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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

AMD1 Gene

protein-coding   GIFtS: 67
GCID: GC06P111195

adenosylmethionine decarboxylase 1

(Previous name: S-adenosylmethionine decarboxylase 1 )
 Explore 39 diseases affiliated with
AMD1 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for AMD1    

Aliases
for AMD1 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Adenosylmethionine Decarboxylase 11 2     EC 4.1.1.503 8
SAMDC1 2 3     ADOMETDC2
S-Adenosylmethionine Decarboxylase 11 2     S-Adenosylmethionine Decarboxylase Proenzyme2
AMD2 3     AdoMetDC3

External Ids:    HGNC: 4571   Entrez Gene: 2622   Ensembl: ENSG000001235057   OMIM: 1809805   UniProtKB: P177073   

Export aliases for AMD1 gene to outside databases

Previous GC identifers: GC06P111031 GC06P111218 GC06P111241 GC06P111304 GC06P108767


Summaries
for AMD1 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for AMD1:
This gene encodes an important intermediate enzyme in polyamine biosynthesis. The polyamines spermine, spermidine, and
putrescine are low-molecular-weight aliphatic amines essential for cellular proliferation and tumor promotion. Two
alternatively spliced transcript variants that encode different proteins have been identified. Pseudogenes of this
gene are found on chromosomes 5, 6, 10, X and Y.(provided by RefSeq, Jul 2010)




Genomic Views
for AMD1 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000006.11  NC_018917.1  NT_025741.15  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the AMD1 gene promoter:
         SRY   FOXO4   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): AMD1 promoter sequence
   Search SABiosciences Chromatin IP Primers for AMD1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat AMD1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6q21   Ensembl cytogenetic band:  6q21   HGNC cytogenetic band: 6q21

AMD1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
AMD1 gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06P111195:  view genomic region     (about GC identifiers)

Start:
 111,195,973 bp from pter      End:
 111,216,916 bp from pter
Size:
 20,944 bases      Orientation:
 plus strand

Proteins
for AMD1 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: DCAM_HUMAN, P17707 (See protein sequence)
Recommended Name: S-adenosylmethionine decarboxylase proenzyme precursor  
Size: 334 amino acids; 38340 Da
Cofactor: Pyruvoyl group
Subunit: Heterotetramer of two alpha and two beta chains
6/25 PDB 3D structures from and Proteopedia for AMD1 (see all 25):
1I72 (3D)        1I79 (3D)        1I7B (3D)        1I7C (3D)        1I7M (3D)        1JEN (3D)    
Secondary accessions: E1P5F7 Q5VXN4 Q5VXN6 Q9BWK4
Alternative splicing: 2 isoforms:  P17707-1   P17707-2   

Explore the universe of human proteins at neXtProt for AMD1: NX_P17707

Post-translational modifications:

  • Is synthesized initially as an inactive proenzyme. Formation of the active enzyme involves a self-maturation process in
    • which the active site pyruvoyl group is generated from an internal serine residue via an autocatalytic
    post-translational modification. Two non-identical subunits are generated from the proenzyme in this reaction, and the
    pyruvate is formed at the N-terminus of the alpha chain, which is derived from the carboxyl end of the proenzyme. The
    post-translation cleavage follows an unusual pathway, termed non-hydrolytic serinolysis, in which the side chain
    hydroxyl group of the serine supplies its oxygen atom to form the C-terminus of the beta chain, while the remainder of
    the serine residue undergoes an oxidative deamination to produce ammonia and the pyruvoyl group blocking the
    N-terminus of the alpha chain1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P17707

    • 4/14 DME Specific Peptides for AMD1 (P17707) (see all 14)
     PCGYSMN  TIHITPE  YVLSESS  VMDQFYMK 

    AMD1 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (2 alternative transcripts): 
    NP_001028231.1  NP_001625.2  

    ENSEMBL proteins: 
     ENSP00000357880   ENSP00000357877   ENSP00000357870   ENSP00000433396   ENSP00000389988  
     ENSP00000357871  
    Reactome Protein details: P17707
    Human Recombinant Protein Products: 
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    OriGene Purified Protein: AMD1
    OriGene Protein Over-expression Lysate (see all 2): AMD1
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    GenScript Custom Purified and Recombinant Proteins Services for AMD1
    Novus Biologicals AMD1 Proteins
    Novus Biologicals AMD1 Lysates
    Browse Sino Biological Recombinant Proteins
    ProSpec Recombinant Protein for AMD1
    Uscn Proteins for AMD1

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005829cytosol TAS--


    AMD1 for ontologies           About GeneDecksing



    AMD1 Antibody Products: 
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    ThermoFisher Antibodies for AMD1

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    Uscn ELISAs and CLIAs for AMD1

    Protein Domains /
    Families
    for AMD1 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    AMD1 for domains           About GeneDecksing

    4 InterPro domains/families:
     IPR001985 S-AdoMet_decarboxylase
     IPR018166 S-AdoMet_deCO2ase_CS
     IPR016067 S-AdoMet_deCO2ase_core
     IPR018167 S-AdoMet_decarboxylase_subgr

    Graphical View of Domain Structure for InterPro Entry P17707

    ProtoNet protein and cluster: P17707

    1 Blocks protein family: IPB001985 S-adenosylmethionine decarboxylase

    UniProtKB/Swiss-Prot: DCAM_HUMAN, P17707
    Similarity: Belongs to the eukaryotic AdoMetDC family


    Function
    for AMD1 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: DCAM_HUMAN, P17707
    Catalytic activity: S-adenosyl-L-methionine = (5-deoxy-5-adenosyl)(3-aminopropyl)-methylsulfonium salt + CO(2)
    Enzyme regulation: Both proenzyme processing and catalytic activity are stimulated by putrescine. Catalytic activity is
    inhibited by iodoacetic acid

         Genatlas biochemistry entry for AMD1:
    S-adenosylmethionine decarboxylase 1 (Adomet DC),polyamine biosynthesis

    Enzyme Number (IUBMB): EC 4.1.1.501 2

    miRNA
    Products:            		 OriGene 3'-UTR Clone (see all 2): AMD1
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat AMD1
    8/25 QIAGEN miScript miRNA Assays for microRNAs that regulate AMD1 (see all 25):
    hsa-miR-21* hsa-miR-4288 hsa-miR-2110 hsa-miR-513a-5p hsa-miR-450a hsa-miR-632 hsa-miR-374a hsa-miR-132
    SwitchGear 3'UTR luciferase reporter plasmid: AMD1 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for AMD1 (see all 7)
    OriGene shRNA RFP: AMD1
    OriGene siRNA: AMD1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat AMD1

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for AMD1

    Clone
    Products:             		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for AMD1 (see all 4)
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    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector (see all 2): AMD1 (NM_001634)
    Sino Biological Human cDNA Clone for AMD1
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for AMD1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat AMD1 

    Cell Line
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    Search LifeMap BioReagents cell lines for AMD1

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for AMD1

    Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004014adenosylmethionine decarboxylase activity TAS1917972


    AMD1 for ontologies           About GeneDecksing


    1 GenomeRNAi human phenotype for AMD1:
     Increased cilium length after  

    Animal Models:
         Mouse knock-out Amd1tm1Kiga for AMD1
         2 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Amd1):
     embryogenesis  mortality/aging 

    AMD1 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for AMD1 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Metabolism
    		Metabolism1.00
    		Metabolic pathways0.38
    2Metabolism of amino acids and derivatives
    		Metabolism of amino acids and derivatives1.00
    3Arginine and proline metabolism
    		Arginine and proline metabolism1.00
    4Methionine salvage pathway
    		Metabolism of polyamines0.40
    5Sulfur amino acid metabolism
    		Cysteine and methionine metabolism0.36

    Pathway sources
    See GeneCards unified pathways
    Show all pathways


    3        Reactome Pathways for AMD1
        Metabolism of polyamines
    Metabolism
    Metabolism of amino acids and derivatives


    3         Kegg Pathways  (Kegg details for AMD1):
        Cysteine and methionine metabolism
    Arginine and proline metabolism
    Metabolic pathways

    UniProtKB/Swiss-Prot: DCAM_HUMAN, P17707
    Pathway: Amine and polyamine biosynthesis; S-adenosylmethioninamine biosynthesis; S-adenosylmethioninamine from
    S-adenosyl-L-methionine: step 1/1


    AMD1 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for AMD1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 20)

    5/59 Interacting proteins for AMD1 (P177073 ENSP000003578804) via UniProtKB, MINT, STRING, and/or I2D (see all 59)

    InteractantInteraction Details
    GeneCardExternal ID(s)
    HIST1H2BCP628073I2D: score=1 
    HIST1H2BEP628073I2D: score=1 
    HIST1H2BFP628073I2D: score=1 
    HIST1H2BGP628073I2D: score=1 
    HIST1H2BIP628073I2D: score=1 
    About this table

    Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006557S-adenosylmethioninamine biosynthetic process IEA--
    GO:0006595polyamine metabolic process TAS--
    GO:0006597spermine biosynthetic process NAS--
    GO:0008295spermidine biosynthetic process NAS--
    GO:0034641cellular nitrogen compound metabolic process TAS--


    AMD1 for ontologies           About GeneDecksing



    Drugs & Compounds
    for AMD1 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    AMD1 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for AMD1

    10 HMDB Compounds for AMD1    About this table
    CompoundSynonyms CAS #PubMed Ids
    1,3-Diaminopropane1,3-Diamino-n-propane (see all 8)109-76-26798961
    Carbon dioxideCarbon oxide (see all 5)124-38-9--
    N1-AcetylspermineN'-Acetylspermine (see all 6)25593-72-0--
    NorspermidineN-(3-aminopropyl)-1,3-Propanediamine (see all 28)56-18-8--
    Putrescine1,4-Butanediamine (see all 8)110-60-1--
    Pyruvic acid2-Oxopropanoate (see all 14)127-17-3--
    S-Adenosylmethioninamine(5-deoxy-5-adenosyl)(3-aminopropyl) methylsulfonium salt (see all 7)22365-13-5--
    S-Adenosylmethionine(3S)-5'-[(3-amino-3-carboxypropyl)methylsulfonio]-5'-deoxyadenosine (see all 16)29908-03-0--
    Spermidine1,5,10-Triazadecane (see all 15)124-20-9--
    Spermine1,5,10,14-Tetraazatetradecane (see all 18)71-44-3--

    4 DrugBank Compounds for AMD1    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    S-AdenosylmethionineAcylcarnitine (see all 6)29908-03-0targetcofactor16515461 12974388 15051528 12545203
    Putrescine-- 110-60-1target--17139284 17016423
    Tris(Hydroxymethyl)Aminomethane-- --target--17139284 17016423
    5'-{[4-(aminooxy)butyl](methyl)amino}-5'-deoxy-8-ethenyladenosine-- --target--10592235

    10/21 Novoseek chemical compound relationships for AMD1 gene (see all 21)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    sam 486a 96.4 14 9133651 (2), 8877009 (2), 10944598 (1), 16941339 (1) (see all 10)
    s-adenosylmethionine 95.2 156 11032186 (3), 9133651 (2), 12600205 (2), 7789170 (2) (see all 99)
    ethylglyoxal-bis-guanylhydrazone 92.9 12 7958401 (2), 1480164 (1), 9712522 (1), 8352568 (1)
    abeado 92.1 10 9133651 (2), 1637820 (1), 19419862 (1), 1301596 (1) (see all 5)
    methylglyoxal bis(guanylhydrazone) 91.7 29 1511437 (3), 1480164 (2), 8340919 (2), 8877009 (2) (see all 12)
    spermidine 91.4 61 9743591 (2), 1358085 (2), 8343127 (2), 15821146 (2) (see all 41)
    putrescine 90.8 51 9880821 (5), 12974388 (4), 16257247 (3), 9743591 (2) (see all 28)
    spermine 90.4 54 2344358 (4), 8395844 (2), 7945201 (2), 16515461 (2) (see all 38)
    ornithine 86.1 43 12686127 (2), 1511437 (2), 8205541 (2), 7656236 (1) (see all 37)
    dfmo 84.2 16 2114097 (3), 7634128 (1), 9743591 (1), 11698350 (1) (see all 11)

    Search CenterWatch for drugs/clinical trials and news about AMD1 / DCAM 

    Transcripts
    for AMD1 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for AMD1 gene (2 alternative transcripts): 
    NM_001033059.1  NM_001634.4  

    Unigene Cluster for AMD1:

    Adenosylmethionine decarboxylase 1
    Hs.159118  [show with all ESTs]
    Unigene Representative Sequence: BX640599
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000368885(uc003puk.1 uc011eaz.1) ENST00000368882(uc003pul.1 uc011eba.1)
    ENST00000368876(uc011eay.1) ENST00000465404 ENST00000451850 ENST00000368877


    miRNA
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    8/25 QIAGEN miScript miRNA Assays for microRNAs that regulate AMD1 (see all 25):
    hsa-miR-21* hsa-miR-4288 hsa-miR-2110 hsa-miR-513a-5p hsa-miR-450a hsa-miR-632 hsa-miR-374a hsa-miR-132
    SwitchGear 3'UTR luciferase reporter plasmid: AMD1 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for AMD1 (see all 7)
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    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat AMD1
    Clone
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    Primer
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      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat AMD1

    Additional cDNA sequence: 

    AJ420527.1 AJ420567.1 AK026205.1 AK130474.1 AK300330.1 AK302761.1 AK304351.1 AK316471.1 
    AL832698.1 BC000171.2 BX640599.1 M21154.1 

    24/26 DOTS entries (see all 26):

    DT.95153293  DT.121356897  DT.100642958  DT.100824372  DT.456244  DT.100657843  DT.101984850  DT.100824365 
    DT.100824366  DT.95308707  DT.121356891  DT.100037909  DT.121357065  DT.121357067  DT.121357095  DT.95153266 
    DT.95153275  DT.95153296  DT.95153299  DT.100740399  DT.121356885  DT.121357073  DT.121357134  DT.75187528 

    24/466 AceView cDNA sequences (see all 466):

    CA391228 BQ215801 AA828258 AA327870 AL543197 BX108055 BM718443 CD359332 
    AW235553 AU125877 AW769775 AL709799 AL533828 AI659729 BU625372 T29486 
    CR604279 CR611524 CN484062 AU135290 BQ000168 AW150544 BF590430 CA449342 

    GeneLoc Exon Structure

    5/7 Alternative Splicing Database (ASD) splice patterns (SP) for AMD1 (see all 7)    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b · 8c ^ 9a · 9b · 9c ^ 10a · 10b
    SP1:                                                                                -                           
    SP2:                                                                                -                           
    SP3:              -                                                                                             
    SP4:                                                                                                            
    SP5:              -     -     -     -     -     -                                                               


    ECgene alternative splicing isoforms for AMD1

    Expression
    for AMD1 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    AMD1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TTGTTGATTG

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    AMD1 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    2 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    LimbHindlimb Ventral MuscleLimb
    Skeletal MuscleMandibular Arch MusclesSkeletal Muscle
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization
    Stem Cell Differentiation: 1 LifeMap Cell 
    NameCategory
    ES04(HES-4) (Embryonic Stem Cell)Early Embryo, Inner Cell Mass

    See AMD1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for AMD1

    SOURCE GeneReport for Unigene cluster: Hs.159118
        SABiosciences Expression via Pathway-Focused PCR Arrays including AMD1: 
              cAMP / Ca2+ Signaling PathwayFinder in human mouse rat
              Amino Acid Metabolism I in human mouse rat

    Primer
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    Orthologs
    for AMD1 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of eukaryotes.

    Orthologs for AMD1 gene from 10/33 species (see all 33)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Amd11 , 5 S-adenosylmethionine decarboxylase 11, 5 95.91(n)1
    98.2(a)1    		   10 (21.85 cM)5
    117021  NM_009665.51  NP_033795.11 
     402874585 
    chicken
    (Gallus gallus)    		 Aves AMD11 adenosylmethionine decarboxylase 1 89.33(n)
    89.43(a)    		   421755  NM_001012569.1  NP_001012587.1 
    lizard
    (Anolis carolinensis)    		 Reptilia AMD16
    		 --
    		 87(a)
    		 1 ↔ 1
    		 1(191999957-192020664)
    African clawed frog
    (Xenopus laevis)    		 Amphibia amd1-prov2 S-Adenosylmethionine decarboxylase 1A 82.97(n)    BC042281.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii zgc556142 similar to S-adenosylmethionine decarboxylase 1 78.79(n)   394055  BC045404.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta SamDC1 , 3 spermidine biosynthesis adenosylmethionine
    decarboxylase3
    S-adenosylmethionine decarboxylase1    		 48(a)3
    56.22(n)1
    52.35(a)1    		   31D93
    343961  NM_057875.41  NP_477223.21 
    worm
    (Caenorhabditis elegans)    		 Secernentea smd-11 Protein SMD-1 49.95(n)
    43.03(a)    		   173269  NM_061047.4  NP_493448.1 
    baker's yeast
    (Saccharomyces cerevisiae)    		 Saccharomycetes SPE2(YOL052C)4
    SPE21    		 S-adenosylmethionine decarboxylase, required for the more4
    Spe2p1    		 46.38(n)1
    35.17(a)1    		   15(233636-232446)4
    8541051, 4  NP_014590.11, 4 
    thale cress
    (Arabidopsis thaliana)    		 eudicotyledons AT3G255701 S-adenosylmethionine decarboxylase 47.55(n)
    39.86(a)    		   822144  NM_001203043.1  NP_001189972.1 
    rice
    (Oryza sativa)    		 Liliopsida Os09g04243001 hypothetical protein 48.93(n)
    43.02(a)    		   4347103  NM_001069752.1  NP_001063217.1 


    ENSEMBL Gene Tree for AMD1 (if available)
    TreeFam Gene Tree for AMD1 (if available) 

    Paralogs
    for AMD1 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for AMD1 gene
    1 SIMAP similar gene for AMD1 using alignment to 5 protein entries:     DCAM_HUMAN (see all proteins):
    DKFZp686G18136

    AMD1 for paralogs           About GeneDecksing


    5/7 Pseudogenes.org Pseudogenes for AMD1 (see all 7)
    PGOHUM00000238685 PGOHUM00000234322 PGOHUM00000235215 PGOHUM00000243064 PGOHUM00000243286


    Genomic Variants
    for AMD1 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/429 NCBI SNPs in AMD1 are shown (see all 429)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 6 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs122055011,2
    		C,--111194307(+) ggtgcG/Cgtggc 2 -- us2k11Minor allele frequency- C:0.50NA 2
    rs26653591,2
    		C,A,H,--111194468(-) TGCCTC/TAGCCT 2 -- us2k17Minor allele frequency- T:0.08NA WA CSA 13
    rs1869813901,2
    		--111194659(+) CGTTCC/TTGTAA 2 -- us2k10--------
    rs27967491,2
    		C,F,A,H,--111194703(+) AAACCG/CAAACC 2 -- us2k115Minor allele frequency- C:0.34NS EA NA WA CSA 791
    rs1171437261,2
    		F,--111194737(+) ATGTTG/AACATC 2 -- us2k11Minor allele frequency- A:0.03EA 120
    rs126638171,2
    		C,H--111194777(+) TCTAAG/AGATGA 2 -- us2k15Minor allele frequency- A:0.00NS EA NA 422
    rs38405291,2
    		C,--111194934(-) TAAGT-/TAAGT 
                ATAAA     		2 -- us2k1 tfbs30--------
    rs9578241,2
    		C,F,A,H,--111195049(+) GAAGAT/CAGCAC 2 -- us2k113Minor allele frequency- C:0.12NS EA NA 1560
    rs747002271,2
    		--111195174(+) GAAGTA/CGTTTT 2 -- us2k10--------
    rs1118713431,2
    		C,--111195297(+) GGGTAG/AAGCCG 2 -- us2k11Minor allele frequency- A:0.50NA 2

    HapMap Linkage Disequilibrium report for AMD1 (111195973 - 111216916 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 1 variation for AMD1
         1 Indel: 59286

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    Disorders / Diseases
    for AMD1 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    AMD1 for disorders           About GeneDecksing

    OMIM gene information: 180980    OMIM disorders: --

    20/39 diseases for AMD1 (see all 39):    About MalaCards
    age related macular degeneration    dna topoisomerase ii    non-small cell lung carcinoma    familial adenomatous polyposis
    transient cerebral ischemia    spina bifida    macular degeneration    sleeping sickness
    hypochondriasis    chagas disease    bladder carcinoma    ischemia
    constipation    polyposis    colon cancer    trypanosomiasis
    lung carcinoma    colorectal cancer    leishmaniasis    colon adenocarcinoma

    1 disease from the University of Copenhagen DISEASES database for AMD1:
    Sleeping sickness

    10/16 Novoseek disease relationships for AMD1 gene (see all 16)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    pneumocystis carinii infections 50 1 8340919 (1)
    bladder carcinoma 39.7 3 8340919 (1), 8421290 (1), 8205541 (1)
    melanoma b16 25.6 1 8205541 (1)
    colon cancer 18.4 7 11163334 (3), 9880821 (3)
    chagas disease 14.2 1 9677309 (1)
    cancer 8.54 7 17676832 (1), 11016654 (1), 15704548 (1), 10713131 (1) (see all 6)
    ischemia 0 2 1499693 (1)
    cancer lung 0 3 17558447 (1)
    breast cancer 0 4 8877009 (2), 7656236 (1), 15547724 (1)
    metastasis 0 2 11787064 (2)

    Human Genome Epidemiology (HuGE) Navigator: AMD1 (4 documents)

    Export disorders for AMD1 gene to outside databases

    Publications
    for AMD1 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for AMD1 gene, integrated from 9 sources (see all 163):
    (articles sorted by number of sources associating them with AMD1)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. The crystal structure of human S-adenosylmethionine decarboxylase at 2.25-A resolution reveals a novel fold. (PubMed id 10378277)1, 2, 9 Ekstrom J.L.... Ealick S.E. (1999)
    2. Mechanistic studies of the processing of human S-adenosylmethionine decarboxylase proenzyme. Isolation of an ester intermediate. (PubMed id 10574985)1, 2, 9 Xiong H. and Pegg A.E. (1999)
    3. Amino acid residues necessary for putrescine stimulation of human S- adenosylmethionine decarboxylase proenzyme processing and catalytic activity. (PubMed id 1917972)1, 2, 9 Stanley B.A. and Pegg A.E. (1991)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    5. The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)1, 2 Mungall A.J.... Beck S. (2003)
    6. The structural basis for substrate specificity and inhibition of human S-adenosylmethionine decarboxylase. (PubMed id 11583147)1, 2 Tolbert W.D.... Ealick S.E. (2001)
    7. Role of cysteine-82 in the catalytic mechanism of human S- adenosylmethionine decarboxylase. (PubMed id 10029540)1, 2 Xiong H.... Pegg A.E. (1999)
    8. Structure and regulation of mammalian S-adenosylmethionine decarboxylase. (PubMed id 2460457)1, 2 Pajunen A.... Pegg A.E. (1988)
    9. Localization of S-adenosylmethionine decarboxylase in murine tissues by immunohistochemistry. (PubMed id 7634128)1, 9 Gritli-Linde A....Linde A. (1995)
    10. The human S-adenosylmethionine decarboxylase gene: nucleotide sequence of a pseudogene and chromosomal localization of the active gene (AMD1) and the pseudogene (AMD2). (PubMed id 7789170)1, 9 Maric S.C....Janne O.A. (1995)

    External Searches for AMD1 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing AMD1 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 262 HGNC: 457 AceView: AMD1 Ensembl:ENSG00000123505 euGenes: HUgn262
    ECgene: AMD1 Kegg: 262 H-InvDB: AMD1

    Other Databases showing AMD1 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing AMD1 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for AMD1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for AMD1 Genetics and Cytogenetics in Oncology and Haematology

    Intellectual Property
    for AMD1 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for AMD1 gene:
    Search GeneIP for patents involving AMD1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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