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Aliases for ALPI Gene

Aliases for ALPI Gene

  • Alkaline Phosphatase, Intestinal 2 3 5
  • Intestinal Alkaline Phosphatase 3 4
  • EC 3.1.3.1 4 61
  • IAP 3 4
  • Intestinal-Type Alkaline Phosphatase 3
  • Alkaline Phosphomonoesterase 3
  • Glycerophosphatase 3
  • Kasahara Isozyme 3

External Ids for ALPI Gene

Previous GeneCards Identifiers for ALPI Gene

  • GC02P231377
  • GC02P232050
  • GC02P233284
  • GC02P233523
  • GC02P233146
  • GC02P233029
  • GC02P233320
  • GC02P225171

Summaries for ALPI Gene

Entrez Gene Summary for ALPI Gene

  • There are at least four distinct but related alkaline phosphatases: intestinal, placental, placental-like, and liver/bone/kidney (tissue non-specific). The intestinal alkaline phosphatase gene encodes a digestive brush-border enzyme. This enzyme is a component of the gut mucosal defense system and is thought to function in the detoxification of lipopolysaccharide, and in the prevention of bacterial translocation in the gut. [provided by RefSeq, Dec 2014]

GeneCards Summary for ALPI Gene

ALPI (Alkaline Phosphatase, Intestinal) is a Protein Coding gene. Diseases associated with ALPI include Testis Seminoma. Among its related pathways are Thiamine metabolism and Post-translational modification- synthesis of GPI-anchored proteins. GO annotations related to this gene include magnesium ion binding and protease binding. An important paralog of this gene is ALPPL2.

Gene Wiki entry for ALPI Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ALPI Gene

Genomics for ALPI Gene

Regulatory Elements for ALPI Gene

Enhancers for ALPI Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH02G232500 1.4 FANTOM5 Ensembl ENCODE 1.4 +46.2 46235 3.3 ATF1 SUZ12 ZMYM3 BRCA1 POLR2A EGR1 NFE2 CREM EZH2 STAT1 TIGD1 CHRNG PRSS56 ECEL1 ALPP ALPI GIGYF2
GH02G232444 1 Ensembl ENCODE 0.4 -11.6 -11572 0.3 BCOR CTCF ZMYM3 MAX SIN3A ZIC2 HIC1 ZNF316 ZNF143 FOS DIS3L2P1 ALPI
GH02G232454 0.4 ENCODE 0.7 -0.3 -270 2.2 ATF2 ECEL1 ALPI DIS3L2P1
GH02G232446 0.7 ENCODE 0.4 -8.5 -8497 2.0 CTCF PKNOX1 TAF1 MAX ZNF48 EP300 RAD21 NR2F2 GABPA YY1 ECEL1 DIS3L2P1 ALPI
GH02G232443 0.4 ENCODE 0.4 -12.2 -12247 0.2 NR2F6 DIS3L2P1 ALPI
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ALPI on UCSC Golden Path with GeneCards custom track

Genomic Location for ALPI Gene

Chromosome:
2
Start:
232,456,112 bp from pter
End:
232,460,745 bp from pter
Size:
4,634 bases
Orientation:
Plus strand

Genomic View for ALPI Gene

Genes around ALPI on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ALPI Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ALPI Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ALPI Gene

Proteins for ALPI Gene

  • Protein details for ALPI Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P09923-PPBI_HUMAN
    Recommended name:
    Intestinal-type alkaline phosphatase
    Protein Accession:
    P09923
    Secondary Accessions:
    • B2R7Y4
    • Q53S80
    • Q9UBV5
    • Q9UCL2

    Protein attributes for ALPI Gene

    Size:
    528 amino acids
    Molecular mass:
    56812 Da
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Cofactor:
    Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
    Quaternary structure:
    • Homodimer.
    Miscellaneous:
    • In most mammals there are four different isozymes: placental, placental-like, intestinal and tissue non-specific (liver/bone/kidney).

neXtProt entry for ALPI Gene

Selected DME Specific Peptides for ALPI Gene

P09923:
  • VPLSSETH
  • VTADHSHVF
  • GTPDPEYP
  • GVVTTTR
  • GGGRKYM
  • LMGLFEP
  • SAAARFNQCN
  • ETHGGEDVA
  • TATAYLCGVK
  • FARGPQAHL
  • TTRGNEV
  • VEGGRID
  • ALTEAVMFD
  • LAMDRFP
  • GLFEPGD
  • TVTATRILKGQ
  • NLVQEWL
  • LGPETPLAMD
  • LYGNGPGY

Post-translational modifications for ALPI Gene

  • Glycosylation at posLast=141141, posLast=268268, and posLast=429429
  • Modification sites at PhosphoSitePlus

Other Protein References for ALPI Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • R&D Systems Antibodies for ALPI (Alkaline Phosphatase/ALPI)

Domains & Families for ALPI Gene

Gene Families for ALPI Gene

Suggested Antigen Peptide Sequences for ALPI Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P09923

UniProtKB/Swiss-Prot:

PPBI_HUMAN :
  • Belongs to the alkaline phosphatase family.
Family:
  • Belongs to the alkaline phosphatase family.
genes like me logo Genes that share domains with ALPI: view

Function for ALPI Gene

Molecular function for ALPI Gene

GENATLAS Biochemistry:
phosphatase alkaline,intestinal
UniProtKB/Swiss-Prot CatalyticActivity:
A phosphate monoester + H(2)O = an alcohol + phosphate.

Enzyme Numbers (IUBMB) for ALPI Gene

Gene Ontology (GO) - Molecular Function for ALPI Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000287 magnesium ion binding ISS --
GO:0002020 protease binding IPI 18307834
GO:0003824 catalytic activity IEA --
GO:0004035 alkaline phosphatase activity TAS --
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with ALPI: view
genes like me logo Genes that share phenotypes with ALPI: view

Animal Models for ALPI Gene

MGI Knock Outs for ALPI:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ALPI Gene

Localization for ALPI Gene

Subcellular locations from UniProtKB/Swiss-Prot for ALPI Gene

Cell membrane; Lipid-anchor, GPI-anchor.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ALPI gene
Compartment Confidence
plasma membrane 5
extracellular 5
mitochondrion 1
endoplasmic reticulum 1
lysosome 1

Gene Ontology (GO) - Cellular Components for ALPI Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0031225 anchored component of membrane IEA --
genes like me logo Genes that share ontologies with ALPI: view

Pathways & Interactions for ALPI Gene

genes like me logo Genes that share pathways with ALPI: view

Pathways by source for ALPI Gene

Gene Ontology (GO) - Biological Process for ALPI Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006501 C-terminal protein lipidation TAS --
GO:0006654 phosphatidic acid biosynthetic process TAS --
GO:0007586 digestion TAS --
GO:0008152 metabolic process IEA --
GO:0016311 dephosphorylation ISS --
genes like me logo Genes that share ontologies with ALPI: view

No data available for SIGNOR curated interactions for ALPI Gene

Drugs & Compounds for ALPI Gene

(20) Drugs for ALPI Gene - From: DrugBank, ApexBio, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Monopotassium phosphate Approved, Vet_approved Pharma Enzyme, cofactor 0
Sodium monofluorophosphate Approved Pharma Pyruvate/alkaline phosphatase inhibitor 0
Isopropyl alcohol Approved Pharma 0
Phosphoric acid Approved Pharma 0
Water Approved Pharma 0

(29) Additional Compounds for ALPI Gene - From: Novoseek and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
1-Butanol
  • 1-Butanol
  • 1-Butyl alcohol
  • Butanol
  • Butyl alcohol
  • Butyl hydroxide
71-36-3
1-Hexanol
  • 1-Hexanol
  • 1-Hexyl alcohol
  • 1-Hydroxyhexane
  • Alcohol C-6
  • Alcohol(C6)
111-27-3
1-Pentanol
  • 1-Pentanol
  • 1-Pentol
  • 1-Pentyl alcohol
  • Alcool amylique
  • Alcool amylique (french)
71-41-0
dihydroneopterin triphosphate
  • 2-Amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl) dihydropteridine triphosphate
  • 6-(L-Erythro-1,2-Dihydroxypropyl 3-triphosphate)-7,8-dihydropterin
  • 6-[(1S,2R)-1,2-Dihydroxy-3-triphosphooxypropyl]-7,8-dihydropterin
  • 7,8-Dihydroneopterin 3'-triphosphate
  • 7,8-Dihydroneopterin triphosphate
20574-65-6
Isobutanol
  • 1-Hydroxymethylpropane
  • 2-Methyl propanol
  • 2-Methyl-1-propanol
  • 2-Methyl-1-propanyl alcohol
  • 2-Methylpropan-1-ol
78-83-1

(2) ApexBio Compounds for ALPI Gene

Compound Action Cas Number
(-)-p-Bromotetramisole Oxalate 62284-79-1
Sodium Monofluorophosphate Pyruvate/alkaline phosphatase inhibitor 10163-15-2
genes like me logo Genes that share compounds with ALPI: view

Drug Products

Transcripts for ALPI Gene

mRNA/cDNA for ALPI Gene

(1) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(10) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ALPI Gene

Alkaline phosphatase, intestinal:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ALPI Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7
SP1:
SP2:
SP3:

Relevant External Links for ALPI Gene

GeneLoc Exon Structure for
ALPI
ECgene alternative splicing isoforms for
ALPI

Expression for ALPI Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ALPI Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ALPI Gene

This gene is overexpressed in Small Intestine - Terminal Ileum (x46.8) and Colon - Transverse (x4.7).

Protein differential expression in normal tissues from HIPED for ALPI Gene

This gene is overexpressed in Pancreatic juice (66.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ALPI Gene



Protein tissue co-expression partners for ALPI Gene

NURSA nuclear receptor signaling pathways regulating expression of ALPI Gene:

ALPI

SOURCE GeneReport for Unigene cluster for ALPI Gene:

Hs.37009

Evidence on tissue expression from TISSUES for ALPI Gene

  • Intestine(2.7)
  • Liver(2.5)
genes like me logo Genes that share expression patterns with ALPI: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ALPI Gene

Orthologs for ALPI Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for ALPI Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ALPI 34 35
  • 99.18 (n)
dog
(Canis familiaris)
Mammalia ALPP 34
  • 84.71 (n)
-- 35
  • 77 (a)
OneToMany
cow
(Bos Taurus)
Mammalia LOC100125266 34
  • 81.77 (n)
-- 35
  • 77 (a)
ManyToMany
-- 35
  • 77 (a)
ManyToMany
-- 35
  • 76 (a)
ManyToMany
-- 35
  • 75 (a)
ManyToMany
mouse
(Mus musculus)
Mammalia Akp3 34 16 35
  • 80.39 (n)
Alppl2 35
  • 75 (a)
ManyToMany
Alpi 35
  • 72 (a)
ManyToMany
rat
(Rattus norvegicus)
Mammalia Akp3 34
  • 79.35 (n)
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 74 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 74 (a)
OneToMany
chicken
(Gallus gallus)
Aves ALPP 34
  • 71.05 (n)
-- 35
  • 67 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 63 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia alpi.1 34
  • 63.5 (n)
zebrafish
(Danio rerio)
Actinopterygii alpi.2 34
  • 62.15 (n)
alpi.1 35
  • 58 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CG10827 36 34 35
  • 54.77 (n)
Aph-4 36 35
  • 43 (a)
CG1809 36 35
  • 43 (a)
CG5656 36 35
  • 43 (a)
CG10592 36 35
  • 42 (a)
CG3264 36 35
  • 41 (a)
CG3290 36 35
  • 41 (a)
CG5150 36 35
  • 41 (a)
CG3292 36 35
  • 39 (a)
CG16771 36 35
  • 37 (a)
CG8105 36 35
  • 37 (a)
CG8147 35
  • 34 (a)
ManyToMany
CG5361 35
  • 22 (a)
ManyToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP011302 34
  • 54.14 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes PHO8 35
  • 21 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 41 (a)
ManyToMany
-- 35
  • 40 (a)
ManyToMany
-- 35
  • 38 (a)
ManyToMany
CSA.180 35
  • 37 (a)
ManyToMany
CSA.4362 35
  • 37 (a)
ManyToMany
Species where no ortholog for ALPI was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ALPI Gene

ENSEMBL:
Gene Tree for ALPI (if available)
TreeFam:
Gene Tree for ALPI (if available)

Paralogs for ALPI Gene

Paralogs for ALPI Gene

(3) SIMAP similar genes for ALPI Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with ALPI: view

Variants for ALPI Gene

Sequence variations from dbSNP and Humsavar for ALPI Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs1000641323 -- 232,460,134(+) AGATG(A/G)TTGAG utr-variant-3-prime
rs1000844879 -- 232,457,372(+) TGGCA(C/T)AGGCT intron-variant
rs1001975867 -- 232,455,605(+) AACTC(C/T)TTATC upstream-variant-2KB
rs1002881305 -- 232,460,453(+) GGCTC(A/C)GGTGA utr-variant-3-prime
rs1003171992 -- 232,454,159(+) GTAGG(A/G)CCTCT upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for ALPI Gene

Variant ID Type Subtype PubMed ID
dgv160n111 CNV duplication 26073780
dgv494n27 CNV gain 19166990
dgv7336n54 CNV gain 21841781
nsv482060 CNV gain 20164927
nsv522450 CNV loss 19592680
nsv527789 CNV loss 19592680
nsv821918 CNV gain 20364138

Variation tolerance for ALPI Gene

Residual Variation Intolerance Score: 90.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.76; 47.08% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ALPI Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ALPI

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ALPI Gene

Disorders for ALPI Gene

MalaCards: The human disease database

(1) MalaCards diseases for ALPI Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
testis seminoma
  • seminoma
- elite association - COSMIC cancer census association via MalaCards
Search ALPI in MalaCards View complete list of genes associated with diseases

Relevant External Links for ALPI

Genetic Association Database (GAD)
ALPI
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ALPI
genes like me logo Genes that share disorders with ALPI: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ALPI Gene

Publications for ALPI Gene

  1. Chemical nature of intestinal-type alkaline phosphatase in human kidney. (PMID: 1458595) Nishihara Y. … Hirano K. (Clin. Chem. 1992) 3 4 22 64
  2. Cloning and sequencing of human intestinal alkaline phosphatase cDNA. (PMID: 3468508) Berger J. … Udenfriend S. (Proc. Natl. Acad. Sci. U.S.A. 1987) 2 3 4 64
  3. Nucleotide and amino acid sequences of human intestinal alkaline phosphatase: close homology to placental alkaline phosphatase. (PMID: 3469665) Henthorn P.S. … Harris H. (Proc. Natl. Acad. Sci. U.S.A. 1987) 2 3 4 64
  4. Intestinal alkaline phosphatase is a gut mucosal defense factor maintained by enteral nutrition. (PMID: 18292227) Goldberg R.F. … Hodin R.A. (Proc. Natl. Acad. Sci. U.S.A. 2008) 3 22 64
  5. Cathepsin C propeptide interacts with intestinal alkaline phosphatase and heat shock cognate protein 70 in human Caco-2 cells. (PMID: 18307834) Hirasaka K. … Nikawa T. (J Physiol Sci 2008) 3 22 64

Products for ALPI Gene

Sources for ALPI Gene

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