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AMICA1 Gene

protein-coding   GIFtS: 56
GCID: GC11M118064

Adhesion Molecule, Interacts With CXADR Antigen 1

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Adhesion Molecule, Interacts With CXADR Antigen 11 2     Gm6382
JAML2 3 5     Adhesion Molecule AMICA2
Adhesion Molecule Interacting With CXADR Antigen 12 3     Dendritic-Cell Specific Protein CREA7-12
AMICA2     Dendritic-Cell Specific Protein CREA7-42
CREA7-12     Junctional Adhesion Molecule-Like2
CREA7-42     Dendritic Cell-Specific Protein CREA7-13

External Ids:    HGNC: 190841   Entrez Gene: 1204252   Ensembl: ENSG000001605937   OMIM: 6097705   UniProtKB: Q86YT93   

Export aliases for AMICA1 gene to outside databases

Previous GC identifers: GC00U991274 GC11M117570 GC11M113998


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for AMICA1 Gene:
AMICA1 (adhesion molecule, interacts with CXADR antigen 1) is a protein-coding gene. Diseases associated with AMICA1 include endotheliitis, and myeloid leukemia. GO annotations related to this gene include cell adhesion molecule binding.

UniProtKB/Swiss-Prot: JAML1_HUMAN, Q86YT9
Function: Transmembrane protein of the plasma membrane of leukocytes that control their migration and activation
through interaction with CXADR, a plasma membrane receptor found on adjacent epithelial and endothelial cells.
The interaction between both receptors mediates the activation of gamma-delta T cells, a subpopulation of T cells
residing in epithelia and involved in tissue homeostasis and repair. Upon epithelial CXADR-binding, AMICA1
induces downstream cell signaling events in gamma-delta T cells through PI3-kinase and MAP kinases. It results in
proliferation and production of cytokines and growth factors by T cells that in turn stimulate epithelial tissues
repair. It also controls the transmigration of leukocytes within epithelial and endothelial tissues through
adhesive interactions with epithelial and endothelial CXADR

Gene Wiki entry for AMICA1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000011.10  NT_033899.9  NC_018922.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the AMICA1 gene promoter:
         AML1a   FOXO4   ARP-1   Msx-1   Cdc5   C/EBPalpha   Hlf   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidAMICA1 promoter sequence
   Search Chromatin IP Primers for AMICA1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat AMICA1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q23.3   Ensembl cytogenetic band:  11q23.3   HGNC cytogenetic band: 11q23.3

AMICA1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
AMICA1 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11M118064:  view genomic region     (about GC identifiers)

Start:
118,064,442 bp from pter      End:
118,095,809 bp from pter
Size:
31,368 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: JAML1_HUMAN, Q86YT9 (See protein sequence)
Recommended Name: Junctional adhesion molecule-like precursor  
Size: 394 amino acids; 44339 Da
Subunit: Homodimer; active form in leukocyte-endothelial cell adhesion. Interacts (homodimeric form) with CXADR.
Interacts (via cytoplasmic domain) with the PI3 kinase; upon CXADR-binding. Interacts with ITGA4 and ITGB1;
integrin alpha-4/beta-1 may regulate leukocyte to endothelial cells adhesion by controlling AMICA1
homodimerization
Sequence caution: Sequence=BAC03390.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;
Secondary accessions: B0YIV1 B0YIV2 Q5DTC6 Q7Z499 Q8N9I7 Q8NF70
Alternative splicing: 3 isoforms:  Q86YT9-1   Q86YT9-2   Q86YT9-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for AMICA1: NX_Q86YT9

Explore proteomics data for AMICA1 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn76, Asn231
  • Modification sites at PhosphoSitePlus

  • See AMICA1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (4 alternative transcripts): 
    NP_001091996.1  NP_001273499.1  NP_001273500.1  NP_694938.2  

    ENSEMBL proteins: 
     ENSP00000348635   ENSP00000292067   ENSP00000436117   ENSP00000431614   ENSP00000431218  
     ENSP00000432769   ENSP00000435145   ENSP00000431791  
    Reactome Protein details: Q86YT9

    AMICA1 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
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    Novus Biologicals AMICA1 Protein
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    Sino Biological Recombinant Protein for AMICA1
    Sino Biological Cell Lysate for AMICA1
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    Cloud-Clone Corp. Proteins for AMICA1

    AMICA1 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    R&D Systems Antibodies for AMICA1 (AMICA/JAML)
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    Abcam antibodies for AMICA1
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    LSBio Antibodies in human, mouse, rat for AMICA1

    AMICA1 Assay Products:

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    Cloud-Clone Corp. ELISAs for AMICA1
    Cloud-Clone Corp. CLIAs for AMICA1


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    VSET: Immunoglobulin superfamily / V-set domain containing

    4 InterPro protein domains:
     IPR013783 Ig-like_fold
     IPR013106 Ig_V-set
     IPR007110 Ig-like_dom
     IPR003599 Ig_sub

    Graphical View of Domain Structure for InterPro Entry Q86YT9

    ProtoNet protein and cluster: Q86YT9

    1 Blocks protein domain: IPB013106 Immunoglobulin V-set

    UniProtKB/Swiss-Prot: JAML1_HUMAN, Q86YT9
    Domain: The Ig-like V-type domain 1 mediates interaction with CXADR (By similarity). The Ig-like V-type domain 2
    may also play a role in the interaction (PubMed:15800062)
    Similarity: Belongs to the immunoglobulin superfamily
    Similarity: Contains 2 Ig-like V-type (immunoglobulin-like) domains


    AMICA1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: JAML1_HUMAN, Q86YT9
    Function: Transmembrane protein of the plasma membrane of leukocytes that control their migration and activation
    through interaction with CXADR, a plasma membrane receptor found on adjacent epithelial and endothelial cells.
    The interaction between both receptors mediates the activation of gamma-delta T cells, a subpopulation of T cells
    residing in epithelia and involved in tissue homeostasis and repair. Upon epithelial CXADR-binding, AMICA1
    induces downstream cell signaling events in gamma-delta T cells through PI3-kinase and MAP kinases. It results in
    proliferation and production of cytokines and growth factors by T cells that in turn stimulate epithelial tissues
    repair. It also controls the transmigration of leukocytes within epithelial and endothelial tissues through
    adhesive interactions with epithelial and endothelial CXADR
    Induction: Up-regulated upon retinoic acid, Me2SO and PMA treatment in differentiating myeloid leukemia cells

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005178integrin binding IPI12869515
    GO:0005515protein binding ----
    GO:0042803protein homodimerization activity IDA12869515
    GO:0050839cell adhesion molecule binding IPI12869515
         
    AMICA1 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for AMICA1:
     Decreased viability of wild-ty  Increased HPV18 LCR reporter a 

         1 MGI phenotypic allele for Amica1 (no phenotypes)

    AMICA1 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Amica1tm1Lex for AMICA1

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for AMICA1
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for AMICA1
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for AMICA1

    miRNA
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    Block miRNA regulation of human, mouse, rat AMICA1 using miScript Target Protectors
    1 qRT-PCR Assays for microRNA that regulate AMICA1:
    hsa-miR-3692
    SwitchGear 3'UTR luciferase reporter plasmidAMICA1 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for AMICA1
    Predesigned siRNA for gene silencing in human, mouse, rat AMICA1

    Gene Editing
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    GenScript: all cDNA clones in your preferred vector (see all 2): AMICA1 (NM_001098526)
    Sino Biological Human cDNA Clone for AMICA1
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for AMICA1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat AMICA1

    Cell Line
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for AMICA1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    JAML1_HUMAN, Q86YT9: Cell membrane; Single-pass type I membrane protein. Cell junction. Note=Localized at the
    plasma membrane and enriched in areas of cell-cell contacts
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5
    endoplasmic reticulum1
    extracellular1
    golgi apparatus1
    mitochondrion1
    nucleus1
    peroxisome1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0005923tight junction IDA15800062
    GO:0016021integral component of membrane IEA--

    AMICA1 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for AMICA1 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Hemostasis
    Hemostasis0.43
    2Class I MHC mediated antigen processing and presentation
    Adaptive Immune System0.41
    3Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
    Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
    4Cell surface interactions at the vascular wall
    Cell surface interactions at the vascular wall

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    2 Reactome Pathways for AMICA1
        Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
    Cell surface interactions at the vascular wall



    AMICA1 for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for AMICA1
    Interactions:

        GeneGlobe Interaction Network for AMICA1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 12)

    Selected Interacting proteins for AMICA1 (ENSP000003486354) via UniProtKB, MINT, STRING, and/or I2D (see all 12)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ITGA4ENSP000003802274STRING: ENSP00000380227
    ITGAXENSP000002682964STRING: ENSP00000268296
    ITGB2ENSP000003032424STRING: ENSP00000303242
    ITGB1ENSP000003640944STRING: ENSP00000364094
    TAPBPLENSP000002665564STRING: ENSP00000266556
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007157heterophilic cell-cell adhesion IMP18948633
    GO:0007596blood coagulation TAS--
    GO:0030593neutrophil chemotaxis IMP15800062
    GO:0035696monocyte extravasation IMP18948633
    GO:0046629gamma-delta T cell activation ISS--

    AMICA1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for AMICA1 (JAML1)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for AMICA1 gene (4 alternative transcripts): 
    NM_001098526.1  NM_001286570.1  NM_001286571.1  NM_153206.2  

    Unigene Cluster for AMICA1:

    Adhesion molecule, interacts with CXADR antigen 1
    Hs.16291  [show with all ESTs]
    Unigene Representative Sequence: AK090409
    12 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000356289(uc001psh.2 uc009yzw.1 uc001psk.2 uc010rxw.1)
    ENST00000292067(uc001psi.2) ENST00000534294(uc010rxx.1) ENST00000533261
    ENST00000526595(uc001psl.1) ENST00000531530(uc001psg.2) ENST00000526620
    ENST00000529164 ENST00000531536 ENST00000524477 ENST00000527877 ENST00000525565

    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat AMICA1 using miScript Target Protectors
    1 qRT-PCR Assays for microRNA that regulate AMICA1:
    hsa-miR-3692
    SwitchGear 3'UTR luciferase reporter plasmidAMICA1 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for AMICA1
    Predesigned siRNA for gene silencing in human, mouse, rat AMICA1
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    GenScript: all cDNA clones in your preferred vector (see all 2): AMICA1 (NM_001098526)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for AMICA1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat AMICA1
    Primer
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    OriGene qSTAR qPCR primer pairs in human, mouse for AMICA1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat AMICA1
      QuantiTect SYBR Green Assays in human, mouse, rat AMICA1
      QuantiFast Probe-based Assays in human, mouse, rat AMICA1

    Additional mRNA sequence: 

    AJ515553.2 AK057581.1 AK057590.1 AK090409.1 AK094399.1 AK097285.1 AK298722.1 AK300851.1 
    AK301099.1 AY093686.1 AY093687.1 AY138965.1 AY358362.1 BC100794.2 BC100795.2 BC100796.1 
    BC100797.1 

    12 DOTS entries:

    DT.101982016  DT.99998898  DT.95263479  DT.99936254  DT.109017  DT.101961445  DT.95166066  DT.95166068 
    DT.120705906  DT.120705907  DT.100702098  DT.100738912 

    Selected AceView cDNA sequences (see all 89):

    CR596683 AI871971 BM983629 CR611880 AI800408 CR598736 AW501105 CF121828 
    AI354980 CD366178 BQ184892 CA444312 BF002780 AI088612 AK090409 AL546758 
    C01482 AY138965 AV647457 AI291283 CF541186 CA306656 CB528873 AW500962 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for AMICA1 (see all 12)    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6a · 6b ^ 7 ^ 8a · 8b · 8c ^ 9a · 9b · 9c · 9d ^ 10 ^ 11a · 11b · 11c · 11d ^ 12 ^
    SP1:                          -           -     -     -     -                                         -                             -           -     -         
    SP2:                                                        -                                         -                             -           -     -         
    SP3:                                                  -     -                                         -                             -           -     -         
    SP4:                                                  -     -                                         -                             -                 -         
    SP5:                          -           -     -     -     -                                         -                             -                           

    ExUns: 13a · 13b · 13c
    SP1:                  
    SP2:                  
    SP3:                  
    SP4:                  
    SP5:                  


    ECgene alternative splicing isoforms for AMICA1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    AMICA1 expression in normal human tissues (normalized intensities)      AMICA1 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GACTTGGCCT
    AMICA1 Expression
    About this image


    AMICA1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 2) fully expand
     
     Blood (Hematopoietic System)
             Granulocytes Peripheral Blood
     
     Spleen (Hematopoietic System)
    AMICA1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    AMICA1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.16291

    UniProtKB/Swiss-Prot: JAML1_HUMAN, Q86YT9
    Tissue specificity: Expression is restricted to the hematopoietic tissues with the exception of liver. Expressed
    in fetal liver, spleen and thymus. Preferentially expressed by mature leukocytes (at protein level)

        Custom PCR Arrays for AMICA1
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    QuantiFast Probe-based Assays in human, mouse, rat AMICA1
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for AMICA1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for AMICA1 gene from Selected species (see all 6)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Amica11 , 5 adhesion molecule, interacts with CXADR antigen 11, 5 69.91(n)1
    60.74(a)1
      9 (24.84 cM)5
    2701521  NM_001005421.41  NP_001005421.31 
     450791835 
    chicken
    (Gallus gallus)
    Aves AMICA16
    adhesion molecule, interacts with CXADR antigen 1
    26(a)
    1 ↔ 1
    24(5452747-5454564) ENSGALG00000024072


    ENSEMBL Gene Tree for AMICA1 (if available)
    TreeFam Gene Tree for AMICA1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for AMICA1 gene
    1 SIMAP similar gene for AMICA1 using alignment to 10 protein entries:     JAML1_HUMAN (see all proteins):
    CREA7-4

    AMICA1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for AMICA1 (see all 681)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1877036241,2
    --118064023(+) GATTCC/TCAGCT 2 -- ds50010--------
    rs455551321,2
    C,F--118064030(+) AGCTTG/TGTTGC 2 -- ds50013Minor allele frequency- T:0.03NS NA EA 280
    rs1910726161,2
    --118064098(+) TGCTGA/GATTCA 2 -- ds50010--------
    rs1505151511,2
    --118064245(+) CCTTAC/TCAAAT 2 -- ds50010--------
    rs1403262091,2
    --118064369(+) ACCCAA/GAAATT 2 -- ds50010--------
    rs1442897111,2
    --118064400(+) TGAGGA/CCCCGC 2 -- ds50010--------
    rs37413161,2
    C,F,H--118064530(+) TAGCAC/TGGTTT 2 -- ut317Minor allele frequency- T:0.03EA NS 2398
    rs1131757241,2
    C,F--118064531(+) AGCACG/AGTTTG 2 -- ut312Minor allele frequency- A:0.04WA 120
    rs6192501,2
    C,F,O,A,H--118064582(+) CTGTAA/C/TATTCC 4 -- ut3138NA MN NS EA WA CSA 3479
    rs775887191,2
    C,F--118064632(+) AATAGG/CACGAT 2 -- ut311Minor allele frequency- C:0.02WA 118

    HapMap Linkage Disequilibrium report for AMICA1 (118064442 - 118095809 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for AMICA1:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv511CNV Insertion18451855

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing AMICA1
    DNA2.0 Custom Variant and Variant Library Synthesis for AMICA1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 609770    OMIM disorders: --

    3 diseases for AMICA1:    About MalaCards
    endotheliitis    myeloid leukemia    leukemia


    AMICA1 for disorders           About GeneDecksing

    Genetic Association Database (GAD): AMICA1
    Human Genome Epidemiology (HuGE) Navigator: AMICA1 (1 document)

    Export disorders for AMICA1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for AMICA1 gene, integrated from 10 sources (see all 12):
    (articles sorted by number of sources associating them with AMICA1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2, 3 Clark H.F.... Gray A.M. (Genome Res. 2003)
    2. Role of junctional adhesion molecule-like protein in mediating monocyte transendothelial migration. (PubMed id 18948633)1, 2, 9 Guo Y.L....Zen K. (Arterioscler. Thromb. Vasc. Biol. 2009)
    3. JAML, a novel protein with characteristics of a junctional adhesion molecule, is induced during differentiation of myeloid leukemia cells. (PubMed id 12869515)1, 2, 9 Moog-Lutz C.... Lutz P.G. (Blood 2003)
    4. Neutrophil migration across tight junctions is mediated by adhesive interactions between epithelial CAR and a JAM-like protein on neutrophils. (PubMed id 15800062)1, 2, 9 Zen K....Parkos C.A. (Mol. Biol. Cell 2005)
    5. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    6. JAM-L-mediated leukocyte adhesion to endothelial cells is regulated in cis by alpha4beta1 integrin activation. (PubMed id 19064666)1, 2 Luissint A.C....Bourdoulous S. (J. Cell Biol. 2008)
    7. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    8. Signal peptide prediction based on analysis of experimentally verified cleavage sites. (PubMed id 15340161)1, 2 Zhang Z. and Henzel W.J. (Protein Sci. 2004)
    9. A secreted protein microarray platform for extracellular protein interaction discovery. (PubMed id 21982860)1 Ramani S.R....Gonzalez L.C. (Anal. Biochem. 2012)
    10. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (Genome Res. 2006)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 120425 HGNC: 19084 AceView: AMICA Ensembl:ENSG00000160593 euGenes: HUgn120425
    ECgene: AMICA1 H-InvDB: AMICA1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for AMICA1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for AMICA1 gene:
    Search GeneIP for patents involving AMICA1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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