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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ALPI Gene

protein-coding   GIFtS: 67
GCID: GC02P233320

Alkaline Phosphatase, Intestinal

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Alkaline Phosphatase, Intestinal1 2     Alkaline Phosphomonoesterase2
Intestinal Alkaline Phosphatase2 3     glycerophosphatase2
IAP2 3     Intestinal-Type Alkaline Phosphatase2
EC 3.1.3.13 8     Kasahara Isozyme2

External Ids:    HGNC: 4371   Entrez Gene: 2482   Ensembl: ENSG000001632957   OMIM: 1717405   UniProtKB: P099233   

Export aliases for ALPI gene to outside databases

Previous GC identifers: GC02P231377 GC02P232050 GC02P233284 GC02P233523 GC02P233146 GC02P233029 GC02P225171


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for ALPI Gene:
There are at least four distinct but related alkaline phosphatases: intestinal, placental, placental-like, and
liver/bone/kidney (tissue non-specific). The intestinal alkaline phosphatase gene encodes a digestive
brush-border enzyme. This enzyme is upregulated during small intestinal epithelial cell differentiation.
(provided by RefSeq, Jul 2008)

GeneCards Summary for ALPI Gene: 
ALPI (alkaline phosphatase, intestinal) is a protein-coding gene. Diseases associated with ALPI include soft palate cancer, and gastrointestinal system disease, and among its related super-pathways are Nicotinate and nicotinamide metabolism and Metabolism. GO annotations related to this gene include alkaline phosphatase activity and metal ion binding. An important paralog of this gene is ALPPL2.

Gene Wiki entry for ALPI Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000002.11  NT_005403.17  NC_018913.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ALPI gene promoter:
         AhR   Pax-5   NCX/Ncx   C/EBPalpha   Evi-1   Arnt   GATA-1   Meis-1b   Meis-1a   Meis-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidALPI promoter sequence
   Search SABiosciences Chromatin IP Primers for ALPI

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ALPI


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q37.1   Ensembl cytogenetic band:  2q37.1   HGNC cytogenetic band: 2q37.1

ALPI Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ALPI gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02P233320:  view genomic region     (about GC identifiers)

Start:
233,320,833 bp from pter      End:
233,324,742 bp from pter
Size:
3,910 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: PPBI_HUMAN, P09923 (See protein sequence)
Recommended Name: Intestinal-type alkaline phosphatase precursor  
Size: 528 amino acids; 56812 Da
Cofactor: Binds 1 magnesium ion (By similarity)
Cofactor: Binds 2 zinc ions (By similarity)
Subunit: Homodimer
Subcellular location: Cell membrane; Lipid-anchor, GPI-anchor
Miscellaneous: In most mammals there are four different isozymes: placental, placental-like, intestinal and tissue
non-specific (liver/bone/kidney)
Secondary accessions: B2R7Y4 Q53S80 Q9UBV5 Q9UCL2

Explore the universe of human proteins at neXtProt for ALPI: NX_P09923

Explore proteomics data for ALPI at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P09923

  • 4/19 DME Specific Peptides for ALPI (P09923) (see all 19)
     TTRGNEV  VEGGRID  NLVQEWL  GVVTTTR 

    ALPI Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    ALPI Protein Expression
    REFSEQ proteins: NP_001622.2  
    ENSEMBL proteins: 
     ENSP00000295463   ENSP00000413068  

    Human Recombinant Protein Products for ALPI: 
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    Novus Biologicals ALPI Protein
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    Sino Biological Recombinant Protein for ALPI
    Sino Biological Cell Lysate for ALPI 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for ALPI 

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane IEA--
    GO:0016020membrane NAS--
    GO:0016021integral to membrane IEA--
    GO:0031225anchored to membrane IEA--

    ALPI for ontologies           About GeneDecksing



    ALPI Antibody Products: 
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    Cloud-Clone Corp. ELISAs for ALPI 
    Cloud-Clone Corp. CLIAs for ALPI


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    4 InterPro protein domains:
     IPR001952 Alkaline_phosphatase
     IPR017849 Alkaline_Pase-like_a/b/a
     IPR017850 Alkaline_phosphatase_core
     IPR018299 Alkaline_phosphatase_AS

    Graphical View of Domain Structure for InterPro Entry P09923

    ProtoNet protein and cluster: P09923

    1 Blocks protein domain: IPB001952 Alkaline phosphatase

    UniProtKB/Swiss-Prot: PPBI_HUMAN, P09923
    Similarity: Belongs to the alkaline phosphatase family


    ALPI for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: PPBI_HUMAN, P09923
    Catalytic activity: A phosphate monoester + H(2)O = an alcohol + phosphate

         Genatlas biochemistry entry for ALPI:
    phosphatase alkaline,intestinal

         Enzyme Number (IUBMB): EC 3.1.3.11 2

         Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003824catalytic activity ----
    GO:0004035alkaline phosphatase activity NAS2841341
    GO:0016791phosphatase activity ----
    GO:0046872metal ion binding IEA--
         
    ALPI for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for ALPI:
     Decreased focal adhesion (FA)  

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for ALPI 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for ALPI

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    miRNA
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    Inhib. RNA
    Products:
        
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    Clone
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for ALPI About                                                                                                See pathways by source

    SuperPathContained pathways About
    1NAD metabolism
    NAD metabolism0.43
    2Metabolism
    Metabolic pathways0.40
    3Folate biosynthesis
    Folate biosynthesis

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 EMD Millipore Pathway for ALPI
        NAD metabolism


    1 GeneGo (Thomson Reuters) Pathway for ALPI
        NAD metabolism



    2         Kegg Pathways  (Kegg details for ALPI):
        Folate biosynthesis
    Metabolic pathways


    ALPI for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for ALPI

    STRING Interaction Network Preview (showing 5 interactants - click image to see 6)

    5/6 Interacting proteins for ALPI (P099233 ENSP000002954634) via UniProtKB, MINT, STRING, and/or I2D (see all 6)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    EIF4A2Q142403, ENSP000003263814I2D: score=2 STRING: ENSP00000326381
    BICD1Q96G013, ENSP000002814744I2D: score=1 STRING: ENSP00000281474
    IRF5Q135683, ENSP000003497704I2D: score=1 STRING: ENSP00000349770
    GCH1ENSP000003788904STRING: ENSP00000378890
    PTSENSP000002803624STRING: ENSP00000280362
    About this table

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008152metabolic process ----
    GO:0016310phosphorylation NAS--

    ALPI for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    ALPI for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ALPI (PPBI)

    10/15 HMDB Compounds for ALPI (see all 15)    About this table
    CompoundSynonyms CAS #PubMed Ids
    1-Butanol1-Butanol (see all 10)71-36-3--
    1-Hexanol1-Hexyl alcohol (see all 30)111-27-3--
    1-Pentanol1-Pentol (see all 34)71-41-0--
    4-Nitrophenol1-Hydroxy-4-nitrobenzene (see all 8)100-02-7--
    7,8-Dihydroneopterin2-Amino-4-hydroxy-6-(D-erythro-1',2',3'-trihydroxypropyl)-7,8-dihydropteridine (see all 11)1218-98-0--
    Dihydroneopterin triphosphate2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl) dihydropteridine triphosphate (see all 5)20574-65-6--
    Dihydroxyacetone1,3-Dihydroxy-2-propanone (see all 21)96-26-4--
    Dihydroxyacetone phosphate1,3-Dihydroxy-2-propanone phosphate (see all 17)57-04-5--
    Ethanol1-Hydroxyethane (see all 57)64-17-5--
    Isobutanol1-Hydroxymethylpropane (see all 18)78-83-1--

    10/31 Novoseek inferred chemical compound relationships for ALPI gene (see all 31)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    glutathione monoester 76.8 1 11423381 (1)
    p-nitrophenyl phosphate 70.1 1 8174763 (1)
    d,l-buthionine-s,r-sulfoximine 61.1 5 11423381 (4), 8916550 (1)
    butyrate 56.3 8 2328777 (2), 10455897 (1), 15765403 (1), 11313308 (1) (see all 5)
    fosphenytoin 55.1 1 8592691 (1)
    sodium orthovanadate 45.2 1 7929029 (1)
    thiamine pyrophosphate 44.4 1 15802905 (1)
    phosphoethanolamine 36.9 1 8174763 (1)
    phytate 34.8 2 7769385 (1), 1880499 (1)
    zinc 31.6 4 13678301 (2), 12945337 (1)

    Search CenterWatch for drugs/clinical trials and news about ALPI / PPBI

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for ALPI gene: 
    NM_001631.3  

    Unigene Cluster for ALPI:

    Alkaline phosphatase, intestinal
    Hs.37009  [show with all ESTs]
    Unigene Representative Sequence: NM_001631
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000295463(uc002vst.4 uc002vsu.4) ENST00000457560
    miRNA
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    Inhib. RNA
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    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ALPI
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ALPI
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    Primer
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ALPI
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ALPI

    Additional mRNA sequence: 

    AK313163.1 BC132678.1 M15694.1 M31008.1 

    2 DOTS entries:

    DT.100681926  DT.95362888 

    10 AceView cDNA sequences:

    M21499 AW450908 AH002601 NM_001631 BP382969 M31008 BP382856 M15694 
    BP383175 AU076770 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for ALPI    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7
    SP1:                                                
    SP2:                                                
    SP3:                                                


    ECgene alternative splicing isoforms for ALPI

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ALPI expression in normal human tissues (normalized intensities)      ALPI embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GGCCCTCCCG
    ALPI Expression
    About this image


    ALPI expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/3 selected tissues (see all 3) fully expand
     
     Intestine (Gastrointestinal Tract)
             small intestine   
     
     Inner Cell Mass (Early Embryonic Tissues)
             AS034
     
     Kidney (Urinary System)
             Proximal Tubule Cells Proximal Tubule

    See ALPI Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ALPI

    SOURCE GeneReport for Unigene cluster: Hs.37009
        SABiosciences Expression via Pathway-Focused PCR Array including ALPI: 
              Stem Cells in human mouse rat

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ALPI

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals and fungi.

    Orthologs for ALPI gene from 6/14 species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Alpi5
    Akp31
    alkaline phosphatase, intestinal5
    alkaline phosphatase 3, intestine, not Mn requiring1
    79.24(n)1
    79.62(a)1
      1 (44.05 cM)5
    116481  NM_007432.21  NP_031458.21 
     870980025 
    chicken
    (Gallus gallus)
    Aves --
    --
    --
    67(a)
    57(a)
    1 ↔ many
    possible ortholog
    9(15043911-15046938)
    9(15040804-15043296)
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    (see all 3)
    Alkaline phosphatase
    (see all 3)
    65(a)
    62(a)
    (see all 3)
    possible ortholog
    1 ↔ many
    (see all 3)
    AAWZ02040724(38-6154)
    GL343304.1(677973-694404)
    zebrafish
    (Danio rerio)
    Actinopterygii alpi.21 alkaline phosphatase, intestinal.2 61.51(n)
    62.89(a)
      574009  NM_001025188.1  NP_001020359.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG18091 , 3 alkaline phosphatase3
    CG18091
    43(a)
    (best of 11)3
    54.33(n)1
    47.36(a)1
      45F33
    359811  NM_136652.21  NP_610496.11 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes PHO86
    Repressible vacuolar alkaline phosphatase; regulat...
    17(a)
    1 → many
    IV(1418550-1420250)


    ENSEMBL Gene Tree for ALPI (if available)
    TreeFam Gene Tree for ALPI (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ALPI gene
    ALPPL22  ALPL2  ALPP2  
    3 SIMAP similar genes for ALPI using alignment to 2 protein entries:     PPBI_HUMAN (see all proteins):
    ALPPL2    ALPP    ALPL

    ALPI for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/256 SNPs in ALPI are shown (see all 256)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1497049421,2
    --233318851(+) GCAGGA/GGTGAG 1 -- us2k10--------
    rs1878838151,2
    --233318955(+) CTCAGC/TTCACT 1 -- us2k10--------
    rs1925647921,2
    --233319095(+) AGCCAC/GGATGG 1 -- us2k10--------
    rs1114384271,2
    F--233319134(+) CACCTC/TGGCCT 1 -- us2k11Minor allele frequency- T:0.50CSA 2
    rs1832347201,2
    --233319224(+) TCTGTC/TAAAAA 1 -- us2k10--------
    rs1881567091,2
    --233319390(+) TAGAGA/GAAACT 1 -- us2k10--------
    rs1488263341,2
    --233319400(+) TAAGGA/GGGCAA 1 -- us2k10--------
    rs724821051,2
    C--233319499(+) GAGGAC/TCCGGG 1 -- us2k14Minor allele frequency- T:0.05WA NA EA 360
    rs28534111,2
    C,F--233319502(+) GACCCG/AGGAAA 1 -- us2k13Minor allele frequency- A:0.04WA NA EA 358
    rs1470008661,2
    C--233319512(+) AGCTCA/GGCCTG 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for ALPI (233320833 - 233324742 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10/12 variations for ALPI (see all 12):    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv527789CNV Loss19592680
    nsv875977CNV Loss21882294
    nsv875998CNV Loss21882294
    nsv522450CNV Loss19592680
    nsv875999CNV Loss21882294
    dgv4450n71CNV Loss21882294
    nsv482060CNV Gain20164927
    nsv821918CNV Gain20364138
    dgv4449n71CNV Gain21882294
    dgv494n27CNV Gain19166990

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 171740    OMIM disorders: --

    20/23 diseases for ALPI (see all 23):    About MalaCards
    soft palate cancer    gastrointestinal system disease    rosacea    seminoma
    hypophosphatasia    alveolar rhabdomyosarcoma    germinoma    waardenburg's syndrome
    liver cirrhosis    rhabdomyosarcoma    duodenitis    peritonitis
    colon cancer    crohn's disease    glaucoma    inflammatory bowel disease
    osteosarcoma    alcoholism    obesity    cervicitis

    2 diseases from the University of Copenhagen DISEASES database for ALPI:
    Soft palate cancer     Gastrointestinal system disease

    ALPI for disorders           About GeneDecksing

    10 Novoseek inferred disease relationships for ALPI gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    colon cancer 46.7 2 15774940 (1), 16378595 (1)
    neoplastic transformation 35.4 2 7597142 (1), 8664049 (1)
    microalbuminuria 19.9 1 9816378 (1)
    seminoma 17.5 1 8434423 (1)
    liver cirrhosis 6.4 1 1424160 (1)
    bacterial infections 1.62 5 8811051 (2), 9097906 (2), 7899830 (1)
    inflammatory bowel diseases 0 1 17498884 (1)
    metastasis 0 1 16959714 (1)
    tumors 0 5 8434423 (1), 8946869 (1), 11578255 (1), 12577238 (1) (see all 5)
    cancer 0 2 9548446 (1)

    Genetic Association Database (GAD): ALPI

    Export disorders for ALPI gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ALPI gene, integrated from 9 sources (see all 171):
    (articles sorted by number of sources associating them with ALPI)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning and sequencing of human intestinal alkaline phosphatase cDNA. (PubMed id 3468508)1, 2, 3 Berger J.... Udenfriend S. (1987)
    2. Nucleotide and amino acid sequences of human intestinal alkaline phosphatase: close homology to placental alkaline phosphatase. (PubMed id 3469665)1, 2, 3 Henthorn P.S.... Harris H. (1987)
    3. Chemical nature of intestinal-type alkaline phosphatase in human kidney. (PubMed id 1458595)1, 2, 9 Nishihara Y....Hirano K. (1992)
    4. Sequence and characterization of the human intestinal alkaline phosphatase gene. (PubMed id 2841341)1, 2 Henthorn P.S.... Harris H. (1988)
    5. Promoter structure of the human intestinal alkaline phosphatase gene. (PubMed id 3697102)1, 2 Millan J.L. (1987)
    6. Two gene duplication events in the evolution of the human heat-stable alkaline phosphatases. (PubMed id 3443302)1, 2 Knoll B.J.... Longley M. (1987)
    7. Partial sequencing of human adult, human fetal, and bovine intestinal alkaline phosphatases: comparison with the human placental and liver isozymes. (PubMed id 3458202)1, 2 Hua J.-C.... Udenfriend S. (1986)
    8. Differentiation-dependent activation of the human intestinal alkaline phosphatase promoter by HNF-4 in intestinal cells. (PubMed id 15831710)1, 9 Olsen L....Olsen J. (2005)
    9. Placental and intestinal alkaline phosphatases are receptors for Aeromonas sobria hemolysin. (PubMed id 15715171)1, 9 Wada A....Hirayama T. (2005)
    10. Differential regulation of intestinal alkaline phosphatase gene expression by Cdx1 and Cdx2. (PubMed id 15774940)1, 9 Alkhoury F....Hodin R.A. (2005)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
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      Query String
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    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 248 HGNC: 437 AceView: ALPI Ensembl:ENSG00000163295 euGenes: HUgn248
    ECgene: ALPI Kegg: 248 H-InvDB: ALPI

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ALPI Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for ALPI Genetics and Cytogenetics in Oncology and Haematology
    Wikipedia http://en.wikipedia.org/wiki/Alkaline_phosphatase

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for ALPI gene:
    Search GeneIP for patents involving ALPI

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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