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Aliases for ALPPL2 Gene

Aliases for ALPPL2 Gene

  • Alkaline Phosphatase, Placental Like 2 2 3 5
  • Alkaline Phosphatase Nagao Isozyme 3 4
  • Germ Cell Alkaline Phosphatase 3 4
  • EC 4 61
  • ALP-1 3 4
  • ALPPL 3 4
  • GCAP 3 4
  • Testicular And Thymus Alkaline Phosphatase 3
  • Alkaline Phosphatase, Placental-Like 2 2
  • Alkaline Phosphatase, Placental-Like 3
  • Placental-Like Alkaline Phosphatase 3
  • Placental Alkaline Phosphatase-Like 4
  • Nagao Isozyme 3
  • PLAP-Like 4
  • ALPG 3

External Ids for ALPPL2 Gene

Previous GeneCards Identifiers for ALPPL2 Gene

  • GC02P231328
  • GC02P232001
  • GC02P233235
  • GC02P233474
  • GC02P233097
  • GC02P232979
  • GC02P233273
  • GC02P225122

Summaries for ALPPL2 Gene

Entrez Gene Summary for ALPPL2 Gene

  • There are at least four distinct but related alkaline phosphatases: intestinal, placental, placental-like, and liver/bone/kidney (tissue non-specific). The product of this gene is a membrane bound glycosylated enzyme, localized to testis, thymus and certain germ cell tumors, that is closely related to both the placental and intestinal forms of alkaline phosphatase. [provided by RefSeq, Jul 2008]

GeneCards Summary for ALPPL2 Gene

ALPPL2 (Alkaline Phosphatase, Placental Like 2) is a Protein Coding gene. Diseases associated with ALPPL2 include Seminoma and Gonadoblastoma. Among its related pathways are Nicotinate and nicotinamide metabolism and Folate biosynthesis. GO annotations related to this gene include phosphatase activity and alkaline phosphatase activity. An important paralog of this gene is ALPP.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ALPPL2 Gene

Genomics for ALPPL2 Gene

Regulatory Elements for ALPPL2 Gene

Enhancers for ALPPL2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH02F232418 1.2 FANTOM5 Ensembl ENCODE 4.8 +13.1 13126 3.9 ZNF263 ELF3 CTCF MAZ ZNF687 RNF2 NRF1 CBX2 CTBP1 SCRT2 ECEL1P2 ALPPL2 ENSG00000237087 ECEL1P1
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ALPPL2 on UCSC Golden Path with GeneCards custom track

Genomic Location for ALPPL2 Gene

232,406,842 bp from pter
232,410,714 bp from pter
3,873 bases
Plus strand

Genomic View for ALPPL2 Gene

Genes around ALPPL2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ALPPL2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ALPPL2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ALPPL2 Gene

Proteins for ALPPL2 Gene

  • Protein details for ALPPL2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Alkaline phosphatase, placental-like
    Protein Accession:
    Secondary Accessions:
    • A8KAF2
    • Q16727
    • Q53S81
    • Q96CM1

    Protein attributes for ALPPL2 Gene

    532 amino acids
    Molecular mass:
    57377 Da
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
    Quaternary structure:
    • Homodimer.
    • In most mammals there are four different isozymes: placental, placental-like, intestinal and tissue non-specific (liver/bone/kidney).
    • Sequence=CAA30232.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

neXtProt entry for ALPPL2 Gene

Selected DME Specific Peptides for ALPPL2 Gene


Post-translational modifications for ALPPL2 Gene

  • Glycosylation at Asn 141 and Asn 268
  • Modification sites at PhosphoSitePlus

Other Protein References for ALPPL2 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Cloud-Clone Corp. Antibodies for ALPPL2

Domains & Families for ALPPL2 Gene

Gene Families for ALPPL2 Gene

Suggested Antigen Peptide Sequences for ALPPL2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the alkaline phosphatase family.
  • Belongs to the alkaline phosphatase family.
genes like me logo Genes that share domains with ALPPL2: view

Function for ALPPL2 Gene

Molecular function for ALPPL2 Gene

GENATLAS Biochemistry:
phosphatase alkaline,placental-like 2
UniProtKB/Swiss-Prot CatalyticActivity:
A phosphate monoester + H(2)O = an alcohol + phosphate.

Enzyme Numbers (IUBMB) for ALPPL2 Gene

Gene Ontology (GO) - Molecular Function for ALPPL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004035 alkaline phosphatase activity NAS 2162249
GO:0016787 hydrolase activity IEA --
GO:0016791 phosphatase activity IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ALPPL2: view
genes like me logo Genes that share phenotypes with ALPPL2: view

Animal Models for ALPPL2 Gene

MGI Knock Outs for ALPPL2:

Animal Model Products

miRNA for ALPPL2 Gene

miRTarBase miRNAs that target ALPPL2

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ALPPL2 Gene

Localization for ALPPL2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ALPPL2 Gene

Cell membrane; Lipid-anchor, GPI-anchor.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ALPPL2 gene
Compartment Confidence
plasma membrane 5
extracellular 5
peroxisome 1
endoplasmic reticulum 1
lysosome 1

Gene Ontology (GO) - Cellular Components for ALPPL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IEA --
GO:0016020 membrane IEA --
GO:0031225 anchored component of membrane IEA --
genes like me logo Genes that share ontologies with ALPPL2: view

Pathways & Interactions for ALPPL2 Gene

genes like me logo Genes that share pathways with ALPPL2: view

Pathways by source for ALPPL2 Gene

Interacting Proteins for ALPPL2 Gene

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)
Selected Interacting proteins: ENSP00000295453 P10696-PPBN_HUMAN for ALPPL2 Gene via STRING IID

Gene Ontology (GO) - Biological Process for ALPPL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008152 metabolic process IEA --
GO:0016311 dephosphorylation IEA --
genes like me logo Genes that share ontologies with ALPPL2: view

No data available for SIGNOR curated interactions for ALPPL2 Gene

Drugs & Compounds for ALPPL2 Gene

(13) Drugs for ALPPL2 Gene - From: DrugBank, DGIdb, FDA Approved Drugs, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Amifostine Approved, Investigational Pharma Target, inducer 81
Ethyol Approved December 8, 1995 Pharma 0
Isopropyl alcohol Approved Pharma 0
Phosphoric acid Approved Pharma 0
Water Approved Pharma 0

(13) Additional Compounds for ALPPL2 Gene - From: HMDB and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
  • 1-Butanol
  • 1-Butyl alcohol
  • Butanol
  • Butyl alcohol
  • Butyl hydroxide
  • 1-Hexanol
  • 1-Hexyl alcohol
  • 1-Hydroxyhexane
  • Alcohol C-6
  • Alcohol(C6)
  • 1-Pentanol
  • 1-Pentol
  • 1-Pentyl alcohol
  • Alcool amylique
  • Alcool amylique (french)
dihydroneopterin triphosphate
  • 2-Amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl) dihydropteridine triphosphate
  • 6-(L-Erythro-1,2-Dihydroxypropyl 3-triphosphate)-7,8-dihydropterin
  • 6-[(1S,2R)-1,2-Dihydroxy-3-triphosphooxypropyl]-7,8-dihydropterin
  • 7,8-Dihydroneopterin 3'-triphosphate
  • 7,8-Dihydroneopterin triphosphate
Dihydroxyacetone phosphate
  • 1,3-Dihydroxy-2-Propanone mono(dihydrogen phosphate)
  • 1,3-Dihydroxy-2-propanone phosphate
  • 1,3-Dihydroxyacetone 1-phosphate
  • 1-Hydroxy-3-(phosphonooxy)-2-Propanone
  • 1-Hydroxy-3-(phosphonooxy)acetone
genes like me logo Genes that share compounds with ALPPL2: view

Transcripts for ALPPL2 Gene

mRNA/cDNA for ALPPL2 Gene

(1) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(152) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ALPPL2 Gene

Alkaline phosphatase, placental-like 2:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ALPPL2 Gene

No ASD Table

Relevant External Links for ALPPL2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ALPPL2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ALPPL2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ALPPL2 Gene

This gene is overexpressed in Colon - Transverse (x10.4), Lung (x9.7), Testis (x9.6), Fallopian Tube (x7.4), and Cervix - Endocervix (x5.3).

Protein differential expression in normal tissues from HIPED for ALPPL2 Gene

This gene is overexpressed in Fetal ovary (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ALPPL2 Gene

Protein tissue co-expression partners for ALPPL2 Gene

NURSA nuclear receptor signaling pathways regulating expression of ALPPL2 Gene:


SOURCE GeneReport for Unigene cluster for ALPPL2 Gene:


mRNA Expression by UniProt/SwissProt for ALPPL2 Gene:

Tissue specificity: Trace amounts in the testis and thymus, and in elevated amounts in germ cell tumors.
genes like me logo Genes that share expression patterns with ALPPL2: view

Orthologs for ALPPL2 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for ALPPL2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ALPPL2 34 35
  • 99.06 (n)
(Mus musculus)
Mammalia Alppl2 34 16 35
  • 78.19 (n)
Alpi 35
  • 70 (a)
Akp3 35
  • 69 (a)
(Rattus norvegicus)
Mammalia Alpp 34
  • 77.51 (n)
(Bos Taurus)
Mammalia -- 35
  • 77 (a)
-- 35
  • 76 (a)
-- 35
  • 73 (a)
-- 35
  • 73 (a)
(Canis familiaris)
Mammalia -- 35
  • 72 (a)
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 72 (a)
(Monodelphis domestica)
Mammalia -- 35
  • 70 (a)
(Gallus gallus)
Aves -- 35
  • 64 (a)
(Anolis carolinensis)
Reptilia -- 35
  • 60 (a)
(Danio rerio)
Actinopterygii alpi.2 35
  • 55 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG3290 36 34 35
  • 52.65 (n)
Aph-4 36 35
  • 44 (a)
CG5656 36 35
  • 44 (a)
CG10827 36 35
  • 43 (a)
CG1809 36 35
  • 43 (a)
CG10592 36 35
  • 42 (a)
CG3264 36 35
  • 42 (a)
CG5150 36 35
  • 42 (a)
CG3292 36 35
  • 41 (a)
CG8105 36 35
  • 39 (a)
CG16771 36 35
  • 38 (a)
CG8147 35
  • 34 (a)
CG5361 35
  • 22 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes PHO8 35 37
  • 21 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 40 (a)
-- 35
  • 39 (a)
-- 35
  • 38 (a)
CSA.180 35
  • 38 (a)
CSA.4362 35
  • 37 (a)
Species where no ortholog for ALPPL2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ALPPL2 Gene

Gene Tree for ALPPL2 (if available)
Gene Tree for ALPPL2 (if available)

Paralogs for ALPPL2 Gene

Paralogs for ALPPL2 Gene

(3) SIMAP similar genes for ALPPL2 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with ALPPL2: view

Variants for ALPPL2 Gene

Sequence variations from dbSNP and Humsavar for ALPPL2 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs1009934 -- 232,410,170(+) CATAT(C/G)CTGAG downstream-variant-500B, utr-variant-3-prime
rs1048983 --
rs1048986 -- 232,407,939(+) TCGGA(C/T)GCCGA reference, synonymous-codon
rs1048987 -- 232,407,987(+) ATCGC(C/T)ACGCA reference, synonymous-codon
rs1048992 --

Structural Variations from Database of Genomic Variants (DGV) for ALPPL2 Gene

Variant ID Type Subtype PubMed ID
nsv821918 CNV gain 20364138
nsv584693 CNV loss 21841781
nsv584692 CNV loss 21841781
nsv584687 CNV gain+loss 21841781
nsv584679 CNV gain 21841781
nsv522450 CNV loss 19592680
nsv521461 CNV loss 19592680
nsv518263 CNV loss 19592680
nsv482058 CNV gain 20164927
nsv472038 CNV novel sequence insertion 20440878
nsv436293 CNV deletion 17901297
nsv1009043 CNV gain 25217958
nsv1003690 CNV gain+loss 25217958
esv3893572 CNV loss 25118596
esv3893570 CNV gain+loss 25118596
esv3594652 CNV gain 21293372
esv3594651 CNV loss 21293372
esv3594649 CNV gain 21293372
esv3594646 CNV loss 21293372
esv3575340 CNV gain 25503493
esv3575339 CNV gain 25503493
esv3561154 CNV deletion 23714750
esv34493 CNV gain 17911159
esv2763626 CNV gain+loss 21179565
esv2760660 CNV loss 21179565
esv2759118 CNV gain 17122850
esv2659833 CNV deletion 23128226
dgv765e214 CNV loss 21293372
dgv7338n54 CNV gain 21841781
dgv7337n54 CNV loss 21841781
dgv7336n54 CNV gain 21841781
dgv632e201 CNV deletion 23290073
dgv494n27 CNV gain 19166990
dgv493n27 CNV loss 19166990
dgv4187n100 CNV loss 25217958
dgv4186n100 CNV loss 25217958
dgv4185n100 CNV gain 25217958
dgv4184n100 CNV loss 25217958
dgv4183n100 CNV gain+loss 25217958
dgv4182n100 CNV gain 25217958
dgv160n111 CNV duplication 26073780
dgv1218e212 CNV loss 25503493

Variation tolerance for ALPPL2 Gene

Residual Variation Intolerance Score: 91.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.54; 64.83% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ALPPL2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ALPPL2 Gene

Disorders for ALPPL2 Gene

MalaCards: The human disease database

(6) MalaCards diseases for ALPPL2 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
  • seminoma, pure
  • ovarian gonadoblastoma
  • choriocarcinoma, no icd-o subtype
  • cryptorchism
malignant germ cell tumor
  • germ cell cancer
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for ALPPL2

Genetic Association Database (GAD)
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with ALPPL2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ALPPL2 Gene

Publications for ALPPL2 Gene

  1. Molecular cloning of complementary DNAs encoding alkaline phosphatase in human colon cancer cells. (PMID: 2297757) Gum J.R. Jr. … Kim Y.S. (Cancer Res. 1990) 3 4 22 64
  2. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PMID: 15815621) Hillier L.W. … Wilson R.K. (Nature 2005) 3 4 64
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  4. Elevated serum alkaline phosphatase may enable early diagnosis of ovarian cancer. (PMID: 10471145) Ben-Arie A. … Dgani R. (Eur. J. Obstet. Gynecol. Reprod. Biol. 1999) 3 22 64
  5. Characterization of alkaline phosphatase genes expressed in seminoma by cDNA cloning. (PMID: 9823315) Shigenari A. … Inoko H. (Cancer Res. 1998) 3 22 64

Products for ALPPL2 Gene

Sources for ALPPL2 Gene

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