Aliases for ALPP Gene
External Ids for ALPP Gene
Previous GeneCards Identifiers for ALPP Gene
The protein encoded by this gene is an alkaline phosphatase, a metalloenzyme that catalyzes the hydrolysis of phosphoric acid monoesters. It belongs to a multigene family composed of four alkaline phosphatase isoenzymes. The enzyme functions as a homodimer and has a catalytic site containing one magnesium and two zinc ions, which are required for its enzymatic function. The protein is primarily expressed in placental and endometrial tissue; however, strong ectopic expression has been detected in ovarian adenocarcinoma, serous cystadenocarcinoma, and other ovarian cancer cells. [provided by RefSeq, Jan 2015]
GeneCards Summary for ALPP Gene
ALPP (Alkaline Phosphatase, Placental) is a Protein Coding gene. Diseases associated with ALPP include Obstructive Jaundice and Hypophosphatasia. Among its related pathways are Golgi-to-ER retrograde transport and Pyrimidine metabolism (KEGG). GO annotations related to this gene include magnesium ion binding and alkaline phosphatase activity. An important paralog of this gene is ALPPL2.