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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

AMER2 Gene

protein-coding   GIFtS: 38
GCID: GC13M025736

APC Membrane Recruitment Protein 2

(Previous name: family with sequence similarity 123A)
(Previous symbol: FAM123A)
  Search for AMER2
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 4.2

Aliases
APC Membrane Recruitment Protein 21 2
FAM123A1 2 3
Family With Sequence Similarity 123A1 2
Protein FAM123A2 3
Amer23

External Ids:    HGNC: 263601   Entrez Gene: 2192872   Ensembl: ENSG000001655667   OMIM: 6146595   UniProtKB: Q8N7J23   
ORGUL members:    fRNAdb10:FR280259 FR072225      
H-InvDB12:HIT000221754    
NCBI13:U82310    
NONCODE14:n342374 n338603 n338602 n381995      
RNAdb15:EVF35668 HIV1706    

Export aliases for AMER2 gene to outside databases


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for AMER2 Gene: 
AMER2 (APC membrane recruitment protein 2) is a protein-coding gene, and is affiliated with the lncRNA class. GO annotations related to this gene include protein binding and phosphatidylinositol-4,5-bisphosphate binding. An important paralog of this gene is AMER3.

UniProtKB/Swiss-Prot: AMER2_HUMAN, Q8N7J2
Function: Negative regulator of the canonical Wnt signaling pathway involved in neuroectodermal patterning. Acts
by specifically binding phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2), translocating to the cell membrane
and interacting with key regulators of the canonical Wnt signaling pathway, such as components of the
beta-catenin destruction complex



fRNAdb sequence ontologies for AMER2 - the ORGUL cluster for this gene includes several descriptions:
nc_conserved_region - Non-coding region of sequence similarity by descent from a common ancestor.
ncRNA - An RNA transcript that does not encode for a protein rather the RNA molecule is the gene product.

View fRNAdb secondary structures for AMER2

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000013.10  NT_024524.14  NC_018924.2  
Regulatory elements:
   Search SABiosciences Regulatory transcription factor binding sites for AMER2
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidAMER2 promoter sequence
   Search SABiosciences Chromatin IP Primers for AMER2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat AMER2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 13q12.13   Ensembl cytogenetic band:  13q12.13   HGNC cytogenetic band: 13q12.13

AMER2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
AMER2 gene location

GeneLoc information about chromosome 13         GeneLoc Exon Structure

GeneLoc location for GC13M025736:  view genomic region     (about GC identifiers)

Start:
25,735,822 bp from pter      End:
25,746,426 bp from pter
Size:
10,605 bases      Orientation:
minus strand
ORGUL member locations:
Legend (see complete legend)

ORGUL Member Locations for AMER2

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: AMER2_HUMAN, Q8N7J2 (See protein sequence)
Recommended Name: APC membrane recruitment protein 2  
Size: 671 amino acids; 69507 Da
Subunit: Interacts with APC
Subcellular location: Cell membrane; Peripheral membrane protein. Note=Translocates to the cell membrane following
binding to PtdIns(4,5)P2
Sequence caution: Sequence=AAH32653.2; Type=Erroneous initiation; Note=Translation N-terminally shortened;
Sequence=AAH41392.1; Type=Frameshift; Positions=421, 485; Sequence=BAC05288.1; Type=Erroneous initiation;
Note=Translation N-terminally extended;
Secondary accessions: Q5RL80 Q5VX56 Q8N593 Q96NN5
Alternative splicing: 2 isoforms:  Q8N7J2-1   Q8N7J2-2   

Explore the universe of human proteins at neXtProt for AMER2: NX_Q8N7J2

Explore proteomics data for AMER2 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q8N7J2

  • AMER2 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    AMER2 Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_689917.2  NP_954589.1  

    ENSEMBL proteins: 
     ENSP00000350469   ENSP00000426528   ENSP00000371277  

    Human Recombinant Protein Products for AMER2: 
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    OriGene Custom MassSpec 
    OriGene Custom Protein Services for AMER2
    GenScript Custom Purified and Recombinant Proteins Services for AMER2
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp. 

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane IDA--

    AMER2 for ontologies           About GeneDecksing



    AMER2 Antibody Products: 
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    Novus Biologicals AMER2 Antibodies
    Abcam antibodies for AMER2
    Browse Antibodies at Cloud-Clone Corp. 
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    Search LSBio for Antibodies for AMER2 

    Assay Products for AMER2: 
    Browse Kits and Assays available from EMD Millipore
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    Browse ELISAs at Cloud-Clone Corp. 
    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    1 InterPro protein domain:
     IPR019003 Uncharacterised_FAM123

    Graphical View of Domain Structure for InterPro Entry Q8N7J2

    ProtoNet protein and cluster: Q8N7J2

    UniProtKB/Swiss-Prot: AMER2_HUMAN, Q8N7J2
    Similarity: Belongs to the Amer family


    AMER2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: AMER2_HUMAN, Q8N7J2
    Function: Negative regulator of the canonical Wnt signaling pathway involved in neuroectodermal patterning. Acts
    by specifically binding phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2), translocating to the cell membrane
    and interacting with key regulators of the canonical Wnt signaling pathway, such as components of the
    beta-catenin destruction complex

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI--
    GO:0005546phosphatidylinositol-4,5-bisphosphate binding IDA--
         
    AMER2 for ontologies           About GeneDecksing


    Phenotypes:
         3 GenomeRNAi human phenotypes for AMER2:
     Decreased number of cells in m  Increased HPV18 LCR reporter a  Increased gamma-H2AX phosphory 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for AMER2 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for AMER2

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for AMER2 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for AMER2 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat AMER2
    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate AMER2
    SwitchGear 3'UTR luciferase reporter plasmidAMER2 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for AMER2
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat AMER2

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for AMER2
    Sirion Biotech Customized adenovirus for overexpression of AMER2

    Clone
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    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for AMER2 (see all 11)
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript Custom all cDNA clones Services for AMER2
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for AMER2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat AMER2
    Sirion Biotech Customized lentivirus for stable overexpression of AMER2 
                         Customized lentivirus expression plasmids for stable overexpression of AMER2 

    Cell Line
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    GenScript Custom overexpressing Cell Line Services for AMER2
    Search LifeMap BioReagents cell lines for AMER2
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for AMER2


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for AMER2

    1 Interacting protein for AMER2 (Q8N7J23) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    RELAQ042063I2D: score=2 
    About this table

    Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007398ectoderm development ISS--
    GO:0016055Wnt receptor signaling pathway IEA--
    GO:0090090negative regulation of canonical Wnt receptor signaling pathway IMP--

    AMER2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for AMER2

    Search CenterWatch for drugs/clinical trials and news about AMER2

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    2 fRNAdb Secondary structures:


    REFSEQ mRNAs for AMER2 gene (2 alternative transcripts): 
    NM_152704.2  NM_199138.1  

    Unigene Cluster for AMER2:

    APC membrane recruitment protein 2
    Hs.528335  [show with all ESTs]
    Unigene Representative Sequence: AL832627
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000357816(uc001uqa.3 uc001uqc.3) ENST00000515384(uc001uqb.3)
    ENST00000381853
    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat AMER2
    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate AMER2
    SwitchGear 3'UTR luciferase reporter plasmidAMER2 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for AMER2
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat AMER2
    Clone
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    OriGene clones in human, mouse for AMER2 (see all 11)
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
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    DNA2.0 Custom Codon Optimized Gene Synthesis Service for AMER2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat AMER2
    Sirion Biotech Customized lentivirus for stable overexpression of AMER2 
                         Customized lentivirus expression plasmids for stable overexpression of AMER2 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for AMER2
    OriGene qSTAR qPCR primer pairs in human, mouse for AMER2
    Search SABiosciences RT2 qPCR Primer Assays in human, mouse, rat AMER2
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat AMER2
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat AMER2

    Additional mRNA sequence: 

    AK055049.1 AK055278.1 AK098343.1 AK098796.1 AL832627.1 BC032653.1 BC041392.1 

    4 DOTS entries:

    DT.412554  DT.410718  DT.100036438  DT.95089716 

    24/83 AceView cDNA sequences (see all 83):

    L13829 BC032653 BX114842 BM722339 NM_199138 AI934608 AK094378 BU740177 
    BM564862 AK098343 BU192669 NM_152704 AK098054 AL832627 BC041392 AA348540 
    BU167481 AL133784 BI914845 AA007154 L13831 AL832586 BQ434296 BM904008 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section
    See probesets specificity/sensitivity at GeneAnnot
    CGAP TAG: --


    AMER2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/5 selected tissues (see all 5) fully expand
     
     Peripheral Nervous System (Nervous System)    fully expand to see all 4 entries
             autonomic/sympathetic/ganglion   
     
     Nose (Sensory Organs)    fully expand to see all 2 entries
             sensory organ/nose/nasal cavity   
     
     Spinal Cord (Nervous System)
             spinal/ganglion/dorsal root ganglion   
     
     Neural Tube (Nervous System)
             Primitive Spinal Cord
     
     Brain (Nervous System)

    See AMER2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for AMER2

    SOURCE GeneReport for Unigene cluster: Hs.528335
        SABiosciences Custom PCR Arrays for AMER2
    Primer
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    OriGene qSTAR qPCR primer pairs in human, mouse for AMER2
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    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat AMER2
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat AMER2
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for AMER2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for AMER2 gene from 5/10 species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Amer25
    Fam123a1
    family with sequence similarity 123, member A1, 5 84.8(n)1
    81.22(a)1
      14 (31.62 cM)5
    721251  NM_028113.31  NP_082389.11 
     603782865 
    chicken
    (Gallus gallus)
    Aves FAM123A1 family with sequence similarity 123A 68.97(n)
    63.1(a)
      418939  XM_417133.3  XP_417133.3 
    lizard
    (Anolis carolinensis)
    Reptilia AMER26
    APC membrane recruitment protein 2
    41(a)
    1 ↔ 1
    3(189155641-189158228)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.154752 Transcribed sequences 78.88(n)    BX745438.1 
    zebrafish
    (Danio rerio)
    Actinopterygii fam123a1 family with sequence similarity 123A 49.79(n)
    43.63(a)
      100101649  NM_001100152.1  NP_001093622.1 


    ENSEMBL Gene Tree for AMER2 (if available)
    TreeFam Gene Tree for AMER2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for AMER2 gene
    AMER32  AMER12  

    AMER2 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/141 SNPs in AMER2 are shown (see all 141)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 13 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0364484
    A colorectal cancer sample4--see VAR_0364482 A T mis40--------
    rs1898124871,2
    --25742169(+) ACCTCC/TTAGTA 2 -- ds50010--------
    rs1463734401,2
    --25742371(+) AAAAAA/TACTTG 2 -- ds50010--------
    rs1384785201,2
    --25742593(+) GGTTTA/GGGGTG 2 -- ds50010--------
    rs95511811,2
    C--25742681(+) GAACCA/CGAGAA 2 -- ut31 ese30--------
    rs1818395391,2
    --25742758(+) ACCATC/TATCAT 2 -- ut310--------
    rs1431040011,2
    --25742762(+) TCATCA/TTGTCT 2 -- ut310--------
    rs36221,2
    C,F,A,H--25742889(+) CATGAA/GAAGGT 2 -- ut31 ese3100Minor allele frequency- G:0.20NS MN EA PA EU CA WA NA CSA 6452
    rs1865077441,2
    C--25742924(+) TGTATA/CTATTG 2 -- ut310--------
    rs1913488511,2
    --25742974(+) TGGGTC/GGGGGA 2 -- ut310--------

    HapMap Linkage Disequilibrium report for AMER2 (25735822 - 25746426 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for AMER2: --
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing AMER2
    DNA2.0 Custom Variant and Variant Library Synthesis for AMER2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    AMER2 for disorders           About MalaCards
    OMIM gene information: 614659    OMIM disorders: --


    AMER2 for disorders           About GeneDecksing


    Export disorders for AMER2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for AMER2 gene, integrated from 9 sources (see all 16):
    (articles sorted by number of sources associating them with AMER2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The WTX/AMER1 gene family: evolution, signature and function. (PubMed id 20843316)1, 2, 3 Boutet A.... Schedl A. (2010)
    2. Amer2 protein is a novel negative regulator of Wnt/beta-Catenin signaling involved in neuroectodermal patterning. (PubMed id 22128170)1, 2 Pfister A.S.... Behrens J. (2012)
    3. The DNA sequence and analysis of human chromosome 13. (PubMed id 15057823)1, 2 Dunham A.... Ross M.T. (2004)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    6. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (2002)
    7. FAM123A binds to microtubules and inhibits the guanine nucleotide exchange factor ARHGEF2 to decrease actomyosin contractility. (PubMed id 22949735)1 Siesser P.F....Major M.B. (2012)
    8. Amer2 protein interacts with EB1 protein and adenomato us polyposis coli (APC) and controls microtubule stability and cell migration. (PubMed id 22898821)1 Pfister A.S....Behrens J. (2012)
    9. AMER1 regulates the distribution of the tumor suppressor APC between microtubules and the plasma membrane. (PubMed id 17925383)2 Grohmann A....Behrens J. (2007)
    10. The consensus coding sequences of human breast and colorectal cancers. (PubMed id 16959974)2 Sjoeblom T.... Velculescu V.E. (2006)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 219287 HGNC: 26360 AceView: FLJ25477 Ensembl:ENSG00000165566 euGenes: HUgn219287
    ECgene: AMER2 H-InvDB: AMER2

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for AMER2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for AMER2 gene:
    Search GeneIP for patents involving AMER2

    GeneCards and IP:
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    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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