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Aliases for ALX3 Gene

Aliases for ALX3 Gene

  • ALX Homeobox 3 2 3
  • Proline-Rich Transcription Factor ALX3 3 4
  • Aristaless-Like Homeobox 3 2 3
  • Frontonasal Dysplasia 2 3
  • FND1 3 6
  • Homeobox Protein Aristaless-Like 3 3
  • FND 3

External Ids for ALX3 Gene

Previous HGNC Symbols for ALX3 Gene

  • FND

Previous GeneCards Identifiers for ALX3 Gene

  • GC01M111018
  • GC01M109469
  • GC01M109704
  • GC01M109901
  • GC01M110314
  • GC01M110404
  • GC01M110602
  • GC01M108472

Summaries for ALX3 Gene

Entrez Gene Summary for ALX3 Gene

  • This gene encodes a nuclear protein with a homeobox DNA-binding domain that functions as a transcriptional regulator involved in cell-type differentiation and development. Preferential methylation of this gene's promoter is associated with advanced-stage neuroblastoma tumors. [provided by RefSeq, Jul 2008]

GeneCards Summary for ALX3 Gene

ALX3 (ALX Homeobox 3) is a Protein Coding gene. Diseases associated with ALX3 include frontonasal dysplasia 1 and basal encephalocele. GO annotations related to this gene include sequence-specific DNA binding transcription factor activity and sequence-specific DNA binding. An important paralog of this gene is PHOX2B.

UniProtKB/Swiss-Prot for ALX3 Gene

  • Transcriptional regulator with a possible role in patterning of mesoderm during development.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ALX3 Gene

Genomics for ALX3 Gene

Regulatory Elements for ALX3 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for ALX3 Gene

110,059,994 bp from pter
110,070,700 bp from pter
10,707 bases
Minus strand

Genomic View for ALX3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ALX3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ALX3 Gene

Proteins for ALX3 Gene

  • Protein details for ALX3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Homeobox protein aristaless-like 3
    Protein Accession:
    Secondary Accessions:
    • O95075
    • Q5T8M4

    Protein attributes for ALX3 Gene

    343 amino acids
    Molecular mass:
    36935 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ALX3 Gene

Proteomics data for ALX3 Gene at MOPED

Post-translational modifications for ALX3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ALX3 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for ALX3 Gene

Domains for ALX3 Gene

Gene Families for ALX3 Gene

Protein Domains for ALX3 Gene

Suggested Antigen Peptide Sequences for ALX3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 homeobox DNA-binding domain.
  • Belongs to the paired homeobox family.
  • Contains 1 homeobox DNA-binding domain.
  • Belongs to the paired homeobox family.
genes like me logo Genes that share domains with ALX3: view

Function for ALX3 Gene

Molecular function for ALX3 Gene

UniProtKB/Swiss-Prot Function:
Transcriptional regulator with a possible role in patterning of mesoderm during development.

Gene Ontology (GO) - Molecular Function for ALX3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding --
GO:0043565 sequence-specific DNA binding IEA --
genes like me logo Genes that share ontologies with ALX3: view
genes like me logo Genes that share phenotypes with ALX3: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for ALX3 Gene

Localization for ALX3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ALX3 Gene

Subcellular locations from

Jensen Localization Image for ALX3 Gene COMPARTMENTS Subcellular localization image for ALX3 gene
Compartment Confidence
nucleus 3

Gene Ontology (GO) - Cellular Components for ALX3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ALX3: view

Pathways for ALX3 Gene

SuperPathways for ALX3 Gene

No Data Available

Interacting Proteins for ALX3 Gene

Gene Ontology (GO) - Biological Process for ALX3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0007389 pattern specification process IEA --
GO:0035115 embryonic forelimb morphogenesis IEA --
GO:0035116 embryonic hindlimb morphogenesis IEA --
genes like me logo Genes that share ontologies with ALX3: view

No data available for Pathways by source for ALX3 Gene

Transcripts for ALX3 Gene

mRNA/cDNA for ALX3 Gene

(1) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(3) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ALX3 Gene

ALX homeobox 3:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ALX3

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ALX3 Gene

No ASD Table

Relevant External Links for ALX3 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ALX3 Gene

mRNA expression in normal human tissues for ALX3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

SOURCE GeneReport for Unigene cluster for ALX3 Gene Hs.669953

genes like me logo Genes that share expressions with ALX3: view

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Expression partners for ALX3 Gene

Orthologs for ALX3 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ALX3 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia ALX3 35
  • 90.96 (n)
  • 91.25 (a)
ALX3 36
  • 91 (a)
(Canis familiaris)
Mammalia ALX3 35
  • 87.09 (n)
  • 84.96 (a)
ALX3 36
  • 87 (a)
(Mus musculus)
Mammalia Alx3 35
  • 88.82 (n)
  • 91.84 (a)
Alx3 16
Alx3 36
  • 92 (a)
(Pan troglodytes)
Mammalia ALX3 35
  • 99.32 (n)
  • 99.71 (a)
ALX3 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Alx3 35
  • 88.44 (n)
  • 90.96 (a)
(Monodelphis domestica)
Mammalia ALX3 36
  • 79 (a)
(Ornithorhynchus anatinus)
Mammalia ALX3 36
  • 67 (a)
(Gallus gallus)
Aves ALX3 35
  • 74.18 (n)
  • 71.43 (a)
ALX3 36
  • 66 (a)
(Danio rerio)
Actinopterygii LOC566955 35
  • 62.29 (n)
  • 59.46 (a)
BX324132.5 36
  • 45 (a)
Species with no ortholog for ALX3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ALX3 Gene

Gene Tree for ALX3 (if available)
Gene Tree for ALX3 (if available)

Paralogs for ALX3 Gene

Paralogs for ALX3 Gene

(2) SIMAP similar genes for ALX3 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with ALX3: view

Variants for ALX3 Gene

Sequence variations from dbSNP and Humsavar for ALX3 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs481420 -- 110,066,139(+) CTGGA(C/G)AAATG intron-variant
rs658381 -- 110,067,707(+) TCCTC(C/T)GGCCA intron-variant
rs677948 -- 110,063,144(+) TGCAC(C/T)CTCTC intron-variant
rs697384 -- 110,071,638(+) ATTCA(A/G)AAGGG upstream-variant-2KB
rs705279 -- 110,061,544(+) TGGCT(C/T)TGCGG missense, reference

Relevant External Links for ALX3 Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for ALX3 Gene

Disorders for ALX3 Gene

(1) OMIM Diseases for ALX3 Gene (606014)


  • Frontonasal dysplasia 1 (FND1) [MIM:136760]: The term frontonasal dysplasia describes an array of abnormalities affecting the eyes, forehead and nose and linked to midfacial dysraphia. The clinical picture is highly variable. Major findings include true ocular hypertelorism; broadening of the nasal root; median facial cleft affecting the nose and/or upper lip and palate; unilateral or bilateral clefting of the alae nasi; lack of formation of the nasal tip; anterior cranium bifidum occultum; a V-shaped or widows peak frontal hairline. {ECO:0000269 PubMed:19409524}. Note=The disease is caused by mutations affecting the gene represented in this entry.

(1) University of Copenhagen DISEASES for ALX3 Gene

Relevant External Links for ALX3

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with ALX3: view

No data available for Novoseek inferred disease relationships and Genatlas for ALX3 Gene

Publications for ALX3 Gene

  1. Combined restriction landmark genomic scanning and virtual genome scans identify a novel human homeobox gene, ALX3, that is hypermethylated in neuroblastoma. (PMID: 11807986) Wimmer K. … Hanash S.M. (Genes Chromosomes Cancer 2002) 2 3 4 23
  2. Frontorhiny, a distinctive presentation of frontonasal dysplasia caused by recessive mutations in the ALX3 homeobox gene. (PMID: 19409524) Twigg S.R.F. … Wilkie A.O.M. (Am. J. Hum. Genet. 2009) 2 3 4
  3. Maternal genes and facial clefts in offspring: a comprehensive search for genetic associations in two population-based cleft studies from Scandinavia. (PMID: 20634891) Jugessur A. … Murray J.C. (PLoS ONE 2010) 3 48
  4. The homeoprotein Alx3 contains discrete functional domains and exhibits cell-specific and selective monomeric binding and transactivation. (PMID: 15226305) PAcrez-Villamil B. … Vallejo M. (J. Biol. Chem. 2004) 2 3
  5. The homeoprotein Alx3 expressed in pancreatic beta-cells regulates insulin gene transcription by interacting with the basic helix-loop-helix protein E47. (PMID: 16825292) Mirasierra M. … Vallejo M. (Mol. Endocrinol. 2006) 3

Products for ALX3 Gene

Sources for ALX3 Gene

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