Free for academic non-profit institutions. Other users need a Commercial license

Aliases for AMER2 Gene

Subcategory (RNA class) for AMER2 Gene

lncRNA

Aliases for AMER2 Gene

  • APC Membrane Recruitment Protein 2 2 3 5
  • Family With Sequence Similarity 123A 2 3
  • Protein FAM123A 3 4
  • FAM123A 3 4
  • Amer2 4

External Ids for AMER2 Gene

ORGUL Members for AMER2 Gene

Previous HGNC Symbols for AMER2 Gene

  • FAM123A

Previous GeneCards Identifiers for AMER2 Gene

  • GC13M025736

Summaries for AMER2 Gene

GeneCards Summary for AMER2 Gene

AMER2 (APC Membrane Recruitment Protein 2) is a Protein Coding gene, and is affiliated with the lncRNA class. GO annotations related to this gene include phosphatidylinositol-4,5-bisphosphate binding. An important paralog of this gene is AMER1.

UniProtKB/Swiss-Prot for AMER2 Gene

  • Negative regulator of the canonical Wnt signaling pathway involved in neuroectodermal patterning. Acts by specifically binding phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2), translocating to the cell membrane and interacting with key regulators of the canonical Wnt signaling pathway, such as components of the beta-catenin destruction complex.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for AMER2 Gene

Genomics for AMER2 Gene

Regulatory Elements for AMER2 Gene

Enhancers for AMER2 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around AMER2 on UCSC Golden Path with GeneCards custom track

Genomic Location for AMER2 Gene

Chromosome:
13
Start:
25,161,679 bp from pter
End:
25,172,324 bp from pter
Size:
10,646 bases
Orientation:
Minus strand

Genomic View for AMER2 Gene

Genes around AMER2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
AMER2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for AMER2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for AMER2 Gene

Proteins for AMER2 Gene

  • Protein details for AMER2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N7J2-AMER2_HUMAN
    Recommended name:
    APC membrane recruitment protein 2
    Protein Accession:
    Q8N7J2
    Secondary Accessions:
    • Q5RL80
    • Q5VX56
    • Q8N593
    • Q96NN5

    Protein attributes for AMER2 Gene

    Size:
    671 amino acids
    Molecular mass:
    69507 Da
    Quaternary structure:
    • Interacts with APC.
    SequenceCaution:
    • Sequence=AAH32653.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=AAH41392.1; Type=Frameshift; Positions=421, 485; Evidence={ECO:0000305}; Sequence=BAC05288.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for AMER2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for AMER2 Gene

Proteomics data for AMER2 Gene at MOPED

Post-translational modifications for AMER2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for AMER2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for AMER2 Gene

Domains & Families for AMER2 Gene

Protein Domains for AMER2 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for AMER2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8N7J2

UniProtKB/Swiss-Prot:

AMER2_HUMAN :
  • Belongs to the Amer family.
Family:
  • Belongs to the Amer family.
genes like me logo Genes that share domains with AMER2: view

No data available for Gene Families for AMER2 Gene

Function for AMER2 Gene

Molecular function for AMER2 Gene

UniProtKB/Swiss-Prot Function:
Negative regulator of the canonical Wnt signaling pathway involved in neuroectodermal patterning. Acts by specifically binding phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2), translocating to the cell membrane and interacting with key regulators of the canonical Wnt signaling pathway, such as components of the beta-catenin destruction complex.

Gene Ontology (GO) - Molecular Function for AMER2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 22128170
GO:0008013 beta-catenin binding IBA --
genes like me logo Genes that share ontologies with AMER2: view
genes like me logo Genes that share phenotypes with AMER2: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for AMER2 Gene

Localization for AMER2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for AMER2 Gene

Cell membrane; Peripheral membrane protein. Note=Translocates to the cell membrane following binding to PtdIns(4,5)P2.

No data available for Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for AMER2 Gene

Pathways & Interactions for AMER2 Gene

SuperPathways for AMER2 Gene

No Data Available

Interacting Proteins for AMER2 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000426528%0d%0a9606.ENSP00000257430%0d%0a
Selected Interacting proteins: ENSP00000426528 Q8N7J2-AMER2_HUMAN for AMER2 Gene via STRING I2D

Gene Ontology (GO) - Biological Process for AMER2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0090090 negative regulation of canonical Wnt signaling pathway IMP 22128170
genes like me logo Genes that share ontologies with AMER2: view

No data available for Pathways by source and SIGNOR curated interactions for AMER2 Gene

Drugs & Compounds for AMER2 Gene

No Compound Related Data Available

Transcripts for AMER2 Gene

Unigene Clusters for AMER2 Gene

APC membrane recruitment protein 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for AMER2 Gene

No ASD Table

Relevant External Links for AMER2 Gene

GeneLoc Exon Structure for
AMER2
ECgene alternative splicing isoforms for
AMER2

Expression for AMER2 Gene

mRNA expression in normal human tissues for AMER2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for AMER2 Gene

This gene is overexpressed in Brain - Hippocampus (x5.5), Brain - Spinal cord (cervical c-1) (x4.9), Brain - Amygdala (x4.9), Brain - Putamen (basal ganglia) (x4.8), Brain - Caudate (basal ganglia) (x4.7), and Brain - Substantia nigra (x4.5).

Protein differential expression in normal tissues from HIPED for AMER2 Gene

This gene is overexpressed in Liver (24.0), Frontal cortex (13.2), Fetal Brain (12.7), and Heart (7.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for AMER2 Gene



SOURCE GeneReport for Unigene cluster for AMER2 Gene Hs.528335

genes like me logo Genes that share expression patterns with AMER2: view

Protein tissue co-expression partners for AMER2 Gene

- Elite partner

Primer Products

No data available for mRNA Expression by UniProt/SwissProt for AMER2 Gene

Orthologs for AMER2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for AMER2 Gene

Organism Taxonomy Gene Similarity Type Details
mouse
(Mus musculus)
Mammalia Amer2 35
  • 84.16 (n)
  • 80.58 (a)
Amer2 16
Amer2 36
  • 70 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia FAM123A 35
  • 99.46 (n)
  • 99.46 (a)
AMER2 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Amer2 35
  • 85.08 (n)
  • 80.88 (a)
dog
(Canis familiaris)
Mammalia AMER2 36
  • 77 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia AMER2 36
  • 65 (a)
OneToOne
chicken
(Gallus gallus)
Aves FAM123A 35
  • 69.03 (n)
  • 63.37 (a)
AMER2 36
  • 55 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia AMER2 36
  • 41 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia amer2 35
  • 57.96 (n)
  • 50.09 (a)
Str.15475 35
zebrafish
(Danio rerio)
Actinopterygii amer2 35
  • 51.24 (n)
  • 45.91 (a)
amer2 36
  • 31 (a)
OneToOne
Species with no ortholog for AMER2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for AMER2 Gene

ENSEMBL:
Gene Tree for AMER2 (if available)
TreeFam:
Gene Tree for AMER2 (if available)

Paralogs for AMER2 Gene

Paralogs for AMER2 Gene

genes like me logo Genes that share paralogs with AMER2: view

Variants for AMER2 Gene

Sequence variations from dbSNP and Humsavar for AMER2 Gene

SNP ID Clin Chr 13 pos Sequence Context AA Info Type
rs2282406 - 25,169,643(+) GCTCT(C/G)ATGGT reference, missense
VAR_036448 A colorectal cancer sample
rs3622 -- 25,168,751(+) CATGA(A/G)AAGGT utr-variant-3-prime
rs1052565 -- 25,169,441(-) CTGAG(C/T)AGGGA utr-variant-3-prime
rs1052933 -- 25,162,185(-) AGCTT(C/T)CCTGA utr-variant-3-prime

Variation tolerance for AMER2 Gene

Residual Variation Intolerance Score: 67% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.55; 64.92% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Structural Variations from Database of Genomic Variants (DGV) and Relevant External Links for AMER2 Gene

Disorders for AMER2 Gene

Relevant External Links for AMER2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
AMER2

No disorders were found for AMER2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for AMER2 Gene

Publications for AMER2 Gene

  1. The WTX/AMER1 gene family: evolution, signature and function. (PMID: 20843316) Boutet A. … Schedl A. (BMC Evol. Biol. 2010) 2 3 4 67
  2. Amer2 protein is a novel negative regulator of Wnt/beta-Catenin signaling involved in neuroectodermal patterning. (PMID: 22128170) Pfister A.S. … Behrens J. (J. Biol. Chem. 2012) 3
  3. Amer2 protein interacts with EB1 protein and adenomatous polyposis coli (APC) and controls microtubule stability and cell migration. (PMID: 22898821) Pfister A.S. … Behrens J. (J. Biol. Chem. 2012) 3
  4. FAM123A binds to microtubules and inhibits the guanine nucleotide exchange factor ARHGEF2 to decrease actomyosin contractility. (PMID: 22949735) Siesser P.F. … Major M.B. (Sci Signal 2012) 3
  5. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3

Products for AMER2 Gene

Sources for AMER2 Gene

Content