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Aliases & Descriptions for AMH
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase) About This Section
|
| | | Descriptions |
|---|
| Anti-Muellerian hormone 3 | | Muellerian-inhibiting substance 3 | | Mullerian inhibiting factor 2 | | Mullerian inhibiting substance 2 | | anti-Mullerian hormone 2 |
|
| | Search outside databases for aliases for AMH genePrevious GC identifers: GC19P002311 GC19P002188 |
Summaries for AMH(According to Entrez Gene,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| EntrezGene summary for AMH: Anti-Mullerian hormone is a member of the transforming growth factor-beta gene family which mediates male sexual differentiation. Anti-Mullerian hormone causes the regression of Mullerian ducts which would otherwise differentiate into the uterus and fallopian tubes. Some mutations in the anti-Mullerian hormone result in persistent Mullerian duct syndrome. [provided by RefSeq] UniProtKB/Swiss-Prot: MIS_HUMAN, P03971Function: This glycoprotein, produced by the Sertoli cells of the testis, causes regression of the Muellerian duct. It is also able to inhibit the growth of tumors derived from tissues of Muellerian duct origin |
Genomic Location for AMH
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to
UCSC and
Ensembl,
Transcription factor binding sites according to
SABiosciences) About This Section
| Genomic View: UCSC Golden Path with GeneCards custom track
Transcription factor binding sites upstream to the AMH gene 
Entrez Gene cytogenetic band: 19p13.3 Ensembl cytogenetic band: 19p13.3 HGNC cytogenetic band: 19p13.3AMH Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)
 GeneLoc gene densities for chromosome 19 GeneLoc Exon Structure GeneLoc location for GC19P002200:
(about GC identifiers)
Start:
|
2,200,113 bp from pter |
End:
|
2,203,072 bp from pter |
Size:
|
2,960 bases |
Orientation:
|
plus strand |
RefSeq DNA sequence:- NC_000019.8 NT_011255.14
| Proteins for AMH
(According to
1UniProtKB,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Enzo Life Sciences,
Abnova,
OriGene and/or,
Abcam,
Biochemical Assays by
Invitrogen,
Millipore,
R&D Systems,
Cell Signaling Technology, and/or
Enzo Life Sciences,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene,
Antibodies by Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Cell Signaling Technology,
Abcam,
Abnova, and/or
Novus Biologicals)
About This Section
| UniProtKB/Swiss-Prot: MIS_HUMAN, P03971 (See
protein sequence)Recommended Name: Muellerian-inhibiting factor precursor Size: 560 amino acids; 59221 Da
Subunit: Homodimer; disulfide-linked
Subcellular location: Secreted
Miscellaneous: Although it does not compete with EGF for receptor binding sites, MIS can inhibit the autophosphorylation of the EGF receptor in vitro
Secondary accessions: O75246REFSEQ proteins: NP_000470.2
ENSEMBL proteins: ENSP00000221496
Human Recombinant Proteins Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 
3 Gene Ontology (GO) cellular component terms (links to tree view): About this table
Antibodies for AMH: Assays for AMH: | Protein
Domains/ Families for AMH(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| - Graphical View of Domain Structure for InterPro Entry P03971
ProtoNet protein and cluster: P03971 3 Blocks protein families: IPB001839 Transforming growth factor beta (TGFb) IPB002400 Growth factor cystine knot superfamily signature IPB006799 Anti-Mullerian hormone
UniProtKB/Swiss-Prot: MIS_HUMAN, P03971Similarity: Belongs to the TGF-beta family | Gene Function for AMH
(According to MGI Jun 06 2009, UniProtKB,
IUBMB,and/or Genatlas,
shRNA from
OriGene,
Sigma-Aldrich, RNAi from
Sigma-Aldrich,
RNAi Products,
Clones, and
Q-PCR Products
from Invitrogen,
Millipore,
OriGene, and/or
Abnova,
siRNAs from
Applied Biosystems,
SYBR primers from OriGene,
Cell-based Assays from Millipore,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_000479
Applied Biosystems Silencer® siRNAs for AMH
Sigma-Aldrich siRNA and siRNA Panels for AMH  Sigma-Aldrich shRNA for AMH  Explore Sigma-Aldrich super-pooled esiRNAs 
              OriGene GFP tagged cDNA clone in CMV expression vector: NM_000479                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_000479                                  untagged cDNA clone in CMV expression vector: NM_000479 
Primers: Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers               OriGene genome-wide validated SYBR primer pairs: NM_000479
UniProtKB/Swiss-Prot: MIS_HUMAN, P03971Function: This glycoprotein, produced by the Sertoli cells of the testis, causes regression of the Muellerian duct. It is also able to inhibit the growth of tumors derived from tissues of Muellerian duct originGenatlas biochemistry entry for AMH:anti-Mullerian hormone (TGFB superfamily),140kDa,expressed in the Sertoli cells of the fetal and neonatal testis,preventing the development of the uterus and fallopian tubes in male5 MGI mutant phenotypes (inferred from 9 alleles ) (MGI details for Amh):
3 Gene Ontology (GO) molecular function terms (links to tree view): About this table | Pathways & Interactions for AMH
(Pathways according to Invitrogen
(maps by GeneGo),
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Proteins Network according to
SABiosciences,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
| 1 Sigma-Aldrich "Your Favorite Gene" Pathway for AMH (Your Favorite Gene powered by Ingenuity) 
Gene Network CentralTM Interacting Genes and Proteins Network for AMH 
5/47 Interacting proteins for AMH (ENSP000002214963) via UniProtKB, MINT, and/or STRING (see all 47
)About this table
5/6 Gene Ontology (GO) biological process terms (links to tree view) (see all 6
): About this table
|
Drugs & Compounds for AMH(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
Browse Tocris compounds for AMH 3 Novoseek chemical compound relationships for AMH gene
About this table
|
Transcripts for AMH(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from Invitrogen,
Millipore, and/or
Abnova,
siRNAs from Applied Biosystems,
Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
Tagged/untagged cDNA clones from
OriGene, Expression Assays from Applied Biosystems) About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_000479
Sigma-Aldrich siRNA and siRNA Panels for AMH  Sigma-Aldrich shRNA for AMH  Explore Sigma-Aldrich super-pooled esiRNAs 
Applied Biosystems Silencer® siRNAs: NM_000479 REFSEQ mRNAs for AMH gene: NM_000479.3
Applied Biosystems TaqMan ® Gene Expression Assays: NM_000479               OriGene GFP tagged cDNA clone in CMV expression vector: NM_000479                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_000479                                  untagged cDNA clone in CMV expression vector: NM_000479  Additional cDNA sequence: BC033218.1 BC049194.1 5 DOTS entries: DT.40307359 DT.95266731 DT.121414485 DT.97837972 DT.403963 24/337 AceView cDNA sequences (see all 337
):BI253981 AI985837 CA394998 BI769959 BM927190 AA588895 CR618008 CA398124 BQ215965 BM454230 AI702367 BM855704 CR593881 CR600654 CR591027 BQ720593 BQ898149 BQ220299 BI909634 CA388888 BQ428045 CR619009 AW732696 BQ437394
highest scoring ESTs for AMH:AA316792 AI085509 AI589611 AI811492 AW589622 AW950143 AW950180 BC049194 BG912023 BI819038 Unigene Cluster for AMH: Anti-Mullerian hormone Hs.112432 [show with all ESTs]Unigene Representative Sequence: NM_000479
GeneLoc Exon Structure
3 Alternative Splicing Database (ASD) splice patterns (SP) for AMH
| ExUns: | 1 | ^ | 2a | · | 2b | ^ | 3a | · | 3b | ^ | 4a | · | 4b | ^ | 5 | |
| SP1: | |   | |   | |   | |   | |   | |   | |   | |   | |
| SP2: | |   | - |   | - |   | |   | |   | |   | |   | |   | |
| SP3: | |   | |   | |   | |   | |   | |   | |   | |   |
About this scheme
ECgene alternative splicing isoforms for AMH
1 Ensembl transcript including schematic representation: ENST00000221496
|
Expression for AMH
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Expression Assays from
Applied Biosystems
)
About This Section
| AMH expression in normal and diseased human tissues
Applied Biosystems TaqMan ® Gene Expression Assays for AMH
1 / 2 / 3 3 probe-sets matching AMH gene Data from
(Publications) and GNF BioGPS About these images About these images
CGAP SAGE TAG: GTGGCCACCG
SOURCE GeneReport for Unigene cluster: Hs.112432
Expression variation in blood from EXPOLDB for AMH |
Orthologs for AMH
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for AMH gene from 5/6 species (see all 6
)
About this table Species with no ortholog for AMH
ENSEMBL Gene Tree for AMH | Paralogs for AMH(Paralogs according to 1HomoloGene and 2Ensembl, Pseudogenes according to 3Pseudogene.org) About This Section
| -- |
SNPs/Variants for AMH(According to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Genotyping Reagents from
Applied Biosystems)
About This Section
|
HapMap Linkage Disequilibrium images for AMH (up to first 250kb)
|
Disorders & Mutations for AMH
(in which this Gene is Involved, According to
OMIM, UniProtKB,
Novoseek, PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
HGMD, GAD,
HuGE Navigator,
BCGD,
and/or TGDB.)
About This Section
|
OMIM: 600957 disorders: 261550 UniProtKB/Swiss-Prot: MIS_HUMAN, P03971
Defects in AMH are the cause of persistent Muellerian duct syndrome type 1 (PMDS-1) [MIM:261550]. PMDS-1 is a form of male pseudohermaphroditism characterized by a failure of Muellerian duct regression in otherwise normal males10/13 Novoseek disease relationships for AMH gene (see all 13
)
About this table
Genatlas disease: AMH persistent Mullerian duct syndrome Human Gene Mutation Database: AMH Genetic Association Database: AMH Human Genome Epidemiology Navigator: AMH (11 documents)
|
Medical News for AMH(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications for AMH (in
PubMed.
Associations of this gene to articles via
1Novoseek,
2HGNC,
3Entrez Gene,
4UniProtKB/Swiss-Prot,
5UniProtKB/TrEMBL,
6GAD, and/or
7PharmGKB)
About This Section
| 10/156 PubMed articles for AMH gene (see all 156
):- Isolation of the bovine and human genes for Mullerian inhibiting substance and expression of the human gene in animal cells. (PubMed id 3754790)2, 3, 4 Cate R.L.... Donahoe P.K. (1986)
- Anti-mullerian hormone is an endocrine marker of ovarian gonadotropin-responsive follicles and can help to predict superovulatory responses in the cow. (PubMed id 18784351)1, 2, 3 Rico C....Monniaux D. (2009)
- The DNA sequence and biology of human chromosome 19. (PubMed id 15057824)3, 4 Grimwood J.... Lucas S.M. (2004)
- Mutational analysis of the mullerian-inhibiting substance gene and its receptor gene in Japanese women with polycystic ovary syndrome and premature ovarian failure. (PubMed id 12477536)3, 6 Wang H.Q....Noda Y. (2002)
- Molecular genetics of the persistent Mullerian duct syndrome: a study of 19 families. (PubMed id 8162013)3, 4 Imbeaud S....Picard J.-Y. (1994)
- Variants of the anti-Mullerian hormone gene in a compound heterozygote with the persistent Mullerian duct syndrome and his family. (PubMed id 1483695)3, 4 Carre-Eusebe D....Picard J.-Y. (1992)
- DNA sequence variations of the entire anti-Mullerian hormone (AMH) gene promoter and AMH protein expression in patients with the Mayer-Rokitanski-Kuster-Hauser syndrome. (PubMed id 15550498)1, 3 Oppelt P....Strick R. (2005)
- Anti-Mullerian hormone expression pattern in the human ovary: potential implications for initial and cyclic follicle recruitment. (PubMed id 14742691)1, 3 Weenen C....Themmen A.P. (2004)
- Evaluation of different markers of the ovarian reserve in patients presenting with premature ovarian failure. (PubMed id 18191888)1, 3 Massin N....Touraine P. (2008)
- Anti-mullerian hormone protein expression is reduced during the initial stages of follicle development in human polycystic ovaries. (PubMed id 16030171)1, 3 Stubbs S.A....Franks S. (2005)
|
Search for AMH
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
|
|
Genome Databases showing AMH
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
and/or
H-InvDB)
About This Section
|
| Other Databases showing AMH
(According to HUGE)
About This Section
| -- |
Specialized Databases showing AMH(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
|
| About This Section
| --
| Services for AMH(Reagents available from Applied Biosystems, Antibodies and assays by Cell
Signaling Technology, Abcam, Novus Biologicals, Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich, Enzo Life Sciences, and/or Tocris Bioscience) About This Section
| 
 Products for AMH:

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