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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

AMIGO2 Gene

protein-coding   GIFtS: 55
GCID: GC12M047469

Adhesion Molecule With Ig-Like Domain 2

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Adhesion Molecule With Ig-Like Domain 21 2     Alivin 12
Differentially Expressed In Gastric Adenocarcinomas2 3     Amphoterin Induced Gene 22
ALI12 3     Amphoterin-Induced Protein 22
AMIGO-22 3     Differentially Expressed In Gastric Adenocarcinoma2
DEGA2 3     Transmembrane Protein AMIGO22
Amphoterin-Induced Gene And Open Reading Frame 21     Alivin-13

External Ids:    HGNC: 240731   Entrez Gene: 3479022   Ensembl: ENSG000001392117   UniProtKB: Q86SJ23   

Export aliases for AMIGO2 gene to outside databases

Previous GC identifers: GC12M047186 GC12M045756 GC12M045755 GC12M044500


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for AMIGO2 Gene: 
AMIGO2 (adhesion molecule with Ig-like domain 2) is a protein-coding gene. Diseases associated with AMIGO2 include gastric adenocarcinoma, and legg-calve-perthes disease. GO annotations related to this gene include protein binding. An important paralog of this gene is AMIGO1.

UniProtKB/Swiss-Prot: AMGO2_HUMAN, Q86SJ2
Function: Required for depolarization-dependent survival of cultured cerebellar granule neurons. May mediate
homophilic as well as heterophilic cell-cell interaction with AMIGO1 or AMIGO3. May contribute to signal
transduction through its intracellular domain. May be required for tumorigenesis of a subset of gastric
adenocarcinomas




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000012.11  NT_029419.12  NC_018923.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the AMIGO2 gene promoter:
         LHX3b/Lhx3b   AML1a   GATA-3   Lmo2   RelA   AP-4   MEF-2A   LHX3a/Lhx3a   Cart-1   aMEF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidAMIGO2 promoter sequence
   Search SABiosciences Chromatin IP Primers for AMIGO2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat AMIGO2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q13.11   Ensembl cytogenetic band:  12q13.11   HGNC cytogenetic band: 12q13.11

AMIGO2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
AMIGO2 gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12M047469:  view genomic region     (about GC identifiers)

Start:
47,469,490 bp from pter      End:
47,473,734 bp from pter
Size:
4,245 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: AMGO2_HUMAN, Q86SJ2 (See protein sequence)
Recommended Name: Amphoterin-induced protein 2 precursor  
Size: 522 amino acids; 57934 Da
Subunit: Binds itself as well as AMIGO1 and AMIGO3 (By similarity)
Subcellular location: Cell membrane; Single-pass type I membrane protein (By similarity). Nucleus (By similarity).
Note=Associated with nucleus as well as plasma membrane. Restricted to somata of cerebellar as well as
hippocampal neurons (By similarity)
Secondary accessions: Q4VBP6 Q7Z4A0 Q96CN8

Explore the universe of human proteins at neXtProt for AMIGO2: NX_Q86SJ2

Explore proteomics data for AMIGO2 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q86SJ2

  • AMIGO2 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    AMIGO2 Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_001137140.1  NP_862830.1  

    ENSEMBL proteins: 
     ENSP00000266581   ENSP00000449034   ENSP00000406020   ENSP00000320848  

    Human Recombinant Protein Products for AMIGO2: 
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    Novus Biologicals AMIGO2 Protein
    Novus Biologicals AMIGO2 Lysates
    Sino Biological Recombinant Protein for AMIGO2
    Sino Biological Cell Lysate for AMIGO2 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for AMIGO2 

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--
    GO:0005886plasma membrane IEA--
    GO:0016021integral to membrane IEA--

    AMIGO2 for ontologies           About GeneDecksing



    AMIGO2 Antibody Products: 
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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    IGD: Immunoglobulin superfamily / Immunoglobulin-like domain containing

    5/7 InterPro protein domains (see all 7):
     IPR007110 Ig-like_dom
     IPR000483 Cys-rich_flank_reg_C
     IPR000372 LRR-contain_N
     IPR003599 Ig_sub
     IPR001611 Leu-rich_rpt

    Graphical View of Domain Structure for InterPro Entry Q86SJ2

    ProtoNet protein and cluster: Q86SJ2

    1 Blocks protein domain: IPB003599 Immunoglobulin subtype

    UniProtKB/Swiss-Prot: AMGO2_HUMAN, Q86SJ2
    Similarity: Belongs to the immunoglobulin superfamily. AMIGO family
    Similarity: Contains 1 Ig-like C2-type (immunoglobulin-like) domain
    Similarity: Contains 6 LRR (leucine-rich) repeats
    Similarity: Contains 1 LRRCT domain
    Similarity: Contains 1 LRRNT domain


    AMIGO2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: AMGO2_HUMAN, Q86SJ2
    Function: Required for depolarization-dependent survival of cultured cerebellar granule neurons. May mediate
    homophilic as well as heterophilic cell-cell interaction with AMIGO1 or AMIGO3. May contribute to signal
    transduction through its intracellular domain. May be required for tumorigenesis of a subset of gastric
    adenocarcinomas

         Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI--
         
    AMIGO2 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for AMIGO2:
     Downregulation of NF-kappaB pa  Increased gamma-H2AX phosphory 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for AMIGO2 
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for AMIGO2 
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    miRTarBase miRNAs that target AMIGO2:
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat AMIGO2
    8/11 QIAGEN miScript miRNA Assays for microRNAs that regulate AMIGO2 (see all 11):
    hsa-miR-21* hsa-miR-4307 hsa-miR-7-2* hsa-miR-196a* hsa-miR-4306 hsa-miR-3065-5p hsa-miR-374a* hsa-miR-659
    SwitchGear 3'UTR luciferase reporter plasmidAMIGO2 3' UTR sequence
    Inhib. RNA
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for AMIGO2


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for AMIGO2 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Selected targets of GCR-alpha
    Selected targets of GCR-alpha

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 EMD Millipore Pathway for AMIGO2
        Selected targets of GCR-alpha





    AMIGO2 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for AMIGO2

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    4 Interacting proteins for AMIGO2 (Q86SJ21, 3 ENSP000003208484) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CACNA1AO005551, 3EBI-3866830,EBI-766279 I2D: score=1 
    AMIGO1Q86WK63I2D: score=2 
    AMIGO3Q86WK73I2D: score=2 
    --ensp: ENSP000002665814STRING: ensp: ENSP00000266581
    About this table

    Gene Ontology (GO): 4 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007156homophilic cell adhesion ISS12629050
    GO:0007157heterophilic cell-cell adhesion ISS12629050
    GO:0043066negative regulation of apoptotic process IEA--
    GO:0043069negative regulation of programmed cell death ISS12843293

    AMIGO2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for AMIGO2 (AMGO2)

    Search CenterWatch for drugs/clinical trials and news about AMIGO2 / AMGO2

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for AMIGO2 gene (2 alternative transcripts): 
    NM_001143668.1  NM_181847.4  

    Unigene Cluster for AMIGO2:

    Adhesion molecule with Ig-like domain 2
    Hs.121520  [show with all ESTs]
    Unigene Representative Sequence: NM_181847
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000266581(uc001rpm.3 uc001rpk.3 uc001rpl.3) ENST00000550413
    ENST00000429635 ENST00000321382
    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat AMIGO2
    8/11 QIAGEN miScript miRNA Assays for microRNAs that regulate AMIGO2 (see all 11):
    hsa-miR-21* hsa-miR-4307 hsa-miR-7-2* hsa-miR-196a* hsa-miR-4306 hsa-miR-3065-5p hsa-miR-374a* hsa-miR-659
    SwitchGear 3'UTR luciferase reporter plasmidAMIGO2 3' UTR sequence
    Inhib. RNA
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      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat AMIGO2

    Additional mRNA sequence: 

    AB079074.1 AB080610.1 AK091761.1 AK093111.1 AL833007.1 AY237005.1 AY454159.1 BC014103.2 
    BC047595.1 BC095477.1 

    4 DOTS entries:

    DT.99978673  DT.91813348  DT.100024556  DT.95278719 

    24/107 AceView cDNA sequences (see all 107):

    BQ000186 AA330352 CB127412 BQ717396 BQ717394 BC014103 AB079074 AK091761 
    AL047103 AX747169 AI378756 AB080610 AA935581 BE392628 AA714566 AA564864 
    CA454644 BU956148 AW194502 AY237005 AA330112 BQ684715 AA894447 AI955244 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for AMIGO2    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b · 3c
    SP1:                                          
    SP2:                                          
    SP3:                    -                     


    ECgene alternative splicing isoforms for AMIGO2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    AMIGO2 expression in normal human tissues (normalized intensities)      AMIGO2 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGCTTGTGTA
    AMIGO2 Expression
    About this image


    AMIGO2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/6 selected tissues (see all 6) fully expand
     
     Brain (Nervous System)    fully expand to see all 17 entries
             Thalamus
             Septum   
     
     Neural Tube (Nervous System)    fully expand to see all 2 entries
             Metencephalon
             brain/midbrain/lateral wall   
     
     Spinal Cord (Nervous System)    fully expand to see all 2 entries
             Dorsal Horn   
     
     Thymus (Hematopoietic System)
             T-Cytotoxic Cells Thymus
     
     Heart (Cardiovascular System)
             Atrioventricular Canal Cells Atrioventricular Canal

    See AMIGO2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for AMIGO2

    SOURCE GeneReport for Unigene cluster: Hs.121520

    UniProtKB/Swiss-Prot: AMGO2_HUMAN, Q86SJ2
    Tissue specificity: Highest levels in breast, ovary, cervix, and uterus. Lower levels in lung, colon, and rectum.
    Differentially expressed in 56% of thyroid, 57% of pancreatic and 45% of stomach cancers

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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for AMIGO2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for AMIGO2 gene from 3/9 species (see all 9)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Amigo21 , 5 adhesion molecule with Ig like domain 21, 5 83.88(n)1
    88.63(a)1
      15 (52.91 cM)5
    1058271  NM_001164563.11  NP_001158035.11 
     972440745 
    chicken
    (Gallus gallus)
    Aves AMIGO21 adhesion molecule with Ig-like domain 2 68.97(n)
    67.37(a)
      417810  NM_001199550.1  NP_001186479.1 
    lizard
    (Anolis carolinensis)
    Reptilia AMIGO26
    Uncharacterized protein
    63(a)
    1 ↔ 1
    5(53189607-53191163)


    ENSEMBL Gene Tree for AMIGO2 (if available)
    TreeFam Gene Tree for AMIGO2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for AMIGO2 gene
    AMIGO12  AMIGO32  
    2 SIMAP similar genes for AMIGO2 using alignment to 1 protein entry:     AMGO2_HUMAN:
    AMIGO1    AMIGO3

    AMIGO2 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/164 SNPs in AMIGO2 are shown (see all 164)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 12 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs118300301,2
    C,H--47469004(+) ttcccG/AgAATA 1 -- ds50015Minor allele frequency- A:0.05NA WA EA 244
    rs1428196231,2
    --47469026(+) GAGAGC/TTTTCA 1 -- ds50010--------
    rs351921251,2
    C,F--47469047(+) GGTTTC/TCCTTG 1 -- ds50018Minor allele frequency- T:0.24NA WA CSA EA 368
    rs1125795091,2
    C--47469128(+) AGAGGTGA/-TGATT 1 -- ds50011Minor allele frequency- -:0.50CSA 2
    rs1910311411,2
    --47469143(+) CAAGGC/TCATAC 1 -- ds50010--------
    rs1477364601,2
    --47469159(+) ACAGAA/GTTCTT 1 -- ds50010--------
    rs111837221,2
    C,F,H--47469223(+) TGGCTC/GTGAAG 1 -- ds500126Minor allele frequency- G:0.19NS EA NA WA 3180
    rs1828063261,2
    --47469250(+) TGAGGC/TTGGTG 1 -- ds50010--------
    rs1172006021,2
    C,F--47469288(+) ACACCA/CTCCAA 1 -- ds50011Minor allele frequency- C:0.03EA 120
    rs777786471,2
    C,F--47469409(+) CCCACA/GTGGCA 1 -- ds50011Minor allele frequency- G:0.04WA 118

    HapMap Linkage Disequilibrium report for AMIGO2 (47469490 - 47473734 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for AMIGO2:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv694CNV Loss18451855

    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing AMIGO2
    DNA2.0 Custom Variant and Variant Library Synthesis for AMIGO2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    12 diseases for AMIGO2:    About MalaCards
    gastric adenocarcinoma    legg-calve-perthes disease    adenocarcinoma    spondylolisthesis
    stomach cancer    cerebral palsy    macular degeneration    cerebritis
    ataxia    thyroiditis    neuronitis    pancreatitis

    3 diseases from the University of Copenhagen DISEASES database for AMIGO2:
    Cerebral palsy     Legg-Calve-Perthes Disease     Spondylolisthesis

    AMIGO2 for disorders           About GeneDecksing


    Export disorders for AMIGO2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for AMIGO2 gene, integrated from 9 sources (see all 13):
    (articles sorted by number of sources associating them with AMIGO2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Alivin 1, a novel neuronal activity-dependent gene, inhibits apoptosis and promotes survival of cerebellar granule neurons. (PubMed id 12843293)1, 2, 3, 9 Ono T.... Kawashima S. (2003)
    2. DEGA/AMIGO-2, a leucine-rich repeat family member, differentially expressed in human gastric adenocarcinoma: effects on ploidy, chromosomal stability, cell adhesion/migration and tumorigenicity. (PubMed id 15107827)1, 2, 3, 9 Rabenau K.E.... Pereira D.S. (2004)
    3. AMIGO, a transmembrane protein implicated in axon tract development, defines a novel protein family with leucine-rich repeats. (PubMed id 12629050)1, 2, 3 Kuja-Panula J....Rauvala H. (2003)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    5. A genome-wide search for loci interacting with known p rostate cancer risk-associated genetic variants. (PubMed id 22219177)1 Tao S....Sun J. (2012)
    6. Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. (PubMed id 23000965)1 Povlsen L.K....Choudhary C. (2012)
    7. Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
    8. Comparison of an expanded ataxia interactome with pat ient medical records reveals a relationship between macular degeneration and at axia. (PubMed id 21078624)1 Kahle J.J....Zoghbi H.Y. (2011)
    9. The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)2 Bechtel S.... Schupp I. (2007)
    10. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)2 Olsen J.V....Mann M. (2006)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 347902 HGNC: 24073 AceView: AMIGO2 Ensembl:ENSG00000139211 euGenes: HUgn347902
    ECgene: AMIGO2 H-InvDB: AMIGO2

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for AMIGO2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for AMIGO2 gene:
    Search GeneIP for patents involving AMIGO2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
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