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Aliases & Descriptions for AMBN
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase) About This Section
|
| | | Descriptions |
|---|
| ameloblastin (enamel matrix protein) 2 | | ameloblastin, enamel matrix protein 1 |
|
| | Search outside databases for aliases for AMBN genePrevious GC identifers: GC04U990004 GC04M9L0081 GC04P071774 GC04P071638 |
Summaries for AMBN(According to Entrez Gene,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| EntrezGene summary for AMBN: Ameloblastin is thought to represent an unique ameloblast-specific gene product that may be important in enamel matrix formation and mineralization. The gene is located on chromosome 4 near other genes associated with mineralized tissues: osteopontin, bone sialoprotein, and bone morphogenetic protein 3. Based on its cytogenetic location, this gene is a candidate gene for one form of the disorder, dentinogenesis imperfecta, and/or the disorder, autosomal dominant amylogenesis imperfecta. [provided by RefSeq] UniProtKB/Swiss-Prot: AMBN_HUMAN, Q9NP70Function: Involved in the mineralization and structural organization of enamel |
Genomic Location for AMBN
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to
UCSC and
Ensembl,
Transcription factor binding sites according to
SABiosciences) About This Section
| Genomic View: UCSC Golden Path with GeneCards custom track
Transcription factor binding sites upstream to the AMBN gene 
Entrez Gene cytogenetic band: 4q21 Ensembl cytogenetic band: 4q13.3 HGNC cytogenetic band: 4q21AMBN Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)
 GeneLoc gene densities for chromosome 4 GeneLoc Exon Structure GeneLoc location for GC04P071506:
(about GC identifiers)
Start:
|
71,492,582 bp from pter |
End:
|
71,507,594 bp from pter |
Size:
|
15,013 bases |
Orientation:
|
plus strand |
RefSeq DNA sequence:- NC_000004.10 NT_077444.3
| Proteins for AMBN
(According to
1UniProtKB,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Enzo Life Sciences,
Abnova,
OriGene and/or,
Abcam,
Biochemical Assays by
Invitrogen,
Millipore,
R&D Systems,
Cell Signaling Technology, and/or
Enzo Life Sciences,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene,
Antibodies by Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Cell Signaling Technology,
Abcam,
Abnova, and/or
Novus Biologicals)
About This Section
| UniProtKB/Swiss-Prot: AMBN_HUMAN, Q9NP70 (See
protein sequence)Recommended Name: Ameloblastin precursor Size: 447 amino acids; 48283 Da
Subcellular location: Secreted, extracellular space, extracellular matrix
Secondary accessions: Q9H2X1 Q9H4L1Alternative splicing: 2 isoforms: Q9NP70-1 Q9NP70-2 REFSEQ proteins: NP_057603.1
ENSEMBL proteins: ENSP00000313809
Human Recombinant Proteins Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 
2 Gene Ontology (GO) cellular component terms (links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005576 | extracellular region |
IEA | -- | | GO:0005578 | proteinaceous extracellular matrix |
NAS | -- | About this table
Antibodies for AMBN: Assays for AMBN: | Protein
Domains/ Families for AMBN(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| - Graphical View of Domain Structure for InterPro Entry Q9NP70
ProtoNet protein and cluster: Q9NP70 1 Blocks protein family: IPB007798 Ameloblastin precursor
UniProtKB/Swiss-Prot: AMBN_HUMAN, Q9NP70Similarity: Belongs to the ameloblastin family | Gene Function for AMBN
(According to MGI Jun 06 2009, UniProtKB,
IUBMB,and/or Genatlas,
shRNA from
OriGene,
Sigma-Aldrich, RNAi from
Sigma-Aldrich,
RNAi Products,
Clones, and
Q-PCR Products
from Invitrogen,
Millipore,
OriGene, and/or
Abnova,
siRNAs from
Applied Biosystems,
SYBR primers from OriGene,
Cell-based Assays from Millipore,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_016519
Applied Biosystems Silencer® siRNAs for AMBN
Sigma-Aldrich siRNA for AMBN  Sigma-Aldrich shRNA for AMBN  Explore Sigma-Aldrich super-pooled esiRNAs 
              OriGene GFP tagged cDNA clone in CMV expression vector: NM_016519                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_016519                                  untagged cDNA clone in CMV expression vector: NM_016519 
Primers: Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers               OriGene genome-wide validated SYBR primer pairs: NM_016519
UniProtKB/Swiss-Prot: AMBN_HUMAN, Q9NP70Function: Involved in the mineralization and structural organization of enamelGenatlas biochemistry entry for AMBN:ameloblastin,enamel sheath protein3 MGI mutant phenotypes (inferred from 1 allele ) (MGI details for Ambn):
2 Gene Ontology (GO) molecular function terms (links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0008083 | growth factor activity |
ISS | -- | | GO:0030345 | structural constituent of tooth enamel |
NAS | -- | About this table | Pathways & Interactions for AMBN
(Pathways according to Invitrogen
(maps by GeneGo),
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Proteins Network according to
SABiosciences,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|
5/14 Interacting proteins for AMBN (ENSP000003138093) via UniProtKB, MINT, and/or STRING (see all 14
)About this table
4 Gene Ontology (GO) biological process terms (links to tree view): About this table
|
Drugs & Compounds for AMBN(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
Browse Tocris compounds for AMBN
|
Transcripts for AMBN(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from Invitrogen,
Millipore, and/or
Abnova,
siRNAs from Applied Biosystems,
Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
Tagged/untagged cDNA clones from
OriGene, Expression Assays from Applied Biosystems) About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_016519
Sigma-Aldrich siRNA for AMBN  Sigma-Aldrich shRNA for AMBN  Explore Sigma-Aldrich super-pooled esiRNAs 
Applied Biosystems Silencer® siRNAs: NM_016519 REFSEQ mRNAs for AMBN gene: NM_016519.4
Applied Biosystems TaqMan ® Gene Expression Assays: NM_016519               OriGene GFP tagged cDNA clone in CMV expression vector: NM_016519                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_016519                                  untagged cDNA clone in CMV expression vector: NM_016519  Additional cDNA sequence: AF209780.1 AF219994.2 AF263464.1 AJ537437.1 AK314918.1 BC106931.1 BC106932.1 1 DOTS entry: DT.91666448 15 AceView cDNA sequences:NM_016519 AF219994 AJ537437 AF263464 AF209780 BG213392 BG208788 BG208157 BG218715 BG195227 BG190153 BG186598 BG200369 BG214473 BG194708
highest scoring ESTs for AMBN:AF209780 AF219994 AF263464 AJ537437 BG186598 BG195227 BG208788 BG213392 BG190153 BG193219 Unigene Cluster for AMBN: Ameloblastin (enamel matrix protein) Hs.272396 [show with all ESTs]Unigene Representative Sequence: AF209780
GeneLoc Exon Structure
2 Alternative Splicing Database (ASD) splice patterns (SP) for AMBN
| ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6a | · | 6b | ^ | 7a | · | 7b | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13 | |
| SP1: | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |
| SP2: | |   | |   | |   | |   | |   | - |   | |   | |   | |   | |   | |   | |   | |   | |   | |   |
About this scheme
ECgene alternative splicing isoforms for AMBN
1 Ensembl transcript including schematic representation: ENST00000322937
|
Expression for AMBN
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Expression Assays from
Applied Biosystems
)
About This Section
| AMBN expression in normal and diseased human tissues
Applied Biosystems TaqMan ® Gene Expression Assays for AMBN
1 / 2 / 3 2 probe-sets matching AMBN gene Data from
(Publications) and GNF BioGPS About these images About these images
CGAP SAGE TAG: GCATTTCCAA
SOURCE GeneReport for Unigene cluster: Hs.272396 UniProtKB/Swiss-Prot: AMBN_HUMAN, Q9NP70Tissue specificity: Ameloblast-specific. Located at the Tomes processes of secretory ameloblasts and in the sheath space between rod-interrod enamel |
Orthologs for AMBN
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for AMBN gene from 5 species
About this table Species with no ortholog for AMBN
ENSEMBL Gene Tree for AMBN | Paralogs for AMBN(Paralogs according to 1HomoloGene and 2Ensembl, Pseudogenes according to 3Pseudogene.org) About This Section
| -- |
SNPs/Variants for AMBN(According to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Genotyping Reagents from
Applied Biosystems)
About This Section
|
HapMap Linkage Disequilibrium images for AMBN (up to first 250kb)
|
Disorders & Mutations for AMBN
(in which this Gene is Involved, According to
OMIM, UniProtKB,
Novoseek, PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
HGMD, GAD,
HuGE Navigator,
BCGD,
and/or TGDB.)
About This Section
|
OMIM: 601259
UniProtKB/Swiss-Prot: AMBN_HUMAN, Q9NP70
Defects in AMBN are found in patients with ameloblastomas3 Novoseek disease relationships for AMBN gene
About this table
Human Genome Epidemiology Navigator: AMBN (1 document)
|
Medical News for AMBN(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications for AMBN (in
PubMed.
Associations of this gene to articles via
1Novoseek,
2HGNC,
3Entrez Gene,
4UniProtKB/Swiss-Prot,
5UniProtKB/TrEMBL,
6GAD, and/or
7PharmGKB)
About This Section
| 10/53 PubMed articles for AMBN gene (see all 53
):- Cloning, characterization and immunolocalization of human ameloblastin. (PubMed id 10946765)1, 3, 4 MacDougall M.... Berdal A. (2000)
- Ameloblastin gene (AMBN) maps within the critical region for autosomal dominant amelogenesis imperfecta at chromosome 4q21. (PubMed id 9126491)1, 2, 3 MacDougall M....Forsman K. (1997)
- Human ameloblastin gene: genomic organization and mutation analysis in amelogenesis imperfecta patients. (PubMed id 11330937)1, 3, 4 Mardh C.K.... Forsman-Semb K. (2001)
- Cloning and characterization of the human ameloblastin gene. (PubMed id 11054529)1, 3, 4 Toyosawa S.... Ijuhin N. (2000)
- Bioinformatic analysis and molecular modelling of human ameloblastin suggest a two-domain intrinsically unstructured calcium-binding protein. (PubMed id 18353005)1, 3 Vymetal J....Lyngstadaas S.P. (2008)
- Ameloblastin expression in rat incisors and human tooth germs. (PubMed id 9032019)1, 3 Lee S.K....Yamada Y. (1996)
- Enamel formation genes are associated with high caries experience in Turkish children. (PubMed id 18781068)1, 3 Patir A....Vieira A.R. (2008)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)3 Strausberg R.L....Marra M.A. (2002)
- Hepatitis C virus core protein interacts with 14-3-3 protein and activates the kinase Raf-1. (PubMed id )4 Aoki H.... Hino O. (2000)
- Proteinases in developing dental enamel. (PubMed id 10634581)3 Bartlett J.D. and Simmer J.P. (1999)
|
Search for AMBN
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
|
|
Genome Databases showing AMBN
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
and/or
H-InvDB)
About This Section
|
| Other Databases showing AMBN
(According to HUGE)
About This Section
| -- |
Specialized Databases showing AMBN(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
|
| About This Section
| --
| Services for AMBN(Reagents available from Applied Biosystems, Antibodies and assays by Cell
Signaling Technology, Abcam, Novus Biologicals, Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich, Enzo Life Sciences, and/or Tocris Bioscience) About This Section
| 
 Products for AMBN:

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