Home
GeneCards Guide
Suite
- MalaCards
- GeneALaCart
- GeneDecks
- GeneIP
- GeneLoc
Terms and Conditions
- Terms of Use
- 3rd Party Notice
About Us
User Feedback
Mirror sites

Set Analyses:

Generates a file of GeneCards annotations for your list of genes

Advanced Search

Search By

Section (entire)

for

All GeneCards Within gene subset (to enable gene prioritization):
or upload a file of gene symbols

Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

ALS2CL Gene

protein-coding GIFtS: 51
GCID: GC03M046685

ALS2 C-terminal like

Explore 5 diseases affiliated with
ALS2CL via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
ALS2 C-Terminal Like¹ ²
RN49018¹ ²
DKFZp686I0110¹
FLJ36525¹
ALS2 C-Terminal-Like Protein²

External Ids:	HGNC: 20605¹	Entrez Gene: 259173²	Ensembl: ENSG00000178038⁷	OMIM: 612402⁵	UniProtKB: Q60I27³

ORGUL members:
	NONCODE:n409415

Export aliases for ALS2CL gene to outside databases

Previous GC identifer: GC00U900924

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: AL2CL_HUMAN, Q60I27

Function: Acts as a guanine nucleotide exchange factor (GEF) for Rab5 GTPase. Regulates the ALS2-mediated endosome

dynamics

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000003.11 NC_018914.1 NT_022517.18

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the ALS2CL gene promoter:
Max1 Elk-1 NF-1 COMP1 c-Myc c-Ets-1
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: ALS2CL promoter sequence

Search SABiosciences Chromatin IP Primers for ALS2CL

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ALS2CL

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3p21.31 Ensembl cytogenetic band: 3p21.31 HGNC cytogenetic band: 3p21.31

ALS2CL Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ALS2CL gene location

GeneLoc information about chromosome 3 GeneLoc Exon Structure

GeneLoc location for GC03M046685: view genomic region (about GC identifiers)

Start:	46,710,485 bp from pter	End:	46,735,194 bp from pter
Size:	24,710 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: AL2CL_HUMAN, Q60I27 (See protein sequence)

Recommended Name: ALS2 C-terminal-like protein

Size: 953 amino acids; 107748 Da

Subunit: Homodimer. Forms a heteromeric complex with ALS2 (By similarity). Interacts with ALS2 and RAB5A

Subcellular location: Cytoplasm. Note=Distributed onto the vesicular compartments in the cytoplasm with strong

punctated staining. Colocalizes with RAB5A onto the vesicular/membranous compartments in the cytoplasm, particularly

to the leading edges of the cells

Sequence caution: Sequence=BAD18450.1; Type=Frameshift; Positions=878;

Secondary accessions: Q32MA1 Q6AI56 Q6ZNC5 Q6ZNC7 Q6ZTL4 Q86YD2 Q8N9U1 Q8NAL7

Alternative splicing: 6 isoforms: Q60I27-1 Q60I27-2 Q60I27-3 Q60I27-4 Q60I27-5 Q60I27-6 (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for ALS2CL: NX_Q60I27

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q60I27

ALS2CL Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (3 alternative transcripts):

NP_001177636.1 NP_667340.2 NP_877576.1

ENSEMBL proteins:

ENSP00000313670 ENSP00000405335 ENSP00000413223 ENSP00000373248 ENSP00000416575

ENSP00000395663 ENSP00000395749

Human Recombinant Protein Products:

	Browse Purified and Recombinant Proteins at EMD Millipore
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	OriGene Purified Protein: ALS2CL OriGene Protein Over-expression Lysate: ALS2CL OriGene Custom Protein Services for ALS2CL
	GenScript Custom Purified and Recombinant Proteins Services for ALS2CL
	Novus Biologicals ALS2CL Protein Novus Biologicals ALS2CL Lysates
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for ALS2CL

Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005622	intracellular	--	--
GO:0016023	cytoplasmic membrane-bounded vesicle	IEA	--

ALS2CL for ontologies About GeneDecksing

ALS2CL Antibody Products:

	Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Browse R&D Systems for Antibodies
	Browse OriGene Antibodies OriGene Custom Antibody Services for ALS2CL
	GenScript Custom Superior Antibodies Services for ALS2CL
	Novus Biologicals ALS2CL Antibody
	Search for Antibodies for ALS2CL at Abcam
	Uscn Antibodies for ALS2CL
	Search ThermoFisher Antibodies for ALS2CL

Assay Products for ALS2CL:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for ALS2CL
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for ALS2CL

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

ALS2CL for domains About GeneDecksing

3 InterPro domains/families:

IPR000219 DH-domain

IPR003123 VPS9

IPR003409 MORN

Graphical View of Domain Structure for InterPro Entry Q60I27

ProtoNet protein and cluster: Q60I27

UniProtKB/Swiss-Prot: AL2CL_HUMAN, Q60I27

Similarity: Contains 8 MORN repeats

Similarity: Contains 1 VPS9 domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: AL2CL_HUMAN, Q60I27

Function: Acts as a guanine nucleotide exchange factor (GEF) for Rab5 GTPase. Regulates the ALS2-mediated endosome

dynamics

miRNA Products:		OriGene 3'-UTR Clone (see all 2): ALS2CL Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ALS2CL
		1 QIAGEN miScript miRNA Assays for microRNA that regulate ALS2CL:
		hsa-miR-491-5p
		SwitchGear 3'UTR luciferase reporter plasmid: ALS2CL 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ALS2CL (see all 4) OriGene shRNA RFP: ALS2CL OriGene siRNA: ALS2CL
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ALS2CL

Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for ALS2CL

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ALS2CL (see all 5) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ALS2CL (see all 2) OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 3): ALS2CL (NM_147129)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for ALS2CL
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ALS2CL

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for ALS2CL
		Search LifeMap BioReagents cell lines for ALS2CL

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ALS2CL

Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005089	Rho guanyl-nucleotide exchange factor activity	IEA	--
GO:0005096	GTPase activator activity	IEA	--
GO:0005515	protein binding	--	--
GO:0017137	Rab GTPase binding	IEA	--
GO:0042802	identical protein binding	IPI	17239822

ALS2CL for ontologies About GeneDecksing

1 GenomeRNAi human phenotype for ALS2CL:

Decreased nuclei size in G2M

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for ALS2CL

STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

2 Interacting proteins for ALS2CL (Q60I27³ ENSP00000313670⁴) via UniProtKB, MINT, STRING, and/or I2D

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
RAB5A	P20339³, ENSP00000273047⁴	I2D: score=2 STRING: ENSP00000273047
UBC	ENSP00000344818⁴	STRING: ENSP00000344818

About this table

Gene Ontology (GO): 3 biological process terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0007032	endosome organization	IGI	17239822
GO:0008104	protein localization	IEA	--
GO:0035023	regulation of Rho protein signal transduction	IEA	--

ALS2CL for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for ALS2CL

3 HMDB Compounds for ALS2CL About this table

Compound	Synonyms	CAS #	PubMed Ids
Guanosine diphosphate	5'-GDP (see all 10)	146-91-8	--
Guanosine monophosphate	5'-GMP (see all 14)	85-32-5	--
Guanosine triphosphate	5'-GTP (see all 10)	86-01-1	--

Search CenterWatch for drugs/clinical trials and news about ALS2CL / AL2CL

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for ALS2CL gene (3 alternative transcripts):

NM_001190707.1 NM_147129.3 NM_182775.2

Unigene Cluster for ALS2CL:

ALS2 C-terminal like

Hs.517937 [show with all ESTs]

Unigene Representative Sequence: CR627258

10 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000486301(uc003cpx.2 uc003cpy.2) ENST00000318962(uc003cpz.2 uc003cqa.2 uc003cqc.2 uc003cqb.2)

ENST00000434140 ENST00000415953 ENST00000383742 ENST00000431015 ENST00000450172

ENST00000423707 ENST00000498817 ENST00000473484

miRNA Products:		OriGene 3'-UTR Clone (see all 2): ALS2CL Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ALS2CL
		1 QIAGEN miScript miRNA Assays for microRNA that regulate ALS2CL:
		hsa-miR-491-5p
		SwitchGear 3'UTR luciferase reporter plasmid: ALS2CL 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ALS2CL (see all 4) OriGene shRNA RFP: ALS2CL OriGene siRNA: ALS2CL
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ALS2CL

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ALS2CL (see all 5) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ALS2CL (see all 2) OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 3): ALS2CL (NM_147129)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for ALS2CL
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ALS2CL

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ALS2CL Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat ALS2CL
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ALS2CL
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ALS2CL

Additional cDNA sequence:

AB107015.1 AK074118.1 AK092455.1 AK093844.1 AK097225.1 AK131270.1 AK131273.1 AL832132.1

BC042906.1 BC061883.1 BC075825.1 BC109233.1 CR627258.1 NR_033815.1

15 DOTS entries:

DT.100025982 DT.100757908 DT.100025981 DT.100025983 DT.100820858 DT.95286174 DT.95138296 DT.100820865

DT.95319784 DT.97780604 DT.100708557 DT.100801526 DT.120655719 DT.40287752 DT.99930587

24/100 AceView cDNA sequences (see all 100):

BU685010 AK092455 BM666636 CB127478 AX747555 AK131270 BI061592 AK126505

BQ045190 NM_182775 CB306746 AX748334 NM_147129 AA151264 BX386066 BQ926546

AI225005 AK093844 AA557247 NM_182774 CA310537 CB126816 AK074118 CA311924

GeneLoc Exon Structure

5/13 Alternative Splicing Database (ASD) splice patterns (SP) for ALS2CL (see all 13) About this scheme

ExUns:	1a	·	1b	·	1c	·	1d	^	2	^	3a	·	3b	^	4a	·	4b	^	5	^	6	^	7	^	8	^	9	^	10	^	11a	·	11b	^	12	^	13	^	14	^	15	^	16	^	17	^	18	^	19a	·	19b	^
SP1:							-																-																								-		-
SP2:							-																-																								-		-
SP3:																							-																								-		-
SP4:							-																-																								-		-
SP5:																							-																								-		-

ExUns:	20	^	21	^	22a	·	22b	^	23a	·	23b	^	24	^	25	^	26a	·	26b	^	27a	·	27b	^	28a	·	28b	·	28c	·	28d	·	28e	·	28f
SP1:																					-
SP2:					-																-
SP3:					-																-
SP4:																					-
SP5:																					-

ECgene alternative splicing isoforms for ALS2CL

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

ALS2CL expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CGATGCTGAC

About this image

ALS2CL expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

1 LifeMap In Vivo Development Anatomical Compartment/Cell

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Adipose

Interscapular Brown Adipose Depot

Adipose

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See ALS2CL Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for ALS2CL

SOURCE GeneReport for Unigene cluster: Hs.517937

UniProtKB/Swiss-Prot: AL2CL_HUMAN, Q60I27

Tissue specificity: Expressed in heart and kidney

SABiosciences Custom PCR Arrays for ALS2CL

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ALS2CL Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat ALS2CL
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ALS2CL
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ALS2CL

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ALS2CL

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for ALS2CL gene from 2/12 species (see all 12) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	ALS2CL¹	ALS2 C-terminal like	61.74(n) 55.95(a)		428401 XM_003640647.1 XP_003640695.1
lizard (Anolis carolinensis)	Reptilia	ALS2CL⁶	--	54(a)	1 ↔ 1	GL343449.1(386493-425949)

ENSEMBL Gene Tree for ALS2CL (if available)
TreeFam Gene Tree for ALS2CL (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for ALS2CL gene

JPH2² RSPH10B² JPH4² MORN4² JPH1² JPH3² RSPH10B2² MORN1²

RSPH1² ALS2² MORN3²

3 SIMAP similar genes for ALS2CL using alignment to 5 protein entries: AL2CL_HUMAN (see all proteins):

FLJ00189 MORN4 ALS2

ALS2CL for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 3 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs142759650^1,2		--	46710002(+)	`TGGGCC/TGTGTC`	4	--	ds500¹		0	--	--	--	--
rs147254259^1,2		--	46710024(+)	`CTCTCC/TACTCT`	4	--	ds500¹		0	--	--	--	--
rs75463886^1,2	C	--	46710051(+)	`AAGTGC/TCATTT`	4	--	ds500¹		0	--	--	--	--
rs939413^1,2	C,F,H,	--	46710098(+)	`TCACCG/ACTGAA`	4	--	ds500¹		28		NA NS EA WA CSA	2210
rs939415^1,2	C,H,	--	46710162(+)	`GAGCTG/AGGCCC`	4	--	ds500¹		15		MN NS EA NA WA CSA	854
rs141000676^1,2		--	46710173(+)	`TGCCAA/GGCTGC`	4	--	ds500¹		0	--	--	--	--
rs144972345^1,2		--	46710274(+)	`GCCAGA/GGGCTC`	4	--	ds500¹		0	--	--	--	--
rs147927814^1,2		--	46710291(+)	`CAGCTA/GGGAGA`	4	--	ds500¹		0	--	--	--	--
rs3930202^1,2	C,F,H,	--	46710372(+)	`TACAGG/CAAGGA`	4	--	ds500¹		17		NS EA NA WA CSA	693
rs190498068^1,2		--	46710520(+)	`TATTTG/TTATTT`	4	--	ut3¹ nc-transcript-variant		0	--	--	--	--

HapMap Linkage Disequilibrium report for ALS2CL (46710485 - 46735194 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 4 variations for ALS2CL
4 CNVs: 31104 51105 51104 3428
Human Gene Mutation Database (HGMD): ALS2CL

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ALS2CL

DNA2.0 Custom Variant and Variant Library Synthesis for ALS2CL

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

ALS2CL for disorders           About GeneDecksing

OMIM gene information: 612402    OMIM disorders: --

5 diseases for ALS2CL:    About MalaCards

blepharitis squamous cell carcinoma pneumonia carcinoma

malaria

1 disease from the University of Copenhagen DISEASES database for ALS2CL:

Blepharitis

Export disorders for ALS2CL gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for ALS2CL gene, integrated from 9 sources (see all 13):
(articles sorted by number of sources associating them with ALS2CL)

Utopia: connect your pdf to the dynamic
world of online information

ALS2CL, a novel ALS2-interactor, modulates ALS2-mediated endosome dynamics. (PubMed id 17239822)^{1, 2, 3} Suzuki-Utsunomiya K.... Ikeda J.-E. (2007)
ALS2CL, the novel protein highly homologous to the carboxy-terminal half of ALS2, binds to Rab5 and modulates endosome dynamics. (PubMed id 15388334)^{1, 2, 3} Hadano S.... Ikeda J.-E. (2004)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (2004)
Normalization and subtraction: two approaches to facilitate gene discovery. (PubMed id 8889548)^{1, 3} Bonaldo M.F.... Soares M.B. (1996)
Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)¹ Kim W....Gygi S.P. (2011)
Multiple tumor-suppressor genes on chromosome 3p cont ribute to head and neck squamous cell carcinoma tumorigenesis. (PubMed id 20657180)¹ Lee D.J....Su G.H. (2010)
The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)² Bechtel S.... Schupp I. (2007)
The consensus coding sequences of human breast and colorectal cancers. (PubMed id 16959974)² Sjoeblom T.... Velculescu V.E. (2006)
The DNA sequence, annotation and analysis of human chromosome 3. (PubMed id 16641997)² Muzny D.M....Gibbs R.A. (2006)
Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)¹ Kimura K.... Sugano S. (2006)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 259173	HGNC: 20605	AceView: ALS2CL	Ensembl:ENSG00000178038	euGenes: HUgn259173
ECgene: ALS2CL	H-InvDB: ALS2CL

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for ALS2CL	Pharmacogenomics, SNPs, Pathways

Intellectual Property for ALS2CL gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for ALS2CL gene:
Search GeneIP for patents involving ALS2CL

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section


	EMD Millipore Custom Antibody & Bulk Services
	EMD Millipore Preclinical / Clinical Development Services
	EMD Millipore Immunoassay Services
	EMD Millipore Target Screening & Profiling Services

	Browse Antibodies		Browse Cell Culture Products
	Browse ELISAs		Browse Flow Cytometry Kits
	Browse Primer Pairs		Browse Kinase Activity Assays/Reagents
	Browse ELISpot Kits/Development Modules		Browse TFB/Immunoprecipitation Assays
	Browse Apoptosis Detection Kits/Reagents		Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents
	Browse DNA Damage/Repair Kits/Reagents		Browse Multiplex/Array Assay Kits/Reagents
	Browse Cell Selection/Detection Kits/Reagents		Browse Secondary Antibodies/Controls/Staining Reagents
	Browse Phosphatase Activity Assays/Reagents		Browse Recombinant/Natural Proteins

	Browse OriGene Antibodies		OriGene shRNA RFP for ALS2CL
	OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ALS2CL		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ALS2CL
	OriGene Protein Over-expression Lysate for ALS2CL		Browse OriGene Fluorogenic Cell Assay Kits
	OriGene siRNA for ALS2CL		OriGene 3'-UTR Clone for ALS2CL
	OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ALS2CL		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ALS2CL
	Browse OriGene GFP tagged cDNA clones in CMV expression vector		Browse OriGene MicroRNA Expression Plasmids
	Browse OriGene basic RS shRNAs		Browse OriGene validated miRNA SYBR primer pairs
	OriGene Purified Protein for ALS2CL		OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
	OriGene Custom Antibody Services for ALS2CL		OriGene Custom Protein Services for ALS2CL
	OriGene Custom Immunoassay Development

	QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat ALS2CL
	QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ALS2CL
	QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ALS2CL
	QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ALS2CL
	QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ALS2CL
	QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ALS2CL

	GenScript Custom Purified and Recombinant Proteins Services for ALS2CL		GenScript cDNA clones with any tag delivered in your preferred vector for ALS2CL
	GenScript Custom Assay Services for ALS2CL		GenScript Custom Superior Antibodies Services for ALS2CL
	GenScript Custom overexpressing Cell Line Services for ALS2CL		CloneReady with Over 120,000 Genes
	Gene Synthesis: Any Gene in Any Vector		Vector-based siRNA and miRNA, Ready for Transfection
	Gene Mutant Library, Variants up to 10^11		Plasmid Preparation
	Custom Peptide Services

Search for Antibodies & Assays

	Regulatory tfbs in ALS2CL promoter
	Search Chromatin IP Primers for ALS2CL
	RT² qPCR Primer Assay in human, mouse, rat ALS2CL
	Search GNC Networks for ALS2CL
	SABiosciences Custom PCR Arrays for ALS2CL

Search Tocris compounds for ALS2CL

	Browse Sino Biological Proteins and Antibodies
	Browse Sino Biological cDNA Clones
	Antibodies/Proteins Production Services
	Rabbit Monoclonal Antibody Platform
	Bulk Purchasing

Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

	Novus Tissue Slides
	ALS2CL antibodies
	ALS2CL proteins
	ALS2CL lysates

	Search for Antibodies for ALS2CL at Abcam
	See all of Abcam's Antibodies, Kits and Proteins for ALS2CL
	Custom Antibody / Protein Production Service
	Bulk Purchasing
	Advantages of Rabbit Monoclonal antibodies
	Abcam protocols and scientific support

Browse ProSpec Recombinant Proteins

ALS2CL Proteins, Antibodies, CLIAs, and ELISAs

Search LifeMap BioReagents cell lines for ALS2CL

	Gene Synthesis
	Protein Engineering
	Variant Library Synthesis
	Codon Optimization
	Protein Production and Purification

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ALS2CL

	SwitchGear 3'UTR luciferase reporter plasmids for ALS2CL
	SwitchGear Promoter luciferase reporter plasmids for ALS2CL

Search ThermoFisher Antibodies for ALS2CL

Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ALS2CL

GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

View Random Gene

Category			VWF (GIFTS: 73) von Willebrand factor
GIFtS Group

The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes Disease genes ALS2CL gene at Home site.

hostname: 356977-web1.xennexinc.com index build: 100 solr: 1.4

Advanced Search

Export list of displayed genes

ALS2CL Gene

ALS2 C-terminal like

Aliases
for ALS2CL gene

Summaries
for ALS2CL gene

Genomic Views
for ALS2CL gene

Proteins
for ALS2CL gene

Protein Domains /
Families
for ALS2CL gene

Function
for ALS2CL gene

Pathways & Interactions
for ALS2CL gene

Drugs & Compounds
for ALS2CL gene

Transcripts
for ALS2CL gene

Expression
for ALS2CL gene

Orthologs
for ALS2CL gene

Paralogs
for ALS2CL gene

Genomic Variants
for ALS2CL gene

Disorders / Diseases
for ALS2CL gene

Publications
for ALS2CL gene

External Searches for ALS2CL gene

Genome Databases showing ALS2CL gene

Other Databases showing ALS2CL gene

Specialized Databases showing ALS2CL gene

Intellectual Property
for ALS2CL gene

Products
for ALS2CL gene

View Random Gene

Advanced Search

Export list of displayed genes

ALS2CL Gene

ALS2 C-terminal like

Aliasesfor ALS2CL gene

Summariesfor ALS2CL gene

Genomic Viewsfor ALS2CL gene

Proteinsfor ALS2CL gene

Protein Domains /Familiesfor ALS2CL gene

Functionfor ALS2CL gene

Pathways & Interactionsfor ALS2CL gene

Drugs & Compoundsfor ALS2CL gene

Transcriptsfor ALS2CL gene

Expression for ALS2CL gene

Orthologsfor ALS2CL gene

Paralogsfor ALS2CL gene

Genomic Variantsfor ALS2CL gene

Disorders / Diseasesfor ALS2CL gene

Publicationsfor ALS2CL gene

External Searches for ALS2CL gene

Genome Databases showing ALS2CL gene

Other Databases showing ALS2CL gene

Specialized Databases showing ALS2CL gene

Intellectual Propertyfor ALS2CL gene

Productsfor ALS2CL gene

View Random Gene

Aliases
for ALS2CL gene

Summaries
for ALS2CL gene

Genomic Views
for ALS2CL gene

Proteins
for ALS2CL gene

Protein Domains /
Families
for ALS2CL gene

Function
for ALS2CL gene

Pathways & Interactions
for ALS2CL gene

Drugs & Compounds
for ALS2CL gene

Transcripts
for ALS2CL gene

Expression
for ALS2CL gene

Orthologs
for ALS2CL gene

Paralogs
for ALS2CL gene

Genomic Variants
for ALS2CL gene

Disorders / Diseases
for ALS2CL gene

Publications
for ALS2CL gene

Intellectual Property
for ALS2CL gene

Products
for ALS2CL gene