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AMBRA1 Gene

protein-coding   GIFtS: 50
GCID: GC11M046417

Autophagy/Beclin-1 Regulator 1

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Autophagy/Beclin-1 Regulator 11 2     DCAF32
DDB1 And CUL4 Associated Factor 31 2     WDR942
WD Repeat Domain 941 2     Activating Molecule In Beclin-1-Regulated Autophagy2
KIAA17363 5     Activating Molecule In BECN1-Regulated Autophagy Protein 12

External Ids:    HGNC: 259901   Entrez Gene: 556262   Ensembl: ENSG000001104977   OMIM: 6113595   UniProtKB: Q9C0C73   

Export aliases for AMBRA1 gene to outside databases

Previous GC identifers: GC11M046375 GC11M046124


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for AMBRA1 Gene:
AMBRA1 (autophagy/beclin-1 regulator 1) is a protein-coding gene.

UniProtKB/Swiss-Prot: AMRA1_HUMAN, Q9C0C7
Function: Regulates autophagy and development of the nervous system. Involved in autophagy in controlling protein
turnover during neuronal development, and in regulating normal cell survival and proliferation (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000011.9  NT_009237.19  NC_018922.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the AMBRA1 gene promoter:
         Pax-5   POU6F1 (c2)   C/EBPalpha   PPAR-gamma1   SRY   S8   HFH-1   PPAR-gamma2   LyF-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidAMBRA1 promoter sequence
   Search Chromatin IP Primers for AMBRA1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat AMBRA1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11p11.2   Ensembl cytogenetic band:  11p11.2   HGNC cytogenetic band: 11p11.2

AMBRA1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
AMBRA1 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11M046417:  view genomic region     (about GC identifiers)

Start:
46,417,964 bp from pter      End:
46,615,675 bp from pter
Size:
197,712 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: AMRA1_HUMAN, Q9C0C7 (See protein sequence)
Recommended Name: Activating molecule in BECN1-regulated autophagy protein 1  
Size: 1298 amino acids; 142507 Da
Subunit: Interacts with BECN1. Probably forms a complex with BECN1 and PIK3C3 (By similarity). Interacts with
BECN1P1/BECN2
Sequence caution: Sequence=BAA91067.1; Type=Frameshift; Positions=682; Sequence=BAB14457.1; Type=Erroneous
initiation; Sequence=BAB21827.1; Type=Erroneous initiation;
Secondary accessions: A6XN33 D3DQP8 G3V193 Q86XD6 Q9H8Z0 Q9NXE7
Alternative splicing: 6 isoforms:  Q9C0C7-1   Q9C0C7-2   Q9C0C7-3   Q9C0C7-4   Q9C0C7-5   Q9C0C7-6   (No experimental confirmation available. Ref.4 (AL834190) sequence differs from that shown due to a frameshift in position 745)

Explore the universe of human proteins at neXtProt for AMBRA1: NX_Q9C0C7

Explore proteomics data for AMBRA1 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys175
  • Modification sites at PhosphoSitePlus

  • See AMBRA1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001254711.1  NP_001254712.1  NP_060219.2  

    ENSEMBL proteins: 
     ENSP00000318313   ENSP00000433372   ENSP00000431926   ENSP00000415327   ENSP00000434895  
     ENSP00000433945   ENSP00000431486   ENSP00000410899   ENSP00000298834  

    AMBRA1 Human Recombinant Protein Products:

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    Cloud-Clone Corp. Proteins for AMBRA1

     
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    Cloud-Clone Corp. ELISAs for AMBRA1
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    Search eBioscience for ELISAs for AMBRA1 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    DCAF: DDB1 and CUL4 associated factors
    WDR: WD repeat domain containing

    4 InterPro protein domains:
     IPR019775 WD40_repeat_CS
     IPR001680 WD40_repeat
     IPR017986 WD40_repeat_dom
     IPR015943 WD40/YVTN_repeat-like_dom

    Graphical View of Domain Structure for InterPro Entry Q9C0C7

    ProtoNet protein and cluster: Q9C0C7

    UniProtKB/Swiss-Prot: AMRA1_HUMAN, Q9C0C7
    Similarity: Contains 3 WD repeats


    Find genes that share domains with AMBRA1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: AMRA1_HUMAN, Q9C0C7
    Function: Regulates autophagy and development of the nervous system. Involved in autophagy in controlling protein
    turnover during neuronal development, and in regulating normal cell survival and proliferation (By similarity)

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI--
         
    Find genes that share ontologies with AMBRA1           About GenesLikeMe


    Phenotypes:
         4 MGI mutant phenotypes (inferred from 1 allele(MGI details for Ambra1):
     cellular  embryogenesis  mortality/aging  nervous system 

    Find genes that share phenotypes with AMBRA1           About GenesLikeMe

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for AMBRA1
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    miRNA
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    miRTarBase miRNAs that target AMBRA1:
    hsa-mir-331-3p (MIRT043533), hsa-mir-186-5p (MIRT045188), hsa-mir-339-5p (MIRT042802)

    Block miRNA regulation of human, mouse, rat AMBRA1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate AMBRA1 (see all 37):
    hsa-miR-642a hsa-miR-4254 hsa-miR-3194-5p hsa-miR-631 hsa-miR-429 hsa-miR-1224-3p hsa-miR-1260b hsa-miR-9
    SwitchGear 3'UTR luciferase reporter plasmidAMBRA1 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for AMBRA1
    Predesigned siRNA for gene silencing in human, mouse, rat AMBRA1

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    GenScript: all cDNA clones in your preferred vector: AMBRA1 (NM_017749)
    Browse Sino Biological Human cDNA Clones
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for AMBRA1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    AMRA1_HUMAN, Q9C0C7: Cytoplasmic vesicle, autophagosome (By similarity). Note=Localizes also to discrete punctae
    along the ciliary axoneme (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus2
    vacuole2
    cytosol1
    endoplasmic reticulum1

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IDA17589504
    GO:0005776autophagic vacuole IEA--
    GO:0005930axoneme ISS--
    GO:0031410cytoplasmic vesicle IEA--

    Find genes that share ontologies with AMBRA1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for AMBRA1 About    
    See pathways by source

    SuperPathContained pathways About
    1Senescence and Autophagy
    Senescence and Autophagy
    2Neuroscience
    Neuroscience


    Find genes that share SuperPaths with AMBRA1           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Cell Signaling Technology (CST) Pathway for AMBRA1
        Neuroscience

    1 BioSystems Pathway for AMBRA1
        Senescence and Autophagy


        Pathway & Disease-focused RT2 Profiler PCR Array including AMBRA1: 
              Autophagy in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for AMBRA1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for AMBRA1 (Q9C0C71, 2, 3 ENSP000003183134) via UniProtKB, MINT, STRING, and/or I2D (see all 238)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    BCL2P104151, 2, 3, ENSP000003296234EBI-2512975,EBI-77694 MINT-8182706 MINT-8182670 MINT-8182688 MINT-8182559 MINT-8182625 MINT-8174974 MINT-8182589 MINT-8182650 MINT-8182607 MINT-8182574 I2D: score=1 STRING: ENSP00000329623
    ENSG00000212866P081073I2D: score=1 
    ENSG00000215328P081073I2D: score=1 
    ENSG00000224501P081073I2D: score=1 
    ENSG00000231555P081073I2D: score=1 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006914autophagy IEA--
    GO:0008285negative regulation of cell proliferation IEA--
    GO:0009790embryo development ----
    GO:0021915neural tube development IEA--
    GO:0030154cell differentiation IEA--

    Find genes that share ontologies with AMBRA1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for AMBRA1 (AMRA1)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for AMBRA1 gene (3 alternative transcripts): 
    NM_001267782.1  NM_001267783.1  NM_017749.3  

    Unigene Cluster for AMBRA1:

    Autophagy/beclin-1 regulator 1
    Hs.654644  [show with all ESTs]
    Unigene Representative Sequence: AK302808
    14 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000314845(uc010rgt.1 uc001ncu.1) ENST00000533727(uc001ncv.2 uc001ncw.2)
    ENST00000534300(uc001ncx.2) ENST00000458649(uc010rgu.1) ENST00000526545
    ENST00000528950 ENST00000529553 ENST00000529963 ENST00000529558 ENST00000531542
    ENST00000524783 ENST00000526606 ENST00000426438(uc009ylc.1) ENST00000298834

    miRNA
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    Block miRNA regulation of human, mouse, rat AMBRA1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate AMBRA1 (see all 37):
    hsa-miR-642a hsa-miR-4254 hsa-miR-3194-5p hsa-miR-631 hsa-miR-429 hsa-miR-1224-3p hsa-miR-1260b hsa-miR-9
    SwitchGear 3'UTR luciferase reporter plasmidAMBRA1 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat AMBRA1
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    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: AMBRA1 (NM_017749)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat AMBRA1
    Primer
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    OriGene qPCR primer pairs and template standards for AMBRA1
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat AMBRA1
      QuantiTect SYBR Green Assays in human, mouse, rat AMBRA1
      QuantiFast Probe-based Assays in human, mouse, rat AMBRA1

    Additional mRNA sequence: 

    AB051523.1 AK000301.1 AK023197.1 AK057896.1 AK302808.1 AK304530.1 AL137611.1 AL834190.1 
    BC045609.1 DQ870924.1 

    13 DOTS entries:

    DT.100779368  DT.95338415  DT.107951  DT.95165030  DT.100779367  DT.102841099  DT.75108941  DT.120731309 
    DT.120731310  DT.91890877  DT.100829056  DT.120731304  DT.40221669 

    Selected AceView cDNA sequences (see all 110):

    AI791940 BU737623 CB149054 BX281628 AK023197 CB216101 AU131702 BU159882 
    CA306509 AB051523 BP353292 BF589843 CR590663 AU159538 AI359466 BU171968 
    BM904226 NM_017749 AL137611 BP352652 AI699895 BM472696 AL834190 BC045609 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for AMBRA1 (see all 6)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19a · 19b ^ 20 ^ 21 ^
    SP1:                                                                                            -                 -                                             
    SP2:                    -                                                           -           -                 -                                             
    SP3:                    -                                                                 -     -                 -                                             
    SP4:                                                                                                                                                            
    SP5:                                                                                                                                                  -         

    ExUns: 22a · 22b
    SP1:            
    SP2:            
    SP3:            
    SP4:            
    SP5:            


    ECgene alternative splicing isoforms for AMBRA1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    AMBRA1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CCCCTCAAAA
    AMBRA1 Expression
    About this image

    AMBRA1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    AMBRA1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.654644
        Pathway & Disease-focused RT2 Profiler PCR Array including AMBRA1: 
              Autophagy in human mouse rat

    Primer
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    OriGene qPCR primer pairs and template standards for AMBRA1
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat AMBRA1
    QuantiTect SYBR Green Assays in human, mouse, rat AMBRA1
    QuantiFast Probe-based Assays in human, mouse, rat AMBRA1
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for AMBRA1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for AMBRA1 gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ambra11 , 5 autophagy/beclin 1 regulator 11, 5 91.45(n)1
    95.55(a)1
      2 (50.63 cM)5
    2283611  NM_172669.31  NP_766257.31 
     917301345 
    chicken
    (Gallus gallus)
    Aves AMBRA11 autophagy/beclin-1 regulator 1 79.49(n)
    85.87(a)
      423194  XM_004941602.1  XP_004941659.1 
    lizard
    (Anolis carolinensis)
    Reptilia AMBRA16
    autophagy/beclin-1 regulator 1
    76(a)
    1 ↔ 1
    1(42796646-42974971)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.145122 Xenopus laevis transcribed sequences 81.52(n)    BX853367.1 
    zebrafish
    (Danio rerio)
    Actinopterygii ambra11 autophagy/beclin-1 regulator 1 59.71(n)
    58.92(a)
      100332642  XM_002667669.3  XP_002667715.3 


    ENSEMBL Gene Tree for AMBRA1 (if available)
    TreeFam Gene Tree for AMBRA1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for AMBRA1 (see all 3140)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1810279951,2
    C--46324255(+) GGTCTC/TGATCT 2 -- us2k10--------
    rs780109291,2
    C--46324260(+) CGATCC/TTCTGA 2 -- us2k10--------
    rs105464761,2
    C--46365593(+) ttatt-/TAtatat 3 -- int10--------
    rs1112986011,2
    F--46417463(+) CTTTCG/AGCCAC 3 -- int11Minor allele frequency- A:0.50CSA 2
    rs801388291,2
    C,F--46417616(+) CTGGCC/TAGTTA 3 -- int11Minor allele frequency- T:0.02NA 120
    rs729100961,2
    C,F--46417651(+) GGTGGG/AAAGCT 3 -- int11Minor allele frequency- A:0.02NA 120
    rs1472449951,2
    C--46417679(+) TCTGTC/TGTTCC 3 -- int10--------
    rs1487550281,2
    --46417813(+) CTCTGA/GCGAAG 3 -- int10--------
    rs14666351,2
    C,F,H--46417815(-) CCCTTC/TGCCAG 3 -- int116Minor allele frequency- T:0.09EA NA NS 1568
    rs1423056071,2
    --46417841(+) TGCACA/CCCACT 3 -- int10--------

    HapMap Linkage Disequilibrium report for AMBRA1 (46417964 - 46615675 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for AMBRA1:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2658413CNV Deletion23128226
    nsv309CNV Loss18451855
    nsv825867CNV Gain20364138
    nsv897321CNV Gain21882294

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 611359    OMIM disorders: --


    Find genes that share disorders with AMBRA1           About GenesLikeMe


    Export disorders for AMBRA1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for AMBRA1 gene, integrated from 10 sources (see all 45):
    (articles sorted by number of sources associating them with AMBRA1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Ambra1 regulates autophagy and development of the nervous system. (PubMed id 17589504)1, 2, 3 Maria Fimia G.... Cecconi F. (Nature 2007)
    2. A novel role for autophagy in neurodevelopment. (PubMed id 17622796)1, 3 Cecconi F....Piacentini M. (Autophagy 2007)
    3. Autophagy: a new regulator of development. (PubMed id 17603510)1, 3 Le Bot N. (Nat. Cell Biol. 2007)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    5. Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 11214970)1, 2 Nagase T.... Ohara O. (DNA Res. 2000)
    6. Ambra1 at the crossroad between autophagy and cell death. (PubMed id 23069654)1 Fimia G.M....Piacentini M. (Oncogene 2013)
    7. WASH inhibits autophagy through suppression of Beclin 1 ubiquitination. (PubMed id 23974797)1 Xia P....Fan Z. (EMBO J. 2013)
    8. Prognostic significance of autophagy-related protein expression in resected pancreatic ductal adenocarcinoma. (PubMed id 23429496)1 Ko Y.H....Lee M.A. (Pancreas 2013)
    9. Beclin 2 functions in autophagy, degradation of G protein-coupled receptors, and metabolism. (PubMed id 23954414)2 He C.... Levine B. (Cell 2013)
    10. From gene to brain to behavior: schizophrenia-associated variation in AMBRA1 alters impulsivity-related traits. (PubMed id 23551272)1 Heinrich A....Rietschel M. (Eur. J. Neurosci. 2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 55626 HGNC: 25990 AceView: FLJ20294 Ensembl:ENSG00000110497 euGenes: HUgn55626
    ECgene: AMBRA1 H-InvDB: AMBRA1

    (According to HUGE)
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    HUGE: KIAA1736

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for AMBRA1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for AMBRA1 gene:
    Search GeneIP for patents involving AMBRA1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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