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Aliases for ALPP Gene

Aliases for ALPP Gene

  • Alkaline Phosphatase, Placental 2 3 5
  • Alkaline Phosphatase Regan Isozyme 3 4
  • Placental Alkaline Phosphatase 1 3 4
  • EC 4 63
  • PLAP-1 3 4
  • PLAP 3 4
  • Alkaline Phosphatase, Placental (Regan Isozyme) 2
  • Alkaline Phosphomonoesterase 3
  • Glycerophosphatase 3
  • Regan Isozyme 2
  • PALP 3
  • ALP 3

External Ids for ALPP Gene

Previous GeneCards Identifiers for ALPP Gene

  • GC02P231300
  • GC02P231972
  • GC02P233207
  • GC02P233445
  • GC02P233068
  • GC02P232951
  • GC02P233244
  • GC02P225094

Summaries for ALPP Gene

Entrez Gene Summary for ALPP Gene

  • The protein encoded by this gene is an alkaline phosphatase, a metalloenzyme that catalyzes the hydrolysis of phosphoric acid monoesters. It belongs to a multigene family composed of four alkaline phosphatase isoenzymes. The enzyme functions as a homodimer and has a catalytic site containing one magnesium and two zinc ions, which are required for its enzymatic function. The protein is primarily expressed in placental and endometrial tissue; however, strong ectopic expression has been detected in ovarian adenocarcinoma, serous cystadenocarcinoma, and other ovarian cancer cells. [provided by RefSeq, Jan 2015]

GeneCards Summary for ALPP Gene

ALPP (Alkaline Phosphatase, Placental) is a Protein Coding gene. Diseases associated with ALPP include Obstructive Jaundice and Hepatic Tuberculosis. Among its related pathways are Mesenchymal Stem Cell Differentiation Pathways and Lineage-specific Markers and Embryonic and Induced Pluripotent Stem Cell Differentiation Pathways and Lineage-specific Markers. GO annotations related to this gene include magnesium ion binding and alkaline phosphatase activity. An important paralog of this gene is ALPL.

Gene Wiki entry for ALPP Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ALPP Gene

Genomics for ALPP Gene

Regulatory Elements for ALPP Gene

Enhancers for ALPP Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around ALPP on UCSC Golden Path with GeneCards custom track

Genomic Location for ALPP Gene

232,378,534 bp from pter
232,382,889 bp from pter
4,356 bases
Plus strand

Genomic View for ALPP Gene

Genes around ALPP on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ALPP Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ALPP Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ALPP Gene

Proteins for ALPP Gene

  • Protein details for ALPP Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Alkaline phosphatase, placental type
    Protein Accession:
    Secondary Accessions:
    • P05188
    • P06861
    • Q53S78
    • Q96DB7

    Protein attributes for ALPP Gene

    535 amino acids
    Molecular mass:
    57954 Da
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
    Quaternary structure:
    • Homodimer.
    • In most mammals there are four different isozymes: placental, placental-like, intestinal and tissue non-specific (liver/bone/kidney).
    • Sequence=AAA51708.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for ALPP Gene

neXtProt entry for ALPP Gene

Proteomics data for ALPP Gene at MOPED

Post-translational modifications for ALPP Gene

  • Glycosylation at Asn 144 and Asn 271
  • Modification sites at PhosphoSitePlus

Other Protein References for ALPP Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • R&D Systems Antibodies for ALPP (Alkaline Phosphatase/ALPP)
  • R&D Systems Antibodies for ALPP (Alkaline Phosphatase/ALPP/ALPI)
  • Cell Signaling Technology (CST) Antibodies for ALPP (ALPP)

Domains & Families for ALPP Gene

Gene Families for ALPP Gene

Suggested Antigen Peptide Sequences for ALPP Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the alkaline phosphatase family.
  • Belongs to the alkaline phosphatase family.
genes like me logo Genes that share domains with ALPP: view

Function for ALPP Gene

Molecular function for ALPP Gene

GENATLAS Biochemistry:
phosphatase alkaline,placental (Regan isozyme)
UniProtKB/Swiss-Prot CatalyticActivity:
A phosphate monoester + H(2)O = an alcohol + phosphate.

Enzyme Numbers (IUBMB) for ALPP Gene

Gene Ontology (GO) - Molecular Function for ALPP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003824 catalytic activity IEA --
GO:0016791 phosphatase activity IEA --
genes like me logo Genes that share ontologies with ALPP: view
genes like me logo Genes that share phenotypes with ALPP: view

Animal Model Products

CRISPR Products

No data available for Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for ALPP Gene

Localization for ALPP Gene

Subcellular locations from UniProtKB/Swiss-Prot for ALPP Gene

Cell membrane; Lipid-anchor, GPI-anchor.

Subcellular locations from

Jensen Localization Image for ALPP Gene COMPARTMENTS Subcellular localization image for ALPP gene
Compartment Confidence
plasma membrane 5
cytoskeleton 3
cytosol 3
endoplasmic reticulum 3
extracellular 3
nucleus 3
vacuole 3
endosome 2
golgi apparatus 2
lysosome 2
mitochondrion 2
peroxisome 2

No data available for Gene Ontology (GO) - Cellular Components for ALPP Gene

Pathways & Interactions for ALPP Gene

genes like me logo Genes that share pathways with ALPP: view

Gene Ontology (GO) - Biological Process for ALPP Gene


No data available for SIGNOR curated interactions for ALPP Gene

Drugs & Compounds for ALPP Gene

(72) Drugs for ALPP Gene - From: DrugBank, ApexBio, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
4-Nitrophenol Experimental Pharma 0
Dihydroxyacetone Experimental Pharma 0
4-Nitrophenyl phosphate Experimental Pharma 0
7,8-Dihydroneopterin Experimental Pharma 0

(73) Additional Compounds for ALPP Gene - From: Novoseek and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
dihydroneopterin triphosphate
  • 2-Amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl) dihydropteridine triphosphate
  • 6-(L-Erythro-1,2-Dihydroxypropyl 3-triphosphate)-7,8-dihydropterin
  • 6-[(1S,2R)-1,2-Dihydroxy-3-triphosphooxypropyl]-7,8-dihydropterin
  • 7,8-Dihydroneopterin 3'-triphosphate
  • 7,8-Dihydroneopterin triphosphate
Dihydroxyacetone phosphate
  • 1,3-Dihydroxy-2-Propanone mono(dihydrogen phosphate)
  • 1,3-Dihydroxy-2-propanone phosphate
  • 1,3-Dihydroxyacetone 1-phosphate
  • 1-Hydroxy-3-(phosphonooxy)-2-Propanone
  • 1-Hydroxy-3-(phosphonooxy)acetone
  • NFB Orthophosphate
  • O-Phosphoric acid
  • Ortho-phosphate
  • Orthophosphate (PO43-)
  • Orthophosphate(3-)
phosphoric acid
  • Acide phosphorique (FRENCH)
  • Acido fosforico [Italian]
  • Acidum phosphoricum
  • Diphosphate tetrasodium
  • Fosforzuuroplossingen [Dutch]
  • Dihydrogen oxide
  • Steam

(1) ApexBio Compounds for ALPP Gene

Compound Action Cas Number
(-)-p-Bromotetramisole Oxalate 62284-79-1
genes like me logo Genes that share compounds with ALPP: view

Transcripts for ALPP Gene

mRNA/cDNA for ALPP Gene

Unigene Clusters for ALPP Gene

Alkaline phosphatase, placental:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ALPP Gene

No ASD Table

Relevant External Links for ALPP Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ALPP Gene

mRNA expression in normal human tissues for ALPP Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ALPP Gene

This gene is overexpressed in Lung (x33.1), Cervix - Endocervix (x9.2), and Fallopian Tube (x4.9).

Protein differential expression in normal tissues from HIPED for ALPP Gene

This gene is overexpressed in Cervix (35.1) and Placenta (32.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for ALPP Gene

SOURCE GeneReport for Unigene cluster for ALPP Gene Hs.284255

mRNA Expression by UniProt/SwissProt for ALPP Gene

Tissue specificity: Detected in placenta (at protein level).
genes like me logo Genes that share expression patterns with ALPP: view

Protein tissue co-expression partners for ALPP Gene

Primer Products

Orthologs for ALPP Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for ALPP Gene

Organism Taxonomy Gene Similarity Type Details
(Mus musculus)
Mammalia Alpi 35
  • 78.41 (n)
  • 76.58 (a)
Alpi 16
Akp3 36
  • 69 (a)
Alpi 36
  • 69 (a)
Alppl2 36
  • 73 (a)
(Pan troglodytes)
Mammalia ALPP 35
  • 97.99 (n)
  • 98.05 (a)
  • 95 (a)
(Rattus norvegicus)
Mammalia Alpi 35
  • 78.75 (n)
  • 76.46 (a)
(Bos Taurus)
Mammalia -- 36
  • 75 (a)
-- 36
  • 76 (a)
-- 36
  • 74 (a)
-- 36
  • 74 (a)
(Canis familiaris)
Mammalia -- 36
  • 73 (a)
(Monodelphis domestica)
Mammalia -- 36
  • 70 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 73 (a)
(Gallus gallus)
Aves -- 36
  • 64 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 60 (a)
(Danio rerio)
Actinopterygii alp3 36
  • 51 (a)
fruit fly
(Drosophila melanogaster)
Insecta Aph-4 37
  • 43 (a)
CG10592 37
  • 43 (a)
CG10827 37
  • 42 (a)
CG16771 37
  • 38 (a)
CG1809 37
  • 43 (a)
CG3264 37
  • 42 (a)
CG3290 37
  • 42 (a)
CG3292 37
  • 40 (a)
CG5150 37
  • 42 (a)
CG5656 37
  • 44 (a)
CG8105 37
  • 38 (a)
Aph-4 35
  • 53.41 (n)
  • 46.74 (a)
Aph-4 36
  • 33 (a)
CG10592 36
  • 34 (a)
CG10827 36
  • 35 (a)
CG16771 36
  • 27 (a)
CG1809 36
  • 37 (a)
CG3264 36
  • 34 (a)
CG3290 36
  • 32 (a)
CG3292 36
  • 32 (a)
CG5150 36
  • 35 (a)
CG5361 36
  • 22 (a)
CG5656 36
  • 37 (a)
CG8105 36
  • 35 (a)
CG8147 36
  • 34 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP010596 35
  • 52.05 (n)
  • 43.86 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes PHO8 36
  • 21 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 39 (a)
-- 36
  • 38 (a)
-- 36
  • 39 (a)
CSA.180 36
  • 38 (a)
CSA.4362 36
  • 37 (a)
Species with no ortholog for ALPP:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ALPP Gene

Gene Tree for ALPP (if available)
Gene Tree for ALPP (if available)

Paralogs for ALPP Gene

Paralogs for ALPP Gene

(3) SIMAP similar genes for ALPP Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with ALPP: view

Variants for ALPP Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for ALPP Gene

Placental ALP is highly polymorphic, there are at least three common alleles.

Sequence variations from dbSNP and Humsavar for ALPP Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs1130335 - 232,378,876(+) CATCC(C/T)AGGTA reference, missense
rs13026692 - 232,379,271(+) CTGAG(A/T)TACCC reference, missense
rs1048988 - 232,380,220(+) GTTTC(C/G/T)CATGG reference, missense
rs2853378 - 232,380,316(+) GAAGC(A/G)CCAGG reference, missense
rs1048994 - 232,381,539(+) GGACG(A/G)AGAGA reference, missense

Structural Variations from Database of Genomic Variants (DGV) for ALPP Gene

Variant ID Type Subtype PubMed ID
nsv875971 CNV Loss 21882294
nsv522450 CNV Loss 19592680
esv34493 CNV Gain 17911159
nsv821918 CNV Gain 20364138
nsv875977 CNV Loss 21882294
dgv675e201 CNV Deletion 23290073
dgv4449n71 CNV Gain 21882294
nsv875979 CNV Gain 21882294
esv2659833 CNV Deletion 23128226
dgv493n27 CNV Loss 19166990
dgv4450n71 CNV Loss 21882294
dgv4451n71 CNV Gain+Loss 21882294
dgv494n27 CNV Gain 19166990
nsv436293 CNV Deletion 17901297
dgv1294e1 CNV Complex 17122850
nsv521461 CNV Loss 19592680
nsv438382 CNV Loss 16468122
nsv875992 CNV Gain 21882294
nsv875994 CNV Gain 21882294
dgv4452n71 CNV Gain 21882294
nsv518263 CNV Loss 19592680
nsv875996 CNV Loss 21882294
nsv482057 CNV Gain 20164927

Variation tolerance for ALPP Gene

Residual Variation Intolerance Score: 94.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.14; 84.67% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ALPP Gene

Human Gene Mutation Database (HGMD)

Disorders for ALPP Gene

MalaCards: The human disease database

(151) MalaCards diseases for ALPP Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
obstructive jaundice
  • cholestatic jaundice
hepatic tuberculosis
  • tuberculosis of liver
  • fasciola hepatica infection
  • pineal germinoma
  • childhood hypophosphatasia
- elite association - COSMIC cancer census association via MalaCards
Search ALPP in MalaCards View complete list of genes associated with diseases

Relevant External Links for ALPP

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with ALPP: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ALPP Gene

Publications for ALPP Gene

  1. Products of two common alleles at the locus for human placental alkaline phosphatase differ by seven amino acids. (PMID: 3461452) Henthorn P.S. … Harris H. (Proc. Natl. Acad. Sci. U.S.A. 1986) 2 3 4 67
  2. Membrane features and activity of GPI-anchored enzymes: alkaline phosphatase reconstituted in model membranes. (PMID: 18416535) Sesana S. … Masserini M. (Biochemistry 2008) 3 23
  3. Biochemical response to ursodeoxycholic acid and long-term prognosis in primary biliary cirrhosis. (PMID: 18752324) Corpechot C. … Poupon R. (Hepatology 2008) 3 23
  4. Structural studies of human alkaline phosphatase in complex with strontium: implication for its secondary effect in bones. (PMID: 16815919) Llinas P. … Le Du M.H. (Protein Sci. 2006) 3 23
  5. Enzyme polymorphisms, smoking, and human reproduction. A study of human placental alkaline phosphatase. (PMID: 14595869) Magrini A. … Bottini E. (Am. J. Hum. Biol. 2003) 3 23

Products for ALPP Gene

Sources for ALPP Gene