Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ALPP Gene

protein-coding   GIFtS: 68
GCID: GC02P233244

Alkaline Phosphatase, Placental

(Previous names: alkaline phosphatase, placental (Regan isozyme))
Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Alkaline Phosphatase, Placental1 2     Alkaline Phosphatase, Placental (Regan Isozyme)1
Regan Isozyme1 2     ALP2
Alkaline Phosphatase Regan Isozyme2 3     PALP2
Placental Alkaline Phosphatase 12 3     Alkaline Phosphatase, Placental Type2
PLAP2 3     Alkaline Phosphomonoesterase2
PLAP-12 3     glycerophosphatase2
EC 3.1.3.13 8     

External Ids:    HGNC: 4391   Entrez Gene: 2502   Ensembl: ENSG000001632837   OMIM: 1718005   UniProtKB: P051873   

Export aliases for ALPP gene to outside databases

Previous GC identifers: GC02P231300 GC02P231972 GC02P233207 GC02P233445 GC02P233068 GC02P232951 GC02P225094


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for ALPP Gene:
There are at least four distinct but related alkaline phosphatases: intestinal, placental, placental-like, and
liver/bone/kidney (tissue non-specific). The first three are located together on chromosome 2 while the tissue
non-specific form is located on chromosome 1. The product of this gene is a membrane bound glycosylated enzyme,
also referred to as the heat stable form, that is expressed primarily in the placenta although it is closely
related to the intestinal form of the enzyme as well as to the placental-like form. The coding sequence for this
form of alkaline phosphatase is unique in that the 3' untranslated region contains multiple copies of an Alu
family repeat. In addition, this gene is polymorphic and three common alleles (type 1, type 2 and type 3) for
this form of alkaline phosphatase have been well characterized. (provided by RefSeq, Jul 2008)

GeneCards Summary for ALPP Gene: 
ALPP (alkaline phosphatase, placental) is a protein-coding gene. Diseases associated with ALPP include waardenburg syndrome type i, and hypophosphatasia, infantile, and among its related super-pathways are Nicotinate and nicotinamide metabolism and Metabolism. GO annotations related to this gene include alkaline phosphatase activity and metal ion binding. An important paralog of this gene is ALPPL2.

Gene Wiki entry for ALPP (Placental alkaline phosphatase) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000002.11  NT_005403.17  NC_018913.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ALPP gene promoter:
         AML1a   GCNF   CUTL1   NF-kappaB   SRY   POU2F1   POU2F1a   NF-kappaB2   TGIF   NF-kappaB1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidALPP promoter sequence
   Search SABiosciences Chromatin IP Primers for ALPP

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ALPP


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q37   Ensembl cytogenetic band:  2q37.1   HGNC cytogenetic band: 2q37.1

ALPP Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ALPP gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02P233244:  view genomic region     (about GC identifiers)

Start:
233,243,244 bp from pter      End:
233,247,599 bp from pter
Size:
4,356 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: PPB1_HUMAN, P05187 (See protein sequence)
Recommended Name: Alkaline phosphatase, placental type precursor  
Size: 535 amino acids; 57954 Da
Cofactor: Binds 1 magnesium ion (By similarity)
Cofactor: Binds 2 zinc ions (By similarity)
Subunit: Homodimer
Subcellular location: Cell membrane; Lipid-anchor, GPI-anchor
Miscellaneous: In most mammals there are four different isozymes: placental, placental-like, intestinal and tissue
non-specific (liver/bone/kidney)
Sequence caution: Sequence=AAA51708.1; Type=Erroneous initiation;
6/8 PDB 3D structures from and Proteopedia for ALPP (see all 8):
1EW2 (3D)        1ZEB (3D)        1ZED (3D)        1ZEF (3D)        2GLQ (3D)        3MK0 (3D)    
Secondary accessions: P05188 P06861 Q53S78 Q96DB7

Explore the universe of human proteins at neXtProt for ALPP: NX_P05187

Explore proteomics data for ALPP at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P05187

  • 4/17 DME Specific Peptides for ALPP (P05187) (see all 17)
     TTRGNEV  VEGGRID  NLVQEWL  GVVTTTR 

    ALPP Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    ALPP Protein Expression
    REFSEQ proteins: NP_001623.3  
    ENSEMBL proteins: 
     ENSP00000375881  

    Human Recombinant Protein Products for ALPP: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for ALPP
    OriGene Protein Over-expression Lysate for ALPP
    OriGene MassSpec for ALPP 
    OriGene Custom Protein Services for ALPP
    GenScript Custom Purified and Recombinant Proteins Services for ALPP
    Novus Biologicals ALPP Protein
    Novus Biologicals ALPP Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    ProSpec Recombinant Protein for ALPP
    Cloud-Clone Corp. Proteins for ALPP 

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane IEA--
    GO:0009986cell surface IDA12493773
    GO:0016021integral to membrane IEA--
    GO:0031225anchored to membrane IEA--

    ALPP for ontologies           About GeneDecksing



    ALPP Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of ALPP
    R&D Systems Antibodies for ALPP (Alkaline Phosphatase/ALPP/ALPI, Alkaline Phosphatase/ALPP)
    Cell Signaling Technology (CST) Antibodies for ALPP 
    OriGene Antibodies for ALPP
    OriGene Custom Antibody Services for ALPP
    GenScript Custom Superior Antibodies Services for ALPP
    Novus Biologicals ALPP Antibodies
    Abcam antibodies for ALPP
    Cloud-Clone Corp. Antibodies for ALPP 
    ThermoFisher Antibody for ALPP
    LSBio Antibodies in human, mouse, rat for ALPP 

    Assay Products for ALPP: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for ALPP
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for ALPP
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for ALPP 
    Cloud-Clone Corp. CLIAs for ALPP


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    4 InterPro protein domains:
     IPR001952 Alkaline_phosphatase
     IPR017849 Alkaline_Pase-like_a/b/a
     IPR017850 Alkaline_phosphatase_core
     IPR018299 Alkaline_phosphatase_AS

    Graphical View of Domain Structure for InterPro Entry P05187

    ProtoNet protein and cluster: P05187

    1 Blocks protein domain: IPB001952 Alkaline phosphatase

    UniProtKB/Swiss-Prot: PPB1_HUMAN, P05187
    Similarity: Belongs to the alkaline phosphatase family


    ALPP for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: PPB1_HUMAN, P05187
    Catalytic activity: A phosphate monoester + H(2)O = an alcohol + phosphate

         Genatlas biochemistry entry for ALPP:
    phosphatase alkaline,placental (Regan isozyme)

         Enzyme Number (IUBMB): EC 3.1.3.11 2

         Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003824catalytic activity ----
    GO:0004035alkaline phosphatase activity NAS3042787
    GO:0016791phosphatase activity ----
    GO:0046872metal ion binding IEA--
         
    ALPP for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for ALPP:
     Decreased focal adhesion (FA)   Decreased nuclei size in G2M 

         5 MGI mutant phenotypes (inferred from 1 allele(MGI details for Alppl2):
     embryogenesis  growth/size  mortality/aging  normal  reproductive system 

    ALPP for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Alppl2tm1Jlm for ALPP

       inGenious Targeting Laboratory - Custom generated mouse model solutions for ALPP 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for ALPP

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for ALPP 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for ALPP 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ALPP
    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate ALPP
    SwitchGear 3'UTR luciferase reporter plasmidALPP 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for ALPP
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ALPP

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for ALPP
    Sirion Biotech Customized adenovirus for overexpression of ALPP

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for ALPP (see all 7)
    OriGene ORF clones in mouse, rat for ALPP
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: ALPP (NM_001632)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ALPP
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ALPP
    Sirion Biotech Customized lentivirus for stable overexpression of ALPP 
                         Customized lentivirus expression plasmids for stable overexpression of ALPP 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for ALPP
    Search LifeMap BioReagents cell lines for ALPP
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ALPP


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for ALPP About                                                                                                See pathways by source

    SuperPathContained pathways About
    1NAD metabolism
    NAD metabolism0.43
    2Metabolism
    Metabolic pathways0.40
    3Purine metabolism
    ATP/ITP metabolism0.31
    4Phosphatases
    Phosphatases
    5Folate biosynthesis
    Folate biosynthesis

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    2 EMD Millipore Pathways for ALPP
        NAD metabolism
    ATP/ITP metabolism


    1 Cell Signaling Technology (CST) Pathway for ALPP
        Phosphatases

    2 GeneGo (Thomson Reuters) Pathways for ALPP
        NAD metabolism
    ATP/ITP metabolism


    2         Kegg Pathways  (Kegg details for ALPP):
        Folate biosynthesis
    Metabolic pathways


    ALPP for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for ALPP

    STRING Interaction Network Preview (showing 5 interactants - click image to see 17)

    5/51 Interacting proteins for ALPP (P051872, 3 ENSP000003758814) via UniProtKB, MINT, STRING, and/or I2D (see all 51)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PIGKQ926432, 3, ENSP000003598484MINT-8216721 I2D: score=3 STRING: ENSP00000359848
    GPAA1O432922, 3, ENSP000003472064MINT-8216714 I2D: score=1 STRING: ENSP00000347206
    ASPSCR1Q9BZE93, ENSP000003021764I2D: score=1 STRING: ENSP00000302176
    FAF1Q9UNN53, ENSP000003794574I2D: score=1 STRING: ENSP00000379457
    NSFL1CQ9UNZ23, ENSP000002168794I2D: score=1 STRING: ENSP00000216879
    About this table

    Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008152metabolic process ----

    ALPP for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    ALPP for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ALPP (PPB1)

    8 HMDB Compounds for ALPP    About this table
    CompoundSynonyms CAS #PubMed Ids
    4-Nitrophenol1-Hydroxy-4-nitrobenzene (see all 8)100-02-7--
    7,8-Dihydroneopterin2-Amino-4-hydroxy-6-(D-erythro-1',2',3'-trihydroxypropyl)-7,8-dihydropteridine (see all 11)1218-98-0--
    Dihydroneopterin triphosphate2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl) dihydropteridine triphosphate (see all 5)20574-65-6--
    Dihydroxyacetone1,3-Dihydroxy-2-propanone (see all 21)96-26-4--
    Dihydroxyacetone phosphate1,3-Dihydroxy-2-propanone phosphate (see all 17)57-04-5--
    MagnesiumMagnesium (see all 2)7439-95-4--
    PhosphateNFB Orthophosphate (see all 13)14265-44-2--
    WaterDihydrogen oxide (see all 2)7732-18-5--

    1 DrugBank Compound for ALPP    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    METHYL-PHOSPHONIC ACID MONO-(4-NITRO-PHENYL) ESTER-- --target--10592235

    10/136 Novoseek inferred chemical compound relationships for ALPP gene (see all 136)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    alizarin 80.9 38 16546826 (2), 16845965 (2), 18228270 (2), 16530029 (1) (see all 28)
    p-nitrophenyl phosphate 73.7 33 15895474 (2), 11816056 (1), 8222223 (1), 8034777 (1) (see all 22)
    2-amino-2-methyl-1-propanol 73.4 7 11256805 (1), 17961309 (1), 15719705 (1), 11922923 (1) (see all 6)
    akermanite 71.4 4 16904740 (1), 19545889 (1)
    aspartate 70.6 149 2396080 (1), 9817078 (1), 11236810 (1), 15625352 (1) (see all 99)
    deoxypyridinoline 69.9 72 15050907 (4), 8911707 (3), 14727010 (2), 15166484 (2) (see all 34)
    hydroxyapatite 69.3 81 12740096 (3), 19376000 (3), 18270806 (2), 19012271 (2) (see all 40)
    alanine 68.2 144 2396080 (1), 8425894 (1), 9793665 (1), 9817078 (1) (see all 99)
    pyridinoline 64.1 36 19460508 (2), 10541322 (1), 15860920 (1), 9738702 (1) (see all 17)
    amppd 63.6 7 18402780 (1), 18452138 (1), 16643808 (1), 17719901 (1)

    Search CenterWatch for drugs/clinical trials and news about ALPP / PPB1

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for ALPP gene: 
    NM_001632.3  

    Unigene Cluster for ALPP:

    Alkaline phosphatase, placental
    Hs.284255  [show with all ESTs]
    Unigene Representative Sequence: NM_001632
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000392027(uc002vsq.3) ENST00000474529 ENST00000485563
    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ALPP
    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate ALPP
    SwitchGear 3'UTR luciferase reporter plasmidALPP 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for ALPP
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ALPP
    Clone
    Products:
         
    OriGene clones in human, mouse for ALPP (see all 7)
    OriGene ORF clones in mouse, rat for ALPP
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: ALPP (NM_001632)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ALPP
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ALPP
    Sirion Biotech Customized lentivirus for stable overexpression of ALPP 
                         Customized lentivirus expression plasmids for stable overexpression of ALPP 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for ALPP
    OriGene qSTAR qPCR primer pairs in human, mouse for ALPP
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat ALPP
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ALPP
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ALPP

    Additional mRNA sequence: 

    AF217992.1 AK075432.1 BC009647.1 BC068501.1 BC094743.1 M12551.1 M14169.1 M14170.1 

    7 DOTS entries:

    DT.100687963  DT.100748673  DT.87016630  DT.95156278  DT.95156286  DT.121006034  DT.95156280 

    24/152 AceView cDNA sequences (see all 152):

    AF217992 BC068501 AL554586 BM744140 M14169 CR599162 AL553521 BX095665 
    BM742176 AL553983 R31098 CR621490 BM742455 BX439339 J04948 BX458398 
    BC014139 BE549393 R71624 AL540746 NM_001632 CB995228 BC009647 R62517 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ALPP expression in normal human tissues (normalized intensities)      ALPP embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CCAATTTCAG
    ALPP Expression
    About this image


    ALPP expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/4 selected tissues (see all 4) fully expand
     
     Placenta (Extraembryonic Tissues)
             Placenta-derived mesenchymal stem cells
     
     Inner Cell Mass (Early Embryonic Tissues)
             201B6
     
     Mesenchymal Stem Cells (Muscoskeletal System)
             Placenta-derived mesenchymal stem cells
     
     Eye (Sensory Organs)
             Limbal stem cells

    See ALPP Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ALPP

    SOURCE GeneReport for Unigene cluster: Hs.284255
        SABiosciences Custom PCR Arrays for ALPP
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for ALPP
    OriGene qSTAR qPCR primer pairs in human, mouse for ALPP
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat ALPP
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ALPP
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ALPP
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ALPP

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals and fungi.

    Orthologs for ALPP gene from 6/14 species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Alppl21 , 5 alkaline phosphatase, placental-like 21, 5 77.44(n)1
    75.24(a)1
      1 (44.05 cM)5
    116501  NM_007433.31  NP_031459.31 
     870866905 
    chicken
    (Gallus gallus)
    Aves LOC1008598761 intestinal-type alkaline phosphatase-like 68.75(n)
    66.02(a)
      100859876  XM_003641761.1  XP_003641809.1 
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    (see all 3)
    Alkaline phosphatase
    (see all 3)
    64(a)
    60(a)
    (see all 3)
    possible ortholog
    1 ↔ many
    (see all 3)
    AAWZ02040724(38-6154)
    GL343304.1(677973-694404)
    zebrafish
    (Danio rerio)
    Actinopterygii alpi.26
    alpi.16
    (see all 3)
    alkaline phosphatase, intestinal.1
    (see all 3)
    55(a)
    52(a)
    (see all 3)
    1 ↔ many
    possible ortholog
    (see all 3)
    22(41823911-41838077)
    22(41808075-41823295)
    fruit fly
    (Drosophila melanogaster)
    Insecta CG56563
    CG81471
    alkaline phosphatase3
    CG81471
    44(a)
    (best of 11)3
    54.15(n)1
    45.06(a)1
      78D23
    411351  NM_141640.41  NP_649897.41 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes PHO86
    Repressible vacuolar alkaline phosphatase; regulat...
    18(a)
    1 → many
    IV(1418550-1420250)


    ENSEMBL Gene Tree for ALPP (if available)
    TreeFam Gene Tree for ALPP (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ALPP gene
    ALPPL22  ALPL2  ALPI2  
    3 SIMAP similar genes for ALPP using alignment to 1 protein entry:     PPB1_HUMAN:
    ALPPL2    ALPI    ALPL

    ALPP for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    UniProtKB/Swiss-Prot: PPB1_HUMAN, P05187
    Polymorphism: Placental ALP is highly polymorphic, there are at least three common alleles


    10/386 SNPs in ALPP are shown (see all 386)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs174127701,2
    --225095385(-) TGCGTA/GGCGAT 3 A syn10--------
    rs2015816951,2
    --232614173(+) TTGTA-/TTTTTT 1 -- us2k10--------
    rs1817259901,2
    C--232614215(+) GGCTGC/GTCTTG 1 -- us2k10--------
    rs730019731,2
    C,F--232614285(+) AATTCG/ACCCCC 1 -- us2k13Minor allele frequency- A:0.10WA NA EA 358
    rs781104611,2
    C,F--232614311(+) AACCAC/TGGATG 1 -- us2k11Minor allele frequency- T:0.06WA 118
    rs1434720791,2
    --232614312(+) ACCACG/TGATGA 1 -- us2k10--------
    rs1467705971,2
    C--232614333(+) CCTGCC/TTCCTG 1 -- us2k10--------
    rs1846874531,2
    --232614441(+) CCAAAC/TGACAA 1 -- us2k10--------
    rs74256151,2
    C,F--232614582(+) aaaaaA/Tttagc 1 -- us2k11Minor allele frequency- T:0.03WA 118
    rs1391215571,2
    --232614609(+) TGCCAA/GTAAGC 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for ALPP (233243244 - 233247599 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10/23 variations for ALPP (see all 23):    About this table     
    Variant IDTypeSubtypePubMed ID
    dgv675e201CNV Deletion23290073
    esv2659833CNV Deletion23128226
    nsv436293CNV Deletion17901297
    nsv521461CNV Loss19592680
    dgv4450n71CNV Loss21882294
    nsv875971CNV Loss21882294
    nsv875996CNV Loss21882294
    nsv875977CNV Loss21882294
    nsv522450CNV Loss19592680
    nsv438382CNV Loss16468122

    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing ALPP
    DNA2.0 Custom Variant and Variant Library Synthesis for ALPP

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 171800    OMIM disorders: --

    20/212 diseases for ALPP (see all 212):    About MalaCards
    waardenburg syndrome type i    hypophosphatasia, infantile    dysgerminoma of ovary    aagenaes syndrome
    malignant sertoli cell tumor    central nervous system germinoma    clear cell adenoma    hepatic tuberculosis
    enterocele    clear cell chondrosarcoma    endodermal sinus tumor    mature teratoma
    urethral intrinsic sphincter deficiency    epithelioid trophoblastic tumor    mixed germ cell tumor    gonadoblastoma
    lymphocytic hypophysitis    seminoma    placental site trophoblastic tumor    fascioliasis

    20/54 diseases from the University of Copenhagen DISEASES database for ALPP (see all 54):
    Osteoporosis     Liver disease     Cholestasis     Hyperparathyroidism
    Osteomalacia     Hypophosphatasia     Cholangitis     Rickets
    Paget's disease of bone     Renal osteodystrophy     Hypercalcemia     Kidney failure
    Osteitis fibrosa     Hypersensitivity reaction type II disease     Seminoma     Choledocholithiasis
    Hypophosphatemia     Carcinoma     Breast cancer     Diarrhea

    ALPP for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    The International Symposium on Pneumococci and Pneumococcal Diseases (ISPPD) 9 - 13 March 2014

    10/92 Novoseek inferred disease relationships for ALPP gene (see all 92)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    hypophosphatasia 84.3 29 10451522 (2), 9536930 (2), 2079838 (1), 8675582 (1) (see all 22)
    seminoma 78.7 115 2273701 (5), 8653285 (4), 1646453 (3), 17629966 (3) (see all 43)
    alkaline phosphatase, elevated serum 78.5 17 19212310 (1), 7723166 (1), 7780263 (1), 11142449 (1) (see all 16)
    germinoma 69.9 24 19106497 (2), 1723169 (2), 1966857 (1), 8615089 (1) (see all 14)
    hypophosphatasia, infantile 65 1 19631305 (1)
    osteosarcoma 63.6 42 1651438 (2), 1702922 (2), 9914326 (2), 1611300 (1) (see all 29)
    yolk sac tumor 63.3 4 10469400 (1), 1690172 (1), 8757478 (1)
    calcification 61.6 89 16958693 (3), 15974530 (3), 11401534 (3), 18160010 (2) (see all 61)
    biliary cirrhosis primary 61 6 1934501 (1), 1541936 (1), 18084701 (1), 10535881 (1) (see all 6)
    bone diseases 57.7 17 1458597 (1), 1940065 (1), 9283233 (1), 7923809 (1) (see all 14)

    Genetic Association Database (GAD): ALPP
    Human Genome Epidemiology (HuGE) Navigator: ALPP (1 document)

    Export disorders for ALPP gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ALPP gene, integrated from 9 sources (see all 1608):
    (articles sorted by number of sources associating them with ALPP)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Products of two common alleles at the locus for human placental alkaline phosphatase differ by seven amino acids. (PubMed id 3461452)1, 2, 3 Henthorn P.S.... Harris H. (1986)
    2. Cloning, sequencing, and chromosomal localization of human term placental alkaline phosphatase cDNA. (PubMed id 3001717)1, 2, 3 Kam W.... Rutter W.J. (1985)
    3. Enzyme polymorphisms, smoking, and human reproduction. A study of human placental alkaline phosphatase. (PubMed id 14595869)1, 4, 9 Magrini A....Bottini E. (2003)
    4. Crystal structure of alkaline phosphatase from human placenta at 1.8 A resolution. Implication for a substrate specificity. (PubMed id 11124260)1, 2, 9 Le Du M.H.... Stura E.A. (2001)
    5. A genome-wide association study of northwestern Europ eans involves the C-type natriuretic peptide signaling pathway in the etiology of human height variation. (PubMed id 19570815)1, 4 Estrada K....Kayser M. (2009)
    6. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)1, 2 Hillier L.W....Wilson R.K. (2005)
    7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    8. Function assignment to conserved residues in mammalian alkaline phosphatases. (PubMed id 11937510)1, 2 Kozlenkov A.... Millan J.L. (2002)
    9. Site-specific mutations in the COOH-terminus of placental alkaline phosphatase: a single amino acid change converts a phosphatidylinositol-glycan-anchored protein to a secreted protein. (PubMed id 1730777)1, 2 Lowe M.E. (1992)
    10. Selectivity of the cleavage/attachment site of phosphatidylinositol- glycan-anchored membrane proteins determined by site-specific mutagenesis at Asp-484 of placental alkaline phosphatase. (PubMed id 2153284)1, 2 Micanovic R.... Udenfriend S. (1990)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 250 HGNC: 439 AceView: ALPPandALPPL2 Ensembl:ENSG00000163283 euGenes: HUgn250
    ECgene: ALPP Kegg: 250 H-InvDB: ALPP

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ALPP Pharmacogenomics, SNPs, Pathways
    Wikipedia http://en.wikipedia.org/wiki/Alkaline_phosphatase

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for ALPP gene:
    Search GeneIP for patents involving ALPP

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
     Browse Kits and Assays available from EMD Millipore
     Browse for Gene Knock-down Tools from EMD Millipore
     Browse Small Molecules at EMD Millipore
     Browse Purified and Recombinant Proteins at EMD Millipore
     EMD Millipore Mono- and Polyclonal Antibodies for the study of ALPP
     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Antibodies for ALPP (Alkaline Phosphatase/ALPP/ALPI)   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Protease Activity Assays and Reagents   Browse Recombinant/Natural Proteins  
     Browse Stem Cell Products   Browse Tocris Biochemicals & Compounds  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for ALPP   OriGene RNAi products in human, mouse, rat for ALPP  
     OriGene qPCR primer pairs and template standards for ALPP   OriGene Protein Over-expression Lysate for ALPP  
     OriGene MassSpec something-or-other for ALPP   OriGene clones in human, mouse for ALPP  
     OriGene qSTAR qPCR primer pairs in human, mouse for ALPP   OriGene Purified Protein for ALPP  
     OriGene ORF clones in mouse, rat for ALPP   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for ALPP   OriGene Custom Protein Services for ALPP  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat ALPP
     QIAGEN SeqTarget long-range PCR primers for resequencing ALPP
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ALPP
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ALPP
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ALPP
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ALPP
     GenScript Custom Purified and Recombinant Proteins Services for ALPP GenScript cDNA clones with any tag delivered in your preferred vector for ALPP
     GenScript Custom Assay Services for ALPP GenScript Custom Superior Antibodies Services for ALPP
     GenScript Custom overexpressing Cell Line Services for ALPP CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Antibodies & Assays for ALPP 

     Regulatory tfbs in ALPP promoter
     Search Chromatin IP Primers for ALPP
     RT2 qPCR Primer Assay in human, mouse, rat ALPP
     GNC Network for ALPP
     SABiosciences Custom PCR Arrays for ALPP
     Search Tocris compounds for ALPP (PPB1)
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     ALPP antibodies
     ALPP proteins
     ALPP lysates
     Antibodies for ALPP
     See all of Abcam's Antibodies, Kits and Proteins for ALPP
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Recombinant Protein for ALPP




     Proteins for ALPP
     Antibodies for ALPP
     ELISAs for ALPP
     CLIAs for ALPP
     Search LifeMap BioReagents cell lines for ALPP
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ALPP
     SwitchGear 3'UTR luciferase reporter plasmids for ALPP
     SwitchGear Promoter luciferase reporter plasmids for ALPP
     ThermoFisher Antibody for ALPP
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ALPP
     inGenious Targeting Laboratory - Custom generated mouse model solutions for ALPP
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for ALPP
    Customized:
     lentivirus for stable overexpression of ALPP
     lentivirus expression plasmids for stable overexpression of ALPP
     adenovirus for overexpression of ALPP
     LSBio Antibodies in human, mouse, rat for ALPP
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

    View Random Gene

    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      ALPP gene at Home site.
    hostname: 356980-web2.xennexinc.com index build: 106 solr: 1.4