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Aliases for AMIGO1 Gene

Aliases for AMIGO1 Gene

  • Adhesion Molecule With Ig Like Domain 1 2 3 5
  • Alivin-2 3 4
  • AMIGO-1 3 4
  • AMIGO 3 4
  • ALI2 3 4
  • Amphoterin-Induced Gene And Open Reading Frame 2
  • Amphoterin-Induced Gene And ORF 3
  • Amphoterin-Induced Protein 1 3
  • KIAA1163 4

External Ids for AMIGO1 Gene

Previous GeneCards Identifiers for AMIGO1 Gene

  • GC01M109763
  • GC01M109848
  • GC01M110046
  • GC01M107942

Summaries for AMIGO1 Gene

GeneCards Summary for AMIGO1 Gene

AMIGO1 (Adhesion Molecule With Ig Like Domain 1) is a Protein Coding gene. An important paralog of this gene is AMIGO2.

UniProtKB/Swiss-Prot for AMIGO1 Gene

  • Promotes growth and fasciculation of neurites from cultured hippocampal neurons. May be involved in fasciculation as well as myelination of developing neural axons. May have a role in regeneration as well as neural plasticity in the adult nervous system. May mediate homophilic as well as heterophilic cell-cell interaction and contribute to signal transduction through its intracellular domain. Assembled with KCNB1 modulates the gating characteristics of the delayed rectifier voltage-dependent potassium channel KCNB1.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for AMIGO1 Gene

Genomics for AMIGO1 Gene

Regulatory Elements for AMIGO1 Gene

Enhancers for AMIGO1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01F109508 0.8 ENCODE 63.6 +0.2 242 1.5 CREB3L1 ZNF76 ARID4B SIN3A ZNF2 ZEB1 ELK1 EGR1 ZNF366 KLF13 AMIGO1 ENSG00000235005 ENSG00000232971 PIR54880
GH01F109527 1 Ensembl ENCODE 49.5 -21.0 -20990 5.7 HDGF PKNOX1 CREB3L1 ZNF133 SIN3A ARID4B ZNF2 ZNF121 GLIS2 ELK1 AMIGO1 CELSR2 LOC105378893 GPR61
GH01F109497 1 Ensembl ENCODE 31.3 +9.3 9252 6.0 HDGF CTCF PKNOX1 MAX ZMYM3 ZIC2 RAD21 ZFHX2 ZNF366 POLR2A AMIGO1 SYPL2 GPR61 ENSG00000254942 GC01M109507 CYB561D1 PIR48461
GH01F109465 0.5 ENCODE 28.6 +42.6 42563 2.8 PKNOX1 ZNF76 RAD21 YY1 GLIS2 ZNF366 KLF7 EGR2 ZNF263 ZNF680 SYPL2 AMIGO1 ATXN7L2
GH01F109423 1.2 ENCODE 23.8 +84.1 84078 4.8 HDGF PKNOX1 CREB3L1 MLX WRNIP1 ARID4B SIN3A DMAP1 ZNF2 YY1 SYPL2 AMIGO1 GNAI3 GSTM5 ENSG00000258634 GSTM3 ATXN7L2 GC01M109421 PSMA5
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around AMIGO1 on UCSC Golden Path with GeneCards custom track

Promoters for AMIGO1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000284342 138 1201 CREB3L1 ZNF76 ARID4B SIN3A ZNF2 ZEB1 ELK1 EGR1 ZNF366 KLF13

Genomic Location for AMIGO1 Gene

Chromosome:
1
Start:
109,504,175 bp from pter
End:
109,509,738 bp from pter
Size:
5,564 bases
Orientation:
Minus strand

Genomic View for AMIGO1 Gene

Genes around AMIGO1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
AMIGO1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for AMIGO1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for AMIGO1 Gene

Proteins for AMIGO1 Gene

  • Protein details for AMIGO1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q86WK6-AMGO1_HUMAN
    Recommended name:
    Amphoterin-induced protein 1
    Protein Accession:
    Q86WK6
    Secondary Accessions:
    • B4DIM3
    • Q8IW71
    • Q9ULQ7

    Protein attributes for AMIGO1 Gene

    Size:
    493 amino acids
    Molecular mass:
    55239 Da
    Quaternary structure:
    • Homodimer, and heterodimer with AMIGO2 and AMIGO3. Interacts with KCNB1.

neXtProt entry for AMIGO1 Gene

Post-translational modifications for AMIGO1 Gene

  • Glycosylation at Asn 72, Asn 264, Asn 315, Asn 349, and Asn 360
  • Modification sites at PhosphoSitePlus

Other Protein References for AMIGO1 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Abcam antibodies for AMIGO1
  • Cloud-Clone Corp. Antibodies for AMIGO1

No data available for DME Specific Peptides for AMIGO1 Gene

Domains & Families for AMIGO1 Gene

Gene Families for AMIGO1 Gene

Suggested Antigen Peptide Sequences for AMIGO1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q86WK6

UniProtKB/Swiss-Prot:

AMGO1_HUMAN :
  • The LRR repeat region mediates homodimerization.
  • Belongs to the immunoglobulin superfamily. AMIGO family.
  • Contains 6 LRR (leucine-rich) repeats.
Domain:
  • The LRR repeat region mediates homodimerization.
  • Contains 1 Ig-like C2-type (immunoglobulin-like) domain.
  • Contains 1 LRRCT domain.
  • Contains 1 LRRNT domain.
Family:
  • Belongs to the immunoglobulin superfamily. AMIGO family.
Similarity:
  • Contains 6 LRR (leucine-rich) repeats.
genes like me logo Genes that share domains with AMIGO1: view

Function for AMIGO1 Gene

Molecular function for AMIGO1 Gene

UniProtKB/Swiss-Prot Function:
Promotes growth and fasciculation of neurites from cultured hippocampal neurons. May be involved in fasciculation as well as myelination of developing neural axons. May have a role in regeneration as well as neural plasticity in the adult nervous system. May mediate homophilic as well as heterophilic cell-cell interaction and contribute to signal transduction through its intracellular domain. Assembled with KCNB1 modulates the gating characteristics of the delayed rectifier voltage-dependent potassium channel KCNB1.

Gene Ontology (GO) - Molecular Function for AMIGO1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0015459 potassium channel regulator activity ISS --
genes like me logo Genes that share ontologies with AMIGO1: view

Phenotypes for AMIGO1 Gene

genes like me logo Genes that share phenotypes with AMIGO1: view

Animal Model Products

miRNA for AMIGO1 Gene

miRTarBase miRNAs that target AMIGO1

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for AMIGO1 Gene

Localization for AMIGO1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for AMIGO1 Gene

Cell membrane; Single-pass type I membrane protein. Perikaryon. Cell projection, dendrite. Cell projection, axon. Note=Colocalizes with KCNB1 at high-density somatodendritic clusters on the surface of hippocampal and cortical neurons. Associated with axons of neuronal cells. {ECO:0000250 UniProtKB:Q80ZD7, ECO:0000250 UniProtKB:Q80ZD8}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for AMIGO1 Gene COMPARTMENTS Subcellular localization image for AMIGO1 gene
Compartment Confidence
plasma membrane 5
cytosol 1
lysosome 1
peroxisome 1
vacuole 1

Gene Ontology (GO) - Cellular Components for AMIGO1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005887 integral component of plasma membrane IEA --
GO:0008076 colocalizes_with voltage-gated potassium channel complex ISS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0030424 axon IEA --
genes like me logo Genes that share ontologies with AMIGO1: view

Pathways & Interactions for AMIGO1 Gene

SuperPathways for AMIGO1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for AMIGO1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007155 cell adhesion IEA --
GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules ISS 12629050
GO:0007157 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules ISS 12629050
GO:0007275 multicellular organism development IEA --
GO:0007399 nervous system development IEA --
genes like me logo Genes that share ontologies with AMIGO1: view

No data available for Pathways by source and SIGNOR curated interactions for AMIGO1 Gene

Transcripts for AMIGO1 Gene

mRNA/cDNA for AMIGO1 Gene

Unigene Clusters for AMIGO1 Gene

Adhesion molecule with Ig-like domain 1:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for AMIGO1 Gene

No ASD Table

Relevant External Links for AMIGO1 Gene

GeneLoc Exon Structure for
AMIGO1
ECgene alternative splicing isoforms for
AMIGO1

Expression for AMIGO1 Gene

mRNA expression in normal human tissues for AMIGO1 Gene

Protein differential expression in normal tissues from HIPED for AMIGO1 Gene

This gene is overexpressed in Pancreatic juice (45.7) and Frontal cortex (23.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for AMIGO1 Gene



Protein tissue co-expression partners for AMIGO1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of AMIGO1 Gene:

AMIGO1

SOURCE GeneReport for Unigene cluster for AMIGO1 Gene:

Hs.726479
genes like me logo Genes that share expression patterns with AMIGO1: view

Primer Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for AMIGO1 Gene

Orthologs for AMIGO1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for AMIGO1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia AMIGO1 34 35
  • 99.93 (n)
cow
(Bos Taurus)
Mammalia AMIGO1 34 35
  • 92.8 (n)
dog
(Canis familiaris)
Mammalia AMIGO1 34 35
  • 92.09 (n)
rat
(Rattus norvegicus)
Mammalia Amigo1 34
  • 87.83 (n)
mouse
(Mus musculus)
Mammalia Amigo1 34 16 35
  • 87.8 (n)
oppossum
(Monodelphis domestica)
Mammalia AMIGO1 35
  • 75 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia AMIGO1 35
  • 57 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia AMIGO1 35
  • 58 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia amigo1 34
  • 60.53 (n)
zebrafish
(Danio rerio)
Actinopterygii amigo1 34 35
  • 59.7 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 26 (a)
OneToMany
Species where no ortholog for AMIGO1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for AMIGO1 Gene

ENSEMBL:
Gene Tree for AMIGO1 (if available)
TreeFam:
Gene Tree for AMIGO1 (if available)

Paralogs for AMIGO1 Gene

Paralogs for AMIGO1 Gene

(3) SIMAP similar genes for AMIGO1 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with AMIGO1: view

Variants for AMIGO1 Gene

Sequence variations from dbSNP and Humsavar for AMIGO1 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs1009437 -- 109,504,711(+) TCTTG(A/G)TAGGG utr-variant-3-prime
rs11101965 -- 109,511,112(+) GGCAC(C/G)CACCT upstream-variant-2KB
rs111231259 -- 109,510,187(+) GGGTT(-/C)CCCCC upstream-variant-2KB
rs112000174 -- 109,507,284(+) GGGTC(C/T)TGCTC utr-variant-3-prime
rs112488919 -- 109,511,561(+) ATGCA(A/G)TTATG upstream-variant-2KB

Variation tolerance for AMIGO1 Gene

Residual Variation Intolerance Score: 27.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.42; 42.76% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for AMIGO1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
AMIGO1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for AMIGO1 Gene

Disorders for AMIGO1 Gene

Relevant External Links for AMIGO1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
AMIGO1

No disorders were found for AMIGO1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for AMIGO1 Gene

Publications for AMIGO1 Gene

  1. AMIGO, a transmembrane protein implicated in axon tract development, defines a novel protein family with leucine-rich repeats. (PMID: 12629050) Kuja-Panula J. … Rauvala H. (J. Cell Biol. 2003) 2 3 4 22 64
  2. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory S.G. … Bentley D.R. (Nature 2006) 3 4 64
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  4. Characterization of cDNA clones selected by the GeneMark analysis from size-fractionated cDNA libraries from human brain. (PMID: 10574461) Hirosawa M. … Ohara O. (DNA Res. 1999) 3 4 64
  5. AMIGO-Kv2.1 Potassium Channel Complex Is Associated With Schizophrenia-Related Phenotypes. (PMID: 26240432) Peltola M.A. … Rauvala H. (Schizophr Bull 2016) 3 64

Products for AMIGO1 Gene

Sources for AMIGO1 Gene

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