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AMELX Gene

protein-coding   GIFtS: 53
GCID: GC0XP011221

Amelogenin, X-Linked

(Previous names: amelogenin (X chromosome, amelogenesis imperfecta 1))
(Previous symbols: AMG, AIH1)
  See AMELX-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Amelogenin, X-Linked1 2     AI1E2 5
AMG1 2 3 5     ALGN2
AIH11 2 5     AMGL2
AMGX2 3 5     Amelogenin (Amelogenesis Imperfecta 1, X-Linked)2
Amelogenin (X Chromosome, Amelogenesis Imperfecta 1)1 2     Amelogenin, X Isoform2
Amelogenesis Imperfecta 11 2     

External Ids:    HGNC: 4611   Entrez Gene: 2652   Ensembl: ENSG000001253637   OMIM: 3003915   UniProtKB: Q992173   

Export aliases for AMELX gene to outside databases

Previous GC identifers: GC0XP010290 GC0XP010077 GC0XP010607 GC0XP010672 GC0XP011071 GC0XP009091


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for AMELX Gene:
This gene encodes a member of the amelogenin family of extracellular matrix proteins. Amelogenins are involved in
biomineralization during tooth enamel development. Mutations in this gene cause X-linked amelogenesis imperfecta.
Alternative splicing results in multiple transcript variants encoding different isoforms. (provided by RefSeq,
Jul 2008)

GeneCards Summary for AMELX Gene:
AMELX (amelogenin, X-linked) is a protein-coding gene. Diseases associated with AMELX include root resorption, and amelogenesis imperfecta. GO annotations related to this gene include structural constituent of tooth enamel and identical protein binding. An important paralog of this gene is AMELY.

UniProtKB/Swiss-Prot: AMELX_HUMAN, Q99217
Function: Plays a role in biomineralization. Seems to regulate the formation of crystallites during the secretory
stage of tooth enamel development. Thought to play a major role in the structural organization and mineralization
of developing enamel

Gene Wiki entry for AMELX Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000023.10  NC_018934.2  NT_167197.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the AMELX gene promoter:
         CREB   SRY   deltaCREB   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidAMELX promoter sequence
   Search Chromatin IP Primers for AMELX

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat AMELX


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: Xp22.31-p22.1   Ensembl cytogenetic band:  Xp22.2   HGNC cytogenetic band: Xp22.31-p22.1

AMELX Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
AMELX gene location

GeneLoc information about chromosome X         GeneLoc Exon Structure

GeneLoc location for GC0XP011221:  view genomic region     (about GC identifiers)

Start:
11,311,533 bp from pter      End:
11,318,881 bp from pter
Size:
7,349 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: AMELX_HUMAN, Q99217 (See protein sequence)
Recommended Name: Amelogenin, X isoform precursor  
Size: 191 amino acids; 21603 Da
Developmental stage: Transiently but abundantly expressed by ameloblasts during tooth development. Amelogenin is
the predominant protein in developing dental enamel
Secondary accessions: Q96NW6 Q9UCA7
Alternative splicing: 3 isoforms:  Q99217-1   Q99217-2   Q99217-3   

Explore the universe of human proteins at neXtProt for AMELX: NX_Q99217

REFSEQ proteins (3 alternative transcripts): 
NP_001133.1  NP_872621.1  NP_872622.1  

ENSEMBL proteins: 
 ENSP00000370090   ENSP00000370088   ENSP00000335312  

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Search eBioscience for ELISAs for AMELX 


(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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1 InterPro protein domain:
 IPR004116 Amelogenin

Graphical View of Domain Structure for InterPro Entry Q99217

ProtoNet protein and cluster: Q99217

1 Blocks protein domain: IPB004116 Amelogenin

UniProtKB/Swiss-Prot: AMELX_HUMAN, Q99217
Similarity: Belongs to the amelogenin family


Find genes that share domains with AMELX           About GenesLikeMe


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Molecular Function:

     UniProtKB/Swiss-Prot Summary: AMELX_HUMAN, Q99217
Function: Plays a role in biomineralization. Seems to regulate the formation of crystallites during the secretory
stage of tooth enamel development. Thought to play a major role in the structural organization and mineralization
of developing enamel

     Genatlas biochemistry entry for AMELX:
amelogenin,extracellular matrix protein of the dental enamel,X linked

     Gene Ontology (GO): 5 molecular function terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005515protein binding IPI18434575
GO:0008083growth factor activity ISS1734713
GO:0030345structural constituent of tooth enamel IMP1483698
GO:0042802identical protein binding ISS1734713
GO:0046848hydroxyapatite binding ISS1734713
     
Find genes that share ontologies with AMELX           About GenesLikeMe


Phenotypes:
     3 MGI mutant phenotypes (inferred from 5 alleles(MGI details for Amelx):
 craniofacial  skeleton  tumorigenesis 

Find genes that share phenotypes with AMELX           About GenesLikeMe

Animal Models:
     MGI mouse knock-out Amelxtm1Kul for AMELX

   inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for AMELX
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   genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for AMELX
   genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for AMELX

miRNA
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miRTarBase miRNAs that target AMELX:
hsa-mir-320a (MIRT044727), hsa-mir-148a-3p (MIRT048030)

Block miRNA regulation of human, mouse, rat AMELX using miScript Target Protectors
3 qRT-PCR Assays for microRNAs that regulate AMELX:
hsa-miR-4288 hsa-miR-632 hsa-miR-592
SwitchGear 3'UTR luciferase reporter plasmidAMELX 3' UTR sequence
Inhib. RNA
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Predesigned siRNA for gene silencing in human, mouse, rat AMELX

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DNA2.0 Custom Codon Optimized Gene Synthesis Service for AMELX
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat AMELX

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(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from UniProtKB/Swiss-Prot
AMELX_HUMAN, Q99217: Secreted, extracellular space, extracellular matrix
Subcellular locations from COMPARTMENTS: 

CompartmentConfidence
extracellular5
golgi apparatus2
mitochondrion2
cytoskeleton1
lysosome1
nucleus1

Gene Ontology (GO): 2 cellular component terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005578proteinaceous extracellular matrix IDA2509010
GO:0009986cell surface ISS1734713

Find genes that share ontologies with AMELX           About GenesLikeMe


(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for AMELX
Interactions:

    GeneGlobe Interaction Network for AMELX

STRING Interaction Network Preview (showing 5 interactants - click image to see 15)

Selected Interacting proteins for AMELX (ENSP000003700884) via UniProtKB, MINT, STRING, and/or I2D (see all 15)
InteractantInteraction Details
GeneCardExternal ID(s)
BAG6ENSP000003651314STRING: ENSP00000365131
AHSGENSP000003938874STRING: ENSP00000393887
CD63ENSP000002578574STRING: ENSP00000257857
COL5A3ENSP000002648284STRING: ENSP00000264828
FITM1ENSP000002674264STRING: ENSP00000267426
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Gene Ontology (GO): Selected biological process terms (see all 14):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0001649osteoblast differentiation ISS1734713
GO:0001837epithelial to mesenchymal transition ISS1734713
GO:0002062chondrocyte differentiation ISS1734713
GO:0007155cell adhesion ISS1734713
GO:0007165signal transduction TAS16674683

Find genes that share ontologies with AMELX           About GenesLikeMe



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore
   Browse drugs & compounds from Enzo Life Sciences
  Browse compounds at ApexBio 

Browse Tocris compounds for AMELX



(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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REFSEQ mRNAs for AMELX gene (3 alternative transcripts): 
NM_001142.2  NM_182680.1  NM_182681.1  

Unigene Cluster for AMELX:

Amelogenin, X-linked
Hs.654436
Unigene Representative Sequence: NM_182680
3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000380714(uc004cut.3 uc004cuu.3) ENST00000380712(uc004cus.3)
ENST00000348912
miRNA
Products:
     
Block miRNA regulation of human, mouse, rat AMELX using miScript Target Protectors
3 qRT-PCR Assays for microRNAs that regulate AMELX:
hsa-miR-4288 hsa-miR-632 hsa-miR-592
SwitchGear 3'UTR luciferase reporter plasmidAMELX 3' UTR sequence
Inhib. RNA
Products:
     
OriGene RNAi products in human, mouse, rat for AMELX
Predesigned siRNA for gene silencing in human, mouse, rat AMELX
Clone
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OriGene ORF clones in mouse, rat for AMELX
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
GenScript: all cDNA clones in your preferred vector (see all 3): AMELX (NM_182680)
DNA2.0 Custom Codon Optimized Gene Synthesis Service for AMELX
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat AMELX
Primer
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OriGene qSTAR qPCR primer pairs in human, mouse for AMELX
Pre-validated RT2 qPCR Primer Assay in human, mouse, rat AMELX
  QuantiTect SYBR Green Assays in human, mouse, rat AMELX
  QuantiFast Probe-based Assays in human, mouse, rat AMELX

Additional mRNA sequence: 

AF436849.1 BC069118.1 BC074951.2 M86932.1 S67147.1 

2 DOTS entries:

DT.206426  DT.121305004 

9 AceView cDNA sequences:

AF436849 NM_182680 NM_182681 M86932 NM_001142 S67147 BC074951 BC069118 
BG193202 

GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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AMELX expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: --
AMELX Expression
About this image


AMELX expression in embryonic tissues and stem cells    About this table
Data from LifeMap, the Embryonic Development and Stem Cells Database
 selected tissues (see all 4) fully expand
 
 Tooth (Integumentary System)    fully expand to see all 5 entries
         Early Ameloblasts Dental Enamel
         Dental Enamel
 
 Epithelial Cells
         Early Ameloblasts Dental Enamel
 
 Cartilage (Muscoskeletal System)    fully expand to see all 2 entries
         Intervertebral Disc Nucleus Pulposus Cells Nucleus Pulposus
         Nucleus Pulposus
 
 Primitive Streak (Early Embryonic Tissues)
         Notochord
AMELX Protein expression data from MOPED1, PaxDb2 and MaxQB3 --

SOURCE GeneReport for Unigene cluster: Hs.654436
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QuantiFast Probe-based Assays in human, mouse, rat AMELX
In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for AMELX

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of chordates.

Orthologs for AMELX gene from Selected species (see all 8)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Amelx5 amelogenin X chromosome   --   X (78.95 cM) 169176114 
lizard
(Anolis carolinensis)
Reptilia --
Uncharacterized protein
47(a)
1 → many
GL343702.1(32720-43846)


ENSEMBL Gene Tree for AMELX (if available)
TreeFam Gene Tree for AMELX (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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Paralogs for AMELX gene
AMELY2  
1 SIMAP similar gene for AMELX using alignment to 2 protein entries:     AMELX_HUMAN (see all proteins):
AMELY

Find genes that share paralogs with AMELX           About GenesLikeMe



(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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3 SNPs for AMELX    About this table                                 

Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr X posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
VAR_0375834
Amelogenesis imperfecta 1E (AI1E)4--see VAR_0375832 P T mis40--------
VAR_0375814
Amelogenesis imperfecta 1E (AI1E)4--see VAR_0375812 W S mis40--------
VAR_0375824
Amelogenesis imperfecta 1E (AI1E)4--see VAR_0375822 T I mis40--------

HapMap Linkage Disequilibrium report for AMELX (11311533 - 11318881 bp)

Structural Variations
     Database of Genomic Variants (DGV) 1 variation for AMELX:    About this table    
Variant IDTypeSubtypePubMed ID
esv2739963CNV Deletion23290073

Human Gene Mutation Database (HGMD): AMELX
Locus Specific Mutation Databases (LSDB): AMELX

Site Specific Mutation Identification with PCR Assays
SeqTarget long-range PCR primers for resequencing AMELX
DNA2.0 Custom Variant and Variant Library Synthesis for AMELX

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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OMIM gene information: 300391   
OMIM disorders: 301200  
UniProtKB/Swiss-Prot: AMELX_HUMAN, Q99217
  • Amelogenesis imperfecta 1E (AI1E) [MIM:301200]: A X-linked defect of dental enamel formation. Teeth have
    only a thin layer of enamel with normal hardness. The thinness of the enamel makes the teeth appear small.
    Note=The disease is caused by mutations affecting the gene represented in this entry

  • 8 diseases for AMELX:    
    About MalaCards
    root resorption    amelogenesis imperfecta    amelogenesis imperfecta, type 1e    dental pulp necrosis
    dental fluorosis    nance-horan syndrome    dental caries    amelogenesis imperfecta, type ia5

    5 diseases from the University of Copenhagen DISEASES database for AMELX:
    Amelogenesis imperfecta     Dental fluorosis     Dental pulp necrosis     Root resorption
    Turner syndrome

    Find genes that share disorders with AMELX           About GenesLikeMe

    1 Novoseek inferred disease relationship for AMELX gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    amelogenesis imperfecta 96.8 21 12952177 (2), 7782077 (2), 8081371 (1), 1916828 (1) (see all 17)

    Genetic Association Database (GAD): AMELX
    Human Genome Epidemiology (HuGE) Navigator: AMELX (6 documents)

    Export disorders for AMELX gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for AMELX gene, integrated from 10 sources (see all 85):
    (articles sorted by number of sources associating them with AMELX)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The human enamel protein gene amelogenin is expressed from both the X and the Y chromosomes. (PubMed id 1734713)1, 2, 3, 9 Salido E.C.... Shapiro L.J. (Am. J. Hum. Genet. 1992)
    2. A nomenclature for X-linked amelogenesis imperfecta. (PubMed id 11922868)1, 2, 9 Hart P.S.... Wright J.T. (Arch. Oral Biol. 2002)
    3. Amelogenin signal peptide mutation: correlation between mutations in the amelogenin gene (AMGX) and manifestations of X-linked amelogenesis imperfecta. (PubMed id 7782077)1, 2, 9 Lagerstroem-Fermer M.... Landergren U. (Genomics 1995)
    4. Amelogenin p.M1T and p.W4S mutations underlying hypoplastic X-linked amelogenesis imperfecta. (PubMed id 15111628)1, 2, 9 Kim J.-W.... Hu J.C.-C. (J. Dent. Res. 2004)
    5. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)
    6. Possible association of amelogenin to high caries experience in a Guatemalan-Mayan population. (PubMed id 18042988)1, 4 Deeley K....Vieira A.R. (Caries Res. 2008)
    7. The DNA sequence of the human X chromosome. (PubMed id 15772651)1, 2 Ross M.T.... Bentley D.R. (Nature 2005)
    8. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    9. Production of a monoclonal antibody against human amelogenin. (PubMed id 8118759)1, 2 Catalano-Sherman J.... Deutsch D. (Calcif. Tissue Int. 1994)
    10. Amino acid sequence of a major human amelogenin protein employing Edman degradation and cDNA sequencing. (PubMed id 8254123)1, 2 Catalano-Sherman J.... Deutsch D. (J. Dent. Res. 1993)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 265 HGNC: 461 AceView: AMELX Ensembl:ENSG00000125363 euGenes: HUgn265
    ECgene: AMELX H-InvDB: AMELX

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for AMELX Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for AMELX gene:
    Search GeneIP for patents involving AMELX

    GeneCards and IP:
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    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for AMELX  
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     Block miRNA regulation of human, mouse, rat AMELX using miScript Target Protectors SeqTarget long-range PCR primers for resequencing AMELX
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat AMELX Predesigned siRNA for gene silencing in human, mouse, rat AMELX
     QuantiFast Probe-based Assays in human, mouse, rat AMELX QuantiTect SYBR Green Assays in human, mouse, rat AMELX
     Custom PCR Arrays for AMELX Search Chromatin IP Primers for AMELX
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     Novus Tissue Slides
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     Browse ESI BIO Cell Lines and PureStem Progenitors for AMELX
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     ThermoFisher Antibodies for AMELX
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat AMELX
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for AMELX
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     LSBio Antibodies in human, mouse, rat for AMELX
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     Browse compounds at ApexBio
     Search Addgene for plasmids for AMELX
      Search eBioscience for proteins for AMELX
      Search eBioscience for elisas for AMELX
      eBioscience FlowRNA Probe Sets
           
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