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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ALPK2 Gene

protein-coding   GIFtS: 44
GCID: GC18M056148

Alpha-Kinase 2

  See related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Alpha-Kinase 21 2
Heart Alpha-Kinase1 2
Heart Alpha-Protein Kinase2 3
HAK2 3
Alpha-Protein Kinase 22
EC 2.7.11.-3

External Ids:    HGNC: 205651   Entrez Gene: 1157012   Ensembl: ENSG000001987967   UniProtKB: Q86TB33   

Export aliases for ALPK2 gene to outside databases

Previous GC identifers: GC18M054300 GC18M052856


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for ALPK2 Gene: 
ALPK2 (alpha-kinase 2) is a protein-coding gene. Diseases associated with ALPK2 include multiple sclerosis. GO annotations related to this gene include protein serine/threonine kinase activity and ATP binding. An important paralog of this gene is ALPK3.

UniProtKB/Swiss-Prot: ALPK2_HUMAN, Q86TB3
Function: Kinase that recognizes phosphorylation sites in which the surrounding peptides have an alpha-helical
conformation




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000018.9  NT_025028.14  NC_018929.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ALPK2 gene promoter:
         CBF-C   PPAR-gamma1   CBF-B   CBF-A   HOXA5   FOXJ2 (long isoform)   CP1A   PPAR-gamma2   FOXJ2   CBF(2)   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): ALPK2 promoter sequence
   Search SABiosciences Chromatin IP Primers for ALPK2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ALPK2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 18q21.31   Ensembl cytogenetic band:  18q21.32   HGNC cytogenetic band: 18q21.31

ALPK2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ALPK2 gene location

GeneLoc information about chromosome 18         GeneLoc Exon Structure

GeneLoc location for GC18M056148:  view genomic region     (about GC identifiers)

Start:
56,148,479 bp from pter      End:
56,296,189 bp from pter
Size:
147,711 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: ALPK2_HUMAN, Q86TB3 (See protein sequence)
Recommended Name: Alpha-protein kinase 2  
Size: 2170 amino acids; 237013 Da
Sequence caution: Sequence=AAK95952.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Sequence=AAK95952.1; Type=Miscellaneous discrepancy; Note=Aberrant splicing; Sequence=BAC03812.1; Type=Erroneous
initiation; Note=Translation N-terminally extended; Sequence=BAC03812.1; Type=Miscellaneous discrepancy;
Note=Aberrant splicing; Sequence=BX647796; Type=Miscellaneous discrepancy; Note=Aberrant splicing;
Sequence=CAD89922.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Secondary accessions: Q6ZUX0 Q8NAT5 Q96L95

Explore the universe of human proteins at neXtProt for ALPK2: NX_Q86TB3

Explore proteomics data for ALPK2 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q86TB3

  • ALPK2 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    ALPK2 Protein Expression
    REFSEQ proteins: NP_443179.3  
    ENSEMBL proteins: 
     ENSP00000354991  

    Human Recombinant Protein Products for ALPK2: 
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    Browse OriGene Protein Over-expression Lysates
    OriGene Custom MassSpec 
    OriGene Custom Protein Services for ALPK2
    GenScript Custom Purified and Recombinant Proteins Services for ALPK2
    Novus Biologicals ALPK2 Protein
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp. 


    ALPK2 Antibody Products: 
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    Novus Biologicals ALPK2 Antibodies
    Abcam antibodies for ALPK2
    Browse Antibodies at Cloud-Clone Corp. 
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    LSBio Antibodies in human, mouse, rat for ALPK2 

    Assay Products for ALPK2: 
    Browse Kits and Assays available from EMD Millipore
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    Browse ELISAs at Cloud-Clone Corp. 
    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    ISET: Immunoglobulin superfamily / I-set domain containing

    5/7 InterPro protein domains (see all 7):
     IPR003598 Ig_sub2
     IPR007110 Ig-like_dom
     IPR003599 Ig_sub
     IPR013098 Ig_I-set
     IPR011009 Kinase-like_dom

    Graphical View of Domain Structure for InterPro Entry Q86TB3

    ProtoNet protein and cluster: Q86TB3

    UniProtKB/Swiss-Prot: ALPK2_HUMAN, Q86TB3
    Similarity: Belongs to the protein kinase superfamily. Alpha-type protein kinase family. ALPK subfamily
    Similarity: Contains 1 alpha-type protein kinase domain
    Similarity: Contains 2 Ig-like (immunoglobulin-like) domains


    ALPK2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ALPK2_HUMAN, Q86TB3
    Function: Kinase that recognizes phosphorylation sites in which the surrounding peptides have an alpha-helical
    conformation

         Enzyme Number (IUBMB): EC 2.7.11.-1

         Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004674protein serine/threonine kinase activity IEA--
    GO:0005515protein binding ----
    GO:0005524ATP binding IEA--
    GO:0016772transferase activity, transferring phosphorus-containing groups ----
         
    ALPK2 for ontologies           About GeneDecksing


    Phenotypes:
         5 GenomeRNAi human phenotypes for ALPK2:
     Decreased focal adhesion (FA)   Decreased substrate adherent c  Gemcitabine induced cell-death  Increased apoptosis 
     Upregulation of Wnt/beta-caten 

         1 MGI phenotypic allele for Alpk2 (no phenotypes)

    ALPK2 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Alpk2tm1Lex for ALPK2

       inGenious Targeting Laboratory - Custom generated mouse model solutions for ALPK2 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for ALPK2

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for ALPK2 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for ALPK2 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ALPK2
    2 QIAGEN miScript miRNA Assays for microRNAs that regulate ALPK2:
    hsa-miR-19b hsa-miR-19a
    SwitchGear 3'UTR luciferase reporter plasmidALPK2 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for ALPK2
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ALPK2

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for ALPK2
    Sirion Biotech Customized adenovirus for overexpression of ALPK2

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for ALPK2 (see all 7)
    OriGene ORF clones in mouse, rat for ALPK2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: ALPK2 (NM_052947)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ALPK2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ALPK2

    Cell Line
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    GenScript Custom overexpressing Cell Line Services for ALPK2
    Search LifeMap BioReagents cell lines for ALPK2
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ALPK2


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ALPK2

    Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006468protein phosphorylation ----

    ALPK2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ALPK2

    Search CenterWatch for drugs/clinical trials and news about ALPK2

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for ALPK2 gene: 
    NM_052947.3  

    Unigene Cluster for ALPK2:

    Alpha-kinase 2
    Hs.628152  [show with all ESTs]
    Unigene Representative Sequence: BX647796
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000361673(uc002lhj.4 uc002lhk.1) ENST00000589204 ENST00000587842
    ENST00000587399 ENST00000590662 ENST00000590642
    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ALPK2
    2 QIAGEN miScript miRNA Assays for microRNAs that regulate ALPK2:
    hsa-miR-19b hsa-miR-19a
    SwitchGear 3'UTR luciferase reporter plasmidALPK2 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for ALPK2
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ALPK2
    Clone
    Products:
         
    OriGene clones in human, mouse for ALPK2 (see all 7)
    OriGene ORF clones in mouse, rat for ALPK2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: ALPK2 (NM_052947)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ALPK2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ALPK2
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for ALPK2
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat ALPK2
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ALPK2
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ALPK2

    Additional mRNA sequence: 

    AK092133.1 AK092194.1 AK125243.1 AL832018.2 AY044450.1 BX647446.1 BX647639.1 BX647796.1 

    6 DOTS entries:

    DT.91685353  DT.75160056  DT.101965645  DT.408049  DT.91981470  DT.95240125 

    24/59 AceView cDNA sequences (see all 59):

    BE551416 AI015219 BQ002209 AI796293 AA347019 AW732327 CN483959 BM674841 
    BE326314 AI014699 BX647796 AI433713 AX747371 BX951520 AL832018 AA345241 
    AI004225 BF431951 AK092194 BG752968 AY044450 BM717573 BP366142 AI636110 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ALPK2 expression in normal human tissues (normalized intensities)      ALPK2 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GTTGTGCTGT
    ALPK2 Expression
    About this image


    ALPK2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/21 selected tissues (see all 21) fully expand
     
     Fibroblast
             Detroit 551
             X-gene Foreskin Fibroblasts   
     
     Uncategorized (Uncategorized)    fully expand to see all 5 entries
             PureStem Progenitor E68
     
     Brain (Nervous System)    fully expand to see all 3 entries
             Human Cerebellar Astrocytes   
     
     Dermis (Uncategorized)    fully expand to see all 3 entries
             BH2 Dermal Fibroblasts   
     
     Mesenchymal Stem Cells
             Umbilical cord blood-derived mesenchymal stem cells
             Dental pulp Stem Cells (DPSC)   

    See ALPK2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ALPK2

    SOURCE GeneReport for Unigene cluster: Hs.628152
        SABiosciences Custom PCR Arrays for ALPK2
    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for ALPK2
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat ALPK2
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    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ALPK2
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ALPK2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for ALPK2 gene from 4/10 species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Alpk21 , 5 alpha-kinase 21, 5 71.24(n)1
    57.19(a)1
      18 (38.41 cM)5
    2256381  NM_001037294.11  NP_001032371.11 
     652655295 
    chicken
    (Gallus gallus)
    Aves ALPK26
    Uncharacterized protein
    75(a)
    1 ↔ 1
    Z(767645-796574)
    lizard
    (Anolis carolinensis)
    Reptilia ALPK26
    Uncharacterized protein
    61(a)
    1 ↔ 1
    GL343213.1(2703710-2780328)
    zebrafish
    (Danio rerio)
    Actinopterygii alpk26
    alpha-kinase 2
    22(a)
    1 ↔ 1
    21(9398951-9415884)


    ENSEMBL Gene Tree for ALPK2 (if available)
    TreeFam Gene Tree for ALPK2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ALPK2 gene
    ALPK32  

    ALPK2 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/3535 SNPs in ALPK2 are shown (see all 3535)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 18 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0455944
    A melanoma metastatic sample4--see VAR_0455942 K T mis40--------
    VAR_0455914
    An ovarian undifferentiated carcinoma sample4--see VAR_0455912 E K mis40--------
    rs2019387491,2
    Cuntested156204899(+) AGTTCC/TGTATC 2 T syn11Minor allele frequency- T:0.00EU 1313
    rs741832711,2
    C--52940822(+) TTTTG-/TTCC/ 
    TTCCTTCC
    TTCCT
    1 -- int11NA 2
    rs1410118061,2
    --56148061(+) CTTGCC/TCAATT 1 -- ds50010--------
    rs118732211,2
    C,F,H--56148216(+) CCCCCG/ACCAGG 1 -- ds50015Minor allele frequency- A:0.00NS EA NA 412
    rs45537071,2
    C,H--56148244(+) GGCCTG/ACATCT 1 -- ds500117Minor allele frequency- A:0.00NS EA WA NA CSA 789
    rs1450527981,2
    --56148254(+) TTCTGG/TCGCGA 1 -- ds50010--------
    rs747115731,2
    C,F--56148256(+) CTGGCG/ACGATC 1 -- ds50012Minor allele frequency- A:0.14CSA WA 119
    rs353382651,2
    C,F--56148331(+) CCTAAG/ATTGTA 1 -- ds50019Minor allele frequency- A:0.20NA WA CSA EA 369

    HapMap Linkage Disequilibrium report for ALPK2 (56148479 - 56296189 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for ALPK2:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2717161CNV Deletion23290073
    esv2442112CNV Insertion19546169
    nsv521388CNV Loss19592680
    nsv458089CNV Loss19166990
    nsv909667CNV Gain21882294

    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing ALPK2
    DNA2.0 Custom Variant and Variant Library Synthesis for ALPK2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    2 diseases for ALPK2:    About MalaCards
    multiple sclerosis    


    ALPK2 for disorders           About GeneDecksing

    Genetic Association Database (GAD): ALPK2
    Human Genome Epidemiology (HuGE) Navigator: ALPK2 (2 documents)

    Export disorders for ALPK2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ALPK2 gene integrated from 9 sources:
    (articles sorted by number of sources associating them with ALPK2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Alpha-kinases: a new class of protein kinases with a novel catalytic domain. (PubMed id 10021370)1, 2, 3 Ryazanov A.G.... Dorovkov M.V. (1999)
    2. Genetic analysis of diabetic nephropathy on chromosom e 18 in African Americans: linkage analysis and dense SNP mapping. (PubMed id 19690890)1, 4 McDonough C.W....Bowden D.W. (2009)
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    4. ALPK2 is crucial for luminal apoptosis and DNA repair- related gene expression in a three-dimensional colonic-crypt model. (PubMed id 22641666)1 Yoshida Y....Shirasawa S. (2012)
    5. Genetic risk and a primary role for cell-mediated immu ne mechanisms in multiple sclerosis. (PubMed id 21833088)1  ....Compston A. (2011)
    6. Global identification of modular cullin-RING ligase su bstrates. (PubMed id 21963094)1 Emanuele M.J....Elledge S.J. (2011)
    7. Patterns of somatic mutation in human cancer genomes. (PubMed id 17344846)2 Greenman C.... Stratton M.R. (2007)
    8. The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)2 Bechtel S.... Schupp I. (2007)
    9. DNA sequence and analysis of human chromosome 18. (PubMed id 16177791)2 Nusbaum C.... Lander E.S. (2005)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 115701 HGNC: 20565 AceView: HAK Ensembl:ENSG00000198796 euGenes: HUgn115701
    ECgene: ALPK2 H-InvDB: ALPK2

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ALPK2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for ALPK2 gene:
    Search GeneIP for patents involving ALPK2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
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     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for ALPK2  
     Browse OriGene qPCR primer pairs and template standards   Browse OriGene Protein Over-expression Lysates  
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     OriGene Custom Antibody Services for ALPK2   OriGene Custom Protein Services for ALPK2  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat ALPK2
     QIAGEN SeqTarget long-range PCR primers for resequencing ALPK2
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ALPK2
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ALPK2
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     GenScript Custom Purified and Recombinant Proteins Services for ALPK2 GenScript cDNA clones with any tag delivered in your preferred vector for ALPK2
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     Search for Antibodies & Assays

     Regulatory tfbs in ALPK2 promoter
     Search Chromatin IP Primers for ALPK2
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     Search GNC Networks for ALPK2
     SABiosciences Custom PCR Arrays for ALPK2
     Search Tocris compounds for ALPK2
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological Cell Lysates
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     Search Sino Biological for antibodies, proteins & pathways
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     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
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     See all of Abcam's Antibodies, Kits and Proteins for ALPK2
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     Browse ProSpec Recombinant Proteins




     Browse Proteins at Cloud-Clone Corp.
     Browse Antibodies at Cloud-Clone Corp.
     Browse ELISAs at Cloud-Clone Corp.
     Browse CLIAs at Cloud-Clone Corp.
     Search LifeMap BioReagents cell lines for ALPK2
     Gene Synthesis
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     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ALPK2
     SwitchGear 3'UTR luciferase reporter plasmids for ALPK2
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     Search ThermoFisher Antibodies for ALPK2
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ALPK2
     inGenious Targeting Laboratory - Custom generated mouse model solutions for ALPK2
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for ALPK2
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     LSBio Antibodies in human, mouse, rat for ALPK2
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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    (GIFtS: 73)
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