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Aliases for ALPK1 Gene

Aliases for ALPK1 Gene

  • Alpha-Kinase 1 2 3
  • LAK 3 4 6
  • Lymphocyte Alpha-Protein Kinase 3 4
  • Lymphocyte Alpha-Kinase 2 3
  • Chromosome 4 Kinase 3 4
  • KIAA1527 4 6
  • Alpha-Protein Kinase 1 3
  • 8430410J10Rik 3
  • EC 2.7.11.- 4

External Ids for ALPK1 Gene

Summaries for ALPK1 Gene

Entrez Gene Summary for ALPK1 Gene

  • This gene encodes an alpha kinase. Mice which were homozygous for disrupted copies of this gene exhibited coordination defects (PMID: 21208416). Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011]

GeneCards Summary for ALPK1 Gene

ALPK1 (Alpha-Kinase 1) is a Protein Coding gene. GO annotations related to this gene include protein serine/threonine kinase activity. An important paralog of this gene is EEF2K.

UniProtKB/Swiss-Prot for ALPK1 Gene

  • Kinase that recognizes phosphorylation sites in which the surrounding peptides have an alpha-helical conformation

Gene Wiki entry for ALPK1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ALPK1 Gene

Genomics for ALPK1 Gene

Genomic Location for ALPK1 Gene

Start:
112,285,509 bp from pter
End:
112,442,620 bp from pter
Size:
157,112 bases
Orientation:
Plus strand

Genomic View for ALPK1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ALPK1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ALPK1 Gene

Regulatory Elements for ALPK1 Gene

Proteins for ALPK1 Gene

  • Protein details for ALPK1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96QP1-ALPK1_HUMAN
    Recommended name:
    Alpha-protein kinase 1
    Protein Accession:
    Q96QP1
    Secondary Accessions:
    • B4E3G1
    • F5H138
    • Q68CI9
    • Q6P9F9
    • Q6ZNK4
    • Q9P201

    Protein attributes for ALPK1 Gene

    Size:
    1244 amino acids
    Molecular mass:
    138861 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAC85140.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAC85140.1; Type=Frameshift; Positions=208, 1022; Evidence={ECO:0000305}; Sequence=BAC85140.1; Type=Miscellaneous discrepancy; Note=Intron retention.; Evidence={ECO:0000305}; Sequence=BC060780; Type=Frameshift; Positions=1044; Evidence={ECO:0000305};

    Alternative splice isoforms for ALPK1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ALPK1 Gene

Proteomics data for ALPK1 Gene at MOPED

Post-translational modifications for ALPK1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ALPK1 Gene

Domains for ALPK1 Gene

Gene Families for ALPK1 Gene

Protein Domains for ALPK1 Gene

InterPro:
ProtoNet:

UniProtKB/Swiss-Prot:

ALPK1_HUMAN
Domain:
  • Contains 1 alpha-type protein kinase domain.:
    • Q96QP1
Family:
  • Belongs to the protein kinase superfamily. Alpha-type protein kinase family. ALPK subfamily.:
    • Q96QP1
genes like me logo Genes that share domains with ALPK1: view

Function for ALPK1 Gene

Molecular function for ALPK1 Gene

UniProtKB/Swiss-Prot Function: Kinase that recognizes phosphorylation sites in which the surrounding peptides have an alpha-helical conformation

Enzyme Numbers (IUBMB) for ALPK1 Gene

Gene Ontology (GO) - Molecular Function for ALPK1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004674 protein serine/threonine kinase activity IEA --
GO:0005524 ATP binding IEA --
GO:0016301 kinase activity --
GO:0016772 transferase activity, transferring phosphorus-containing groups --
genes like me logo Genes that share ontologies with ALPK1: view

Phenotypes for ALPK1 Gene

genes like me logo Genes that share phenotypes with ALPK1: view

No data available for Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for ALPK1 Gene

Localization for ALPK1 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ALPK1 Gene COMPARTMENTS Subcellular localization image for ALPK1 gene
Compartment Confidence
cytoskeleton 1
cytosol 1
endoplasmic reticulum 1
mitochondrion 1
nucleus 1
peroxisome 1

No data available for Gene Ontology (GO) - Cellular Components for ALPK1 Gene

Pathways for ALPK1 Gene

SuperPathways for ALPK1 Gene

No Data Available

Interacting Proteins for ALPK1 Gene

STRING Interaction Network Preview (showing 3 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000177648%0d%0a9606.ENSP00000335153%0d%0a9606.ENSP00000325875%0d%0a9606.ENSP00000367207%0d%0a
Selected Interacting proteins: ENSP00000177648 for ALPK1 Gene via STRING

Gene Ontology (GO) - Biological Process for ALPK1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002230 positive regulation of defense response to virus by host IMP 22020285
GO:0006468 protein phosphorylation IEA --
GO:0016310 phosphorylation --
GO:0098779 activation of mitophagy in response to mitochondrial depolarization IMP 22020285
genes like me logo Genes that share ontologies with ALPK1: view

No data available for Pathways by source for ALPK1 Gene

Transcripts for ALPK1 Gene

Unigene Clusters for ALPK1 Gene

Alpha-kinase 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ALPK1 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6 ^ 7a · 7b ^ 8 ^ 9a · 9b ^ 10 ^ 11a · 11b ^ 12a · 12b ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18a ·
SP1: - - - - - - - -
SP2: - - - - - - - - -
SP3: - - -
SP4:
SP5:
SP6: - -
SP7:
SP8: -

ExUns: 18b
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:

Relevant External Links for ALPK1 Gene

GeneLoc Exon Structure for
ALPK1
ECgene alternative splicing isoforms for
ALPK1

Expression for ALPK1 Gene

mRNA expression in normal human tissues for ALPK1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ALPK1 Gene

This gene is overexpressed in Whole Blood (10.4).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for ALPK1 Gene

SOURCE GeneReport for Unigene cluster for ALPK1 Gene Hs.652825

mRNA Expression by UniProt/SwissProt for ALPK1 Gene

Q96QP1-ALPK1_HUMAN
Tissue specificity: Highly expressed in liver.
genes like me logo Genes that share expressions with ALPK1: view

Orthologs for ALPK1 Gene

This gene was present in the common ancestor of animals.

Orthologs for ALPK1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ALPK1 36
  • 99.28 (n)
  • 98.47 (a)
ALPK1 37
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ALPK1 36
  • 83.44 (n)
  • 78.11 (a)
ALPK1 37
  • 78 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ALPK1 36
  • 85.24 (n)
  • 80.13 (a)
ALPK1 37
  • 80 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Alpk1 36
  • 77.73 (n)
  • 72.43 (a)
Alpk1 16
Alpk1 37
  • 72 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ALPK1 37
  • 61 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ALPK1 37
  • 59 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Alpk1 36
  • 77.04 (n)
  • 72.47 (a)
chicken
(Gallus gallus)
Aves ALPK1 36
  • 62.42 (n)
  • 55.79 (a)
ALPK1 37
  • 50 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ALPK1 37
  • 53 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia alpk1 36
  • 60.05 (n)
  • 55.24 (a)
zebrafish
(Danio rerio)
Actinopterygii ALPK1 37
  • 27 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea efk-1 37
  • 10 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 11 (a)
ManyToMany
CSA.7709 37
  • 14 (a)
ManyToMany
Species with no ortholog for ALPK1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ALPK1 Gene

ENSEMBL:
Gene Tree for ALPK1 (if available)
TreeFam:
Gene Tree for ALPK1 (if available)

Paralogs for ALPK1 Gene

Paralogs for ALPK1 Gene

genes like me logo Genes that share paralogs with ALPK1: view

Variants for ALPK1 Gene

Sequence variations from dbSNP and Humsavar for ALPK1 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type MAF
rs231245 -- 112,437,603(+) GGTAT(A/G)GCATC intron-variant
rs231246 -- 112,438,103(+) GGAAG(G/T)CTTCA intron-variant
rs231247 -- 112,438,547(+) GAGCG(A/G)CAGAT reference, synonymous-codon
rs231248 -- 112,438,727(+) CACAT(A/T)ATCAG intron-variant
rs231249 -- 112,438,888(+) TGATT(A/G)CTAAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ALPK1 Gene

Variant ID Type Subtype PubMed ID
esv2666363 CNV Deletion 23128226
esv26687 CNV Loss 19812545
nsv4470 CNV Insertion 18451855
esv2728152 CNV Deletion 23290073
esv2152267 CNV Deletion 18987734
esv994179 CNV Deletion 20482838
nsv291215 CNV Loss 16902084
esv2728153 CNV Deletion 23290073

Relevant External Links for ALPK1 Gene

HapMap Linkage Disequilibrium report
ALPK1

Disorders for ALPK1 Gene

Relevant External Links for ALPK1

Genetic Association Database (GAD)
ALPK1
Human Genome Epidemiology (HuGE) Navigator
ALPK1
genes like me logo Genes that share disorders with ALPK1: view

No data available for UniProtKB/Swiss-Prot for ALPK1 Gene

Publications for ALPK1 Gene

  1. Alpha-kinases: a new class of protein kinases with a novel catalytic domain. (PMID: 10021370) Ryazanov A.G. … Dorovkov M.V. (Curr. Biol. 1999) 2 3 4
  2. Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10819331) Nagase T. … Ohara O. (DNA Res. 2000) 2 3 4
  3. Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones. (PMID: 12168954) Nakajima D. … Nagase T. (DNA Res. 2002) 3 4
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  5. Expression profiling and differential screening between hepatoblastomas and the corresponding normal livers: identification of high expression of the PLK1 oncogene as a poor-prognostic indicator of hepatoblastomas. (PMID: 15221005) Yamada S. … Nakagawara A. (Oncogene 2004) 3 4

Products for ALPK1 Gene

  • Addgene plasmids for ALPK1

Sources for ALPK1 Gene

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