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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

AMICA1 Gene

protein-coding   GIFtS: 55
GCID: GC11M118064

Adhesion Molecule, Interacts With CXADR Antigen 1

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Adhesion Molecule, Interacts With CXADR Antigen 11 2     Gm6382
JAML2 3 5     Adhesion Molecule AMICA2
Adhesion Molecule Interacting With CXADR Antigen 12 3     Adhesion Molecule That Interacts With CXADR Antigen 12
Dendritic Cell-Specific Protein CREA7-12 3     Dendritic-Cell Specific Protein CREA7-12
AMICA2     Dendritic-Cell Specific Protein CREA7-42
CREA7-12     Junctional Adhesion Molecule2
CREA7-42     Junctional Adhesion Molecule-Like2

External Ids:    HGNC: 190841   Entrez Gene: 1204252   Ensembl: ENSG000001605937   OMIM: 6097705   UniProtKB: Q86YT93   

Export aliases for AMICA1 gene to outside databases

Previous GC identifers: GC00U991274 GC11M117570 GC11M113998


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for AMICA1 Gene: 
AMICA1 (adhesion molecule, interacts with CXADR antigen 1) is a protein-coding gene. Diseases associated with AMICA1 include endotheliitis, and myeloid leukemia, and among its related super-pathways are Immune System and Signaling by GPCR. GO annotations related to this gene include cell adhesion molecule binding.

UniProtKB/Swiss-Prot: JAML1_HUMAN, Q86YT9
Function: May function in transmigration of leukocytes through epithelial and endothelial tissues. Expressed at
the plasma membrane of polymorphonuclear leukocytes, it mediates adhesive interactions with CXADR, a protein of
the junctional complex of epithelial cells. Enhances myeloid leukemia cell adhesion to endothelial cells

Gene Wiki entry for AMICA1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000011.9  NT_033899.8  NC_018922.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the AMICA1 gene promoter:
         AML1a   FOXO4   ARP-1   Msx-1   Cdc5   C/EBPalpha   Hlf   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidAMICA1 promoter sequence
   Search SABiosciences Chromatin IP Primers for AMICA1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat AMICA1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q23.3   Ensembl cytogenetic band:  11q23.3   HGNC cytogenetic band: 11q23.3

AMICA1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
AMICA1 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11M118064:  view genomic region     (about GC identifiers)

Start:
118,064,442 bp from pter      End:
118,095,809 bp from pter
Size:
31,368 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: JAML1_HUMAN, Q86YT9 (See protein sequence)
Recommended Name: Junctional adhesion molecule-like precursor  
Size: 394 amino acids; 44339 Da
Subunit: Interacts with CXADR, the interaction results in intracellular recruitment of PI3K followed by
phosphorylation at Tyr-361 (By similarity)
Subcellular location: Cell junction. Cell membrane; Single-pass type I membrane protein. Note=Localized at the
plasma membrane in areas of cell-cell contacts and at the cell surface of PMN
Sequence caution: Sequence=BAC03390.1; Type=Erroneous initiation;
Secondary accessions: B0YIV1 B0YIV2 Q5DTC6 Q7Z499 Q8N9I7 Q8NF70
Alternative splicing: 3 isoforms:  Q86YT9-1   Q86YT9-2   Q86YT9-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for AMICA1: NX_Q86YT9

Explore proteomics data for AMICA1 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q86YT9

  • AMICA1 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    AMICA1 Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_001091996.1  NP_694938.2  

    ENSEMBL proteins: 
     ENSP00000348635   ENSP00000292067   ENSP00000436117   ENSP00000431614   ENSP00000431218  
     ENSP00000432769   ENSP00000435145   ENSP00000431791  
    Reactome Protein details: Q86YT9
    Human Recombinant Protein Products for AMICA1: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    R&D Systems Recombinant & Natural Proteins for AMICA1 (AMICA/JAML)
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for AMICA1
    OriGene Custom MassSpec 
    OriGene Custom Protein Services for AMICA1
    GenScript Custom Purified and Recombinant Proteins Services for AMICA1
    Novus Biologicals AMICA1 Protein
    Novus Biologicals AMICA1 Lysates
    Sino Biological Recombinant Protein for AMICA1
    Sino Biological Cell Lysate for AMICA1 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for AMICA1 

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0005923tight junction IDA15800062
    GO:0016021integral to membrane IEA--

    AMICA1 for ontologies           About GeneDecksing



    AMICA1 Antibody Products: 
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    Novus Biologicals AMICA1 Antibodies
    Abcam antibodies for AMICA1
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    LSBio Antibodies in human, mouse, rat for AMICA1 

    Assay Products for AMICA1: 
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    Cloud-Clone Corp. ELISAs for AMICA1 
    Cloud-Clone Corp. CLIAs for AMICA1


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    VSET: Immunoglobulin superfamily / V-set domain containing

    4 InterPro protein domains:
     IPR007110 Ig-like_dom
     IPR003599 Ig_sub
     IPR013783 Ig-like_fold
     IPR013106 Ig_V-set

    Graphical View of Domain Structure for InterPro Entry Q86YT9

    ProtoNet protein and cluster: Q86YT9

    1 Blocks protein domain: IPB013106 Immunoglobulin V-set

    UniProtKB/Swiss-Prot: JAML1_HUMAN, Q86YT9
    Domain: The Ig-like V-type domain 2 mediates interaction with CXADR
    Similarity: Belongs to the immunoglobulin superfamily
    Similarity: Contains 2 Ig-like V-type (immunoglobulin-like) domains


    AMICA1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: JAML1_HUMAN, Q86YT9
    Function: May function in transmigration of leukocytes through epithelial and endothelial tissues. Expressed at
    the plasma membrane of polymorphonuclear leukocytes, it mediates adhesive interactions with CXADR, a protein of
    the junctional complex of epithelial cells. Enhances myeloid leukemia cell adhesion to endothelial cells
    Induction: Up-regulated upon retinoic acid, Me2SO and PMA treatment in differentiating myeloid leukemia cells

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
    GO:0050839cell adhesion molecule binding IPI15800062
         
    AMICA1 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for AMICA1:
     Decreased viability of wild-ty  Increased HPV18 LCR reporter a 

         1 MGI phenotypic allele for Amica1 (no phenotypes)

    AMICA1 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Amica1tm1Lex for AMICA1

       inGenious Targeting Laboratory - Custom generated mouse model solutions for AMICA1 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for AMICA1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for AMICA1 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for AMICA1 

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat AMICA1
    1 QIAGEN miScript miRNA Assays for microRNA that regulate AMICA1:
    hsa-miR-3692
    SwitchGear 3'UTR luciferase reporter plasmidAMICA1 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
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    Gene Editing
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    GenScript: all cDNA clones in your preferred vector (see all 2): AMICA1 (NM_001098526)
    Sino Biological Human cDNA Clone for AMICA1
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for AMICA1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat AMICA1
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                         Customized lentivirus expression plasmids for stable overexpression of AMICA1 

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for AMICA1


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for AMICA1 About   (see all 6)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Immune System
    Immune System0.56
    Adaptive Immune System0.56
    2Signaling by GPCR
    Signal Transduction0.55
    3Platelet activation, signaling and aggregation
    Hemostasis0.43
    4Non-integrin membrane-ECM interactions
    Integrin cell surface interactions0.32
    5Classical antibody-mediated complement activation
    Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell0.30

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    5/7        Reactome Pathways for AMICA1 (see all 7)
        Hemostasis
    Integrin cell surface interactions
    Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
    Signal Transduction
    Adaptive Immune System



    AMICA1 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for AMICA1

    STRING Interaction Network Preview (showing 5 interactants - click image to see more details)

    5 Interacting proteins for AMICA1 (ENSP000003486354) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ITGA4ENSP000003802274STRING: ENSP00000380227
    ITGAXENSP000002682964STRING: ENSP00000268296
    ITGB2ENSP000003032424STRING: ENSP00000303242
    ITGB1ENSP000003640944STRING: ENSP00000364094
    CXADRENSP000002848784STRING: ENSP00000284878
    About this table

    Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007157heterophilic cell-cell adhesion IDA15800062
    GO:0007596blood coagulation TAS--
    GO:0030593neutrophil chemotaxis IMP15800062
    GO:0050776regulation of immune response TAS--
    GO:0050900leukocyte migration TAS--

    AMICA1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for AMICA1 (JAML1)

    Search CenterWatch for drugs/clinical trials and news about AMICA1 / JAML1

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for AMICA1 gene (2 alternative transcripts): 
    NM_001098526.1  NM_153206.2  

    Unigene Cluster for AMICA1:

    Adhesion molecule, interacts with CXADR antigen 1
    Hs.16291  [show with all ESTs]
    Unigene Representative Sequence: AK090409
    12 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000356289(uc001psh.2 uc009yzw.1 uc001psk.2 uc010rxw.1)
    ENST00000292067(uc001psi.2) ENST00000534294(uc010rxx.1) ENST00000533261
    ENST00000526595(uc001psl.1) ENST00000531530(uc001psg.2) ENST00000526620
    ENST00000529164 ENST00000531536 ENST00000524477 ENST00000527877 ENST00000525565

    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat AMICA1
    1 QIAGEN miScript miRNA Assays for microRNA that regulate AMICA1:
    hsa-miR-3692
    SwitchGear 3'UTR luciferase reporter plasmidAMICA1 3' UTR sequence
    Inhib. RNA
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    OriGene ORF clones in mouse, rat for AMICA1
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    GenScript: all cDNA clones in your preferred vector (see all 2): AMICA1 (NM_001098526)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for AMICA1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat AMICA1
    Sirion Biotech Customized lentivirus for stable overexpression of AMICA1 
                         Customized lentivirus expression plasmids for stable overexpression of AMICA1 
    Primer
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    OriGene qSTAR qPCR primer pairs in human, mouse for AMICA1
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat AMICA1
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat AMICA1
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat AMICA1

    Additional mRNA sequence: 

    AJ515553.2 AK057581.1 AK057590.1 AK090409.1 AK094399.1 AK097285.1 AK298722.1 AK300851.1 
    AK301099.1 AY093686.1 AY093687.1 AY138965.1 AY358362.1 BC100794.2 BC100795.2 BC100796.1 
    BC100797.1 

    12 DOTS entries:

    DT.101982016  DT.99998898  DT.95263479  DT.99936254  DT.109017  DT.101961445  DT.95166066  DT.95166068 
    DT.120705906  DT.120705907  DT.100702098  DT.100738912 

    24/89 AceView cDNA sequences (see all 89):

    AI291283 CA444312 BM983629 AI088612 AL546758 CF541186 CR611880 CD366178 
    BF002780 AY138965 CR598736 AW501105 C01482 AI871971 AI354980 AK090409 
    CA306656 CR596683 BQ184892 AV647457 AI800408 CF121828 CB528873 AW500962 

    GeneLoc Exon Structure

    5/12 Alternative Splicing Database (ASD) splice patterns (SP) for AMICA1 (see all 12)    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6a · 6b ^ 7 ^ 8a · 8b · 8c ^ 9a · 9b · 9c · 9d ^ 10 ^ 11a · 11b · 11c · 11d ^ 12 ^
    SP1:                          -           -     -     -     -                                         -                             -           -     -         
    SP2:                                                        -                                         -                             -           -     -         
    SP3:                                                  -     -                                         -                             -           -     -         
    SP4:                                                  -     -                                         -                             -                 -         
    SP5:                          -           -     -     -     -                                         -                             -                           

    ExUns: 13a · 13b · 13c
    SP1:                  
    SP2:                  
    SP3:                  
    SP4:                  
    SP5:                  


    ECgene alternative splicing isoforms for AMICA1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    AMICA1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GACTTGGCCT
    AMICA1 Expression
    About this image


    See AMICA1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for AMICA1

    SOURCE GeneReport for Unigene cluster: Hs.16291

    UniProtKB/Swiss-Prot: JAML1_HUMAN, Q86YT9
    Tissue specificity: Expression is restricted to the hematopoietic tissues with the exception of liver. Expressed
    in fetal liver, spleen and thymus

        SABiosciences Custom PCR Arrays for AMICA1
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for AMICA1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for AMICA1 gene from 2/6 species (see all 6)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Amica11 , 5 adhesion molecule, interacts with CXADR antigen 11, 5 70.33(n)1
    60.71(a)1
      9 (24.84 cM)5
    2701521  NM_001005421.41  NP_001005421.31 
     450791835 
    chicken
    (Gallus gallus)
    Aves AMICA16
    Uncharacterized protein
    25(a)
    1 ↔ 1
    24(5452747-5454564)


    ENSEMBL Gene Tree for AMICA1 (if available)
    TreeFam Gene Tree for AMICA1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for AMICA1 gene
    1 SIMAP similar gene for AMICA1 using alignment to 10 protein entries:     JAML1_HUMAN (see all proteins):
    CREA7-4

    AMICA1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/681 SNPs in AMICA1 are shown (see all 681)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1877036241,2
    --118064023(+) GATTCC/TCAGCT 2 -- ds50010--------
    rs455551321,2
    C,F--118064030(+) AGCTTG/TGTTGC 2 -- ds50013Minor allele frequency- T:0.03NS NA EA 280
    rs1910726161,2
    --118064098(+) TGCTGA/GATTCA 2 -- ds50010--------
    rs1505151511,2
    --118064245(+) CCTTAC/TCAAAT 2 -- ds50010--------
    rs1403262091,2
    --118064369(+) ACCCAA/GAAATT 2 -- ds50010--------
    rs1442897111,2
    --118064400(+) TGAGGA/CCCCGC 2 -- ds50010--------
    rs37413161,2
    C,F,H--118064530(+) TAGCAC/TGGTTT 2 -- ut317Minor allele frequency- T:0.03EA NS 2398
    rs1131757241,2
    C,F--118064531(+) AGCACG/AGTTTG 2 -- ut312Minor allele frequency- A:0.04WA 120
    rs6192501,2
    C,F,O,A,H--118064582(+) CTGTAA/C/TATTCC 4 -- ut3138NA MN NS EA WA CSA 3479
    rs775887191,2
    C,F--118064632(+) AATAGG/CACGAT 2 -- ut311Minor allele frequency- C:0.02WA 118

    HapMap Linkage Disequilibrium report for AMICA1 (118064442 - 118095809 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for AMICA1:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv511CNV Insertion18451855

    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 609770    OMIM disorders: --

    3 diseases for AMICA1:    About MalaCards
    endotheliitis    myeloid leukemia    leukemia


    AMICA1 for disorders           About GeneDecksing

    Genetic Association Database (GAD): AMICA1
    Human Genome Epidemiology (HuGE) Navigator: AMICA1 (1 document)

    Export disorders for AMICA1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for AMICA1 gene, integrated from 9 sources (see all 12):
    (articles sorted by number of sources associating them with AMICA1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2, 3 Clark H.F.... Gray A.M. (2003)
    2. JAML, a novel protein with characteristics of a junctional adhesion molecule, is induced during differentiation of myeloid leukemia cells. (PubMed id 12869515)1, 2, 9 Moog-Lutz C.... Lutz P.G. (2003)
    3. Neutrophil migration across tight junctions is mediated by adhesive interactions between epithelial CAR and a JAM-like protein on neutrophils. (PubMed id 15800062)1, 2, 9 Zen K....Parkos C.A. (2005)
    4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (2010)
    5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    6. Signal peptide prediction based on analysis of experimentally verified cleavage sites. (PubMed id 15340161)1, 2 Zhang Z. and Henzel W.J. (2004)
    7. A secreted protein microarray platform for extracellul ar protein interaction discovery. (PubMed id 21982860)1 Ramani S.R....Gonzalez L.C. (2012)
    8. JAM-L-mediated leukocyte adhesion to endothelial cells is regulated in cis by alpha4beta1 integrin activation. (PubMed id 19064666)1 Luissint A.C....Bourdoulous S. (2008)
    9. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
    10. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 120425 HGNC: 19084 AceView: AMICA Ensembl:ENSG00000160593 euGenes: HUgn120425
    ECgene: AMICA1 H-InvDB: AMICA1

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for AMICA1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for AMICA1 gene:
    Search GeneIP for patents involving AMICA1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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