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Aliases for AMER2 Gene

Subcategory (RNA class) for AMER2 Gene

lncRNA

Aliases for AMER2 Gene

  • APC Membrane Recruitment Protein 2 2 3
  • Family With Sequence Similarity 123A 2 3
  • Protein FAM123A 3 4
  • FAM123A 3 4
  • FAM123A, 6
  • Amer2 4

External Ids for AMER2 Gene

ORGUL Members for AMER2 Gene

Previous Symbols for AMER2 Gene

  • FAM123A

Summaries for AMER2 Gene

GeneCards Summary for AMER2 Gene

AMER2 (APC Membrane Recruitment Protein 2) is a Protein Coding gene, and belongs to the lncRNA class. Diseases associated with AMER2 include adenomatous polyposis coli and colorectal cancer. GO annotations related to this gene include phosphatidylinositol-4,5-bisphosphate binding. An important paralog of this gene is AMER1.

UniProtKB/Swiss-Prot for AMER2 Gene

  • Negative regulator of the canonical Wnt signaling pathway involved in neuroectodermal patterning. Acts by specifically binding phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2), translocating to the cell membrane and interacting with key regulators of the canonical Wnt signaling pathway, such as components of the beta-catenin destruction complex.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for AMER2 Gene

Genomics for AMER2 Gene

Genomic Location for AMER2 Gene

Start:
25,161,679 bp from pter
End:
25,172,288 bp from pter
Size:
10,610 bases
Orientation:
Minus strand

Genomic View for AMER2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for AMER2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for AMER2 Gene

No data available for Regulatory Elements for AMER2 Gene

Proteins for AMER2 Gene

  • Protein details for AMER2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N7J2-AMER2_HUMAN
    Recommended name:
    APC membrane recruitment protein 2
    Protein Accession:
    Q8N7J2
    Secondary Accessions:
    • Q5RL80
    • Q5VX56
    • Q8N593
    • Q96NN5

    Protein attributes for AMER2 Gene

    Size:
    671 amino acids
    Molecular mass:
    69507 Da
    Quaternary structure:
    • Interacts with APC.
    SequenceCaution:
    • Sequence=AAH32653.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=AAH41392.1; Type=Frameshift; Positions=421, 485; Evidence={ECO:0000305}; Sequence=BAC05288.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for AMER2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for AMER2 Gene

Proteomics data for AMER2 Gene at MOPED

Post-translational modifications for AMER2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for AMER2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for AMER2 Gene

Domains for AMER2 Gene

Protein Domains for AMER2 Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

Q8N7J2

UniProtKB/Swiss-Prot:

AMER2_HUMAN
Family:
  • Belongs to the Amer family.:
    • Q8N7J2
genes like me logo Genes that share domains with AMER2: view

No data available for Gene Families and Suggested Antigen Peptide Sequences for AMER2 Gene

Function for AMER2 Gene

Molecular function for AMER2 Gene

UniProtKB/Swiss-Prot Function: Negative regulator of the canonical Wnt signaling pathway involved in neuroectodermal patterning. Acts by specifically binding phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2), translocating to the cell membrane and interacting with key regulators of the canonical Wnt signaling pathway, such as components of the beta-catenin destruction complex.

Gene Ontology (GO) - Molecular Function for AMER2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 22128170
GO:0005546 phosphatidylinositol-4,5-bisphosphate binding IDA 22128170
genes like me logo Genes that share ontologies with AMER2: view
genes like me logo Genes that share phenotypes with AMER2: view

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for AMER2 Gene

Localization for AMER2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for AMER2 Gene

Cell membrane; Peripheral membrane protein. Note=Translocates to the cell membrane following binding to PtdIns(4,5)P2.

Gene Ontology (GO) - Cellular Components for AMER2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IDA 22128170
genes like me logo Genes that share ontologies with AMER2: view

No data available for Subcellular locations from COMPARTMENTS for AMER2 Gene

Pathways for AMER2 Gene

SuperPathways for AMER2 Gene

No Data Available

Interacting Proteins for AMER2 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000426528%0d%0a9606.ENSP00000257430%0d%0a
Selected Interacting proteins: ENSP00000426528 Q8N7J2-AMER2_HUMAN for AMER2 Gene via STRING I2D

Gene Ontology (GO) - Biological Process for AMER2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007398 ectoderm development ISS --
GO:0016055 Wnt signaling pathway IEA --
GO:0090090 negative regulation of canonical Wnt signaling pathway IMP 22128170
genes like me logo Genes that share ontologies with AMER2: view

No data available for Pathways by source for AMER2 Gene

Transcripts for AMER2 Gene

Unigene Clusters for AMER2 Gene

APC membrane recruitment protein 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for AMER2 Gene

No ASD Table

Relevant External Links for AMER2 Gene

GeneLoc Exon Structure for
AMER2
ECgene alternative splicing isoforms for
AMER2

Expression for AMER2 Gene

mRNA expression in normal human tissues for AMER2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for AMER2 Gene

This gene is overexpressed in Brain - Hippocampus (5.5), Brain - Spinal cord (cervical c-1) (4.9), Brain - Amygdala (4.9), Brain - Putamen (basal ganglia) (4.8), Brain - Caudate (basal ganglia) (4.7), and Brain - Substantia nigra (4.5).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for AMER2 Gene

SOURCE GeneReport for Unigene cluster for AMER2 Gene Hs.528335

genes like me logo Genes that share expressions with AMER2: view

No data available for mRNA Expression by UniProt/SwissProt for AMER2 Gene

Orthologs for AMER2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for AMER2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia AMER2 36
  • 99 (a)
OneToOne
FAM123A 35
  • 99.46 (n)
  • 99.46 (a)
dog
(Canis familiaris)
Mammalia AMER2 36
  • 77 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Amer2 35
  • 84.16 (n)
  • 80.58 (a)
Amer2 16
Amer2 36
  • 70 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia AMER2 36
  • 65 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Amer2 35
  • 85.08 (n)
  • 80.88 (a)
chicken
(Gallus gallus)
Aves AMER2 36
  • 55 (a)
OneToOne
FAM123A 35
  • 69.03 (n)
  • 63.37 (a)
lizard
(Anolis carolinensis)
Reptilia AMER2 36
  • 41 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia amer2 35
  • 57.96 (n)
  • 50.09 (a)
Str.15475 35
zebrafish
(Danio rerio)
Actinopterygii amer2 35
  • 51.24 (n)
  • 45.91 (a)
amer2 36
  • 31 (a)
OneToOne
Species with no ortholog for AMER2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for AMER2 Gene

ENSEMBL:
Gene Tree for AMER2 (if available)
TreeFam:
Gene Tree for AMER2 (if available)

Paralogs for AMER2 Gene

Paralogs for AMER2 Gene

genes like me logo Genes that share paralogs with AMER2: view

Variants for AMER2 Gene

Sequence variations from dbSNP and Humsavar for AMER2 Gene

SNP ID Clin Chr 13 pos Sequence Context AA Info Type MAF
rs3622 -- 25,168,751(+) CATGA(A/G)AAGGT utr-variant-3-prime
rs1052565 -- 25,169,441(-) CTGAG(C/T)AGGGA utr-variant-3-prime
rs1052933 -- 25,162,185(-) AGCTT(C/T)CCTGA utr-variant-3-prime
rs1361568 -- 25,165,856(-) GGCTC(C/T)GTCCG utr-variant-3-prime
rs1361569 -- 25,165,685(-) GTTTT(C/T)TGCTG utr-variant-3-prime

Relevant External Links for AMER2 Gene

HapMap Linkage Disequilibrium report
AMER2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for AMER2 Gene

Disorders for AMER2 Gene

genes like me logo Genes that share disorders with AMER2: view

No data available for UniProtKB/Swiss-Prot for AMER2 Gene

Publications for AMER2 Gene

  1. The WTX/AMER1 gene family: evolution, signature and function. (PMID: 20843316) Boutet A. … Schedl A. (BMC Evol. Biol. 2010) 2 3 4
  2. Amer2 protein is a novel negative regulator of Wnt/beta-Catenin signaling involved in neuroectodermal patterning. (PMID: 22128170) Pfister A.S. … Behrens J. (J. Biol. Chem. 2012) 3 4
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  4. The DNA sequence and analysis of human chromosome 13. (PMID: 15057823) Dunham A. … Ross M.T. (Nature 2004) 3 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4

Products for AMER2 Gene

Sources for AMER2 Gene

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