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AMACR Gene

protein-coding GIFtS: 66

GC05M034023

alpha-methylacyl-CoA racemase
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
CBAS4 ^², ⁵
EC 5.1.99.4 ^³
RACE ^¹, ²

Descriptions
2-methylacyl-CoA racemase ^³
alpha-methylacyl-CoA racemase ^²

External Ids
HGNC: 451¹
Entrez Gene: 23600²
UniProtKB: Q9UHK6³
Ensembl: ENSG00000082196⁷

Search outside databases for aliases for AMACR gene

Previous GC identifers: GC05M033933 GC05M034446 GC05M034032 GC05M034033

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for AMACR:

Alpha-methylacyl-CoA racemase is responsible for the conversion of pristanoyl-CoA and C27-bile

acyl-CoAs to their (S)-stereoisomers, which are the only stereoisomers that can be degraded via

peroxisomal beta-oxidation.[supplied by OMIM]

UniProtKB/Swiss-Prot: AMACR_HUMAN, Q9UHK6

Function: Racemization of 2-methyl-branched fatty acid CoA esters. Responsible for the conversion

of pristanoyl-CoA and C27-bile acyl-CoAs to their (S)-stereoisomers

Gene Wiki entry for AMACR

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the AMACR gene

Entrez Gene cytogenetic band: 5p13 Ensembl cytogenetic band: 5p13.3 HGNC cytogenetic band: 5p13.2-q11.1

AMACR Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 5 GeneLoc Exon Structure

GeneLoc location for GC05M034023: (about GC identifiers)

Start:	34,023,069 bp from pter
End:	34,160,396 bp from pter
Size:	137,328 bases
Orientation:	minus strand

RefSeq DNA sequence:

NC_000005.8 NT_006576.15

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: AMACR_HUMAN, Q9UHK6 (See protein sequence)

Recommended Name: Alpha-methylacyl-CoA racemase

Size: 382 amino acids; 42360 Da

Subcellular location: Peroxisome. Mitochondrion

Sequence caution: Sequence=CAB44062.1; Type=Frameshift; Positions=62, 65, 114;

Secondary accessions: A5YM47 B8Y916 B8Y918 O43673 Q96GH1 Q9Y3Q1

Alternative splicing: 4 isoforms: Q9UHK6-1 Q9UHK6-2 Q9UHK6-3 Q9UHK6-4

REFSEQ proteins (2 alternative transcripts):

NP_055139.4 NP_976316.1

ENSEMBL proteins:

ENSP00000371488 ENSP00000371497 ENSP00000371511 ENSP00000231338 ENSP00000371500 ENSP00000371504

ENSP00000334424 ENSP00000371517

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (AMACR + p63, AMACR)
	Human Recombinant Proteins from Abnova (AMACR)

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

2 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005739	mitochondrion	TAS	10770938
GO:0005777	peroxisome	TAS	10770938

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Antibodies for AMACR:

	Invitrogen Antibodies for AMACR
	Millipore Mono- and Polyclonal Antibodies for the study of AMACR
	Sigma-Aldrich Antibodies for AMACR
	Browse R&D Systems for Antibodies
	Cell Signaling Technology (CST) Antibodies for AMACR
	Antibodies from Abcam (AMACR + p63, AMACR), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (AMACR)
	Novus Biologicals Antibodies for AMACR

Assays for AMACR:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry Q9UHK6

ProtoNet protein and cluster: Q9UHK6

1 Blocks protein family: IPB003673 L-carnitine dehydratase/bile acid-inducible protein F

UniProtKB/Swiss-Prot: AMACR_HUMAN, Q9UHK6

Similarity: Belongs to the caiB/baiF CoA-transferase family

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (AMACR)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (AMACR)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_014324

Applied Biosystems Silencer® siRNAs for AMACR

Sigma-Aldrich siRNA and siRNA Panels for AMACR

Sigma-Aldrich shRNA for AMACR

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for AMACR
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_014324
Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_014324
untagged cDNA clones in CMV expression vector (see all 2): NM_014324

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_014324

UniProtKB/Swiss-Prot: AMACR_HUMAN, Q9UHK6

Function: Racemization of 2-methyl-branched fatty acid CoA esters. Responsible for the conversion

of pristanoyl-CoA and C27-bile acyl-CoAs to their (S)-stereoisomers

Catalytic activity: (2S)-2-methylacyl-CoA = (2R)-2-methylacyl-CoA

Enzyme Number (IUBMB): EC 5.1.99.4

Genatlas biochemistry entry for AMACR:

alpha-methylacyl-CoA racemase,expressed in liver,peroxisomal,converting pristanoyl-CoA and C27 beta

acyl-CoA to their (5) stereoisomers,essential step for the formation of cholic acid by the normal

peroxisomal pathway

5 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Amacr):

adipose tissue

growth/size

homeostasis/metabolism

life span-post-weaning/aging

liver/biliary system

2 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0008111	alpha-methylacyl-CoA racemase activity	IEA	--
GO:0016853	isomerase activity	IEA	--

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

UniProtKB/Swiss-Prot: AMACR_HUMAN, Q9UHK6

Pathway: Lipid metabolism; bile acid biosynthesis

Pathway: Lipid metabolism; fatty acid metabolism

5/14 Interacting proteins for AMACR (ENSP00000371517³) via UniProtKB, MINT, and/or STRING (see all 14 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
ACOX3	ENSP00000348775³	STRING (score=.965)
ACOX2	ENSP00000307697³	STRING (score=.958)
OR51E2	ENSP00000337929³	STRING (score=.924)
OR51E1	ENSP00000325744³	STRING (score=.902)
OR1D2	ENSP00000327585³	STRING (score=.752)

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1 Gene Ontology (GO) biological process term (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0008152	metabolic process	IEA	--

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for AMACR
10/21 Novoseek chemical compound relationships for AMACR gene (see all 21 )

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
trihydroxycholestanoic acid	84.17	3	11160375 (1), 11060359 (1), 11861706 (1)
pristanic acid	80.60	14	11893780 (2), 11060359 (2), 11160375 (1), 10709653 (1) (see all 9)
phytanic acid	69.21	8	15712232 (1), 18080240 (1), 12917210 (1), 11948235 (1) (see all 6)
ddp-cr	52.51	2	9196290 (1), 11460706 (1)
acyl-coa	31.46	8	11473573 (2), 11356171 (1), 11992265 (1), 9803880 (1)
oligonucleotide	26.69	4	11126119 (1), 7589466 (1), 17208011 (1), 8360141 (1)
hematoxylin	25.80	5	16681682 (1), 15043314 (1), 15832080 (1), 17069678 (1)
fatty acid	22.98	14	15599942 (2), 11356171 (1), 11956072 (1), 15632186 (1) (see all 11)
methionine	20.19	2	8011166 (1), 7753485 (1)
sterol	7.28	5	18577977 (1), 9803880 (1)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (AMACR)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (AMACR)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_014324

Sigma-Aldrich siRNA and siRNA Panels for AMACR

Sigma-Aldrich shRNA for AMACR

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_014324 NM_203382

REFSEQ mRNAs for AMACR gene (2 alternative transcripts):

NM_014324.4 NM_203382.1

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_014324 NM_203382

               OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_014324
                                 Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_014324
                                 untagged cDNA clones in CMV expression vector (see all 2): NM_014324

Additional cDNA sequence:

AF047020.1 AF158378.1 AJ130733.1 AK000912.1 AK022765.1 AK222831.1 AK225749.1 AK292988.1

AY330488.1 AY330489.1 AY935981.1 BC009471.1 BT007193.1 CR615811.1 CR616479.1 CR618063.1

CR625004.1 EF560721.1 FJ498906.1 FJ498907.1 FJ498908.1

9 DOTS entries:

DT.309182 DT.92449921 DT.101973657 DT.92449924 DT.97770152 DT.92449923 DT.308935 DT.455566

DT.92009684

24/212 AceView cDNA sequences (see all 212 ):

BU071196 AI559314 AI215841 AW293739 BF196011 AW473991 NM_203382 CR615811

BQ009670 NM_014324 BF858148 AI468850 AI521218 AI369058 AI538685 AW338481

AA534857 AW140056 CR625004 BM987815 AA888589 BE670233 AL119905 BF858182

highest scoring ESTs for AMACR:

AJ130733 AF047020 AF158378 AK000912 AK022765 AL545355 AL558977 AL710886 AU098922 AU117376

Unigene Cluster for AMACR:

Alpha-methylacyl-CoA racemase

Hs.508343 [show with all ESTs]

Unigene Representative Sequence: CR616479

GeneLoc Exon Structure

5/8 Alternative Splicing Database (ASD) splice patterns (SP) for AMACR (see all 8 )

ExUns:	1a	·	1b	·	1c	·	1d	·	1e	^	2a	·	2b	^	3a	·	3b	^	4a	·	4b	·	4c	^	5a	·	5b	·	5c	·	5d	^	6a	·	6b	·	6c	^	7a	·	7b
SP1:																									-		-		-		-
SP2:																									-		-		-		-
SP3:
SP4:																									-
SP5:																			-						-		-		-		-

About this scheme

ECgene alternative splicing isoforms for AMACR

8 Ensembl transcripts including schematic representations:

ENST00000382056 ENST00000382065 ENST00000382079 ENST00000231338 ENST00000382068 ENST00000382072

ENST00000335606 ENST00000382085

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

AMACR expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for AMACR

¹ / ² / ³

11 probe-sets matching AMACR gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
83041_at²^{, 3}	U95-D	1	1.00	1.00	0.89	1.10	AI557599	0.60	1.00	0.82	1
90077_at²^{, 3}	U95-E	1	1.00	1.00	0.99	1.09	AA888589	0.60	0.83	0.73	1
41706_at²^{, 3}	U95-A	1	1.00	1.00	0.97	0.82	AJ130733	1.00	0.90	0.95	1
209426_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	AF047020	0.80	0.88	0.84	1
209424_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	AI796120	0.60	0.83	0.73	1
217111_at²^{, 3}	U133-A	1	1.00	1.00	--	--	AK022765	0.80	0.88	0.84	1
209425_at²^{, 3}	U133-A	1	0.91	1.00	--	--	AA888589	0.60	0.83	0.73	1
209426_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
209424_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
217111_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
209425_at²	U133Plus2	1	0.91	1.00	--	--	--	--	--	--	--

GeneDecks AMACR for binary patterns associated with the probe-sets selected above

About GeneDecksing

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Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: --

SOURCE GeneReport for Unigene cluster: Hs.508343
Expression variation in blood from EXPOLDB for AMACR

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for AMACR gene from 5/15 species (see all 15 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	AMACR¹	--	alpha-methylacyl-CoA racemase	84.03(n) 80.37(a)	612603 XM_850336.1 XP_855429.1
chimpanzee (Pan troglodytes)	AMACR¹	--	alpha-methylacyl-CoA racemase	99.04(n) 97.91(a)	461953 XM_001152698.1 XP_001152698.1
cow (Bos taurus)	AMACR¹	--	alpha-methylacyl-CoA racemase	83.94(n) 84.29(a)	540376 XM_593629.3 XP_593629.3
rat (Rattus norvegicus)	Amacr¹	--	alpha-methylacyl-CoA racemase	80.33(n) 78.12(a)	25284 NM_012816.1 NP_036948.1
mouse (Mus musculus)	Amacr^{1, 5}	15⁵	alpha-methylacyl-CoA racemase^{1, 5}	79.7(n)¹ 77.43(a)¹	17117¹ NM_008537.4¹ NP_032563.2¹ AK002401⁵ AK048249⁵ (see all 9)

About this table Species with no ortholog for AMACR

ENSEMBL Gene Tree for AMACR

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for AMACR gene

C7orf10²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/145 NCBI SNPs in AMACR are shown (see all 145 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 95)

AB	SNP ID	Valid	Chr 5 pos	Sequence	Recs	AA Chg	Type	More	Recs	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--			--
	rs2278008^1,2	A,C,F,H,O	34025275(+)	`CTTCTC/TTGCAA`	2	E/K	mis¹ ut3¹ ese³		19	EA MN CSAM NA EU WA	3102
	rs10077475^1,2	A,C,F,H	34044766(+)	`AGAGAT/CATGCC`	2	--	ng3¹		7	EU EA WA NA	538
	rs3195676^1,2	A,C,F,H	34043857(-)	`CGGTCG/ATGGAG`	2	M/V	mis¹ ese³		20	MN EA EU WA NA CSAM	3028
	rs2287939^1,2	A,C,F,H	34034640(-)	`GAAATC/TGAGTC`	2	L/S I/I	mis¹ syn¹		17	MN CSAM EA EU WA NA	1592
	rs6863560^1,2	A,C,F,H	34024728(+)	`TAACTA/CCCATA`	2	--	ut3¹		7	EU EA WA NA	560
	rs12659370^1,2	A,C,F,H	34024338(+)	`CTGGAC/ATCTAC`	2	--	ut3¹ ese³		4	EU EA WA	420
	rs15612^1,2	C,F,H,O	34024292(+)	`GGCCCC/TGAGTT`	2	--	ut3¹ ese³		13	MN EU EA WA NA	1352
	rs10941112^1,2	A,C,F,H	34040464(-)	`CACTGG/ACAAGG`	2	D/G	mis¹ int¹ ese³		13	EU EA WA MN CSAM	1234
	rs16892064^1,2	C,F,H	34023885(+)	`CTTGCG/AATTGT`	2	--	ut3¹ ese³		12	NA EU EA WA	1052
	rs16892150^1,2	C,F,H	34041656(+)	`CTAACC/TGGCAG`	2	R/Q	mis¹ ese³		11	NA EU EA WA	962

About this table

HapMap Linkage Disequilibrium images for AMACR (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 604489

UniProtKB/Swiss-Prot: AMACR_HUMAN, Q9UHK6

Defects in AMACR are the cause of alpha-methylacyl-CoA racemase deficiency (AMACRD)

[MIM:604489]. AMACRD results in elevated plasma concentrations of pristanic acid C27-bile-acid

intermediates. It can be associated with polyneuropathy, retinitis pigmentosa, epilepsy

Defects in AMACR are the cause of congenital bile acid synthesis defect type 4 (CBAS4)

[MIM:214950]; also known as cholestasis, intrahepatic, with defective conversion of

trihydroxycoprostanic acid to cholic acid or trihydroxycoprostanic acid in bile. Clinical features

include neonatal jaundice, intrahepatic cholestasis, bile duct deficiency and absence of cholic

acid from bile

10/64 Novoseek disease relationships for AMACR gene (see all 64 )

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
prostatic intraepithelial neoplasia	78.47	24	18343427 (6), 15602744 (2), 11926890 (1), 15297968 (1) (see all 13)
prostatic adenocarcinoma	70.92	46	16938524 (4), 15330799 (4), 12893336 (3), 15743746 (3) (see all 21)
prostate cancer	70.54	300	15941951 (10), 15173267 (8), 11926890 (8), 11956072 (7) (see all 85)
prostate carcinoma	65.46	40	15743746 (3), 17134736 (3), 17527076 (3), 16932031 (3) (see all 23)
carcinoma spindle cell	51.06	2	16330937 (2)
adenocarcinoma	48.58	46	15958853 (5), 15725808 (3), 14739905 (3), 17550379 (2) (see all 23)
oncocytoma	47.58	6	14707866 (1), 15858144 (1), 16166433 (1), 18036175 (1)
zellweger syndrome	47.45	4	11160375 (1), 18577977 (1)
refsum disease	46.10	2	17956237 (1)
carcinoma	45.19	34	15941950 (5), 17550379 (3), 17652945 (3), 17008281 (3) (see all 19)

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Genatlas disease: AMACR

sensory motor neuropathy adult onset may be associated with a retinitis pigmentosa,associated with

elevated plasma concentrations of pristanic acid and C27-bile-acid intermediates

Human Gene Mutation Database: AMACR
Genetic Association Database: AMACR
Human Genome Epidemiology Navigator: AMACR (6 documents)

(Possibly Related Articles in Doctor's Guide)
About This Section

Novel Tissue Biomarker Can Predict Prostate Cancer Progression: Presented at CURy

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/301 PubMed articles for AMACR gene (see all 301 ):

Mutations in the gene encoding peroxisomal alpha-methylacyl-CoA racemase cause adult-onset sensory motor neuropathy. (PubMed id 10655068)^{1, 3, 4} Ferdinandusse S....Wanders R.J.A. (2000)
Sequence variants of alpha-methylacyl-CoA racemase are associated with prostate cancer risk. (PubMed id 12438241)^{3, 6} Zheng S.L....Xu J. (2002)
Mitochondrial and peroxisomal targeting of 2-methylacyl-CoA racemase in humans. (PubMed id 11060344)^{3, 4} Amery L.... Van Veldhoven P.P. (2000)
Molecular cloning of cDNA species for rat and mouse liver alpha-methylacyl-CoA racemases. (PubMed id 9307041)^{2, 3} Schmitz W....Conzelmann E. (1997)
Purification and characterization of an alpha-methylacyl-CoA racemase from human liver. (PubMed id 7649182)^{3, 4} Schmitz W.... Conzelmann E. (1995)
Deletion hotspots in AMACR promoter CpG island are cis-regulatory elements controlling the gene expression in the colon. (PubMed id 19148275)^{1, 3} Zhang X....Ho S.M. (2009)
alpha-Methylacyl coenzyme A racemase as a tissue biomarker for prostate cancer. (PubMed id 11926890)^{1, 3} Rubin M.A....Chinnaiyan A.M. (2002)
alpha-Methylacyl-CoA racemase: expression levels of this novel cancer biomarker depend on tumor differentiation. (PubMed id 12213712)^{1, 3} Kuefer R....Rubin M.A. (2002)
The prostate-specific G-protein coupled receptors PSGR and PSGR2 are prostate cancer biomarkers that are complementary to alpha-methylacyl-CoA racemase. (PubMed id 16491480)^{1, 3} Wang J....Ittmann M. (2006)
Decreased alpha-methylacyl CoA racemase expression in localized prostate cancer is associated with an increased rate of biochemical recurrence and cancer-specific death. (PubMed id 15941951)^{1, 3} Rubin M.A....Johansson J.E. (2005)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 23600	HGNC: 451	AceView: AMACR	Ensembl:ENSG00000082196	euGenes: HUgn23600
ECgene: AMACR	H-InvDB: AMACR

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
ATLAS Chromosomes in Cancer entry for AMACR	Genetics and Cytogenetics in Oncology and Haematology
GeneReviews	http://www.genetests.org/query?gene=AMACR

Licensable Technologies for AMACR
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for AMACR:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for AMACR-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for AMACR		Antibodies for AMACR
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for AMACR		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Recombinant Proteins (AMACR)
	Antibodies (AMACR)
	Chimera RNAi (AMACR)
	Custom Service for Mouse Mab
	Custom Service for Rabbit Pab from Full-length Protein

Antibodies & Assays for AMACR

	Recombinant Proteins (AMACR + p63, AMACR)
	Antibodies (AMACR + p63, AMACR)

Search OriGene for AMACR

Search Tocris compounds for AMACR

Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Antibodies for AMACR

GeneCards Homepage - Last full update: 2 Jul 2009 Incremental update: 13 Oct 2009

Random Gene From GIFtS :

about GIFtS

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Developed at the Crown Human Genome Center & Weizmann Institute of Science

The GeneCards Human Gene Database: Copyright © 1996-2009, Weizmann Institute of Science. All Rights Reserved.
AMACR Gene at Home site.
Version 2.41.1
server5.xennexinc.com

AMACR Gene

protein-coding GIFtS: 66

Aliases &
Descriptions
for AMACR

Summaries
for AMACR

Genomic Location
for AMACR

Proteins
for AMACR

Protein Domains/
Families
for AMACR

Gene Function
for AMACR

Pathways & Interactions
for AMACR

Drugs & Compounds
for AMACR

Transcripts
for AMACR

Expression
for AMACR

Orthologs
for AMACR

Paralogs
for AMACR

SNPs/Variants
for AMACR

Disorders & Mutations
for AMACR

Medical News
for AMACR

Publications
for AMACR

Search for AMACR

Genome Databases showing AMACR

Other Databases showing AMACR

Specialized Databases showing AMACR

Licensable Technologies
for AMACR

Services
for AMACR

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

AMACR Gene

protein-coding GIFtS: 66

Aliases & Descriptionsfor AMACR

Summariesfor AMACR

Genomic Locationfor AMACR

Proteinsfor AMACR

Protein Domains/Familiesfor AMACR

Gene Functionfor AMACR

Pathways & Interactionsfor AMACR

Drugs & Compoundsfor AMACR

Transcriptsfor AMACR

Expression for AMACR

Orthologsfor AMACR

Paralogsfor AMACR

SNPs/Variantsfor AMACR

Disorders & Mutationsfor AMACR

Medical Newsfor AMACR

Publicationsfor AMACR

Search for AMACR

Genome Databases showing AMACR

Other Databases showing AMACR

Specialized Databases showing AMACR

Licensable Technologiesfor AMACR

Servicesfor AMACR

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for AMACR

Summaries
for AMACR

Genomic Location
for AMACR

Proteins
for AMACR

Protein Domains/
Families
for AMACR

Gene Function
for AMACR

Pathways & Interactions
for AMACR

Drugs & Compounds
for AMACR

Transcripts
for AMACR

Expression
for AMACR

Orthologs
for AMACR

Paralogs
for AMACR

SNPs/Variants
for AMACR

Disorders & Mutations
for AMACR

Medical News
for AMACR

Publications
for AMACR

Licensable Technologies
for AMACR

Services
for AMACR