Free for academic non-profit institutions. Other users need a Commercial license

Aliases for AMIGO2 Gene

Aliases for AMIGO2 Gene

  • Adhesion Molecule With Ig-Like Domain 2 2 3
  • ALI1 3 4 6
  • Differentially Expressed In Gastric Adenocarcinomas 3 4
  • AMIGO-2 3 4
  • DEGA 3 4
  • Differentially Expressed In Gastric Adenocarcinoma 3
  • Amphoterin-Induced Gene And Open Reading Frame 2 2
  • Amphoterin-Induced Protein 2 3
  • Transmembrane Protein AMIGO2 3
  • Amphoterin Induced Gene 2 3
  • Alivin 1 3
  • Alivin-1 4

External Ids for AMIGO2 Gene

Previous GeneCards Identifiers for AMIGO2 Gene

  • GC12M047186
  • GC12M045756
  • GC12M045755
  • GC12M047469
  • GC12M044500

Summaries for AMIGO2 Gene

GeneCards Summary for AMIGO2 Gene

AMIGO2 (Adhesion Molecule With Ig-Like Domain 2) is a Protein Coding gene. Diseases associated with AMIGO2 include gastric adenocarcinoma and legg-calve-perthes disease. An important paralog of this gene is AMIGO1.

UniProtKB/Swiss-Prot for AMIGO2 Gene

  • Required for depolarization-dependent survival of cultured cerebellar granule neurons. May mediate homophilic as well as heterophilic cell-cell interaction with AMIGO1 or AMIGO3. May contribute to signal transduction through its intracellular domain. May be required for tumorigenesis of a subset of gastric adenocarcinomas

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for AMIGO2 Gene

Genomics for AMIGO2 Gene

Regulatory Elements for AMIGO2 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for AMIGO2 Gene

47,075,707 bp from pter
47,079,951 bp from pter
4,245 bases
Minus strand

Genomic View for AMIGO2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for AMIGO2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for AMIGO2 Gene

Proteins for AMIGO2 Gene

  • Protein details for AMIGO2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Amphoterin-induced protein 2
    Protein Accession:
    Secondary Accessions:
    • Q4VBP6
    • Q7Z4A0
    • Q96CN8

    Protein attributes for AMIGO2 Gene

    522 amino acids
    Molecular mass:
    57934 Da
    Quaternary structure:
    • Binds itself as well as AMIGO1 and AMIGO3.

neXtProt entry for AMIGO2 Gene

Proteomics data for AMIGO2 Gene at MOPED

Post-translational modifications for AMIGO2 Gene

  • Glycosylation at Asn58, Asn104, Asn281, Asn288, Asn345, Asn373, Asn381, and Asn384
  • Modification sites at PhosphoSitePlus

Other Protein References for AMIGO2 Gene

No data available for DME Specific Peptides for AMIGO2 Gene

Domains for AMIGO2 Gene

Gene Families for AMIGO2 Gene

  • IGD :Immunoglobulin superfamily / Immunoglobulin-like domain containing

Suggested Antigen Peptide Sequences for AMIGO2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Q86SJ2
  • Contains 1 Ig-like C2-type (immunoglobulin-like) domain.
  • Contains 1 LRRCT domain.
  • Contains 1 LRRNT domain.
  • Belongs to the immunoglobulin superfamily. AMIGO family.
  • Contains 6 LRR (leucine-rich) repeats.
genes like me logo Genes that share domains with AMIGO2: view

Function for AMIGO2 Gene

Molecular function for AMIGO2 Gene

UniProtKB/Swiss-Prot Function: Required for depolarization-dependent survival of cultured cerebellar granule neurons. May mediate homophilic as well as heterophilic cell-cell interaction with AMIGO1 or AMIGO3. May contribute to signal transduction through its intracellular domain. May be required for tumorigenesis of a subset of gastric adenocarcinomas

Gene Ontology (GO) - Molecular Function for AMIGO2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 21078624
genes like me logo Genes that share ontologies with AMIGO2: view

Phenotypes for AMIGO2 Gene

genes like me logo Genes that share phenotypes with AMIGO2: view

Animal Model Products

CRISPR Products

miRNA for AMIGO2 Gene

miRTarBase miRNAs that target AMIGO2

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for AMIGO2 Gene

Localization for AMIGO2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for AMIGO2 Gene

Cell membrane; Single-pass type I membrane protein. Nucleus. Note=Associated with nucleus as well as plasma membrane. Restricted to somata of cerebellar as well as hippocampal neurons (By similarity). {ECO:0000250}.

Subcellular locations from

Jensen Localization Image for AMIGO2 Gene COMPARTMENTS Subcellular localization image for AMIGO2 gene
Compartment Confidence
plasma membrane 5
nucleus 2
cytosol 1
extracellular 1
lysosome 1
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for AMIGO2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005886 plasma membrane IEA --
GO:0016021 integral component of membrane IBA --
genes like me logo Genes that share ontologies with AMIGO2: view

Pathways for AMIGO2 Gene

SuperPathways for AMIGO2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for AMIGO2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules ISS 12629050
GO:0007157 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules ISS 12629050
GO:0007420 brain development IBA --
GO:0043066 negative regulation of apoptotic process IEA --
GO:0043069 negative regulation of programmed cell death ISS 12843293
genes like me logo Genes that share ontologies with AMIGO2: view

No data available for Pathways by source for AMIGO2 Gene

Transcripts for AMIGO2 Gene

Unigene Clusters for AMIGO2 Gene

Adhesion molecule with Ig-like domain 2:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for AMIGO2

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for AMIGO2

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for AMIGO2 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b · 3c
SP3: -

Relevant External Links for AMIGO2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for AMIGO2 Gene

mRNA expression in normal human tissues for AMIGO2 Gene

mRNA differential expression in normal tissues according to GTEx for AMIGO2 Gene

This gene is overexpressed in Artery - Tibial (6.5).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for AMIGO2 Gene

SOURCE GeneReport for Unigene cluster for AMIGO2 Gene Hs.121520

mRNA Expression by UniProt/SwissProt for AMIGO2 Gene

Tissue specificity: Highest levels in breast, ovary, cervix, and uterus. Lower levels in lung, colon, and rectum. Differentially expressed in 56% of thyroid, 57% of pancreatic and 45% of stomach cancers.
genes like me logo Genes that share expressions with AMIGO2: view

In Situ Assay Products

Orthologs for AMIGO2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for AMIGO2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia AMIGO2 35
  • 99.81 (n)
  • 100 (a)
  • 100 (a)
(Bos Taurus)
Mammalia AMIGO2 35
  • 89.76 (n)
  • 90.98 (a)
  • 91 (a)
(Canis familiaris)
Mammalia AMIGO2 35
  • 87.2 (n)
  • 91.17 (a)
  • 91 (a)
(Mus musculus)
Mammalia Amigo2 35
  • 83.88 (n)
  • 88.63 (a)
Amigo2 16
Amigo2 36
  • 89 (a)
(Ornithorhynchus anatinus)
Mammalia AMIGO2 36
  • 64 (a)
(Rattus norvegicus)
Mammalia Amigo2 35
  • 83.43 (n)
  • 85.93 (a)
(Gallus gallus)
Aves AMIGO2 35
  • 68.97 (n)
  • 67.37 (a)
  • 67 (a)
(Anolis carolinensis)
Reptilia AMIGO2 36
  • 62 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia amigo2 35
  • 65.89 (n)
  • 62.09 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 28 (a)
Species with no ortholog for AMIGO2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for AMIGO2 Gene

Gene Tree for AMIGO2 (if available)
Gene Tree for AMIGO2 (if available)

Paralogs for AMIGO2 Gene

Paralogs for AMIGO2 Gene

Selected SIMAP similar genes for AMIGO2 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with AMIGO2: view

Variants for AMIGO2 Gene

Sequence variations from dbSNP and Humsavar for AMIGO2 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type MAF
rs854888 -- 47,075,679(+) TATTA(C/T)TATTC downstream-variant-500B
rs854889 -- 47,077,254(+) TTTCT(A/C)TGGCA utr-variant-3-prime
rs10682029 -- 47,076,440(+) AACTT(-/A/TACTA)TAAGA intron-variant, utr-variant-3-prime, downstream-variant-500B
rs11183722 -- 47,075,440(+) TGGCT(C/G)TGAAG downstream-variant-500B
rs11830030 -- 47,075,221(+) ttccc(A/G)gAATA downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for AMIGO2 Gene

Variant ID Type Subtype PubMed ID
nsv694 CNV Loss 18451855

Relevant External Links for AMIGO2 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for AMIGO2 Gene

Disorders for AMIGO2 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (4) Diseases for AMIGO2 Gene including...

Search for AMIGO2 Gene in MalaCards »

(3) University of Copenhagen DISEASES for AMIGO2 Gene

genes like me logo Genes that share disorders with AMIGO2: view

No data available for UniProtKB/Swiss-Prot for AMIGO2 Gene

Publications for AMIGO2 Gene

  1. Alivin 1, a novel neuronal activity-dependent gene, inhibits apoptosis and promotes survival of cerebellar granule neurons. (PMID: 12843293) Ono T. … Kawashima S. (J. Neurosci. 2003) 2 3 4 23
  2. DEGA/AMIGO-2, a leucine-rich repeat family member, differentially expressed in human gastric adenocarcinoma: effects on ploidy, chromosomal stability, cell adhesion/migration and tumorigenicity. (PMID: 15107827) Rabenau K.E. … Pereira D.S. (Oncogene 2004) 2 3 4 23
  3. AMIGO, a transmembrane protein implicated in axon tract development, defines a novel protein family with leucine-rich repeats. (PMID: 12629050) Kuja-Panula J. … Rauvala H. (J. Cell Biol. 2003) 2 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. Comparison of an expanded ataxia interactome with patient medical records reveals a relationship between macular degeneration and ataxia. (PMID: 21078624) Kahle J.J. … Zoghbi H.Y. (Hum. Mol. Genet. 2011) 3

Products for AMIGO2 Gene

Sources for AMIGO2 Gene

Back to Top