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Aliases for ALPK1 Gene

Aliases for ALPK1 Gene

  • Alpha Kinase 1 2 3 5
  • Lymphocyte Alpha-Protein Kinase 3 4
  • Lymphocyte Alpha-Kinase 2 3
  • Chromosome 4 Kinase 3 4
  • LAK 3 4
  • Alpha-Protein Kinase 1 3
  • 8430410J10Rik 3
  • EC 2.7.11.- 4
  • KIAA1527 4

External Ids for ALPK1 Gene

Previous GeneCards Identifiers for ALPK1 Gene

  • GC04P113657
  • GC04P113438
  • GC04P113218
  • GC04P108950

Summaries for ALPK1 Gene

Entrez Gene Summary for ALPK1 Gene

  • This gene encodes an alpha kinase. Mice which were homozygous for disrupted copies of this gene exhibited coordination defects (PMID: 21208416). Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011]

GeneCards Summary for ALPK1 Gene

ALPK1 (Alpha Kinase 1) is a Protein Coding gene. GO annotations related to this gene include transferase activity, transferring phosphorus-containing groups and kinase activity. An important paralog of this gene is EEF2K.

UniProtKB/Swiss-Prot for ALPK1 Gene

  • Kinase that recognizes phosphorylation sites in which the surrounding peptides have an alpha-helical conformation.

Gene Wiki entry for ALPK1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ALPK1 Gene

Genomics for ALPK1 Gene

Regulatory Elements for ALPK1 Gene

Enhancers for ALPK1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH04F112312 1.6 FANTOM5 Ensembl ENCODE 4 +27.4 27356 1.9 HDGF TBP PKNOX1 POLR2A GATA2 CBX5 NCOR1 EED ETV6 MTA2 TIFA AP1AR ALPK1 LARP7 GC04P112321
GH04F112282 1 FANTOM5 ENCODE 2.4 +0.8 845 7.6 HDGF PKNOX1 WRNIP1 ARID4B SIN3A GLI4 DMAP1 ZNF2 YY1 GLIS2 TIFA C4orf32 AP1AR RTEL1P1 LARP7 ALPK1 ZGRF1 GC04P112321
GH04F112279 1.3 FANTOM5 Ensembl ENCODE 0.4 -5.4 -5409 2.2 PKNOX1 TBL1XR1 BMI1 CREM JUNB CEBPB TBX21 IKZF1 CEBPA NBN TIFA C4orf32 ALPK1 ENSG00000272567
GH04F112276 0.5 ENCODE 0.4 -7.8 -7845 2.0 PKNOX1 GATA3 CTBP1 NBN TBX21 SPI1 TIFA C4orf32 ENSG00000272567 ALPK1
GH04F112272 0.2 ENCODE 0.4 -11.9 -11856 1.6 JUNB JUND IKZF1 TARDBP NBN FOS ETV6 MLLT1 TIFA C4orf32 ENSG00000272567 ALPK1
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around ALPK1 on UCSC Golden Path with GeneCards custom track

Promoters for ALPK1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001247536 -509 3201 HDGF WRNIP1 ARID4B SIN3A GLI4 DMAP1 ZNF2 YY1 GLIS2 ZNF143

Genomic Location for ALPK1 Gene

Chromosome:
4
Start:
112,285,509 bp from pter
End:
112,442,620 bp from pter
Size:
157,112 bases
Orientation:
Plus strand

Genomic View for ALPK1 Gene

Genes around ALPK1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ALPK1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ALPK1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ALPK1 Gene

Proteins for ALPK1 Gene

  • Protein details for ALPK1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96QP1-ALPK1_HUMAN
    Recommended name:
    Alpha-protein kinase 1
    Protein Accession:
    Q96QP1
    Secondary Accessions:
    • B4E3G1
    • F5H138
    • Q68CI9
    • Q6P9F9
    • Q6ZNK4
    • Q9P201

    Protein attributes for ALPK1 Gene

    Size:
    1244 amino acids
    Molecular mass:
    138861 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAC85140.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAC85140.1; Type=Frameshift; Positions=208, 1022; Evidence={ECO:0000305}; Sequence=BAC85140.1; Type=Miscellaneous discrepancy; Note=Intron retention.; Evidence={ECO:0000305}; Sequence=BC060780; Type=Frameshift; Positions=1044; Evidence={ECO:0000305};

    Alternative splice isoforms for ALPK1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ALPK1 Gene

Post-translational modifications for ALPK1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ALPK1 Gene

Domains & Families for ALPK1 Gene

Gene Families for ALPK1 Gene

IUPHAR :

Protein Domains for ALPK1 Gene

Graphical View of Domain Structure for InterPro Entry

Q96QP1

UniProtKB/Swiss-Prot:

ALPK1_HUMAN :
  • Contains 1 alpha-type protein kinase domain.
  • Belongs to the protein kinase superfamily. Alpha-type protein kinase family. ALPK subfamily.
Domain:
  • Contains 1 alpha-type protein kinase domain.
Family:
  • Belongs to the protein kinase superfamily. Alpha-type protein kinase family. ALPK subfamily.
genes like me logo Genes that share domains with ALPK1: view

Function for ALPK1 Gene

Molecular function for ALPK1 Gene

UniProtKB/Swiss-Prot Function:
Kinase that recognizes phosphorylation sites in which the surrounding peptides have an alpha-helical conformation.

Enzyme Numbers (IUBMB) for ALPK1 Gene

Gene Ontology (GO) - Molecular Function for ALPK1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004674 protein serine/threonine kinase activity IBA --
GO:0005524 ATP binding IEA --
GO:0016301 kinase activity IEA --
GO:0016740 transferase activity IEA --
genes like me logo Genes that share ontologies with ALPK1: view
genes like me logo Genes that share phenotypes with ALPK1: view

Animal Model Products

  • Taconic Biosciences Mouse Models for ALPK1

Inhibitory RNA Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for ALPK1 Gene

Localization for ALPK1 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ALPK1 Gene COMPARTMENTS Subcellular localization image for ALPK1 gene
Compartment Confidence
cytoskeleton 2
cytosol 1
endoplasmic reticulum 1
mitochondrion 1
nucleus 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for ALPK1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IBA --
genes like me logo Genes that share ontologies with ALPK1: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for ALPK1 Gene

Pathways & Interactions for ALPK1 Gene

SuperPathways for ALPK1 Gene

No Data Available

Interacting Proteins for ALPK1 Gene

Gene Ontology (GO) - Biological Process for ALPK1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006468 protein phosphorylation IEA --
GO:0016310 phosphorylation IEA --
genes like me logo Genes that share ontologies with ALPK1: view

No data available for Pathways by source and SIGNOR curated interactions for ALPK1 Gene

Transcripts for ALPK1 Gene

Unigene Clusters for ALPK1 Gene

Alpha-kinase 1:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ALPK1 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6 ^ 7a · 7b ^ 8 ^ 9a · 9b ^ 10 ^ 11a · 11b ^ 12a · 12b ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18a ·
SP1: - - - - - - - -
SP2: - - - - - - - - -
SP3: - - -
SP4:
SP5:
SP6: - -
SP7:
SP8: -

ExUns: 18b
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:

Relevant External Links for ALPK1 Gene

GeneLoc Exon Structure for
ALPK1
ECgene alternative splicing isoforms for
ALPK1

Expression for ALPK1 Gene

mRNA expression in normal human tissues for ALPK1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ALPK1 Gene

This gene is overexpressed in Whole Blood (x10.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ALPK1 Gene



Protein tissue co-expression partners for ALPK1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ALPK1 Gene:

ALPK1

SOURCE GeneReport for Unigene cluster for ALPK1 Gene:

Hs.652825

mRNA Expression by UniProt/SwissProt for ALPK1 Gene:

Q96QP1-ALPK1_HUMAN
Tissue specificity: Highly expressed in liver.
genes like me logo Genes that share expression patterns with ALPK1: view

Primer Products

No data available for Protein differential expression in normal tissues for ALPK1 Gene

Orthologs for ALPK1 Gene

This gene was present in the common ancestor of animals.

Orthologs for ALPK1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ALPK1 34 35
  • 99.28 (n)
dog
(Canis familiaris)
Mammalia ALPK1 34 35
  • 85.24 (n)
cow
(Bos Taurus)
Mammalia ALPK1 34 35
  • 83.44 (n)
mouse
(Mus musculus)
Mammalia Alpk1 34 16 35
  • 77.73 (n)
rat
(Rattus norvegicus)
Mammalia Alpk1 34
  • 77.04 (n)
oppossum
(Monodelphis domestica)
Mammalia ALPK1 35
  • 61 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ALPK1 35
  • 59 (a)
OneToOne
chicken
(Gallus gallus)
Aves ALPK1 34 35
  • 62.42 (n)
lizard
(Anolis carolinensis)
Reptilia ALPK1 35
  • 53 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia alpk1 34
  • 60.05 (n)
zebrafish
(Danio rerio)
Actinopterygii ALPK1 35
  • 27 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea efk-1 35
  • 10 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.7709 35
  • 14 (a)
ManyToMany
-- 35
  • 11 (a)
ManyToMany
Species where no ortholog for ALPK1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ALPK1 Gene

ENSEMBL:
Gene Tree for ALPK1 (if available)
TreeFam:
Gene Tree for ALPK1 (if available)

Paralogs for ALPK1 Gene

Paralogs for ALPK1 Gene

genes like me logo Genes that share paralogs with ALPK1: view

Variants for ALPK1 Gene

Sequence variations from dbSNP and Humsavar for ALPK1 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type
VAR_041514 An ovarian mucinous carcinoma sample
rs10000890 -- 112,300,813(+) AGTAA(G/T)TTATA intron-variant, upstream-variant-2KB
rs10002070 -- 112,358,310(+) ATGTC(A/G)TCCAA intron-variant
rs10003166 -- 112,346,013(+) cgtgc(A/G)ctgcc intron-variant
rs10007654 -- 112,372,556(+) tatat(A/C)tttat intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ALPK1 Gene

Variant ID Type Subtype PubMed ID
esv2152267 CNV deletion 18987734
esv2666363 CNV deletion 23128226
esv26687 CNV loss 19812545
esv2728152 CNV deletion 23290073
esv2728153 CNV deletion 23290073
esv3369923 CNV duplication 20981092
esv3569663 CNV loss 25503493
esv3601799 CNV loss 21293372
esv994179 CNV deletion 20482838
nsv1128089 CNV deletion 24896259
nsv291215 CNV deletion 16902084
nsv4470 CNV insertion 18451855

Variation tolerance for ALPK1 Gene

Residual Variation Intolerance Score: 95.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.14; 75.67% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ALPK1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ALPK1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ALPK1 Gene

Disorders for ALPK1 Gene

Relevant External Links for ALPK1

Genetic Association Database (GAD)
ALPK1
Human Genome Epidemiology (HuGE) Navigator
ALPK1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ALPK1

No disorders were found for ALPK1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ALPK1 Gene

Publications for ALPK1 Gene

  1. Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10819331) Nagase T. … Ohara O. (DNA Res. 2000) 2 3 4 64
  2. Alpha-kinases: a new class of protein kinases with a novel catalytic domain. (PMID: 10021370) Ryazanov A.G. … Dorovkov M.V. (Curr. Biol. 1999) 2 3 4 64
  3. A genome-wide association meta-analysis identifies new childhood obesity loci. (PMID: 22484627) Bradfield J.P. … Grant S.F. (Nat. Genet. 2012) 3 46 64
  4. Genome-wide association study of epirubicin-induced leukopenia in Japanese patients. (PMID: 21799462) Srinivasan Y. … Zembutsu H. (Pharmacogenet. Genomics 2011) 3 46 64
  5. A systematic gene-based screen of chr4q22-q32 identifies association of a novel susceptibility gene, DKK2, with the quantitative trait of alcohol dependence symptom counts. (PMID: 20332099) Kalsi G. … Riley B.P. (Hum. Mol. Genet. 2010) 3 46 64

Products for ALPK1 Gene

Sources for ALPK1 Gene

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