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ALPI Gene

protein-coding   GIFtS: 68
GCID: GC02P233320

Alkaline Phosphatase, Intestinal

  See ALPI-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Alkaline Phosphatase, Intestinal1 2     Alkaline Phosphomonoesterase2
Intestinal Alkaline Phosphatase2 3     glycerophosphatase2
IAP2 3     Intestinal-Type Alkaline Phosphatase2
EC 3.1.3.13 8     Kasahara Isozyme2

External Ids:    HGNC: 4371   Entrez Gene: 2482   Ensembl: ENSG000001632957   OMIM: 1717405   UniProtKB: P099233   

Export aliases for ALPI gene to outside databases

Previous GC identifers: GC02P231377 GC02P232050 GC02P233284 GC02P233523 GC02P233146 GC02P233029 GC02P225171


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for ALPI Gene:
There are at least four distinct but related alkaline phosphatases: intestinal, placental, placental-like, and
liver/bone/kidney (tissue non-specific). The intestinal alkaline phosphatase gene encodes a digestive
brush-border enzyme. This enzyme is upregulated during small intestinal epithelial cell differentiation.
(provided by RefSeq, Jul 2008)

GeneCards Summary for ALPI Gene:
ALPI (alkaline phosphatase, intestinal) is a protein-coding gene. Diseases associated with ALPI include soft palate cancer, and gastrointestinal system disease. GO annotations related to this gene include alkaline phosphatase activity. An important paralog of this gene is ALPPL2.

Gene Wiki entry for ALPI Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000002.11  NT_005403.18  NC_018913.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the ALPI gene promoter:
         AhR   Pax-5   NCX/Ncx   C/EBPalpha   Evi-1   Arnt   GATA-1   Meis-1b   Meis-1a   Meis-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidALPI promoter sequence
   Search Chromatin IP Primers for ALPI

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ALPI


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q37.1   Ensembl cytogenetic band:  2q37.1   HGNC cytogenetic band: 2q37.1

ALPI Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ALPI gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02P233320:  view genomic region     (about GC identifiers)

Start:
233,320,833 bp from pter      End:
233,324,742 bp from pter
Size:
3,910 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: PPBI_HUMAN, P09923 (See protein sequence)
Recommended Name: Intestinal-type alkaline phosphatase precursor  
Size: 528 amino acids; 56812 Da
Cofactor: Binds 1 magnesium ion (By similarity)
Cofactor: Binds 2 zinc ions (By similarity)
Subunit: Homodimer
Miscellaneous: In most mammals there are four different isozymes: placental, placental-like, intestinal and tissue
non-specific (liver/bone/kidney)
Secondary accessions: B2R7Y4 Q53S80 Q9UBV5 Q9UCL2

Explore the universe of human proteins at neXtProt for ALPI: NX_P09923

Explore proteomics data for ALPI at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn141, Asn268, Asn429
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for ALPI (P09923) (see all 19)
     TTRGNEV  VEGGRID  NLVQEWL  GVVTTTR 


    See ALPI Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_001622.2  
    ENSEMBL proteins: 
     ENSP00000295463   ENSP00000413068  

    ALPI Human Recombinant Protein Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    4 InterPro protein domains:
     IPR001952 Alkaline_phosphatase
     IPR017849 Alkaline_Pase-like_a/b/a
     IPR017850 Alkaline_phosphatase_core
     IPR018299 Alkaline_phosphatase_AS

    Graphical View of Domain Structure for InterPro Entry P09923

    ProtoNet protein and cluster: P09923

    1 Blocks protein domain: IPB001952 Alkaline phosphatase

    UniProtKB/Swiss-Prot: PPBI_HUMAN, P09923
    Similarity: Belongs to the alkaline phosphatase family


    Find genes that share domains with ALPI           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: PPBI_HUMAN, P09923
    Catalytic activity: A phosphate monoester + H(2)O = an alcohol + phosphate

         Genatlas biochemistry entry for ALPI:
    phosphatase alkaline,intestinal

         Enzyme Number (IUBMB): EC 3.1.3.11 2

         Gene Ontology (GO): Selected molecular function terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000287magnesium ion binding ISS--
    GO:0003824catalytic activity ----
    GO:0004035alkaline phosphatase activity NAS2841341
    GO:0008270zinc ion binding ISS--
    GO:0016791phosphatase activity ----
         
    Find genes that share ontologies with ALPI           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for ALPI:
     Decreased focal adhesion (FA)  

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for ALPI
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       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for ALPI

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    hsa-mir-26b-5p (MIRT029513), hsa-mir-148b-3p (MIRT019330)

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    Inhib. RNA
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    PPBI_HUMAN, P09923: Cell membrane; Lipid-anchor, GPI-anchor
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5
    extracellular2
    cytosol1
    endoplasmic reticulum1
    lysosome1
    mitochondrion1
    nucleus1

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane IEA--
    GO:0016020membrane ----
    GO:0016021integral component of membrane IEA--
    GO:0031225anchored component of membrane IEA--

    Find genes that share ontologies with ALPI           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for ALPI About    
    See pathways by source

    SuperPathContained pathways About
    1Nicotinate and nicotinamide metabolism
    NAD metabolism0.43
    2Metabolism
    Metabolic pathways0.38
    3Folate biosynthesis
    Folate biosynthesis


    Find genes that share SuperPaths with ALPI           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 GeneGo (Thomson Reuters) Pathway for ALPI
        NAD metabolism



    2 Kegg Pathways  (Kegg details for ALPI):
        Folate biosynthesis
    Metabolic pathways

        Pathway & Disease-focused RT2 Profiler PCR Array including ALPI: 
              Stem Cells in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for ALPI

    STRING Interaction Network Preview (showing 5 interactants - click image to see 20)

    Selected Interacting proteins for ALPI (P099233 ENSP000002954634) via UniProtKB, MINT, STRING, and/or I2D (see all 20)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    EIF4A2Q142403, ENSP000003263814I2D: score=2 STRING: ENSP00000326381
    BICD1Q96G013, ENSP000002814744I2D: score=1 STRING: ENSP00000281474
    IRF5Q135683, ENSP000003497704I2D: score=1 STRING: ENSP00000349770
    PTSENSP000002803624STRING: ENSP00000280362
    GCH1ENSP000003788904STRING: ENSP00000378890
    About this table

    Gene Ontology (GO): 3 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008152metabolic process ----
    GO:0016310phosphorylation ----
    GO:0016311dephosphorylation ISS--

    Find genes that share ontologies with ALPI           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ALPI (PPBI)

    Selected HMDB Compounds for ALPI (see all 15)    About this table
    CompoundSynonyms CAS #PubMed Ids
    1-Butanol1-Butanol (see all 10)71-36-3--
    1-Hexanol1-Hexyl alcohol (see all 30)111-27-3--
    1-Pentanol1-Pentol (see all 34)71-41-0--
    4-Nitrophenol1-Hydroxy-4-nitrobenzene (see all 8)100-02-7--
    7,8-Dihydroneopterin2-Amino-4-hydroxy-6-(D-erythro-1',2',3'-trihydroxypropyl)-7,8-dihydropteridine (see all 11)1218-98-0--
    Dihydroneopterin triphosphate2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl) dihydropteridine triphosphate (see all 5)20574-65-6--
    Dihydroxyacetone1,3-Dihydroxy-2-propanone (see all 21)96-26-4--
    Dihydroxyacetone phosphate1,3-Dihydroxy-2-propanone phosphate (see all 17)57-04-5--
    Ethanol1-Hydroxyethane (see all 57)64-17-5--
    Isobutanol1-Hydroxymethylpropane (see all 18)78-83-1--

    Selected Novoseek inferred chemical compound relationships for ALPI gene (see all 31)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    glutathione monoester 76.8 1 11423381 (1)
    p-nitrophenyl phosphate 70.1 1 8174763 (1)
    d,l-buthionine-s,r-sulfoximine 61.1 5 11423381 (4), 8916550 (1)
    butyrate 56.3 8 2328777 (2), 10455897 (1), 15765403 (1), 11313308 (1) (see all 5)
    fosphenytoin 55.1 1 8592691 (1)
    sodium orthovanadate 45.2 1 7929029 (1)
    thiamine pyrophosphate 44.4 1 15802905 (1)
    phosphoethanolamine 36.9 1 8174763 (1)
    phytate 34.8 2 7769385 (1), 1880499 (1)
    zinc 31.6 4 13678301 (2), 12945337 (1)



    Find genes that share compounds with ALPI           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for ALPI gene: 
    NM_001631.3  

    Unigene Cluster for ALPI:

    Alkaline phosphatase, intestinal
    Hs.37009  [show with all ESTs]
    Unigene Representative Sequence: NM_001631
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000295463(uc002vst.4 uc002vsu.4) ENST00000457560
    miRNA
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    Additional mRNA sequence: 

    AK313163.1 BC132678.1 M15694.1 M31008.1 

    2 DOTS entries:

    DT.100681926  DT.95362888 

    10 AceView cDNA sequences:

    M21499 AW450908 M31008 BP382856 NM_001631 BP382969 M15694 AH002601 
    BP383175 AU076770 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for ALPI    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7
    SP1:                                                
    SP2:                                                
    SP3:                                                


    ECgene alternative splicing isoforms for ALPI

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ALPI expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GGCCCTCCCG
    ALPI Expression
    About this image


    ALPI expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 3) fully expand
     
     Inner Cell Mass (Early Embryonic Tissues)    fully expand to see all 2 entries
             Human embryonic stem cells (family)
     
     Epithelial Cells
             Proximal Tubule Cells Proximal Tubule
     
     Kidney (Urinary System)
             Proximal Tubule Cells Proximal Tubule
    ALPI Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ALPI Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.37009
        Pathway & Disease-focused RT2 Profiler PCR Array including ALPI: 
              Stem Cells in human mouse rat

    Primer
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ALPI

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for ALPI gene from Selected species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Alpi5
    Akp31
    alkaline phosphatase, intestinal5
    alkaline phosphatase 3, intestine, not Mn requiring1
    80.39(n)1
    80.52(a)1
      1 (44.05 cM)5
    116481  NM_007432.21  NP_031458.21 
     870980025 
    chicken
    (Gallus gallus)
    Aves ALPP1 alkaline phosphatase, placental 71.05(n)
    71.34(a)
      100859876  XM_003641761.2  XP_003641809.1 
    lizard
    (Anolis carolinensis)
    Reptilia --
    Alkaline phosphatase
    63(a)
    1 → many
    GL343304.1(677973-694404)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia alpi.11 alkaline phosphatase, intestinal, gene 1 63.5(n)
    67.98(a)
      548375  XM_002937341.2  XP_002937387.2 
    zebrafish
    (Danio rerio)
    Actinopterygii alpi.21 alkaline phosphatase, intestinal, tandem duplicate more 62.15(n)
    63.77(a)
      574009  NM_001025188.1  NP_001020359.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG18093
    CG108271
    alkaline phosphatase3
    CG108271
    43(a)
    (best of 11)3
    54.77(n)1
    44.71(a)1
      45F33
    424821  NM_142674.41  NP_650931.11 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes PHO86
    Repressible vacuolar alkaline phosphatase; regulat...
    21(a)
    1 → many
    IV(1418550-1420250) YDR481C


    ENSEMBL Gene Tree for ALPI (if available)
    TreeFam Gene Tree for ALPI (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for ALPI gene
    ALPPL22  ALPL2  ALPP2  
    3 SIMAP similar genes for ALPI using alignment to 2 protein entries:     PPBI_HUMAN (see all proteins):
    ALPPL2    ALPP    ALPL

    Find genes that share paralogs with ALPI           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ALPI (see all 256)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1497049421,2
    --233318851(+) GCAGGA/GGTGAG 1 -- us2k10--------
    rs1878838151,2
    --233318955(+) CTCAGC/TTCACT 1 -- us2k10--------
    rs1925647921,2
    --233319095(+) AGCCAC/GGATGG 1 -- us2k10--------
    rs1114384271,2
    F--233319134(+) CACCTC/TGGCCT 1 -- us2k11Minor allele frequency- T:0.50CSA 2
    rs1832347201,2
    --233319224(+) TCTGTC/TAAAAA 1 -- us2k10--------
    rs1881567091,2
    --233319390(+) TAGAGA/GAAACT 1 -- us2k10--------
    rs1488263341,2
    --233319400(+) TAAGGA/GGGCAA 1 -- us2k10--------
    rs724821051,2
    C--233319499(+) GAGGAC/TCCGGG 1 -- us2k14Minor allele frequency- T:0.05WA NA EA 360
    rs28534111,2
    C,F--233319502(+) GACCCG/AGGAAA 1 -- us2k13Minor allele frequency- A:0.04WA NA EA 358
    rs1470008661,2
    C--233319512(+) AGCTCA/GGCCTG 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for ALPI (233320833 - 233324742 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for ALPI (see all 12):    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv527789CNV Loss19592680
    nsv875977CNV Loss21882294
    nsv875998CNV Loss21882294
    nsv522450CNV Loss19592680
    nsv875999CNV Loss21882294
    dgv4450n71CNV Loss21882294
    nsv482060CNV Gain20164927
    nsv821918CNV Gain20364138
    dgv4449n71CNV Gain21882294
    dgv494n27CNV Gain19166990

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 171740    OMIM disorders: --

    4 diseases for ALPI:    
    About MalaCards
    soft palate cancer    gastrointestinal system disease    seminoma    hypophosphatasia

    2 diseases from the University of Copenhagen DISEASES database for ALPI:
    Soft palate cancer     Gastrointestinal system disease

    Find genes that share disorders with ALPI           About GenesLikeMe

    10 Novoseek inferred disease relationships for ALPI gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    colon cancer 46.7 2 15774940 (1), 16378595 (1)
    neoplastic transformation 35.4 2 7597142 (1), 8664049 (1)
    microalbuminuria 19.9 1 9816378 (1)
    seminoma 17.5 1 8434423 (1)
    liver cirrhosis 6.4 1 1424160 (1)
    bacterial infections 1.62 5 8811051 (2), 9097906 (2), 7899830 (1)
    inflammatory bowel diseases 0 1 17498884 (1)
    metastasis 0 1 16959714 (1)
    tumors 0 5 8434423 (1), 8946869 (1), 11578255 (1), 12577238 (1) (see all 5)
    cancer 0 2 9548446 (1)

    Genetic Association Database (GAD): ALPI

    Export disorders for ALPI gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ALPI gene, integrated from 10 sources (see all 171):
    (articles sorted by number of sources associating them with ALPI)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning and sequencing of human intestinal alkaline phosphatase cDNA. (PubMed id 3468508)1, 2, 3 Berger J.... Udenfriend S. (Proc. Natl. Acad. Sci. U.S.A. 1987)
    2. Nucleotide and amino acid sequences of human intestinal alkaline phosphatase: close homology to placental alkaline phosphatase. (PubMed id 3469665)1, 2, 3 Henthorn P.S.... Harris H. (Proc. Natl. Acad. Sci. U.S.A. 1987)
    3. Chemical nature of intestinal-type alkaline phosphatase in human kidney. (PubMed id 1458595)1, 2, 9 Nishihara Y....Hirano K. (Clin. Chem. 1992)
    4. Sequence and characterization of the human intestinal alkaline phosphatase gene. (PubMed id 2841341)1, 2 Henthorn P.S.... Harris H. (J. Biol. Chem. 1988)
    5. Promoter structure of the human intestinal alkaline phosphatase gene. (PubMed id 3697102)1, 2 Millan J.L. (Nucleic Acids Res. 1987)
    6. Two gene duplication events in the evolution of the human heat-stable alkaline phosphatases. (PubMed id 3443302)1, 2 Knoll B.J.... Longley M. (Gene 1987)
    7. Partial sequencing of human adult, human fetal, and bovine intestinal alkaline phosphatases: comparison with the human placental and liver isozymes. (PubMed id 3458202)1, 2 Hua J.-C.... Udenfriend S. (Proc. Natl. Acad. Sci. U.S.A. 1986)
    8. Differentiation-dependent activation of the human intestinal alkaline phosphatase promoter by HNF-4 in intestinal cells. (PubMed id 15831710)1, 9 Olsen L....Olsen J. (Am. J. Physiol. Gastrointest. Liver Physiol. 2005)
    9. Placental and intestinal alkaline phosphatases are receptors for Aeromonas sobria hemolysin. (PubMed id 15715171)1, 9 Wada A....Hirayama T. (Int. J. Med. Microbiol. 2005)
    10. Differential regulation of intestinal alkaline phosphatase gene expression by Cdx1 and Cdx2. (PubMed id 15774940)1, 9 Alkhoury F....Hodin R.A. (Am. J. Physiol. Gastrointest. Liver Physiol. 2005)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 248 HGNC: 437 AceView: ALPI Ensembl:ENSG00000163295 euGenes: HUgn248
    ECgene: ALPI Kegg: 248 H-InvDB: ALPI

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for ALPI Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for ALPI Genetics and Cytogenetics in Oncology and Haematology
    Wikipedia http://en.wikipedia.org/wiki/Alkaline_phosphatase

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for ALPI gene:
    Search GeneIP for patents involving ALPI

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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