ALPK2 Gene
protein-coding GIFtS : 43
GCID: GC18 M056148
alpha-kinase 2
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Aliasesfor ALPK2 gene
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc ,
7 Ensembl ,
8 DME ,
9 miRBase ,
and/or 10 fRNAdb )About This Section Aliases Alpha-Kinase 2 1 2 HAK1 2 3 Heart Alpha-Protein Kinase2 3 Alpha-Protein Kinase 22 Heart Alpha-Kinase2 EC 2.7.11.-3
Export aliases for ALPK2 gene to outside databases Previous GC identifers: GC18M054300 GC18M052856
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Summariesfor ALPK2 gene (According to Entrez Gene ,
Tocris Bioscience ,
Wikipedia's
Gene Wiki ,
PharmGKB ,
UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
About This Section UniProtKB/Swiss-Prot: ALPK2_HUMAN, Q86TB3 Function : Kinase that recognizes phosphorylation sites in which the surrounding peptides have an alpha-helicalconformation
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Genomic Viewsfor ALPK2 gene
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 37) ,
and/or miRBase ,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69) ,
Regulatory elements and Epigenetics data according to
QIAGEN ,
SABiosciences , and/or
SwitchGear Genomics )About This Section RefSeq DNA sequence: NC_000018.9 NC_018929.1 NT_025028.14 Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the ALPK2 gene promoter: CBF-C PPAR-gamma1 CBF-B CBF-A HOXA5 FOXJ2 (long isoform) CP1A PPAR-gamma2 FOXJ2 CBF(2) Other transcription factors Search SABiosciences Chromatin IP Primers for ALPK2 Epigenetics: QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ALPK2
Genomic Location: Genomic View : UCSC Golden Path with GeneCards custom track Entrez Gene cytogenetic band: 18q21.31 Ensembl cytogenetic band: 18q21.32 HGNC cytogenetic band: 18q21.31 ALPK2 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different) GeneLoc information about chromosome 18 GeneLoc Exon Structure
GeneLoc location for GC18M056148: view genomic region
(about GC identifiers )
Start:
56,148,479 bp from pter
End:
56,296,189 bp from pter
Size:
147,711 bases
Orientation:
minus strand
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Proteinsfor ALPK2 gene
(According to
1 UniProtKB ,
HORDE ,
neXtProt ,
Ensembl ,
and/or Reactome ,
Modification sites according to 2 PhosphoSitePlus ,
Specific Peptides from DME ,
Protein expression images according to data from SPIRE MOPED and PaxDb ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from
EMD Millipore ,
R&D Systems ,
GenScript ,
Enzo Life Sciences ,
OriGene ,
Novus Biologicals ,
Sino Biological ,
ProSpec , and/or
Uscn ,
Biochemical Assays by
EMD Millipore ,
R&D Systems ,
OriGene ,
GenScript ,
Cell Signaling Technology ,
Enzo Life Sciences , and/or
Uscn ,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene ,
Antibodies by
EMD Millipore ,
R&D Systems ,
GenScript ,
Cell Signaling Technology ,
OriGene ,
Novus Biologicals ,
Thermo Fisher Scientific ,
Abcam , and/or
Uscn )
About This Section UniProtKB/Swiss-Prot: ALPK2_HUMAN, Q86TB3 (See
protein sequence )Recommended Name: Alpha-protein kinase 2 Size : 2170 amino acids; 237013 Da
Sequence caution : Sequence=AAK95952.1; Type=Erroneous initiation; Note=Translation N-terminally extended;Sequence=AAK95952.1; Type=Miscellaneous discrepancy; Note=Aberrant splicing; Sequence=BAC03812.1; Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=BAC03812.1; Type=Miscellaneous discrepancy; Note=Aberrant splicing; Sequence=BX647796; Type=Miscellaneous discrepancy; Note=Aberrant splicing; Sequence=CAD89922.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Secondary accessions : Q6ZUX0 Q8NAT5 Q96L95Explore the universe of human proteins at neXtProt for ALPK2: NX_Q86TB3 Post-translational modifications:
View modification sites using PhosphoSitePlus 2 View neXtProt modification sites for NX_Q86TB3 ALPK2 Protein expression data from MOPED and PaxDb : About this image REFSEQ proteins: NP_443179.3 ENSEMBL proteins: ENSP00000354991 Human Recombinant Protein Products for ALPK2: ALPK2 Antibody Products: Assay Products for ALPK2:
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Protein
Domains / Familiesfor ALPK2 gene (According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
About This Section
ALPK2 for domains About GeneDecksing 5/7 InterPro domains/families (see all 7 ):
Graphical View of Domain Structure for InterPro Entry Q86TB3 ProtoNet protein and cluster: Q86TB3
UniProtKB/Swiss-Prot: ALPK2_HUMAN, Q86TB3 Similarity : Belongs to the protein kinase superfamily. Alpha-type protein kinase family. ALPK subfamilySimilarity : Contains 1 alpha-type protein kinase domainSimilarity : Contains 2 Ig-like (immunoglobulin-like) domains
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Functionfor ALPK2 gene
(According to 1 UniProtKB ,
Genatlas ,
LifeMap Discovery™ ,
IUBMB , and/or
2 DME ,
Human phenotypes from GenomeRNAi ,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory ,
bound targets from SABiosciences ,
miRNA Gene Targets from miRTarBase ,
shRNA from
OriGene ,
Sirion Biotech ,
RNAi from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
microRNA from QIAGEN ,
Gene Editing from DNA2.0 ,
Sirion Biotech ,
Clones from EMD Millipore ,
OriGene ,
SwitchGear Genomics ,
GenScript ,
Sino Biological ,
DNA2.0 ,
and Vector BioLabs ,
Cell Lines from GenScript ,
LifeMap BioReagents ,
Sirion Biotech ,
In Situ Hybridization Assays from Advanced Cell Diagnostics ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene .)
About This Section Molecular Function: UniProtKB/Swiss-Prot Summary: ALPK2_HUMAN, Q86TB3 Function : Kinase that recognizes phosphorylation sites in which the surrounding peptides have an alpha-helicalconformation Enzyme Number (IUBMB): EC 2.7.11.- 1
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view) : About this table
GO ID Qualified GO term Evidence PubMed IDs GO:0004674 protein serine/threonine kinase activity
IEA -- GO:0005524 ATP binding
IEA --
ALPK2 for ontologies About GeneDecksing Phenotypes: 5 GenomeRNAi human phenotypes for ALPK2 : 1 MGI phenotypic allele for Alpk2 (no phenotypes)
ALPK2 for phenotypes About GeneDecksing Animal Models: Mouse knock-out Alpk2 tm1Lex for ALPK2Clone Products: Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for ALPK2 (see all 2 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for ALPK2 (see all 3 )OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector: ALPK2 (NM_052947 ) Browse Sino Biological Human cDNA Clones DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ALPK2 Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat ALPK2
In Situ Assay Products: Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ALPK2
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Pathways & Interactionsfor ALPK2 gene
(Pathways according to
EMD Millipore ,
R&D Systems ,
Cell Signaling Technology ,
KEGG ,
PharmGKB ,
BioSystems ,
Reactome ,
Tocris Bioscience ,
GeneGo (Thomson Reuters) ,
QIAGEN ,
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Interaction Networks according to
SABiosciences ,
and/or STRING ,
Interactions according to 1 UniProtKB ,
2 MINT ,
3 I2D , and/or
4 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene) .
About This Section Interactions: Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ALPK2
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Drugs & Compoundsfor ALPK2 gene (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
EMD Millipore , Tocris Bioscience
HMDB ,
BitterDB , and/or
Novoseek , and Drugs according to
DrugBank ,
Enzo Life Sciences , and/or
PharmGKB , with drugs/clinical trials/news
search links to CenterWatch )
About This Section Browse Tocris compounds for ALPK2 Search CenterWatch for drugs/clinical trials and news about ALPK2
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Transcriptsfor ALPK2 gene (Secondary structures according to
fRNAdb ,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank , RefSeq according to Entrez Gene ,
DOTS (version 10), and/or
AceView ,
transcript ids from Ensembl
with links to UCSC ,
exon structure from GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,
RNAi Products from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
shRNA from
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Sirion Biotech ,
microRNA from QIAGEN ,
Tagged/untagged cDNA clones from
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SwitchGear Genomics ,
GenScript ,
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Primers from
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SABiosciences , and/or
QIAGEN
)About This Section REFSEQ mRNAs for ALPK2 gene: NM_052947.3 Unigene Cluster for ALPK2:
Alpha-kinase 2 Hs.628152 [show with all ESTs ] Unigene Representative Sequence: BX647796 6 Ensembl transcripts including schematic representations, and UCSC links where relevant : ENST00000361673 (uc002lhj.4 uc002lhk.1 ) ENST00000589204 ENST00000587842 ENST00000587399 ENST00000590662 ENST00000590642 Clone Products: OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for ALPK2 (see all 2 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for ALPK2 (see all 3 )OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector: ALPK2 (NM_052947 ) DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ALPK2 Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat ALPK2
Additional cDNA sequence: AK092133.1 AK092194.1 AK125243.1 AL832018.2 AY044450.1 BX647446.1 BX647639.1 BX647796.1
6 DOTS entries : DT.91685353 DT.75160056
DT.101965645 DT.408049 DT.91981470 DT.95240125 24/59 AceView cDNA sequences (see all 59 ):
AW732327 CN483959 BE551416 AA347019 AI796293 AI015219 BQ002209 AI014699 AL832018 BG752968 AK092133 BM674841 AA889330 AX747403 AK125243 AI284220 BX647796 AA262326 AI949720 AI433713 BE465215 AI636110 BX951520 AK092194 GeneLoc Exon Structure
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Expression for ALPK2 gene
(RNA expression data according to
H-InvDB ,
NONCODE ,
miRBase , and
RNAdb ,
Expression images according to data from
BioGPS ,
Illumina Human BodyMap , and
CGAP
SAGE ,
Sets of similar genes according to GeneDecks ,
in vivo and in vitro expression data from LifeMap Discovery™ ,
plus additional links to
Genevestigator , and/or
SOURCE , and/or
BioGPS , and/or
UniProtKB ,
PCR Arrays from
SABiosciences ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN ,
In Situ Hybridization Assays from Advanced Cell Diagnostics )
About This Section ALPK2 expression in normal human tissues (normalized intensities) See probesets specificity/sensitivity at GeneAnnot About this image BioGPS CGAP TAG: GTTGTGCTGTAbout this image ALPK2 expression in embryonic tissues and stem cells Expression by the Database of Embryonic development, Stem cell research, and
Regenerative medicine About this table
See ALPK2 Protein Expression from SPIRE MOPED and PaxDB Genevestigator expression for ALPK2 SOURCE GeneReport for Unigene cluster: Hs.628152 SABiosciences Custom PCR Arrays for ALPK2 Primer Products: OriGene genome-wide validated SYBR primer pairs in human , mouse , rat for ALPK2Browse OriGene validated miRNA SYBR primer pairs SABiosciences RT2 qPCR Primer Assay in human , mouse , rat ALPK2 QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat ALPK2 QIAGEN QuantiFast Probe-based Assays in human , mouse , rat ALPK2 In Situ Assay Products: Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ALPK2
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Orthologsfor ALPK2 gene
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
,
5 MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase ,
and/or
6 Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam )
About This Section
This gene was present in the common ancestor of chordates.
Orthologs for ALPK2 gene from 3/10 species (see all 10 ) About this table
Organism
Taxonomic classification
Gene
Description
Human Similarity
Orthology Type
Details
chicken (Gallus gallus)
Aves
ALPK26
Uncharacterized protein
75(a)
1 ↔ 1
Z(656540-670235)
lizard (Anolis carolinensis)
Reptilia
ALPK26
--
66(a)
1 ↔ 1
GL343213.1(2705339-2733824)
zebrafish (Danio rerio)
Actinopterygii
alpk26
alpha-kinase 2
19(a)
1 ↔ 1
21(9398951-9415884)
ENSEMBL Gene Tree for ALPK2 (if available)TreeFam Gene Tree for ALPK2 (if available)
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Paralogsfor ALPK2 gene (Paralogs according to
1 HomoloGene , 2 Ensembl , and 3 SIMAP , Pseudogenes according to 4 Pseudogene.org Build 68)About This Section Paralogs for ALPK2 gene ALPK3 2
ALPK2 for paralogs About GeneDecksing
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Genomic Variantsfor ALPK2 gene (SNPs/Variants according to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE ,
UniProtKB , and
DNA2.0 ,
Linkage Disequilibrium by HapMap ,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants , Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB) , Blood group antigen gene mutations by BGMUT ,
Resequencing Primers from QIAGEN ,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences )
About This Section
Genomic Data Transcription Related Data Allele Frequencies SNP ID Valid Clinical significance Chr 18 pos Sequence # AA Chg Type More # Allele freq Pop Total sample More
HapMap Linkage Disequilibrium report for ALPK2 (56148479 - 56296189 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions) Database of Genomic Variants (DGV): 6 variations for ALPK2 6 Indels : 77902 77904 88872 77903 102682 88873
SABiosciences Cancer Mutation PCR Assays
QIAGEN SeqTarget long-range PCR primers in human , mouse , rat for resequencing ALPK2
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Disorders
/ Diseasesfor ALPK2 gene
(in which this Gene is Involved, According to MalaCards ,
OMIM, UniProtKB ,
the University of Copenhagen DISEASES
database ,
Genatlas , GeneTests ,
GAD ,
HuGE Navigator ,
and/or TGDB .)
About This Section
ALPK2 for disorders About GeneDecksing 1 disease for ALPK2 : About MalaCards nephropathy Human Genome Epidemiology (HuGE) Navigator: ALPK2 (2 documents) Export disorders for ALPK2 gene to outside databases
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Publicationsfor ALPK2 gene (in
PubMed .
Associations of this gene to articles via
1 Entrez Gene ,
2 UniProtKB/Swiss-Prot ,
3 HGNC ,
4 GAD ,
5 PharmGKB ,
6 HMDB ,
7 DrugBank ,
8 UniProtKB/TrEMBL ,
9 Novoseek , and/or
10 fRNAdb )
About This Section PubMed articles for ALPK2 gene integrated from 9 sources : (articles sorted by number of sources associating them with ALPK2) Utopia : connect your pdf to the dynamic world of online information
Alpha-kinases: a new class of protein kinases with a novel catalytic domain. (PubMed id 10021370) 1 , 2 , 3 Ryazanov A.G.... Dorovkov M.V. (1999) Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039) 1 , 2 Ota T.... Sugano S. (2004) ALPK2 is crucial for luminal apoptosis and DNA repair- related gene expression in a three-dimensional colonic-crypt model. (PubMed id 22641666) 1 Yoshida Y....Shirasawa S. (2012) Genetic risk and a primary role for cell-mediated immu ne mechanisms in multiple sclerosis. (PubMed id 21833088) 1 ....Compston A. (2011) Genetic analysis of diabetic nephropathy on chromosom e 18 in African Americans: linkage analysis and dense SNP mapping. (PubMed id 19690890) 1 McDonough C.W....Bowden D.W. (2009) Patterns of somatic mutation in human cancer genomes. (PubMed id 17344846) 2 Greenman C.... Stratton M.R. (2007) The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005) 2 Bechtel S.... Schupp I. (2007) DNA sequence and analysis of human chromosome 18. (PubMed id 16177791) 2 Nusbaum C.... Lander E.S. (2005)
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External Searches for ALPK2 gene
(in PubMed ,
OMIM , and NCBI Bookshelf ) About This Section
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Genome Databases showing ALPK2 gene
(According to
Entrez Gene ,
HGNC ,
AceView ,
euGenes ,
Ensembl ,
miRBase ,
ECgene ,
Kegg ,
and/or
H-InvDB )
About This Section
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Other Databases showing ALPK2 gene
(According to HUGE )
About This Section --
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Specialized Databases showing ALPK2 gene (According to PharmGKB ,
ATLAS , HORDE , IMGT , LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
Name Description
PharmGKB entry for ALPK2 Pharmacogenomics, SNPs, Pathways
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About This Section Patent Information for ALPK2 gene: Search GeneIP for patents involving ALPK2 GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Productsfor ALPK2 gene (Antibodies, recombinant proteins, and assays from EMD Millipore , R&D Systems , OriGene , QIAGEN , GenScript , Cell Signaling Technology , SABiosciences , Novus Biologicals , Sino Biological , Enzo Life Sciences , Abcam , ProSpec , Uscn , Thermo Fisher Scientific , Gene Editing from DNA2.0 and Sirion Biotech , Clones from EMD Millipore , OriGene , GenScript , Sino Biological , DNA2.0 , SwitchGear Genomics , Vector BioLabs , Cell lines from GenScript , LifeMap BioReagents , and Sirion Biotech , PCR Arrays from SABiosciences , Drugs and/or compounds from EMD Millipore , Tocris Bioscience , and/or
Enzo Life Sciences , In Situ Hybridization Assays from Advanced Cell Diagnostics , Animal models from inGenious Targeting Laboratory )About This Section
Browse OriGene Antibodies OriGene shRNA RFP for ALPK2 OriGene 29mer shRNA kits in GFP-retroviral vector in human , mouse , rat for ALPK2 OriGene genome-wide validated SYBR primer pairs in human , mouse , rat for ALPK2 Browse OriGene Protein Over-expression Lysates Browse OriGene Fluorogenic Cell Assay Kits OriGene siRNA for ALPK2 OriGene 3'-UTR Clone for ALPK2 OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for ALPK2 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for ALPK2 Browse OriGene GFP tagged cDNA clones in CMV expression vector Browse OriGene MicroRNA Expression Plasmids Browse OriGene basic RS shRNAs Browse OriGene validated miRNA SYBR primer pairs Browse OriGene full length recombinant human proteins expressed in human HEK293 cells OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling OriGene Custom Antibody Services for ALPK2 OriGene Custom Protein Services for ALPK2 OriGene Custom Immunoassay Development
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat ALPK2 QIAGEN SeqTarget long-range PCR primers in human , mouse , rat for resequencing ALPK2 QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ALPK2 QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human , mouse , rat ALPK2 QIAGEN QuantiFast Probe-based Assays in human , mouse , rat ALPK2 QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat ALPK2
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ALPK2 Proteins, Antibodies, CLIAs, and ELISAs
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ALPK2
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Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat ALPK2
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