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Aliases for AMD1 Gene

Aliases for AMD1 Gene

  • Adenosylmethionine Decarboxylase 1 2 3
  • S-Adenosylmethionine Decarboxylase 1 2 3
  • EC 4 63
  • ADOMETDC 3 4
  • SAMDC 3 4
  • AMD 3 4

External Ids for AMD1 Gene

Previous GeneCards Identifiers for AMD1 Gene

  • GC06P111031
  • GC06P111218
  • GC06P111241
  • GC06P111304
  • GC06P108767
  • GC06P111195

Summaries for AMD1 Gene

Entrez Gene Summary for AMD1 Gene

  • This gene encodes an important intermediate enzyme in polyamine biosynthesis. The polyamines spermine, spermidine, and putrescine are low-molecular-weight aliphatic amines essential for cellular proliferation and tumor promotion. Multiple alternatively spliced transcript variants have been identified. Pseudogenes of this gene are found on chromosomes 5, 6, 10, X and Y. [provided by RefSeq, Dec 2013]

GeneCards Summary for AMD1 Gene

AMD1 (Adenosylmethionine Decarboxylase 1) is a Protein Coding gene. Diseases associated with AMD1 include sleeping sickness and rh isoimmunization. Among its related pathways are Metabolism and Arginine and proline metabolism. GO annotations related to this gene include adenosylmethionine decarboxylase activity.

UniProtKB/Swiss-Prot for AMD1 Gene

  • Essential for biosynthesis of the polyamines spermidine and spermine. Promotes maintenance and self-renewal of embryonic stem cells, by maintaining spermine levels (By similarity).

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for AMD1 Gene

Genomics for AMD1 Gene

Regulatory Elements for AMD1 Gene

Transcription factor binding sites by QIAGEN in the AMD1 gene promoter:

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for AMD1 Gene

110,814,621 bp from pter
110,895,713 bp from pter
81,093 bases
Plus strand

Genomic View for AMD1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for AMD1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for AMD1 Gene

Proteins for AMD1 Gene

  • Protein details for AMD1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    S-adenosylmethionine decarboxylase proenzyme
    Protein Accession:
    Secondary Accessions:
    • E1P5F7
    • Q5VXN4
    • Q5VXN6
    • Q9BWK4

    Protein attributes for AMD1 Gene

    334 amino acids
    Molecular mass:
    38340 Da
    Name=pyruvate; Xref=ChEBI:CHEBI:15361; Note=Binds 1 pyruvoyl group covalently per subunit.;
    Quaternary structure:
    • Heterotetramer of two alpha and two beta chains

    Three dimensional structures from OCA and Proteopedia for AMD1 Gene

    Alternative splice isoforms for AMD1 Gene


neXtProt entry for AMD1 Gene

Proteomics data for AMD1 Gene at MOPED

Post-translational modifications for AMD1 Gene

  • Is synthesized initially as an inactive proenzyme. Formation of the active enzyme involves a self-maturation process in which the active site pyruvoyl group is generated from an internal serine residue via an autocatalytic post-translational modification. Two non-identical subunits are generated from the proenzyme in this reaction, and the pyruvate is formed at the N-terminus of the alpha chain, which is derived from the carboxyl end of the proenzyme. The post-translation cleavage follows an unusual pathway, termed non-hydrolytic serinolysis, in which the side chain hydroxyl group of the serine supplies its oxygen atom to form the C-terminus of the beta chain, while the remainder of the serine residue undergoes an oxidative deamination to produce ammonia and the pyruvoyl group blocking the N-terminus of the alpha chain
  • Ubiquitination at Lys 96, Lys 291, and Lys 301
  • Modification sites at PhosphoSitePlus

Domains & Families for AMD1 Gene

Gene Families for AMD1 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the eukaryotic AdoMetDC family.
  • Belongs to the eukaryotic AdoMetDC family.
genes like me logo Genes that share domains with AMD1: view

Function for AMD1 Gene

Molecular function for AMD1 Gene

GENATLAS Biochemistry:
S-adenosylmethionine decarboxylase 1 (Adomet DC),polyamine biosynthesis
UniProtKB/Swiss-Prot CatalyticActivity:
S-adenosyl-L-methionine = S-adenosyl 3-(methylthio)propylamine + CO(2)
UniProtKB/Swiss-Prot EnzymeRegulation:
Both proenzyme processing and catalytic activity are stimulated by putrescine. Catalytic activity is inhibited by iodoacetic acid
UniProtKB/Swiss-Prot Function:
Essential for biosynthesis of the polyamines spermidine and spermine. Promotes maintenance and self-renewal of embryonic stem cells, by maintaining spermine levels (By similarity).

Enzyme Numbers (IUBMB) for AMD1 Gene

Gene Ontology (GO) - Molecular Function for AMD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004014 adenosylmethionine decarboxylase activity TAS 1917972
GO:0019810 putrescine binding IBA --
genes like me logo Genes that share ontologies with AMD1: view
genes like me logo Genes that share phenotypes with AMD1: view

Animal Models for AMD1 Gene

MGI Knock Outs for AMD1:

miRNA for AMD1 Gene

miRTarBase miRNAs that target AMD1

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for AMD1

In Situ Assay Products

Flow Cytometry Products

No data available for Transcription Factor Targets and HOMER Transcription for AMD1 Gene

Localization for AMD1 Gene

Subcellular locations from

Jensen Localization Image for AMD1 Gene COMPARTMENTS Subcellular localization image for AMD1 gene
Compartment Confidence
cytosol 4
nucleus 2
extracellular 1
mitochondrion 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for AMD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with AMD1: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for AMD1 Gene

Pathways & Interactions for AMD1 Gene

genes like me logo Genes that share pathways with AMD1: view

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays
    • Amino Acid Metabolism I in human,mouse,rat
    • cAMP / Ca2+ Signaling PathwayFinder in human,mouse,rat

UniProtKB/Swiss-Prot P17707-DCAM_HUMAN

  • Pathway: Amine and polyamine biosynthesis; S-adenosylmethioninamine biosynthesis; S-adenosylmethioninamine from S-adenosyl-L-methionine: step 1/1

Gene Ontology (GO) - Biological Process for AMD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006557 S-adenosylmethioninamine biosynthetic process IEA --
GO:0006595 polyamine metabolic process TAS --
GO:0006597 spermine biosynthetic process IBA --
GO:0008295 spermidine biosynthetic process IBA --
GO:0034641 cellular nitrogen compound metabolic process TAS --
genes like me logo Genes that share ontologies with AMD1: view

No data available for SIGNOR curated interactions for AMD1 Gene

Drugs & Compounds for AMD1 Gene

(14) Drugs for AMD1 Gene - From: NovoSeek, HMDB, and DrugBank

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
S-Adenosylmethionine Approved Nutra Target, cofactor 0
spermine Approved Nutra Channel blocker 0
Pyruvic acid Approved Nutra 0
Nitric Oxide Approved Pharma 540
Ornithine Approved Nutra Full agonist, Agonist 31

(16) Additional Compounds for AMD1 Gene - From: HMDB and NovoSeek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
  • 1,3-Diamino-N-propane
  • 1,3-Propanediamine
  • 1,3-Propylenediamine
  • 1,3-Trimethylenediamine
  • 3-Aminopropylamine
carbon dioxide
  • Carbon oxide
  • Carbon-12 dioxide
  • Carbonic acid anhydride
  • Carbonic acid gas
  • Carbonic anhydride
Hydrogen Ion
  • Hydrogen cation
  • Hydron
  • Proton
  • N'-Acetylspermine
  • N'-Monoacetylspermine
  • N(1)-Acetylspermine
  • N-(3-((4-((3-Aminopropyl)amino)butyl)amino)propyl)-Acetamide
  • N-Acetylspermine
  • -1,3-propanediamine
  • 1,7-Diamino-4-azaheptane
  • 3, 3'-Diaminodipropylamine
  • 3, {3'-Iminobis[propylamine]}
  • 3,3'-Diamino-Dipropylamine
genes like me logo Genes that share compounds with AMD1: view

Transcripts for AMD1 Gene

Unigene Clusters for AMD1 Gene

Adenosylmethionine decarboxylase 1:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for AMD1

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for AMD1 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b · 8c ^ 9a · 9b · 9c ^ 10a · 10b
SP1: -
SP2: -
SP3: -
SP5: - - - - - -
SP6: - - - - -

Relevant External Links for AMD1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for AMD1 Gene

mRNA expression in normal human tissues for AMD1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for AMD1 Gene

This gene is overexpressed in Platelet (40.3) and Placenta (28.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for AMD1 Gene

SOURCE GeneReport for Unigene cluster for AMD1 Gene Hs.159118

genes like me logo Genes that share expression patterns with AMD1: view

Protein tissue co-expression partners for AMD1 Gene

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for AMD1 Gene

Orthologs for AMD1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for AMD1 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia AMD1 35
  • 97.6 (n)
  • 99.1 (a)
AMD1 36
  • 99 (a)
(Canis familiaris)
Mammalia AMD1 35
  • 97.21 (n)
  • 98.5 (a)
AMD1 36
  • 96 (a)
(Mus musculus)
Mammalia Amd1 35
  • 95.91 (n)
  • 98.2 (a)
Amd1 16
Amd1 36
  • 98 (a)
Amd2 36
  • 98 (a)
(Pan troglodytes)
Mammalia AMD1 35
  • 99.9 (n)
  • 100 (a)
AMD1 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Amd1 35
  • 95.18 (n)
  • 97.29 (a)
(Monodelphis domestica)
Mammalia AMD1 36
  • 70 (a)
(Ornithorhynchus anatinus)
Mammalia AMD1 36
  • 91 (a)
(Gallus gallus)
Aves AMD1 35
  • 89.26 (n)
  • 89.16 (a)
AMD1 36
  • 85 (a)
(Anolis carolinensis)
Reptilia AMD1 36
  • 85 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia amd1 35
  • 83.13 (n)
  • 84.76 (a)
Str.665 35
African clawed frog
(Xenopus laevis)
Amphibia amd1-prov 35
(Danio rerio)
Actinopterygii amd1 35
  • 78.89 (n)
  • 81.52 (a)
zgc55614 35
amd1 36
  • 79 (a)
fruit fly
(Drosophila melanogaster)
Insecta SamDC 37
  • 48 (a)
SamDC 35
  • 56.25 (n)
  • 52.19 (a)
SamDC 36
  • 47 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP009619 35
  • 39.13 (n)
  • 29.81 (a)
(Caenorhabditis elegans)
Secernentea smd-1 35
  • 49.54 (n)
  • 43.34 (a)
smd-1 36
  • 37 (a)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ABL061C 35
  • 45.29 (n)
  • 35.87 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0C14410g 35
  • 47.75 (n)
  • 36.5 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SPE2 35
  • 46.28 (n)
  • 35.17 (a)
SPE2 36
  • 28 (a)
SPE2 38
thale cress
(Arabidopsis thaliana)
eudicotyledons AT5G15950 35
  • 50.06 (n)
  • 41.57 (a)
(Oryza sativa)
Liliopsida Os09g0424300 35
  • 48.28 (n)
  • 41.91 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.9738 35
bread mold
(Neurospora crassa)
Ascomycetes NCU01083 35
  • 49.49 (n)
  • 44.48 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes spe2 35
  • 48.89 (n)
  • 43.17 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.1643 36
  • 46 (a)
Species with no ortholog for AMD1:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for AMD1 Gene

Gene Tree for AMD1 (if available)
Gene Tree for AMD1 (if available)

Paralogs for AMD1 Gene

(1) SIMAP similar genes for AMD1 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with AMD1: view

No data available for Paralogs for AMD1 Gene

Variants for AMD1 Gene

Sequence variations from dbSNP and Humsavar for AMD1 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type MAF
rs1279592 -- 110,883,713(-) ttggg(A/T)ggctg intron-variant
rs1279591 -- 110,883,748(-) tgggc(A/G)tggtg intron-variant
rs1279590 -- 110,884,149(-) ctatg(C/T)tattt intron-variant
rs1279589 -- 110,884,202(-) tgttt(C/G)taggt intron-variant
rs1279588 -- 110,829,775(+) tggga(A/G)gttga intron-variant

Structural Variations from Database of Genomic Variants (DGV) for AMD1 Gene

Variant ID Type Subtype PubMed ID
nsv886538 CNV Gain 21882294
nsv830773 CNV Loss 17160897
nsv819336 CNV Gain 19587683

Variation tolerance for AMD1 Gene

Residual Variation Intolerance Score: 27.03% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.66; 14.14% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for AMD1 Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for AMD1 Gene

Disorders for AMD1 Gene

MalaCards: The human disease database

(9) MalaCards diseases for AMD1 Gene - From: DISEASES, NovoSeek, and GeneCards

Disorder Aliases PubMed IDs
sleeping sickness
  • african sleeping sickness
rh isoimmunization
  • rh incompatibility affecting management of mother
bone lymphoma
  • lymphoma of bone
  • dirofilaria infectious disease
- elite association
Search AMD1 in MalaCards View complete list of genes associated with diseases

Relevant External Links for AMD1

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with AMD1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for AMD1 Gene

Publications for AMD1 Gene

  1. Structural basis for the inactivation of AdoMetDC K12R mutant. (PMID: 16515461) Yerlikaya A. … Stanley B.A. (Protein Pept. Lett. 2006) 23 25 67
  2. The activator-binding site of Onchocerca volvulus S-adenosylmethionine decarboxylase, a potential drug target. (PMID: 12974388) Ndjonka D. … LA1ersen K. (Biol. Chem. 2003) 23 25 67
  3. Cinnamic acid-inhibited ribulose-1,5-bisphosphate carboxylase activity is mediated through decreased spermine and changes in the ratio of polyamines in cowpea. (PMID: 19651461) Huang X. … Bie Z. (J. Plant Physiol. 2010) 23 67
  4. Identification of the primary structure and post-translational modification of rat S-adenosylmethionine decarboxylase. (PMID: 20460772) Wada M. … Shirahata A. (Biol. Pharm. Bull. 2010) 23 67
  5. Structural biology of S-adenosylmethionine decarboxylase. (PMID: 19997761) Bale S. … Ealick S.E. (Amino Acids 2010) 23 67

Products for AMD1 Gene

Sources for AMD1 Gene

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