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Aliases & Descriptions for ALPI
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase) About This Section
|
| Aliases |
|---|
| EC 3.1.3.1 3 | | IAP 2, 3 | | glycerophosphatase 2 |
| | | Descriptions |
|---|
| Kasahara isozyme 2 | | alkaline phosphatase, intestinal 2 | | alkaline phosphomonoesterase 2 | | intestinal alkaline phosphatase 2 |
|
| | Search outside databases for aliases for ALPI genePrevious GC identifers: GC02P231377 GC02P232050 GC02P233284 GC02P233523 GC02P233146 |
Summaries for ALPI(According to Entrez Gene,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| EntrezGene summary for ALPI: There are at least four distinct but related alkaline phosphatases: intestinal, placental, placental-like, and liver/bone/kidney (tissue non-specific). The intestinal alkaline phosphatase gene encodes a digestive brush-border enzyme. This enzyme is upregulated during small intestinal epithelial cell differentiation. [provided by RefSeq]
|
Genomic Location for ALPI
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to
UCSC and
Ensembl,
Transcription factor binding sites according to
SABiosciences) About This Section
| Genomic View: UCSC Golden Path with GeneCards custom track
Transcription factor binding sites upstream to the ALPI gene 
Entrez Gene cytogenetic band: 2q37.1 Ensembl cytogenetic band: 2q37.1 HGNC cytogenetic band: 2q37.1ALPI Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)
 GeneLoc gene densities for chromosome 2 GeneLoc Exon Structure GeneLoc location for GC02P233029:
(about GC identifiers)
Start:
|
233,029,077 bp from pter |
End:
|
233,032,986 bp from pter |
Size:
|
3,910 bases |
Orientation:
|
plus strand |
RefSeq DNA sequence:- NC_000002.10 NT_005403.16
| Proteins for ALPI
(According to
1UniProtKB,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Enzo Life Sciences,
Abnova,
OriGene and/or,
Abcam,
Biochemical Assays by
Invitrogen,
Millipore,
R&D Systems,
Cell Signaling Technology, and/or
Enzo Life Sciences,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene,
Antibodies by Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Cell Signaling Technology,
Abcam,
Abnova, and/or
Novus Biologicals)
About This Section
| UniProtKB/Swiss-Prot: PPBI_HUMAN, P09923 (See
protein sequence)Recommended Name: Intestinal alkaline phosphatase precursor Size: 528 amino acids; 56812 Da
Cofactor: Binds 1 magnesium ion (By similarity)
Cofactor: Binds 2 zinc ions (By similarity)
Subunit: Homodimer
Subcellular location: Cell membrane; Lipid-anchor, GPI-anchor
Miscellaneous: In most mammals there are four different isozymes: placental, placental-like, intestinal and tissue non-specific (liver/bone/kidney)
Secondary accessions: Q53S80 Q9UBV5 Q9UCL2Post-translational modifications:
View phosphorylation sites using PhosphoSite2
REFSEQ proteins: NP_001622.2
ENSEMBL proteins: ENSP00000295463
Human Recombinant Proteins Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 
3 Gene Ontology (GO) cellular component terms (links to tree view): About this table
Antibodies for ALPI: Assays for ALPI: | Protein
Domains/ Families for ALPI(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| - Graphical View of Domain Structure for InterPro Entry P09923
ProtoNet protein and cluster: P09923 1 Blocks protein family: IPB001952 Alkaline phosphatase
UniProtKB/Swiss-Prot: PPBI_HUMAN, P09923Similarity: Belongs to the alkaline phosphatase family | Gene Function for ALPI
(According to MGI Jun 06 2009, UniProtKB,
IUBMB,and/or Genatlas,
shRNA from
OriGene,
Sigma-Aldrich, RNAi from
Sigma-Aldrich,
RNAi Products,
Clones, and
Q-PCR Products
from Invitrogen,
Millipore,
OriGene, and/or
Abnova,
siRNAs from
Applied Biosystems,
SYBR primers from OriGene,
Cell-based Assays from Millipore,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_001631
Applied Biosystems Silencer® siRNAs for ALPI
Sigma-Aldrich siRNA and siRNA Panels for ALPI  Sigma-Aldrich shRNA for ALPI  Explore Sigma-Aldrich super-pooled esiRNAs 
              OriGene GFP tagged cDNA clone in CMV expression vector: NM_001631                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_001631                                  untagged cDNA clone in CMV expression vector: NM_001631 
Primers: Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers               OriGene genome-wide validated SYBR primer pairs: NM_001631
UniProtKB/Swiss-Prot: PPBI_HUMAN, P09923Catalytic activity: A phosphate monoester + H(2)O = an alcohol + phosphateEnzyme Number (IUBMB): EC 3.1.3.1 Genatlas biochemistry entry for ALPI:phosphatase alkaline,intestinal5 Gene Ontology (GO) molecular function terms (links to tree view): About this table | Pathways & Interactions for ALPI
(Pathways according to Invitrogen
(maps by GeneGo),
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Proteins Network according to
SABiosciences,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|
1 Sigma-Aldrich "Your Favorite Gene" Pathway for ALPI (Your Favorite Gene powered by Ingenuity) 
Gene Network CentralTM Interacting Genes and Proteins Network for ALPI 
5/72 Interacting proteins for ALPI (P099231 ENSP000002954633) via UniProtKB, MINT, and/or STRING (see all 72
)About this table
2 Gene Ontology (GO) biological process terms (links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0008152 | metabolic process |
IEA | -- | | GO:0016310 | phosphorylation |
NAS | -- | About this table
|
Drugs & Compounds for ALPI(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
Browse Tocris compounds for ALPI 10/23 Novoseek chemical compound relationships for ALPI gene (see all 23
)
About this table
|
Transcripts for ALPI(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from Invitrogen,
Millipore, and/or
Abnova,
siRNAs from Applied Biosystems,
Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
Tagged/untagged cDNA clones from
OriGene, Expression Assays from Applied Biosystems) About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_001631
Sigma-Aldrich siRNA and siRNA Panels for ALPI  Sigma-Aldrich shRNA for ALPI  Explore Sigma-Aldrich super-pooled esiRNAs 
Applied Biosystems Silencer® siRNAs: NM_001631 REFSEQ mRNAs for ALPI gene: NM_001631.3
Applied Biosystems TaqMan ® Gene Expression Assays: NM_001631               OriGene GFP tagged cDNA clone in CMV expression vector: NM_001631                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_001631                                  untagged cDNA clone in CMV expression vector: NM_001631  Additional cDNA sequence: AK313163.1 BC132678.1 M15694.1 M31008.1 2 DOTS entries: DT.100681926 DT.95362888 10 AceView cDNA sequences:AW450908 M21499 M15694 BP382856 NM_001631 AH002601 BP382969 M31008 BP383175 AU076770
highest scoring ESTs for ALPI:M15694 M31008 AA098937 AA179477 AA179533 AA190871 NM_001631 AA179501 AA190964 AU076770 Unigene Cluster for ALPI: Alkaline phosphatase, intestinal Hs.37009 [show with all ESTs]Unigene Representative Sequence: NM_001631
GeneLoc Exon Structure
3 Alternative Splicing Database (ASD) splice patterns (SP) for ALPI
| ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4a | · | 4b | ^ | 5 | ^ | 6 | ^ | 7 | |
| SP1: | |   | |   | |   | |   | |   | |   | |   | |   | |
| SP2: | |   | |   | |   | |   | |   | |   | |   | |   | |
| SP3: | |   | |   | |   | |   | |   | |   | |   | |   |
About this scheme
ECgene alternative splicing isoforms for ALPI
1 Ensembl transcript including schematic representation: ENST00000295463
|
Expression for ALPI
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Expression Assays from
Applied Biosystems
)
About This Section
| ALPI expression in normal and diseased human tissues
Applied Biosystems TaqMan ® Gene Expression Assays for ALPI
1 / 2 / 3 5 probe-sets matching ALPI gene Data from
(Publications) and GNF BioGPS About these images About these images
CGAP SAGE TAG: GGCCCTCCCG
SOURCE GeneReport for Unigene cluster: Hs.37009
Expression variation in blood from EXPOLDB for ALPI |
Orthologs for ALPI
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for ALPI gene from 5/8 species (see all 8
)
About this table Species with no ortholog for ALPI
ENSEMBL Gene Tree for ALPI | Paralogs for ALPI(Paralogs according to 1HomoloGene and 2Ensembl, Pseudogenes according to 3Pseudogene.org) About This Section
| Paralogs for ALPI gene
- ALPPL22 ALPL2 ALPP2
|
SNPs/Variants for ALPI(According to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Genotyping Reagents from
Applied Biosystems)
About This Section
|
HapMap Linkage Disequilibrium images for ALPI (up to first 250kb)
|
Disorders & Mutations for ALPI
(in which this Gene is Involved, According to
OMIM, UniProtKB,
Novoseek, PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
HGMD, GAD,
HuGE Navigator,
BCGD,
and/or TGDB.)
About This Section
|
OMIM: 171740
10 Novoseek disease relationships for ALPI gene
About this table
|
Medical News for ALPI(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications for ALPI (in
PubMed.
Associations of this gene to articles via
1Novoseek,
2HGNC,
3Entrez Gene,
4UniProtKB/Swiss-Prot,
5UniProtKB/TrEMBL,
6GAD, and/or
7PharmGKB)
About This Section
| 10/152 PubMed articles for ALPI gene (see all 152
):- Cloning and sequencing of human intestinal alkaline phosphatase cDNA. (PubMed id 3468508)2, 3, 4 Berger J.... Udenfriend S. (1987)
- Nucleotide and amino acid sequences of human intestinal alkaline phosphatase: close homology to placental alkaline phosphatase. (PubMed id 3469665)2, 3, 4 Henthorn P.S....Harris H. (1987)
- Chemical nature of intestinal-type alkaline phosphatase in human kidney. (PubMed id 1458595)1, 3, 4 Nishihara Y....Hirano K. (1992)
- Large-scale characterization of HeLa cell nuclear phosphoproteins. (PubMed id 15302935)3, 4 Beausoleil S.A....Gygi S.P. (2004)
- Sequence and characterization of the human intestinal alkaline phosphatase gene. (PubMed id 2841341)3, 4 Henthorn P.S.... Harris H. (1988)
- Promoter structure of the human intestinal alkaline phosphatase gene. (PubMed id 3697102)3, 4 Millan J.L. (1987)
- Two gene duplication events in the evolution of the human heat-stable alkaline phosphatases. (PubMed id 3443302)3, 4 Knoll B.J.... Longley M. (1987)
- Partial sequencing of human adult, human fetal, and bovine intestinal alkaline phosphatases: comparison with the human placental and liver isozymes. (PubMed id 3458202)3, 4 Hua J.-C.... Udenfriend S. (1986)
- Differentiation-dependent activation of the human intestinal alkaline phosphatase promoter by HNF-4 in intestinal cells. (PubMed id 15831710)1, 3 Olsen L....Olsen J. (2005)
- Placental and intestinal alkaline phosphatases are receptors for Aeromonas sobria hemolysin. (PubMed id 15715171)1, 3 Wada A....Hirayama T. (2005)
|
Search for ALPI
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
|
|
Genome Databases showing ALPI
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
and/or
H-InvDB)
About This Section
|
| Other Databases showing ALPI
(According to HUGE)
About This Section
| -- |
Specialized Databases showing ALPI(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
|
| About This Section
| --
| Services for ALPI(Reagents available from Applied Biosystems, Antibodies and assays by Cell
Signaling Technology, Abcam, Novus Biologicals, Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich, Enzo Life Sciences, and/or Tocris Bioscience) About This Section
| 
 Products for ALPI:

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GeneCards Homepage - Last full update: 2 Jul 2009
Incremental update: 13 Oct 2009
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