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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

AMIGO2 Gene

protein-coding   GIFtS: 54
GCID: GC12M047469

adhesion molecule with Ig-like domain 2
 Explore 12 diseases affiliated with
AMIGO2 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for AMIGO2    

Aliases
for AMIGO2 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Adhesion Molecule With Ig-Like Domain 21 2     Amphoterin Induced Gene 22
ALI11 2 3     Amphoterin-Induced Protein 22
DEGA1 2 3     Differentially Expressed In Gastric Adenocarcinoma2
Differentially Expressed In Gastric Adenocarcinomas2 3     Transmembrane Protein AMIGO22
AMIGO-22 3     Alivin-13
Alivin 12     

External Ids:    HGNC: 240731   Entrez Gene: 3479022   Ensembl: ENSG000001392117   UniProtKB: Q86SJ23   

Export aliases for AMIGO2 gene to outside databases

Previous GC identifers: GC12M047186 GC12M045756 GC12M045755 GC12M044500


Summaries
for AMIGO2 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
UniProtKB/Swiss-Prot: AMGO2_HUMAN, Q86SJ2
Function: Required for depolarization-dependent survival of cultured cerebellar granule neurons. May mediate homophilic
as well as heterophilic cell-cell interaction with AMIGO1 or AMIGO3. May contribute to signal transduction through its
intracellular domain. May be required for tumorigenesis of a subset of gastric adenocarcinomas




Genomic Views
for AMIGO2 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000012.11  NC_018923.1  NT_029419.12  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the AMIGO2 gene promoter:
         LHX3b/Lhx3b   AML1a   GATA-3   Lmo2   RelA   AP-4   MEF-2A   LHX3a/Lhx3a   Cart-1   aMEF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: AMIGO2 promoter sequence
   Search SABiosciences Chromatin IP Primers for AMIGO2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat AMIGO2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q13.11   Ensembl cytogenetic band:  12q13.11   HGNC cytogenetic band: 12q13.11

AMIGO2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
AMIGO2 gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12M047469:  view genomic region     (about GC identifiers)

Start:
 47,469,490 bp from pter      End:
 47,473,734 bp from pter
Size:
 4,245 bases      Orientation:
 minus strand

Proteins
for AMIGO2 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: AMGO2_HUMAN, Q86SJ2 (See protein sequence)
Recommended Name: Amphoterin-induced protein 2 precursor  
Size: 522 amino acids; 57934 Da
Subunit: Binds itself as well as AMIGO1 and AMIGO3 (By similarity)
Subcellular location: Cell membrane; Single-pass type I membrane protein (By similarity). Nucleus (By similarity).
Note=Associated with nucleus as well as plasma membrane. Restricted to somata of cerebellar as well as hippocampal
neurons (By similarity)
Secondary accessions: Q4VBP6 Q7Z4A0 Q96CN8

Explore the universe of human proteins at neXtProt for AMIGO2: NX_Q86SJ2

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q86SJ2

    • AMIGO2 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (2 alternative transcripts): 
    NP_001137140.1  NP_862830.1  

    ENSEMBL proteins: 
     ENSP00000266581   ENSP00000449034   ENSP00000406020   ENSP00000320848  

    Human Recombinant Protein Products: 
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    OriGene Protein Over-expression Lysate (see all 2): AMIGO2
    OriGene Custom Protein Services for AMIGO2 
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    Novus Biologicals AMIGO2 Protein
    Novus Biologicals AMIGO2 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for AMIGO2

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--
    GO:0005886plasma membrane IEA--
    GO:0016021integral to membrane IEA--


    AMIGO2 for ontologies           About GeneDecksing



    AMIGO2 Antibody Products: 
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    ThermoFisher Antibodies for AMIGO2

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    Uscn ELISAs and CLIAs for AMIGO2

    Protein Domains /
    Families
    for AMIGO2 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    AMIGO2 for domains           About GeneDecksing

    5/7 InterPro domains/families (see all 7):
     IPR007110 Ig-like_dom
     IPR000483 Cys-rich_flank_reg_C
     IPR000372 LRR-contain_N
     IPR003599 Ig_sub
     IPR001611 Leu-rich_rpt

    Graphical View of Domain Structure for InterPro Entry Q86SJ2

    ProtoNet protein and cluster: Q86SJ2

    1 Blocks protein family: IPB003599 Immunoglobulin subtype

    UniProtKB/Swiss-Prot: AMGO2_HUMAN, Q86SJ2
    Similarity: Belongs to the immunoglobulin superfamily. AMIGO family
    Similarity: Contains 1 Ig-like C2-type (immunoglobulin-like) domain
    Similarity: Contains 6 LRR (leucine-rich) repeats
    Similarity: Contains 1 LRRCT domain
    Similarity: Contains 1 LRRNT domain


    Function
    for AMIGO2 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: AMGO2_HUMAN, Q86SJ2
    Function: Required for depolarization-dependent survival of cultured cerebellar granule neurons. May mediate homophilic
    as well as heterophilic cell-cell interaction with AMIGO1 or AMIGO3. May contribute to signal transduction through its
    intracellular domain. May be required for tumorigenesis of a subset of gastric adenocarcinomas

    miRNA
    Products:            		miRTarBase miRNAs that target AMIGO2:
    hsa-mir-155 (MIRT001573)

    OriGene 3'-UTR Clone (see all 2): AMIGO2
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat AMIGO2
    8/11 QIAGEN miScript miRNA Assays for microRNAs that regulate AMIGO2 (see all 11):
    hsa-miR-21* hsa-miR-4307 hsa-miR-7-2* hsa-miR-196a* hsa-miR-4306 hsa-miR-3065-5p hsa-miR-374a* hsa-miR-659
    SwitchGear 3'UTR luciferase reporter plasmid: AMIGO2 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for AMIGO2 (see all 7)
    OriGene shRNA RFP: AMIGO2
    OriGene siRNA: AMIGO2
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat AMIGO2

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for AMIGO2

    Clone
    Products:             		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for AMIGO2 (see all 6)
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    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector (see all 2): AMIGO2 (NM_181847)
    Browse Sino Biological Human cDNA Clones
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat AMIGO2 

    Cell Line
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    Search LifeMap BioReagents cell lines for AMIGO2

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for AMIGO2

    Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI--


    AMIGO2 for ontologies           About GeneDecksing


    2 GenomeRNAi human phenotypes for AMIGO2:
     Downregulation of NF-kappaB pa  Increased gamma-H2AX phosphory 


    Pathways & Interactions
    for AMIGO2 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Selected targets of GCR-alpha
    		Selected targets of GCR-alpha1.00

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    1 EMD Millipore Pathway for AMIGO2
        Selected targets of GCR-alpha




    AMIGO2 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for AMIGO2

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    4 Interacting proteins for AMIGO2 (Q86SJ21, 3 ENSP000003208484) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CACNA1AO005551, 3EBI-3866830,EBI-766279 I2D: score=1 
    AMIGO1Q86WK63I2D: score=2 
    AMIGO3Q86WK73I2D: score=2 
    --ensp: ENSP000002665814STRING: ensp: ENSP00000266581
    About this table

    Gene Ontology (GO): 4 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007156homophilic cell adhesion ISS12629050
    GO:0007157heterophilic cell-cell adhesion ISS12629050
    GO:0043066negative regulation of apoptotic process IEA--
    GO:0043069negative regulation of programmed cell death ISS12843293


    AMIGO2 for ontologies           About GeneDecksing



    Drugs & Compounds
    for AMIGO2 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for AMIGO2
    Search CenterWatch for drugs/clinical trials and news about AMIGO2 / AMGO2 

    Transcripts
    for AMIGO2 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for AMIGO2 gene (2 alternative transcripts): 
    NM_001143668.1  NM_181847.4  

    Unigene Cluster for AMIGO2:

    Adhesion molecule with Ig-like domain 2
    Hs.121520  [show with all ESTs]
    Unigene Representative Sequence: NM_181847
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000266581(uc001rpm.3 uc001rpk.3 uc001rpl.3) ENST00000550413
    ENST00000429635 ENST00000321382

    miRNA
    Products:             		 OriGene 3'-UTR Clone (see all 2): AMIGO2
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat AMIGO2
    8/11 QIAGEN miScript miRNA Assays for microRNAs that regulate AMIGO2 (see all 11):
    hsa-miR-21* hsa-miR-4307 hsa-miR-7-2* hsa-miR-196a* hsa-miR-4306 hsa-miR-3065-5p hsa-miR-374a* hsa-miR-659
    SwitchGear 3'UTR luciferase reporter plasmid: AMIGO2 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for AMIGO2 (see all 7)
    OriGene shRNA RFP: AMIGO2
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    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat AMIGO2
    Clone
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    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector (see all 2): AMIGO2 (NM_181847)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for AMIGO2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat AMIGO2 
    Primer
    Products:            		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for AMIGO2
    Browse OriGene validated miRNA SYBR primer pairs
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat AMIGO2
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat AMIGO2

    Additional cDNA sequence: 

    AB079074.1 AB080610.1 AK091761.1 AK093111.1 AL833007.1 AY237005.1 AY454159.1 BC014103.2 
    BC047595.1 BC095477.1 

    4 DOTS entries:

    DT.99978673  DT.91813348  DT.100024556  DT.95278719 

    24/107 AceView cDNA sequences (see all 107):

    BQ717394 AA330112 BQ000186 BE392628 AW194502 AA935581 AA564864 CA454644 
    AL047103 BU956148 BQ684715 AI378756 AY237005 BQ717396 AI955244 CB127412 
    AB080610 BQ000019 AA330352 BU501354 AA894447 AX747169 AK091761 BC014103 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for AMIGO2    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b · 3c
    SP1:                                          
    SP2:                                          
    SP3:                    -                     


    ECgene alternative splicing isoforms for AMIGO2

    Expression
    for AMIGO2 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    AMIGO2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TGCTTGTGTA

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    AMIGO2 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    1 LifeMap In Vivo Development Anatomical Compartment/Cell 
    Tissue Anatomical Compartment CellCategory (developmental path)
    Neural TubeMetencephalonNeural Tube
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See AMIGO2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for AMIGO2

    SOURCE GeneReport for Unigene cluster: Hs.121520

    UniProtKB/Swiss-Prot: AMGO2_HUMAN, Q86SJ2
    Tissue specificity: Highest levels in breast, ovary, cervix, and uterus. Lower levels in lung, colon, and rectum.
    Differentially expressed in 56% of thyroid, 57% of pancreatic and 45% of stomach cancers

        SABiosciences Custom PCR Arrays for AMIGO2
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    In Situ
    Assay Products:     
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    Orthologs
    for AMIGO2 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of chordates.

    Orthologs for AMIGO2 gene from 3/8 species (see all 8)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Amigo21 , 5 adhesion molecule with Ig like domain 21, 5 83.88(n)1
    88.63(a)1    		   15 (52.91 cM)5
    1058271  NM_001164563.11  NP_001158035.11 
     972440745 
    chicken
    (Gallus gallus)    		 Aves AMIGO21 adhesion molecule with Ig-like domain 2 68.97(n)
    67.37(a)    		   417810  NM_001199550.1  NP_001186479.1 
    lizard
    (Anolis carolinensis)    		 Reptilia AMIGO26
    		 --
    		 62(a)
    		 1 ↔ 1
    		 5(53189607-53191163)


    ENSEMBL Gene Tree for AMIGO2 (if available)
    TreeFam Gene Tree for AMIGO2 (if available) 

    Paralogs
    for AMIGO2 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for AMIGO2 gene
    AMIGO12  AMIGO32  
    2 SIMAP similar genes for AMIGO2 using alignment to 1 protein entry:     AMGO2_HUMAN:
    AMIGO1    AMIGO3

    AMIGO2 for paralogs           About GeneDecksing



    Genomic Variants
    for AMIGO2 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/119 NCBI SNPs in AMIGO2 are shown (see all 119)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 12 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs118300301,2
    		C,H,--47469004(+) TTCCCG/AGAATA 1 -- ds50015Minor allele frequency- A:0.05NA WA EA 244
    rs1428196231,2
    		--47469026(+) GAGAGC/TTTTCA 1 -- ds50010--------
    rs351921251,2
    		C,F,--47469047(+) GGTTTC/TCCTTG 1 -- ds50018Minor allele frequency- T:0.24NA WA CSA EA 368
    rs1125795091,2
    		C,--47469128(+) AGAGGTGA/-TGATT 1 -- ds50011Minor allele frequency- -:0.50CSA 2
    rs1910311411,2
    		--47469143(+) CAAGGC/TCATAC 1 -- ds50010--------
    rs1477364601,2
    		--47469159(+) ACAGAA/GTTCTT 1 -- ds50010--------
    rs111837221,2
    		C,F,H,--47469223(+) TGGCTC/GTGAAG 1 -- ds500126Minor allele frequency- G:0.19NS EA NA WA 3180
    rs1828063261,2
    		--47469250(+) TGAGGC/TTGGTG 1 -- ds50010--------
    rs1172006021,2
    		F,--47469288(+) ACACCA/CTCCAA 1 -- ds50011Minor allele frequency- C:0.03EA 120
    rs777786471,2
    		C,F,--47469409(+) CCCACA/GTGGCA 1 -- ds50011Minor allele frequency- G:0.04WA 118

    HapMap Linkage Disequilibrium report for AMIGO2 (47469490 - 47473734 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for AMIGO2: --

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing AMIGO2
    DNA2.0 Custom Variant and Variant Library Synthesis for AMIGO2

    Disorders / Diseases
    for AMIGO2 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    AMIGO2 for disorders           About GeneDecksing

    12 diseases for AMIGO2:    About MalaCards
    legg-calve-perthes disease    gastric adenocarcinoma    adenocarcinoma    spondylolisthesis
    macular degeneration    cerebral palsy    stomach cancer    cerebritis
    ataxia    thyroiditis    pancreatitis    neuronitis

    3 diseases from the University of Copenhagen DISEASES database for AMIGO2:
    Cerebral palsy     Legg-Calve-Perthes Disease     Spondylolisthesis

    Export disorders for AMIGO2 gene to outside databases

    Publications
    for AMIGO2 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for AMIGO2 gene, integrated from 9 sources (see all 12):
    (articles sorted by number of sources associating them with AMIGO2)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Alivin 1, a novel neuronal activity-dependent gene, inhibits apoptosis and promotes survival of cerebellar granule neurons. (PubMed id 12843293)1, 2, 3, 9 Ono T.... Kawashima S. (2003)
    2. DEGA/AMIGO-2, a leucine-rich repeat family member, differentially expressed in human gastric adenocarcinoma: effects on ploidy, chromosomal stability, cell adhesion/migration and tumorigenicity. (PubMed id 15107827)1, 2, 3, 9 Rabenau K.E.... Pereira D.S. (2004)
    3. AMIGO, a transmembrane protein implicated in axon tract development, defines a novel protein family with leucine-rich repeats. (PubMed id 12629050)1, 2, 3 Kuja-Panula J....Rauvala H. (2003)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    5. A genome-wide search for loci interacting with known p rostate cancer risk-associated genetic variants. (PubMed id 22219177)1 Tao S....Sun J. (2012)
    6. Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
    7. Comparison of an expanded ataxia interactome with pat ient medical records reveals a relationship between macular degeneration and at axia. (PubMed id 21078624)1 Kahle J.J....Zoghbi H.Y. (2011)
    8. The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)2 Bechtel S.... Schupp I. (2007)
    9. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)2 Olsen J.V....Mann M. (2006)
    10. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1 Ota T.... Sugano S. (2004)

    External Searches for AMIGO2 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
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    Genome Databases showing AMIGO2 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 347902 HGNC: 24073 AceView: AMIGO2 Ensembl:ENSG00000139211 euGenes: HUgn347902
    ECgene: AMIGO2 H-InvDB: AMIGO2

    Other Databases showing AMIGO2 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing AMIGO2 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for AMIGO2 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for AMIGO2 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for AMIGO2 gene:
    Search GeneIP for patents involving AMIGO2

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