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Aliases for AMIGO1 Gene

Aliases for AMIGO1 Gene

  • Adhesion Molecule With Ig-Like Domain 1 2 3 5
  • Alivin-2 3 4
  • AMIGO-1 3 4
  • AMIGO 3 4
  • ALI2 3 4
  • Amphoterin-Induced Gene And Open Reading Frame 2
  • Amphoterin-Induced Gene And ORF 3
  • KIAA1163 4

External Ids for AMIGO1 Gene

Previous GeneCards Identifiers for AMIGO1 Gene

  • GC01M109763
  • GC01M109848
  • GC01M110046
  • GC01M107942

Summaries for AMIGO1 Gene

GeneCards Summary for AMIGO1 Gene

AMIGO1 (Adhesion Molecule With Ig-Like Domain 1) is a Protein Coding gene. An important paralog of this gene is AMIGO2.

UniProtKB/Swiss-Prot for AMIGO1 Gene

  • Promotes growth and fasciculation of neurites from cultured hippocampal neurons. May be involved in fasciculation as well as myelination of developing neural axons. May have a role in regeneration as well as neural plasticity in the adult nervous system. May mediate homophilic as well as heterophilic cell-cell interaction and contribute to signal transduction through its intracellular domain. Assembled with KCNB1 modulates the gating characteristics of the delayed rectifier voltage-dependent potassium channel KCNB1.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for AMIGO1 Gene

Genomics for AMIGO1 Gene

Regulatory Elements for AMIGO1 Gene

Promoters for AMIGO1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around AMIGO1 on UCSC Golden Path with GeneCards custom track

Genomic Location for AMIGO1 Gene

Chromosome:
1
Start:
109,504,175 bp from pter
End:
109,509,738 bp from pter
Size:
5,564 bases
Orientation:
Minus strand

Genomic View for AMIGO1 Gene

Genes around AMIGO1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
AMIGO1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for AMIGO1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for AMIGO1 Gene

Proteins for AMIGO1 Gene

  • Protein details for AMIGO1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q86WK6-AMGO1_HUMAN
    Recommended name:
    Amphoterin-induced protein 1
    Protein Accession:
    Q86WK6
    Secondary Accessions:
    • B4DIM3
    • Q8IW71
    • Q9ULQ7

    Protein attributes for AMIGO1 Gene

    Size:
    493 amino acids
    Molecular mass:
    55239 Da
    Quaternary structure:
    • Homodimer, and heterodimer with AMIGO2 and AMIGO3. Interacts with KCNB1.

neXtProt entry for AMIGO1 Gene

Proteomics data for AMIGO1 Gene at MOPED

Post-translational modifications for AMIGO1 Gene

  • Glycosylation at Asn 72, Asn 264, Asn 315, Asn 349, and Asn 360
  • Modification sites at PhosphoSitePlus

Other Protein References for AMIGO1 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for AMIGO1 Gene

Domains & Families for AMIGO1 Gene

Gene Families for AMIGO1 Gene

Suggested Antigen Peptide Sequences for AMIGO1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q86WK6

UniProtKB/Swiss-Prot:

AMGO1_HUMAN :
  • The LRR repeat region mediates homodimerization.
  • Belongs to the immunoglobulin superfamily. AMIGO family.
  • Contains 6 LRR (leucine-rich) repeats.
Domain:
  • The LRR repeat region mediates homodimerization.
  • Contains 1 Ig-like C2-type (immunoglobulin-like) domain.
  • Contains 1 LRRCT domain.
  • Contains 1 LRRNT domain.
Family:
  • Belongs to the immunoglobulin superfamily. AMIGO family.
Similarity:
  • Contains 6 LRR (leucine-rich) repeats.
genes like me logo Genes that share domains with AMIGO1: view

Function for AMIGO1 Gene

Molecular function for AMIGO1 Gene

UniProtKB/Swiss-Prot Function:
Promotes growth and fasciculation of neurites from cultured hippocampal neurons. May be involved in fasciculation as well as myelination of developing neural axons. May have a role in regeneration as well as neural plasticity in the adult nervous system. May mediate homophilic as well as heterophilic cell-cell interaction and contribute to signal transduction through its intracellular domain. Assembled with KCNB1 modulates the gating characteristics of the delayed rectifier voltage-dependent potassium channel KCNB1.

Phenotypes for AMIGO1 Gene

genes like me logo Genes that share phenotypes with AMIGO1: view

Animal Model Products

miRNA for AMIGO1 Gene

miRTarBase miRNAs that target AMIGO1

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for AMIGO1 Gene

Localization for AMIGO1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for AMIGO1 Gene

Cell membrane; Single-pass type I membrane protein. Perikaryon. Cell projection, dendrite. Cell projection, axon. Note=Colocalizes with KCNB1 at high-density somatodendritic clusters on the surface of hippocampal and cortical neurons. Associated with axons of neuronal cells. {ECO:0000250 UniProtKB:Q80ZD7, ECO:0000250 UniProtKB:Q80ZD8}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for AMIGO1 Gene COMPARTMENTS Subcellular localization image for AMIGO1 gene
Compartment Confidence
plasma membrane 5
cytosol 1
lysosome 1
peroxisome 1
vacuole 1

Gene Ontology (GO) - Cellular Components for AMIGO1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0030425 dendrite ISS --
GO:0043204 perikaryon IEA --
genes like me logo Genes that share ontologies with AMIGO1: view

Pathways & Interactions for AMIGO1 Gene

SuperPathways for AMIGO1 Gene

No Data Available

Interacting Proteins for AMIGO1 Gene

Gene Ontology (GO) - Biological Process for AMIGO1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007409 axonogenesis IEA --
GO:0042552 myelination ISS 12629050
GO:0050772 positive regulation of axonogenesis ISS 12629050
GO:0051965 positive regulation of synapse assembly IEA --
genes like me logo Genes that share ontologies with AMIGO1: view

No data available for Pathways by source and SIGNOR curated interactions for AMIGO1 Gene

Drugs & Compounds for AMIGO1 Gene

No Compound Related Data Available

Transcripts for AMIGO1 Gene

mRNA/cDNA for AMIGO1 Gene

Unigene Clusters for AMIGO1 Gene

Adhesion molecule with Ig-like domain 1:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for AMIGO1 Gene

No ASD Table

Relevant External Links for AMIGO1 Gene

GeneLoc Exon Structure for
AMIGO1
ECgene alternative splicing isoforms for
AMIGO1

Expression for AMIGO1 Gene

mRNA expression in normal human tissues for AMIGO1 Gene

Protein differential expression in normal tissues from HIPED for AMIGO1 Gene

This gene is overexpressed in Pancreatic juice (45.7) and Frontal cortex (23.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MOPED, and MaxQB for AMIGO1 Gene



SOURCE GeneReport for Unigene cluster for AMIGO1 Gene Hs.726479

genes like me logo Genes that share expression patterns with AMIGO1: view

Protein tissue co-expression partners for AMIGO1 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for AMIGO1 Gene

Orthologs for AMIGO1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for AMIGO1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia AMIGO1 35
  • 92.8 (n)
  • 95.76 (a)
AMIGO1 36
  • 95 (a)
OneToOne
dog
(Canis familiaris)
Mammalia AMIGO1 35
  • 92.09 (n)
  • 95.54 (a)
AMIGO1 36
  • 96 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Amigo1 35
  • 87.8 (n)
  • 89.63 (a)
Amigo1 16
Amigo1 36
  • 90 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia AMIGO1 35
  • 99.93 (n)
  • 100 (a)
AMIGO1 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Amigo1 35
  • 87.83 (n)
  • 89.45 (a)
oppossum
(Monodelphis domestica)
Mammalia AMIGO1 36
  • 75 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia AMIGO1 36
  • 57 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia AMIGO1 36
  • 58 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia amigo1 35
  • 60.53 (n)
  • 59.31 (a)
zebrafish
(Danio rerio)
Actinopterygii amigo1 35
  • 59.7 (n)
  • 56.68 (a)
amigo1 36
  • 54 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 26 (a)
OneToMany
Species with no ortholog for AMIGO1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for AMIGO1 Gene

ENSEMBL:
Gene Tree for AMIGO1 (if available)
TreeFam:
Gene Tree for AMIGO1 (if available)

Paralogs for AMIGO1 Gene

Paralogs for AMIGO1 Gene

(3) SIMAP similar genes for AMIGO1 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with AMIGO1: view

Variants for AMIGO1 Gene

Sequence variations from dbSNP and Humsavar for AMIGO1 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs14184 -- 109,504,488(+) TCTGT(C/G)TCCAG utr-variant-3-prime
rs575113 -- 109,503,751(-) gaggc(C/T)gagac downstream-variant-500B
rs1009437 -- 109,504,711(+) TCTTG(A/G)TAGGG utr-variant-3-prime
rs2570972 -- 109,509,517(+) CGCCC(A/G)CCTTA utr-variant-5-prime
rs3738772 -- 109,505,814(+) GAGAC(A/C)CTAAG utr-variant-3-prime

Variation tolerance for AMIGO1 Gene

Residual Variation Intolerance Score: 27.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.42; 42.76% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for AMIGO1 Gene

HapMap Linkage Disequilibrium report
AMIGO1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for AMIGO1 Gene

Disorders for AMIGO1 Gene

Relevant External Links for AMIGO1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
AMIGO1

No disorders were found for AMIGO1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for AMIGO1 Gene

Publications for AMIGO1 Gene

  1. AMIGO, a transmembrane protein implicated in axon tract development, defines a novel protein family with leucine-rich repeats. (PMID: 12629050) Kuja-Panula J. … Rauvala H. (J. Cell Biol. 2003) 2 3 4 23 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  3. New loci associated with kidney function and chronic kidney disease. (PMID: 20383146) KAPttgen A. … Fox C.S. (Nat. Genet. 2010) 3
  4. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PMID: 17207965) Lamesch P. … Vidal M. (Genomics 2007) 3
  5. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory S.G. … Bentley D.R. (Nature 2006) 3

Products for AMIGO1 Gene

Sources for AMIGO1 Gene

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