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Aliases for AMIGO2 Gene

Aliases for AMIGO2 Gene

  • Adhesion Molecule With Ig-Like Domain 2 2 3
  • Differentially Expressed In Gastric Adenocarcinomas 3 4
  • AMIGO-2 3 4
  • ALI1 3 4
  • DEGA 3 4
  • Differentially Expressed In Gastric Adenocarcinoma 3
  • Amphoterin-Induced Gene And Open Reading Frame 2 2
  • Transmembrane Protein AMIGO2 3
  • Amphoterin Induced Gene 2 3
  • Alivin 1 3
  • Alivin-1 4

External Ids for AMIGO2 Gene

Previous GeneCards Identifiers for AMIGO2 Gene

  • GC12M047186
  • GC12M045756
  • GC12M045755
  • GC12M047469
  • GC12M044500

Summaries for AMIGO2 Gene

GeneCards Summary for AMIGO2 Gene

AMIGO2 (Adhesion Molecule With Ig-Like Domain 2) is a Protein Coding gene. Diseases associated with AMIGO2 include gastric adenocarcinoma. An important paralog of this gene is AMIGO1.

UniProtKB/Swiss-Prot for AMIGO2 Gene

  • Required for depolarization-dependent survival of cultured cerebellar granule neurons. May mediate homophilic as well as heterophilic cell-cell interaction with AMIGO1 or AMIGO3. May contribute to signal transduction through its intracellular domain. May be required for tumorigenesis of a subset of gastric adenocarcinomas

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for AMIGO2 Gene

Genomics for AMIGO2 Gene

Regulatory Elements for AMIGO2 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for AMIGO2 Gene

Chromosome:
12
Start:
47,075,707 bp from pter
End:
47,080,826 bp from pter
Size:
5,120 bases
Orientation:
Minus strand

Genomic View for AMIGO2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for AMIGO2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for AMIGO2 Gene

Proteins for AMIGO2 Gene

  • Protein details for AMIGO2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q86SJ2-AMGO2_HUMAN
    Recommended name:
    Amphoterin-induced protein 2
    Protein Accession:
    Q86SJ2
    Secondary Accessions:
    • Q4VBP6
    • Q7Z4A0
    • Q96CN8

    Protein attributes for AMIGO2 Gene

    Size:
    522 amino acids
    Molecular mass:
    57934 Da
    Quaternary structure:
    • Binds itself as well as AMIGO1 and AMIGO3.

neXtProt entry for AMIGO2 Gene

Proteomics data for AMIGO2 Gene at MOPED

Post-translational modifications for AMIGO2 Gene

  • Glycosylation at Asn 58, Asn 104, Asn 281, Asn 288, Asn 345, Asn 373, Asn 381, and Asn 384
  • Modification sites at PhosphoSitePlus

Other Protein References for AMIGO2 Gene

Antibody Products

No data available for DME Specific Peptides for AMIGO2 Gene

Domains & Families for AMIGO2 Gene

Gene Families for AMIGO2 Gene

Suggested Antigen Peptide Sequences for AMIGO2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q86SJ2

UniProtKB/Swiss-Prot:

AMGO2_HUMAN :
  • Contains 1 Ig-like C2-type (immunoglobulin-like) domain.
  • Belongs to the immunoglobulin superfamily. AMIGO family.
  • Contains 6 LRR (leucine-rich) repeats.
Domain:
  • Contains 1 Ig-like C2-type (immunoglobulin-like) domain.
  • Contains 1 LRRCT domain.
  • Contains 1 LRRNT domain.
Family:
  • Belongs to the immunoglobulin superfamily. AMIGO family.
Similarity:
  • Contains 6 LRR (leucine-rich) repeats.
genes like me logo Genes that share domains with AMIGO2: view

Function for AMIGO2 Gene

Molecular function for AMIGO2 Gene

UniProtKB/Swiss-Prot Function:
Required for depolarization-dependent survival of cultured cerebellar granule neurons. May mediate homophilic as well as heterophilic cell-cell interaction with AMIGO1 or AMIGO3. May contribute to signal transduction through its intracellular domain. May be required for tumorigenesis of a subset of gastric adenocarcinomas

Gene Ontology (GO) - Molecular Function for AMIGO2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 21078624
genes like me logo Genes that share ontologies with AMIGO2: view
genes like me logo Genes that share phenotypes with AMIGO2: view

Animal Model Products

miRNA for AMIGO2 Gene

miRTarBase miRNAs that target AMIGO2

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for AMIGO2 Gene

Localization for AMIGO2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for AMIGO2 Gene

Cell membrane; Single-pass type I membrane protein. Nucleus. Note=Associated with nucleus as well as plasma membrane. Restricted to somata of cerebellar as well as hippocampal neurons (By similarity). {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for AMIGO2 Gene COMPARTMENTS Subcellular localization image for AMIGO2 gene
Compartment Confidence
nucleus 3
plasma membrane 3
cytosol 2
golgi apparatus 2

Gene Ontology (GO) - Cellular Components for AMIGO2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005886 plasma membrane IEA --
GO:0016021 integral component of membrane IBA --
genes like me logo Genes that share ontologies with AMIGO2: view

Pathways & Interactions for AMIGO2 Gene

SuperPathways for AMIGO2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for AMIGO2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules ISS 12629050
GO:0007157 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules ISS 12629050
GO:0007420 brain development IBA --
GO:0043066 negative regulation of apoptotic process IEA --
GO:0043069 negative regulation of programmed cell death ISS 12843293
genes like me logo Genes that share ontologies with AMIGO2: view

No data available for Pathways by source and SIGNOR curated interactions for AMIGO2 Gene

Drugs & Compounds for AMIGO2 Gene

No Compound Related Data Available

Transcripts for AMIGO2 Gene

Unigene Clusters for AMIGO2 Gene

Adhesion molecule with Ig-like domain 2:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for AMIGO2

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for AMIGO2 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b · 3c
SP1:
SP2:
SP3: -

Relevant External Links for AMIGO2 Gene

GeneLoc Exon Structure for
AMIGO2
ECgene alternative splicing isoforms for
AMIGO2

Expression for AMIGO2 Gene

mRNA expression in normal human tissues for AMIGO2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for AMIGO2 Gene

This gene is overexpressed in Artery - Tibial (x6.5).

Protein differential expression in normal tissues from HIPED for AMIGO2 Gene

This gene is overexpressed in Amniocyte (60.2) and Testis (6.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for AMIGO2 Gene



SOURCE GeneReport for Unigene cluster for AMIGO2 Gene Hs.121520

mRNA Expression by UniProt/SwissProt for AMIGO2 Gene

Q86SJ2-AMGO2_HUMAN
Tissue specificity: Highest levels in breast, ovary, cervix, and uterus. Lower levels in lung, colon, and rectum. Differentially expressed in 56% of thyroid, 57% of pancreatic and 45% of stomach cancers.
genes like me logo Genes that share expression patterns with AMIGO2: view

Protein tissue co-expression partners for AMIGO2 Gene

Primer Products

In Situ Assay Products

Orthologs for AMIGO2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for AMIGO2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia AMIGO2 35
  • 89.76 (n)
  • 90.98 (a)
AMIGO2 36
  • 91 (a)
OneToOne
dog
(Canis familiaris)
Mammalia AMIGO2 35
  • 87.2 (n)
  • 91.17 (a)
AMIGO2 36
  • 91 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Amigo2 35
  • 83.88 (n)
  • 88.63 (a)
Amigo2 16
Amigo2 36
  • 89 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia AMIGO2 35
  • 99.81 (n)
  • 100 (a)
AMIGO2 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Amigo2 35
  • 83.43 (n)
  • 85.93 (a)
platypus
(Ornithorhynchus anatinus)
Mammalia AMIGO2 36
  • 64 (a)
OneToOne
chicken
(Gallus gallus)
Aves AMIGO2 35
  • 68.97 (n)
  • 67.37 (a)
AMIGO2 36
  • 67 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia AMIGO2 36
  • 62 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia amigo2 35
  • 65.89 (n)
  • 62.09 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 28 (a)
OneToMany
Species with no ortholog for AMIGO2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for AMIGO2 Gene

ENSEMBL:
Gene Tree for AMIGO2 (if available)
TreeFam:
Gene Tree for AMIGO2 (if available)

Paralogs for AMIGO2 Gene

Paralogs for AMIGO2 Gene

(2) SIMAP similar genes for AMIGO2 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with AMIGO2: view

Variants for AMIGO2 Gene

Sequence variations from dbSNP and Humsavar for AMIGO2 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type MAF
rs756313428 -- 47,076,511(+) TAAGA(C/T)ATTTT downstream-variant-500B, utr-variant-3-prime
rs755912880 -- 47,077,545(+) CTGGG(A/G)AAGAG synonymous-codon, reference
rs755896518 -- 47,077,479(+) TTGAC(C/T)GAATC reference, synonymous-codon
rs755078529 -- 47,077,009(+) TTTCT(A/C)CATCT utr-variant-3-prime
rs754703315 -- 47,077,563(+) TTCCC(A/G)TTCTG reference, synonymous-codon

Structural Variations from Database of Genomic Variants (DGV) for AMIGO2 Gene

Variant ID Type Subtype PubMed ID
nsv694 CNV Loss 18451855

Variation tolerance for AMIGO2 Gene

Residual Variation Intolerance Score: 13.03% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.56; 30.10% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for AMIGO2 Gene

HapMap Linkage Disequilibrium report
AMIGO2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for AMIGO2 Gene

Disorders for AMIGO2 Gene

MalaCards: The human disease database

(1) MalaCards diseases for AMIGO2 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
gastric adenocarcinoma
  • adenocarcinoma of stomach
- elite association

Relevant External Links for AMIGO2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
AMIGO2
genes like me logo Genes that share disorders with AMIGO2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for AMIGO2 Gene

Publications for AMIGO2 Gene

  1. DEGA/AMIGO-2, a leucine-rich repeat family member, differentially expressed in human gastric adenocarcinoma: effects on ploidy, chromosomal stability, cell adhesion/migration and tumorigenicity. (PMID: 15107827) Rabenau K.E. … Pereira D.S. (Oncogene 2004) 2 23 67
  2. Alivin 1, a novel neuronal activity-dependent gene, inhibits apoptosis and promotes survival of cerebellar granule neurons. (PMID: 12843293) Ono T. … Kawashima S. (J. Neurosci. 2003) 2 23 67
  3. AMIGO, a transmembrane protein implicated in axon tract development, defines a novel protein family with leucine-rich repeats. (PMID: 12629050) Kuja-Panula J. … Rauvala H. (J. Cell Biol. 2003) 2 67
  4. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 67
  5. A genome-wide search for loci interacting with known prostate cancer risk-associated genetic variants. (PMID: 22219177) Tao S. … Sun J. (Carcinogenesis 2012) 67

Products for AMIGO2 Gene

Sources for AMIGO2 Gene

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