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Aliases for ALPK2 Gene

Aliases for ALPK2 Gene

  • Alpha Kinase 2 2 3 5
  • Heart Alpha-Protein Kinase 3 4
  • Heart Alpha-Kinase 2 3
  • HAK 3 4
  • Alpha-Kinase 2 3
  • EC 2.7.11.- 4

External Ids for ALPK2 Gene

Previous GeneCards Identifiers for ALPK2 Gene

  • GC18M054300
  • GC18M056148
  • GC18M052856

Summaries for ALPK2 Gene

GeneCards Summary for ALPK2 Gene

ALPK2 (Alpha Kinase 2) is a Protein Coding gene. GO annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein serine/threonine kinase activity. An important paralog of this gene is ALPK3.

UniProtKB/Swiss-Prot for ALPK2 Gene

  • Kinase that recognizes phosphorylation sites in which the surrounding peptides have an alpha-helical conformation.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ALPK2 Gene

Genomics for ALPK2 Gene

Regulatory Elements for ALPK2 Gene

Enhancers for ALPK2 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around ALPK2 on UCSC Golden Path with GeneCards custom track

Genomic Location for ALPK2 Gene

Chromosome:
18
Start:
58,481,247 bp from pter
End:
58,629,188 bp from pter
Size:
147,942 bases
Orientation:
Minus strand

Genomic View for ALPK2 Gene

Genes around ALPK2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ALPK2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ALPK2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ALPK2 Gene

Proteins for ALPK2 Gene

  • Protein details for ALPK2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q86TB3-ALPK2_HUMAN
    Recommended name:
    Alpha-protein kinase 2
    Protein Accession:
    Q86TB3
    Secondary Accessions:
    • Q6ZUX0
    • Q8NAT5
    • Q96L95

    Protein attributes for ALPK2 Gene

    Size:
    2170 amino acids
    Molecular mass:
    237013 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAK95952.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAK95952.1; Type=Miscellaneous discrepancy; Note=Aberrant splicing.; Evidence={ECO:0000305}; Sequence=BAC03812.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAC03812.1; Type=Miscellaneous discrepancy; Note=Aberrant splicing.; Evidence={ECO:0000305}; Sequence=BX647796; Type=Miscellaneous discrepancy; Note=Aberrant splicing.; Evidence={ECO:0000305}; Sequence=CAD89922.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

neXtProt entry for ALPK2 Gene

Proteomics data for ALPK2 Gene at MOPED

Post-translational modifications for ALPK2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ALPK2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ALPK2 Gene

Domains & Families for ALPK2 Gene

Gene Families for ALPK2 Gene

Protein Domains for ALPK2 Gene

Suggested Antigen Peptide Sequences for ALPK2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q86TB3

UniProtKB/Swiss-Prot:

ALPK2_HUMAN :
  • Contains 1 alpha-type protein kinase domain.
  • Belongs to the protein kinase superfamily. Alpha-type protein kinase family. ALPK subfamily.
Domain:
  • Contains 1 alpha-type protein kinase domain.
  • Contains 2 Ig-like (immunoglobulin-like) domains.
Family:
  • Belongs to the protein kinase superfamily. Alpha-type protein kinase family. ALPK subfamily.
genes like me logo Genes that share domains with ALPK2: view

Function for ALPK2 Gene

Molecular function for ALPK2 Gene

UniProtKB/Swiss-Prot Function:
Kinase that recognizes phosphorylation sites in which the surrounding peptides have an alpha-helical conformation.

Enzyme Numbers (IUBMB) for ALPK2 Gene

Gene Ontology (GO) - Molecular Function for ALPK2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004674 protein serine/threonine kinase activity IEA --
GO:0005524 ATP binding IEA --
genes like me logo Genes that share ontologies with ALPK2: view
genes like me logo Genes that share phenotypes with ALPK2: view

Animal Model Products

  • Taconic Biosciences Mouse Models for ALPK2

miRNA for ALPK2 Gene

miRTarBase miRNAs that target ALPK2

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ALPK2 Gene

Localization for ALPK2 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ALPK2 Gene COMPARTMENTS Subcellular localization image for ALPK2 gene
Compartment Confidence
nucleus 5
cytosol 3

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for ALPK2 Gene

Pathways & Interactions for ALPK2 Gene

SuperPathways for ALPK2 Gene

No Data Available

Interacting Proteins for ALPK2 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000354991%0d%0a9606.ENSP00000344818%0d%0a
Selected Interacting proteins: ENSP00000354991 for ALPK2 Gene via STRING

Symbol External ID(s) Details
UBC

Gene Ontology (GO) - Biological Process for ALPK2 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for ALPK2 Gene

Drugs & Compounds for ALPK2 Gene

No Compound Related Data Available

Transcripts for ALPK2 Gene

Unigene Clusters for ALPK2 Gene

Alpha-kinase 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ALPK2 Gene

No ASD Table

Relevant External Links for ALPK2 Gene

GeneLoc Exon Structure for
ALPK2
ECgene alternative splicing isoforms for
ALPK2

Expression for ALPK2 Gene

mRNA expression in normal human tissues for ALPK2 Gene

mRNA differential expression in normal tissues according to GTEx for ALPK2 Gene

This gene is overexpressed in Heart - Left Ventricle (x14.3), Heart - Atrial Appendage (x12.8), and Muscle - Skeletal (x11.1).

Protein differential expression in normal tissues from HIPED for ALPK2 Gene

This gene is overexpressed in Frontal cortex (55.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MOPED, and MaxQB for ALPK2 Gene



SOURCE GeneReport for Unigene cluster for ALPK2 Gene Hs.628152

genes like me logo Genes that share expression patterns with ALPK2: view

Protein tissue co-expression partners for ALPK2 Gene

Primer Products

No data available for mRNA Expression by UniProt/SwissProt for ALPK2 Gene

Orthologs for ALPK2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ALPK2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia ALPK2 35
  • 74.83 (n)
  • 60.63 (a)
ALPK2 36
  • 59 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ALPK2 35
  • 77.28 (n)
  • 63.83 (a)
ALPK2 36
  • 62 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Alpk2 35
  • 71.26 (n)
  • 57.24 (a)
Alpk2 16
Alpk2 36
  • 55 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia ALPK2 35
  • 96.7 (n)
  • 95.55 (a)
ALPK2 36
  • 98 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Alpk2 35
  • 69.89 (n)
  • 55.59 (a)
oppossum
(Monodelphis domestica)
Mammalia ALPK2 36
  • 45 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ALPK2 36
  • 38 (a)
OneToOne
chicken
(Gallus gallus)
Aves ALPK2 36
  • 75 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ALPK2 36
  • 59 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii alpk2 36
  • 27 (a)
OneToOne
Species with no ortholog for ALPK2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ALPK2 Gene

ENSEMBL:
Gene Tree for ALPK2 (if available)
TreeFam:
Gene Tree for ALPK2 (if available)

Paralogs for ALPK2 Gene

Paralogs for ALPK2 Gene

genes like me logo Genes that share paralogs with ALPK2: view

Variants for ALPK2 Gene

Sequence variations from dbSNP and Humsavar for ALPK2 Gene

SNP ID Clin Chr 18 pos Sequence Context AA Info Type
VAR_045591 An ovarian undifferentiated carcinoma sample
rs3809976 -, - 58,537,018(-) TGCAG(G/T)TGGAT nc-transcript-variant, reference, missense
VAR_045594 A melanoma metastatic sample
rs17065127 -, - 58,534,999(+) AATTT(C/T)CTTCT nc-transcript-variant, reference, missense
VAR_054914 -

Structural Variations from Database of Genomic Variants (DGV) for ALPK2 Gene

Variant ID Type Subtype PubMed ID
nsv458089 CNV Loss 19166990
nsv909667 CNV Gain 21882294
nsv521388 CNV Loss 19592680
esv2442112 CNV Insertion 19546169
esv2717161 CNV Deletion 23290073

Variation tolerance for ALPK2 Gene

Residual Variation Intolerance Score: 99.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 27.86; 99.84% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for ALPK2 Gene

Disorders for ALPK2 Gene

Relevant External Links for ALPK2

Genetic Association Database (GAD)
ALPK2
Human Genome Epidemiology (HuGE) Navigator
ALPK2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ALPK2

No disorders were found for ALPK2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ALPK2 Gene

Publications for ALPK2 Gene

  1. Alpha-kinases: a new class of protein kinases with a novel catalytic domain. (PMID: 10021370) Ryazanov A.G. … Dorovkov M.V. (Curr. Biol. 1999) 2 3 4 67
  2. ALPK2 is crucial for luminal apoptosis and DNA repair-related gene expression in a three-dimensional colonic-crypt model. (PMID: 22641666) Yoshida Y. … Shirasawa S. (Anticancer Res. 2012) 3
  3. Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis. (PMID: 21833088) . … Compston A. (Nature 2011) 3
  4. Genetic analysis of diabetic nephropathy on chromosome 18 in African Americans: linkage analysis and dense SNP mapping. (PMID: 19690890) McDonough C.W. … Bowden D.W. (Hum. Genet. 2009) 3
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3

Products for ALPK2 Gene

Sources for ALPK2 Gene

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