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AMBP Gene

protein-coding GIFtS: 59

GC09M115862

alpha-1-microglobulin/bikunin precursor
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbols: ITI, ITIL)

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
EDC1 ^¹, ²
HCP ^¹, ², ³, ⁵
HI30 ^¹, ²
IATIL ^¹, ²
ITI ^², ⁵
ITIL ^², ³, ⁵
ITILC ^¹, ²
OTTHUMP00000021967 ^²
OTTHUMP00000063975 ^²
UTI ^¹, ²
alpha-1-microglobulin/bikunin ^²
bikunin ^²
trypstatin ^²
uristatin ^²

Descriptions
alpha-1-microglobulin/bikunin precursor ^²
complex-forming glycoprotein heterogeneous in charge ^²
growth-inhibiting protein 19 ^²
inter-alpha-trypsin inhibitor light chain ^²
protein HC ^²
uronic-acid-rich protein ^²

External Ids
HGNC: 453¹
Entrez Gene: 259²
UniProtKB: P02760³
Ensembl: ENSG00000106927⁷

Search outside databases for aliases for AMBP gene

Previous GC identifers: GC09M107620 GC09M108554 GC09M110276 GC09M112198 GC09M113901

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for AMBP:

This gene encodes a complex glycoprotein secreted in plasma. The precursor is proteolytically

processed into distinct functioning proteins: alpha-1-microglobulin, which belongs to the

superfamily of lipocalin transport proteins and may play a role in the regulation of inflammatory

processes, and bikunin, which is a urinary trypsin inhibitor belonging to the superfamily of

Kunitz-type protease inhibitors and plays an important role in many physiological and pathological

processes. This gene is located on chromosome 9 in a cluster of lipocalin genes. [provided by

RefSeq]

UniProtKB/Swiss-Prot: AMBP_HUMAN, P02760

Function: Trypstatin is a trypsin inhibitor (By similarity)

Gene Wiki entry for AMBP (Alpha-1-microglobulin/bikunin_precursor)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the AMBP gene

Entrez Gene cytogenetic band: 9q32-q33 Ensembl cytogenetic band: 9q32 HGNC cytogenetic band: 9q32-q33

AMBP Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 9 GeneLoc Exon Structure

GeneLoc location for GC09M115862: (about GC identifiers)

Start:	115,862,228 bp from pter
End:	115,880,536 bp from pter
Size:	18,309 bases
Orientation:	minus strand

RefSeq DNA sequence:

NC_000009.10 NT_008470.18

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: AMBP_HUMAN, P02760 (See protein sequence)

Recommended Name: Protein AMBP precursor

Size: 352 amino acids; 38999 Da

Subunit: I-alpha-I plasma protease inhibitors are assembled from one or two heavy chains (H1, H2 or

H3) and one light chain, bikunin. Inter-alpha-inhibitor (I-alpha-I) is composed of H1, H2 and

bikunin, inter-alpha-like inhibitor (I-alpha-LI) of H2 and bikunin, and pre-alpha-inhibitor

(P-alpha-I) of H3 and bikunin. Alpha-1-microglobulin occurs as a monomer and also in complexes

with IgA and albumin. Alpha-1-microglobulin interacts with FN1. Trypstatin is a monomer and also

occurs as a complex with tryptase in mast cells (By similarity). Alpha-1-microglobulin and bikunin

interact (via SH3 domain) with HEV ORF3 protein

Subcellular location: Secreted

Miscellaneous: In vitro, the first twelve residues of the amino end of the inhibitor appear to have

a reactive site capable of inhibiting the activity of a number of enzymes. Its in vivo function is

not known

PDB structures from and Proteopedia :

1BIK (3D)

Secondary accessions: P00977 P02759 P78491 Q2TU33 Q5TBD7 Q9UC58 Q9UDI8

Post-translational modifications:

The precursor is proteolytically processed into separately functioning proteins¹

3-hydroxykynurenine, an oxidized tryptophan metabolite that is common in biological fluids, reacts

with Cys-53, Lys-111, Lys-137, and Lys-149 to form heterogeneous polycyclic chromophores including

hydroxanthommatin. The reaction by alpha-1-microglobulin is autocatalytic; the human protein forms

chromophore even when expressed in insect and bacterial cells. The chromophore can react with

accessible cysteines forming non-reducible thioether cross-links with other molecules of

alpha-1-microglobulin or with other proteins such as Ig alpha-1 chain C region 'Cys-352'¹

Heavy chains are interlinked with bikunin via a chondroitin 4-sulfate bridge to the their

C-terminal aspartate (By similarity)¹

Addition of glycosaminoglycan chondroitin sulfate, allows cross-linking between the different

components¹

View phosphorylation sites using PhosphoSite²

REFSEQ proteins: NP_001624.1

ENSEMBL proteins:

ENSP00000265132

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Sigma-Aldrich Proteins for AMBP
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (Microglobulin (alpha 1), Bikunin)
	Human Recombinant Proteins from Abnova (AMBP)

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

2 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005576	extracellular region	NAS	11877257 14718574
GO:0005886	plasma membrane	IDA	12817471

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Antibodies for AMBP:

	Browse Antibodies Central at Invitrogen
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Sigma-Aldrich Antibodies for AMBP
	Browse R&D Systems for Antibodies
	Antibodies from Abcam (Microglobulin (alpha 1), Bikunin), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (AMBP)
	Novus Biologicals Antibodies for AMBP

Assays for AMBP:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry P02760

ProtoNet protein and cluster: P02760

3 Blocks protein families:

IPB002223 Pancreatic trypsin inhibitor (Kunitz)

IPB002345 Lipocalin signature

IPB002968 Alpha-1-microglobulin signature

UniProtKB/Swiss-Prot: AMBP_HUMAN, P02760

Similarity: In the N-terminal section; belongs to the calycin superfamily. Lipocalin family

Similarity: Contains 2 BPTI/Kunitz inhibitor domains

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (AMBP)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (AMBP)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_001633

Applied Biosystems Silencer® siRNAs for AMBP

Sigma-Aldrich siRNA for AMBP

Sigma-Aldrich shRNA for AMBP

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for AMBP
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_001633
Myc/DDK tagged cDNA clone in CMV expression vector: NM_001633
untagged cDNA clone in CMV expression vector: NM_001633

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_001633

UniProtKB/Swiss-Prot: AMBP_HUMAN, P02760

Function: Inter-alpha-trypsin inhibitor inhibits trypsin, plasmin, and lysosomal granulocytic

elastase. Inhibits calcium oxalate crystallization

Function: Trypstatin is a trypsin inhibitor (By similarity)

Genatlas biochemistry entry for AMBP:

alpha-1-microglobulin (HC,lipocalin family Kernel group),expressed in plasma either as a free form

or in covalent complexes with albumine IgA and bikunin precursor (ITIL),complexing with

ITIH1,ITIH2, ITIH3 or ITIH4,to form alpha type inhibitor (respectively inter- and pre-)

4 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Ambp):

behavior/neurological

embryogenesis

endocrine/exocrine gland

reproductive system

5/6 Gene Ontology (GO) molecular function terms (links to tree view) (see all 6 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005215	transporter activity	IEA	--
GO:0019855	calcium channel inhibitor activity	NAS	12817471
GO:0019862	IgA binding	IDA	11877257
GO:0020037	heme binding	IDA	11877257
GO:0042803	protein homodimerization activity	IPI	11883904

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

1 Sigma-Aldrich "Your Favorite Gene" Pathway for AMBP (Your Favorite Gene powered by Ingenuity)

Acute Phase Response Signaling

GeneDecks AMBP for the pathways selected above

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Gene Network Central^TM Interacting Genes and Proteins Network for AMBP

5/18 Interacting proteins for AMBP (ENSP00000265132³ P02760²) via UniProtKB, MINT, and/or STRING (see all 18 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
CTSB	P07858²	MINT-73534 MINT-73532 MINT-73533 MINT-73528
A2M	ENSP00000323929³	STRING (score=.969)
ITIH4	ENSP00000266041³	STRING (score=.967)
ITIH2	ENSP00000351190³	STRING (score=.955)
F8	ENSP00000327895³	STRING (score=.952)

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5/8 Gene Ontology (GO) biological process terms (links to tree view) (see all 8 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006810	transport	IEA	--
GO:0007155	cell adhesion	NAS	9570066
GO:0007565	female pregnancy	NAS	10097787
GO:0018298	protein-chromophore linkage	IEA	--
GO:0042167	heme catabolic process	NAS	11877257

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for AMBP
10/32 Novoseek chemical compound relationships for AMBP gene (see all 32 )

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
calcium oxalate	75.99	39	14516400 (3), 10092156 (3), 10541269 (3), 9607205 (2) (see all 15)
alpha 2 macroglobulin	75.31	2	9837695 (1)
chondroitin sulfate	68.35	30	7680011 (2), 1708671 (2), 18247611 (2), 11322893 (1) (see all 18)
chondroitin	53.95	1	7680011 (1)
glycosaminoglycan	53.64	10	8593487 (2), 1794445 (1), 7528540 (1), 9677337 (1) (see all 9)
99mtc-dmsa	45.19	1	2197478 (1)
cadmium	44.66	17	9816376 (4), 7683309 (3), 9098909 (2), 17943303 (2) (see all 8)
polyacrylamide	43.83	11	7680331 (1), 7512818 (1), 1718393 (1), 1382972 (1) (see all 8)
hanp	41.04	2	1287423 (1), 8219653 (1)
heparan sulfate	25.30	3	15235923 (1), 14977559 (1)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (AMBP)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (AMBP)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_001633

Sigma-Aldrich siRNA for AMBP

Sigma-Aldrich shRNA for AMBP

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_001633

REFSEQ mRNAs for AMBP gene:

NM_001633.3

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_001633

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_001633
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_001633
                                 untagged cDNA clone in CMV expression vector: NM_001633

Additional cDNA sequence:

AK290837.1 AK303795.1 AK310776.1 AK310791.1 AY544123.1 BC041593.1 CR607981.1 CR615737.1

CR616173.1 M11562.1 X04225.1 X04494.1

10 DOTS entries:

DT.454719 DT.100878286 DT.92460856 DT.95156021 DT.92460868 DT.100878287 DT.95164087 DT.95164092

DT.95164112 DT.95164091

24/416 AceView cDNA sequences (see all 416 ):

CB156785 AV646247 CB164007 BM742633 T72138 AV652004 X04494 AV656943

AV657651 AV645689 NM_001633 CA866523 AV654397 AV653939 AV659596 AV653347

AV646210 AA343929 AV654216 AV646204 AV646174 X04225 CR616173 AV695187

highest scoring ESTs for AMBP:

AI133364 AV656943 AV656956 AV692644 BC041593 BG616673 BI252255 BI918693 BM005934 BM742633

Unigene Cluster for AMBP:

Alpha-1-microglobulin/bikunin precursor

Hs.436911 [show with all ESTs]

Unigene Representative Sequence: NM_001633

GeneLoc Exon Structure

1 Ensembl transcript including schematic representation:

ENST00000265132

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

AMBP expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for AMBP

¹ / ² / ³

3 probe-sets matching AMBP gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
36995_at²^{, 3}	U95-A	1	1.00	1.00	1.00	1.00	M88249	0.20	1.00	0.72	1
205477_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_001633	0.60	1.00	0.82	1
205477_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

GeneDecks AMBP for binary patterns associated with the probe-sets selected above

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Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: GGCAACGGTA

SOURCE GeneReport for Unigene cluster: Hs.436911
Expression variation in blood from EXPOLDB for AMBP
UniProtKB/Swiss-Prot: AMBP_HUMAN, P02760
Tissue specificity: Expressed by the liver and secreted in plasma. Alpha-1-microglobulin occurs in
many physiological fluids including plasma, urine, and cerebrospinal fluid. Inter-alpha-trypsin
inhibitor is present in plasma and urine

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for AMBP gene from 5/9 species (see all 9 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	AMBP¹	--	alpha-1-microglobulin/bikunin precursor	81.09(n) 78.51(a)	481685 XM_538807.2 XP_538807.2
chimpanzee (Pan troglodytes)	AMBP¹	--	alpha-1-microglobulin/bikunin precursor	99.34(n) 99.14(a)	742026 XM_001155186.1 XP_001155186.1
cow (Bos taurus)	AMBP¹	--	alpha-1-microglobulin/bikunin precursor	81.16(n) 77.27(a)	280996 NM_173989.2 NP_776414.1
rat (Rattus norvegicus)	Ambp¹	--	alpha-1-microglobulin/bikunin precursor	79.21(n) 76.44(a)	25377 NM_012901.1 NP_037033.1
mouse (Mus musculus)	Ambp^{1, 5}	4 (30.60 cM)⁵	alpha 1 microglobulin/bikunin^{1, 5}	78.83(n)¹ 76.44(a)¹	11699¹ NM_007443.2¹ NP_031469.1¹ AF034692⁵ AI194774⁵ (see all 9)

About this table Species with no ortholog for AMBP

ENSEMBL Gene Tree for AMBP

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for AMBP gene

SPINT2² TFPI2² TFPI²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/121 NCBI SNPs in AMBP are shown (see all 121 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 74)

AB	SNP ID	Valid	Chr 9 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--				--
	rs1982049^1,2	A,C,F,H,O	115882466(+)	`GATTAG/TATTCC`	1	--	ng3¹		13		EA NA EU WA	2534
	rs1982048^1,2	A,C,F,H	115882317(+)	`CCCCAC/TGTAGT`	1	--	ng3¹		8		EU EA WA	836
	rs12554342^1,2	A,C,F,H	115880622(+)	`CCCCAC/GAGAGG`	1	--	ng3¹		8		EU EA WA	840
	rs2761691^1,2	A,C,F,H	115881563(-)	`TTGGTT/GATTTT`	1	--	ng3¹		4		EU EA WA	410
	rs3762058^1,2	C,F,H	115882154(+)	`TTTCCC/TTTCTC`	1	--	ng3¹ trp³		12		EA NA EU WA	2458
	rs2285055^1,2	C,F,H	115881001(-)	`ACTTCA/GTAAGC`	1	--	ng3¹		9		EA EU WA	2120
	rs2251700^1,2	A,C	115880593(-)	`CCCAAC/TCCTGG`	1	--	ng3¹		0	--	--	--	--
--	rs10759681^1,2	A,C	115881981(+)	`ACTCCC/TGACCT`	1	--	ng3¹ tfbs³		0	--	--	--	--
--	rs10982058^1,2	A	115881572(+)	`AAGGAC/TTGATG`	1	--	ng3¹ tfbs³		0	--	--	--	--
	rs6478056^1,2	A,C,F,H	115868629(+)	`acagaA/Gtaaga`	1	--	int¹		4		EU EA WA	418

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HapMap Linkage Disequilibrium images for AMBP (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 176870

10/68 Novoseek disease relationships for AMBP gene (see all 68 )

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
proteinuria	72.65	25	7554530 (2), 7685986 (1), 9072628 (1), 9395812 (1) (see all 21)
microalbuminuria	62.76	5	7532743 (2), 1533771 (1)
renal disease	58.23	15	1370761 (1), 8969545 (1), 9072628 (1), 12399625 (1) (see all 15)
albuminuria	56.47	4	10332434 (1), 9078324 (1), 7691491 (1), 7554530 (1)
renal stone	53.36	5	10092156 (2), 11435884 (1), 10541279 (1)
diabetic nephropathies	51.91	2	9342486 (1), 8593760 (1)
kidney dysfunction	51.55	1	9072628 (1)
response acute phase	41.19	4	7532586 (1), 15709178 (1), 1285244 (1)
vesicoureteral reflux	39.07	2	8969545 (1), 7681890 (1)
urolithiasis	38.73	4	11435884 (1), 16104926 (1), 9680501 (1), 12230607 (1)

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(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
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10/432 PubMed articles for AMBP gene (see all 432 ):

Structure of the human alpha 1-microglobulin-bikunin gene. (PubMed id 1708673)^{1, 2, 3, 4} Vetr H. and Gebhard W. (1990)
Homologous chromosomal locations of the four genes for inter-alpha-inhibitor and pre-alpha-inhibitor family in human and mouse: assignment of the ancestral gene for the lipocalin superfamily. (PubMed id 1385302)^{1, 2, 3} Salier J.P....Mattei M.G. (1992)
The 41-amino-acid C-terminal region of the hepatitis E virus ORF3 protein interacts with bikunin, a kunitz-type serine protease inhibitor. (PubMed id 16140784)^{1, 3, 4} Tyagi S....Lal S.K. (2005)
Presence of the protein-glycosaminoglycan-protein covalent cross-link in the inter-alpha-inhibitor-related proteinase inhibitor heavy chain 2/bikunin. (PubMed id 7682553)^{1, 3, 4} Enghild J.J....Hefta S.A. (1993)
Chondroitin sulphate covalently cross-links the three polypeptide chains of inter-alpha-trypsin inhibitor. (PubMed id 7513643)^{1, 3, 4} Morelle W.... Mizon J. (1994)
The ORF3 protein of hepatitis E virus interacts with liver-specific alpha1-microglobulin and its precursor alpha1-microglobulin/bikunin precursor (AMBP) and expedites their export from the hepatocyte. (PubMed id 15037615)^{1, 3, 4} Tyagi S....Lal S.K. (2004)
Human alpha-1-microglobulin is covalently bound to kynurenine-derived chromophores. (PubMed id 15452109)^{3, 4} Sala A.... Galliano M. (2004)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)
Alpha(1)-microglobulin: a yellow-brown lipocalin. (PubMed id 11058759)^{3, 4} Akerstroem B.... Lindqvist A. (2000)
Alpha1-microglobulin chromophores are located to three lysine residues semiburied in the lipocalin pocket and associated with a novel lipophilic compound. (PubMed id 10631976)^{3, 4} Berggard T.... Akerstroem B. (1999)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 259	HGNC: 453	AceView: AMBP	Ensembl:ENSG00000106927	euGenes: HUgn259
ECgene: AMBP	H-InvDB: AMBP

(According to HUGE)
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(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Licensable Technologies for AMBP
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for AMBP:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

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Antibodies for AMBP

GeneCards Homepage - Last full update: 2 Jul 2009 Incremental update: 13 Oct 2009

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Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

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AMBP Gene at Home site.
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AMBP Gene

protein-coding GIFtS: 59

Aliases &
Descriptions
for AMBP

Summaries
for AMBP

Genomic Location
for AMBP

Proteins
for AMBP

Protein Domains/
Families
for AMBP

Gene Function
for AMBP

Pathways & Interactions
for AMBP

Drugs & Compounds
for AMBP

Transcripts
for AMBP

Expression
for AMBP

Orthologs
for AMBP

Paralogs
for AMBP

SNPs/Variants
for AMBP

Disorders & Mutations
for AMBP

Medical News
for AMBP

Publications
for AMBP

Search for AMBP

Genome Databases showing AMBP

Other Databases showing AMBP

Specialized Databases showing AMBP

Licensable Technologies
for AMBP

Services
for AMBP

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

AMBP (Gene Symbol)
EDC1
HCP
HI30
IATIL
ITI
ITIL
ITILC
OTTHUMP00000021967
OTTHUMP00000063975
UTI
alpha-1-microglobulin/bikunin
bikunin
trypstatin
uristatin
alpha-1-microglobulin/bikunin precursor
complex-forming glycoprotein heterogeneous in charge
growth-inhibiting protein 19
inter-alpha-trypsin inhibitor light chain
protein HC
uronic-acid-rich protein

AMBP Gene

protein-coding GIFtS: 59

Aliases & Descriptionsfor AMBP

Summariesfor AMBP

Genomic Locationfor AMBP

Proteinsfor AMBP

Protein Domains/Familiesfor AMBP

Gene Functionfor AMBP

Pathways & Interactionsfor AMBP

Drugs & Compoundsfor AMBP

Transcriptsfor AMBP

Expression for AMBP

Orthologsfor AMBP

Paralogsfor AMBP

SNPs/Variantsfor AMBP

Disorders & Mutationsfor AMBP

Medical Newsfor AMBP

Publicationsfor AMBP

Search for AMBP

Genome Databases showing AMBP

Other Databases showing AMBP

Specialized Databases showing AMBP

Licensable Technologiesfor AMBP

Servicesfor AMBP

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for AMBP

Summaries
for AMBP

Genomic Location
for AMBP

Proteins
for AMBP

Protein Domains/
Families
for AMBP

Gene Function
for AMBP

Pathways & Interactions
for AMBP

Drugs & Compounds
for AMBP

Transcripts
for AMBP

Expression
for AMBP

Orthologs
for AMBP

Paralogs
for AMBP

SNPs/Variants
for AMBP

Disorders & Mutations
for AMBP

Medical News
for AMBP

Publications
for AMBP

Licensable Technologies
for AMBP

Services
for AMBP