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Aliases for AMER3 Gene

Aliases for AMER3 Gene

  • APC Membrane Recruitment Protein 3 2 3
  • Family With Sequence Similarity 123C 2 3
  • Protein FAM123C 3 4
  • FAM123C 3 4
  • Amer3 4

External Ids for AMER3 Gene

Previous HGNC Symbols for AMER3 Gene

  • FAM123C

Previous GeneCards Identifiers for AMER3 Gene

  • GC02P131514
  • GC02P131538

Summaries for AMER3 Gene

GeneCards Summary for AMER3 Gene

AMER3 (APC Membrane Recruitment Protein 3) is a Protein Coding gene. GO annotations related to this gene include lipid binding. An important paralog of this gene is AMER2.

UniProtKB/Swiss-Prot for AMER3 Gene

  • Regulator of the canonical Wnt signaling pathway. Acts by specifically binding phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2), translocating to the cell membrane (By similarity).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for AMER3 Gene

Genomics for AMER3 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for AMER3 Gene

130,755,435 bp from pter
130,768,134 bp from pter
12,700 bases
Plus strand

Genomic View for AMER3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for AMER3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for AMER3 Gene

No data available for Regulatory Elements for AMER3 Gene

Proteins for AMER3 Gene

  • Protein details for AMER3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    APC membrane recruitment protein 3
    Protein Accession:
    Secondary Accessions:
    • B7ZLH6

    Protein attributes for AMER3 Gene

    861 amino acids
    Molecular mass:
    90445 Da
    Quaternary structure:
    No Data Available

neXtProt entry for AMER3 Gene

Proteomics data for AMER3 Gene at MOPED

Post-translational modifications for AMER3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for AMER3 Gene

No data available for DME Specific Peptides for AMER3 Gene

Domains for AMER3 Gene

Protein Domains for AMER3 Gene


Graphical View of Domain Structure for InterPro Entry



  • Q8N944
  • Belongs to the Amer family.
genes like me logo Genes that share domains with AMER3: view

No data available for Gene Families and Suggested Antigen Peptide Sequences for AMER3 Gene

Function for AMER3 Gene

Molecular function for AMER3 Gene

UniProtKB/Swiss-Prot Function: Regulator of the canonical Wnt signaling pathway. Acts by specifically binding phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2), translocating to the cell membrane (By similarity).

Gene Ontology (GO) - Molecular Function for AMER3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 24251807
GO:0008289 lipid binding IEA --
genes like me logo Genes that share ontologies with AMER3: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for AMER3 Gene

Localization for AMER3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for AMER3 Gene

Cell membrane; Peripheral membrane protein. Note=Translocates to the cell membrane following binding to PtdIns(4,5)P2. {ECO:0000250}.

Gene Ontology (GO) - Cellular Components for AMER3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IEA --
genes like me logo Genes that share ontologies with AMER3: view

No data available for Subcellular locations from COMPARTMENTS for AMER3 Gene

Pathways for AMER3 Gene

SuperPathways for AMER3 Gene

No Data Available

Gene Ontology (GO) - Biological Process for AMER3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016055 Wnt signaling pathway IEA --
genes like me logo Genes that share ontologies with AMER3: view

No data available for Pathways by source for AMER3 Gene

Transcripts for AMER3 Gene

mRNA/cDNA for AMER3 Gene

Unigene Clusters for AMER3 Gene

APC membrane recruitment protein 3:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for AMER3

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for AMER3
  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for AMER3 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3a · 3b · 3c · 3d
SP1: - - -
SP2: - -

Relevant External Links for AMER3 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for AMER3 Gene

mRNA expression in normal human tissues for AMER3 Gene

mRNA differential expression in normal tissues according to GTEx for AMER3 Gene

This gene is overexpressed in Brain - Cerebellar Hemisphere (9.5), Brain - Cerebellum (9.4), Brain - Cortex (5.3), and Brain - Frontal Cortex (BA9) (4.9).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for AMER3 Gene

SOURCE GeneReport for Unigene cluster for AMER3 Gene Hs.369289

genes like me logo Genes that share expressions with AMER3: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for AMER3 Gene

Orthologs for AMER3 Gene

This gene was present in the common ancestor of chordates.

Orthologs for AMER3 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia AMER3 36
  • 99 (a)
FAM123C 35
  • 99.03 (n)
  • 98.84 (a)
(Bos Taurus)
Mammalia AMER3 36
  • 67 (a)
FAM123C 35
  • 76.39 (n)
  • 70.32 (a)
(Canis familiaris)
Mammalia AMER3 35
  • 78.08 (n)
  • 71.99 (a)
AMER3 36
  • 66 (a)
(Mus musculus)
Mammalia Amer3 35
  • 75.01 (n)
  • 67.1 (a)
Amer3 16
Amer3 36
  • 63 (a)
(Monodelphis domestica)
Mammalia AMER3 36
  • 41 (a)
(Ornithorhynchus anatinus)
Mammalia AMER3 36
  • 54 (a)
(Rattus norvegicus)
Mammalia Amer3 35
  • 74.58 (n)
  • 66.88 (a)
(Gallus gallus)
Aves AMER3 36
  • 29 (a)
(Anolis carolinensis)
Reptilia AMER3 36
  • 49 (a)
(Danio rerio)
Actinopterygii AMER3 36
  • 20 (a)
Species with no ortholog for AMER3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for AMER3 Gene

Gene Tree for AMER3 (if available)
Gene Tree for AMER3 (if available)

Paralogs for AMER3 Gene

Paralogs for AMER3 Gene

genes like me logo Genes that share paralogs with AMER3: view

Variants for AMER3 Gene

Sequence variations from dbSNP and Humsavar for AMER3 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs272099 -- 130,765,824(-) atcca(C/G)cctca utr-variant-3-prime
rs272100 -- 130,766,657(-) tagcc(A/G)ggcaa utr-variant-3-prime
rs1134119 -- 130,766,098(+) GACTT(C/T)AGATG utr-variant-3-prime
rs1905235 - 130,763,090(+) ACCAA(C/T)CCCGG missense, reference
rs1991634 -- 130,760,736(-) CCCCT(C/T)TGTTC intron-variant

Relevant External Links for AMER3 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for AMER3 Gene

Disorders for AMER3 Gene

No disorders were found for AMER3 Gene.

No data available for UniProtKB/Swiss-Prot for AMER3 Gene

Publications for AMER3 Gene

  1. The WTX/AMER1 gene family: evolution, signature and function. (PMID: 20843316) Boutet A. … Schedl A. (BMC Evol. Biol. 2010) 2 3
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3
  5. Adenomatous polyposis coli (APC) membrane recruitment 3, a member of the APC membrane recruitment family of APC-binding proteins, is a positive regulator of Wnt-I^-catenin signalling. (PMID: 24251807) Brauburger K. … Behrens J. (FEBS J. 2014) 3

Products for AMER3 Gene

Sources for AMER3 Gene

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