Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ALX3 Gene

protein-coding   GIFtS: 48
GCID: GC01M110602

ALX homeobox 3

(Previous name: aristaless-like homeobox 3 )
 Explore 4 diseases affiliated with
ALX3 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for ALX3    

Aliases
for ALX3 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
ALX Homeobox 31 2
Aristaless-Like Homeobox 31 2
Proline-Rich Transcription Factor ALX32 3
FND12
Homeobox Protein Aristaless-Like 32

External Ids:    HGNC: 4491   Entrez Gene: 2572   Ensembl: ENSG000001561507   OMIM: 6060145   UniProtKB: O950763   

Export aliases for ALX3 gene to outside databases

Previous GC identifers: GC01M111018 GC01M109469 GC01M109704 GC01M109901 GC01M110314 GC01M110404 GC01M108472


Summaries
for ALX3 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for ALX3:
This gene encodes a nuclear protein with a homeobox DNA-binding domain that functions as a transcriptional regulator
involved in cell-type differentiation and development. Preferential methylation of this gene's promoter is associated
with advanced-stage neuroblastoma tumors. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: ALX3_HUMAN, O95076
Function: Transcriptional regulator with a possible role in patterning of mesoderm during development (By similarity)




Genomic Views
for ALX3 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NC_018912.1  NT_032977.9  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ALX3 gene promoter:
         p300   IRF-1   Nkx2-5   E47   CBF-A   CBF-B   CP1A   NF-Y   Pax-4a   CBF(2)   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: ALX3 promoter sequence
   Search SABiosciences Chromatin IP Primers for ALX3

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ALX3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p13.3   Ensembl cytogenetic band:  1p13.3   HGNC cytogenetic band: 1p13.3

ALX3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ALX3 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M110602:  view genomic region     (about GC identifiers)

Start:
 110,602,616 bp from pter      End:
 110,613,322 bp from pter
Size:
 10,707 bases      Orientation:
 minus strand

Proteins
for ALX3 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: ALX3_HUMAN, O95076 (See protein sequence)
Recommended Name: Homeobox protein aristaless-like 3  
Size: 343 amino acids; 36935 Da
Subcellular location: Nucleus (By similarity)
Secondary accessions: O95075 Q5T8M4

Explore the universe of human proteins at neXtProt for ALX3: NX_O95076

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_O95076

    • ALX3 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_006483.2  
    ENSEMBL proteins: 
     ENSP00000358807  

    Human Recombinant Protein Products: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    Browse OriGene Protein Over-expression Lysates
    OriGene Custom Protein Services for ALX3 
    GenScript Custom Purified and Recombinant Proteins Services for ALX3
    Novus Biologicals ALX3 Protein
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for ALX3

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--


    ALX3 for ontologies           About GeneDecksing



    ALX3 Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for ALX3 
    GenScript Custom Superior Antibodies Services for ALX3
    Novus Biologicals ALX3 Antibodies
    Search for Antibodies for ALX3 at Abcam  
    Uscn Antibodies for ALX3
    Search ThermoFisher Antibodies for ALX3

    Assay Products for ALX3: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Immunoassay Development
    Browse OriGene Fluorogenic Cell Assay Kits
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for ALX3
    Browse Enzo Life Sciences for kits & assays
    Uscn ELISAs and CLIAs for ALX3

    Protein Domains /
    Families
    for ALX3 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    ALX3 for domains           About GeneDecksing

    3 InterPro domains/families:
     IPR017970 Homeobox_CS
     IPR001356 Homeodomain
     IPR009057 Homeodomain-like

    Graphical View of Domain Structure for InterPro Entry O95076

    ProtoNet protein and cluster: O95076

    UniProtKB/Swiss-Prot: ALX3_HUMAN, O95076
    Similarity: Belongs to the paired homeobox family
    Similarity: Contains 1 homeobox DNA-binding domain


    Function
    for ALX3 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: ALX3_HUMAN, O95076
    Function: Transcriptional regulator with a possible role in patterning of mesoderm during development (By similarity)

    miRNA
    Products:            		Browse 3'-UTR reporter clones for miRNA target validation
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ALX3
    8/9 QIAGEN miScript miRNA Assays for microRNAs that regulate ALX3 (see all 9):
    hsa-miR-10b hsa-miR-4306 hsa-miR-650 hsa-miR-504 hsa-miR-10a hsa-miR-3667-5p hsa-miR-670 hsa-miR-185
    SwitchGear 3'UTR luciferase reporter plasmid: ALX3 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ALX3 (see all 7)
    OriGene shRNA RFP: ALX3
    OriGene siRNA: ALX3
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ALX3

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for ALX3

    Clone
    Products:             		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ALX3 (see all 3)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ALX3
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: ALX3 (NM_006492)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ALX3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ALX3 

    Cell Line
    Products:             		GenScript Custom overexpressing Cell Line Services for ALX3
    Search LifeMap BioReagents cell lines for ALX3

    In Situ Assay
    Products:       
         		Search Advanced Cell Diagnostics for RNAscope RNA in situ hybridization assays for ALX3

    Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003700sequence-specific DNA binding transcription factor activity IEA--
    GO:0043565sequence-specific DNA binding IEA--


    ALX3 for ontologies           About GeneDecksing


    1 GenomeRNAi human phenotype for ALX3:
     Decreased cilium length after  

    Animal Models:
         10 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Alx3):
     behavior/neurological  craniofacial  digestive/alimentary  growth/size  limbs/digits/tail 
     mortality/aging  normal  respiratory system  skeleton  vision/eye 

    ALX3 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for ALX3 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ALX3

    1 Interacting protein for ALX3 (O950763) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    JDP2Q8WYK23I2D: score=1 
    About this table

    Gene Ontology (GO): 5/7 biological process terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-dependent IEA--
    GO:0007275multicellular organismal development ----
    GO:0007389pattern specification process IEA--
    GO:0035115embryonic forelimb morphogenesis IEA--
    GO:0035116embryonic hindlimb morphogenesis IEA--


    ALX3 for ontologies           About GeneDecksing



    Drugs & Compounds
    for ALX3 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ALX3
    Search CenterWatch for drugs/clinical trials and news about ALX3 

    Transcripts
    for ALX3 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for ALX3 gene: 
    NM_006492.2  

    Unigene Cluster for ALX3:

    ALX homeobox 3
    Hs.669953  [show with all ESTs]
    Unigene Representative Sequence: AF008203
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000369792(uc001dzb.3)

    miRNA
    Products:             		Browse 3'-UTR reporter clones for miRNA target validation
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ALX3
    8/9 QIAGEN miScript miRNA Assays for microRNAs that regulate ALX3 (see all 9):
    hsa-miR-10b hsa-miR-4306 hsa-miR-650 hsa-miR-504 hsa-miR-10a hsa-miR-3667-5p hsa-miR-670 hsa-miR-185
    SwitchGear 3'UTR luciferase reporter plasmid: ALX3 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ALX3 (see all 7)
    OriGene shRNA RFP: ALX3
    OriGene siRNA: ALX3
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ALX3
    Clone
    Products:             		 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ALX3 (see all 3)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ALX3
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: ALX3 (NM_006492)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ALX3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ALX3 
    Primer
    Products:            		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ALX3
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat ALX3
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ALX3
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ALX3

    Additional cDNA sequence: 

    AF008203.1 BC112007.1 BC113428.1 

    4 DOTS entries:

    DT.310753  DT.121360898  DT.91657690  DT.121360894 

    3 AceView cDNA sequences:

    AF008203 NM_006492 CD622788 

    GeneLoc Exon Structure


    Expression
    for ALX3 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ALX3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: CAGTCATCTT

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    ALX3 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    6 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    LimbForelimb MyotomeLimb Muscle Progenitor CellsSkeletal Muscle
    Spinal CordSpinal Dorsal ColumnsDorsal Spinal Cord Progenitor CellsSpinal Cord
    Spinal CordSpinal Ventral ColumnsVentral Spinal Cord Progenitor CellsMotor Neurons
    Head MesenchymeFrontonasal ProcessHead Mesenchyme
    Spinal CordSpinal Dorsal ColumnsSpinal Cord
    Spinal CordSpinal Ventral ColumnsSpinal Cord
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See ALX3 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ALX3

    SOURCE GeneReport for Unigene cluster: Hs.669953
        SABiosciences Custom PCR Arrays for ALX3
    Primer
    Products:    		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ALX3
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat ALX3
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ALX3
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ALX3
    In Situ
    Assay Products:     
         		Search Advanced Cell Diagnostics for RNAscope RNA in situ hybridization assays for ALX3

    Orthologs
    for ALX3 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of chordates.

    Orthologs for ALX3 gene from 2/12 species (see all 12)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves LOC1008595611 homeobox protein aristaless-like 3-like 67.82(n)
    61.9(a)    		   100859561  XM_003642735.1  XP_003642783.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii LOC5669551 homeobox protein aristaless-like 3-like 62.14(n)
    58.91(a)    		   566955  XM_690238.1  XP_695330.1 


    ENSEMBL Gene Tree for ALX3 (if available)
    TreeFam Gene Tree for ALX3 (if available) 

    Paralogs
    for ALX3 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ALX3 gene
    ALX12  PITX12  PHOX2B2  RAX2  ARX2  VSX12  PRRX12  DRGX2  
    PITX22  PHOX2A2  VSX22  ISX2  ALX42  RAX22  PITX32  PRRX22  
    2 SIMAP similar genes for ALX3 using alignment to 1 protein entry:     ALX3_HUMAN:
    ALX1    ALX4

    ALX3 for paralogs           About GeneDecksing



    Genomic Variants
    for ALX3 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/254 NCBI SNPs in ALX3 are shown (see all 254)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 1 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1219081701,2
    		C,pathogenic110607217(-) AGGCCC/TGGGTA 2 R W mis10--------
    rs1444726071,2
    		--110602504(+) AACACC/TACCAC 1 -- ds50010--------
    rs1926567411,2
    		--110602684(+) GGCTGA/GTCCCG 1 -- ds50010--------
    rs412813601,2
    		C,--110602872(+) CAGACA/GCCAGT 1 -- ds50012Minor allele frequency- G:0.15WA 120
    rs1155414621,2
    		--110602879(+) CAGTGC/TGCCCC 1 -- ds50011Minor allele frequency- T:0.01WA 118
    rs741173321,2
    		C,--110602975(+) AGTCCA/GCGCGG 1 -- ds50012Minor allele frequency- G:0.10WA 120
    rs1836063371,2
    		--110602979(+) CACGCG/TGCGTT 1 -- ds50010--------
    rs10274621,2
    		C,F,H,--110602982(+) GCGGCG/ATTCTC 1 -- ds5001 ese318Minor allele frequency- A:0.09MN NS EA NA WA CSA 1822
    rs10274631,2
    		C,F,H,--110603043(+) CTGGAG/CAGATG 1 -- ut31 ese320Minor allele frequency- C:0.11MN NS EA NA WA CSA 2210
    rs1882594411,2
    		--110603100(+) TGCCTC/GCAGCC 1 -- ut310--------

    HapMap Linkage Disequilibrium report for ALX3 (110602616 - 110613322 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for ALX3: --
    Human Gene Mutation Database (HGMD): ALX3

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ALX3
    DNA2.0 Custom Variant and Variant Library Synthesis for ALX3

    Disorders / Diseases
    for ALX3 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    ALX3 for disorders           About GeneDecksing

    OMIM gene information: 606014   
    OMIM disorders: 136760  
    UniProtKB/Swiss-Prot: ALX3_HUMAN, O95076
  • Defects in ALX3 are the cause of frontonasal dysplasia type 1 (FND1) [MIM:136760]; also called frontonasal
    • malformation (FNM) or frontorhiny. The term frontonasal dysplasia describes an array of abnormalities affecting the
    eyes, forehead and nose and linked to midfacial dysraphia. The clinical picture is highly variable. Major findings
    include true ocular hypertelorism; broadening of the nasal root; median facial cleft affecting the nose and/or upper
    lip and palate; unilateral or bilateral clefting of the alae nasi; lack of formation of the nasal tip; anterior
    cranium bifidum occultum; a V-shaped or widow's peak frontal hairline

    4 diseases for ALX3:    About MalaCards
    neuroblastoma    frontonasal dysplasia    polydactyly    pancreatitis

    1 disease from the University of Copenhagen DISEASES database for ALX3:
    Polydactyly
    Human Genome Epidemiology (HuGE) Navigator: ALX3 (1 document)

    Export disorders for ALX3 gene to outside databases

    Publications
    for ALX3 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ALX3 gene, integrated from 9 sources (see all 12):
    (articles sorted by number of sources associating them with ALX3)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Combined restriction landmark genomic scanning and virtual genome scans identify a novel human homeobox gene, ALX3, that is hypermethylated in neuroblastoma. (PubMed id 11807986)1, 2, 3, 9 Wimmer K.... Hanash S.M. (2002)
    2. Frontorhiny, a distinctive presentation of frontonasa l dysplasia caused by recessive mutations in the ALX3 homeobox gene. (PubMed id 19409524)1, 2 Twigg S.R....Wilkie A.O. (2009)
    3. The homeoprotein Alx3 contains discrete functional domains and exhibits cell-specific and selective monomeric binding and transactivation. (PubMed id 15226305)1, 3 Perez-Villamil B....Vallejo M. (2004)
    4. Exclusion of mutations in TGIF, ALX3, and ALX4 genes i n patients with the syndrome of frontonasal dysgenesis, callosal agenesis, basal encephalocele, and eye anomalies. (PubMed id 22496059)1 Ribeiro-Bicudo L.A....Richieri-Costa A. (2012)
    5. Genome-wide association for abdominal subcutaneous and visceral adipose reveals a novel locus for visceral fat in women. (PubMed id 22589738)1 Fox C.S....Borecki I.B. (2012)
    6. Clinical and genetic characterization of frontorhiny: report of 3 novel cases and discussion of the surgical management. (PubMed id 22106187)1 Pham N.S....Tollefson T.T. (2011)
    7. Maternal genes and facial clefts in offspring: a comp rehensive search for genetic associations in two population-based cleft studies from Scandinavia. (PubMed id 20634891)1 Jugessur A....Murray J.C. (2010)
    8. The homeoprotein Alx3 expressed in pancreatic beta-cells regulates insulin gene transcription by interacting with the basic helix-loop-helix protein E47. (PubMed id 16825292)1 Mirasierra M. and Vallejo M. (2006)
    9. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)2 Gregory S.G.... Bentley D.R. (2006)
    10. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)

    External Searches for ALX3 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing ALX3 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 257 HGNC: 449 AceView: ALX3 Ensembl:ENSG00000156150 euGenes: HUgn257
    ECgene: ALX3 H-InvDB: ALX3

    Other Databases showing ALX3 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing ALX3 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ALX3 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for ALX3 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for ALX3 gene:
    Search GeneIP for patents involving ALX3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    Products
    for ALX3 gene

    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
    In Situ Hybridization Assays from
    Advanced Cell Diagnostics
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Phosphatase Activity Assays/Reagents   Browse Recombinant/Natural Proteins  
     Browse OriGene Antibodies   OriGene shRNA RFP for ALX3  
     OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ALX3   OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ALX3  
     Browse OriGene Protein Over-expression Lysates   Browse OriGene Fluorogenic Cell Assay Kits  
     OriGene siRNA for ALX3   Browse 3'-UTR reporter clones for miRNA target validation  
     OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ALX3   OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ALX3  
     Browse OriGene GFP tagged cDNA clones in CMV expression vector   Browse OriGene MicroRNA Expression Plasmids  
     Browse OriGene basic RS shRNAs   Browse OriGene validated miRNA SYBR primer pairs  
     Browse OriGene full length recombinant human proteins expressed in human HEK293 cells   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for ALX3   OriGene Custom Protein Services for ALX3  
     OriGene Custom Immunoassay Development  

         		 
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat ALX3
     QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ALX3
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ALX3
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ALX3
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ALX3
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ALX3
     GenScript Custom Purified and Recombinant Proteins Services for ALX3 GenScript cDNA clones with any tag delivered in your preferred vector for ALX3
     GenScript Custom Assay Services for ALX3 GenScript Custom Superior Antibodies Services for ALX3
     GenScript Custom overexpressing Cell Line Services for ALX3 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in ALX3 promoter
     Search Chromatin IP Primers for ALX3
     RT2 qPCR Primer Assay in human, mouse, rat ALX3
     Search GNC Networks for ALX3
     SABiosciences Custom PCR Arrays for ALX3
     Search Tocris compounds for ALX3
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological cDNA Clones
     Antibodies/Proteins Production Services
     Rabbit Monoclonal Antibody Platform
     Bulk Purchasing
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     ALX3 antibodies
     ALX3 proteins
     Search for Antibodies for ALX3 at Abcam
     See all of Abcam's Antibodies, Kits and Proteins for ALX3
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     ALX3 Proteins, Antibodies, CLIAs, and ELISAs
     Search LifeMap BioReagents cell lines for ALX3
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Search Advanced Cell Diagnostics for RNAscope RNA in situ hybridization assays for ALX3
     SwitchGear 3'UTR luciferase reporter plasmids for ALX3
     SwitchGear Promoter luciferase reporter plasmids for ALX3
     Search ThermoFisher Antibodies for ALX3
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ALX3
           
    GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

    View Random Gene

    Category
    VWF
    (GIFTS: 73)
    von Willebrand factor
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 

    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Copyright © 1996-2013 , Weizmann Institute of Science. All Rights Reserved.
    Hot genes      Disease genes      ALX3 gene at Home site.
    hostname: 356980-web2.xennexinc.com index build: 100 solr: 1.4