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AMER1 Gene

protein-coding   GIFtS: 42
GCID: GC0XM063406

APC Membrane Recruitment Protein 1

(Previous name: family with sequence similarity 123B)
(Previous symbol: FAM123B)
  See AMER1-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
APC Membrane Recruitment Protein 11 2     Protein FAM123B2 3
FAM123B1 2 3 5     Wilms Tumor Gene On The X Chromosome Protein2 3
WTX2 3 5     OSCS2 5
Family With Sequence Similarity 123B1 2     RP11-403E24.22
Adenomatous Polyposis Coli Membrane Recruitment 11 2     Amer13
Wilms Tumor On The X1 2     

External Ids:    HGNC: 268371   Entrez Gene: 1392852   Ensembl: ENSG000001846757   OMIM: 3006475   UniProtKB: Q5JTC63   

Export aliases for AMER1 gene to outside databases


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for AMER1 Gene:
The protein encoded by this gene upregulates trancriptional activation by the Wilms tumor protein and interacts
with many other proteins, including CTNNB1, APC, AXIN1, and AXIN2. Defects in this gene are a cause of
osteopathia striata with cranial sclerosis (OSCS). (provided by RefSeq, May 2010)

GeneCards Summary for AMER1 Gene:
AMER1 (APC membrane recruitment protein 1) is a protein-coding gene. Diseases associated with AMER1 include osteopathia striata cranial sclerosis, and wilms tumor. GO annotations related to this gene include phosphatidylinositol-4,5-bisphosphate binding and beta-catenin binding. An important paralog of this gene is AMER2.

UniProtKB/Swiss-Prot: AMER1_HUMAN, Q5JTC6
Function: Regulator of the canonical Wnt signaling pathway. Acts by specifically binding phosphatidylinositol
4,5-bisphosphate (PtdIns(4,5)P2), translocating to the cell membrane and interacting with key regulators of the
canonical Wnt signaling pathway, such as components of the beta-catenin destruction complex. Acts both as a
positive and negative regulator of the Wnt signaling pathway, depending on the context: acts as a positive
regulator by promoting LRP6 phosphorylation. Also acts as a negative regulator by acting as a scaffold protein
for the beta-catenin destruction complex and promoting stabilization of Axin at the cell membrane. Promotes
CTNNB1 ubiquitination and degradation. Involved in kidney development




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000023.10  NT_011651.18  NC_018934.2  
Regulatory elements:
   Search for regulatory transcription factor binding sites for AMER1
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidAMER1 promoter sequence
   Search Chromatin IP Primers for AMER1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat AMER1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: Xq11.2   Ensembl cytogenetic band:  Xq11.2   HGNC cytogenetic band: Xq11.1

AMER1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
AMER1 gene location

GeneLoc information about chromosome X         GeneLoc Exon Structure

GeneLoc location for GC0XM063406:  view genomic region     (about GC identifiers)

Start:
63,404,997 bp from pter      End:
63,425,624 bp from pter
Size:
20,628 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: AMER1_HUMAN, Q5JTC6 (See protein sequence)
Recommended Name: APC membrane recruitment protein 1  
Size: 1135 amino acids; 124029 Da
Subunit: Interacts with CTNNB1, AXIN1, LRP6, KEAP1, APC and BTRC. Interacts with SCF (SKP1-CUL1-F-box protein) E3
ubiquitin-protein ligase complexes containing BTRC and/or FBXW11. Identified in the beta-catenin destruction
complex containing CTNNB1, APC, AXIN1 and AXIN2. Interacts with WT1
Miscellaneous: Inactivated in approximately one-third of Wilms tumors
Secondary accessions: A2IB86 Q8N885
Alternative splicing: 2 isoforms:  Q5JTC6-1   Q5JTC6-2   (Ref.2 (BAC04964) sequence is in conflict in position: 786:I->R)

Explore the universe of human proteins at neXtProt for AMER1: NX_Q5JTC6

Explore proteomics data for AMER1 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See AMER1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_689637.3  
    ENSEMBL proteins: 
     ENSP00000364003   ENSP00000329117   ENSP00000384722  
    Reactome Protein details: Q5JTC6

    AMER1 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
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    Browse Proteins at Cloud-Clone Corp.

     
    Search eBioscience for Proteins for AMER1 

     
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    antibodies-online peptides for AMER1

    AMER1 Antibody Products:

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    antibodies-online antibodies for AMER1 (29 products) 

    AMER1 Assay Products:

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    antibodies-online kits for AMER1 (4 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR019003 Uncharacterised_FAM123

    Graphical View of Domain Structure for InterPro Entry Q5JTC6

    ProtoNet protein and cluster: Q5JTC6

    UniProtKB/Swiss-Prot: AMER1_HUMAN, Q5JTC6
    Similarity: Belongs to the Amer family


    Find genes that share domains with AMER1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: AMER1_HUMAN, Q5JTC6
    Function: Regulator of the canonical Wnt signaling pathway. Acts by specifically binding phosphatidylinositol
    4,5-bisphosphate (PtdIns(4,5)P2), translocating to the cell membrane and interacting with key regulators of the
    canonical Wnt signaling pathway, such as components of the beta-catenin destruction complex. Acts both as a
    positive and negative regulator of the Wnt signaling pathway, depending on the context: acts as a positive
    regulator by promoting LRP6 phosphorylation. Also acts as a negative regulator by acting as a scaffold protein
    for the beta-catenin destruction complex and promoting stabilization of Axin at the cell membrane. Promotes
    CTNNB1 ubiquitination and degradation. Involved in kidney development

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI17925383
    GO:0005546phosphatidylinositol-4,5-bisphosphate binding IMP17925383
    GO:0008013beta-catenin binding IDA--
         
    Find genes that share ontologies with AMER1           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for AMER1:
     Increased G1 DNA content 

         13 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Amer1):
     adipose tissue  cardiovascular system  cellular  craniofacial  embryogenesis 
     growth/size/body  hematopoietic system  homeostasis/metabolism  immune system  limbs/digits/tail 
     mortality/aging  renal/urinary system  skeleton 

    Find genes that share phenotypes with AMER1           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Amer1tm1.2Nbar for AMER1

       genOway: Develop your customized and physiologically relevant rodent model for AMER1

    miRNA
    Products:
        
    miRTarBase miRNAs that target AMER1:
    hsa-mir-484 (MIRT042310), hsa-mir-16-5p (MIRT051169), hsa-mir-29c-3p (MIRT020401)

    Block miRNA regulation of human, mouse, rat AMER1 using miScript Target Protectors
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    DNA2.0 Custom Codon Optimized Gene Synthesis Service for AMER1
    Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat AMER1
    Addgene plasmids for AMER1 

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for AMER1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    AMER1_HUMAN, Q5JTC6: Cytoplasm. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Nucleus.
    Note=Shuttles between nucleus and cytoplasm. Detected in nuclear paraspeckles that are found close to splicing
    speckles. Translocates to the cell membrane following binding to PtdIns(4,5)P2

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--
    GO:0005829cytosol TAS--
    GO:0005886plasma membrane IDA17925383

    Find genes that share ontologies with AMER1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for AMER1 About    
    See pathways by source

    SuperPathContained pathways About
    1CDK-mediated phosphorylation and removal of Cdc6
    Degradation of beta-catenin by the destruction complex0.73
    Beta-catenin phosphorylation cascade0.00
    2beta-catenin independent WNT signaling
    Signaling by Wnt0.79
    3Signaling by GPCR
    Signal Transduction0.58
    4Wnt / Hedgehog / Notch
    Wnt / Hedgehog / Notch
    5Canonical Wnt signaling pathway
    Canonical Wnt signaling pathway


    Find genes that share SuperPaths with AMER1           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Cell Signaling Technology (CST) Pathway for AMER1
        Wnt / Hedgehog / Notch

    1 BioSystems Pathway for AMER1
        Canonical Wnt signaling pathway

    3 Reactome Pathways for AMER1
        disassembly of the destruction complex and recruitment of AXIN to the membrane
    Degradation of beta-catenin by the destruction complex
    Beta-catenin phosphorylation cascade


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for AMER1
    Interactions:

        Search GeneGlobe Interaction Network for AMER1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for AMER1 (Q5JTC61, 3 ENSP000003291174) via UniProtKB, MINT, STRING, and/or I2D (see all 55)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    AXIN1O151693, ENSP000002623204I2D: score=1 STRING: ENSP00000262320
    BTRCQ9Y2973, ENSP000003592064I2D: score=1 STRING: ENSP00000359206
    KEAP1Q141453, ENSP000001711114I2D: score=1 STRING: ENSP00000171111
    CTNNB1P352223, ENSP000003444564I2D: score=1 STRING: ENSP00000344456
    FBXW11Q9UKB13, ENSP000002650944I2D: score=1 STRING: ENSP00000265094
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001822kidney development ----
    GO:0016055Wnt signaling pathway IEA--
    GO:0060348bone development IEA--
    GO:0060612adipose tissue development IEA--
    GO:0060828regulation of canonical Wnt signaling pathway IMP17925383

    Find genes that share ontologies with AMER1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for AMER1



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for AMER1 gene: 
    NM_152424.3  

    Unigene Cluster for AMER1:

    APC membrane recruitment protein 1
    Hs.314225  [show with all ESTs]
    Unigene Representative Sequence: NM_152424
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000374869 ENST00000330258(uc004dvo.3) ENST00000403336
    miRNA
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    Predesigned siRNA for gene silencing in human, mouse, rat AMER1
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      QuantiTect SYBR Green Assays in human, mouse, rat AMER1
      QuantiFast Probe-based Assays in human, mouse, rat AMER1

    Additional mRNA sequence: 

    AK097146.1 AL833759.1 EF186024.1 

    2 DOTS entries:

    DT.40268053  DT.95258665 

    7 AceView cDNA sequences:

    NM_152424 AL833759 BF062529 AK097146 AW752321 AW796931 T11961 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    AMER1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    AMER1 Expression
    About this image

    AMER1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    AMER1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.314225

    UniProtKB/Swiss-Prot: AMER1_HUMAN, Q5JTC6
    Tissue specificity: Detected in fetal and adult kidney, brain and spleen

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for AMER1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for AMER1 gene from Selected species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Amer11 , 5 family with sequence similarity 123, member B5
    APC membrane recruitment 11
    83.47(n)1
    80.65(a)1
      X (41.99 cM)5
    723451  NM_175179.41  NP_780388.21 
     954203185 
    chicken
    (Gallus gallus)
    Aves FAM123B1 family with sequence similarity 123B 53.02(n)
    44.15(a)
      422314  XM_420290.4  XP_420290.4 
    lizard
    (Anolis carolinensis)
    Reptilia AMER16
    APC membrane recruitment protein 1
    44(a)
    1 ↔ 1
    GL343875.1(40366-46266)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.159092 Xenopus laevis transcribed sequences 74.02(n)    CF547470.1 
    zebrafish
    (Danio rerio)
    Actinopterygii amer16
    APC membrane recruitment protein 1
    28(a)
    1 ↔ 1
    5(23797756-23802389) ENSDARG00000079624


    ENSEMBL Gene Tree for AMER1 (if available)
    TreeFam Gene Tree for AMER1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for AMER1 gene
    AMER22  AMER32  

    Find genes that share paralogs with AMER1           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for AMER1 (see all 332)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr X posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1847788571,2
    --63411534(+) AGCTAC/TCTGGC 1 -- ds50010--------
    rs1891957471,2
    --63411562(+) GTCCCA/GGATAA 1 -- ds50010--------
    rs1818320211,2
    --63411580(+) CATTCC/TTGCAG 1 -- ds50010--------
    rs1862034281,2
    --63411916(+) ACCACA/CTCCTT 1 -- ds50010--------
    rs38107011,2
    C,F,H--63412085(+) CAGGCA/CGTGCA 1 -- ut31 ese34Minor allele frequency- C:0.01NS EA 418
    rs2007179851,2
    C--63412334(+) TTATT-/CCCCCC 1 -- ut310--------
    rs1891690331,2
    --63412336(+) ATTCCC/TCCCCA 1 -- ut310--------
    rs1815769841,2
    --63412435(+) ACATAC/TACATA 1 -- ut310--------
    rs1862022091,2
    --63412722(+) CCTGAC/TAGTGC 1 -- ut310--------
    rs59647361,2
    C,F,A,H--63412776(+) GGACAT/CGGTTG 1 -- ut31 ese315Minor allele frequency- C:0.28NS EA WA NA CSA 1610

    HapMap Linkage Disequilibrium report for AMER1 (63404997 - 63425624 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for AMER1: --
    Locus Specific Mutation Databases (LSDB): AMER1

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing AMER1
    DNA2.0 Custom Variant and Variant Library Synthesis for AMER1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 300647   
    OMIM disorders: 300373  
    UniProtKB/Swiss-Prot: AMER1_HUMAN, Q5JTC6
  • Osteopathia striata with cranial sclerosis (OSCS) [MIM:300373]: An X-linked dominant sclerosing bone
    dysplasia that presents in females with macrocephaly, cleft palate, facial palsy, conductive hearing loss, mild
    learning disabilities, sclerosis of the long bones and skull. Longitudinal striations are visible on radiographs
    of the long bones, pelvis, and scapulae (osteopathia striata). In males this entity is usually associated with
    fetal or neonatal lethality. Occasional surviving males have, in addition to hyperostosis, cardiac, intestinal,
    and genitourinary malformations. Note=The disease is caused by mutations affecting the gene represented in this
    entry

  • 2 diseases for AMER1:    
    About MalaCards
    osteopathia striata cranial sclerosis    wilms tumor


    Find genes that share disorders with AMER1           About GenesLikeMe


    Export disorders for AMER1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for AMER1 gene, integrated from 10 sources (see all 43):
    (articles sorted by number of sources associating them with AMER1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Amer1/WTX couples Wnt-induced formation of PtdIns(4,5)P2 to LRP6 phosphorylation. (PubMed id 21304492)1, 2, 3 Tanneberger K.... Behrens J. (EMBO J. 2011)
    2. Structural and functional characterization of the Wnt inhibitor APC membrane recruitment 1 (Amer1). (PubMed id 21498506)1, 2, 3 Tanneberger K....Behrens J. (J. Biol. Chem. 2011)
    3. The WTX/AMER1 gene family: evolution, signature and function. (PubMed id 20843316)1, 2, 3 Boutet A.... Schedl A. (BMC Evol. Biol. 2010)
    4. The tumor suppressor WTX shuttles to the nucleus and modulates WT1 activity. (PubMed id 19416806)1, 2 Rivera M.N.... Haber D.A. (Proc. Natl. Acad. Sci. U.S.A. 2009)
    5. Germline mutations in WTX cause a sclerosing skeletal dysplasia but do not predispose to tumorigenesis. (PubMed id 19079258)1, 2 Jenkins Z.A.... Robertson S.P. (Nat. Genet. 2009)
    6. AMER1 regulates the distribution of the tumor suppressor APC between microtubules and the plasma membrane. (PubMed id 17925383)1, 2 Grohmann A.... Behrens J. (J. Cell Sci. 2007)
    7. Wilms tumor suppressor WTX negatively regulates WNT/beta-catenin signaling. (PubMed id 17510365)1, 2 Major M.B.... Moon R.T. (Science 2007)
    8. An X chromosome gene, WTX, is commonly inactivated in Wilms tumor. (PubMed id 17204608)1, 2 Rivera M.N.... Haber D.A. (Science 2007)
    9. The DNA sequence of the human X chromosome. (PubMed id 15772651)1, 2 Ross M.T.... Bentley D.R. (Nature 2005)
    10. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 139285 HGNC: 26837 AceView: FLJ39827 Ensembl:ENSG00000184675 euGenes: HUgn139285
    ECgene: AMER1 H-InvDB: AMER1

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for AMER1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for AMER1 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for AMER1 gene:
    Search GeneIP for patents involving AMER1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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