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Aliases for AMD1 Gene

Aliases for AMD1 Gene

  • Adenosylmethionine Decarboxylase 1 2 3
  • S-Adenosylmethionine Decarboxylase 1 2 3
  • EC 4.1.1.50 4 64
  • ADOMETDC 3 4
  • SAMDC 3 4
  • AMD 3 4
  • S-Adenosylmethionine Decarboxylase Proenzyme 3

External Ids for AMD1 Gene

Summaries for AMD1 Gene

Entrez Gene Summary for AMD1 Gene

  • This gene encodes an important intermediate enzyme in polyamine biosynthesis. The polyamines spermine, spermidine, and putrescine are low-molecular-weight aliphatic amines essential for cellular proliferation and tumor promotion. Multiple alternatively spliced transcript variants have been identified. Pseudogenes of this gene are found on chromosomes 5, 6, 10, X and Y. [provided by RefSeq, Dec 2013]

GeneCards Summary for AMD1 Gene

AMD1 (Adenosylmethionine Decarboxylase 1) is a Protein Coding gene. Diseases associated with AMD1 include sleeping sickness and chagas disease. Among its related pathways are Metabolism and Arginine and proline metabolism. GO annotations related to this gene include adenosylmethionine decarboxylase activity.

UniProtKB/Swiss-Prot for AMD1 Gene

  • Essential for biosynthesis of the polyamines spermidine and spermine. Promotes maintenance and self-renewal of embryonic stem cells, by maintaining spermine levels (By similarity).

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for AMD1 Gene

Genomics for AMD1 Gene

Genomic Location for AMD1 Gene

Start:
110,814,621 bp from pter
End:
110,895,713 bp from pter
Size:
81,093 bases
Orientation:
Plus strand

Genomic View for AMD1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for AMD1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for AMD1 Gene

Regulatory Elements for AMD1 Gene

Transcription factor binding sites by QIAGEN in the AMD1 gene promoter:

Proteins for AMD1 Gene

  • Protein details for AMD1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P17707-DCAM_HUMAN
    Recommended name:
    S-adenosylmethionine decarboxylase proenzyme
    Protein Accession:
    P17707
    Secondary Accessions:
    • E1P5F7
    • Q5VXN4
    • Q5VXN6
    • Q9BWK4

    Protein attributes for AMD1 Gene

    Size:
    334 amino acids
    Molecular mass:
    38340 Da
    Cofactor:
    Name=pyruvate; Xref=ChEBI:CHEBI:15361; Note=Binds 1 pyruvoyl group covalently per subunit.;
    Quaternary structure:
    • Heterotetramer of two alpha and two beta chains

    Three dimensional structures from OCA and Proteopedia for AMD1 Gene

    Alternative splice isoforms for AMD1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for AMD1 Gene

Proteomics data for AMD1 Gene at MOPED

Post-translational modifications for AMD1 Gene

  • Is synthesized initially as an inactive proenzyme. Formation of the active enzyme involves a self-maturation process in which the active site pyruvoyl group is generated from an internal serine residue via an autocatalytic post-translational modification. Two non-identical subunits are generated from the proenzyme in this reaction, and the pyruvate is formed at the N-terminus of the alpha chain, which is derived from the carboxyl end of the proenzyme. The post-translation cleavage follows an unusual pathway, termed non-hydrolytic serinolysis, in which the side chain hydroxyl group of the serine supplies its oxygen atom to form the C-terminus of the beta chain, while the remainder of the serine residue undergoes an oxidative deamination to produce ammonia and the pyruvoyl group blocking the N-terminus of the alpha chain
  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys96, Lys291, and Lys301

Other Protein References for AMD1 Gene

Domains for AMD1 Gene

Gene Families for AMD1 Gene

UniProtKB/Swiss-Prot:

DCAM_HUMAN
Family:
  • Belongs to the eukaryotic AdoMetDC family.:
    • P17707
genes like me logo Genes that share domains with AMD1: view

Function for AMD1 Gene

Molecular function for AMD1 Gene

GENATLAS Biochemistry: S-adenosylmethionine decarboxylase 1 (Adomet DC),polyamine biosynthesis
UniProtKB/Swiss-Prot CatalyticActivity: S-adenosyl-L-methionine = S-adenosyl 3-(methylthio)propylamine + CO(2)
UniProtKB/Swiss-Prot EnzymeRegulation: Both proenzyme processing and catalytic activity are stimulated by putrescine. Catalytic activity is inhibited by iodoacetic acid
UniProtKB/Swiss-Prot Function: Essential for biosynthesis of the polyamines spermidine and spermine. Promotes maintenance and self-renewal of embryonic stem cells, by maintaining spermine levels (By similarity).

Enzyme Numbers (IUBMB) for AMD1 Gene

Gene Ontology (GO) - Molecular Function for AMD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004014 adenosylmethionine decarboxylase activity TAS 1917972
genes like me logo Genes that share ontologies with AMD1: view

Phenotypes for AMD1 Gene

MGI mutant phenotypes for AMD1:
inferred from 1 alleles
GenomeRNAi human phenotypes for AMD1:
genes like me logo Genes that share phenotypes with AMD1: view

Animal Models for AMD1 Gene

MGI Knock Outs for AMD1:

miRNA for AMD1 Gene

No data available for Transcription Factor Targeting and HOMER Transcription for AMD1 Gene

Localization for AMD1 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for AMD1 Gene COMPARTMENTS Subcellular localization image for AMD1 gene
Compartment Confidence
cytosol 4
nucleus 3
extracellular 1
peroxisome 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for AMD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with AMD1: view

Pathways for AMD1 Gene

genes like me logo Genes that share pathways with AMD1: view

UniProtKB/Swiss-Prot P17707-DCAM_HUMAN

  • Pathway: Amine and polyamine biosynthesis; S-adenosylmethioninamine biosynthesis; S-adenosylmethioninamine from S-adenosyl-L-methionine: step 1/1

Gene Ontology (GO) - Biological Process for AMD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006557 S-adenosylmethioninamine biosynthetic process IEA --
GO:0006595 polyamine metabolic process TAS --
GO:0006597 spermine biosynthetic process IEA --
GO:0008295 spermidine biosynthetic process IEA --
GO:0034641 cellular nitrogen compound metabolic process TAS --
genes like me logo Genes that share ontologies with AMD1: view

Compounds for AMD1 Gene

(10) HMDB Compounds for AMD1 Gene

Compound Synonyms Cas Number PubMed IDs
1,3-Diaminopropane
  • 1,3-Diamino-n-propane
109-76-2
Carbon dioxide
  • Carbon oxide
124-38-9
N1-Acetylspermine
  • N'-Acetylspermine
25593-72-0
Norspermidine
  • N-(3-aminopropyl)-1,3-Propanediamine
56-18-8
Putrescine
  • 1,4-Butanediamine
110-60-1

(4) Drugbank Compounds for AMD1 Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
5'-{[4-(aminooxy)butyl](methyl)amino}-5'-deoxy-8-ethenyladenosine
target
Putrescine
110-60-1 target
S-Adenosylmethionine
  • Acylcarnitine
29908-03-0 target cofactor
Tris(Hydroxymethyl)Aminomethane
target

(21) Novoseek inferred chemical compound relationships for AMD1 Gene

Compound -log(P) Hits PubMed IDs
sam 486a 96.4 12
s-adenosylmethionine 95.2 116
ethylglyoxal-bis-guanylhydrazone 92.9 5
abeado 92.1 6
methylglyoxal bis(guanylhydrazone) 91.7 18
genes like me logo Genes that share compounds with AMD1: view

Transcripts for AMD1 Gene

Unigene Clusters for AMD1 Gene

Adenosylmethionine decarboxylase 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for AMD1 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b · 8c ^ 9a · 9b · 9c ^ 10a · 10b
SP1: -
SP2: -
SP3: -
SP4:
SP5: - - - - - -
SP6: - - - - -
SP7:

Relevant External Links for AMD1 Gene

GeneLoc Exon Structure for
AMD1
ECgene alternative splicing isoforms for
AMD1

Expression for AMD1 Gene

mRNA expression in normal human tissues for AMD1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for AMD1 Gene

SOURCE GeneReport for Unigene cluster for AMD1 Gene Hs.159118

genes like me logo Genes that share expressions with AMD1: view

Orthologs for AMD1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for AMD1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia AMD1 36
  • 99.9 (n)
  • 100 (a)
AMD1 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia AMD1 36
  • 97.6 (n)
  • 99.1 (a)
AMD1 37
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia AMD1 36
  • 97.21 (n)
  • 98.5 (a)
AMD1 37
  • 96 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Amd1 36
  • 95.91 (n)
  • 98.2 (a)
Amd1 16
Amd1 37
  • 98 (a)
OneToMany
Amd2 37
  • 98 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia AMD1 37
  • 70 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia AMD1 37
  • 91 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Amd1 36
  • 95.18 (n)
  • 97.29 (a)
chicken
(Gallus gallus)
Aves AMD1 36
  • 89.26 (n)
  • 89.16 (a)
AMD1 37
  • 85 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia AMD1 37
  • 85 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia amd1-prov 36
tropical clawed frog
(Silurana tropicalis)
Amphibia amd1 36
  • 83.13 (n)
  • 84.76 (a)
Str.665 36
zebrafish
(Danio rerio)
Actinopterygii amd1 36
  • 78.89 (n)
  • 81.52 (a)
amd1 37
  • 79 (a)
OneToOne
zgc55614 36
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP009619 36
  • 39.13 (n)
  • 29.81 (a)
fruit fly
(Drosophila melanogaster)
Insecta SamDC 36
  • 56.25 (n)
  • 52.19 (a)
SamDC 37
  • 47 (a)
OneToOne
SamDC 38
  • 48 (a)
worm
(Caenorhabditis elegans)
Secernentea smd-1 36
  • 49.54 (n)
  • 43.34 (a)
smd-1 37
  • 37 (a)
OneToOne
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ABL061C 36
  • 45.29 (n)
  • 35.87 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SPE2 36
  • 46.28 (n)
  • 35.17 (a)
SPE2 37
  • 28 (a)
OneToOne
SPE2 39
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0C14410g 36
  • 47.75 (n)
  • 36.5 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT5G15950 36
  • 50.06 (n)
  • 41.57 (a)
rice
(Oryza sativa)
Liliopsida Os09g0424300 36
  • 48.28 (n)
  • 41.91 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU01083 36
  • 49.49 (n)
  • 44.48 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes spe2 36
  • 48.89 (n)
  • 43.17 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.9738 36
sea squirt
(Ciona savignyi)
Ascidiacea CSA.1643 37
  • 46 (a)
OneToOne
Species with no ortholog for AMD1:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for AMD1 Gene

ENSEMBL:
Gene Tree for AMD1 (if available)
TreeFam:
Gene Tree for AMD1 (if available)

Paralogs for AMD1 Gene

Selected SIMAP similar genes for AMD1 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with AMD1: view

No data available for Paralogs for AMD1 Gene

Variants for AMD1 Gene

Sequence variations from dbSNP and Humsavar for AMD1 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type MAF
rs706940 -- 110,874,741(-) TCCCC(C/G/T)CAAAA upstream-variant-2KB, intron-variant
rs781192 -- 110,875,666(+) GTGCC(C/G)GCTTC intron-variant
rs781193 -- 110,874,527(-) TCGAA(C/G/T)GCAGA upstream-variant-2KB, intron-variant
rs781194 -- 110,895,008(-) TATAT(A/T)ACTAG utr-variant-3-prime, nc-transcript-variant
rs802653 -- 110,819,683(+) agtga(C/T)tccat intron-variant

Structural Variations from Database of Genomic Variants (DGV) for AMD1 Gene

Variant ID Type Subtype PubMed ID
nsv886538 CNV Gain 21882294
nsv830773 CNV Loss 17160897
nsv819336 CNV Gain 19587683

Relevant External Links for AMD1 Gene

HapMap Linkage Disequilibrium report
AMD1
Human Gene Mutation Database (HGMD)
AMD1

Disorders for AMD1 Gene

(1) University of Copenhagen DISEASES for AMD1 Gene

(16) Novoseek inferred disease relationships for AMD1 Gene

Disease -log(P) Hits PubMed IDs
pneumocystis carinii infections 50 1
bladder carcinoma 39.7 3
melanoma b16 25.6 1
colon cancer 18.4 6
chagas disease 14.2 1

Relevant External Links for AMD1

Genetic Association Database (GAD)
AMD1
Human Genome Epidemiology (HuGE) Navigator
AMD1
genes like me logo Genes that share disorders with AMD1: view

No data available for UniProtKB/Swiss-Prot for AMD1 Gene

Publications for AMD1 Gene

  1. Amino acid residues necessary for putrescine stimulation of human S- adenosylmethionine decarboxylase proenzyme processing and catalytic activity. (PMID: 1917972) Stanley B.A. … Pegg A.E. (J. Biol. Chem. 1991) 3 4 23
  2. The crystal structure of human S-adenosylmethionine decarboxylase at 2.25-A resolution reveals a novel fold. (PMID: 10378277) Ekstrom J.L. … Ealick S.E. (Structure 1999) 3 4 23
  3. Mechanistic studies of the processing of human S-adenosylmethionine decarboxylase proenzyme. Isolation of an ester intermediate. (PMID: 10574985) Xiong H. … Pegg A.E. (J. Biol. Chem. 1999) 3 4 23
  4. S-adenosylmethionine decarboxylase in human brain. Regional distribution and influence of aging. (PMID: 8353934) Morrison L.D. … Kish S.J. (Brain Res. Dev. Brain Res. 1993) 3 23
  5. The human S-adenosylmethionine decarboxylase gene: nucleotide sequence of a pseudogene and chromosomal localization of the active gene (AMD1) and the pseudogene (AMD2). (PMID: 7789170) Maric S.C. … JAonne O.A. (Cytogenet. Cell Genet. 1995) 3 23

Products for AMD1 Gene

Sources for AMD1 Gene

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