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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ALX3 Gene

protein-coding   GIFtS: 50
GCID: GC01M110602

ALX Homeobox 3

(Previous name: aristaless-like homeobox 3)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
ALX Homeobox 31 2
Aristaless-Like Homeobox 31 2
Proline-Rich Transcription Factor ALX32 3
FND12
Homeobox Protein Aristaless-Like 32

External Ids:    HGNC: 4491   Entrez Gene: 2572   Ensembl: ENSG000001561507   OMIM: 6060145   UniProtKB: O950763   

Export aliases for ALX3 gene to outside databases

Previous GC identifers: GC01M111018 GC01M109469 GC01M109704 GC01M109901 GC01M110314 GC01M110404 GC01M108472


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for ALX3 Gene:
This gene encodes a nuclear protein with a homeobox DNA-binding domain that functions as a transcriptional
regulator involved in cell-type differentiation and development. Preferential methylation of this gene's promoter
is associated with advanced-stage neuroblastoma tumors. (provided by RefSeq, Jul 2008)

GeneCards Summary for ALX3 Gene: 
ALX3 (ALX homeobox 3) is a protein-coding gene. Diseases associated with ALX3 include basal encephalocele, and frontonasal dysplasia. GO annotations related to this gene include sequence-specific DNA binding and sequence-specific DNA binding transcription factor activity. An important paralog of this gene is ALX1.

UniProtKB/Swiss-Prot: ALX3_HUMAN, O95076
Function: Transcriptional regulator with a possible role in patterning of mesoderm during development (By
similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NC_018912.2  NT_032977.9  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ALX3 gene promoter:
         p300   IRF-1   Nkx2-5   E47   CBF-A   CBF-B   CP1A   NF-Y   Pax-4a   CBF(2)   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidALX3 promoter sequence
   Search SABiosciences Chromatin IP Primers for ALX3

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ALX3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p13.3   Ensembl cytogenetic band:  1p13.3   HGNC cytogenetic band: 1p13.3

ALX3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ALX3 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M110602:  view genomic region     (about GC identifiers)

Start:
110,602,616 bp from pter      End:
110,613,322 bp from pter
Size:
10,707 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: ALX3_HUMAN, O95076 (See protein sequence)
Recommended Name: Homeobox protein aristaless-like 3  
Size: 343 amino acids; 36935 Da
Subcellular location: Nucleus (By similarity)
Secondary accessions: O95075 Q5T8M4

Explore the universe of human proteins at neXtProt for ALX3: NX_O95076

Explore proteomics data for ALX3 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_O95076

  • ALX3 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    ALX3 Protein Expression
    REFSEQ proteins: NP_006483.2  
    ENSEMBL proteins: 
     ENSP00000358807  

    Human Recombinant Protein Products for ALX3: 
    Browse Purified and Recombinant Proteins at EMD Millipore
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    Browse OriGene Protein Over-expression Lysates
    OriGene Custom MassSpec 
    OriGene Custom Protein Services for ALX3
    GenScript Custom Purified and Recombinant Proteins Services for ALX3
    Novus Biologicals ALX3 Protein
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for ALX3 

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--

    ALX3 for ontologies           About GeneDecksing



    ALX3 Antibody Products: 
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    Novus Biologicals ALX3 Antibodies
    Abcam antibodies for ALX3
    Cloud-Clone Corp. Antibodies for ALX3 
    Search ThermoFisher Antibodies for ALX3
    LSBio Antibodies in human, mouse, rat for ALX3 

    Assay Products for ALX3: 
    Browse Kits and Assays available from EMD Millipore
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    GenScript Custom Assay Services for ALX3
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    Cloud-Clone Corp. ELISAs for ALX3 
    Cloud-Clone Corp. CLIAs for ALX3


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    PRD: Homeoboxes / PRD class

    3 InterPro protein domains:
     IPR017970 Homeobox_CS
     IPR001356 Homeodomain
     IPR009057 Homeodomain-like

    Graphical View of Domain Structure for InterPro Entry O95076

    ProtoNet protein and cluster: O95076

    UniProtKB/Swiss-Prot: ALX3_HUMAN, O95076
    Similarity: Belongs to the paired homeobox family
    Similarity: Contains 1 homeobox DNA-binding domain


    ALX3 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ALX3_HUMAN, O95076
    Function: Transcriptional regulator with a possible role in patterning of mesoderm during development (By
    similarity)

         Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding ----
    GO:0003700sequence-specific DNA binding transcription factor activity IEA--
    GO:0043565sequence-specific DNA binding IEA--
         
    ALX3 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for ALX3:
     Decreased cilium length after  

         15 MGI mutant phenotypes (inferred from 1 allele(MGI details for Alx3):
     behavior/neurological  cellular  craniofacial  digestive/alimentary  embryogenesis 
     endocrine/exocrine gland  growth/size  homeostasis/metabolism  limbs/digits/tail  mortality/aging 
     nervous system  reproductive system  respiratory system  skeleton  vision/eye 

    ALX3 for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for ALX3 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for ALX3

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for ALX3 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for ALX3 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ALX3
    8/9 QIAGEN miScript miRNA Assays for microRNAs that regulate ALX3 (see all 9):
    hsa-miR-10b hsa-miR-4306 hsa-miR-650 hsa-miR-504 hsa-miR-10a hsa-miR-3667-5p hsa-miR-670 hsa-miR-185
    SwitchGear 3'UTR luciferase reporter plasmidALX3 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for ALX3
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ALX3

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for ALX3
    Sirion Biotech Customized adenovirus for overexpression of ALX3

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for ALX3 (see all 6)
    OriGene ORF clones in mouse, rat for ALX3
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: ALX3 (NM_006492)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ALX3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ALX3
    Sirion Biotech Customized lentivirus for stable overexpression of ALX3 
                         Customized lentivirus expression plasmids for stable overexpression of ALX3 

    Cell Line
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    GenScript Custom overexpressing Cell Line Services for ALX3
    Search LifeMap BioReagents cell lines for ALX3
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ALX3


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ALX3

    1 Interacting protein for ALX3 (O950763) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    JDP2Q8WYK23I2D: score=1 
    About this table

    Gene Ontology (GO): 5/7 biological process terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-dependent IEA--
    GO:0006355regulation of transcription, DNA-dependent ----
    GO:0007389pattern specification process IEA--
    GO:0035115embryonic forelimb morphogenesis IEA--
    GO:0035116embryonic hindlimb morphogenesis IEA--

    ALX3 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ALX3

    Search CenterWatch for drugs/clinical trials and news about ALX3

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for ALX3 gene: 
    NM_006492.2  

    Unigene Cluster for ALX3:

    ALX homeobox 3
    Hs.669953  [show with all ESTs]
    Unigene Representative Sequence: AF008203
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000369792(uc001dzb.3)
    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ALX3
    8/9 QIAGEN miScript miRNA Assays for microRNAs that regulate ALX3 (see all 9):
    hsa-miR-10b hsa-miR-4306 hsa-miR-650 hsa-miR-504 hsa-miR-10a hsa-miR-3667-5p hsa-miR-670 hsa-miR-185
    SwitchGear 3'UTR luciferase reporter plasmidALX3 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for ALX3
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ALX3
    Clone
    Products:
         
    OriGene clones in human, mouse for ALX3 (see all 6)
    OriGene ORF clones in mouse, rat for ALX3
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: ALX3 (NM_006492)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ALX3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ALX3
    Sirion Biotech Customized lentivirus for stable overexpression of ALX3 
                         Customized lentivirus expression plasmids for stable overexpression of ALX3 
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for ALX3
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat ALX3
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ALX3
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ALX3

    Additional mRNA sequence: 

    AF008203.1 BC112007.1 BC113428.1 

    4 DOTS entries:

    DT.310753  DT.121360898  DT.91657690  DT.121360894 

    3 AceView cDNA sequences:

    NM_006492 AF008203 CD622788 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ALX3 expression in normal human tissues (normalized intensities)      ALX3 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CAGTCATCTT
    ALX3 Expression
    About this image


    ALX3 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/16 selected tissues (see all 16) fully expand
     
     Limb (Muscoskeletal System)    fully expand to see all 2 entries
             Limb Muscle Progenitor Cells Forelimb Myotome
             limb/forelimb   
     
     Neural Tube (Nervous System)    fully expand to see all 2 entries
             Spinal Ventral Columns
     
     Neural Crest (Gastrulation Derivatives)    fully expand to see all 2 entries
             sensory organ/nose/process   
     
     Gut Tube (Gastrointestinal Tract)
             Foregut
     
     Nose (Sensory Organs)
             sensory organ/nose/process   

    See ALX3 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ALX3

    SOURCE GeneReport for Unigene cluster: Hs.669953
        SABiosciences Custom PCR Arrays for ALX3
    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for ALX3
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat ALX3
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ALX3
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ALX3
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ALX3

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for ALX3 gene from 3/10 species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Alx31 , 5 aristaless-like homeobox 31, 5 88.82(n)1
    91.84(a)1
      3 (46.83 cM)5
    116941  NM_007441.21  NP_031467.11 
     1075950315 
    chicken
    (Gallus gallus)
    Aves LOC1008595611 homeobox protein aristaless-like 3-like 67.82(n)
    61.9(a)
      100859561  XM_003642735.1  XP_003642783.1 
    zebrafish
    (Danio rerio)
    Actinopterygii LOC5669551 homeobox protein aristaless-like 3-like 62.14(n)
    58.91(a)
      566955  XM_690238.1  XP_695330.1 


    ENSEMBL Gene Tree for ALX3 (if available)
    TreeFam Gene Tree for ALX3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ALX3 gene
    ALX12  PHOX2B2  ARX2  RAX2  DRGX2  PRRX12  SHOX22  PHOX2A2  
    ALX42  ISX2  RAX22  SHOX2  OTP2  PRRX22  
    2 SIMAP similar genes for ALX3 using alignment to 1 protein entry:     ALX3_HUMAN:
    ALX1    ALX4

    ALX3 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/310 SNPs in ALX3 are shown (see all 310)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0632294
    Frontonasal dysplasia 1 (FND1)4--see VAR_0632292 N S mis40--------
    VAR_0632264
    Frontonasal dysplasia 1 (FND1)4--see VAR_0632262 L V mis40--------
    VAR_0632274
    Frontonasal dysplasia 1 (FND1)4--see VAR_0632272 R W mis40--------
    rs1219081701,2,4
    CFrontonasal dysplasia 1 (FND1)4 pathogenic1110680011(-) AGGCCC/TGGGTA 2 R W mis10--------
    rs572799631,2
    C--110605267(+) GTGTG-/TGAGTA 1 -- int10--------
    rs346548831,2
    C--110605268(+) GTGTG-/G/TC  
            
    AGTAA
    1 -- int10--------
    rs1444726071,2
    --110675299(+) AACACC/TACCAC 1 -- ds50010--------
    rs1926567411,2
    --110675479(+) GGCTGA/GTCCCG 1 -- ds50010--------
    rs412813601,2
    C,F--110675667(+) CAGACA/GCCAGT 1 -- ds50012Minor allele frequency- G:0.15WA 120
    rs1155414621,2
    C,F--110675674(+) CAGTGC/TGCCCC 1 -- ds50011Minor allele frequency- T:0.01WA 118

    HapMap Linkage Disequilibrium report for ALX3 (110602616 - 110613322 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for ALX3: --

    Human Gene Mutation Database (HGMD): ALX3
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing ALX3
    DNA2.0 Custom Variant and Variant Library Synthesis for ALX3

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 606014   
    OMIM disorders: 136760  
    UniProtKB/Swiss-Prot: ALX3_HUMAN, O95076
  • Frontonasal dysplasia 1 (FND1) [MIM:136760]: The term frontonasal dysplasia describes an array of
    abnormalities affecting the eyes, forehead and nose and linked to midfacial dysraphia. The clinical picture is
    highly variable. Major findings include true ocular hypertelorism; broadening of the nasal root; median facial
    cleft affecting the nose and/or upper lip and palate; unilateral or bilateral clefting of the alae nasi; lack of
    formation of the nasal tip; anterior cranium bifidum occultum; a V-shaped or widow's peak frontal hairline.
    Note=The disease is caused by mutations affecting the gene represented in this entry

  • 8 diseases for ALX3:    About MalaCards
    basal encephalocele    frontonasal dysplasia    frontonasal dysplasia 1    encephalocele
    encephaloceles    neuroblastoma    polydactyly    pancreatitis

    1 disease from the University of Copenhagen DISEASES database for ALX3:
    Polydactyly

    ALX3 for disorders           About GeneDecksing

    Genetic Association Database (GAD): ALX3
    Human Genome Epidemiology (HuGE) Navigator: ALX3 (1 document)

    Export disorders for ALX3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ALX3 gene, integrated from 9 sources (see all 12):
    (articles sorted by number of sources associating them with ALX3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Combined restriction landmark genomic scanning and virtual genome scans identify a novel human homeobox gene, ALX3, that is hypermethylated in neuroblastoma. (PubMed id 11807986)1, 2, 3, 9 Wimmer K.... Hanash S.M. (2002)
    2. Maternal genes and facial clefts in offspring: a comp rehensive search for genetic associations in two population-based cleft studies from Scandinavia. (PubMed id 20634891)1, 4 Jugessur A....Murray J.C. (2010)
    3. Frontorhiny, a distinctive presentation of frontonasa l dysplasia caused by recessive mutations in the ALX3 homeobox gene. (PubMed id 19409524)1, 2 Twigg S.R....Wilkie A.O. (2009)
    4. The homeoprotein Alx3 contains discrete functional domains and exhibits cell-specific and selective monomeric binding and transactivation. (PubMed id 15226305)1, 3 Perez-Villamil B....Vallejo M. (2004)
    5. Exclusion of mutations in TGIF, ALX3, and ALX4 genes i n patients with the syndrome of frontonasal dysgenesis, callosal agenesis, basal encephalocele, and eye anomalies. (PubMed id 22496059)1 Ribeiro-Bicudo L.A....Richieri-Costa A. (2012)
    6. Genome-wide association for abdominal subcutaneous and visceral adipose reveals a novel locus for visceral fat in women. (PubMed id 22589738)1 Fox C.S....Borecki I.B. (2012)
    7. Clinical and genetic characterization of frontorhiny: report of 3 novel cases and discussion of the surgical management. (PubMed id 22106187)1 Pham N.S....Tollefson T.T. (2011)
    8. The homeoprotein Alx3 expressed in pancreatic beta-cells regulates insulin gene transcription by interacting with the basic helix-loop-helix protein E47. (PubMed id 16825292)1 Mirasierra M. and Vallejo M. (2006)
    9. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)2 Gregory S.G.... Bentley D.R. (2006)
    10. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)

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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 257 HGNC: 449 AceView: ALX3 Ensembl:ENSG00000156150 euGenes: HUgn257
    ECgene: ALX3 H-InvDB: ALX3

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ALX3 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for ALX3 gene:
    Search GeneIP for patents involving ALX3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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