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Aliases for ALPK3 Gene

Aliases for ALPK3 Gene

  • Alpha Kinase 3 2 3 5
  • Myocyte Induction Differentiation Originator 2 3
  • Muscle Alpha-Protein Kinase 3 4
  • Muscle Alpha-Kinase 2 3
  • MAK 3 4
  • Alpha-Kinase 3 3
  • EC 2.7.11.- 4
  • KIAA1330 4
  • MIDORI 3

External Ids for ALPK3 Gene

Previous GeneCards Identifiers for ALPK3 Gene

  • GC15P083161
  • GC15P085359
  • GC15P061446

Summaries for ALPK3 Gene

GeneCards Summary for ALPK3 Gene

ALPK3 (Alpha Kinase 3) is a Protein Coding gene. GO annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein serine/threonine kinase activity. An important paralog of this gene is ALPK2.

UniProtKB/Swiss-Prot for ALPK3 Gene

  • Kinase that recognizes phosphorylation sites in which the surrounding peptides have an alpha-helical conformation. Plays a role in cardiomyocyte differentiation (By similarity).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ALPK3 Gene

Genomics for ALPK3 Gene

Regulatory Elements for ALPK3 Gene

Enhancers for ALPK3 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around ALPK3 on UCSC Golden Path with GeneCards custom track

Promoters for ALPK3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around ALPK3 on UCSC Golden Path with GeneCards custom track

Genomic Location for ALPK3 Gene

Chromosome:
15
Start:
84,816,680 bp from pter
End:
84,873,482 bp from pter
Size:
56,803 bases
Orientation:
Plus strand

Genomic View for ALPK3 Gene

Genes around ALPK3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ALPK3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ALPK3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ALPK3 Gene

Proteins for ALPK3 Gene

  • Protein details for ALPK3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96L96-ALPK3_HUMAN
    Recommended name:
    Alpha-protein kinase 3
    Protein Accession:
    Q96L96
    Secondary Accessions:
    • Q9P2L6

    Protein attributes for ALPK3 Gene

    Size:
    1907 amino acids
    Molecular mass:
    201272 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ALPK3 Gene

Proteomics data for ALPK3 Gene at MOPED

Post-translational modifications for ALPK3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ALPK3 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ALPK3 Gene

Domains & Families for ALPK3 Gene

Suggested Antigen Peptide Sequences for ALPK3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q96L96

UniProtKB/Swiss-Prot:

ALPK3_HUMAN :
  • Contains 1 alpha-type protein kinase domain.
  • Belongs to the protein kinase superfamily. Alpha-type protein kinase family. ALPK subfamily.
Domain:
  • Contains 1 alpha-type protein kinase domain.
  • Contains 2 Ig-like (immunoglobulin-like) domains.
Family:
  • Belongs to the protein kinase superfamily. Alpha-type protein kinase family. ALPK subfamily.
genes like me logo Genes that share domains with ALPK3: view

Function for ALPK3 Gene

Molecular function for ALPK3 Gene

UniProtKB/Swiss-Prot Function:
Kinase that recognizes phosphorylation sites in which the surrounding peptides have an alpha-helical conformation. Plays a role in cardiomyocyte differentiation (By similarity).

Enzyme Numbers (IUBMB) for ALPK3 Gene

Gene Ontology (GO) - Molecular Function for ALPK3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004674 protein serine/threonine kinase activity IEA --
GO:0005524 ATP binding IEA --
genes like me logo Genes that share ontologies with ALPK3: view
genes like me logo Genes that share phenotypes with ALPK3: view

Animal Model Products

  • Taconic Biosciences Mouse Models for ALPK3

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ALPK3 Gene

Localization for ALPK3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ALPK3 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ALPK3 Gene COMPARTMENTS Subcellular localization image for ALPK3 gene
Compartment Confidence
nucleus 5
cytosol 2
peroxisome 1

No data available for Gene Ontology (GO) - Cellular Components for ALPK3 Gene

Pathways & Interactions for ALPK3 Gene

SuperPathways for ALPK3 Gene

No Data Available

Interacting Proteins for ALPK3 Gene

Selected Interacting proteins: Q96L96-ALPK3_HUMAN for ALPK3 Gene via I2D

Symbol External ID(s) Details
MYC

Gene Ontology (GO) - Biological Process for ALPK3 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for ALPK3 Gene

Drugs & Compounds for ALPK3 Gene

No Compound Related Data Available

Transcripts for ALPK3 Gene

mRNA/cDNA for ALPK3 Gene

Unigene Clusters for ALPK3 Gene

Alpha-kinase 3:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ALPK3 Gene

No ASD Table

Relevant External Links for ALPK3 Gene

GeneLoc Exon Structure for
ALPK3
ECgene alternative splicing isoforms for
ALPK3

Expression for ALPK3 Gene

mRNA expression in normal human tissues for ALPK3 Gene

mRNA differential expression in normal tissues according to GTEx for ALPK3 Gene

This gene is overexpressed in Muscle - Skeletal (x19.3) and Heart - Left Ventricle (x7.5).

Protein differential expression in normal tissues from HIPED for ALPK3 Gene

This gene is overexpressed in Cervix (62.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ALPK3 Gene



SOURCE GeneReport for Unigene cluster for ALPK3 Gene Hs.459183

genes like me logo Genes that share expression patterns with ALPK3: view

Protein tissue co-expression partners for ALPK3 Gene

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for ALPK3 Gene

Orthologs for ALPK3 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ALPK3 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia ALPK3 35
  • 81.23 (n)
  • 76.1 (a)
ALPK3 36
  • 74 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ALPK3 35
  • 83.18 (n)
  • 77.67 (a)
ALPK3 36
  • 75 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Alpk3 35
  • 79.18 (n)
  • 74.65 (a)
Alpk3 16
Alpk3 36
  • 71 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia ALPK3 35
  • 96.44 (n)
  • 94.66 (a)
ALPK3 36
  • 97 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Alpk3 35
  • 79.84 (n)
  • 74.76 (a)
oppossum
(Monodelphis domestica)
Mammalia ALPK3 36
  • 55 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ALPK3 36
  • 70 (a)
OneToOne
chicken
(Gallus gallus)
Aves ALPK3 36
  • 39 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ALPK3 36
  • 38 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii alpk3a 36
  • 27 (a)
OneToMany
BX001033.2 36
  • 20 (a)
OneToMany
Species with no ortholog for ALPK3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ALPK3 Gene

ENSEMBL:
Gene Tree for ALPK3 (if available)
TreeFam:
Gene Tree for ALPK3 (if available)

Paralogs for ALPK3 Gene

Paralogs for ALPK3 Gene

genes like me logo Genes that share paralogs with ALPK3: view

Variants for ALPK3 Gene

Sequence variations from dbSNP and Humsavar for ALPK3 Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type
rs3803403 - 84,839,914(+) CGACA(C/G)TCTGC reference, missense
rs3803405 - 84,840,409(+) ACGGG(A/G)GCCTG reference, missense
rs16974569 - 84,856,414(+) AACCA(C/T)GGCTC reference, missense
rs306197 - 84,858,028(-) CCTCA(A/G)GGGAA reference, missense
rs187316 - 84,862,764(+) TGGCC(C/T)TCGGA reference, missense

Structural Variations from Database of Genomic Variants (DGV) for ALPK3 Gene

Variant ID Type Subtype PubMed ID
esv2672879 CNV Deletion 23128226
dgv770e1 CNV Complex 17122850
nsv524050 CNV Loss 19592680
dgv322n27 CNV Gain 19166990
nsv471257 CNV Gain 18288195

Variation tolerance for ALPK3 Gene

Residual Variation Intolerance Score: 39% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 10.55; 91.19% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for ALPK3 Gene

Disorders for ALPK3 Gene

Relevant External Links for ALPK3

Genetic Association Database (GAD)
ALPK3
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ALPK3

No disorders were found for ALPK3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ALPK3 Gene

Publications for ALPK3 Gene

  1. Alpha-kinases: a new class of protein kinases with a novel catalytic domain. (PMID: 10021370) Ryazanov A.G. … Dorovkov M.V. (Curr. Biol. 1999) 2 3 4 67
  2. Genome-wide association study of chemotherapeutic agent-induced severe neutropenia/leucopenia for patients in Biobank Japan. (PMID: 23648065) Low S.K. … Nakamura Y. (Cancer Sci. 2013) 3
  3. Genome-wide association analysis of age-at-onset in Alzheimer's disease. (PMID: 22005931) Kamboh M.I. … Lopez O.L. (Mol. Psychiatry 2012) 3
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3

Products for ALPK3 Gene

Sources for ALPK3 Gene

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