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Aliases for AMICA1 Gene

Aliases for AMICA1 Gene

  • Adhesion Molecule, Interacts With CXADR Antigen 1 2 3
  • JAML 3 4 6
  • Adhesion Molecule Interacting With CXADR Antigen 1 3 4
  • Dendritic-Cell Specific Protein CREA7-1 3
  • Dendritic-Cell Specific Protein CREA7-4 3
  • Dendritic Cell-Specific Protein CREA7-1 4
  • Junctional Adhesion Molecule-Like 3
  • Adhesion Molecule AMICA 3
  • CREA7-1 3
  • CREA7-4 3
  • AMICA 3
  • Gm638 3

External Ids for AMICA1 Gene

Previous GeneCards Identifiers for AMICA1 Gene

  • GC00U991274
  • GC11M117570
  • GC11M118064
  • GC11M113998

Summaries for AMICA1 Gene

GeneCards Summary for AMICA1 Gene

AMICA1 (Adhesion Molecule, Interacts With CXADR Antigen 1) is a Protein Coding gene. Among its related pathways are Class I MHC mediated antigen processing and presentation and Hemostasis. GO annotations related to this gene include cell adhesion molecule binding.

UniProtKB/Swiss-Prot for AMICA1 Gene

  • Transmembrane protein of the plasma membrane of leukocytes that control their migration and activation through interaction with CXADR, a plasma membrane receptor found on adjacent epithelial and endothelial cells. The interaction between both receptors mediates the activation of gamma-delta T-cells, a subpopulation of T-cells residing in epithelia and involved in tissue homeostasis and repair. Upon epithelial CXADR-binding, AMICA1 induces downstream cell signaling events in gamma-delta T-cells through PI3-kinase and MAP kinases. It results in proliferation and production of cytokines and growth factors by T-cells that in turn stimulate epithelial tissues repair. It also controls the transmigration of leukocytes within epithelial and endothelial tissues through adhesive interactions with epithelial and endothelial CXADR.

Gene Wiki entry for AMICA1 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for AMICA1 Gene

Genomics for AMICA1 Gene

Regulatory Elements for AMICA1 Gene

Genomic Location for AMICA1 Gene

Start:
118,193,727 bp from pter
End:
118,225,094 bp from pter
Size:
31,368 bases
Orientation:
Minus strand

Genomic View for AMICA1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for AMICA1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for AMICA1 Gene

Proteins for AMICA1 Gene

  • Protein details for AMICA1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q86YT9-JAML1_HUMAN
    Recommended name:
    Junctional adhesion molecule-like
    Protein Accession:
    Q86YT9
    Secondary Accessions:
    • B0YIV1
    • B0YIV2
    • Q496M1
    • Q5DTC6
    • Q7Z499
    • Q8N9I7
    • Q8NF70

    Protein attributes for AMICA1 Gene

    Size:
    394 amino acids
    Molecular mass:
    44339 Da
    Quaternary structure:
    • Homodimer; active form in leukocyte-endothelial cell adhesion. Interacts (homodimeric form) with CXADR. Interacts (via cytoplasmic domain) with the PI3 kinase; upon CXADR-binding. Interacts with ITGA4 and ITGB1; integrin alpha-4/beta-1 may regulate leukocyte to endothelial cells adhesion by controlling AMICA1 homodimerization.
    SequenceCaution:
    • Sequence=BAC03390.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for AMICA1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for AMICA1 Gene

Proteomics data for AMICA1 Gene at MOPED

Post-translational modifications for AMICA1 Gene

  • Glycosylation at Asn76 and Asn231
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for AMICA1 Gene

Domains for AMICA1 Gene

Gene Families for AMICA1 Gene

HGNC:
  • VSET :Immunoglobulin superfamily / V-set domain containing

Protein Domains for AMICA1 Gene

Graphical View of Domain Structure for InterPro Entry

Q86YT9

UniProtKB/Swiss-Prot:

JAML1_HUMAN :
  • Q86YT9
Domain:
  • The Ig-like V-type domain 1 mediates interaction with CXADR (By similarity). The Ig-like V-type domain 2 may also play a role in the interaction (PubMed:15800062).
  • Contains 2 Ig-like V-type (immunoglobulin-like) domains.
Family:
  • Belongs to the immunoglobulin superfamily.
genes like me logo Genes that share domains with AMICA1: view

Function for AMICA1 Gene

Molecular function for AMICA1 Gene

UniProtKB/Swiss-Prot Function: Transmembrane protein of the plasma membrane of leukocytes that control their migration and activation through interaction with CXADR, a plasma membrane receptor found on adjacent epithelial and endothelial cells. The interaction between both receptors mediates the activation of gamma-delta T-cells, a subpopulation of T-cells residing in epithelia and involved in tissue homeostasis and repair. Upon epithelial CXADR-binding, AMICA1 induces downstream cell signaling events in gamma-delta T-cells through PI3-kinase and MAP kinases. It results in proliferation and production of cytokines and growth factors by T-cells that in turn stimulate epithelial tissues repair. It also controls the transmigration of leukocytes within epithelial and endothelial tissues through adhesive interactions with epithelial and endothelial CXADR.
UniProtKB/Swiss-Prot Induction: Up-regulated upon retinoic acid, Me2SO and PMA treatment in differentiating myeloid leukemia cells.

Gene Ontology (GO) - Molecular Function for AMICA1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005178 integrin binding IPI 12869515
GO:0005515 protein binding --
GO:0042803 protein homodimerization activity IDA 12869515
GO:0050839 cell adhesion molecule binding IPI 12869515
genes like me logo Genes that share ontologies with AMICA1: view
genes like me logo Genes that share phenotypes with AMICA1: view

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for AMICA1 Gene

Localization for AMICA1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for AMICA1 Gene

Cell membrane; Single-pass type I membrane protein. Cell junction. Note=Localized at the plasma membrane and enriched in areas of cell-cell contacts.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for AMICA1 Gene COMPARTMENTS Subcellular localization image for AMICA1 gene
Compartment Confidence
plasma membrane 5
endoplasmic reticulum 1
extracellular 1
golgi apparatus 1
mitochondrion 1
nucleus 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for AMICA1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005923 bicellular tight junction IDA 15800062
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with AMICA1: view

Pathways for AMICA1 Gene

genes like me logo Genes that share pathways with AMICA1: view

Interacting Proteins for AMICA1 Gene

STRING Interaction Network Preview (showing 3 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000348635%0d%0a9606.ENSP00000303351%0d%0a9606.ENSP00000380227%0d%0a9606.ENSP00000284878%0d%0a
Selected Interacting proteins: ENSP00000348635 for AMICA1 Gene via STRING

Gene Ontology (GO) - Biological Process for AMICA1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007157 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules IMP 18948633
GO:0007596 blood coagulation TAS --
GO:0030593 neutrophil chemotaxis IMP 15800062
GO:0035696 monocyte extravasation IMP 18948633
GO:0046629 gamma-delta T cell activation ISS --
genes like me logo Genes that share ontologies with AMICA1: view

Transcripts for AMICA1 Gene

Unigene Clusters for AMICA1 Gene

Adhesion molecule, interacts with CXADR antigen 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for AMICA1 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6a · 6b ^ 7 ^ 8a · 8b · 8c ^ 9a · 9b · 9c · 9d ^ 10 ^ 11a · 11b · 11c · 11d ^ 12 ^
SP1: - - - - - - - - -
SP2: - - - - -
SP3: - - - - - -
SP4: - - - - -
SP5: - - - - - - -
SP6: - - -
SP7: - - - - - -
SP8: - - - - - - -
SP9: - - - -
SP10:
SP11: -
SP12:

ExUns: 13a · 13b · 13c
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:

Relevant External Links for AMICA1 Gene

GeneLoc Exon Structure for
AMICA1
ECgene alternative splicing isoforms for
AMICA1

Expression for AMICA1 Gene

mRNA expression in normal human tissues for AMICA1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for AMICA1 Gene

This gene is overexpressed in Whole Blood (40.1).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for AMICA1 Gene

SOURCE GeneReport for Unigene cluster for AMICA1 Gene Hs.16291

mRNA Expression by UniProt/SwissProt for AMICA1 Gene

Q86YT9-JAML1_HUMAN
Tissue specificity: Expression is restricted to the hematopoietic tissues with the exception of liver. Expressed in fetal liver, spleen and thymus. Preferentially expressed by mature leukocytes (at protein level).
genes like me logo Genes that share expressions with AMICA1: view

Orthologs for AMICA1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for AMICA1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia AMICA1 35
  • 99.49 (n)
  • 98.98 (a)
AMICA1 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia AMICA1 35
  • 79.63 (n)
  • 69.19 (a)
AMICA1 36
  • 69 (a)
OneToOne
dog
(Canis familiaris)
Mammalia AMICA1 35
  • 82.11 (n)
  • 73.09 (a)
AMICA1 36
  • 69 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Amica1 35
  • 69.91 (n)
  • 60.74 (a)
Amica1 16
Amica1 36
  • 57 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Amica1 35
  • 72.04 (n)
  • 64.52 (a)
chicken
(Gallus gallus)
Aves AMICA1 36
  • 26 (a)
OneToOne
Species with no ortholog for AMICA1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for AMICA1 Gene

ENSEMBL:
Gene Tree for AMICA1 (if available)
TreeFam:
Gene Tree for AMICA1 (if available)

Paralogs for AMICA1 Gene

Selected SIMAP similar genes for AMICA1 Gene using alignment to 10 proteins:

genes like me logo Genes that share paralogs with AMICA1: view

No data available for Paralogs for AMICA1 Gene

Variants for AMICA1 Gene

Sequence variations from dbSNP and Humsavar for AMICA1 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs1805 -- 118,205,354(-) CGGGA(A/C)CTCTA intron-variant
rs1806 -- 118,205,289(+) ATATA(C/T)GACCA intron-variant
rs590580 -- 118,195,389(+) CTGGT(A/G)CGATA intron-variant
rs605560 -- 118,196,472(+) GTCCT(C/G)CCTGC intron-variant
rs605908 -- 118,196,477(+) CCCTG(A/C)CCTCA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for AMICA1 Gene

Variant ID Type Subtype PubMed ID
nsv511 CNV Insertion 18451855

Relevant External Links for AMICA1 Gene

HapMap Linkage Disequilibrium report
AMICA1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for AMICA1 Gene

Disorders for AMICA1 Gene

Relevant External Links for AMICA1

Genetic Association Database (GAD)
AMICA1
Human Genome Epidemiology (HuGE) Navigator
AMICA1
genes like me logo Genes that share disorders with AMICA1: view

No data available for UniProtKB/Swiss-Prot for AMICA1 Gene

Publications for AMICA1 Gene

  1. JAML, a novel protein with characteristics of a junctional adhesion molecule, is induced during differentiation of myeloid leukemia cells. (PMID: 12869515) Moog-Lutz C. … Lutz P.G. (Blood 2003) 3 4 23
  2. Neutrophil migration across tight junctions is mediated by adhesive interactions between epithelial CAR and a JAM-like protein on neutrophils. (PMID: 15800062) Zen K. … Parkos C.A. (Mol. Biol. Cell 2005) 3 4 23
  3. Role of junctional adhesion molecule-like protein in mediating monocyte transendothelial migration. (PMID: 18948633) Guo Y.L. … Zen K. (Arterioscler. Thromb. Vasc. Biol. 2009) 3 4 23
  4. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 2 3 4
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4

Products for AMICA1 Gene

Sources for AMICA1 Gene

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