ALYREF Gene
protein-coding GIFtS: 53
GCID: GC17M079849
|
|
Aly/REF export factor(Previous name: THO complex 4 )
(Previous symbol: THOC4)
| |
Aliases
for ALYREF gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Aly/REF Export Factor1 2 3 | | Ally Of AML-1 And LEF-12 3 | | ALY1 2 3 5 | | Transcriptional Coactivator Aly/REF2 3 | | BEF1 2 3 5 | | BZIP-Enhancing Factor BEF2 3 | | THOC41 2 3 5 | | BZIP Enhancing Factor2 | | ALY/REF1 2 | | THO Complex Subunit 42 | | REF1 2 | | Tho43 | | THO Complex 41 2 | | Tho43 |
Export aliases for ALYREF gene to outside databasesPrevious GC identifer: GC17M079846 |
Summaries
for ALYREF gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for ALYREF:
The protein encoded by this gene is a heat stable, nuclear protein and functions as a molecular chaperone. It isthought to regulate dimerization, DNA binding, and transcriptional activity of basic region-leucine zipper (bZIP)proteins. (provided by RefSeq, Jul 2008)
UniProtKB/Swiss-Prot: THOC4_HUMAN, Q86V81Function: Component of the THO subcomplex of the TREX complex. The TREX complex specifically associates with splicedmRNA and not with unspliced pre-mRNA. It is recruited to spliced mRNAs by a transcription-independent mechanism. Bindsto mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to aregion near the 5' end of the mRNA where it functions in mRNA export. The recruitment occurs via an interactionbetween ALYREF/THOC4 and the cap-binding protein NCBP1. DDX39B functions as a bridge between ALYREF/THOC4 and the THOcomplex. ALYREF/THOC4 in conjunction with THOC5 functions in NXF1-NXT1 mediated nuclear export of HSP70 mRNAFunction: Component of a splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junction onmRNAs. The EJC is a dynamic structure consisting of a few core proteins and several more peripheral nuclear andcytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequentmRNA metabolism. Acts as chaperone and promotes the dimerization of transcription factors containing basic leucinezipper (bZIP) domains and thereby promotes transcriptional activation. Plays a role in mRNA processing and export. Mayfunction as scaffold that mediates interactions between proteins and/or RNA. Is part of the exon junction complex thatremains associated with spliced mRNA and plays an important role in mRNA export and nonsense-mediated RNA decay
Gene Wiki entry for ALYREF (THOC4)
|
Genomic Views
for ALYREF gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000017.10 NC_018928.1 NT_010663.15
Regulatory elements:
 Search SABiosciences Regulatory transcription factor binding sites for ALYREF
Other transcription factors
Search SABiosciences Chromatin IP Primers for ALYREF
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ALYREF |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 17q25.3 Ensembl cytogenetic band: 17q25.3 HGNC cytogenetic band: 17q25.3ALYREF Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 17 GeneLoc Exon Structure GeneLoc location for GC17M079849: view genomic region
(about GC identifiers)
Start:
|
79,845,711 bp from pter |
End:
|
79,849,462 bp from pter |
Size:
|
3,752 bases |
Orientation:
|
minus strand |
|
Proteins
for ALYREF gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: THOC4_HUMAN, Q86V81 (See
protein sequence)Recommended Name: THO complex subunit 4 Size: 257 amino acids; 26888 Da
Subunit: Homomultimer. Component of the THO complex, which is composed of THOC1, THOC2, THOC5, THOC6 and THOC7.Together with THOC3, ALYREF/THOC4 and DDX39B, THO forms the transcription/export (TREX) complex. Interacts (viaC-terminus) with DDX39B. Interacts with NCBP1 and THOC5. Binds LEF1 and RUNX1 (By similarity). Is part of severalcomplexes involved in mRNA processing and export. Associates with the spliceosome. Binds NXF1 and RBM8A directly andis part of the exon junction complex (EJC) containing NCBP1, NCBP2, RBM8A, RNPS1, SRRM1, NXF1, UPF2, UPF3B,ALYREF/THOC4 and/or REFBP2 (By similarity). Found in a mRNA splicing-dependent exon junction complex (EJC) with ACIN1,CASC3, DEK, EIF4A3, MAGOH, PNN, RBM8A, RNPS1, SAP18, SRRM1 and ALYREF/THOC4. Found in a mRNP complex with UPF3A andUPF3B. Interacts with BAT1, EIF4A3, RBM8A, RNPS1 and SRRM1. Identified in the spliceosome C complex. Interacts withhuman Kaposi's sarcoma-associated herpesvirus (HHV-8) ORF57 protein; this interaction allows efficient export of HHV-8early and late intronless transcripts. Interacts with HHV-1 ICP27 protein; this interaction recruits ALYREF to viralreplication compartments and probably directs viral mRNA to the TAP/NFX1 pathway
Subcellular location: Nucleus. Nucleus speckle. Cytoplasm. Note=Colocalizes with the core EJC, ALYREF/THOC4, NXF1 andDDX39B in the nucleus and nuclear speckles. Travels to the cytoplasm as part of the exon junction complex (EJC) boundto mRNA
Miscellaneous: Antibodies against ALYREF/THOC4 are found in sera of patients with systemic lupus erythematosus (SLE)
1 PDB 3D structure from  and Proteopedia  for ALYREF:3ULH (3D)
Secondary accessions: O43672Explore the universe of human proteins at neXtProt for ALYREF: NX_Q86V81
Post-translational modifications:
Arg-50 and Arg-204 are dimethylated, probably to asymmetric dimethylarginine1
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q86V81
ALYREF Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_005773.3
ENSEMBL proteins: ENSP00000421592 ENSP00000331817 Reactome Protein details: Q86V81
Human Recombinant Protein Products:
Gene Ontology (GO): 5/7 cellular component terms (GO ID links to tree view) (see all 7): About this table
ALYREF for ontologies About GeneDecksing
ALYREF Antibody Products:
Assay Products for ALYREF: |
Protein
Domains /
Families
for ALYREF gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
ALYREF for domains About GeneDecksing
3 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q86V81ProtoNet protein and cluster: Q86V81 1 Blocks protein family: IPB000504 RNA-binding region RNP-1 (RNA recognition motif)
UniProtKB/Swiss-Prot: THOC4_HUMAN, Q86V81Similarity: Belongs to the ALYREF familySimilarity: Contains 1 RRM (RNA recognition motif) domain |
Function
for ALYREF gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: THOC4_HUMAN, Q86V81Function: Component of the THO subcomplex of the TREX complex. The TREX complex specifically associates with splicedmRNA and not with unspliced pre-mRNA. It is recruited to spliced mRNAs by a transcription-independent mechanism. Bindsto mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to aregion near the 5' end of the mRNA where it functions in mRNA export. The recruitment occurs via an interactionbetween ALYREF/THOC4 and the cap-binding protein NCBP1. DDX39B functions as a bridge between ALYREF/THOC4 and the THOcomplex. ALYREF/THOC4 in conjunction with THOC5 functions in NXF1-NXT1 mediated nuclear export of HSP70 mRNAFunction: Component of a splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junction onmRNAs. The EJC is a dynamic structure consisting of a few core proteins and several more peripheral nuclear andcytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequentmRNA metabolism. Acts as chaperone and promotes the dimerization of transcription factors containing basic leucinezipper (bZIP) domains and thereby promotes transcriptional activation. Plays a role in mRNA processing and export. Mayfunction as scaffold that mediates interactions between proteins and/or RNA. Is part of the exon junction complex thatremains associated with spliced mRNA and plays an important role in mRNA export and nonsense-mediated RNA decay
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ALYREF (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ALYREF (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript Custom all cDNA clones Services for ALYREF | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ALYREF | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ALYREF |
Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view): About this table
ALYREF for ontologies About GeneDecksing
2 GenomeRNAi human phenotypes for ALYREF:
|
Pathways & Interactions
for ALYREF gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways - 5/10 super-pathways (see all 10) About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | RNA Polymerase II Transcription Termination | | | 2 | mRNA Splicing - Major Pathway | | | 3 | Transport of the SLBP independent Mature mRNA | | | 4 | Transport of Mature mRNA Derived from an Intronless Transcript | | | 5 | Transcription | |
Pathway sources
See GeneCards unified pathways
Show all pathways
1 
Cell Signaling Technology (CST) Pathway for ALYREF
5/18 
Reactome Pathways for ALYREF (see all 18)
3 
Kegg Pathways (Kegg details for ALYREF):
ALYREF for pathways About GeneDecksing
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ALYREF
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/213 Interacting proteins for ALYREF (Q86V812, 3 ENSP000003318174) via UniProtKB, MINT, STRING, and/or I2D (see all 213)About this table
Gene Ontology (GO): 5/8 biological process terms (GO ID links to tree view) (see all 8): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0000398 | mRNA splicing, via spliceosome |
TAS | -- | | GO:0006366 | transcription from RNA polymerase II promoter |
TAS | -- | | GO:0006369 | termination of RNA polymerase II transcription |
TAS | -- | | GO:0006406 | mRNA export from nucleus |
TAS | -- | | GO:0008380 | RNA splicing |
TAS | -- |
ALYREF for ontologies About GeneDecksing
|
Drugs & Compounds
for ALYREF gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for ALYREF
Search CenterWatch for drugs/clinical trials and news about ALYREF / THOC4
|
Transcripts
for ALYREF gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for ALYREF gene: NM_005782.3 Unigene Cluster for ALYREF: Aly/REF export factor Hs.534385 [show with all ESTs]Unigene Representative Sequence: BU9438615 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000505490 ENST00000504015 ENST00000512673 ENST00000511412 ENST00000331204(uc002kbu.2)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ALYREF (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ALYREF (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript Custom all cDNA clones Services for ALYREF | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ALYREF | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ALYREF |
Additional cDNA sequence: AF047002.1 AF086513.1 BC052302.1 8 DOTS entries: DT.95304701 DT.113574 DT.100738694 DT.86849160 DT.92056696 DT.95158694 DT.100826159 DT.95158693 24/123 AceView cDNA sequences (see all 123): AI088790 AI243940 BM766572 BM854462 AI299722 BM784649 BU538782 AI343405 BM782350 AI423863 AF086513 AI283498 BM782652 BU624466 AI206071 BQ919512 AI824093 BF512771 AI809223 AI934760 AW082296 AI085289 BF446070 BU957767
GeneLoc Exon Structure
3 Alternative Splicing Database (ASD) splice patterns (SP) for ALYREF About this scheme
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6a | · | 6b | ^ | 7a | · | 7b |
|---|
|
| SP1: | | | | | | | | | - | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | - | | | | - | | | | | | | |
ECgene alternative splicing isoforms for ALYREF
|
Expression
for ALYREF gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| ALYREF expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TAAAGGTTTT
About this image
See ALYREF Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for ALYREF
SOURCE GeneReport for Unigene cluster: Hs.534385
SABiosciences Custom PCR Arrays for ALYREF
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ALYREF
Browse OriGene validated miRNA SYBR primer pairs
| | | Search SABiosciences RT2 qPCR
Primer Assays in human, mouse, rat ALYREF | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ALYREF | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ALYREF |
Orthologs
for ALYREF gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for ALYREF gene from 9/29 species (see all 29) About this table
ENSEMBL Gene Tree for ALYREF (if available)
TreeFam Gene Tree for ALYREF (if available) |
Paralogs
for ALYREF gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for ALYREF gene
ALYREF for paralogs About GeneDecksing
2 Pseudogenes.org Pseudogenes for ALYREF
PGOHUM00000233434 PGOHUM00000262546
|
Genomic Variants
for ALYREF gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 17 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for ALYREF (79845711 - 79849462 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for ALYREF: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ALYREF |
|
Disorders
/ Diseases
for ALYREF gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
ALYREF for disorders About GeneDecksing
OMIM gene information: 604171
OMIM disorders: --
11  diseases for ALYREF: About MalaCardsmetastasis efficiency systemic lupus erythematosus lupus erythematosus herpes simplex
kaposi's sarcoma hermaphroditism conjunctivitis sarcoma
hepatocellular carcinoma breast cancer carcinoma
Export disorders for ALYREF gene to outside databases
|
Publications
for ALYREF gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for ALYREF gene, integrated from 9 sources (see all 81):
(articles sorted by number of sources associating them with ALYREF) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Autoantibodies to transcriptional regulation proteins DEK and ALY in a patient with systemic lupus erythematosus. (PubMed id 9952027)1, 2, 9 Wichmann I.... Nunez-Roldan A. (1999)
- A human nuclear-localized chaperone that regulates dimerization, DNA binding, and transcriptional activity of bZIP proteins. (PubMed id 10488337)1, 2, 9 Virbasius C.-M.... Green M.R. (1999)
- Recruitment of the complete hTREX complex is required for Kaposi's sarcoma-associated herpesvirus intronless mRNA nuclear export and virus replication. (PubMed id 18974867)1, 2, 9 Boyne J.R.... Whitehouse A. (2008)
- Adaptor Aly and co-adaptor Thoc5 function in the Tap-p15-mediated nuclear export of HSP70 mRNA. (PubMed id 19165146)1, 2 Katahira J.... Yoneda Y. (2009)
- Human mRNA export machinery recruited to the 5' end of mRNA. (PubMed id 17190602)1, 2 Cheng H.... Reed R. (2006)
- Linking transcriptional elongation and messenger RNA export to metastatic breast cancers. (PubMed id 15833825)1, 2 Guo S.... Shiekhattar R. (2005)
- Recruitment of the human TREX complex to mRNA during splicing. (PubMed id 15998806)1, 2 Masuda S.... Reed R. (2005)
- Identifying and quantifying in vivo methylation sites by heavy methyl SILAC. (PubMed id 15782174)1, 2 Ong S.E.... Mann M. (2004)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- An evolutionarily conserved role for SRm160 in 3'-end processing that functions independently of exon junction complex formation. (PubMed id 12944400)1, 2 McCracken S.... Blencowe B.J. (2003)
|
External Searches for ALYREF gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing ALYREF gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing ALYREF gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing ALYREF gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for ALYREF | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for ALYREF gene:
Search GeneIP for patents involving ALYREF
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for ALYREF gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | OriGene Antibodies for ALYREF | | OriGene shRNA RFP for ALYREF | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ALYREF | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ALYREF | | | OriGene Protein Over-expression Lysate for ALYREF | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for ALYREF | | OriGene 3'-UTR Clone for ALYREF | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ALYREF | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ALYREF | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for ALYREF | | OriGene Custom Protein Services for ALYREF | | | OriGene Custom Immunoassay Development | | |
| |
 |
 |
| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat ALYREF | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ALYREF | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ALYREF | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ALYREF | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ALYREF | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ALYREF |
| |
 |  |  |  | |
| | Antibodies & Assays for ALYREF (THOC4) |
| | | | Search Tocris compounds for ALYREF |
| |  |  |  |  | | | | |
 |
 |
 |
 | | | ALYREF Proteins, Antibodies, CLIAs, and ELISAs |
| | | |  |  |  | | | | ThermoFisher Antibody for ALYREF |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ALYREF |
|
|
|
|
