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Aliases for ALS2CR11 Gene

Aliases for ALS2CR11 Gene

  • Amyotrophic Lateral Sclerosis 2 (Juvenile) Chromosome Region, Candidate 11 2 3

External Ids for ALS2CR11 Gene

Summaries for ALS2CR11 Gene

GeneCards Summary for ALS2CR11 Gene

ALS2CR11 (Amyotrophic Lateral Sclerosis 2 (Juvenile) Chromosome Region, Candidate 11) is a Protein Coding gene.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ALS2CR11 Gene

Genomics for ALS2CR11 Gene

Genomic Location for ALS2CR11 Gene

Start:
201,487,232 bp from pter
End:
201,619,182 bp from pter
Size:
131,951 bases
Orientation:
Minus strand

Genomic View for ALS2CR11 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ALS2CR11 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ALS2CR11 Gene

Regulatory Elements for ALS2CR11 Gene

Proteins for ALS2CR11 Gene

  • Protein details for ALS2CR11 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q53TS8-AL2SA_HUMAN
    Recommended name:
    Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 11 protein
    Protein Accession:
    Q53TS8
    Secondary Accessions:
    • C9IZH7
    • E9PGG4
    • Q8NCN6
    • Q96LN4

    Protein attributes for ALS2CR11 Gene

    Size:
    623 amino acids
    Molecular mass:
    71159 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ALS2CR11 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ALS2CR11 Gene

Proteomics data for ALS2CR11 Gene at MOPED

Post-translational modifications for ALS2CR11 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ALS2CR11 Gene

No data available for DME Specific Peptides for ALS2CR11 Gene

Domains for ALS2CR11 Gene

Protein Domains for ALS2CR11 Gene

InterPro:
ProtoNet:
genes like me logo Genes that share domains with ALS2CR11: view

No data available for Gene Families and UniProtKB/Swiss-Prot for ALS2CR11 Gene

Function for ALS2CR11 Gene

Gene Ontology (GO) - Molecular Function for ALS2CR11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with ALS2CR11: view

Phenotypes for ALS2CR11 Gene

genes like me logo Genes that share phenotypes with ALS2CR11: view

No data available for Molecular function , Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for ALS2CR11 Gene

Localization for ALS2CR11 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ALS2CR11 Gene COMPARTMENTS Subcellular localization image for ALS2CR11 gene
Compartment Confidence
nucleus 3
cytosol 2

No data available for Gene Ontology (GO) - Cellular Components for ALS2CR11 Gene

Pathways for ALS2CR11 Gene

SuperPathways for ALS2CR11 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ALS2CR11 Gene

None

No data available for Pathways by source for ALS2CR11 Gene

Transcripts for ALS2CR11 Gene

Unigene Clusters for ALS2CR11 Gene

Amyotrophic lateral sclerosis 2 (juvenile) chromosome region, candidate 11:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ALS2CR11 Gene

No ASD Table

Relevant External Links for ALS2CR11 Gene

GeneLoc Exon Structure for
ALS2CR11
ECgene alternative splicing isoforms for
ALS2CR11

Expression for ALS2CR11 Gene

mRNA expression in normal human tissues for ALS2CR11 Gene

mRNA differential expression in normal tissues according to GTEx for ALS2CR11 Gene

This gene is overexpressed in Testis (30.6).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for ALS2CR11 Gene

SOURCE GeneReport for Unigene cluster for ALS2CR11 Gene Hs.335788

genes like me logo Genes that share expressions with ALS2CR11: view

Orthologs for ALS2CR11 Gene

This gene was present in the common ancestor of mammals.

Orthologs for ALS2CR11 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ALS2CR11 36
  • 99.15 (n)
  • 97.92 (a)
ALS2CR11 37
  • 97 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ALS2CR11 36
  • 80.55 (n)
  • 65.57 (a)
ALS2CR11 37
  • 61 (a)
OneToOne
dog
(Canis familiaris)
Mammalia -- 37
  • 35 (a)
OneToMany
-- 37
  • 60 (a)
OneToMany
LOC609039 36
  • 81.58 (n)
  • 68.11 (a)
mouse
(Mus musculus)
Mammalia Als2cr11 16
Als2cr11 37
  • 45 (a)
OneToOne
LOC102636554 36
  • 73.48 (n)
  • 56.77 (a)
oppossum
(Monodelphis domestica)
Mammalia ALS2CR11 37
  • 46 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ALS2CR11 37
  • 56 (a)
OneToOne
Species with no ortholog for ALS2CR11:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ALS2CR11 Gene

ENSEMBL:
Gene Tree for ALS2CR11 (if available)
TreeFam:
Gene Tree for ALS2CR11 (if available)

Paralogs for ALS2CR11 Gene

No data available for Paralogs for ALS2CR11 Gene

Variants for ALS2CR11 Gene

Sequence variations from dbSNP and Humsavar for ALS2CR11 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs888013 -- 201,567,158(+) ctttc(C/T)taagt intron-variant
rs888014 -- 201,567,446(+) gaagt(C/G)ccaag intron-variant
rs888015 -- 201,567,593(+) gagct(A/G)atgtt intron-variant
rs959995 -- 201,491,258(+) TGGTA(C/G)TATCC intron-variant, reference, missense
rs963555 -- 201,549,832(+) TTACT(C/T)GCTAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ALS2CR11 Gene

Variant ID Type Subtype PubMed ID
nsv3111 CNV Insertion 18451855
esv24012 CNV Loss 19812545
esv2658936 CNV Deletion 23128226
nsv507063 CNV Insertion 20534489

Relevant External Links for ALS2CR11 Gene

HapMap Linkage Disequilibrium report
ALS2CR11

Disorders for ALS2CR11 Gene

No disorders were found for ALS2CR11 Gene.

No data available for UniProtKB/Swiss-Prot for ALS2CR11 Gene

Publications for ALS2CR11 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  3. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PMID: 15815621) Hillier L.W. … Wilson R.K. (Nature 2005) 3 4
  4. A gene encoding a putative GTPase regulator is mutated in familial amyotrophic lateral sclerosis 2. (PMID: 11586298) Hadano S. … Ikeda J.-E. (Nat. Genet. 2001) 2 3
  5. Gene expression profile of human bone marrow stromal cells: high-throughput expressed sequence tag sequencing analysis. (PMID: 11827452) Jia L. … Francomano C.A. (Genomics 2002) 3

Products for ALS2CR11 Gene

Sources for ALS2CR11 Gene

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