Aliases for AMICA1 Gene
External Ids for AMICA1 Gene
Previous GeneCards Identifiers for AMICA1 Gene
GeneCards Summary for AMICA1 Gene
AMICA1 (Adhesion Molecule, Interacts With CXADR Antigen 1) is a Protein Coding gene. Among its related pathways are Immune System and Hemostasis. GO annotations related to this gene include protein homodimerization activity and cell adhesion molecule binding.
UniProtKB/Swiss-Prot for AMICA1 Gene
Transmembrane protein of the plasma membrane of leukocytes that control their migration and activation through interaction with CXADR, a plasma membrane receptor found on adjacent epithelial and endothelial cells. The interaction between both receptors mediates the activation of gamma-delta T-cells, a subpopulation of T-cells residing in epithelia and involved in tissue homeostasis and repair. Upon epithelial CXADR-binding, AMICA1 induces downstream cell signaling events in gamma-delta T-cells through PI3-kinase and MAP kinases. It results in proliferation and production of cytokines and growth factors by T-cells that in turn stimulate epithelial tissues repair. It also controls the transmigration of leukocytes within epithelial and endothelial tissues through adhesive interactions with epithelial and endothelial CXADR.