Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



ALPK2 Gene

protein-coding   GIFtS: 44
GCID: GC18M056148

Alpha-Kinase 2

  Search for ALPK2
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Alpha-Kinase 21 2
Heart Alpha-Kinase1 2
Heart Alpha-Protein Kinase2 3
HAK2 3
Alpha-Protein Kinase 22
EC 2.7.11.-3

External Ids:    HGNC: 205651   Entrez Gene: 1157012   Ensembl: ENSG000001987967   UniProtKB: Q86TB33   

Export aliases for ALPK2 gene to outside databases

Previous GC identifers: GC18M054300 GC18M052856


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

GeneCards Summary for ALPK2 Gene:
ALPK2 (alpha-kinase 2) is a protein-coding gene. GO annotations related to this gene include protein serine/threonine kinase activity. An important paralog of this gene is ALPK3.

UniProtKB/Swiss-Prot: ALPK2_HUMAN, Q86TB3
Function: Kinase that recognizes phosphorylation sites in which the surrounding peptides have an alpha-helical
conformation




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence at NCBI GenBank:
NC_000018.9  NT_010966.15  NC_018929.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the ALPK2 gene promoter:
         CBF-C   PPAR-gamma1   CBF-B   CBF-A   HOXA5   FOXJ2 (long isoform)   CP1A   PPAR-gamma2   FOXJ2   CBF(2)   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): ALPK2 promoter sequence
   Search Chromatin IP Primers for ALPK2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ALPK2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 18q21.31   Ensembl cytogenetic band:  18q21.32   HGNC cytogenetic band: 18q21.31

ALPK2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ALPK2 gene location

GeneLoc information about chromosome 18         GeneLoc Exon Structure

GeneLoc location for GC18M056148:  view genomic region     (about GC identifiers)

Start:
56,148,479 bp from pter      End:
56,296,189 bp from pter
Size:
147,711 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: ALPK2_HUMAN, Q86TB3 (See protein sequence)
Recommended Name: Alpha-protein kinase 2  
Size: 2170 amino acids; 237013 Da
Sequence caution: Sequence=AAK95952.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Sequence=AAK95952.1; Type=Miscellaneous discrepancy; Note=Aberrant splicing; Sequence=BAC03812.1; Type=Erroneous
initiation; Note=Translation N-terminally extended; Sequence=BAC03812.1; Type=Miscellaneous discrepancy;
Note=Aberrant splicing; Sequence=BX647796; Type=Miscellaneous discrepancy; Note=Aberrant splicing;
Sequence=CAD89922.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Secondary accessions: Q6ZUX0 Q8NAT5 Q96L95

Explore the universe of human proteins at neXtProt for ALPK2: NX_Q86TB3

Explore proteomics data for ALPK2 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See ALPK2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_443179.3  
    ENSEMBL proteins: 
     ENSP00000354991  

    ALPK2 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    Browse OriGene Protein Over-expression Lysates
    OriGene Custom MassSpec
    OriGene Custom Protein Services for ALPK2
    GenScript Custom Purified and Recombinant Proteins Services for ALPK2
    Novus Biologicals ALPK2 Protein
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp.

     
    Search eBioscience for Proteins for ALPK2 

    ALPK2 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    OriGene Antibodies for ALPK2
    OriGene Custom Antibody Services for ALPK2
    Novus Biologicals ALPK2 Antibodies
    Abcam antibodies for ALPK2
    Browse Antibodies at Cloud-Clone Corp.
    Search ThermoFisher Antibodies for ALPK2
    LSBio Antibodies in human, mouse, rat for ALPK2

    ALPK2 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for ALPK2
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for ALPK2
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.
    Search eBioscience for ELISAs for ALPK2 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    HGNC Gene Families:
    ISET: Immunoglobulin superfamily / I-set domain containing

    Selected InterPro protein domains (see all 7):
     IPR003598 Ig_sub2
     IPR013098 Ig_I-set
     IPR011009 Kinase-like_dom
     IPR013783 Ig-like_fold
     IPR004166 MHCK_EF2_kinase

    Graphical View of Domain Structure for InterPro Entry Q86TB3

    ProtoNet protein and cluster: Q86TB3

    UniProtKB/Swiss-Prot: ALPK2_HUMAN, Q86TB3
    Similarity: Belongs to the protein kinase superfamily. Alpha-type protein kinase family. ALPK subfamily
    Similarity: Contains 1 alpha-type protein kinase domain
    Similarity: Contains 2 Ig-like (immunoglobulin-like) domains


    Find genes that share domains with ALPK2           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ALPK2_HUMAN, Q86TB3
    Function: Kinase that recognizes phosphorylation sites in which the surrounding peptides have an alpha-helical
    conformation

         Enzyme Number (IUBMB): EC 2.7.11.-1

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004674protein serine/threonine kinase activity IEA--
    GO:0005515protein binding ----
    GO:0005524ATP binding IEA--
    GO:0016772transferase activity, transferring phosphorus-containing groups ----
         
    Find genes that share ontologies with ALPK2           About GenesLikeMe


    Phenotypes:
         5 GenomeRNAi human phenotypes for ALPK2:
     Decreased focal adhesion (FA)   Decreased substrate adherent c  Gemcitabine induced cell-death  Increased apoptosis 
     Upregulation of Wnt/beta-caten 

         1 MGI phenotypic allele for Alpk2 (no phenotypes)

    Find genes that share phenotypes with ALPK2           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Alpk2tm1Lex for ALPK2

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for ALPK2
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for ALPK2

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for ALPK2
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for ALPK2

    miRNA
    Products:
        
    Block miRNA regulation of human, mouse, rat ALPK2 using miScript Target Protectors
    2 qRT-PCR Assays for microRNAs that regulate ALPK2:
    hsa-miR-19b hsa-miR-19a
    SwitchGear 3'UTR luciferase reporter plasmidALPK2 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for ALPK2
    Predesigned siRNA for gene silencing in human, mouse, rat ALPK2

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for ALPK2

    Clone
    Products:
         
    OriGene clones in human, mouse for ALPK2 (see all 7)
    OriGene ORF clones in mouse, rat for ALPK2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: ALPK2 (NM_052947)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ALPK2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ALPK2
    Addgene plasmids for ALPK2 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for ALPK2
    Browse ESI BIO Cell Lines and PureStem Progenitors for ALPK2 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ALPK2


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol2
    nucleus2

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005730NOT nucleolus IDA--

    Find genes that share ontologies with ALPK2           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus



        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for ALPK2
    Interactions:

        Search GeneGlobe Interaction Network for ALPK2

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006468protein phosphorylation ----

    Find genes that share ontologies with ALPK2           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ALPK2



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for ALPK2 gene: 
    NM_052947.3  

    Unigene Cluster for ALPK2:

    Alpha-kinase 2
    Hs.628152  [show with all ESTs]
    Unigene Representative Sequence: BX647796
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000361673(uc002lhj.4 uc002lhk.1) ENST00000589204 ENST00000587842
    ENST00000587399 ENST00000590662 ENST00000590642
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat ALPK2 using miScript Target Protectors
    2 qRT-PCR Assays for microRNAs that regulate ALPK2:
    hsa-miR-19b hsa-miR-19a
    SwitchGear 3'UTR luciferase reporter plasmidALPK2 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for ALPK2
    Predesigned siRNA for gene silencing in human, mouse, rat ALPK2
    Clone
    Products:
         
    OriGene clones in human, mouse for ALPK2 (see all 7)
    OriGene ORF clones in mouse, rat for ALPK2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: ALPK2 (NM_052947)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ALPK2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ALPK2
    Addgene plasmids for ALPK2 
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for ALPK2
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat ALPK2
      QuantiTect SYBR Green Assays in human, mouse, rat ALPK2
      QuantiFast Probe-based Assays in human, mouse, rat ALPK2

    Additional mRNA sequence: 

    AK092133.1 AK092194.1 AK125243.1 AL832018.2 AY044450.1 BX647446.1 BX647639.1 BX647796.1 

    6 DOTS entries:

    DT.91685353  DT.75160056  DT.101965645  DT.408049  DT.91981470  DT.95240125 

    Selected AceView cDNA sequences (see all 59):

    BE551416 CN483959 AW732327 BQ002209 AI796293 AI015219 AA347019 BM717573 
    AI004225 AI743679 NM_052947 AA345241 BM674841 AY044450 AI433756 AK092194 
    AA262326 AK125243 AX747403 BG752968 BX647446 BF431951 BX647639 AL832018 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    ALPK2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GTTGTGCTGT
    ALPK2 Expression
    About this image


    ALPK2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 10) fully expand
     
     Umbilical Cord (Extraembryonic Tissues)    fully expand to see all 2 entries
             Umbilical cord-derived mesenchymal stem cells (family)
     
     Mesenchymal Stem Cells (Uncategorized)    fully expand to see all 2 entries
             Umbilical cord-derived mesenchymal stem cells (family)
     
     NULL (Uncategorized)
             Mesoderm-like cells
     
     Neural Ectoderm (Nervous System)
             Neural ectoderm cells
     
     Heart (Cardiovascular System)
             Cardiomyocyte-like progenitor cells
    ALPK2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ALPK2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.628152
        Custom PCR Arrays for ALPK2
    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for ALPK2
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat ALPK2
    QuantiTect SYBR Green Assays in human, mouse, rat ALPK2
    QuantiFast Probe-based Assays in human, mouse, rat ALPK2
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ALPK2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of chordates.

    Orthologs for ALPK2 gene from Selected species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Alpk21 , 5 alpha-kinase 21, 5 71.26(n)1
    57.24(a)1
      18 (38.41 cM)5
    2256381  NM_001037294.11  NP_001032371.11 
     652655295 
    chicken
    (Gallus gallus)
    Aves ALPK26
    alpha-kinase 2
    75(a)
    1 ↔ 1
    Z(767645-796574)
    lizard
    (Anolis carolinensis)
    Reptilia ALPK26
    alpha-kinase 2
    59(a)
    1 ↔ 1
    GL343213.1(2703710-2780328)
    zebrafish
    (Danio rerio)
    Actinopterygii alpk26
    alpha-kinase 2
    27(a)
    1 ↔ 1
    21(9401740-9415884) ENSDARG00000079637


    ENSEMBL Gene Tree for ALPK2 (if available)
    TreeFam Gene Tree for ALPK2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for ALPK2 gene
    ALPK32  

    Find genes that share paralogs with ALPK2           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for ALPK2 (see all 3535)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 18 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0455944
    A melanoma metastatic sample4--see VAR_0455942 K T mis40--------
    VAR_0455914
    An ovarian undifferentiated carcinoma sample4--see VAR_0455912 E K mis40--------
    rs2019387491,2
    Cuntested156204899(+) AGTTCC/TGTATC 2 T syn11Minor allele frequency- T:0.00EU 1313
    rs741832711,2
    C--52940822(+) TTTTG-/TTCC/ 
    TTCCTTCC
    TTCCT
    1 -- int11NA 2
    rs1410118061,2
    --56148061(+) CTTGCC/TCAATT 1 -- ds50010--------
    rs118732211,2
    C,F,H--56148216(+) CCCCCG/ACCAGG 1 -- ds50015Minor allele frequency- A:0.00NS EA NA 412
    rs45537071,2
    C,H--56148244(+) GGCCTG/ACATCT 1 -- ds500117Minor allele frequency- A:0.00NS EA WA NA CSA 789
    rs1450527981,2
    --56148254(+) TTCTGG/TCGCGA 1 -- ds50010--------
    rs747115731,2
    C,F--56148256(+) CTGGCG/ACGATC 1 -- ds50012Minor allele frequency- A:0.14CSA WA 119
    rs353382651,2
    C,F--56148331(+) CCTAAG/ATTGTA 1 -- ds50019Minor allele frequency- A:0.20NA WA CSA EA 369

    HapMap Linkage Disequilibrium report for ALPK2 (56148479 - 56296189 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for ALPK2:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2717161CNV Deletion23290073
    esv2442112CNV Insertion19546169
    nsv521388CNV Loss19592680
    nsv458089CNV Loss19166990
    nsv909667CNV Gain21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing ALPK2
    DNA2.0 Custom Variant and Variant Library Synthesis for ALPK2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus

    Find genes that share disorders with ALPK2           About GenesLikeMe

    Genetic Association Database (GAD): ALPK2
    Human Genome Epidemiology (HuGE) Navigator: ALPK2 (2 documents)

    Export disorders for ALPK2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for ALPK2 gene integrated from 10 sources:
    (articles sorted by number of sources associating them with ALPK2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Alpha-kinases: a new class of protein kinases with a novel catalytic domain. (PubMed id 10021370)1, 2, 3 Ryazanov A.G.... Dorovkov M.V. (Curr. Biol. 1999)
    2. Genetic analysis of diabetic nephropathy on chromosome 18 in African Americans: linkage analysis and dense SNP mapping. (PubMed id 19690890)1, 4 McDonough C.W....Bowden D.W. (Hum. Genet. 2009)
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    4. ALPK2 is crucial for luminal apoptosis and DNA repair-related gene expression in a three-dimensional colonic-crypt model. (PubMed id 22641666)1 Yoshida Y....Shirasawa S. (Anticancer Res. 2012)
    5. Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis. (PubMed id 21833088)1  ....Compston A. (Nature 2011)
    6. Global identification of modular cullin-RING ligase substrates. (PubMed id 21963094)1 Emanuele M.J....Elledge S.J. (Cell 2011)
    7. Patterns of somatic mutation in human cancer genomes. (PubMed id 17344846)2 Greenman C.... Stratton M.R. (Nature 2007)
    8. The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)2 Bechtel S.... Schupp I. (BMC Genomics 2007)
    9. DNA sequence and analysis of human chromosome 18. (PubMed id 16177791)2 Nusbaum C.... Lander E.S. (Nature 2005)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 115701 HGNC: 20565 AceView: HAK Ensembl:ENSG00000198796 euGenes: HUgn115701
    ECgene: ALPK2 H-InvDB: ALPK2

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for ALPK2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for ALPK2 gene:
    Search GeneIP for patents involving ALPK2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for ALPK2   OriGene RNAi products in human, mouse, rat for ALPK2  
     Browse OriGene qPCR primer pairs and template standards   Browse OriGene Protein Over-expression Lysates  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for ALPK2  
     OriGene qSTAR qPCR primer pairs in human, mouse for ALPK2   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for ALPK2   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for ALPK2   OriGene Custom Protein Services for ALPK2  

     
     
     Block miRNA regulation of human, mouse, rat ALPK2 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing ALPK2
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ALPK2 Predesigned siRNA for gene silencing in human, mouse, rat ALPK2
     QuantiFast Probe-based Assays in human, mouse, rat ALPK2 QuantiTect SYBR Green Assays in human, mouse, rat ALPK2
     Custom PCR Arrays for ALPK2 Search Chromatin IP Primers for ALPK2
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat ALPK2  Search GeneGlobe Interaction Network for ALPK2
     Regulatory tfbs in ALPK2 promoter
     GenScript Custom Purified and Recombinant Proteins Services for ALPK2 GenScript cDNA clones with any tag delivered in your preferred vector for ALPK2
     GenScript Custom Assay Services for ALPK2 GenScript Custom overexpressing Cell Line Services for ALPK2
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for ALPK2
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     ALPK2 antibodies
     ALPK2 proteins
     Antibodies for ALPK2
     See all of Abcam's Antibodies, Kits and Proteins for ALPK2
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Browse Proteins at Cloud-Clone Corp.
     Browse Antibodies at Cloud-Clone Corp.
     Browse ELISAs at Cloud-Clone Corp.
     Browse CLIAs at Cloud-Clone Corp.



     Browse ESI BIO Cell Lines and PureStem Progenitors for ALPK2
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ALPK2
     SwitchGear 3'UTR luciferase reporter plasmids for ALPK2
     SwitchGear Promoter luciferase reporter plasmids for ALPK2
     Search ThermoFisher Antibodies for ALPK2
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ALPK2
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for ALPK2
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for ALPK2
     LSBio Antibodies in human, mouse, rat for ALPK2
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
     Addgene plasmids for ALPK2
      Search eBioscience for proteins for ALPK2
      Search eBioscience for elisas for ALPK2
      eBioscience FlowRNA Probe Sets
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      ALPK2 gene at Home site.
    Version: 3.12.212 17 Sep 2014
    hostname: 356980-web2.xennexinc.com index build: 128 solr: 1.4