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ALPK1 Gene

protein-coding   GIFtS: 50
GCID: GC04P113218

Alpha-Kinase 1

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Alpha-Kinase 11 2     KIAA15273 5
LAK2 3 5     8430410J10Rik2
Lymphocyte Alpha-Kinase1 2     Alpha-Protein Kinase 12
Chromosome 4 Kinase2 3     EC 2.7.11.-3
Lymphocyte Alpha-Protein Kinase2 3     

External Ids:    HGNC: 209171   Entrez Gene: 802162   Ensembl: ENSG000000733317   OMIM: 6073475   UniProtKB: Q96QP13   

Export aliases for ALPK1 gene to outside databases

Previous GC identifers: GC04P113657 GC04P113438 GC04P108950


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for ALPK1 Gene:
This gene encodes an alpha kinase. Mice which were homozygous for disrupted copies of this gene exhibited
coordination defects (PMID: 21208416). Multiple transcript variants encoding different isoforms have been found
for this gene. (provided by RefSeq, Dec 2011)

GeneCards Summary for ALPK1 Gene:
ALPK1 (alpha-kinase 1) is a protein-coding gene. GO annotations related to this gene include protein serine/threonine kinase activity. An important paralog of this gene is EEF2K.

UniProtKB/Swiss-Prot: ALPK1_HUMAN, Q96QP1
Function: Kinase that recognizes phosphorylation sites in which the surrounding peptides have an alpha-helical
conformation

Gene Wiki entry for ALPK1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000004.11  NT_016354.20  NC_018915.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the ALPK1 gene promoter:
         AP-2rep   AP-1   HOXA3   FOXO3   Ik-3   FOXO3b   SRY   STAT3   IRF-7A   FOXO3a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): ALPK1 promoter sequence
   Search Chromatin IP Primers for ALPK1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ALPK1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4q25   Ensembl cytogenetic band:  4q25   HGNC cytogenetic band: 4q26

ALPK1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ALPK1 gene location

GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04P113218:  view genomic region     (about GC identifiers)

Start:
113,206,665 bp from pter      End:
113,363,776 bp from pter
Size:
157,112 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: ALPK1_HUMAN, Q96QP1 (See protein sequence)
Recommended Name: Alpha-protein kinase 1  
Size: 1244 amino acids; 138861 Da
Sequence caution: Sequence=BAC85140.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Sequence=BAC85140.1; Type=Frameshift; Positions=208, 1022; Sequence=BAC85140.1; Type=Miscellaneous discrepancy;
Note=Intron retention; Sequence=BC060780; Type=Frameshift; Positions=1044;
Secondary accessions: B4E3G1 F5H138 Q68CI9 Q6P9F9 Q6ZNK4 Q9P201
Alternative splicing: 2 isoforms:  Q96QP1-1   Q96QP1-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for ALPK1: NX_Q96QP1

Explore proteomics data for ALPK1 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See ALPK1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001095876.1  NP_001240813.1  NP_079420.3  

    ENSEMBL proteins: 
     ENSP00000177648   ENSP00000424492   ENSP00000425559   ENSP00000423978   ENSP00000425273  
     ENSP00000398048   ENSP00000426044  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    IUPHAR Guide to PHARMACOLOGY protein family classification: alpha-kinase 1
    Other alpha kinase family kinases

    2 InterPro protein domains:
     IPR011009 Kinase-like_dom
     IPR004166 MHCK_EF2_kinase

    Graphical View of Domain Structure for InterPro Entry Q96QP1

    ProtoNet protein and cluster: Q96QP1

    UniProtKB/Swiss-Prot: ALPK1_HUMAN, Q96QP1
    Similarity: Belongs to the protein kinase superfamily. Alpha-type protein kinase family. ALPK subfamily
    Similarity: Contains 1 alpha-type protein kinase domain


    Find genes that share domains with ALPK1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ALPK1_HUMAN, Q96QP1
    Function: Kinase that recognizes phosphorylation sites in which the surrounding peptides have an alpha-helical
    conformation

         Enzyme Number (IUBMB): EC 2.7.11.-1

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004674protein serine/threonine kinase activity IEA--
    GO:0005524ATP binding IEA--
    GO:0016301kinase activity ----
    GO:0016772transferase activity, transferring phosphorus-containing groups ----
         
    Find genes that share ontologies with ALPK1           About GenesLikeMe


    Phenotypes:
         3 GenomeRNAi human phenotypes for ALPK1:
     Decreased viability with RAF26  Increased cell death HMECs cel  Synthetic lethal with paclitax 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for ALPK1
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    3 qRT-PCR Assays for microRNAs that regulate ALPK1:
    hsa-miR-135b hsa-miR-4272 hsa-miR-135a
    SwitchGear 3'UTR luciferase reporter plasmidALPK1 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat ALPK1

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    Addgene plasmids for ALPK1 

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytoskeleton1
    cytosol1
    endoplasmic reticulum1
    mitochondrion1
    nucleus1
    peroxisome1

    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for ALPK1
    Interactions:

        Search GeneGlobe Interaction Network for ALPK1

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    1 Interacting protein for ALPK1 (ENSP000001776484) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MYCENSP000003672074STRING: ENSP00000367207
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006468protein phosphorylation ----

    Find genes that share ontologies with ALPK1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ALPK1



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for ALPK1 gene (3 alternative transcripts): 
    NM_001102406.1  NM_001253884.1  NM_025144.3  

    Unigene Cluster for ALPK1:

    Alpha-kinase 1
    Hs.652825  [show with all ESTs]
    Unigene Representative Sequence: AK131090
    18 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000514594 ENST00000505176 ENST00000177648 ENST00000502366 ENST00000509722
    ENST00000505127 ENST00000504488 ENST00000509688(uc003iam.3) ENST00000426472
    ENST00000515330(uc011cfw.1) ENST00000515106 ENST00000504745(uc010imo.3)
    ENST00000505912 ENST00000509209 ENST00000508589 ENST00000512847 ENST00000458497(uc003ian.4 uc003iap.4 uc011cfx.2 uc003iao.4)
    ENST00000504176
    miRNA
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    3 qRT-PCR Assays for microRNAs that regulate ALPK1:
    hsa-miR-135b hsa-miR-4272 hsa-miR-135a
    SwitchGear 3'UTR luciferase reporter plasmidALPK1 3' UTR sequence
    Inhib. RNA
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    GenScript: all cDNA clones in your preferred vector (see all 2): ALPK1 (NM_025144)
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    Addgene plasmids for ALPK1 
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    OriGene qPCR primer pairs and template standards for ALPK1
    OriGene qSTAR qPCR primer pairs in human, mouse for ALPK1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat ALPK1
      QuantiTect SYBR Green Assays in human, mouse, rat ALPK1
      QuantiFast Probe-based Assays in human, mouse, rat ALPK1

    Additional mRNA sequence: 

    AB040960.1 AB075877.1 AK026323.1 AK026715.1 AK091872.1 AK097246.1 AK131090.1 AK303489.1 
    AK304708.1 AY044164.1 BC028117.1 BC060780.1 BX648798.1 

    14 DOTS entries:

    DT.100711189  DT.308227  DT.100752069  DT.308244  DT.97838581  DT.99938795  DT.75126013  DT.100692258 
    DT.91694344  DT.40115121  DT.91650375  DT.121246011  DT.91792429  DT.97801632 

    Selected AceView cDNA sequences (see all 108):

    AA443919 AI274270 CR590073 AI056941 BE887913 AA235361 AW051462 AI510764 
    BC060780 AK097246 AA307490 AA521335 AI660860 AL710267 AI089189 AK091872 
    AA361352 AL538538 AL599544 BQ026899 CB993532 CB160991 BC028117 BV170397 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for ALPK1 (see all 8)    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6 ^ 7a · 7b ^ 8 ^ 9a · 9b ^ 10 ^ 11a · 11b ^ 12a · 12b ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18a ·
    SP1:                    -     -     -     -                 -     -           -                                         -                                       
    SP2:                    -     -     -     -                 -     -           -                                         -     -                                 
    SP3:                                                        -     -           -                                                                                 
    SP4:                                                                                                                                                            
    SP5:                                                                                                                                                            

    ExUns: 18b
    SP1:      
    SP2:      
    SP3:      
    SP4:      
    SP5:      


    ECgene alternative splicing isoforms for ALPK1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ALPK1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TACCCCTGAA
    ALPK1 Expression
    About this image


    ALPK1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 5) fully expand
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
     
     Ovary (Reproductive System)    fully expand to see all 2 entries
             Pre-Granulosa Cells Primordial Follicle
     
     Thymus (Hematopoietic System)
             Double Positive Thymocytes Thymus
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
     
     Blood (Cardiovascular System)
             Double Positive Thymocytes Thymus
    ALPK1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ALPK1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.652825

    UniProtKB/Swiss-Prot: ALPK1_HUMAN, Q96QP1
    Tissue specificity: Highly expressed in liver

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ALPK1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for ALPK1 gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Alpk11 , 5 alpha-kinase 11, 5 77.73(n)1
    72.43(a)1
      3 (56.54 cM)5
    714811  NM_027808.11  NP_082084.11 
     1276703995 
    chicken
    (Gallus gallus)
    Aves ALPK11 alpha-kinase 1 62.42(n)
    55.79(a)
      100858173  XM_004935949.1  XP_004936006.1 
    lizard
    (Anolis carolinensis)
    Reptilia ALPK16
    alpha-kinase 1
    53(a)
    1 ↔ 1
    5(143082607-143154959)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia alpk11 alpha-kinase 1 60.05(n)
    55.24(a)
      100036729  NM_001097274.1  NP_001090743.1 
    zebrafish
    (Danio rerio)
    Actinopterygii ALPK16
    alpha-kinase 1
    27(a)
    1 ↔ 1
    7(1073984-1097213) ENSDARG00000059741
    worm
    (Caenorhabditis elegans)
    Secernentea efk-16
    Protein EFK-1, isoform b (efk-1) mRNA, complete cd...
    10(a)
    1 → many
    III(6164919-6168547) WBGene00001160


    ENSEMBL Gene Tree for ALPK1 (if available)
    TreeFam Gene Tree for ALPK1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for ALPK1 gene
    EEF2K2  

    Find genes that share paralogs with ALPK1           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ALPK1 (see all 2900)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 4 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0415144
    An ovarian mucinous carcinoma sample4--see VAR_0415142 K E mis40--------
    rs1848302771,2
    Cuntested1113352999(+) AGCAGA/C/GGAGAA 6 R G mis10--------
    rs793757441,2
    C--113216572(+) TTTCCA/GTAACC 3 -- us2k10--------
    rs1477666321,2
    C--113216602(+) ATCCAC/TAGAAG 3 -- us2k10--------
    rs1410861271,2
    C--113216702(+) AGCCTA/GTAATC 3 -- us2k10--------
    rs1820766261,2
    --113216758(+) AGTTCA/GAGACC 3 -- us2k10--------
    rs1469360791,2
    --113216817(+) AGCTGC/GGCGTG 3 -- us2k10--------
    rs1863285031,2
    --113216863(+) CTGAGA/GCAGGA 3 -- us2k10--------
    rs1915947001,2
    --113216873(+) AGAATC/TGCTTG 3 -- us2k10--------
    rs1476287671,2
    --113216990(+) TGGGTA/GTGGTG 3 -- us2k10--------

    HapMap Linkage Disequilibrium report for ALPK1 (113206665 - 113363776 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 8 variations for ALPK1:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2728152CNV Deletion23290073
    esv2666363CNV Deletion23128226
    esv994179CNV Deletion20482838
    esv2728153CNV Deletion23290073
    esv2152267CNV Deletion18987734
    nsv4470CNV Insertion18451855
    esv26687CNV Loss19812545
    nsv291215CNV Loss16902084

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 607347    OMIM disorders: --


    Find genes that share disorders with ALPK1           About GenesLikeMe

    Genetic Association Database (GAD): ALPK1
    Human Genome Epidemiology (HuGE) Navigator: ALPK1 (1 document)

    Export disorders for ALPK1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ALPK1 gene, integrated from 10 sources (see all 22):
    (articles sorted by number of sources associating them with ALPK1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10819331)1, 2, 3 Nagase T.... Ohara O. (DNA Res. 2000)
    2. Alpha-kinases: a new class of protein kinases with a novel catalytic domain. (PubMed id 10021370)1, 2, 3 Ryazanov A.G.... Dorovkov M.V. (Curr. Biol. 1999)
    3. A genome-wide association meta-analysis identifies new childhood obesity loci. (PubMed id 22484627)1, 4 Bradfield J.P....Grant S.F. (Nat. Genet. 2012)
    4. Genome-wide association study of epirubicin-induced leukopenia in Japanese patients. (PubMed id 21799462)1, 4 Srinivasan Y....Zembutsu H. (Pharmacogenet. Genomics 2011)
    5. A systematic gene-based screen of chr4q22-q32 identifies association of a novel susceptibility gene, DKK2, with the quantitative trait of alcohol dependence symptom counts. (PubMed id 20332099)1, 4 Kalsi G....Riley B.P. (Hum. Mol. Genet. 2010)
    6. Expression profiling and differential screening between hepatoblastomas and the corresponding normal livers: identification of high expression of the PLK1 oncogene as a poor-prognostic indicator of hepatoblastomas. (PubMed id 15221005)1, 2 Yamada S....Nakagawara A. (Oncogene 2004)
    7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    8. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    9. Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones. (PubMed id 12168954)1, 2 Nakajima D.... Nagase T. (DNA Res. 2002)
    10. Alpha-kinase 1, a new component in apical protein transport. (PubMed id 15883161)1, 9 Heine M....Jacob R. (J. Biol. Chem. 2005)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
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    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 80216 HGNC: 20917 AceView: LAK Ensembl:ENSG00000073331 euGenes: HUgn80216
    ECgene: ALPK1 H-InvDB: ALPK1

    (According to HUGE)
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    HUGE: KIAA1527

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for ALPK1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for ALPK1 gene:
    Search GeneIP for patents involving ALPK1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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