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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ALPPL2 Gene

protein-coding   GIFtS: 65
GCID: GC02P233273

Alkaline Phosphatase, Placental-Like 2

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Alkaline Phosphatase, Placental-Like 21 2     ALPG2
Alkaline Phosphatase Nagao Isozyme2 3     Alkaline Phosphatase, Placental-Like2
Germ Cell Alkaline Phosphatase2 3     Nagao Isozyme2
ALP-12 3     Placental-Like Alkaline Phosphatase2
ALPPL2 3     Testicular And Thymus Alkaline Phosphatase2
GCAP2 3     PLAP-like3
EC 3.1.3.13 8     Placental Alkaline Phosphatase-Like3

External Ids:    HGNC: 4411   Entrez Gene: 2512   Ensembl: ENSG000001632867   OMIM: 1718105   UniProtKB: P106963   

Export aliases for ALPPL2 gene to outside databases

Previous GC identifers: GC02P231328 GC02P232001 GC02P233235 GC02P233474 GC02P233097 GC02P232979 GC02P225122


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for ALPPL2 Gene:
There are at least four distinct but related alkaline phosphatases: intestinal, placental, placental-like, and
liver/bone/kidney (tissue non-specific). The product of this gene is a membrane bound glycosylated enzyme,
localized to testis, thymus and certain germ cell tumors, that is closely related to both the placental and
intestinal forms of alkaline phosphatase. (provided by RefSeq, Jul 2008)

GeneCards Summary for ALPPL2 Gene: 
ALPPL2 (alkaline phosphatase, placental-like 2) is a protein-coding gene. Diseases associated with ALPPL2 include bile duct disease, and seminoma, and among its related super-pathways are Nicotinate and nicotinamide metabolism and Metabolism. GO annotations related to this gene include alkaline phosphatase activity and metal ion binding. An important paralog of this gene is ALPL.




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000002.11  NC_018913.2  NT_005403.17  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ALPPL2 gene promoter:
         NF-1/L   NF-1   GATA-3   GCNF   NCX/Ncx   AP-2gamma   AP-2beta   AP-2alpha   AP-2alphaA   ATF   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidALPPL2 promoter sequence
   Search SABiosciences Chromatin IP Primers for ALPPL2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ALPPL2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q37   Ensembl cytogenetic band:  2q37.1   HGNC cytogenetic band: 2q37

ALPPL2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ALPPL2 gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02P233273:  view genomic region     (about GC identifiers)

Start:
233,271,552 bp from pter      End:
233,275,424 bp from pter
Size:
3,873 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: PPBN_HUMAN, P10696 (See protein sequence)
Recommended Name: Alkaline phosphatase, placental-like precursor  
Size: 532 amino acids; 57377 Da
Cofactor: Binds 1 magnesium ion (By similarity)
Cofactor: Binds 2 zinc ions (By similarity)
Subunit: Homodimer
Subcellular location: Cell membrane; Lipid-anchor, GPI-anchor
Miscellaneous: In most mammals there are four different isozymes: placental, placental-like, intestinal and tissue
non-specific (liver/bone/kidney)
Sequence caution: Sequence=CAA30232.1; Type=Erroneous gene model prediction;
Secondary accessions: A8KAF2 Q16727 Q53S81 Q96CM1

Explore the universe of human proteins at neXtProt for ALPPL2: NX_P10696

Explore proteomics data for ALPPL2 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P10696

  • 4/17 DME Specific Peptides for ALPPL2 (P10696) (see all 17)
     TTRGNEV  VEGGRID  NLVQEWL  GVVTTTR 

    ALPPL2 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    ALPPL2 Protein Expression
    REFSEQ proteins: NP_112603.2  
    ENSEMBL proteins: 
     ENSP00000295453  

    Human Recombinant Protein Products for ALPPL2: 
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    Novus Biologicals ALPPL2 Proteins
    Novus Biologicals ALPPL2 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for ALPPL2 

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane IEA--
    GO:0016020membrane NAS--
    GO:0031225anchored to membrane IEA--

    ALPPL2 for ontologies           About GeneDecksing



    ALPPL2 Antibody Products: 
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    Assay Products for ALPPL2: 
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    Cloud-Clone Corp. ELISAs for ALPPL2 
    Cloud-Clone Corp. CLIAs for ALPPL2


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    4 InterPro protein domains:
     IPR001952 Alkaline_phosphatase
     IPR017849 Alkaline_Pase-like_a/b/a
     IPR017850 Alkaline_phosphatase_core
     IPR018299 Alkaline_phosphatase_AS

    Graphical View of Domain Structure for InterPro Entry P10696

    ProtoNet protein and cluster: P10696

    1 Blocks protein domain: IPB001952 Alkaline phosphatase

    UniProtKB/Swiss-Prot: PPBN_HUMAN, P10696
    Similarity: Belongs to the alkaline phosphatase family


    ALPPL2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: PPBN_HUMAN, P10696
    Catalytic activity: A phosphate monoester + H(2)O = an alcohol + phosphate

         Genatlas biochemistry entry for ALPPL2:
    phosphatase alkaline,placental-like 2

         Enzyme Number (IUBMB): EC 3.1.3.11 2

         Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003824catalytic activity ----
    GO:0004035alkaline phosphatase activity NAS2162249
    GO:0016791phosphatase activity ----
    GO:0046872metal ion binding IEA--
         
    ALPPL2 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for ALPPL2:
     Decreased Salmonella enterica   Decreased Salmonella enterica  

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for ALPPL2 
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for ALPPL2 
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    miRNA
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    Inhib. RNA
    Products:
        
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ALPPL2


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for ALPPL2 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1NAD metabolism
    NAD metabolism0.43
    2Metabolism
    Metabolic pathways0.40
    3Folate biosynthesis
    Folate biosynthesis

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 EMD Millipore Pathway for ALPPL2
        NAD metabolism


    1 GeneGo (Thomson Reuters) Pathway for ALPPL2
        NAD metabolism


    2         Kegg Pathways  (Kegg details for ALPPL2):
        Folate biosynthesis
    Metabolic pathways


    ALPPL2 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ALPPL2

    STRING Interaction Network Preview (showing 3 interactants - click image to see more details)

    5/12 Interacting proteins for ALPPL2 (P106963 ENSP000002954534) via UniProtKB, MINT, STRING, and/or I2D (see all 12)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ALPPP051873, ENSP000003758814I2D: score=1 STRING: ENSP00000375881
    ALPLP051863I2D: score=1 
    AP3D1O146173I2D: score=1 
    CNDP2Q96KP43I2D: score=1 
    MLST8Q9BVC43I2D: score=1 
    About this table

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008152metabolic process ----
    GO:0016310phosphorylation NAS--

    ALPPL2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    ALPPL2 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ALPPL2 (PPBN)

    10/15 HMDB Compounds for ALPPL2 (see all 15)    About this table
    CompoundSynonyms CAS #PubMed Ids
    1-Butanol1-Butanol (see all 10)71-36-3--
    1-Hexanol1-Hexyl alcohol (see all 30)111-27-3--
    1-Pentanol1-Pentol (see all 34)71-41-0--
    4-Nitrophenol1-Hydroxy-4-nitrobenzene (see all 8)100-02-7--
    7,8-Dihydroneopterin2-Amino-4-hydroxy-6-(D-erythro-1',2',3'-trihydroxypropyl)-7,8-dihydropteridine (see all 11)1218-98-0--
    Dihydroneopterin triphosphate2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl) dihydropteridine triphosphate (see all 5)20574-65-6--
    Dihydroxyacetone1,3-Dihydroxy-2-propanone (see all 21)96-26-4--
    Dihydroxyacetone phosphate1,3-Dihydroxy-2-propanone phosphate (see all 17)57-04-5--
    Ethanol1-Hydroxyethane (see all 57)64-17-5--
    Isobutanol1-Hydroxymethylpropane (see all 18)78-83-1--

    2 DrugBank Compounds for ALPPL2    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Levamisoledl-Tetramisol (see all 7)14769-73-4targetinhibitor10951365 12615144 18719742 11403767 11304750 11850443
    AmifostineAmifostine Ethiofos (see all 7)20537-88-6targetinducer10348255 10553165 10995012 10523712 10628381

    7 Novoseek inferred chemical compound relationships for ALPPL2 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    rsai 48.3 1 7914510 (1)
    butyrate 38.1 8 7504459 (4), 2009524 (2), 11361139 (1), 1596896 (1)
    vas-a 33.7 1 16927637 (1)
    paraffin 25.8 4 15597196 (1), 11374842 (1), 18292827 (1)
    leucine 21.7 1 1939159 (1)
    cyclic amp 1.61 8 7504459 (5)
    polysaccharide 0 4 1554693 (1), 2009524 (1)

    Search CenterWatch for drugs/clinical trials and news about ALPPL2 / PPBN

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for ALPPL2 gene: 
    NM_031313.2  

    Unigene Cluster for ALPPL2:

    Alkaline phosphatase, placental-like 2
    Hs.333509  [show with all ESTs]
    Unigene Representative Sequence: NM_031313
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000295453(uc002vss.4)
    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ALPPL2
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    Inhib. RNA
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    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ALPPL2
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ALPPL2
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    Additional mRNA sequence: 

    AB012642.1 BC014139.2 J04948.1 X53279.1 X55958.1 

    3 DOTS entries:

    DT.75100605  DT.95102727  DT.87016630 

    24/152 AceView cDNA sequences (see all 152):

    AL553983 CR621490 BM742455 R31098 BM744140 AL553521 BX095665 BM742176 
    CR599162 AF217992 BC068501 AL554586 BX439339 M14169 M13077 T29404 
    CB989365 BC009647 J04948 R31392 BV183442 M12551 R71624 R64691 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ALPPL2 expression in normal human tissues (normalized intensities)      ALPPL2 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GATTTCTCAG
    ALPPL2 Expression
    About this image


    ALPPL2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/3 selected tissues (see all 3) fully expand
     
     Trophoblast (Extraembryonic Tissues)
             Mural Trophectoderm Cells Mural Trophectoderm
     
     Blood (Hematopoietic System)
             reticulocytes   
     
     Placenta (Extraembryonic Tissues)

    See ALPPL2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ALPPL2

    SOURCE GeneReport for Unigene cluster: Hs.333509

    UniProtKB/Swiss-Prot: PPBN_HUMAN, P10696
    Tissue specificity: Trace amounts in the testis and thymus, and in elevated amounts in germ cell tumors

        SABiosciences Custom PCR Arrays for ALPPL2
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ALPPL2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals and fungi.

    Orthologs for ALPPL2 gene from 6/13 species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Alpi1 alkaline phosphatase, intestinal 77.38(n)
    75.43(a)
      76768  NM_001081082.2  NP_001074551.1 
    chicken
    (Gallus gallus)
    Aves --
    --
    --
    65(a)
    56(a)
    1 ↔ many
    possible ortholog
    9(15043911-15046938)
    9(15040804-15043296)
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    (see all 3)
    Alkaline phosphatase
    (see all 3)
    64(a)
    60(a)
    (see all 3)
    possible ortholog
    1 ↔ many
    (see all 3)
    AAWZ02040724(38-6154)
    GL343304.1(677973-694404)
    zebrafish
    (Danio rerio)
    Actinopterygii alpi.26
    alpi.16
    (see all 3)
    alkaline phosphatase, intestinal.1
    (see all 3)
    54(a)
    52(a)
    (see all 3)
    1 ↔ many
    possible ortholog
    (see all 3)
    22(41823911-41838077)
    22(41808075-41823295)
    fruit fly
    (Drosophila melanogaster)
    Insecta CG56563
    CG32641
    alkaline phosphatase3
    CG32641
    44(a)
    (best of 11)3
    52.32(n)1
    44.13(a)1
      78D23
    375401  NM_137811.21  NP_611655.11 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes PHO8(YDR481C)4 Repressible vacuolar alkaline phosphatase; regulated more   --   4(1420250-1418550) 852092  NP_010769.1 


    ENSEMBL Gene Tree for ALPPL2 (if available)
    TreeFam Gene Tree for ALPPL2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ALPPL2 gene
    ALPL2  ALPI2  ALPP2  
    3 SIMAP similar genes for ALPPL2 using alignment to 1 protein entry:     PPBN_HUMAN:
    ALPP    ALPI    ALPL

    ALPPL2 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/270 SNPs in ALPPL2 are shown (see all 270)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0275544
    ----see VAR_0275542 L R mis40--------
    VAR_0275524
    ----see VAR_0275522 Q E mis40--------
    rs1437956151,2
    --233269571(+) AAGTAA/GATTGC 1 -- us2k10--------
    rs26977671,2
    C,F--233269859(+) tctgtT/Cggcca 1 -- us2k14Minor allele frequency- C:0.43NA CSA 7
    rs1439626691,2
    --233269897(+) CTCACC/TGCAAG 1 -- us2k10--------
    rs1907684421,2
    --233269908(+) CTCCAC/TCTCCG 1 -- us2k10--------
    rs1823367431,2
    --233270051(+) CCTGAA/CCTTGT 1 -- us2k10--------
    rs1869540251,2
    --233270074(+) TCGGCC/TTCCCA 1 -- us2k10--------
    rs1142833101,2
    F--233270115(+) TGCCCG/AGCCTT 1 -- us2k11Minor allele frequency- A:0.06WA 118
    rs1902208961,2
    --233270144(+) AAAGGC/GCTTCC 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for ALPPL2 (233271552 - 233275424 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10/21 variations for ALPPL2 (see all 21):    About this table     
    Variant IDTypeSubtypePubMed ID
    dgv675e201CNV Deletion23290073
    esv2659833CNV Deletion23128226
    nsv436293CNV Deletion17901297
    nsv521461CNV Loss19592680
    dgv4450n71CNV Loss21882294
    nsv875977CNV Loss21882294
    nsv875998CNV Loss21882294
    nsv522450CNV Loss19592680
    nsv518263CNV Loss19592680
    dgv493n27CNV Loss19166990

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 171810    OMIM disorders: --

    20/63 diseases for ALPPL2 (see all 63):    About MalaCards
    bile duct disease    seminoma    gonadoblastoma    complete androgen insensitivity syndrome
    congenital lipoid adrenal hyperplasia    lipoid adrenal hyperplasia    osteitis fibrosa    germ cell tumors
    pleomorphic rhabdomyosarcoma    mediastinitis    enteropathica    acrodermatitis
    acrodermatitis enteropathica    gallbladder disease    hypersensitivity reaction type ii disease    osteonecrosis
    hypophosphatasia    cryptorchidism    osteosclerosis    dysgerminoma

    20/54 diseases from the University of Copenhagen DISEASES database for ALPPL2 (see all 54):
    Osteoporosis     Liver disease     Cholestasis     Hyperparathyroidism
    Osteomalacia     Hypophosphatasia     Cholangitis     Rickets
    Paget's disease of bone     Renal osteodystrophy     Hypercalcemia     Kidney failure
    Osteitis fibrosa     Hypersensitivity reaction type II disease     Seminoma     Choledocholithiasis
    Hypophosphatemia     Carcinoma     Breast cancer     Diarrhea

    ALPPL2 for disorders           About GeneDecksing

    10/13 Novoseek inferred disease relationships for ALPPL2 gene (see all 13)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    seminoma 87.2 18 1310437 (2), 2187297 (2), 16115909 (1), 16723857 (1) (see all 14)
    gonadoblastoma 78.6 1 15968543 (1)
    yolk sac tumor 69.2 2 7543237 (1), 19574883 (1)
    carcinoma embryonal 66 2 10547581 (1)
    choriocarcinoma 56.9 8 2009524 (3), 7504459 (2), 8314767 (2)
    embryonal tumor 55.7 1 16115909 (1)
    cryptorchidism 53.4 1 10869645 (1)
    germ cell cancer 50.3 1 11374808 (1)
    carcinoma 44.6 4 8514281 (1), 10323391 (1), 16163499 (1), 9190360 (1)
    tumors 44.1 21 10471538 (2), 11156214 (1), 15767804 (1), 17521702 (1) (see all 17)

    Genetic Association Database (GAD): ALPPL2

    Export disorders for ALPPL2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ALPPL2 gene, integrated from 9 sources (see all 144):
    (articles sorted by number of sources associating them with ALPPL2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular cloning of complementary DNAs encoding alkaline phosphatase in human colon cancer cells. (PubMed id 2297757)1, 2, 9 Gum J.R. Jr.... Kim Y.S. (1990)
    2. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)1, 2 Hillier L.W....Wilson R.K. (2005)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    4. Expression of a Nagao-type, phosphatidylinositol-glycan anchored alkaline phosphatase in human choriocarcinomas. (PubMed id 2162249)1, 2 Lowe M.E. and Strauss A.W. (1990)
    5. Expression of the germ cell alkaline phosphatase gene in human choriocarcinoma cells. (PubMed id 2745460)1, 2 Watanabe S.... Chou J.Y. (1989)
    6. Seminoma-derived Nagao isozyme is encoded by a germ-cell alkaline phosphatase gene. (PubMed id 2834730)1, 2 Millan J.L. and Manes T. (1988)
    7. 5' nucleotide sequence of a putative human placental alkaline phosphatase-like gene. (PubMed id 3387245)1, 2 Shen L.P.... Kam W. (1988)
    8. Two gene duplication events in the evolution of the human heat-stable alkaline phosphatases. (PubMed id 3443302)1, 2 Knoll B.J.... Longley M. (1987)
    9. Transcriptional regulation and the effects of sodium butyrate and glycosylation on catalytic activity of human germ cell alkaline phosphatase. (PubMed id 2009524)1, 9 Pan C.J....Chou J.Y. (1991)
    10. Germ cell alkaline phosphatase in human seminal plasma following vasectomy. (PubMed id 1581814)1, 9 Lewis-Jones D.I....McLaughlin P.J. (1992)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 251 HGNC: 441 AceView: ALPPandALPPL2 Ensembl:ENSG00000163286 euGenes: HUgn251
    ECgene: ALPPL2 Kegg: 251 H-InvDB: ALPPL2

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ALPPL2 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for ALPPL2 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for ALPPL2 gene:
    Search GeneIP for patents involving ALPPL2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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