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Aliases for ALPPL2 Gene

Aliases for ALPPL2 Gene

  • Alkaline Phosphatase, Placental-Like 2 2 3
  • Alkaline Phosphatase Nagao Isozyme 3 4
  • Germ Cell Alkaline Phosphatase 3 4
  • EC 4 63
  • ALP-1 3 4
  • ALPPL 3 4
  • GCAP 3 4
  • Testicular And Thymus Alkaline Phosphatase 3
  • Placental-Like Alkaline Phosphatase 3
  • Placental Alkaline Phosphatase-Like 4
  • Nagao Isozyme 3
  • PLAP-Like 4
  • ALPG 3

External Ids for ALPPL2 Gene

Previous GeneCards Identifiers for ALPPL2 Gene

  • GC02P231328
  • GC02P232001
  • GC02P233235
  • GC02P233474
  • GC02P233097
  • GC02P232979
  • GC02P233273
  • GC02P225122

Summaries for ALPPL2 Gene

Entrez Gene Summary for ALPPL2 Gene

  • There are at least four distinct but related alkaline phosphatases: intestinal, placental, placental-like, and liver/bone/kidney (tissue non-specific). The product of this gene is a membrane bound glycosylated enzyme, localized to testis, thymus and certain germ cell tumors, that is closely related to both the placental and intestinal forms of alkaline phosphatase. [provided by RefSeq, Jul 2008]

GeneCards Summary for ALPPL2 Gene

ALPPL2 (Alkaline Phosphatase, Placental-Like 2) is a Protein Coding gene. Diseases associated with ALPPL2 include submandibular adenitis and kidney osteogenic sarcoma. Among its related pathways are Metabolism and NAD metabolism. GO annotations related to this gene include phosphatase activity and alkaline phosphatase activity. An important paralog of this gene is ALPL.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ALPPL2 Gene

Genomics for ALPPL2 Gene

Regulatory Elements for ALPPL2 Gene

Genomic Location for ALPPL2 Gene

232,406,842 bp from pter
232,410,714 bp from pter
3,873 bases
Plus strand

Genomic View for ALPPL2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ALPPL2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ALPPL2 Gene

Proteins for ALPPL2 Gene

  • Protein details for ALPPL2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Alkaline phosphatase, placental-like
    Protein Accession:
    Secondary Accessions:
    • A8KAF2
    • Q16727
    • Q53S81
    • Q96CM1

    Protein attributes for ALPPL2 Gene

    532 amino acids
    Molecular mass:
    57377 Da
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Note=Binds 1 Mg(2+) ion.;
    Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Note=Binds 2 Zn(2+) ions.;
    Quaternary structure:
    • Homodimer
    • In most mammals there are four different isozymes: placental, placental-like, intestinal and tissue non-specific (liver/bone/kidney)
    • Sequence=CAA30232.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

neXtProt entry for ALPPL2 Gene

Proteomics data for ALPPL2 Gene at MOPED

Post-translational modifications for ALPPL2 Gene

  • Glycosylation at Asn 141 and Asn 268
  • Modification sites at PhosphoSitePlus

Other Protein References for ALPPL2 Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains & Families for ALPPL2 Gene

Gene Families for ALPPL2 Gene

Suggested Antigen Peptide Sequences for ALPPL2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the alkaline phosphatase family.
  • Belongs to the alkaline phosphatase family.
genes like me logo Genes that share domains with ALPPL2: view

Function for ALPPL2 Gene

Molecular function for ALPPL2 Gene

GENATLAS Biochemistry:
phosphatase alkaline,placental-like 2
UniProtKB/Swiss-Prot CatalyticActivity:
A phosphate monoester + H(2)O = an alcohol + phosphate.

Enzyme Numbers (IUBMB) for ALPPL2 Gene

Gene Ontology (GO) - Molecular Function for ALPPL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003824 catalytic activity --
GO:0004035 alkaline phosphatase activity NAS 2162249
GO:0016791 phosphatase activity --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ALPPL2: view
genes like me logo Genes that share phenotypes with ALPPL2: view

Animal Model Products

CRISPR Products

miRNA for ALPPL2 Gene

miRTarBase miRNAs that target ALPPL2

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ALPPL2

In Situ Assay Products

Flow Cytometry Products

No data available for Animal Models , Transcription Factor Targets and HOMER Transcription for ALPPL2 Gene

Localization for ALPPL2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ALPPL2 Gene

Cell membrane; Lipid-anchor, GPI-anchor.

Subcellular locations from

Jensen Localization Image for ALPPL2 Gene COMPARTMENTS Subcellular localization image for ALPPL2 gene
Compartment Confidence
plasma membrane 5
cytoskeleton 3
cytosol 3
extracellular 3
nucleus 3
vacuole 3
endoplasmic reticulum 2
golgi apparatus 2
lysosome 2
mitochondrion 2
peroxisome 2
endosome 1

Gene Ontology (GO) - Cellular Components for ALPPL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IEA --
GO:0031225 anchored component of membrane IEA --
genes like me logo Genes that share ontologies with ALPPL2: view

Pathways & Interactions for ALPPL2 Gene

genes like me logo Genes that share pathways with ALPPL2: view

Pathways by source for ALPPL2 Gene

2 KEGG pathways for ALPPL2 Gene
1 GeneGo (Thomson Reuters) pathway for ALPPL2 Gene

Gene Ontology (GO) - Biological Process for ALPPL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006470 protein dephosphorylation --
GO:0008152 metabolic process --
GO:0016311 dephosphorylation NAS 2162249
genes like me logo Genes that share ontologies with ALPPL2: view

No data available for SIGNOR curated interactions for ALPPL2 Gene

Drugs & Compounds for ALPPL2 Gene

(12) Drugs for ALPPL2 Gene - From: HMDB, NovoSeek, FDA Approved Drugs, DrugBank, and DGIdb

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Amifostine Approved, Investigational Pharma Target, inducer 81
Ethyol Approved December 8, 1995 Pharma 0
1-Butanol Experimental Pharma 0
1-Proponol Experimental Pharma 0
4-Nitrophenol Experimental Pharma 0

(14) Additional Compounds for ALPPL2 Gene - From: HMDB and NovoSeek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
  • 1-Hexanol
  • 1-Hexyl alcohol
  • 1-Hydroxyhexane
  • Alcohol C-6
  • Alcohol(C6)
  • 1-Pentanol
  • 1-Pentol
  • 1-Pentyl alcohol
  • Alcool amylique
  • Alcool amylique (french)
dihydroneopterin triphosphate
  • 2-Amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl) dihydropteridine triphosphate
  • 6-(L-Erythro-1,2-Dihydroxypropyl 3-triphosphate)-7,8-dihydropterin
  • 6-[(1S,2R)-1,2-Dihydroxy-3-triphosphooxypropyl]-7,8-dihydropterin
  • 7,8-Dihydroneopterin 3'-triphosphate
  • 7,8-Dihydroneopterin triphosphate
Dihydroxyacetone phosphate
  • 1,3-Dihydroxy-2-Propanone mono(dihydrogen phosphate)
  • 1,3-Dihydroxy-2-propanone phosphate
  • 1,3-Dihydroxyacetone 1-phosphate
  • 1-Hydroxy-3-(phosphonooxy)-2-Propanone
  • 1-Hydroxy-3-(phosphonooxy)acetone
  • 1-Hydroxymethylpropane
  • 2-Methyl propanol
  • 2-Methyl-1-propanol
  • 2-Methyl-1-propanyl alcohol
  • 2-Methylpropan-1-ol
genes like me logo Genes that share compounds with ALPPL2: view

Transcripts for ALPPL2 Gene

mRNA/cDNA for ALPPL2 Gene

(1) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(152) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ALPPL2 Gene

Alkaline phosphatase, placental-like 2:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ALPPL2

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ALPPL2 Gene

No ASD Table

Relevant External Links for ALPPL2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ALPPL2 Gene

mRNA expression in normal human tissues for ALPPL2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ALPPL2 Gene

This gene is overexpressed in Colon - Transverse (x10.4), Lung (x9.7), Testis (x9.6), Fallopian Tube (x7.4), and Cervix - Endocervix (x5.3).

Protein differential expression in normal tissues from HIPED for ALPPL2 Gene

This gene is overexpressed in Fetal ovary (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ALPPL2 Gene

SOURCE GeneReport for Unigene cluster for ALPPL2 Gene Hs.333509

mRNA Expression by UniProt/SwissProt for ALPPL2 Gene

Tissue specificity: Trace amounts in the testis and thymus, and in elevated amounts in germ cell tumors
genes like me logo Genes that share expression patterns with ALPPL2: view

Protein tissue co-expression partners for ALPPL2 Gene

Primer Products

In Situ Assay Products

Orthologs for ALPPL2 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for ALPPL2 Gene

Organism Taxonomy Gene Similarity Type Details
(Mus musculus)
Mammalia Alppl2 35
  • 78.19 (n)
  • 76.89 (a)
Akp3 36
  • 69 (a)
Alpi 36
  • 70 (a)
Alppl2 36
  • 74 (a)
(Pan troglodytes)
Mammalia ALPPL2 35
  • 99.06 (n)
  • 99.44 (a)
  • 99 (a)
(Rattus norvegicus)
Mammalia Alpp 35
  • 77.51 (n)
  • 75.87 (a)
(Bos Taurus)
Mammalia -- 36
  • 76 (a)
-- 36
  • 77 (a)
-- 36
  • 73 (a)
-- 36
  • 73 (a)
(Canis familiaris)
Mammalia -- 36
  • 72 (a)
(Monodelphis domestica)
Mammalia -- 36
  • 70 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 72 (a)
(Gallus gallus)
Aves -- 36
  • 64 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 60 (a)
(Danio rerio)
Actinopterygii alpi.2 36
  • 55 (a)
fruit fly
(Drosophila melanogaster)
Insecta Aph-4 37
  • 44 (a)
CG10592 37
  • 42 (a)
CG10827 37
  • 43 (a)
CG16771 37
  • 38 (a)
CG1809 37
  • 43 (a)
CG3264 37
  • 42 (a)
CG3290 37
  • 42 (a)
CG3292 37
  • 41 (a)
CG5150 37
  • 42 (a)
CG5656 37
  • 44 (a)
CG8105 37
  • 39 (a)
CG3290 35
  • 52.65 (n)
  • 46.24 (a)
Aph-4 36
  • 32 (a)
CG10592 36
  • 34 (a)
CG10827 36
  • 35 (a)
CG16771 36
  • 27 (a)
CG1809 36
  • 37 (a)
CG3264 36
  • 34 (a)
CG3290 36
  • 33 (a)
CG3292 36
  • 33 (a)
CG5150 36
  • 36 (a)
CG5361 36
  • 22 (a)
CG5656 36
  • 37 (a)
CG8105 36
  • 35 (a)
CG8147 36
  • 34 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes PHO8 36
  • 21 (a)
PHO8 38
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 40 (a)
-- 36
  • 38 (a)
-- 36
  • 39 (a)
CSA.180 36
  • 38 (a)
CSA.4362 36
  • 37 (a)
Species with no ortholog for ALPPL2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ALPPL2 Gene

Gene Tree for ALPPL2 (if available)
Gene Tree for ALPPL2 (if available)

Paralogs for ALPPL2 Gene

Paralogs for ALPPL2 Gene

(3) SIMAP similar genes for ALPPL2 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with ALPPL2: view

Variants for ALPPL2 Gene

Sequence variations from dbSNP and Humsavar for ALPPL2 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs1009934 -- 232,410,170(+) CATAT(C/G)CTGAG utr-variant-3-prime
rs1048986 -- 232,407,939(+) TCGGA(C/T)GCCGA synonymous-codon, reference
rs1048987 -- 232,407,987(+) ATCGC(C/T)ACGCA reference, synonymous-codon
rs1048995 -- 232,409,799(+) GGGGC(C/G/T)GTCCG reference, missense
rs1048997 -- 232,409,833(+) CTGGC(A/C)GGGAC reference, synonymous-codon

Structural Variations from Database of Genomic Variants (DGV) for ALPPL2 Gene

Variant ID Type Subtype PubMed ID
nsv522450 CNV Loss 19592680
esv34493 CNV Gain 17911159
nsv821918 CNV Gain 20364138
nsv875977 CNV Loss 21882294
dgv675e201 CNV Deletion 23290073
dgv4449n71 CNV Gain 21882294
nsv875979 CNV Gain 21882294
esv2659833 CNV Deletion 23128226
dgv493n27 CNV Loss 19166990
dgv4450n71 CNV Loss 21882294
dgv4451n71 CNV Gain+Loss 21882294
dgv494n27 CNV Gain 19166990
nsv436293 CNV Deletion 17901297
dgv1294e1 CNV Complex 17122850
nsv521461 CNV Loss 19592680
nsv875992 CNV Gain 21882294
nsv875994 CNV Gain 21882294
dgv4452n71 CNV Gain 21882294
nsv518263 CNV Loss 19592680
nsv875998 CNV Loss 21882294
nsv482058 CNV Gain 20164927

Variation tolerance for ALPPL2 Gene

Residual Variation Intolerance Score: 91.92% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.54; 64.83% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ALPPL2 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ALPPL2 Gene

Disorders for ALPPL2 Gene

MalaCards: The human disease database

(65) MalaCards diseases for ALPPL2 Gene - From: DISEASES, NovoSeek, and GeneCards

Disorder Aliases PubMed IDs
submandibular adenitis
  • submandibular lymphadenitis
kidney osteogenic sarcoma
  • renal osteogenic sarcoma
cervix erosion
  • erosion of cervix
foster-kennedy syndrome
  • optic nerve diseases
soft palate cancer
  • malignant tumor of soft palate
- elite association

Relevant External Links for ALPPL2

Genetic Association Database (GAD)
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with ALPPL2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ALPPL2 Gene

Publications for ALPPL2 Gene

  1. New advances in clinical biomarkers in testis cancer. (PMID: 20036893) Favilla V. … Morgia G. (Front Biosci (Elite Ed) 2010) 23 67
  2. Less advanced testicular dysgenesis is associated by a higher prevalence of germ cell neoplasia. (PMID: 19719533) Guminska A. … Slowikowska-Hilczer J. (Int. J. Androl. 2010) 23 67
  3. Epithelioid angiosarcoma: a neoplasm with potential diagnostic challenges. (PMID: 19813270) Lin C.F. … Lin X. (Diagn. Cytopathol. 2010) 23 67
  4. Pleomorphic rhabdomyosarcoma of the uterine corpus: a clinicopathologic study of 4 cases and a review of the literature. (PMID: 20173498) Fadare O. … Parkash V. (Int. J. Gynecol. Pathol. 2010) 23 67
  5. Diagnostic utility of SALL4 in extragonadal yolk sac tumors: an immunohistochemical study of 59 cases with comparison to placental-like alkaline phosphatase, alpha-fetoprotein, and glypican-3. (PMID: 19574883) Wang F. … Cao D. (Am. J. Surg. Pathol. 2009) 23 67

Products for ALPPL2 Gene

Sources for ALPPL2 Gene

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