Subcategory (RNA class) for AMER2 Gene
Aliases for AMER2 Gene
External Ids for AMER2 Gene
Previous HGNC Symbols for AMER2 Gene
Previous GeneCards Identifiers for AMER2 Gene
GeneCards Summary for AMER2 Gene
AMER2 (APC Membrane Recruitment Protein 2) is a Protein Coding gene, and is affiliated with the lncRNA class. Diseases associated with AMER2 include adenomatous polyposis coli and colorectal cancer. GO annotations related to this gene include phosphatidylinositol-4,5-bisphosphate binding. An important paralog of this gene is AMER1.
UniProtKB/Swiss-Prot for AMER2 Gene
Negative regulator of the canonical Wnt signaling pathway involved in neuroectodermal patterning. Acts by specifically binding phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2), translocating to the cell membrane and interacting with key regulators of the canonical Wnt signaling pathway, such as components of the beta-catenin destruction complex.