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ALX3 Gene

protein-coding   GIFtS: 47
GCID: GC01M110602

ALX Homeobox 3

(Previous names: aristaless-like homeobox 3, frontonasal dysplasia)
(Previous symbol: FND)
  See ALX3-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
ALX Homeobox 31 2     Proline-Rich Transcription Factor ALX32 3
FND1 2     FND12 5
Aristaless-Like Homeobox 31 2     Homeobox Protein Aristaless-Like 32
Frontonasal Dysplasia1 2     

External Ids:    HGNC: 4491   Entrez Gene: 2572   Ensembl: ENSG000001561507   OMIM: 6060145   UniProtKB: O950763   

Export aliases for ALX3 gene to outside databases

Previous GC identifers: GC01M111018 GC01M109469 GC01M109704 GC01M109901 GC01M110314 GC01M110404 GC01M108472


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for ALX3 Gene:
This gene encodes a nuclear protein with a homeobox DNA-binding domain that functions as a transcriptional
regulator involved in cell-type differentiation and development. Preferential methylation of this gene's promoter
is associated with advanced-stage neuroblastoma tumors. (provided by RefSeq, Jul 2008)

GeneCards Summary for ALX3 Gene:
ALX3 (ALX homeobox 3) is a protein-coding gene. Diseases associated with ALX3 include encephaloceles, and frontonasal dysplasia 1. GO annotations related to this gene include sequence-specific DNA binding and sequence-specific DNA binding transcription factor activity. An important paralog of this gene is ALX1.

UniProtKB/Swiss-Prot: ALX3_HUMAN, O95076
Function: Transcriptional regulator with a possible role in patterning of mesoderm during development (By
similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Regulatory elements:
   Regulatory transcription factor binding sites in the ALX3 gene promoter:
         p300   IRF-1   Nkx2-5   E47   CBF-A   CBF-B   CP1A   NF-Y   Pax-4a   CBF(2)   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidALX3 promoter sequence
   Search Chromatin IP Primers for ALX3

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ALX3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p13.3   Ensembl cytogenetic band:  1p13.3   HGNC cytogenetic band: 1p13.3

ALX3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ALX3 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M110602:  view genomic region     (about GC identifiers)

Start:
110,602,616 bp from pter      End:
110,613,322 bp from pter
Size:
10,707 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: ALX3_HUMAN, O95076 (See protein sequence)
Recommended Name: Homeobox protein aristaless-like 3  
Size: 343 amino acids; 36935 Da
Secondary accessions: O95075 Q5T8M4

Explore the universe of human proteins at neXtProt for ALX3: NX_O95076

Explore proteomics data for ALX3 at MOPED


See ALX3 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins: NP_006483.2  
ENSEMBL proteins: 
 ENSP00000358807  

ALX3 Human Recombinant Protein Products:

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Cloud-Clone Corp. Proteins for ALX3

 
Search eBioscience for Proteins for ALX3 

 
antibodies-online proteins for ALX3 (4 products) 

 
antibodies-online peptides for ALX3

ALX3 Antibody Products:

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antibodies-online antibodies for ALX3 (21 products) 

ALX3 Assay Products:

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Cloud-Clone Corp. ELISAs for ALX3
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antibodies-online kits for ALX3 (4 products) 


(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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HGNC Gene Families:
PRD: Homeoboxes / PRD class

3 InterPro protein domains:
 IPR017970 Homeobox_CS
 IPR001356 Homeobox_dom
 IPR009057 Homeodomain-like

Graphical View of Domain Structure for InterPro Entry O95076

ProtoNet protein and cluster: O95076

UniProtKB/Swiss-Prot: ALX3_HUMAN, O95076
Similarity: Belongs to the paired homeobox family
Similarity: Contains 1 homeobox DNA-binding domain


Find genes that share domains with ALX3           About GenesLikeMe


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Molecular Function:

     UniProtKB/Swiss-Prot Summary: ALX3_HUMAN, O95076
Function: Transcriptional regulator with a possible role in patterning of mesoderm during development (By
similarity)

     Gene Ontology (GO): 3 molecular function terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0003677DNA binding ----
GO:0003700sequence-specific DNA binding transcription factor activity IEA--
GO:0043565sequence-specific DNA binding IEA--
     
Find genes that share ontologies with ALX3           About GenesLikeMe


Phenotypes:
     1 GenomeRNAi human phenotype for ALX3:
 Decreased cilium length after  

     15 MGI mutant phenotypes (inferred from 1 allele(MGI details for Alx3):
 behavior/neurological  cellular  craniofacial  digestive/alimentary  embryogenesis 
 endocrine/exocrine gland  growth/size/body  homeostasis/metabolism  limbs/digits/tail  mortality/aging 
 nervous system  reproductive system  respiratory system  skeleton  vision/eye 

Find genes that share phenotypes with ALX3           About GenesLikeMe

Animal Models:
   genOway: Develop your customized and physiologically relevant rodent model for ALX3

miRNA
Products:
    
Block miRNA regulation of human, mouse, rat ALX3 using miScript Target Protectors
Selected qRT-PCR Assays for microRNAs that regulate ALX3 (see all 9):
hsa-miR-10b hsa-miR-4306 hsa-miR-650 hsa-miR-504 hsa-miR-10a hsa-miR-3667-5p hsa-miR-670 hsa-miR-185
SwitchGear 3'UTR luciferase reporter plasmidALX3 3' UTR sequence
Inhib. RNA
Products:
    
OriGene RNAi products in human, mouse, rat for ALX3
Predesigned siRNA for gene silencing in human, mouse, rat ALX3

Gene Editing
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DNA2.0 Custom Protein Engineering Service for ALX3

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GenScript: all cDNA clones in your preferred vector: ALX3 (NM_006492)
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DNA2.0 Custom Codon Optimized Gene Synthesis Service for ALX3
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ALX3

Cell Line
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In Situ Assay
Products:
   

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ALX3


(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from UniProtKB/Swiss-Prot
ALX3_HUMAN, O95076: Nucleus (By similarity)
Subcellular locations from COMPARTMENTS: 

CompartmentConfidence
nucleus3

Gene Ontology (GO): 1 cellular component term:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005634nucleus IEA--

Find genes that share ontologies with ALX3           About GenesLikeMe


(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for ALX3
Interactions:

    Search GeneGlobe Interaction Network for ALX3

STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

2 Interacting proteins for ALX3 (O950763 ENSP000003588074) via UniProtKB, MINT, STRING, and/or I2D
InteractantInteraction Details
GeneCardExternal ID(s)
JDP2Q8WYK23, ENSP000002675694I2D: score=1 STRING: ENSP00000267569
CHEK2ENSP000003720234STRING: ENSP00000372023
About this table

Gene Ontology (GO): Selected biological process terms (see all 7):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0006351transcription, DNA-templated IEA--
GO:0006355regulation of transcription, DNA-templated ----
GO:0007389pattern specification process IEA--
GO:0035115embryonic forelimb morphogenesis IEA--
GO:0035116embryonic hindlimb morphogenesis IEA--

Find genes that share ontologies with ALX3           About GenesLikeMe



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore
   Browse drugs & compounds from Enzo Life Sciences
  Browse compounds at ApexBio 

Browse Tocris compounds for ALX3



(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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REFSEQ mRNAs for ALX3 gene: 
NM_006492.2  

1 Ensembl transcript including schematic representation, and UCSC links where relevant:
ENST00000369792(uc001dzb.3)
miRNA
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Block miRNA regulation of human, mouse, rat ALX3 using miScript Target Protectors
Selected qRT-PCR Assays for microRNAs that regulate ALX3 (see all 9):
hsa-miR-10b hsa-miR-4306 hsa-miR-650 hsa-miR-504 hsa-miR-10a hsa-miR-3667-5p hsa-miR-670 hsa-miR-185
SwitchGear 3'UTR luciferase reporter plasmidALX3 3' UTR sequence
Inhib. RNA
Products:
     
OriGene RNAi products in human, mouse, rat for ALX3
Predesigned siRNA for gene silencing in human, mouse, rat ALX3
Clone
Products:
     
OriGene clones in human, mouse for ALX3 (see all 5)
OriGene ORF clones in mouse, rat for ALX3
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
GenScript: all cDNA clones in your preferred vector: ALX3 (NM_006492)
DNA2.0 Custom Codon Optimized Gene Synthesis Service for ALX3
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ALX3
Primer
Products:
    
OriGene qSTAR qPCR primer pairs in human, mouse for ALX3
Pre-validated RT2 qPCR Primer Assay in human, mouse, rat ALX3
  QuantiTect SYBR Green Assays in human, mouse, rat ALX3
  QuantiFast Probe-based Assays in human, mouse, rat ALX3

3 AceView cDNA sequences:

NM_006492 AF008203 CD622788 

GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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ALX3 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: CAGTCATCTT
ALX3 Expression
About this image


ALX3 expression in embryonic tissues and stem cells    About this table
Data from LifeMap, the Embryonic Development and Stem Cells Database
 selected tissues (see all 7) fully expand
 
 Neural Tube (Nervous System)    fully expand to see all 2 entries
         Spinal Ventral Columns
 
 Dermis (Integumentary System)    fully expand to see all 2 entries
         Zigzag Dermal Papilla Cells Dermal Papilla
 
 Gut Tube (Gastrointestinal Tract)
         Foregut
 
 Limb (Muscoskeletal System)
         Limb Muscle Progenitor Cells Forelimb Myotome
 
 Liver (Hepatobiliary System)
         Mesothelial Cells Hepatic Mesenchyme
ALX3 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

ALX3 Protein Expression
    Custom PCR Arrays for ALX3
Primer
Products:
OriGene qSTAR qPCR primer pairs in human, mouse for ALX3
Pre-validated RT2 qPCR Primer Assay in human, mouse, rat ALX3
QuantiTect SYBR Green Assays in human, mouse, rat ALX3
QuantiFast Probe-based Assays in human, mouse, rat ALX3
In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ALX3

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of chordates.

Orthologs for ALX3 gene from Selected species (see all 9)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Alx31 , 5 aristaless-like homeobox 31, 5 88.82(n)1
91.84(a)1
  3 (46.83 cM)5
116941  NM_007441.31  NP_031467.11 
 1075950315 
chicken
(Gallus gallus)
Aves ALX31 ALX homeobox 3 74.18(n)
71.43(a)
  100859561  XM_003642735.2  XP_003642783.2 
zebrafish
(Danio rerio)
Actinopterygii LOC5669551 homeobox protein aristaless-like 3-like 62.29(n)
59.46(a)
  566955  XM_005167111.1  XP_005167168.1 


ENSEMBL Gene Tree for ALX3 (if available)
TreeFam Gene Tree for ALX3 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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Paralogs for ALX3 gene
ALX12  PHOX2B2  ARX2  RAX2  DRGX2  SHOX22  PRRX12  PHOX2A2  
ALX42  ISX2  RAX22  SHOX2  OTP2  PRRX22  
2 SIMAP similar genes for ALX3 using alignment to 1 protein entry:     ALX3_HUMAN:
ALX1    ALX4

Find genes that share paralogs with ALX3           About GenesLikeMe



(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for ALX3 (see all 310)    About this table                                 

Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 1 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs1219081701,2,,4
CFrontonasal dysplasia 1 (FND1)4 pathogenic1110680011(-) AGGCCC/TGGGTA 2 R W mis10--------
VAR_0632294
Frontonasal dysplasia 1 (FND1)4--see VAR_0632292 N S mis40--------
VAR_0632264
Frontonasal dysplasia 1 (FND1)4--see VAR_0632262 L V mis40--------
VAR_0632274
Frontonasal dysplasia 1 (FND1)4--see VAR_0632272 R W mis40--------
rs572799631,2
C--110605267(+) GTGTG-/TGAGTA 1 -- int10--------
rs346548831,2
C--110605268(+) GTGTG-/G/TC  
        
AGTAA
1 -- int10--------
rs1444726071,2
--110675299(+) AACACC/TACCAC 1 -- ds50010--------
rs1926567411,2
--110675479(+) GGCTGA/GTCCCG 1 -- ds50010--------
rs412813601,2
C,F--110675667(+) CAGACA/GCCAGT 1 -- ds50012Minor allele frequency- G:0.15WA 120
rs1155414621,2
C,F--110675674(+) CAGTGC/TGCCCC 1 -- ds50011Minor allele frequency- T:0.01WA 118

HapMap Linkage Disequilibrium report for ALX3 (110602616 - 110613322 bp)

Structural Variations
      Database of Genomic Variants (DGV) variations for ALX3: --
Human Gene Mutation Database (HGMD): ALX3
Site Specific Mutation Identification with PCR Assays
SeqTarget long-range PCR primers for resequencing ALX3
DNA2.0 Custom Variant and Variant Library Synthesis for ALX3

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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OMIM gene information: 606014   
OMIM disorders: 136760  
UniProtKB/Swiss-Prot: ALX3_HUMAN, O95076
  • Frontonasal dysplasia 1 (FND1) [MIM:136760]: The term frontonasal dysplasia describes an array of
    abnormalities affecting the eyes, forehead and nose and linked to midfacial dysraphia. The clinical picture is
    highly variable. Major findings include true ocular hypertelorism; broadening of the nasal root; median facial
    cleft affecting the nose and/or upper lip and palate; unilateral or bilateral clefting of the alae nasi; lack of
    formation of the nasal tip; anterior cranium bifidum occultum; a V-shaped or widow's peak frontal hairline.
    Note=The disease is caused by mutations affecting the gene represented in this entry

  • 6 diseases for ALX3:    
    About MalaCards
    encephaloceles    frontonasal dysplasia 1    basal encephalocele    frontonasal dysplasia
    encephalocele    neuroblastoma

    1 disease from the University of Copenhagen DISEASES database for ALX3:
    Polydactyly

    Find genes that share disorders with ALX3           About GenesLikeMe

    Genetic Association Database (GAD): ALX3
    Human Genome Epidemiology (HuGE) Navigator: ALX3 (1 document)

    Export disorders for ALX3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ALX3 gene, integrated from 10 sources (see all 13):
    (articles sorted by number of sources associating them with ALX3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Combined restriction landmark genomic scanning and virtual genome scans identify a novel human homeobox gene, ALX3, that is hypermethylated in neuroblastoma. (PubMed id 11807986)1, 2, 3, 9 Wimmer K.... Hanash S.M. (Genes Chromosomes Cancer 2002)
    2. Frontorhiny, a distinctive presentation of frontonasal dysplasia caused by recessive mutations in the ALX3 homeobox gene. (PubMed id 19409524)1, 2, 3 Twigg S.R.F.... Wilkie A.O.M. (Am. J. Hum. Genet. 2009)
    3. Maternal genes and facial clefts in offspring: a comprehensive search for genetic associations in two population-based cleft studies from Scandinavia. (PubMed id 20634891)1, 4 Jugessur A....Murray J.C. (PLoS ONE 2010)
    4. The homeoprotein Alx3 contains discrete functional domains and exhibits cell-specific and selective monomeric binding and transactivation. (PubMed id 15226305)1, 3 PAcrez-Villamil B....Vallejo M. (J. Biol. Chem. 2004)
    5. Exclusion of mutations in TGIF, ALX3, and ALX4 genes in patients with the syndrome of frontonasal dysgenesis, callosal agenesis, basal encephalocele, and eye anomalies. (PubMed id 22496059)1 Ribeiro-Bicudo L.A....Richieri-Costa A. (Am. J. Med. Genet. A 2012)
    6. Genome-wide association for abdominal subcutaneous and visceral adipose reveals a novel locus for visceral fat in women. (PubMed id 22589738)1 Fox C.S....Borecki I.B. (PLoS Genet. 2012)
    7. Clinical and genetic characterization of frontorhiny: report of 3 novel cases and discussion of the surgical management. (PubMed id 22106187)1 Pham N.S....Tollefson T.T. (Arch Facial Plast Surg 2011)
    8. A whole genome screen for HIV restriction factors. (PubMed id 22082156)1 Liu L....McKnight A. (Retrovirology 2011)
    9. The homeoprotein Alx3 expressed in pancreatic beta-cells regulates insulin gene transcription by interacting with the basic helix-loop-helix protein E47. (PubMed id 16825292)1 Mirasierra M. and Vallejo M. (Mol. Endocrinol. 2006)
    10. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)2 Gregory S.G.... Bentley D.R. (Nature 2006)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 257 HGNC: 449 AceView: ALX3 Ensembl:ENSG00000156150 euGenes: HUgn257
    ECgene: ALX3 H-InvDB: ALX3

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for ALX3 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for ALX3 gene:
    Search GeneIP for patents involving ALX3

    GeneCards and IP:
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