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Aliases for ALPK1 Gene

Aliases for ALPK1 Gene

  • Alpha Kinase 1 2 3 5
  • Lymphocyte Alpha-Protein Kinase 3 4
  • Lymphocyte Alpha-Kinase 2 3
  • Chromosome 4 Kinase 3 4
  • LAK 3 4
  • Alpha-Kinase 1 3
  • 8430410J10Rik 3
  • EC 2.7.11.- 4
  • KIAA1527 4

External Ids for ALPK1 Gene

Previous GeneCards Identifiers for ALPK1 Gene

  • GC04P113657
  • GC04P113438
  • GC04P113218
  • GC04P108950

Summaries for ALPK1 Gene

Entrez Gene Summary for ALPK1 Gene

  • This gene encodes an alpha kinase. Mice which were homozygous for disrupted copies of this gene exhibited coordination defects (PMID: 21208416). Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011]

GeneCards Summary for ALPK1 Gene

ALPK1 (Alpha Kinase 1) is a Protein Coding gene. GO annotations related to this gene include transferase activity, transferring phosphorus-containing groups and kinase activity. An important paralog of this gene is EEF2K.

UniProtKB/Swiss-Prot for ALPK1 Gene

  • Kinase that recognizes phosphorylation sites in which the surrounding peptides have an alpha-helical conformation.

Gene Wiki entry for ALPK1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ALPK1 Gene

Genomics for ALPK1 Gene

Regulatory Elements for ALPK1 Gene

Enhancers for ALPK1 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around ALPK1 on UCSC Golden Path with GeneCards custom track

Genomic Location for ALPK1 Gene

112,285,509 bp from pter
112,442,620 bp from pter
157,112 bases
Plus strand

Genomic View for ALPK1 Gene

Genes around ALPK1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ALPK1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ALPK1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ALPK1 Gene

Proteins for ALPK1 Gene

  • Protein details for ALPK1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Alpha-protein kinase 1
    Protein Accession:
    Secondary Accessions:
    • B4E3G1
    • F5H138
    • Q68CI9
    • Q6P9F9
    • Q6ZNK4
    • Q9P201

    Protein attributes for ALPK1 Gene

    1244 amino acids
    Molecular mass:
    138861 Da
    Quaternary structure:
    No Data Available
    • Sequence=BAC85140.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAC85140.1; Type=Frameshift; Positions=208, 1022; Evidence={ECO:0000305}; Sequence=BAC85140.1; Type=Miscellaneous discrepancy; Note=Intron retention.; Evidence={ECO:0000305}; Sequence=BC060780; Type=Frameshift; Positions=1044; Evidence={ECO:0000305};

    Alternative splice isoforms for ALPK1 Gene


neXtProt entry for ALPK1 Gene

Proteomics data for ALPK1 Gene at MOPED

Post-translational modifications for ALPK1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ALPK1 Gene

Domains & Families for ALPK1 Gene

Gene Families for ALPK1 Gene


Protein Domains for ALPK1 Gene


Graphical View of Domain Structure for InterPro Entry



  • Contains 1 alpha-type protein kinase domain.
  • Belongs to the protein kinase superfamily. Alpha-type protein kinase family. ALPK subfamily.
  • Contains 1 alpha-type protein kinase domain.
  • Belongs to the protein kinase superfamily. Alpha-type protein kinase family. ALPK subfamily.
genes like me logo Genes that share domains with ALPK1: view

Function for ALPK1 Gene

Molecular function for ALPK1 Gene

UniProtKB/Swiss-Prot Function:
Kinase that recognizes phosphorylation sites in which the surrounding peptides have an alpha-helical conformation.

Enzyme Numbers (IUBMB) for ALPK1 Gene

genes like me logo Genes that share phenotypes with ALPK1: view

Animal Model Products

  • Taconic Biosciences Mouse Models for ALPK1

No data available for Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for ALPK1 Gene

Localization for ALPK1 Gene

Subcellular locations from

Jensen Localization Image for ALPK1 Gene COMPARTMENTS Subcellular localization image for ALPK1 gene
Compartment Confidence
cytoskeleton 2
cytosol 1
endoplasmic reticulum 1
mitochondrion 1
nucleus 1
peroxisome 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for ALPK1 Gene

Pathways & Interactions for ALPK1 Gene

SuperPathways for ALPK1 Gene

No Data Available

Interacting Proteins for ALPK1 Gene

STRING Interaction Network Preview (showing 3 interactants - click image to see details)
Selected Interacting proteins: ENSP00000177648 for ALPK1 Gene via STRING

Gene Ontology (GO) - Biological Process for ALPK1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002230 positive regulation of defense response to virus by host IMP 22020285
GO:0098792 xenophagy IMP 22020285
genes like me logo Genes that share ontologies with ALPK1: view

No data available for Pathways by source and SIGNOR curated interactions for ALPK1 Gene

Drugs & Compounds for ALPK1 Gene

No Compound Related Data Available

Transcripts for ALPK1 Gene

Unigene Clusters for ALPK1 Gene

Alpha-kinase 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ALPK1 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6 ^ 7a · 7b ^ 8 ^ 9a · 9b ^ 10 ^ 11a · 11b ^ 12a · 12b ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18a ·
SP1: - - - - - - - -
SP2: - - - - - - - - -
SP3: - - -
SP6: - -
SP8: -

ExUns: 18b

Relevant External Links for ALPK1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ALPK1 Gene

mRNA expression in normal human tissues for ALPK1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ALPK1 Gene

This gene is overexpressed in Whole Blood (x10.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ALPK1 Gene

SOURCE GeneReport for Unigene cluster for ALPK1 Gene Hs.652825

mRNA Expression by UniProt/SwissProt for ALPK1 Gene

Tissue specificity: Highly expressed in liver.
genes like me logo Genes that share expression patterns with ALPK1: view

Protein tissue co-expression partners for ALPK1 Gene

- Elite partner

Primer Products

No data available for Protein differential expression in normal tissues for ALPK1 Gene

Orthologs for ALPK1 Gene

This gene was present in the common ancestor of animals.

Orthologs for ALPK1 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia ALPK1 35
  • 83.44 (n)
  • 78.11 (a)
ALPK1 36
  • 78 (a)
(Canis familiaris)
Mammalia ALPK1 35
  • 85.24 (n)
  • 80.13 (a)
ALPK1 36
  • 80 (a)
(Mus musculus)
Mammalia Alpk1 35
  • 77.73 (n)
  • 72.43 (a)
Alpk1 16
Alpk1 36
  • 72 (a)
(Pan troglodytes)
Mammalia ALPK1 35
  • 99.28 (n)
  • 98.47 (a)
ALPK1 36
  • 98 (a)
(Rattus norvegicus)
Mammalia Alpk1 35
  • 77.04 (n)
  • 72.47 (a)
(Monodelphis domestica)
Mammalia ALPK1 36
  • 61 (a)
(Ornithorhynchus anatinus)
Mammalia ALPK1 36
  • 59 (a)
(Gallus gallus)
Aves ALPK1 35
  • 62.42 (n)
  • 55.79 (a)
ALPK1 36
  • 50 (a)
(Anolis carolinensis)
Reptilia ALPK1 36
  • 53 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia alpk1 35
  • 60.05 (n)
  • 55.24 (a)
(Danio rerio)
Actinopterygii ALPK1 36
  • 27 (a)
(Caenorhabditis elegans)
Secernentea efk-1 36
  • 10 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 11 (a)
CSA.7709 36
  • 14 (a)
Species with no ortholog for ALPK1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ALPK1 Gene

Gene Tree for ALPK1 (if available)
Gene Tree for ALPK1 (if available)

Paralogs for ALPK1 Gene

Paralogs for ALPK1 Gene

genes like me logo Genes that share paralogs with ALPK1: view

Variants for ALPK1 Gene

Sequence variations from dbSNP and Humsavar for ALPK1 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type
rs6533616 - 112,423,991(+) GCAAC(A/G)ATGGA intron-variant, reference, missense
rs2074388 - 112,431,241(+) CAATG(A/G)TGAGG reference, missense
rs13148353 - 112,431,472(+) ATTGC(A/G)TTCAC reference, missense
rs2074379 - 112,431,743(+) AATAT(A/G)GGCAC reference, missense
rs11726117 - 112,432,129(+) CAGCA(C/T)GGATG reference, missense

Structural Variations from Database of Genomic Variants (DGV) for ALPK1 Gene

Variant ID Type Subtype PubMed ID
esv2666363 CNV Deletion 23128226
esv26687 CNV Loss 19812545
nsv4470 CNV Insertion 18451855
esv2728152 CNV Deletion 23290073
esv2152267 CNV Deletion 18987734
esv994179 CNV Deletion 20482838
nsv291215 CNV Loss 16902084
esv2728153 CNV Deletion 23290073

Variation tolerance for ALPK1 Gene

Residual Variation Intolerance Score: 95.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.14; 75.67% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for ALPK1 Gene

Disorders for ALPK1 Gene

Relevant External Links for ALPK1

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for ALPK1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ALPK1 Gene

Publications for ALPK1 Gene

  1. Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10819331) Nagase T. … Ohara O. (DNA Res. 2000) 2 3 4 67
  2. Alpha-kinase 1, a new component in apical protein transport. (PMID: 15883161) Heine M. … Jacob R. (J. Biol. Chem. 2005) 3 23
  3. Alpha-kinases: a new class of protein kinases with a novel catalytic domain. (PMID: 10021370) Ryazanov A.G. … Dorovkov M.V. (Curr. Biol. 1999) 2 3
  4. Common variant of ALPK1 is not associated with gout: a replication study. (PMID: 25326865) Chiba T. … Shinomiya N. (Hum. Cell 2015) 3
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3

Products for ALPK1 Gene

Sources for ALPK1 Gene