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Aliases for ALPK3 Gene

Aliases for ALPK3 Gene

  • Alpha-Kinase 3 2 3
  • Myocyte Induction Differentiation Originator 2 3
  • Muscle Alpha-Protein Kinase 3 4
  • Muscle Alpha-Kinase 2 3
  • MAK 3 4
  • Alpha-Protein Kinase 3 3
  • EC 2.7.11.- 4
  • KIAA1330 4
  • MIDORI 3

External Ids for ALPK3 Gene

Summaries for ALPK3 Gene

GeneCards Summary for ALPK3 Gene

ALPK3 (Alpha-Kinase 3) is a Protein Coding gene. Among its related pathways are Coregulation of Androgen receptor activity. GO annotations related to this gene include protein serine/threonine kinase activity. An important paralog of this gene is ALPK2.

UniProtKB/Swiss-Prot for ALPK3 Gene

  • Kinase that recognizes phosphorylation sites in which the surrounding peptides have an alpha-helical conformation. Plays a role in cardiomyocyte differentiation (By similarity).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ALPK3 Gene

Genomics for ALPK3 Gene

Genomic Location for ALPK3 Gene

Start:
84,816,680 bp from pter
End:
84,873,482 bp from pter
Size:
56,803 bases
Orientation:
Plus strand

Genomic View for ALPK3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ALPK3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ALPK3 Gene

Regulatory Elements for ALPK3 Gene

Proteins for ALPK3 Gene

  • Protein details for ALPK3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96L96-ALPK3_HUMAN
    Recommended name:
    Alpha-protein kinase 3
    Protein Accession:
    Q96L96
    Secondary Accessions:
    • Q9P2L6

    Protein attributes for ALPK3 Gene

    Size:
    1907 amino acids
    Molecular mass:
    201272 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ALPK3 Gene

Proteomics data for ALPK3 Gene at MOPED

Post-translational modifications for ALPK3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ALPK3 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ALPK3 Gene

Domains for ALPK3 Gene

Gene Families for ALPK3 Gene

HGNC:
  • ISET :Immunoglobulin superfamily / I-set domain containing
  • IGD :Immunoglobulin superfamily / Immunoglobulin-like domain containing
IUPHAR :

Suggested Antigen Peptide Sequences for ALPK3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q96L96

UniProtKB/Swiss-Prot:

ALPK3_HUMAN
Domain:
  • Contains 1 alpha-type protein kinase domain.:
    • Q96L96
  • Contains 2 Ig-like (immunoglobulin-like) domains.:
    • Q96L96
Family:
  • Belongs to the protein kinase superfamily. Alpha-type protein kinase family. ALPK subfamily.:
    • Q96L96
genes like me logo Genes that share domains with ALPK3: view

Function for ALPK3 Gene

Molecular function for ALPK3 Gene

UniProtKB/Swiss-Prot Function: Kinase that recognizes phosphorylation sites in which the surrounding peptides have an alpha-helical conformation. Plays a role in cardiomyocyte differentiation (By similarity).

Enzyme Numbers (IUBMB) for ALPK3 Gene

Gene Ontology (GO) - Molecular Function for ALPK3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004674 protein serine/threonine kinase activity IEA --
GO:0005515 protein binding --
GO:0005524 ATP binding IEA --
GO:0016772 transferase activity, transferring phosphorus-containing groups --
genes like me logo Genes that share ontologies with ALPK3: view

Phenotypes for ALPK3 Gene

GenomeRNAi human phenotypes for ALPK3:
genes like me logo Genes that share phenotypes with ALPK3: view

miRNA for ALPK3 Gene

miRTarBase miRNAs that target ALPK3

No data available for Animal Models , Transcription Factor Targeting and HOMER Transcription for ALPK3 Gene

Localization for ALPK3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ALPK3 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ALPK3 Gene COMPARTMENTS Subcellular localization image for ALPK3 gene
Compartment Confidence
nucleus 3
cytosol 2
peroxisome 1

Gene Ontology (GO) - Cellular Components for ALPK3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus ISS --
genes like me logo Genes that share ontologies with ALPK3: view

Pathways for ALPK3 Gene

genes like me logo Genes that share pathways with ALPK3: view

Pathways by source for ALPK3 Gene

1 BioSystems pathway for ALPK3 Gene

Interacting Proteins for ALPK3 Gene

Selected Interacting proteins: Q96L96-ALPK3_HUMAN for ALPK3 Gene via I2D

Symbol External ID(s) Details
MYC

Gene Ontology (GO) - Biological Process for ALPK3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006468 protein phosphorylation IEA --
GO:0007507 heart development ISS --
genes like me logo Genes that share ontologies with ALPK3: view

Transcripts for ALPK3 Gene

mRNA/cDNA for ALPK3 Gene

Unigene Clusters for ALPK3 Gene

Alpha-kinase 3:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ALPK3 Gene

No ASD Table

Relevant External Links for ALPK3 Gene

GeneLoc Exon Structure for
ALPK3
ECgene alternative splicing isoforms for
ALPK3

Expression for ALPK3 Gene

mRNA expression in normal human tissues for ALPK3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ALPK3 Gene

This gene is overexpressed in Muscle - Skeletal (19.3) and Heart - Left Ventricle (7.5).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for ALPK3 Gene

SOURCE GeneReport for Unigene cluster for ALPK3 Gene Hs.459183

genes like me logo Genes that share expressions with ALPK3: view

No data available for mRNA Expression by UniProt/SwissProt for ALPK3 Gene

Orthologs for ALPK3 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ALPK3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ALPK3 35
  • 96.44 (n)
  • 94.66 (a)
ALPK3 36
  • 97 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ALPK3 35
  • 81.23 (n)
  • 76.1 (a)
ALPK3 36
  • 74 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ALPK3 35
  • 83.18 (n)
  • 77.67 (a)
ALPK3 36
  • 75 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Alpk3 35
  • 79.18 (n)
  • 74.65 (a)
Alpk3 16
Alpk3 36
  • 71 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ALPK3 36
  • 55 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ALPK3 36
  • 70 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Alpk3 35
  • 79.84 (n)
  • 74.76 (a)
chicken
(Gallus gallus)
Aves ALPK3 36
  • 39 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ALPK3 36
  • 38 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii alpk3a 36
  • 27 (a)
OneToMany
BX001033.2 36
  • 20 (a)
OneToMany
Species with no ortholog for ALPK3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ALPK3 Gene

ENSEMBL:
Gene Tree for ALPK3 (if available)
TreeFam:
Gene Tree for ALPK3 (if available)

Paralogs for ALPK3 Gene

Paralogs for ALPK3 Gene

genes like me logo Genes that share paralogs with ALPK3: view

Variants for ALPK3 Gene

Sequence variations from dbSNP and Humsavar for ALPK3 Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type MAF
rs167379 -- 84,858,188(-) GGGAG(A/G)CCTGT synonymous-codon, reference
rs182516 -- 84,859,180(+) ACCCA(A/G)GAGAG intron-variant
rs182517 -- 84,846,400(+) catct(A/G)acttt intron-variant
rs186266 -- 84,859,564(+) AAGCC(A/G)CTTGT intron-variant
rs187316 - 84,862,764(+) TGGCC(C/T)TCGGA missense, reference

Structural Variations from Database of Genomic Variants (DGV) for ALPK3 Gene

Variant ID Type Subtype PubMed ID
esv2672879 CNV Deletion 23128226
dgv770e1 CNV Complex 17122850
nsv524050 CNV Loss 19592680
dgv322n27 CNV Gain 19166990
nsv471257 CNV Gain 18288195

Relevant External Links for ALPK3 Gene

HapMap Linkage Disequilibrium report
ALPK3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ALPK3 Gene

Disorders for ALPK3 Gene

Relevant External Links for ALPK3

Genetic Association Database (GAD)
ALPK3
genes like me logo Genes that share disorders with ALPK3: view

No data available for UniProtKB/Swiss-Prot for ALPK3 Gene

Publications for ALPK3 Gene

  1. Alpha-kinases: a new class of protein kinases with a novel catalytic domain. (PMID: 10021370) Ryazanov A.G. … Dorovkov M.V. (Curr. Biol. 1999) 2 3 4
  2. Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10718198) Nagase T. … Ohara O. (DNA Res. 2000) 3 4
  3. A novel myocyte-specific gene Midori promotes the differentiation of P19CL6 cells into cardiomyocytes. (PMID: 11418590) Hosoda T. … Komuro I. (J. Biol. Chem. 2001) 3
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3

Products for ALPK3 Gene

Sources for ALPK3 Gene

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