Show Advanced Search
""
""

Advanced Search (alpha)

""
 
Search By
Section
for


Category   Symbol Source: HGNC EntrezGene Ensembl
GIFtS
Search by expression pattern


AMELY Gene

protein-coding   GIFtS: 41

GC0YM006777
amelogenin, Y-linked
(Previous name: amelogenin (Y chromosome) )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbol: AMGL)
"" "" "" "" "" "" "" "" "" "" "" "" "" "" "" ""Services    
 "" "" "" "" "" "" "" "" "" "" "" "" ""

Aliases &
Descriptions
for AMELY gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
About This Section

  User Feedback
Aliases & Descriptions
amelogenin, Y-linked1 2
AMGL2 3 5
amelogenin (Y chromosome)1 2
AMGY2 3
amelogenin, Y isoform2

External Ids:    HGNC: 4621   Entrez Gene: 2662   Ensembl: ENSG000000997217   UniProtKB: Q992183   

Search outside databases for aliases for AMELY gene

Previous GC identifers: GC0YM006699 GC0YM006436

Summaries
for AMELY gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

  User Feedback		 Entrez Gene summary for AMELY:
This gene encodes a member of the amelogenin family of extracellular matrix proteins. Amelogenins are involved in
biomineralization during tooth enamel development. Mutations in a related gene on chromosome X cause X-linked
amelogenesis imperfecta. (provided by RefSeq)

UniProtKB/Swiss-Prot: AMELY_HUMAN, Q99218
Function: Plays a role in biomineralization. Seems to regulate the formation of crystallites during the secretory stage
of tooth enamel development. Thought to play a major role in the structural organization and mineralization of
developing enamel

Genomic Views
for AMELY gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC and Ensembl (release 56), Regulatory elements and Epigenetics data according to SABiosciences)
About This Section

  User Feedback		 Regulatory elements:
"" SABiosciences Regulatory transcription factor binding sites in the AMELY gene upstream (promoter) region "":
POU2F1   Pax-6   FOXO4   GATA-1   GATA-3   GATA-2   E47   FOXL1   CHOP-10   C/EBPalpha   

Epigenetics:
"" Search SABiosciences Methyl-Profiler DNA Methylation qPCR Primer Assays for AMELY ""

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: Yp11.2   Ensembl cytogenetic band:  Yp11.2   HGNC cytogenetic band: Yp11.2

AMELY Gene in genomic location: bands according to Ensembl, locations according to "" (and/or Entrez Gene and/or Ensembl if different)
""

GeneLoc gene densities for chromosome Y         GeneLoc Exon Structure

GeneLoc location for GC0YM006777:  view genomic region     (about GC identifiers)

Start:
 6,733,959 bp from pter
End:
 6,742,068 bp from pter
Size:
 8,110 bases
Orientation:
 minus strand
RefSeq DNA sequence:
NC_000024.9  NT_011896.9  

Proteins
for AMELY gene

(According to 1UniProtKB, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene, Novus Biologicals, and/or Sino Biological,
Biochemical Assays by Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 May 2010 and Entrez Gene, Antibodies by Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abnova, OriGene, Novus Biologicals, and/or Epitomics)
About This Section

  User Feedback		 UniProtKB/Swiss-Prot: AMELY_HUMAN, Q99218 (See protein sequence)
Recommended Name: Amelogenin, Y isoform precursor  
Size: 206 amino acids; 23250 Da
Subcellular location: Secreted, extracellular space, extracellular matrix
Developmental stage: Transiently but abundantly expressed by ameloblasts during tooth development. Amelogenin is the
predominant protein in developing dental enamel
Miscellaneous: This isoform is encoded on the Y chromosome
Secondary accessions: Q6RWT1
Alternative splicing: 2 isoforms:  Q99218-2   Q99218-1   

REFSEQ proteins: NP_001134.1  

ENSEMBL proteins: 
ENSP00000372506 ENSP00000372505 ENSP00000215479 


Human Recombinant Proteins 
""Browse Purified and Recombinant Proteins at Millipore
""Browse Human Recombinant Proteins at Sigma-Aldrich
"" Browse R&D Systems for human recombinant proteins
""Browse recombinant and purified proteins available from Enzo Life Sciences
""Browse Abnova for HuPro® and/or Recombinant Proteins
""Browse Origene full length recombinant human proteins expressed in human HEK293 cells
""Browse Sino Biological Recombinant Proteins  ""

5 Gene Ontology (GO) cellular component terms (GO ID links to tree view):

GO IDQualified GO termEvidencePubMed IDs
GO:0005576 extracellular region IEA--
GO:0005578 proteinaceous extracellular matrix IEA--
GO:0005634 nucleus IDA18029348
GO:0043231 intracellular membrane-bounded organelle IDA18029348
GO:0044420 extracellular matrix part IC1734713
About this table

"" AMELY for ontologies           About GeneDecksing



Antibodies for AMELY: 
""Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
""Browse Antibodies at Sigma-Aldrich
"" Browse R&D Systems for Antibodies
""Browse Abnova for Monoclonal and Polyclonal Antibodies
""Browse Origene Antibodies ""
""Browse antibodies at Epitomics

Assays for AMELY: 
""Browse Kits and Assays available from Millipore
""Browse ELISAs at Sigma-Aldrich
"" Browse R&D Systems for biochemical assays
""Browse Enzo Life Sciences for kits & assays

Protein Domains/
Families
for AMELY gene

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

  User Feedback
"" AMELY for domains           About GeneDecksing

1 InterPro domain/family:
 IPR004116 Amelogenin

Graphical View of Domain Structure for InterPro Entry Q99218

ProtoNet protein and cluster: Q99218

1 Blocks protein family: IPB004116 Amelogenin

UniProtKB/Swiss-Prot: AMELY_HUMAN, Q99218
Similarity: Belongs to the amelogenin family

Gene Function
for AMELY gene

(According to MGI May 08 2010, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Millipore, Abnova, siRNAs from Applied Biosystems, Sigma-Aldrich, Clones from Millipore, Sigma-Aldrich, OriGene, Sino Biological, Ontologies according to Gene Ontology Consortium 01 May 2010 via Entrez Gene.)
About This Section

  User Feedback
Inhib.
RNA:		""Browse for Gene Knock-down Tools from Millipore
""Browse Abnova for Chimera RNAi Products
"" Origene 29mer shRNA kits in GFP-retroviral vector: AMELY
Origene shRNA RFP: AMELY
Origene basic RS shRNA: AMELY

""Applied Biosystems Silencer® siRNAs for AMELY
""Sigma-Aldrich siRNA for AMELY
Sigma-Aldrich shRNA for AMELY
Explore Sigma-Aldrich super-pooled esiRNAs
Clones:""Browse Clones for the Expression of Recombinant Proteins Available from Millipore
""Browse iPSC Reprogramming Factors at Sigma-Aldrich
"" Origene GFP tagged cDNA clones in CMV expression vector: AMELY
Origene Myc/DDK tagged cDNA clones in CMV expression vector: AMELY
Origene untagged cDNA clones in CMV expression vector: AMELY
""Browse Sino Biological Human cDNA Clones  ""

UniProtKB/Swiss-Prot: AMELY_HUMAN, Q99218
Function: Plays a role in biomineralization. Seems to regulate the formation of crystallites during the secretory stage
of tooth enamel development. Thought to play a major role in the structural organization and mineralization of
developing enamel

Genatlas biochemistry entry for AMELY:
amelogenin,extracellular matrix protein of the dental enamel,Y linked

1 Gene Ontology (GO) molecular function term (GO ID links to tree view):

GO IDQualified GO termEvidencePubMed IDs
GO:0030345 structural constituent of tooth enamel IDA1734713
About this table

"" AMELY for ontologies           About GeneDecksing

Pathways & Interactions
for AMELY gene

(Pathways according to Millipore, Cell Signaling Technology, Sigma-Aldrich, Applied Biosystems GeneAssist, KEGG and/or UniProtKB, (map by GeneGo),
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 May 2010 via Entrez Gene).
About This Section

  User Feedback		"" Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for AMELY

2 Gene Ontology (GO) biological process terms (GO ID links to tree view):

GO IDQualified GO termEvidencePubMed IDs
GO:0007275 multicellular organismal development IEA--
GO:0031214 biomineral formation IEA--
About this table

"" AMELY for ontologies           About GeneDecksing


Drugs & Compounds
for AMELY gene

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

  User Feedback
"" AMELY for compounds           About GeneDecksing

"" Browse drugs & compounds from Enzo Life Sciences
""Browse Small Molecules at Sigma-Aldrich

"" Browse Tocris compounds for AMELY
3 ""Novoseek chemical compound relationships for AMELY gene
Compound   Score   Articles   PubMed IDs for Articles with Shared Sentences (# sentences)
amex 3.52 1 15979380 (1)
agarose 1.01 1 11073085 (1)
zinc 0.47 1 16757184 (1)
About this table


Transcripts
for AMELY gene

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 223 Homo sapiens; Apr 2 2010) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Millipore and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene, microRNA from SABiosciences,
Tagged/untagged cDNA clones from OriGene, Primers from OriGene and/or SABiosciences,
Expression Assays from Applied Biosystems)
About This Section

  User Feedback
Inhib.
RNA:		""Browse for Gene Knock-down Tools from Millipore
""Browse Abnova for Chimera RNAi Products
""Applied Biosystems Silencer® siRNAs:  NM_001143  
"" Origene 29mer shRNA kits in GFP-retroviral vector: AMELY
Origene shRNA RFP: AMELY
Origene basic RS shRNA: AMELY

""Sigma-Aldrich siRNA for AMELY
Sigma-Aldrich shRNA for AMELY
Explore Sigma-Aldrich super-pooled esiRNAs

microRNA:""Search SABiosciences for microRNAs that regulate AMELY: ""
Assays:  ""Applied Biosystems TaqMan® Gene Expression Assays:  
NM_001143  


Clones:"" Origene GFP tagged cDNA clones in CMV expression vector: AMELY
Origene Myc/DDK tagged cDNA clones in CMV expression vector: AMELY
Origene untagged cDNA clones in CMV expression vector: AMELY
Primers:"" Origene genome-wide validated SYBR primer pairs: AMELY
""SABiosciences RT2 qPCR Primer Assay for AMELY: PPH07058A ""

REFSEQ mRNAs for AMELY gene: 

NM_001143.1  

Additional cDNA sequence: 

AY487421.1 BC069138.1 BC074976.1 BC074977.1 M86933.1 

1 DOTS entry:

DT.404954 

6 AceView cDNA sequences:

NM_001143 BC074977 BC074976 BC069138 M86933 AY487421 

"" highest scoring ESTs for AMELY:

M86933 BC069138 BC074976 BC074977 BG198114 NM_001143 AY487421 

Unigene Cluster for AMELY:

Amelogenin, Y-linked
Hs.1238
Unigene Representative Sequence: NM_001143


GeneLoc Exon Structure

3 Ensembl transcripts including schematic representations:
ENST00000383037  ENST00000383036  ENST00000215479  

Expression
for AMELY gene

(Experimental results according to 1GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 223 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems, Primers from OriGene and/or SABiosciences )
About This Section

  User Feedback

AMELY expression in normal and diseased human tissues

"" Applied Biosystems TaqMan ® Gene Expression Assays for AMELY

1""  / 2""  / 3""

3 probe-sets matching AMELY gene

Affymetrix
probe-set		 Array  GeneAnnot data GeneNote data GeneTide data
# genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank
32991_f_at2, 3 U95-A 2 1.00 0.72 1.00 1.00 M86933 1.00 1.00 1.00 1
208220_x_at2, 3 U133-A 2 0.73 0.83 -- -- NM_001143 0.60 1.00 0.82 1
208220_x_at2 U133Plus2 2 0.73 0.83 -- -- -- -- -- -- --
About this table

"" AMELY for expression           About GeneDecksing

Data from Genenote  (Publications) and GNF BioGPS
    About these images
About these images

CGAP SAGE TAG: --

SOURCE GeneReport for Unigene cluster: Hs.1238
Primers:"" Origene genome-wide validated SYBR primer pairs: AMELY ""
""SABiosciences RT2 qPCR Primer Assay for AMELY: PPH07058A ""

Orthologs
for AMELY gene

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI May 08 2010, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

  User Feedback
Orthologs for AMELY gene from 1 species
Organism Gene Locus Description Human
Similarity		 NCBI accessions
chimpanzee
(Pan troglodytes)		 AMELY1   -- amelogenin, Y-linked 99.13(n)
97.92(a)		 473886  XM_001145573.1  XP_001145573.1 
About this table        Species with no ortholog for AMELY

ENSEMBL Gene Tree for AMELY

Paralogs
for AMELY gene

(Paralogs according to 1HomoloGene
and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
About This Section

  User Feedback
Paralogs for AMELY gene
AMELX2  

"" AMELY for paralogs           About GeneDecksing


Genomic Variants
for AMELY gene

(SNPs according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Genotyping Reagents from Applied Biosystems)
About This Section

  User Feedback		  --

Disorders & Mutations
for AMELY gene

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, LSDB, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

  User Feedback
"" AMELY for disorders           About GeneDecksing

OMIM: 410000

3 ""Novoseek disease relationships for AMELY gene

Disease   Score   Articles   PubMed IDs for Articles with Shared Sentences (# sentences)
ameloblastoma 4.18 2 15979380 (2)
amelogenesis imperfecta 2.41 1 10218009 (1)
kallmann syndrome 2.30 1 8283649 (1)
About this table

Human Gene Mutation Database: AMELY
Human Genome Epidemiology Navigator: AMELY (1 document)

Medical News
for AMELY gene

(Possibly Related Articles in Doctor's Guide)
About This Section

  User Feedback		   --

Publications
for AMELY gene

(in PubMed. Associations of this gene to articles via 1Novoseek, 2HGNC, 3Entrez Gene, 4UniProtKB/Swiss-Prot, 5UniProtKB/TrEMBL, 6GAD, and/or 7PharmGKB)
About This Section

  User Feedback		10/27 PubMed articles for AMELY gene (see all 27 ):

Search for AMELY gene

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

  User Feedback
 ANDOR
Aliases
Disorders
Free Text  
  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

Genome Databases showing AMELY gene

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

  User Feedback
Entrez Gene: 266 HGNC: 462 AceView: AMELY Ensembl:ENSG00000099721 euGenes: HUgn266
ECgene: AMELY H-InvDB: AMELY

Other Databases showing AMELY gene

(According to HUGE)
About This Section

  User Feedback		   --

Specialized Databases showing AMELY gene

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

  User Feedback		   --

Intellectual Property
for AMELY gene

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from XenneX, Inc.)
About This Section

  User Feedback		Patent Information for AMELY gene: ""
Search GeneIP for patents involving AMELY

GeneCards and IP: ""
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search


Services
for AMELY gene

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Novus Biologicals,
Epitomics, Sigma-Aldrich, R&D Systems, SABiosciences, Millipore, Abnova,
Clones available from OriGene, Sigma-Aldrich, Sino Biological, Drugs and/or compounds by Sigma-Aldrich, Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

  User Feedback		""
""
Products for AMELY:
"" TaqMan ® Gene Expression Assays
"" TaqMan ® Genotyping Assays
 "" Free SNP selection tool

""
"" Millipore Custom Antibody & Bulk Services
"" Millipore Preclinical / Clinical Development Services
"" Millipore Immunoassay Services
"" Millipore Target Screening & Profiling Services

""
"" Predesigned and custom siRNAs for AMELY"" Browse antibodies at Sigma-Aldrich
"" Explore super-pooled esiRNAs"" Browse proteins at Sigma-Aldrich
"" Lentivirus-delivered shRNAs for AMELY"" Browse small molecules at Sigma-Aldrich
"" "Your Favorite Gene" Pathways"" Browse ELISAs at Sigma-Aldrich
"" Browse iPSC Reprogramming Factors at Sigma-Aldrichfeedback


 ""  ""
"" Antibodies  "" Primer Pairs  
"" Cell Culture Products  "" ELISAs  
"" Flow Cytometry Kits  "" Protease Activity Assays & Reagents  
"" Cell Selection/Detection Kits & Reagents  "" ELISA/Assay Development Kits & Reagents  
"" Multiplex/Array Assay Kits & Reagents  "" ELISpot Kits & Development Modules  
"" Recombinant & Natural Proteins  

"" Search for Recombinant Proteins
"" Search for Antibodies
"" Search for Chimera RNAi
"" Custom Service for Mouse Mab
"" Custom Service for Rabbit Pab from Full-length Protein


""""""""
"" Search for Antibodies & Assays

"" Tagged/untagged cDNA clones
"" Validated SYBR primer pairs
"" Purified proteins from HEK293T cells
"" Western blot validated antibodies
"" shRNA in GFP-retroviral vector
"" Custom immunoassay development
"" Search Tocris compounds for AMELY
"" Regulatory tfbs in AMELY upstream (promoter) region
"" Search Chromatin IP Primers for AMELY
"" Search DNA Methylation qPCR Primer Assays for AMELY
"" RT2 qPCR Primer Assay for AMELY
"" Search GNC Networks for AMELY
"" Search for microRNAs that regulate AMELY
""""""""
"" Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
"" Novus Biologicals
"" Novus Tissue Slides
"" Browse antibodies at Epitomics
"" Browse Sino Biological Proteins and Antibodies
"" Browse Sino Biological cDNA Clones
"" Antibodies/Proteins Production Services
"" Rabbit Monoclonal Antibody Platform
"" Bulk Purchasing
  User Feedback        

GeneCards Homepage - Last full update: 21 May 2010 - Incremental updates: 24 May 2010 , 20 Jun 2010

View Random Gene

Category
acyl-CoA synthetase family member 3
GIFtS Group
The GeneCards human gene database gene index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Copyright © 1996-2010 , Weizmann Institute of Science. All Rights Reserved.
AMELY gene at Home site.
hostname: server5.xennexinc.com db build: 72 index build: 72d solr: 1.4