taurus) |
Mammalia | AMIGO2 34 35 |
|
||
| dog (Canis familiaris) |
Mammalia | AMIGO2 34 35 |
|
||
| mouse (Mus musculus) |
Mammalia | Amigo2 34 16 35 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Amigo2 34 |
|
||
| platypus (Ornithorhynchus anatinus) |
Mammalia | AMIGO2 35 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | AMIGO2 34 35 |
|
||
| lizard (Anolis carolinensis) |
Reptilia | AMIGO2 35 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | amigo2 34 |
|
||
| sea squirt (Ciona savignyi) |
Ascidiacea | -- 35 |
|
OneToMany |
- Species where no ortholog for AMIGO2 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- oppossum (Monodelphis domestica)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
- zebrafish (Danio rerio)
Paralogs for AMIGO2 Gene
Variants for AMIGO2 Gene
| SNP ID | Clin | Chr 12 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs1000071932 | -- | 47,079,799(+) | CGGGA(A/G/T)GGGGC | intron-variant, utr-variant-5-prime | |
| rs1000339042 | -- | 47,081,253(+) | ATAAC(A/T)TGTAA | intron-variant, upstream-variant-2KB | |
| rs1000368638 | -- | 47,081,006(+) | GAAGG(C/T)GCAAG | intron-variant, upstream-variant-2KB | |
| rs1001005665 | -- | 47,078,549(+) | TATGT(G/T)ATTGT | upstream-variant-2KB, reference, missense | |
| rs1001479528 | -- | 47,077,895(+) | CAGGC(G/T)TTGCT | upstream-variant-2KB, reference, missense |
Relevant External Links for AMIGO2 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- AMIGO2
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for AMIGO2 Gene
Disorders for AMIGO2 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| gastric adenocarcinoma |
|
|
Relevant External Links for AMIGO2
- Atlas of Genetics and Cytogenetics in Oncology and Haematology:
- AMIGO2
No data available for UniProtKB/Swiss-Prot and Genatlas for AMIGO2 Gene
Publications for AMIGO2 Gene
- DEGA/AMIGO-2, a leucine-rich repeat family member, differentially expressed in human gastric adenocarcinoma: effects on ploidy, chromosomal stability, cell adhesion/migration and tumorigenicity. (PMID: 15107827) Rabenau K.E. … Pereira D.S. (Oncogene 2004) 2 3 4 22 64
- Alivin 1, a novel neuronal activity-dependent gene, inhibits apoptosis and promotes survival of cerebellar granule neurons. (PMID: 12843293) Ono T. … Kawashima S. (J. Neurosci. 2003) 2 3 4 22 64
- AMIGO, a transmembrane protein implicated in axon tract development, defines a novel protein family with leucine-rich repeats. (PMID: 12629050) Kuja-Panula J. … Rauvala H. (J. Cell Biol. 2003) 2 3 4 64
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
- Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3 64
Products for AMIGO2 Gene
- R&D Systems Antibodies for AMIGO2 (AMIGO2)
- R&D Systems Proteins and Enzymes for AMIGO2
- Browse R&D Systems for biochemical assays
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- OriGene qPCR primer pairs for AMIGO2
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- GenScript: Design CRISPR guide RNA sequences for AMIGO2
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- Taconic Biosciences Mouse Models for AMIGO2
- Find your next knockout model in the Taconic Knockout Repository
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- Humanized Mice
- Addgene plasmids for AMIGO2
- antibodies-online Antibodies for AMIGO2: See all 57
- antibodies-online Kits for AMIGO2: See all 7
- antibodies-online Proteins for AMIGO2: See all 5
- Search antibodies-online for peptides
- Search GeneTex for Antibodies for AMIGO2
- Search GeneTex for Proteins for AMIGO2
- ViGene Biosciences adenoviral particle packaged cDNA for AMIGO2 gene
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- Search ViGene Biosciences for AMIGO2
- Santa Cruz Biotechnology (SCBT) Antibodies for AMIGO2
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- Search for AMIGO2 Antibodies at ProSci
- Custom Antibody Services
- ProSci Proteins for AMIGO2
- Horizon Cell Lines for AMIGO2
- Cyagen custom Knockout/knockin (KOKI) mouse models for AMIGO2
- VectorBuilder custom plasmid, inducible vectors for AMIGO2
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for AMIGO2
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Sources for AMIGO2 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) RNAdb
- (29) ASD
- (30) ECgene
- (31) GeneAnnot
- (32) CGAP SAGE
- (33) SOURCE
- (34) HomoloGene
- (35) PanEnsembl
- (36) euGenes
- (37) SGD
- (38) FlyBase
- (39) WormBase
- (40) Pseudogene
- (41) DGV
- (42) dbSNP
- (43) GenAtlas
- (44) GeneTests
- (45) HGMD
- (46) GAD
- (47) LSDB
- (48) BGMUT
- (49) HuGE
- (50) eBioscience
- (51) Atlas
- (52) Cell Signaling Technology
- (53) GenBank
- (54) H-invDB
- (55) HORDE
- (56) HUGE
- (57) IMGT
- (58) Leiden
- (59) MILLIPORE
- (60) miRBase
- (61) DME
- (62) NCBI
- (63) OriGene
- (64) PubMed
- (65) R&D Systems
- (66) TGDB
- (67) Tocris
- (68) Abcam
- (69) Novus
- (70) ProSpec
- (71) Sino Biological
- (72) GenScript
- (73) Qiagen
- (74) Cloud-Clone Corp.
- (75) Enzo Life Sciences
- (76) OCA
- (77) Proteopedia
- (78) MOPED
- (79) SPIRE
- (80) neXtProt
- (81) Reactome
- (82) GeneGo (Thomson Reuters)
- (83) fRNAdb
- (84) DISEASES
- (85) SIMAP
- (86) GenomeRNAi
- (87) LifeMap
- (88) miRTarBase
- (89) MalaCards
- (90) Invitrogen
- (91) BitterDB
- (92) Vector BioLabs
- (93) ESI-BIO
- (94) RefSeq
- (95) BioSystems
- (96) MaxQB
- (97) IUPHAR
- (98) BioGPS
- (99) Illumina
- (100) COMPARTMENTS
- (101) HOMER
- (102) PaxDb
- (103) ApexBio
- (104) Addgene
- (105) antibodies-online
- (106) CYP
- (107) NONCODE
- (108) SwitchGear Genomics
- (109) TreeFam
- (110) PathCards
- (111) GeneReviews
- (112) GeneTex
- (113) Taconic Biosciences
- (114) GTEx
- (115) ProteomicsDB
- (116) SCBT
- (117) DGIdb
- (118) ClinicalTrials
- (119) FDA Approved Drugs
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- (122) diseasecard
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- (128) Genetics Home Reference
- (129) MeSH
- (130) MedlinePlus
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- (132) NINDS
- (133) NCBI Bookshelf
- (134) ClinVar
- (135) Gene Damage Index
- (136) ViGene Biosciences
- (137) HPO
- (138) UDN
- (139) VISTA
- (140) FANTOM5
- (141) ENCODE
- (142) ProSci
- (143) Horizon
- (144) NURSA
- (145) IID
- (146) Cyagen
- (147) VectorBuilder
- (148) SNPedia
- (149) BRCA Exchange
- (150) St John's Lab
- (151) CIViC
- (152) ProteoGenix
- (153) dbSUPER
- (154) TISSUES
- (155) Gene ORGANizer




