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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ALPI Gene

protein-coding   GIFtS: 66
GCID: GC02P233320

alkaline phosphatase, intestinal
 Explore 26 diseases affiliated with
ALPI via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for ALPI    

Aliases
for ALPI gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Alkaline Phosphatase, Intestinal1 2     Alkaline Phosphomonoesterase2
Intestinal Alkaline Phosphatase2 3     Glycerophosphatase1
IAP2 3     Intestinal-Type Alkaline Phosphatase2
EC 3.1.3.13 8     Kasahara Isozyme2

External Ids:    HGNC: 4371   Entrez Gene: 2482   Ensembl: ENSG000001632957   OMIM: 1717405   UniProtKB: P099233   

Export aliases for ALPI gene to outside databases

Previous GC identifers: GC02P231377 GC02P232050 GC02P233284 GC02P233523 GC02P233146 GC02P233029 GC02P225171


Summaries
for ALPI gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for ALPI:
There are at least four distinct but related alkaline phosphatases: intestinal, placental, placental-like, and
liver/bone/kidney (tissue non-specific). The intestinal alkaline phosphatase gene encodes a digestive brush-border
enzyme. This enzyme is upregulated during small intestinal epithelial cell differentiation. (provided by RefSeq, Jul
2008)

Gene Wiki entry for ALPI


Genomic Views
for ALPI gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000002.11  NC_018913.1  NT_005403.17  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ALPI gene promoter:
         AhR   Pax-5   NCX/Ncx   C/EBPalpha   Evi-1   Arnt   GATA-1   Meis-1b   Meis-1a   Meis-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: ALPI promoter sequence
   Search SABiosciences Chromatin IP Primers for ALPI

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ALPI


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q37.1   Ensembl cytogenetic band:  2q37.1   HGNC cytogenetic band: 2q37.1

ALPI Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ALPI gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02P233320:  view genomic region     (about GC identifiers)

Start:
 233,320,833 bp from pter      End:
 233,324,742 bp from pter
Size:
 3,910 bases      Orientation:
 plus strand

Proteins
for ALPI gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: PPBI_HUMAN, P09923 (See protein sequence)
Recommended Name: Intestinal-type alkaline phosphatase precursor  
Size: 528 amino acids; 56812 Da
Cofactor: Binds 1 magnesium ion (By similarity)
Cofactor: Binds 2 zinc ions (By similarity)
Subunit: Homodimer
Subcellular location: Cell membrane; Lipid-anchor, GPI-anchor
Miscellaneous: In most mammals there are four different isozymes: placental, placental-like, intestinal and tissue
non-specific (liver/bone/kidney)
Secondary accessions: B2R7Y4 Q53S80 Q9UBV5 Q9UCL2

Explore the universe of human proteins at neXtProt for ALPI: NX_P09923

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P09923

    • 4/19 DME Specific Peptides for ALPI (P09923) (see all 19)
     TTRGNEV  VEGGRID  NLVQEWL  GVVTTTR 

    ALPI Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_001622.2  
    ENSEMBL proteins: 
     ENSP00000295463   ENSP00000413068  

    Human Recombinant Protein Products: 
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    Novus Biologicals ALPI Protein
    Novus Biologicals ALPI Lysate
    Browse Sino Biological Recombinant Proteins
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    Uscn Proteins for ALPI

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane IEA--
    GO:0016020membrane NAS--
    GO:0016021integral to membrane IEA--
    GO:0031225anchored to membrane IEA--


    ALPI for ontologies           About GeneDecksing



    ALPI Antibody Products: 
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    Uscn ELISAs and CLIAs for ALPI

    Protein Domains /
    Families
    for ALPI gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    ALPI for domains           About GeneDecksing

    4 InterPro domains/families:
     IPR001952 Alkaline_phosphatase
     IPR017849 Alkaline_Pase-like_a/b/a
     IPR017850 Alkaline_phosphatase_core
     IPR018299 Alkaline_phosphatase_AS

    Graphical View of Domain Structure for InterPro Entry P09923

    ProtoNet protein and cluster: P09923

    1 Blocks protein family: IPB001952 Alkaline phosphatase

    UniProtKB/Swiss-Prot: PPBI_HUMAN, P09923
    Similarity: Belongs to the alkaline phosphatase family


    Function
    for ALPI gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: PPBI_HUMAN, P09923
    Catalytic activity: A phosphate monoester + H(2)O = an alcohol + phosphate

         Genatlas biochemistry entry for ALPI:
    phosphatase alkaline,intestinal

    Enzyme Number (IUBMB): EC 3.1.3.11 2

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ALPI
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    SwitchGear 3'UTR luciferase reporter plasmid: ALPI 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ALPI (see all 7)
    OriGene shRNA RFP: ALPI
    OriGene siRNA: ALPI
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ALPI

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for ALPI

    Clone
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ALPI 

    Cell Line
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    Search LifeMap BioReagents cell lines for ALPI

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ALPI

    Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004035alkaline phosphatase activity NAS2841341
    GO:0046872metal ion binding IEA--


    ALPI for ontologies           About GeneDecksing


    1 GenomeRNAi human phenotype for ALPI:
     Decreased focal adhesion (FA)  


    Pathways & Interactions
    for ALPI gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1NAD metabolism
    		NAD metabolism1.00
    		NAD metabolism1.00
    2Folate biosynthesis
    		Folate biosynthesis1.00
    3Metabolism
    		Metabolic pathways0.38

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    1 EMD Millipore Pathway for ALPI
        NAD metabolism


    1 GeneGo (Thomson Reuters) Pathway for ALPI
        NAD metabolism


    2         Kegg Pathways  (Kegg details for ALPI):
        Folate biosynthesis
    Metabolic pathways


    ALPI for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for ALPI

    STRING Interaction Network Preview (showing 5 interactants - click image to see 6)

    5/6 Interacting proteins for ALPI (P099233 ENSP000002954634) via UniProtKB, MINT, STRING, and/or I2D (see all 6)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    EIF4A2Q142403, ENSP000003263814I2D: score=2 STRING: ENSP00000326381
    BICD1Q96G013, ENSP000002814744I2D: score=1 STRING: ENSP00000281474
    IRF5Q135683, ENSP000003497704I2D: score=1 STRING: ENSP00000349770
    GCH1ENSP000003788904STRING: ENSP00000378890
    PTSENSP000002803624STRING: ENSP00000280362
    About this table

    Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016310phosphorylation NAS--


    ALPI for ontologies           About GeneDecksing



    Drugs & Compounds
    for ALPI gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    ALPI for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ALPI

    10/15 HMDB Compounds for ALPI (see all 15)    About this table
    CompoundSynonyms CAS #PubMed Ids
    1-Butanol1-Butanol (see all 10)71-36-3--
    1-Hexanol1-Hexyl alcohol (see all 30)111-27-3--
    1-Pentanol1-Pentol (see all 34)71-41-0--
    4-Nitrophenol1-Hydroxy-4-nitrobenzene (see all 8)100-02-7--
    7,8-Dihydroneopterin2-Amino-4-hydroxy-6-(D-erythro-1',2',3'-trihydroxypropyl)-7,8-dihydropteridine (see all 11)1218-98-0--
    Dihydroneopterin triphosphate2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl) dihydropteridine triphosphate (see all 5)20574-65-6--
    Dihydroxyacetone1,3-Dihydroxy-2-propanone (see all 21)96-26-4--
    Dihydroxyacetone phosphate1,3-Dihydroxy-2-propanone phosphate (see all 17)57-04-5--
    Ethanol1-Hydroxyethane (see all 57)64-17-5--
    Isobutanol1-Hydroxymethylpropane (see all 18)78-83-1--
    10/31 Novoseek chemical compound relationships for ALPI gene (see all 31)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    glutathione monoester 76.8 1 11423381 (1)
    p-nitrophenyl phosphate 70.1 1 8174763 (1)
    d,l-buthionine-s,r-sulfoximine 61.1 5 11423381 (4), 8916550 (1)
    butyrate 56.3 8 2328777 (2), 10455897 (1), 15765403 (1), 11313308 (1) (see all 5)
    fosphenytoin 55.1 1 8592691 (1)
    sodium orthovanadate 45.2 1 7929029 (1)
    thiamine pyrophosphate 44.4 1 15802905 (1)
    phosphoethanolamine 36.9 1 8174763 (1)
    phytate 34.8 2 7769385 (1), 1880499 (1)
    zinc 31.6 4 13678301 (2), 12945337 (1)

    Search CenterWatch for drugs/clinical trials and news about ALPI / PPBI 

    Transcripts
    for ALPI gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for ALPI gene: 
    NM_001631.3  

    Unigene Cluster for ALPI:

    Alkaline phosphatase, intestinal
    Hs.37009  [show with all ESTs]
    Unigene Representative Sequence: NM_001631
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000295463(uc002vst.4 uc002vsu.4) ENST00000457560

    miRNA
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    SwitchGear 3'UTR luciferase reporter plasmid: ALPI 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ALPI (see all 7)
    OriGene shRNA RFP: ALPI
    OriGene siRNA: ALPI
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ALPI
    Clone
    Products:             		 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ALPI (see all 3)
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    GenScript: all cDNA clones in your preferred vector: ALPI (NM_001631)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ALPI 
    Primer
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      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ALPI

    Additional cDNA sequence: 

    AK313163.1 BC132678.1 M15694.1 M31008.1 

    2 DOTS entries:

    DT.100681926  DT.95362888 

    10 AceView cDNA sequences:

    AW450908 M21499 M31008 M15694 AH002601 BP382856 NM_001631 BP382969 
    BP383175 AU076770 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for ALPI    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7
    SP1:                                                
    SP2:                                                
    SP3:                                                


    ECgene alternative splicing isoforms for ALPI

    Expression
    for ALPI gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ALPI expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: GGCCCTCCCG

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    ALPI expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    1 LifeMap In Vivo Development Anatomical Compartment/Cell 
    Tissue Anatomical Compartment CellCategory (developmental path)
    KidneyProximal TubuleProximal Tubule CellsKidney
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization
    Stem Cell Differentiation: 1 LifeMap Cell 
    NameCategory
    AS034 (Embryonic Stem Cell)Early Embryo, Inner Cell Mass

    See ALPI Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ALPI

    SOURCE GeneReport for Unigene cluster: Hs.37009
        SABiosciences Expression via Pathway-Focused PCR Array including ALPI: 
              Stem Cells in human mouse rat

    Primer
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    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ALPI

    Orthologs
    for ALPI gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the last universal common ancestor (LUCA).

    Orthologs for ALPI gene from 4/20 species (see all 20)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    lizard
    (Anolis carolinensis)    		 Reptilia --
    		 --
    		 63(a)
    		 1 → many
    		 GL343304.1(677973-694404)
    zebrafish
    (Danio rerio)    		 Actinopterygii alpi.21 alkaline phosphatase, intestinal.2 61.51(n)
    62.89(a)    		   574009  NM_001025188.1  NP_001020359.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta CG18091 , 3 alkaline phosphatase3
    CG18091    		 43(a)
    (best of 11)3
    54.33(n)1
    47.36(a)1    		   45F33
    359811  NM_136652.21  NP_610496.11 
    E. coli
    (Escherichia coli)    		 Gamma proteobacteria phoA6
    		 bacterial alkaline phosphatase
    		 26(a)
    		 1 → many
    		 Chromosome(400971-402386)


    ENSEMBL Gene Tree for ALPI (if available)
    TreeFam Gene Tree for ALPI (if available) 

    Paralogs
    for ALPI gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ALPI gene
    ALPL2  ALPPL22  ALPP2  
    3 SIMAP similar genes for ALPI using alignment to 2 protein entries:     PPBI_HUMAN (see all proteins):
    ALPPL2    ALPP    ALPL

    ALPI for paralogs           About GeneDecksing



    Genomic Variants
    for ALPI gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/174 NCBI SNPs in ALPI are shown (see all 174)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 2 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1497049421,2
    		--233318851(+) GCAGGA/GGTGAG 1 -- us2k10--------
    rs1878838151,2
    		--233318955(+) CTCAGC/TTCACT 1 -- us2k10--------
    rs1925647921,2
    		--233319095(+) AGCCAC/GGATGG 1 -- us2k10--------
    rs1114384271,2
    		--233319134(+) CACCTC/TGGCCT 1 -- us2k11Minor allele frequency- T:0.50CSA 2
    rs1832347201,2
    		--233319224(+) TCTGTC/TAAAAA 1 -- us2k10--------
    rs1881567091,2
    		--233319390(+) TAGAGA/GAAACT 1 -- us2k10--------
    rs1488263341,2
    		--233319400(+) TAAGGA/GGGCAA 1 -- us2k10--------
    rs724821051,2
    		C,--233319499(+) GAGGAC/TCCGGG 1 -- us2k14Minor allele frequency- T:0.05WA NA EA 360
    rs28534111,2
    		F,--233319502(+) GACCCG/AGGAAA 1 -- us2k13Minor allele frequency- A:0.04WA NA EA 358
    rs1470008661,2
    		--233319512(+) AGCTCA/GGCCTG 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for ALPI (233320833 - 233324742 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 1 variation for ALPI
         1 CNV: 53765

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ALPI
    DNA2.0 Custom Variant and Variant Library Synthesis for ALPI

    Disorders / Diseases
    for ALPI gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    ALPI for disorders           About GeneDecksing

    OMIM gene information: 171740    OMIM disorders: --

    20/26 diseases for ALPI (see all 26):    About MalaCards
    angle-closure glaucoma    soft palate cancer    alveolar rhabdomyosarcoma    liver cirrhosis
    waardenburg's syndrome    hypophosphatasia    germinoma    rosacea
    seminoma    glaucoma    rhabdomyosarcoma    colon cancer
    crohn's disease    duodenitis    cervical carcinoma    colon carcinoma
    cervicitis    peritonitis    osteosarcoma    nephropathy

    3 diseases from the University of Copenhagen DISEASES database for ALPI:
    Soft palate cancer     Gastrointestinal system disease     Hypophosphatasia

    10 Novoseek disease relationships for ALPI gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    colon cancer 46.7 2 15774940 (1), 16378595 (1)
    neoplastic transformation 35.4 2 7597142 (1), 8664049 (1)
    microalbuminuria 19.9 1 9816378 (1)
    seminoma 17.5 1 8434423 (1)
    liver cirrhosis 6.4 1 1424160 (1)
    bacterial infections 1.62 5 8811051 (2), 9097906 (2), 7899830 (1)
    inflammatory bowel diseases 0 1 17498884 (1)
    metastasis 0 1 16959714 (1)
    tumors 0 5 8434423 (1), 8946869 (1), 11578255 (1), 12577238 (1) (see all 5)
    cancer 0 2 9548446 (1)


    Export disorders for ALPI gene to outside databases

    Publications
    for ALPI gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ALPI gene, integrated from 9 sources (see all 170):
    (articles sorted by number of sources associating them with ALPI)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning and sequencing of human intestinal alkaline phosphatase cDNA. (PubMed id 3468508)1, 2, 3 Berger J.... Udenfriend S. (1987)
    2. Nucleotide and amino acid sequences of human intestinal alkaline phosphatase: close homology to placental alkaline phosphatase. (PubMed id 3469665)1, 2, 3 Henthorn P.S.... Harris H. (1987)
    3. Chemical nature of intestinal-type alkaline phosphatase in human kidney. (PubMed id 1458595)1, 2, 9 Nishihara Y....Hirano K. (1992)
    4. Sequence and characterization of the human intestinal alkaline phosphatase gene. (PubMed id 2841341)1, 2 Henthorn P.S.... Harris H. (1988)
    5. Promoter structure of the human intestinal alkaline phosphatase gene. (PubMed id 3697102)1, 2 Millan J.L. (1987)
    6. Two gene duplication events in the evolution of the human heat-stable alkaline phosphatases. (PubMed id 3443302)1, 2 Knoll B.J.... Longley M. (1987)
    7. Partial sequencing of human adult, human fetal, and bovine intestinal alkaline phosphatases: comparison with the human placental and liver isozymes. (PubMed id 3458202)1, 2 Hua J.-C.... Udenfriend S. (1986)
    8. Differentiation-dependent activation of the human intestinal alkaline phosphatase promoter by HNF-4 in intestinal cells. (PubMed id 15831710)1, 9 Olsen L....Olsen J. (2005)
    9. Placental and intestinal alkaline phosphatases are receptors for Aeromonas sobria hemolysin. (PubMed id 15715171)1, 9 Wada A....Hirayama T. (2005)
    10. Differential regulation of intestinal alkaline phosphatase gene expression by Cdx1 and Cdx2. (PubMed id 15774940)1, 9 Alkhoury F....Hodin R.A. (2005)

    External Searches for ALPI gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
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    Aliases
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    Genome Databases showing ALPI gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 248 HGNC: 437 AceView: ALPI Ensembl:ENSG00000163295 euGenes: HUgn248
    ECgene: ALPI Kegg: 248 H-InvDB: ALPI

    Other Databases showing ALPI gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing ALPI gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ALPI Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for ALPI Genetics and Cytogenetics in Oncology and Haematology
    Wikipedia http://en.wikipedia.org/wiki/Alkaline_phosphatase

    Intellectual Property
    for ALPI gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for ALPI gene:
    Search GeneIP for patents involving ALPI

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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