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Aliases for ALPK2 Gene

Aliases for ALPK2 Gene

  • Alpha-Kinase 2 2 3
  • Heart Alpha-Protein Kinase 3 4
  • Heart Alpha-Kinase 2 3
  • HAK 3 4
  • Alpha-Protein Kinase 2 3
  • EC 2.7.11.- 4

External Ids for ALPK2 Gene

Previous GeneCards Identifiers for ALPK2 Gene

  • GC18M054300
  • GC18M056148
  • GC18M052856

Summaries for ALPK2 Gene

GeneCards Summary for ALPK2 Gene

ALPK2 (Alpha-Kinase 2) is a Protein Coding gene. GO annotations related to this gene include protein serine/threonine kinase activity. An important paralog of this gene is ALPK3.

UniProtKB/Swiss-Prot for ALPK2 Gene

  • Kinase that recognizes phosphorylation sites in which the surrounding peptides have an alpha-helical conformation

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ALPK2 Gene

Genomics for ALPK2 Gene

Regulatory Elements for ALPK2 Gene

Genomic Location for ALPK2 Gene

Start:
58,481,247 bp from pter
End:
58,628,957 bp from pter
Size:
147,711 bases
Orientation:
Minus strand

Genomic View for ALPK2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ALPK2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ALPK2 Gene

Proteins for ALPK2 Gene

  • Protein details for ALPK2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q86TB3-ALPK2_HUMAN
    Recommended name:
    Alpha-protein kinase 2
    Protein Accession:
    Q86TB3
    Secondary Accessions:
    • Q6ZUX0
    • Q8NAT5
    • Q96L95

    Protein attributes for ALPK2 Gene

    Size:
    2170 amino acids
    Molecular mass:
    237013 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAK95952.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAK95952.1; Type=Miscellaneous discrepancy; Note=Aberrant splicing.; Evidence={ECO:0000305}; Sequence=BAC03812.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAC03812.1; Type=Miscellaneous discrepancy; Note=Aberrant splicing.; Evidence={ECO:0000305}; Sequence=BX647796; Type=Miscellaneous discrepancy; Note=Aberrant splicing.; Evidence={ECO:0000305}; Sequence=CAD89922.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

neXtProt entry for ALPK2 Gene

Proteomics data for ALPK2 Gene at MOPED

Post-translational modifications for ALPK2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ALPK2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ALPK2 Gene

Domains for ALPK2 Gene

Gene Families for ALPK2 Gene

HGNC:
  • ISET :Immunoglobulin superfamily / I-set domain containing

Protein Domains for ALPK2 Gene

Suggested Antigen Peptide Sequences for ALPK2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q86TB3

UniProtKB/Swiss-Prot:

ALPK2_HUMAN :
  • Q86TB3
Domain:
  • Contains 1 alpha-type protein kinase domain.
  • Contains 2 Ig-like (immunoglobulin-like) domains.
Family:
  • Belongs to the protein kinase superfamily. Alpha-type protein kinase family. ALPK subfamily.
genes like me logo Genes that share domains with ALPK2: view

Function for ALPK2 Gene

Molecular function for ALPK2 Gene

UniProtKB/Swiss-Prot Function: Kinase that recognizes phosphorylation sites in which the surrounding peptides have an alpha-helical conformation

Enzyme Numbers (IUBMB) for ALPK2 Gene

Gene Ontology (GO) - Molecular Function for ALPK2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004674 protein serine/threonine kinase activity IEA --
GO:0005515 protein binding --
GO:0005524 ATP binding IEA --
GO:0016772 transferase activity, transferring phosphorus-containing groups --
genes like me logo Genes that share ontologies with ALPK2: view
genes like me logo Genes that share phenotypes with ALPK2: view

Animal Model Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ALPK2

In Situ Assay Products

Flow Cytometry Products

No data available for Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for ALPK2 Gene

Localization for ALPK2 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ALPK2 Gene COMPARTMENTS Subcellular localization image for ALPK2 gene
Compartment Confidence
cytosol 2
nucleus 2

Gene Ontology (GO) - Cellular Components for ALPK2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus --
GO:0005654 nucleoplasm IDA --
genes like me logo Genes that share ontologies with ALPK2: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for ALPK2 Gene

Pathways for ALPK2 Gene

SuperPathways for ALPK2 Gene

No Data Available

Interacting Proteins for ALPK2 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000354991%0d%0a9606.ENSP00000344818%0d%0a
Selected Interacting proteins: ENSP00000354991 for ALPK2 Gene via STRING

Symbol External ID(s) Details
UBC

Gene Ontology (GO) - Biological Process for ALPK2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006468 protein phosphorylation IEA --
genes like me logo Genes that share ontologies with ALPK2: view

No data available for Pathways by source for ALPK2 Gene

Transcripts for ALPK2 Gene

Unigene Clusters for ALPK2 Gene

Alpha-kinase 2:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ALPK2

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for ALPK2

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ALPK2 Gene

No ASD Table

Relevant External Links for ALPK2 Gene

GeneLoc Exon Structure for
ALPK2
ECgene alternative splicing isoforms for
ALPK2

Expression for ALPK2 Gene

mRNA expression in normal human tissues for ALPK2 Gene

mRNA differential expression in normal tissues according to GTEx for ALPK2 Gene

This gene is overexpressed in Heart - Left Ventricle (14.3), Heart - Atrial Appendage (12.8), and Muscle - Skeletal (11.1).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for ALPK2 Gene

SOURCE GeneReport for Unigene cluster for ALPK2 Gene Hs.628152

genes like me logo Genes that share expressions with ALPK2: view

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for ALPK2 Gene

Orthologs for ALPK2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ALPK2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ALPK2 35
  • 96.7 (n)
  • 95.55 (a)
ALPK2 36
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ALPK2 35
  • 74.83 (n)
  • 60.63 (a)
ALPK2 36
  • 59 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ALPK2 35
  • 77.28 (n)
  • 63.83 (a)
ALPK2 36
  • 62 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Alpk2 35
  • 71.26 (n)
  • 57.24 (a)
Alpk2 16
Alpk2 36
  • 55 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ALPK2 36
  • 45 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ALPK2 36
  • 38 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Alpk2 35
  • 69.89 (n)
  • 55.59 (a)
chicken
(Gallus gallus)
Aves ALPK2 36
  • 75 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ALPK2 36
  • 59 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii alpk2 36
  • 27 (a)
OneToOne
Species with no ortholog for ALPK2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ALPK2 Gene

ENSEMBL:
Gene Tree for ALPK2 (if available)
TreeFam:
Gene Tree for ALPK2 (if available)

Paralogs for ALPK2 Gene

Paralogs for ALPK2 Gene

genes like me logo Genes that share paralogs with ALPK2: view

Variants for ALPK2 Gene

Sequence variations from dbSNP and Humsavar for ALPK2 Gene

SNP ID Clin Chr 18 pos Sequence Context AA Info Type MAF
rs10867 -- 58,481,594(-) GATTG(C/G)TCTCA utr-variant-3-prime
rs13016 -- 58,481,549(-) TTTTA(C/G)CAACC utr-variant-3-prime
rs1129928 -- 58,481,564(-) ATACA(C/T)GTTTA utr-variant-3-prime
rs1806503 -- 58,501,252(-) GCTTC(A/G)TGCAC intron-variant
rs1986700 -- 58,490,396(-) CAGGC(A/G)GAAAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ALPK2 Gene

Variant ID Type Subtype PubMed ID
nsv458089 CNV Loss 19166990
nsv909667 CNV Gain 21882294
nsv521388 CNV Loss 19592680
esv2442112 CNV Insertion 19546169
esv2717161 CNV Deletion 23290073

Relevant External Links for ALPK2 Gene

HapMap Linkage Disequilibrium report
ALPK2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ALPK2 Gene

Disorders for ALPK2 Gene

Relevant External Links for ALPK2

Genetic Association Database (GAD)
ALPK2
Human Genome Epidemiology (HuGE) Navigator
ALPK2
genes like me logo Genes that share disorders with ALPK2: view

No data available for UniProtKB/Swiss-Prot for ALPK2 Gene

Publications for ALPK2 Gene

  1. Alpha-kinases: a new class of protein kinases with a novel catalytic domain. (PMID: 10021370) Ryazanov A.G. … Dorovkov M.V. (Curr. Biol. 1999) 2 3 4
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. Genetic analysis of diabetic nephropathy on chromosome 18 in African Americans: linkage analysis and dense SNP mapping. (PMID: 19690890) McDonough C.W. … Bowden D.W. (Hum. Genet. 2009) 3 48
  4. Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis. (PMID: 21833088) . … Compston A. (Nature 2011) 3
  5. Global identification of modular cullin-RING ligase substrates. (PMID: 21963094) Emanuele M.J. … Elledge S.J. (Cell 2011) 3

Products for ALPK2 Gene

Sources for ALPK2 Gene

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