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Aliases for AMIGO1 Gene

Aliases for AMIGO1 Gene

  • Adhesion Molecule With Ig-Like Domain 1 2 3
  • ALI2 3 4 6
  • Alivin-2 3 4
  • KIAA1163 4 6
  • AMIGO-1 3 4
  • AMIGO 3 4
  • Amphoterin-Induced Gene And Open Reading Frame 2
  • Amphoterin-Induced Gene And ORF 3
  • Amphoterin-Induced Protein 1 3

External Ids for AMIGO1 Gene

Summaries for AMIGO1 Gene

GeneCards Summary for AMIGO1 Gene

AMIGO1 (Adhesion Molecule With Ig-Like Domain 1) is a Protein Coding gene. An important paralog of this gene is AMIGO2.

UniProtKB/Swiss-Prot for AMIGO1 Gene

  • Promotes growth and fasciculation of neurites from cultured hippocampal neurons. May be involved in fasciculation as well as myelination of developing neural axons. May have a role in regeneration as well as neural plasticity in the adult nervous system. May mediate homophilic as well as heterophilic cell-cell interaction and contribute to signal transduction through its intracellular domain (By similarity).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for AMIGO1 Gene

Genomics for AMIGO1 Gene

Genomic Location for AMIGO1 Gene

Start:
109,504,175 bp from pter
End:
109,509,738 bp from pter
Size:
5,564 bases
Orientation:
Minus strand

Genomic View for AMIGO1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for AMIGO1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for AMIGO1 Gene

Regulatory Elements for AMIGO1 Gene

Proteins for AMIGO1 Gene

  • Protein details for AMIGO1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q86WK6-AMGO1_HUMAN
    Recommended name:
    Amphoterin-induced protein 1
    Protein Accession:
    Q86WK6
    Secondary Accessions:
    • B4DIM3
    • Q8IW71
    • Q9ULQ7

    Protein attributes for AMIGO1 Gene

    Size:
    493 amino acids
    Molecular mass:
    55239 Da
    Quaternary structure:
    • Homodimer, and heterodimer with AMIGO2 and AMIGO3.

neXtProt entry for AMIGO1 Gene

Proteomics data for AMIGO1 Gene at MOPED

Post-translational modifications for AMIGO1 Gene

  • Modification sites at PhosphoSitePlus
  • Glycosylation at Asn72, Asn264, Asn315, Asn349, and Asn360

Other Protein References for AMIGO1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for AMIGO1 Gene

Domains for AMIGO1 Gene

Gene Families for AMIGO1 Gene

HGNC:
  • VSET :Immunoglobulin superfamily / V-set domain containing

UniProtKB/Swiss-Prot:

AMGO1_HUMAN
Domain:
  • The LRR repeat region mediates homodimerization.:
    • Q86WK6
  • Contains 1 Ig-like C2-type (immunoglobulin-like) domain.:
    • Q86WK6
  • Contains 1 LRRCT domain.:
    • Q86WK6
  • Contains 1 LRRNT domain.:
    • Q86WK6
Family:
  • Belongs to the immunoglobulin superfamily. AMIGO family.:
    • Q86WK6
Similarity:
  • Contains 6 LRR (leucine-rich) repeats.:
    • Q86WK6
genes like me logo Genes that share domains with AMIGO1: view

Function for AMIGO1 Gene

Molecular function for AMIGO1 Gene

UniProtKB/Swiss-Prot Function: Promotes growth and fasciculation of neurites from cultured hippocampal neurons. May be involved in fasciculation as well as myelination of developing neural axons. May have a role in regeneration as well as neural plasticity in the adult nervous system. May mediate homophilic as well as heterophilic cell-cell interaction and contribute to signal transduction through its intracellular domain (By similarity).

Gene Ontology (GO) - Molecular Function for AMIGO1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with AMIGO1: view

Phenotypes for AMIGO1 Gene

GenomeRNAi human phenotypes for AMIGO1:
genes like me logo Genes that share phenotypes with AMIGO1: view

miRNA for AMIGO1 Gene

miRTarBase miRNAs that target AMIGO1

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for AMIGO1 Gene

Localization for AMIGO1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for AMIGO1 Gene

Cell membrane; Single-pass type I membrane protein. Cell projection, axon. Note=Associated with axons of neuronal cells. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for AMIGO1 Gene COMPARTMENTS Subcellular localization image for AMIGO1 gene
Compartment Confidence
plasma membrane 5
cytosol 1
lysosome 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for AMIGO1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IEA --
GO:0016021 integral component of membrane IBA --
GO:0030424 axon IEA --
GO:0042995 cell projection --
genes like me logo Genes that share ontologies with AMIGO1: view

Pathways for AMIGO1 Gene

SuperPathways for AMIGO1 Gene

No Data Available

Interacting Proteins for AMIGO1 Gene

Gene Ontology (GO) - Biological Process for AMIGO1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules ISS 12629050
GO:0007157 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules ISS 12629050
GO:0007409 axonogenesis IEA --
GO:0007413 axonal fasciculation ISS 12629050
GO:0007420 brain development IBA --
genes like me logo Genes that share ontologies with AMIGO1: view

No data available for Pathways by source for AMIGO1 Gene

Transcripts for AMIGO1 Gene

mRNA/cDNA for AMIGO1 Gene

Unigene Clusters for AMIGO1 Gene

Adhesion molecule with Ig-like domain 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for AMIGO1 Gene

No ASD Table

Relevant External Links for AMIGO1 Gene

GeneLoc Exon Structure for
AMIGO1
ECgene alternative splicing isoforms for
AMIGO1

Expression for AMIGO1 Gene

mRNA expression in normal human tissues for AMIGO1 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for AMIGO1 Gene

SOURCE GeneReport for Unigene cluster for AMIGO1 Gene Hs.726479

genes like me logo Genes that share expressions with AMIGO1: view

Orthologs for AMIGO1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for AMIGO1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia AMIGO1 36
  • 99.93 (n)
  • 100 (a)
AMIGO1 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia AMIGO1 36
  • 92.8 (n)
  • 95.76 (a)
AMIGO1 37
  • 95 (a)
OneToOne
dog
(Canis familiaris)
Mammalia AMIGO1 36
  • 92.09 (n)
  • 95.54 (a)
AMIGO1 37
  • 96 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Amigo1 36
  • 87.8 (n)
  • 89.63 (a)
Amigo1 16
Amigo1 37
  • 90 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia AMIGO1 37
  • 75 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia AMIGO1 37
  • 57 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Amigo1 36
  • 87.83 (n)
  • 89.45 (a)
lizard
(Anolis carolinensis)
Reptilia AMIGO1 37
  • 58 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia amigo1 36
  • 60.53 (n)
  • 59.31 (a)
zebrafish
(Danio rerio)
Actinopterygii amigo1 36
  • 59.7 (n)
  • 56.68 (a)
amigo1 37
  • 54 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 26 (a)
OneToMany
Species with no ortholog for AMIGO1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for AMIGO1 Gene

ENSEMBL:
Gene Tree for AMIGO1 (if available)
TreeFam:
Gene Tree for AMIGO1 (if available)

Paralogs for AMIGO1 Gene

Paralogs for AMIGO1 Gene

Selected SIMAP similar genes for AMIGO1 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with AMIGO1: view

Variants for AMIGO1 Gene

Sequence variations from dbSNP and Humsavar for AMIGO1 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs472737 -- 109,511,600(+) gcttc(A/G)ctggg upstream-variant-2KB
rs919958 -- 109,510,526(+) TAAAC(C/G)AGTGC upstream-variant-2KB
rs2483789 -- 109,511,323(-) CAGAA(A/C)ATCTT upstream-variant-2KB
rs2570972 -- 109,509,517(+) CGCCC(A/G)CCTTA utr-variant-5-prime
rs2692708 -- 109,511,283(-) tcttt(C/T)ttttt upstream-variant-2KB

Relevant External Links for AMIGO1 Gene

HapMap Linkage Disequilibrium report
AMIGO1

No data available for Structural Variations from Database of Genomic Variants (DGV) for AMIGO1 Gene

Disorders for AMIGO1 Gene

No disorders were found for AMIGO1 Gene.

No data available for UniProtKB/Swiss-Prot for AMIGO1 Gene

Publications for AMIGO1 Gene

  1. AMIGO, a transmembrane protein implicated in axon tract development, defines a novel protein family with leucine-rich repeats. (PMID: 12629050) Kuja-Panula J. … Rauvala H. (J. Cell Biol. 2003) 2 3 4 23
  2. Characterization of cDNA clones selected by the GeneMark analysis from size-fractionated cDNA libraries from human brain. (PMID: 10574461) Hirosawa M. … Ohara O. (DNA Res. 1999) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory S.G. … Bentley D.R. (Nature 2006) 3 4
  5. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PMID: 17207965) Lamesch P. … Vidal M. (Genomics 2007) 3

Products for AMIGO1 Gene

Sources for AMIGO1 Gene

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