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Aliases for AMIGO2 Gene

Aliases for AMIGO2 Gene

  • Adhesion Molecule With Ig Like Domain 2 2 3 5
  • Differentially Expressed In Gastric Adenocarcinomas 3 4
  • AMIGO-2 3 4
  • ALI1 3 4
  • DEGA 3 4
  • Differentially Expressed In Gastric Adenocarcinoma 3
  • Amphoterin-Induced Gene And Open Reading Frame 2 2
  • Amphoterin-Induced Protein 2 3
  • Transmembrane Protein AMIGO2 3
  • Amphoterin Induced Gene 2 3
  • Alivin 1 3
  • Alivin-1 4

External Ids for AMIGO2 Gene

Previous GeneCards Identifiers for AMIGO2 Gene

  • GC12M047186
  • GC12M045756
  • GC12M045755
  • GC12M047469
  • GC12M044500

Summaries for AMIGO2 Gene

GeneCards Summary for AMIGO2 Gene

AMIGO2 (Adhesion Molecule With Ig Like Domain 2) is a Protein Coding gene. Diseases associated with AMIGO2 include Gastric Adenocarcinoma. An important paralog of this gene is AMIGO1.

UniProtKB/Swiss-Prot for AMIGO2 Gene

  • Required for depolarization-dependent survival of cultured cerebellar granule neurons. May mediate homophilic as well as heterophilic cell-cell interaction with AMIGO1 or AMIGO3. May contribute to signal transduction through its intracellular domain. May be required for tumorigenesis of a subset of gastric adenocarcinomas.

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for AMIGO2 Gene

Genomics for AMIGO2 Gene

Regulatory Elements for AMIGO2 Gene

Enhancers for AMIGO2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH12G047211 1.9 FANTOM5 Ensembl ENCODE dbSUPER 16.8 -134.6 -134592 8.7 HDGF PKNOX1 CREB3L1 ARNT SIN3A ZBTB7B ZNF766 CBX5 ZNF207 FOS RPAP3 AMIGO2 SENP1 ENSG00000258181 PCED1B PCED1B-AS1 GC12M047038
GH12G047204 1.8 FANTOM5 Ensembl ENCODE dbSUPER 17.1 -126.9 -126855 6.2 HDGF PKNOX1 TCF12 ZNF766 GATA2 ELK1 FOS CAVIN1 NCOA1 JUNB AMIGO2 PCED1B-AS1 PCED1B GC12M047038 GC12P047188
GH12G047188 1.4 Ensembl ENCODE dbSUPER 16 -110.9 -110920 6.3 HDGF PKNOX1 FEZF1 BRCA1 YY1 ZNF766 GATA2 FOS REST ZNF623 AMIGO2 ENSG00000199566 ENSG00000258181 PCED1B-AS1 GC12P047188 GC12M047038
GH12G047392 1.7 FANTOM5 Ensembl ENCODE dbSUPER 10.9 -312.8 -312810 1.7 HDAC1 PKNOX1 TBL1XR1 ARNT FEZF1 BMI1 ZNF121 GATA2 FOS ZEB2 ENSG00000199566 AMIGO2 LINC02156 MIR4494
GH12G047221 1.5 Ensembl ENCODE dbSUPER 11.2 -142.1 -142128 4.8 ATF1 FOXA2 ARNT SIN3A DMAP1 YY1 ETS1 TCF12 ZNF766 GATA2 AMIGO2 ENSG00000199566 ENSG00000258181 PCED1B PCED1B-AS1 GC12P047244
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around AMIGO2 on UCSC Golden Path with GeneCards custom track

Promoters for AMIGO2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000051335 826 2401 PKNOX1 CREB3L1 ARNT SIN3A ZNF2 FOS KLF13 DEK SP3 REST

Genomic Location for AMIGO2 Gene

Chromosome:
12
Start:
47,075,707 bp from pter
End:
47,080,826 bp from pter
Size:
5,120 bases
Orientation:
Minus strand

Genomic View for AMIGO2 Gene

Genes around AMIGO2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
AMIGO2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for AMIGO2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for AMIGO2 Gene

Proteins for AMIGO2 Gene

  • Protein details for AMIGO2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q86SJ2-AMGO2_HUMAN
    Recommended name:
    Amphoterin-induced protein 2
    Protein Accession:
    Q86SJ2
    Secondary Accessions:
    • Q4VBP6
    • Q7Z4A0
    • Q96CN8

    Protein attributes for AMIGO2 Gene

    Size:
    522 amino acids
    Molecular mass:
    57934 Da
    Quaternary structure:
    • Binds itself as well as AMIGO1 and AMIGO3.

neXtProt entry for AMIGO2 Gene

Post-translational modifications for AMIGO2 Gene

  • Glycosylation at posLast=5858, Asn104, Asn281, posLast=288288, Asn345, posLast=373373, Asn381, and Asn384
  • Modification sites at PhosphoSitePlus

Other Protein References for AMIGO2 Gene

No data available for DME Specific Peptides for AMIGO2 Gene

Domains & Families for AMIGO2 Gene

Gene Families for AMIGO2 Gene

Suggested Antigen Peptide Sequences for AMIGO2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q86SJ2

UniProtKB/Swiss-Prot:

AMGO2_HUMAN :
  • Belongs to the immunoglobulin superfamily. AMIGO family.
Family:
  • Belongs to the immunoglobulin superfamily. AMIGO family.
genes like me logo Genes that share domains with AMIGO2: view

Function for AMIGO2 Gene

Molecular function for AMIGO2 Gene

UniProtKB/Swiss-Prot Function:
Required for depolarization-dependent survival of cultured cerebellar granule neurons. May mediate homophilic as well as heterophilic cell-cell interaction with AMIGO1 or AMIGO3. May contribute to signal transduction through its intracellular domain. May be required for tumorigenesis of a subset of gastric adenocarcinomas.

Gene Ontology (GO) - Molecular Function for AMIGO2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 21078624
genes like me logo Genes that share ontologies with AMIGO2: view
genes like me logo Genes that share phenotypes with AMIGO2: view

Animal Model Products

  • Taconic Biosciences Mouse Models for AMIGO2

CRISPR Products

miRNA for AMIGO2 Gene

miRTarBase miRNAs that target AMIGO2

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for AMIGO2 Gene

Localization for AMIGO2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for AMIGO2 Gene

Cell membrane; Single-pass type I membrane protein. Nucleus. Note=Associated with nucleus as well as plasma membrane. Restricted to somata of cerebellar as well as hippocampal neurons (By similarity). {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for AMIGO2 gene
Compartment Confidence
plasma membrane 5
nucleus 3
cytosol 2
golgi apparatus 2
extracellular 1
mitochondrion 1
peroxisome 1
lysosome 1

Gene Ontology (GO) - Cellular Components for AMIGO2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005886 plasma membrane IEA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with AMIGO2: view

Pathways & Interactions for AMIGO2 Gene

SuperPathways for AMIGO2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for AMIGO2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007155 cell adhesion IEA --
GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules ISS 12629050
GO:0007157 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules ISS 12629050
GO:0043066 negative regulation of apoptotic process IEA --
GO:0043069 negative regulation of programmed cell death ISS 12843293
genes like me logo Genes that share ontologies with AMIGO2: view

No data available for Pathways by source and SIGNOR curated interactions for AMIGO2 Gene

Drugs & Compounds for AMIGO2 Gene

No Compound Related Data Available

Transcripts for AMIGO2 Gene

Unigene Clusters for AMIGO2 Gene

Adhesion molecule with Ig-like domain 2:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for AMIGO2 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b · 3c
SP1:
SP2:
SP3: -

Relevant External Links for AMIGO2 Gene

GeneLoc Exon Structure for
AMIGO2
ECgene alternative splicing isoforms for
AMIGO2

Expression for AMIGO2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for AMIGO2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for AMIGO2 Gene

This gene is overexpressed in Artery - Tibial (x6.5).

Protein differential expression in normal tissues from HIPED for AMIGO2 Gene

This gene is overexpressed in Amniocyte (60.2) and Testis (6.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for AMIGO2 Gene



Protein tissue co-expression partners for AMIGO2 Gene

NURSA nuclear receptor signaling pathways regulating expression of AMIGO2 Gene:

AMIGO2

SOURCE GeneReport for Unigene cluster for AMIGO2 Gene:

Hs.121520

mRNA Expression by UniProt/SwissProt for AMIGO2 Gene:

Q86SJ2-AMGO2_HUMAN
Tissue specificity: Highest levels in breast, ovary, cervix, and uterus. Lower levels in lung, colon, and rectum. Differentially expressed in 56% of thyroid, 57% of pancreatic and 45% of stomach cancers.

Evidence on tissue expression from TISSUES for AMIGO2 Gene

  • Stomach(4.2)
genes like me logo Genes that share expression patterns with AMIGO2: view

Primer Products

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for AMIGO2 Gene

Orthologs for AMIGO2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for AMIGO2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia AMIGO2 34 35
  • 99.81 (n)
cow
(Bos Taurus)
Mammalia AMIGO2 34 35
  • 89.76 (n)
dog
(Canis familiaris)
Mammalia AMIGO2 34 35
  • 87.2 (n)
mouse
(Mus musculus)
Mammalia Amigo2 34 16 35
  • 83.88 (n)
rat
(Rattus norvegicus)
Mammalia Amigo2 34
  • 83.43 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia AMIGO2 35
  • 64 (a)
OneToOne
chicken
(Gallus gallus)
Aves AMIGO2 34 35
  • 68.97 (n)
lizard
(Anolis carolinensis)
Reptilia AMIGO2 35
  • 62 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia amigo2 34
  • 65.89 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 28 (a)
OneToMany
Species where no ortholog for AMIGO2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for AMIGO2 Gene

ENSEMBL:
Gene Tree for AMIGO2 (if available)
TreeFam:
Gene Tree for AMIGO2 (if available)

Paralogs for AMIGO2 Gene

Paralogs for AMIGO2 Gene

(2) SIMAP similar genes for AMIGO2 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with AMIGO2: view

Variants for AMIGO2 Gene

Sequence variations from dbSNP and Humsavar for AMIGO2 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs1000071932 -- 47,079,799(+) CGGGA(A/G/T)GGGGC intron-variant, utr-variant-5-prime
rs1000339042 -- 47,081,253(+) ATAAC(A/T)TGTAA intron-variant, upstream-variant-2KB
rs1000368638 -- 47,081,006(+) GAAGG(C/T)GCAAG intron-variant, upstream-variant-2KB
rs1001005665 -- 47,078,549(+) TATGT(G/T)ATTGT upstream-variant-2KB, reference, missense
rs1001479528 -- 47,077,895(+) CAGGC(G/T)TTGCT upstream-variant-2KB, reference, missense

Structural Variations from Database of Genomic Variants (DGV) for AMIGO2 Gene

Variant ID Type Subtype PubMed ID
nsv558784 CNV gain 21841781
nsv694 CNV deletion 18451855

Variation tolerance for AMIGO2 Gene

Residual Variation Intolerance Score: 13% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.56; 30.10% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for AMIGO2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
AMIGO2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for AMIGO2 Gene

Disorders for AMIGO2 Gene

MalaCards: The human disease database

(1) MalaCards diseases for AMIGO2 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
gastric adenocarcinoma
  • adenocarcinoma of stomach
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for AMIGO2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
AMIGO2
genes like me logo Genes that share disorders with AMIGO2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for AMIGO2 Gene

Publications for AMIGO2 Gene

  1. DEGA/AMIGO-2, a leucine-rich repeat family member, differentially expressed in human gastric adenocarcinoma: effects on ploidy, chromosomal stability, cell adhesion/migration and tumorigenicity. (PMID: 15107827) Rabenau K.E. … Pereira D.S. (Oncogene 2004) 2 3 4 22 64
  2. Alivin 1, a novel neuronal activity-dependent gene, inhibits apoptosis and promotes survival of cerebellar granule neurons. (PMID: 12843293) Ono T. … Kawashima S. (J. Neurosci. 2003) 2 3 4 22 64
  3. AMIGO, a transmembrane protein implicated in axon tract development, defines a novel protein family with leucine-rich repeats. (PMID: 12629050) Kuja-Panula J. … Rauvala H. (J. Cell Biol. 2003) 2 3 4 64
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  5. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3 64

Products for AMIGO2 Gene

Sources for AMIGO2 Gene

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