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AMIGO2 Gene

protein-coding   GIFtS: 55
GCID: GC12M047469

Adhesion Molecule With Ig-Like Domain 2

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Adhesion Molecule With Ig-Like Domain 21 2     Alivin 12
ALI12 3 5     Amphoterin Induced Gene 22
Differentially Expressed In Gastric Adenocarcinomas2 3     Amphoterin-Induced Protein 22
AMIGO-22 3     Differentially Expressed In Gastric Adenocarcinoma2
DEGA2 3     Transmembrane Protein AMIGO22
Amphoterin-Induced Gene And Open Reading Frame 21     Alivin-13

External Ids:    HGNC: 240731   Entrez Gene: 3479022   Ensembl: ENSG000001392117   OMIM: 6156905   UniProtKB: Q86SJ23   

Export aliases for AMIGO2 gene to outside databases

Previous GC identifers: GC12M047186 GC12M045756 GC12M045755 GC12M044500


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for AMIGO2 Gene:
AMIGO2 (adhesion molecule with Ig-like domain 2) is a protein-coding gene. Diseases associated with AMIGO2 include gastric adenocarcinoma, and legg-calve-perthes disease. An important paralog of this gene is AMIGO1.

UniProtKB/Swiss-Prot: AMGO2_HUMAN, Q86SJ2
Function: Required for depolarization-dependent survival of cultured cerebellar granule neurons. May mediate
homophilic as well as heterophilic cell-cell interaction with AMIGO1 or AMIGO3. May contribute to signal
transduction through its intracellular domain. May be required for tumorigenesis of a subset of gastric
adenocarcinomas




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000012.12  NT_029419.13  NC_018923.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the AMIGO2 gene promoter:
         LHX3b/Lhx3b   AML1a   GATA-3   Lmo2   RelA   AP-4   MEF-2A   LHX3a/Lhx3a   Cart-1   aMEF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidAMIGO2 promoter sequence
   Search Chromatin IP Primers for AMIGO2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat AMIGO2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q13.11   Ensembl cytogenetic band:  12q13.11   HGNC cytogenetic band: 12q13.11

AMIGO2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
AMIGO2 gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12M047469:  view genomic region     (about GC identifiers)

Start:
47,469,490 bp from pter      End:
47,473,734 bp from pter
Size:
4,245 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: AMGO2_HUMAN, Q86SJ2 (See protein sequence)
Recommended Name: Amphoterin-induced protein 2 precursor  
Size: 522 amino acids; 57934 Da
Subunit: Binds itself as well as AMIGO1 and AMIGO3 (By similarity)
Secondary accessions: Q4VBP6 Q7Z4A0 Q96CN8

Explore the universe of human proteins at neXtProt for AMIGO2: NX_Q86SJ2

Explore proteomics data for AMIGO2 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn58, Asn104, Asn281, Asn288, Asn345, Asn373, Asn381, Asn384

  • See AMIGO2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001137140.1  NP_862830.1  

    ENSEMBL proteins: 
     ENSP00000266581   ENSP00000449034   ENSP00000406020   ENSP00000320848  

    AMIGO2 Human Recombinant Protein Products:

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    Sino Biological Recombinant Protein for AMIGO2
    Sino Biological Cell Lysate for AMIGO2
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    Cloud-Clone Corp. Proteins for AMIGO2

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    LSBio Antibodies in human, mouse, rat for AMIGO2

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    Cloud-Clone Corp. CLIAs for AMIGO2


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    IGD: Immunoglobulin superfamily / Immunoglobulin-like domain containing

    Selected InterPro protein domains (see all 7):
     IPR000483 Cys-rich_flank_reg_C
     IPR001611 Leu-rich_rpt
     IPR013783 Ig-like_fold
     IPR003591 Leu-rich_rpt_typical-subtyp
     IPR007110 Ig-like_dom

    Graphical View of Domain Structure for InterPro Entry Q86SJ2

    ProtoNet protein and cluster: Q86SJ2

    1 Blocks protein domain: IPB003599 Immunoglobulin subtype

    UniProtKB/Swiss-Prot: AMGO2_HUMAN, Q86SJ2
    Similarity: Belongs to the immunoglobulin superfamily. AMIGO family
    Similarity: Contains 1 Ig-like C2-type (immunoglobulin-like) domain
    Similarity: Contains 6 LRR (leucine-rich) repeats
    Similarity: Contains 1 LRRCT domain
    Similarity: Contains 1 LRRNT domain


    AMIGO2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: AMGO2_HUMAN, Q86SJ2
    Function: Required for depolarization-dependent survival of cultured cerebellar granule neurons. May mediate
    homophilic as well as heterophilic cell-cell interaction with AMIGO1 or AMIGO3. May contribute to signal
    transduction through its intracellular domain. May be required for tumorigenesis of a subset of gastric
    adenocarcinomas

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI--
         
    AMIGO2 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for AMIGO2:
     Downregulation of NF-kappaB pa  Increased gamma-H2AX phosphory 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for AMIGO2
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for AMIGO2
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for AMIGO2

    miRNA
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    miRTarBase miRNAs that target AMIGO2:
    hsa-mir-155-5p (MIRT001573), hsa-mir-124-3p (MIRT022417)

    Block miRNA regulation of human, mouse, rat AMIGO2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate AMIGO2 (see all 11):
    hsa-miR-21* hsa-miR-4307 hsa-miR-7-2* hsa-miR-196a* hsa-miR-4306 hsa-miR-3065-5p hsa-miR-374a* hsa-miR-659
    SwitchGear 3'UTR luciferase reporter plasmidAMIGO2 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for AMIGO2
    Predesigned siRNA for gene silencing in human, mouse, rat AMIGO2

    Gene Editing
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    Sino Biological Human cDNA Clone for AMIGO2
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat AMIGO2

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    Browse ESI BIO Cell Lines and PureStem Progenitors for AMIGO2 
    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for AMIGO2


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    AMGO2_HUMAN, Q86SJ2: Cell membrane; Single-pass type I membrane protein (By similarity). Nucleus (By similarity).
    Note=Associated with nucleus as well as plasma membrane. Restricted to somata of cerebellar as well as
    hippocampal neurons (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5
    nucleus2
    cytosol1
    extracellular1
    lysosome1
    mitochondrion1
    peroxisome1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--
    GO:0005886plasma membrane IEA--
    GO:0016021integral component of membrane IEA--

    AMIGO2 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for AMIGO2 About    
    See pathways by source

    SuperPathContained pathways About
    1Selected targets of GCR alpha
    Selected targets of GCR alpha




        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for AMIGO2
    Interactions:

        Search GeneGlobe Interaction Network for AMIGO2

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    4 Interacting proteins for AMIGO2 (Q86SJ21, 3 ENSP000003208484) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CACNA1AO005551, 3EBI-3866830,EBI-766279 I2D: score=1 
    AMIGO1Q86WK63I2D: score=2 
    AMIGO3Q86WK73I2D: score=2 
    --ensp: ENSP000002665814STRING: ensp: ENSP00000266581
    About this table

    Gene Ontology (GO): 4 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007156homophilic cell adhesion ISS12629050
    GO:0007157heterophilic cell-cell adhesion ISS12629050
    GO:0043066negative regulation of apoptotic process IEA--
    GO:0043069negative regulation of programmed cell death ISS12843293

    AMIGO2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for AMIGO2 (AMGO2)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for AMIGO2 gene (2 alternative transcripts): 
    NM_001143668.1  NM_181847.4  

    Unigene Cluster for AMIGO2:

    Adhesion molecule with Ig-like domain 2
    Hs.121520  [show with all ESTs]
    Unigene Representative Sequence: NM_181847
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000266581(uc001rpm.3 uc001rpk.3 uc001rpl.3) ENST00000550413
    ENST00000429635 ENST00000321382
    miRNA
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    Block miRNA regulation of human, mouse, rat AMIGO2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate AMIGO2 (see all 11):
    hsa-miR-21* hsa-miR-4307 hsa-miR-7-2* hsa-miR-196a* hsa-miR-4306 hsa-miR-3065-5p hsa-miR-374a* hsa-miR-659
    SwitchGear 3'UTR luciferase reporter plasmidAMIGO2 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for AMIGO2
    Predesigned siRNA for gene silencing in human, mouse, rat AMIGO2
    Clone
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    OriGene ORF clones in mouse, rat for AMIGO2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): AMIGO2 (NM_181847)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for AMIGO2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat AMIGO2
    Primer
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    OriGene qSTAR qPCR primer pairs in human, mouse for AMIGO2
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat AMIGO2
      QuantiTect SYBR Green Assays in human, mouse, rat AMIGO2
      QuantiFast Probe-based Assays in human, mouse, rat AMIGO2

    Additional mRNA sequence: 

    AB079074.1 AB080610.1 AK091761.1 AK093111.1 AL833007.1 AY237005.1 AY454159.1 BC014103.2 
    BC047595.1 BC095477.1 

    4 DOTS entries:

    DT.99978673  DT.91813348  DT.100024556  DT.95278719 

    Selected AceView cDNA sequences (see all 107):

    AB079074 CA454644 AY237005 AA935581 AW194502 AK091761 AA564864 AL047103 
    BU956148 AA330352 BQ717396 AA330112 BC014103 BE392628 AI955244 AB080610 
    BQ717394 AI378756 BQ000019 BQ684715 CB127412 AA714566 BQ000186 AA894447 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for AMIGO2    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b · 3c
    SP1:                                          
    SP2:                                          
    SP3:                    -                     


    ECgene alternative splicing isoforms for AMIGO2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    AMIGO2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGCTTGTGTA
    AMIGO2 Expression
    About this image


    AMIGO2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 5) fully expand
     
     Brain (Nervous System)    fully expand to see all 17 entries
             Thalamus
             Septum   
     
     Neural Tube (Nervous System)    fully expand to see all 2 entries
             Metencephalon
             brain/midbrain/lateral wall   
     
     Thymus (Hematopoietic System)
             T-Cytotoxic Cells Thymus
     
     Heart (Cardiovascular System)
             Atrioventricular Canal Cells Atrioventricular Canal
     
     Blood (Cardiovascular System)
             T-Cytotoxic Cells Thymus
    AMIGO2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    AMIGO2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.121520

    UniProtKB/Swiss-Prot: AMGO2_HUMAN, Q86SJ2
    Tissue specificity: Highest levels in breast, ovary, cervix, and uterus. Lower levels in lung, colon, and rectum.
    Differentially expressed in 56% of thyroid, 57% of pancreatic and 45% of stomach cancers

        Custom PCR Arrays for AMIGO2
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for AMIGO2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for AMIGO2 gene from Selected species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Amigo21 , 5 adhesion molecule with Ig like domain 21, 5 83.88(n)1
    88.63(a)1
      15 (52.91 cM)5
    1058271  NM_001164563.11  NP_001158035.11 
     972440745 
    chicken
    (Gallus gallus)
    Aves AMIGO21 adhesion molecule with Ig-like domain 2 68.97(n)
    67.37(a)
      417810  NM_001199550.1  NP_001186479.1 
    lizard
    (Anolis carolinensis)
    Reptilia AMIGO26
    adhesion molecule with Ig-like domain 2
    62(a)
    1 ↔ 1
    5(53189607-53191163)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia amigo21 adhesion molecule with Ig-like domain 2 65.89(n)
    62.09(a)
      100489302  XM_002932819.2  XP_002932865.1 


    ENSEMBL Gene Tree for AMIGO2 (if available)
    TreeFam Gene Tree for AMIGO2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for AMIGO2 gene
    AMIGO12  AMIGO32  
    2 SIMAP similar genes for AMIGO2 using alignment to 1 protein entry:     AMGO2_HUMAN:
    AMIGO1    AMIGO3

    AMIGO2 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for AMIGO2 (see all 164)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 12 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs118300301,2
    C,H--47469004(+) ttcccG/AgAATA 1 -- ds50015Minor allele frequency- A:0.05NA WA EA 244
    rs1428196231,2
    --47469026(+) GAGAGC/TTTTCA 1 -- ds50010--------
    rs351921251,2
    C,F--47469047(+) GGTTTC/TCCTTG 1 -- ds50018Minor allele frequency- T:0.24NA WA CSA EA 368
    rs1125795091,2
    C--47469128(+) AGAGGTGA/-TGATT 1 -- ds50011Minor allele frequency- -:0.50CSA 2
    rs1910311411,2
    --47469143(+) CAAGGC/TCATAC 1 -- ds50010--------
    rs1477364601,2
    --47469159(+) ACAGAA/GTTCTT 1 -- ds50010--------
    rs111837221,2
    C,F,H--47469223(+) TGGCTC/GTGAAG 1 -- ds500126Minor allele frequency- G:0.19NS EA NA WA 3180
    rs1828063261,2
    --47469250(+) TGAGGC/TTGGTG 1 -- ds50010--------
    rs1172006021,2
    C,F--47469288(+) ACACCA/CTCCAA 1 -- ds50011Minor allele frequency- C:0.03EA 120
    rs777786471,2
    C,F--47469409(+) CCCACA/GTGGCA 1 -- ds50011Minor allele frequency- G:0.04WA 118

    HapMap Linkage Disequilibrium report for AMIGO2 (47469490 - 47473734 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for AMIGO2:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv694CNV Loss18451855

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing AMIGO2
    DNA2.0 Custom Variant and Variant Library Synthesis for AMIGO2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 615690    OMIM disorders: --

    13 diseases for AMIGO2:    
    About MalaCards
    gastric adenocarcinoma    legg-calve-perthes disease    spondylolisthesis    adenocarcinoma
    stomach cancer    cerebral palsy    cerebritis    ataxia
    thyroiditis    neuronitis    pancreatitis    prostate cancer
    prostatitis

    3 diseases from the University of Copenhagen DISEASES database for AMIGO2:
    Cerebral palsy     Legg-Calve-Perthes Disease     Spondylolisthesis

    AMIGO2 for disorders           About GeneDecksing


    Export disorders for AMIGO2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for AMIGO2 gene, integrated from 10 sources (see all 13):
    (articles sorted by number of sources associating them with AMIGO2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Alivin 1, a novel neuronal activity-dependent gene, inhibits apoptosis and promotes survival of cerebellar granule neurons. (PubMed id 12843293)1, 2, 3, 9 Ono T.... Kawashima S. (J. Neurosci. 2003)
    2. DEGA/AMIGO-2, a leucine-rich repeat family member, differentially expressed in human gastric adenocarcinoma: effects on ploidy, chromosomal stability, cell adhesion/migration and tumorigenicity. (PubMed id 15107827)1, 2, 3, 9 Rabenau K.E.... Pereira D.S. (Oncogene 2004)
    3. AMIGO, a transmembrane protein implicated in axon tract development, defines a novel protein family with leucine-rich repeats. (PubMed id 12629050)1, 2, 3 Kuja-Panula J....Rauvala H. (J. Cell Biol. 2003)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    5. A genome-wide search for loci interacting with known prostate cancer risk-associated genetic variants. (PubMed id 22219177)1 Tao S....Sun J. (Carcinogenesis 2012)
    6. Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. (PubMed id 23000965)1 Povlsen L.K....Choudhary C. (Nat. Cell Biol. 2012)
    7. Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (amp 2011)
    8. Comparison of an expanded ataxia interactome with patient medical records reveals a relationship between macular degeneration and ataxia. (PubMed id 21078624)1 Kahle J.J....Zoghbi H.Y. (Hum. Mol. Genet. 2011)
    9. The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)2 Bechtel S.... Schupp I. (BMC Genomics 2007)
    10. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)2 Olsen J.V....Mann M. (Cell 2006)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 347902 HGNC: 24073 AceView: AMIGO2 Ensembl:ENSG00000139211 euGenes: HUgn347902
    ECgene: AMIGO2 H-InvDB: AMIGO2

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for AMIGO2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for AMIGO2 gene:
    Search GeneIP for patents involving AMIGO2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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