Aliases for AMFR Gene
External Ids for AMFR Gene
This locus encodes a glycosylated transmembrane receptor. Its ligand, autocrine motility factor, is a tumor motility-stimulating protein secreted by tumor cells. The encoded receptor is also a member of the E3 ubiquitin ligase family of proteins. It catalyzes ubiquitination and endoplasmic reticulum-associated degradation of specific proteins. [provided by RefSeq, Feb 2012]
GeneCards Summary for AMFR Gene
AMFR (Autocrine Motility Factor Receptor, E3 Ubiquitin Protein Ligase) is a Protein Coding gene. Diseases associated with AMFR include colorectal cancer. Among its related pathways are Regulation of Cholesterol Biosynthesis by SREBP (SREBF) and Protein Stability. GO annotations related to this gene include ubiquitin-protein transferase activity and receptor activity. An important paralog of this gene is RNF145.
UniProtKB/Swiss-Prot for AMFR Gene
E3 ubiquitin-protein ligase that mediates the polyubiquitination of a number of proteins such as CD3D, CYP3A4, CFTR and APOB for proteasomal degradation. Component of a VCP/p97-AMFR/gp78 complex that participates in the final step of endoplasmic reticulum-associated degradation (ERAD). The VCP/p97-AMFR/gp78 complex is involved in the sterol-accelerated ERAD degradation of HMGCR through binding to the HMGCR-INSIG complex at the ER membrane and initiating ubiquitination of HMGCR. The ubiquitinated HMGCR is then released from the ER by the complex into the cytosol for subsequent destruction. Also acts as a scaffold protein to assemble a complex that couples ubiquitination, retranslocation and deglycosylation. Mediates tumor invasion and metastasis as a receptor for the GPI/autocrine motility factor.