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ALPP Gene

protein-coding GIFtS: 59

GC02P232951

alkaline phosphatase, placental (Regan isozyme)
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
ALP ^²
EC 3.1.3.1 ^³
FLJ61142 ^²
PALP ^²
PLAP ^², ³
PLAP-1 ^³
glycerophosphatase ^²

Descriptions
Alkaline phosphatase Regan isozyme ^³
alkaline phosphatase, placental (Regan isozyme) ^²
alkaline phosphomonoesterase ^²
placental alkaline phosphatase ^²

External Ids
HGNC: 439¹
Entrez Gene: 250²
UniProtKB: P05187³
Ensembl: ENSG00000163283⁷

Search outside databases for aliases for ALPP gene

Previous GC identifers: GC02P231300 GC02P231972 GC02P233207 GC02P233445 GC02P233068

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for ALPP:

There are at least four distinct but related alkaline phosphatases: intestinal, placental,

placental-like, and liver/bone/kidney (tissue non-specific). The first three are located together

on chromosome 2 while the tissue non-specific form is located on chromosome 1. The product of this

gene is a membrane bound glycosylated enzyme, also referred to as the heat stable form, that is

expressed primarily in the placenta although it is closely related to the intestinal form of the

enzyme as well as to the placental-like form. The coding sequence for this form of alkaline

phosphatase is unique in that the 3' untranslated region contains multiple copies of an Alu

family repeat. In addition, this gene is polymorphic and three common alleles (type 1, type 2 and

type 3) for this form of alkaline phosphatase have been well characterized. [provided by RefSeq]

Gene Wiki entry for ALPP

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the ALPP gene

Entrez Gene cytogenetic band: 2q37 Ensembl cytogenetic band: 2q37.1 HGNC cytogenetic band: 2q37.1

ALPP Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 2 GeneLoc Exon Structure

GeneLoc location for GC02P232951: (about GC identifiers)

Start:	232,951,592 bp from pter
End:	232,955,843 bp from pter
Size:	4,252 bases
Orientation:	plus strand

RefSeq DNA sequence:

NC_000002.10 NT_005403.16

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: PPB1_HUMAN, P05187 (See protein sequence)

Recommended Name: Alkaline phosphatase, placental type precursor

Size: 535 amino acids; 57954 Da

Cofactor: Binds 1 magnesium ion (By similarity)

Cofactor: Binds 2 zinc ions (By similarity)

Subunit: Homodimer

Subcellular location: Cell membrane; Lipid-anchor, GPI-anchor

Miscellaneous: In most mammals there are four different isozymes: placental, placental-like,

intestinal and tissue non-specific (liver/bone/kidney)

PDB structures from and Proteopedia :

1EW2 (3D)

1ZEB (3D)

1ZED (3D)

1ZEF (3D)

2GLQ (3D)

Secondary accessions: P05188 P06861 Q53S78 Q96DB7

Post-translational modifications:

View phosphorylation sites using PhosphoSite²

REFSEQ proteins: NP_001623.3

ENSEMBL proteins:

ENSP00000375881

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Sigma-Aldrich Proteins and CompoZr ZFN and AQUA Peptides for ALPP
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (Placental alkaline phosphatase (PLAP), Alkaline Phosphatase )
	Human Recombinant Proteins from Abnova (ALPP)

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

4 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005886	plasma membrane	IEA	--
GO:0009986	cell surface	IDA	12493773
GO:0016021	integral to membrane	IEA	--
GO:0031225	anchored to membrane	IEA	--

About this table

Antibodies for ALPP:

	Invitrogen Antibodies for ALPP
	Millipore Mono- and Polyclonal Antibodies for the study of ALPP
	Sigma-Aldrich Antibodies for ALPP
	Browse R&D Systems for Antibodies
	Antibodies from Abcam (Placental alkaline phosphatase (PLAP), Alkaline Phosphatase ), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (ALPP)
	Novus Biologicals Antibodies for ALPP

Assays for ALPP:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry P05187

ProtoNet protein and cluster: P05187

1 Blocks protein family: IPB001952 Alkaline phosphatase

UniProtKB/Swiss-Prot: PPB1_HUMAN, P05187

Similarity: Belongs to the alkaline phosphatase family

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (ALPP)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (ALPP)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_001632

Applied Biosystems Silencer® siRNAs for ALPP

Sigma-Aldrich siRNA and siRNA Panels for ALPP

Sigma-Aldrich shRNA Panels and shRNA for ALPP

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for ALPP
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_001632
Myc/DDK tagged cDNA clone in CMV expression vector: NM_001632
untagged cDNA clone in CMV expression vector: NM_001632

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_001632

UniProtKB/Swiss-Prot: PPB1_HUMAN, P05187

Catalytic activity: A phosphate monoester + H(2)O = an alcohol + phosphate

Enzyme Number (IUBMB): EC 3.1.3.1

Genatlas biochemistry entry for ALPP:

phosphatase alkaline,placental (Regan isozyme)

4 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000287	magnesium ion binding	IEA	--
GO:0004035	alkaline phosphatase activity	NAS	3042787
GO:0008270	zinc ion binding	IEA	--
GO:0016787	hydrolase activity	IEA	--

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

1 Sigma-Aldrich "Your Favorite Gene" Pathway for ALPP (Your Favorite Gene powered by Ingenuity)

Folate Biosynthesis

GeneDecks ALPP for the pathways selected above

About GeneDecksing

Gene Network Central^TM Interacting Genes and Proteins Network for ALPP

5/41 Interacting proteins for ALPP (P05187²) via UniProtKB, MINT, and/or STRING (see all 41 )
Interactant Interaction Details
GeneCard External ID(s)
A2M P01023² MINT-4054731
ACTB P60709² MINT-4054731
APOD P05090² MINT-4054731
ARL8B Q9NVJ2² MINT-4054731
ASAH1 Q13510² MINT-4054731
About this table
1 Gene Ontology (GO) biological process term (links to tree view):
GO ID Qualified GO term Evidence PubMed IDs
GO:0008152 metabolic process IEA --
About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Sigma-Aldrich Small Molecules for ALPP:

Inhibitor

Browse Tocris compounds for ALPP
10/39 Novoseek chemical compound relationships for ALPP gene (see all 39 )

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
alizarin	79.05	29	16546826 (2), 16845965 (2), 18228270 (2), 16530029 (1) (see all 21)
p-nitrophenyl phosphate	72.70	28	15895474 (2), 11816056 (1), 8222223 (1), 8034777 (1) (see all 19)
deoxypyridinoline	69.73	71	15050907 (4), 8911707 (3), 14727010 (2), 15166484 (2) (see all 33)
akermanite	69.41	2	16904740 (1)
hydroxyapatite	65.63	60	12740096 (3), 18270806 (2), 19012271 (2), 17380293 (2) (see all 33)
amppd	65.03	7	18402780 (1), 18452138 (1), 16643808 (1), 17719901 (1)
pyridinoline	63.64	33	10541322 (1), 15860920 (1), 9738702 (1), 14727010 (1) (see all 15)
phenylphosphate	61.63	7	15620894 (1), 9823722 (1), 9140440 (1), 17723415 (1) (see all 5)
titanium	61.36	26	16857255 (3), 15735901 (3), 19290435 (2), 12656459 (2) (see all 12)
cd 2019	60.68	3	8216300 (3)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (ALPP)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (ALPP)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_001632

Sigma-Aldrich siRNA and siRNA Panels for ALPP

Sigma-Aldrich shRNA Panels and shRNA for ALPP

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_001632

REFSEQ mRNAs for ALPP gene:

NM_001632.3

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_001632

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_001632
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_001632
                                 untagged cDNA clone in CMV expression vector: NM_001632

Additional cDNA sequence:

AF217992.1 AK075432.1 BC009647.1 BC068501.1 BC094743.1 CR599162.1 CR621490.1 M12551.1

M14169.1 M14170.1

6 DOTS entries:

DT.100687963 DT.100748673 DT.87016630 DT.95156278 DT.95156286 DT.95156280

24/152 AceView cDNA sequences (see all 152 ):

AL554586 BM742455 CR599162 BX095665 AL553983 AF217992 BM742176 BX439339

R31098 M14169 BM744140 BC068501 CR621490 AL553521 BE549393 X55958

CB959579 H04758 AL549703 M12551 T29404 BM773091 R64663 BG832086

highest scoring ESTs for ALPP:

AA156691 AA367819 AF217992 AI457757 AK075432 AL568578 AL573803 AL576494 AL576838 BC009647

Unigene Cluster for ALPP:

Alkaline phosphatase, placental (Regan isozyme)

Hs.284255 [show with all ESTs]

Unigene Representative Sequence: NM_001632

GeneLoc Exon Structure

1 Ensembl transcript including schematic representation:

ENST00000392027

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

ALPP expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for ALPP

¹ / ² / ³

4 probe-sets matching ALPP gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
204664_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_001632	0.60	0.83	0.73	1
211619_s_at²^{, 3}	U133-A	2	1.00	0.50	--	--	M13077	0.60	0.83	0.73	1
204664_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
211619_s_at²	U133Plus2	2	1.00	0.50	--	--	--	--	--	--	--

About this table

Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: CCAATTTCAG

SOURCE GeneReport for Unigene cluster: Hs.284255

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for ALPP gene from 5/6 species (see all 6 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
chimpanzee (Pan troglodytes)	ALPPL2¹	--	alkaline phosphatase, placental-like 2	97.13(n) 96.37(a)	470679 XM_001146156.1 XP_001146156.1
cow (Bos taurus)	LOC528262¹	--	intestinal alkaline phosphatase VI	78.82(n) 76.58(a)	528262 XM_606676.3 XP_606676.3
rat (Rattus norvegicus)	RGD1565100¹	--	similar to alkaline phosphatase (EC 3.1.3.1) precursor, more	74.21(n) 70.91(a)	367308 XM_346070.3 XP_346071.3
mouse (Mus musculus)	Akp5¹	--	alkaline phosphatase 5	77.44(n) 75.24(a)	11650 NM_007433.3 NP_031459.3
fruit fly (Drosophila melanogaster)	CG5656³ CG10827¹	78D2³	alkaline phosphatase³ CG10827¹	44(a) (best of 11)³ 54.5(n)¹ 45.58(a)¹	42482¹ NM_142674.2¹ NP_650931.1¹

About this table Species with no ortholog for ALPP

ENSEMBL Gene Tree for ALPP

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for ALPP gene

ALPPL2¹ ² ALPL² ALPI²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

UniProtKB/Swiss-Prot: PPB1_HUMAN, P05187

Polymorphism: Placental ALP is highly polymorphic, there are at least three common alleles

10/174 NCBI SNPs in ALPP are shown (see all 174 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 16)

AB	SNP ID	Valid	Chr 2 pos	Sequence	Recs	AA Chg	Type	More	Recs	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--			--
--	rs3762524^1,2	A,C,F,H	232951081(+)	`ACTGGT/CCCGGC`	1	--	ng5¹		4	EU EA WA	404
--	rs2014683^1,2	A,C,F	232951208(+)	`GCCAGA/GGCAGC`	1	--	ng5¹		1	EA	1484
--	rs1130335^1,2	C,F,H	232951830(+)	`CATCCC/TAGGTA`	1	P/L	mis¹ ese³		5	EA EU WA	1164
--	rs3762526^1,2	C,F,H	232951182(+)	`AAGGTA/CAGATG`	1	--	ng5¹		4	EU EA WA	418
--	rs2741312^1,2	A,C,F	232951018(+)	`TAGTGC/TGAGTG`	1	--	ng5¹		1	EA	1478
	rs7573222^1,2	F,H	232956178(+)	`GTGGAA/CAATAA`	1	--	ng3¹		4	EU EA WA	418
--	rs13026692^1,2	F,H	232952225(+)	`CTGAGA/TTACCC`	1	I/L	mis¹		4	EU EA WA	396
--	rs2853378^1,2	C,F	232953270(+)	`GAAGCA/GCCAGG`	1	R/H	mis¹		1	MN	184
	rs7599982^1,2	F,H	232956117(+)	`GTGAAG/ATCTGA`	1	--	ng3¹		4	EU EA WA	414
--	rs1048988^1,2	F,H	232953174(+)	`GTTTCG/CCATGG`	1	P/R	mis¹ ese³		5	MN EU EA WA	526

About this table

HapMap Linkage Disequilibrium images for ALPP (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 171800

10/94 Novoseek disease relationships for ALPP gene (see all 94 )

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
hypophosphatasia	84.28	26	10451522 (2), 9536930 (2), 2079838 (1), 8675582 (1) (see all 19)
seminoma	78.87	102	2273701 (5), 8653285 (4), 1646453 (3), 17629966 (3) (see all 41)
alkaline phosphatase, elevated serum	78.81	17	19212310 (1), 7723166 (1), 7780263 (1), 11142449 (1) (see all 16)
germinoma	70.62	24	19106497 (2), 1723169 (2), 1966857 (1), 8615089 (1) (see all 14)
osteosarcoma	63.29	40	1651438 (2), 1702922 (2), 9914326 (2), 1611300 (1) (see all 27)
biliary cirrhosis primary	60.91	6	1934501 (1), 1541936 (1), 18084701 (1), 10535881 (1) (see all 6)
yolk sac tumor	59.67	4	10469400 (1), 1690172 (1), 8757478 (1)
bone diseases	59.17	17	1458597 (1), 1940065 (1), 9283233 (1), 7923809 (1) (see all 14)
calcification	57.74	70	16958693 (3), 15974530 (3), 11401534 (3), 18160010 (2) (see all 48)
osteoporosis	56.58	5	12634938 (2), 15207757 (1), 9633020 (1), 18581891 (1)

About this table

Genetic Association Database: ALPP
Human Genome Epidemiology Navigator: ALPP (1 document)

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/1268 PubMed articles for ALPP gene (see all 1268 ):

Products of two common alleles at the locus for human placental alkaline phosphatase differ by seven amino acids. (PubMed id 3461452)^{2, 3, 4} Henthorn P.S....Harris H. (1986)
Cloning, sequencing, and chromosomal localization of human term placental alkaline phosphatase cDNA. (PubMed id 3001717)^{2, 3, 4} Kam W.... Rutter W.J. (1985)
Enzyme polymorphisms, smoking, and human reproduction. A study of human placental alkaline phosphatase. (PubMed id 14595869)^{1, 3, 6} Magrini A....Bottini E. (2003)
Crystal structure of alkaline phosphatase from human placenta at 1.8 A resolution. Implication for a substrate specificity. (PubMed id 11124260)^{1, 3, 4} Le Du M.H.... Stura E.A. (2001)
Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)^{3, 4} Hillier L.W....Wilson R.K. (2005)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)
Function assignment to conserved residues in mammalian alkaline phosphatases. (PubMed id 11937510)^{3, 4} Kozlenkov A.... Millan J.L. (2002)
Site-specific mutations in the COOH-terminus of placental alkaline phosphatase: a single amino acid change converts a phosphatidylinositol-glycan-anchored protein to a secreted protein. (PubMed id 1730777)^{3, 4} Lowe M.E. (1992)
Selectivity of the cleavage/attachment site of phosphatidylinositol- glycan-anchored membrane proteins determined by site-specific mutagenesis at Asp-484 of placental alkaline phosphatase. (PubMed id 2153284)^{3, 4} Micanovic R.... Udenfriend S. (1990)
Aspartic acid-484 of nascent placental alkaline phosphatase condenses with a phosphatidylinositol glycan to become the carboxyl terminus of the mature enzyme. (PubMed id 3422741)^{3, 4} Micanovic R.... Udenfriend S. (1988)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 250	HGNC: 439	AceView: ALPPandALPPL2	Ensembl:ENSG00000163283	euGenes: HUgn250
ECgene: ALPP	H-InvDB: ALPP

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
Wikipedia	http://en.wikipedia.org/wiki/Alkaline_phosphatase

Licensable Technologies for ALPP
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for ALPP:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for ALPP-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for ALPP		Antibodies for ALPP
	Explore super-pooled esiRNAs		Proteins for ALPP
	Lentivirus-delivered shRNAs for ALPP		Small molecules for ALPP
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Recombinant Proteins (ALPP)
	Antibodies (ALPP)
	Chimera RNAi (ALPP)
	Custom Service for Mouse Mab
	Custom Service for Rabbit Pab from Full-length Protein

Search for Antibodies & Assays

	Recombinant Proteins (Placental alkaline phosphatase (PLAP), Alkaline Phosphatase )
	Antibodies (Placental alkaline phosphatase (PLAP), Alkaline Phosphatase )

Search OriGene for ALPP

Search Tocris compounds for ALPP

Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Antibodies for ALPP

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ALPP Gene

protein-coding GIFtS: 59

Aliases &
Descriptions
for ALPP

Summaries
for ALPP

Genomic Location
for ALPP

Proteins
for ALPP

Protein Domains/
Families
for ALPP

Gene Function
for ALPP

Pathways & Interactions
for ALPP

Drugs & Compounds
for ALPP

Transcripts
for ALPP

Expression
for ALPP

Orthologs
for ALPP

Paralogs
for ALPP

SNPs/Variants
for ALPP

Disorders & Mutations
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Medical News
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Publications
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Genome Databases showing ALPP

Other Databases showing ALPP

Specialized Databases showing ALPP

Licensable Technologies
for ALPP

Services
for ALPP

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

ALPP Gene

protein-coding GIFtS: 59

Aliases & Descriptionsfor ALPP

Summariesfor ALPP

Genomic Locationfor ALPP

Proteinsfor ALPP

Protein Domains/Familiesfor ALPP

Gene Functionfor ALPP

Pathways & Interactionsfor ALPP

Drugs & Compoundsfor ALPP

Transcriptsfor ALPP

Expression for ALPP

Orthologsfor ALPP

Paralogsfor ALPP

SNPs/Variantsfor ALPP

Disorders & Mutationsfor ALPP

Medical Newsfor ALPP

Publicationsfor ALPP

Search for ALPP

Genome Databases showing ALPP

Other Databases showing ALPP

Specialized Databases showing ALPP

Licensable Technologiesfor ALPP

Servicesfor ALPP

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for ALPP

Summaries
for ALPP

Genomic Location
for ALPP

Proteins
for ALPP

Protein Domains/
Families
for ALPP

Gene Function
for ALPP

Pathways & Interactions
for ALPP

Drugs & Compounds
for ALPP

Transcripts
for ALPP

Expression
for ALPP

Orthologs
for ALPP

Paralogs
for ALPP

SNPs/Variants
for ALPP

Disorders & Mutations
for ALPP

Medical News
for ALPP

Publications
for ALPP

Licensable Technologies
for ALPP

Services
for ALPP