AMIGO1 Gene
protein-coding GIFtS: 47
GCID: GC01M110046
|
|
adhesion molecule with Ig-like domain 1
| |
Aliases
for AMIGO1 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Adhesion Molecule With Ig-Like Domain 11 2 | | Amphoterin-Induced Gene And ORF2 | | AMIGO1 2 3 | | Amphoterin-Induced Protein 12 | | KIAA11631 3 | | ALI23 | | AMIGO-12 3 | | Alivin-23 | | Alivin-23 | | |
Export aliases for AMIGO1 gene to outside databasesPrevious GC identifers: GC01M109763 GC01M109848 GC01M107942 |
Summaries
for AMIGO1 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: AMGO1_HUMAN, Q86WK6Function: Promotes growth and fasciculation of neurites from cultured hippocampal neurons. May be involved infasciculation as well as myelination of developing neural axons. May have a role in regeneration as well as neuralplasticity in the adult nervous system. May mediate homophilic as well as heterophilic cell-cell interaction andcontribute to signal transduction through its intracellular domain (By similarity)
|
Genomic Views
for AMIGO1 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000001.10 NC_018912.1 NT_032977.9
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the AMIGO1 gene promoter:
AP-4 NF-kappaB E47 C/EBPalpha Egr-2 CHOP-10 c-Myb Chx10 NF-kappaB1 Pax-4a
Other transcription factors
Search SABiosciences Chromatin IP Primers for AMIGO1
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat AMIGO1 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 1p13.3 Ensembl cytogenetic band: 1p13.3 HGNC cytogenetic band: 1p13.3AMIGO1 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 1 GeneLoc Exon Structure GeneLoc location for GC01M110046: view genomic region
(about GC identifiers)
Start:
|
110,046,797 bp from pter |
End:
|
110,052,360 bp from pter |
Size:
|
5,564 bases |
Orientation:
|
minus strand |
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Proteins
for AMIGO1 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: AMGO1_HUMAN, Q86WK6 (See
protein sequence)Recommended Name: Amphoterin-induced protein 1 precursor Size: 493 amino acids; 55239 Da
Subunit: Homodimer, and heterodimer with AMIGO2 and AMIGO3 (By similarity)
Subcellular location: Cell membrane; Single-pass type I membrane protein (By similarity). Cell projection, axon (Bysimilarity). Note=Associated with axons of neuronal cells (By similarity)
Secondary accessions: B4DIM3 Q8IW71 Q9ULQ7Explore the universe of human proteins at neXtProt for AMIGO1: NX_Q86WK6
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q86WK6
AMIGO1 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_065754.2
ENSEMBL proteins: ENSP00000358880 ENSP00000358878
Human Recombinant Protein Products:
Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table
AMIGO1 for ontologies About GeneDecksing
AMIGO1 Antibody Products:
Assay Products for AMIGO1: |
Protein
Domains /
Families
for AMIGO1 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
AMIGO1 for domains About GeneDecksing
5/8 InterPro domains/families (see all 8):Graphical View of Domain Structure for InterPro Entry Q86WK6ProtoNet protein and cluster: Q86WK6 3 Blocks protein families: IPB000483 Cysteine-rich flanking region IPB001611 Leucine-rich repeat signature IPB003599 Immunoglobulin subtype
UniProtKB/Swiss-Prot: AMGO1_HUMAN, Q86WK6Domain: The LRR repeat region mediates homodimerization (By similarity)Similarity: Belongs to the immunoglobulin superfamily. AMIGO familySimilarity: Contains 1 Ig-like C2-type (immunoglobulin-like) domainSimilarity: Contains 6 LRR (leucine-rich) repeatsSimilarity: Contains 1 LRRCT domainSimilarity: Contains 1 LRRNT domain |
Function
for AMIGO1 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: AMGO1_HUMAN, Q86WK6Function: Promotes growth and fasciculation of neurites from cultured hippocampal neurons. May be involved infasciculation as well as myelination of developing neural axons. May have a role in regeneration as well as neuralplasticity in the adult nervous system. May mediate homophilic as well as heterophilic cell-cell interaction andcontribute to signal transduction through its intracellular domain (By similarity)
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for AMIGO1 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for AMIGO1 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
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In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for AMIGO1 |
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005515 | protein binding |
-- | -- |
AMIGO1 for ontologies About GeneDecksing
1 GenomeRNAi human phenotype for AMIGO1:
|
Pathways & Interactions
for AMIGO1 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for AMIGO1
STRING Interaction
Network Preview (showing 2 interactants - click image to see more details)
2 Interacting proteins for AMIGO1 (Q86WK63 ENSP000003588784) via UniProtKB, MINT, STRING, and/or I2DAbout this table
Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6): About this table
AMIGO1 for ontologies About GeneDecksing
|
Drugs & Compounds
for AMIGO1 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for AMIGO1
Search CenterWatch for drugs/clinical trials and news about AMIGO1 / AMGO1
|
Transcripts
for AMIGO1 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for AMIGO1 gene: NM_020703.2 Unigene Cluster for AMIGO1: Adhesion molecule with Ig-like domain 1 Hs.726479 [show with all ESTs]Unigene Representative Sequence: AB0329892 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000369864(uc001dxx.4) ENST00000369862
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for AMIGO1 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for AMIGO1 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: AMIGO1 (NM_020703) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for AMIGO1 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat AMIGO1 |
Additional cDNA sequence: AB032989.1 AK295678.1 AY237007.1 BC040879.1 1 DOTS entry: DT.315590 24/97 AceView cDNA sequences (see all 97): AI565242 BU628240 BC040879 AI392736 BG056176 BI831752 CA393641 AW205224 F03441 BE348609 AW135785 AI183455 BQ636819 BM714965 AY237007 BE465139 BU742472 AB032989 BU674353 BM465762 H86485 BF364824 BM142083 BM717042
GeneLoc Exon Structure
|
Expression
for AMIGO1 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| AMIGO1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TCTCCCAGGA
About this image
See AMIGO1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for AMIGO1
SOURCE GeneReport for Unigene cluster: Hs.726479
SABiosciences Custom PCR Arrays for AMIGO1
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for AMIGO1
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat AMIGO1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat AMIGO1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat AMIGO1 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for AMIGO1 |
Orthologs
for AMIGO1 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for AMIGO1 gene from 2/9 species (see all 9) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
lizard
(Anolis carolinensis) |
Reptilia |
AMIGO16 |
-- |
58(a) |
1 ↔ 1 |
4(105650469-105651851) |
zebrafish
(Danio rerio) |
Actinopterygii |
amigo11 |
adhesion molecule with Ig-like domain 1 |
59.73(n)
56.48(a) |
|
100144409 XM_001923988.3 XP_001924023.1 |
ENSEMBL Gene Tree for AMIGO1 (if available)
TreeFam Gene Tree for AMIGO1 (if available) |
Paralogs
for AMIGO1 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for AMIGO1 gene
- AMIGO22 AMIGO32
3 SIMAP similar genes for AMIGO1 using alignment to 1 protein entry: AMGO1_HUMAN:AMIGO2 DCN AMIGO3
AMIGO1 for paralogs About GeneDecksing
|
Genomic Variants
for AMIGO1 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 1 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for AMIGO1 (110046797 - 110052360 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for AMIGO1: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing AMIGO1 |
|
Disorders
/ Diseases
for AMIGO1 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
AMIGO1 for disorders About GeneDecksing
3  diseases for AMIGO1: About MalaCardspthirus pubis infestation kidney disease neuronitis
Export disorders for AMIGO1 gene to outside databases
|
Publications
for AMIGO1 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for AMIGO1 gene integrated from 9 sources:
(articles sorted by number of sources associating them with AMIGO1) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- AMIGO, a transmembrane protein implicated in axon tract development, defines a novel protein family with leucine-rich repeats. (PubMed id 12629050)1, 2, 3, 9 Kuja-Panula J....Rauvala H. (2003)
- The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (2006)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Characterization of cDNA clones selected by the GeneMark analysis from size-fractionated cDNA libraries from human brain. (PubMed id 10574461)1, 2 Hirosawa M.... Ohara O. (1999)
- New loci associated with kidney function and chronic kidney disease. (PubMed id 20383146)1 KAPttgen A....Fox C.S. (2010)
- A quantitative atlas of mitotic phosphorylation. (PubMed id 18669648)2 Dephoure N.... Gygi S.P. (2008)
- hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965)1 Lamesch P.... Vidal M. (2007)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)2 Ota T.... Sugano S. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
|
External Searches for AMIGO1 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing AMIGO1 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing AMIGO1 gene
(According to HUGE)
About This Section
| |
Specialized Databases showing AMIGO1 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for AMIGO1 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for AMIGO1 gene:
Search GeneIP for patents involving AMIGO1
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for AMIGO1 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat AMIGO1 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing AMIGO1 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat AMIGO1 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat AMIGO1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat AMIGO1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat AMIGO1 |
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 | | | AMIGO1 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for AMIGO1 |
|  |  |  | | | | Search ThermoFisher Antibodies for AMIGO1 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat AMIGO1 |
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