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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ALOXE3 Gene

protein-coding   GIFtS: 56
GCID: GC17M007999

arachidonate lipoxygenase 3

 Explore 10 diseases affiliated with
ALOXE3 via our new
 Human Malady Compendium 
Biological research products
for ALOXE3
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
Arachidonate Lipoxygenase 31 2     ARCI32
E-LOX1 2     Epidermal Lipoxygenase2
ELOX31     Epidermis-Type Lipoxygenase 32
E-LOX-31     EC 1.13.11.-3

External Ids:    HGNC: 137431   Entrez Gene: 593442   Ensembl: ENSG000001791487   OMIM: 6072065   UniProtKB: Q9BYJ13   

Export aliases for ALOXE3 gene to outside databases

Previous GC identifers: GC17P008434 GC17M009087 GC17M007941 GC17M008199 GC17M007939 GC17M007894


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for ALOXE3:
This gene is a member of the lipoxygenase family, which are catabolized by arachidonic acid-derived compounds. The
encoded enzyme is a hydroperoxide isomerase that synthesizes a unique type of epoxy alcohol
(8R-hydroxy-11R,12R-epoxyeicosa-5Z,9E,14Z-trienoic acid) from 12R-hydroperoxyeicosatetraenoic acid (12R-HPETE). This
epoxy alcohol can activate the the nuclear receptor peroxisome proliferator-activated receptor alpha (PPARalpha),
which is implicated in epidermal differentiation. Loss of function of the enzyme encoded by this gene results in
ichthyosis, implicating the function of this gene in the differentiation of human skin. This gene is part of a cluster
of lipoxygenase genes on 17p13.1. Mutations in this gene result in nonbullous congenital ichthyosiform erythroderma
(NCIE). Multiple transcript variants encoding different isoforms have been found for this gene.(provided by RefSeq,
Sep 2009)

UniProtKB/Swiss-Prot: LOXE3_HUMAN, Q9BYJ1
Function: Introduces molecular oxygen into polyunsaturated fatty acids. Exact substrate is not known

Gene Wiki entry for ALOXE3


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000017.10  NC_018928.1  NT_010718.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ALOXE3 gene promoter:
         Nkx3-1   NF-1/L   NF-1   Nkx3-1 v4   Lmo2   Nkx3-1 v1   LCR-F1   HEN1   Nkx3-1 v2   Nkx3-1 v3   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidALOXE3 promoter sequence
   Search SABiosciences Chromatin IP Primers for ALOXE3

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ALOXE3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17p13.1   Ensembl cytogenetic band:  17p13.1   HGNC cytogenetic band: 17p13.1

ALOXE3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ALOXE3 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17M007999:  view genomic region     (about GC identifiers)

Start:
7,999,218 bp from pter      End:
8,022,365 bp from pter
Size:
23,148 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: LOXE3_HUMAN, Q9BYJ1 (See protein sequence)
Recommended Name: Epidermis-type lipoxygenase 3  
Size: 711 amino acids; 80543 Da
Cofactor: Binds 1 iron ion per subunit (By similarity)
Secondary accessions: B2R981 B7Z3W0 Q3ZB74 Q9H4F2 Q9HC22
Alternative splicing: 2 isoforms:  Q9BYJ1-1   Q9BYJ1-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for ALOXE3: NX_Q9BYJ1

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q9BYJ1

  • ALOXE3 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (2 alternative transcripts): 
    NP_001159432.1  NP_067641.2  

    ENSEMBL proteins: 
     ENSP00000369494   ENSP00000400581   ENSP00000314879  

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    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    ALOXE3 for domains           About GeneDecksing

    5/7 InterPro domains/families (see all 7):
     IPR020833 LipOase_Fe_BS
     IPR013819 LipOase_C
     IPR001024 LipOase_LH2
     IPR008976 Lipase_LipOase
     IPR020834 LipOase_CS

    Graphical View of Domain Structure for InterPro Entry Q9BYJ1

    ProtoNet protein and cluster: Q9BYJ1

    3 Blocks protein families:
    IPB000907 Lipoxygenase
    IPB001024 Lipoxygenase
    IPB001885 Mammalian lipoxygenase signature


    UniProtKB/Swiss-Prot: LOXE3_HUMAN, Q9BYJ1
    Similarity: Belongs to the lipoxygenase family
    Similarity: Contains 1 lipoxygenase domain
    Similarity: Contains 1 PLAT domain


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    Function Summary:

         UniProtKB/Swiss-Prot: LOXE3_HUMAN, Q9BYJ1
    Function: Introduces molecular oxygen into polyunsaturated fatty acids. Exact substrate is not known

    Enzyme Number (IUBMB): EC 1.13.11.-1

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    Inhib. RNA
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    Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005506iron ion binding IEA--
    GO:0016165lipoxygenase activity IEA--


    ALOXE3 for ontologies           About GeneDecksing



    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Synthesis of Prostaglandins (PG) and Thromboxanes (TX)
    Prostaglandin 2 biosynthesis and metabolism FM0.44
    Prostaglandin 2 biosynthesis and metabolism FM0.44

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    1 EMD Millipore Pathway for ALOXE3
        Prostaglandin 2 biosynthesis and metabolism FM


    1 GeneGo (Thomson Reuters) Pathway for ALOXE3
        Prostaglandin 2 biosynthesis and metabolism FM


    UniProtKB/Swiss-Prot: LOXE3_HUMAN, Q9BYJ1
    Pathway: Lipid metabolism; leukotriene D4 biosynthesis


    ALOXE3 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ALOXE3

    STRING Interaction Network Preview (showing 4 interactants - click image to see more details)

    4 Interacting proteins for ALOXE3 (ENSP000003148794) via UniProtKB, MINT, STRING, and/or I2D

    InteractantInteraction Details
    GeneCardExternal ID(s)
    COTL1ENSP000002624284STRING: ENSP00000262428
    ITGB4ENSP000002001814STRING: ENSP00000200181
    KRT5ENSP000002522424STRING: ENSP00000252242
    VPS39ENSP000003265344STRING: ENSP00000326534
    About this table

    Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0019370leukotriene biosynthetic process IEA--


    ALOXE3 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    ALOXE3 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ALOXE3

    1 HMDB Compound for ALOXE3    About this table
    CompoundSynonyms CAS #PubMed Ids
    IronArmco iron (see all 19)7439-89-6--
    3 Novoseek chemical compound relationships for ALOXE3 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    12(r)-hpete 97.8 4 15629692 (1), 18086569 (1), 17045234 (1)
    arachidonic acid 55.6 5 10569809 (1), 17608720 (1), 17436029 (1)
    lipid 10.2 1 18341575 (1)

    Search CenterWatch for drugs/clinical trials and news about ALOXE3 / LOXE3 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for ALOXE3 gene (2 alternative transcripts): 
    NM_001165960.1  NM_021628.2  

    Unigene Cluster for ALOXE3:

    Arachidonate lipoxygenase 3
    Hs.232770  [show with all ESTs]
    Unigene Representative Sequence: NM_001165960
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000380149(uc002gka.3 uc010vuo.2) ENST00000448843(uc010cnr.3)
    ENST00000583808 ENST00000318227(uc010vup.2)

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    hsa-miR-525-5p hsa-miR-520a-5p hsa-miR-3667-3p
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    Inhib. RNA
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ALOXE3
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    Additional cDNA sequence: 

    AF182218.1 AJ269499.1 AK292732.1 AK296416.1 AK313677.1 BC101938.1 BC101939.1 BC103508.1 
    BC104724.1 

    3 DOTS entries:

    DT.101977866  DT.86840964  DT.75114519 

    14 AceView cDNA sequences:

    BM676593 BM714205 NM_021628 AF182218 AJ269499 AW300461 AW003512 AW613990 
    AW593980 AK122822 BQ300190 CD693403 BG959287 BQ367813 

    GeneLoc Exon Structure

    2 Alternative Splicing Database (ASD) splice patterns (SP) for ALOXE3    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16
    SP1:                                                                                                            
    SP2:                                                                                                            


    ECgene alternative splicing isoforms for ALOXE3

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ALOXE3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TGGTCCCCTT

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)

    About this image
    See ALOXE3 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ALOXE3

    SOURCE GeneReport for Unigene cluster: Hs.232770

    UniProtKB/Swiss-Prot: LOXE3_HUMAN, Q9BYJ1
    Tissue specificity: Predominantly expressed in skin

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for ALOXE3 gene from 6/19 species (see all 19)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    chicken
    (Gallus gallus)
    Aves ALOXE31 arachidonate lipoxygenase 3 59.56(n)
    51.93(a)
      425997  XM_423676.3  XP_423676.3 
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    (see all 5)
    --
    54(a)
    52(a)
    (see all 5)
    many ↔ many
    many ↔ many
    (see all 5)
    GL343400.1(748887-766338)
    GL343400.1(642744-660332)
    African clawed frog
    (Xenopus laevis)
    Amphibia 480456692   -- 84.62(n)    48045669 
    zebrafish
    (Danio rerio)
    Actinopterygii LOC7941321 epidermis-type lipoxygenase 3-like 50.97(n)
    44.98(a)
      794132  XM_001333998.1  XP_001334034.1 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons LOX66
    LOX16
    (see all 6)
    lipoxygenase 1
    (see all 6)
    20(a)
    20(a)
    (see all 6)
    many ↔ many
    many ↔ many
    (see all 6)
    1(25319899-25324264)
    1(20525708-20530273)
    rice
    (Oryza sativa)
    Liliopsida --
    --
    (see all 13)
    lipozygenase protein, putative, expressed
    (see all 13)
    28(a)
    23(a)
    (see all 13)
    many ↔ many
    many ↔ many
    (see all 13)
    12(22901276-22903277)
    3(28084665-28087667)


    ENSEMBL Gene Tree for ALOXE3 (if available)
    TreeFam Gene Tree for ALOXE3 (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ALOXE3 gene
    ALOX12B2  ALOX52  ALOX15B2  ALOX122  ALOX152  
    6 SIMAP similar genes for ALOXE3 using alignment to 2 protein entries:     LOXE3_HUMAN (see all proteins):
    ALOX12B    arachidonate 12-lipoxygenase    ALOX15B    ALOX15    ALOX12    ALOX5

    ALOXE3 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for ALOXE3
    PGOHUM00000237219


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/526 NCBI SNPs in ALOXE3 are shown (see all 526    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1214342351,2
    C,F,pathogenic8015486(-) GGCTGT/ATGGAT 4 /M /L mis12Minor allele frequency- A:0.00NA EU 5873
    rs1214342331,2
    Cpathogenic8015495(-) AGCTTC/TGAGGG 4 R * stg11Minor allele frequency- T:0.00EU 1323
    rs10019581,2
    C,F,A,H,--7998809(-) CCACAC/TGGAGA 2 -- ds500113Minor allele frequency- T:0.44MN NS EA NA WA 912
    rs1468992331,2
    --7998878(+) GTACCC/GATCCA 2 -- ds50010--------
    rs10019571,2
    C,F,A,H,--7998904(-) GGAAGG/TCTCAG 2 -- ds50017Minor allele frequency- T:0.01MN NS EA CSA WA 715
    rs1479368861,2
    --7998917(+) GTGTCC/TAGGAG 2 -- ds50010--------
    rs752081111,2
    C,F,--7998936(+) GATTTC/TGGTGG 2 -- ds50011Minor allele frequency- T:0.03NA 120
    rs80795651,2
    C,F,H,--7999139(+) CACTGC/ATGCCC 2 -- ds50016Minor allele frequency- A:0.01NS EA CSA WA 540
    rs728455801,2
    C,F,--7999165(+) TGGCAC/ACCCCA 2 -- ds50011Minor allele frequency- A:0.03NA 120
    rs771499921,2
    --7999179(+) TCACCC/TACCCA 2 -- ds50013Minor allele frequency- T:0.08CSA WA NA 240

    HapMap Linkage Disequilibrium report for ALOXE3 (7999218 - 8022365 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 2 variations for ALOXE3
         1 CNV: 4988
         1 Indel: 72788
    Human Gene Mutation Database (HGMD): ALOXE3

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    ALOXE3 for disorders           About GeneDecksing

    OMIM gene information: 607206   
    OMIM disorders: 242100  
    UniProtKB/Swiss-Prot: LOXE3_HUMAN, Q9BYJ1
  • Defects in ALOXE3 are a cause of non-bullous congenital ichthyosiform erythroderma (NCIE) [MIM:242100]. NCIE
  • is a non-bullous ichthyosis, a skin disorder characterized by abnormal cornification of the epidermis. Most affected
    individuals are born with a tight, shiny, translucent covering called collodion membrane. The collodion membrane
    subsequently evolves into generalized scaling and intense redness of the skin. Clinical features are milder than in
    lamellar ichthyoses and demonstrate a greater variability in the intensity of erythema, size and type of scales. In
    contrast to lamellar ichthyoses, scales are usually white, fine and powdery, and palms and soles are severely
    affected. Patients suffer from palmoplantar keratoderma, often with painful fissures, digital contractures, and loss
    of pulp volume

    10 diseases for ALOXE3:    About MalaCards
    congenital ichthyosiform erythroderma    ichthyosis    autosomal recessive congenital ichthyosis    alcoholism
    anhidrosis    epithelial ovarian cancer    keratoderma    ovarian cancer
    meningioma    leukemia

    1 disease from the University of Copenhagen DISEASES database for ALOXE3:
    Congenital ichthyosiform erythroderma

    3 Novoseek disease relationships for ALOXE3 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    congenital ichthyosis 95.1 2 17608720 (1), 17139268 (1)
    ichthyosiform erythroderma congenital 91.7 7 11773004 (2), 15629692 (1), 16116617 (1)
    ichthyosis 89.3 4 15629692 (1), 19890349 (1), 17436029 (1), 18341575 (1)

    GeneTests: ALOXE3
    Autosomal Recessive Congenital Ichthyosis

    Human Genome Epidemiology (HuGE) Navigator: ALOXE3 (6 documents)

    Export disorders for ALOXE3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ALOXE3 gene, integrated from 9 sources (see all 33):
    (articles sorted by number of sources associating them with ALOXE3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Lipoxygenase-3 (ALOXE3) and 12(R)-lipoxygenase (ALOX12B) are mutated in non-bullous congenital ichthyosiform erythroderma (NCIE) linked to chromosome 17p13.1. (PubMed id 11773004)1, 2, 9 Jobard F.... Fischer J. (2002)
    2. A gene cluster encoding human epidermis-type lipoxygenases at chromosome 17p13.1: cloning, physical mapping, and expression. (PubMed id 11350124)1, 2, 9 Krieg P.... Fuerstenberger G. (2001)
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    5. Human and mouse eLOX3 have distinct substrate specificities: implications for their linkage with lipoxygenases in skin. (PubMed id 17045234)1, 9 Yu Z....Brash A.R. (2006)
    6. Mutations associated with a congenital form of ichthyosis (NCIE) inactivate the epidermal lipoxygenases 12R-LOX and eLOX3. (PubMed id 15629692)1, 9 Yu Z....Brash A.R. (2005)
    7. Epidermal lipoxygenase products of the hepoxilin pathway selectively activate the nuclear receptor PPARalpha. (PubMed id 17436029)1, 9 Yu Z....Brash A.R. (2007)
    8. Genotypic and clinical spectrum of self-improving col lodion ichthyosis: ALOX12B, ALOXE3, and TGM1 mutations in Scandinavian patients . (PubMed id 19890349)1, 9 Vahlquist A....Fischer J. (2010)
    9. Novel mutations in ALOX12B in patients with autosomal recessive congenital ichthyosis and evidence for genetic heterogeneity on chromosome 17p13. (PubMed id 17139268)1, 9 Lesueur F....Fischer J. (2007)
    10. Molecular analysis of 250 patients with autosomal recessive congenital ichthyosis: evidence for mutation hotspots in ALOXE3 and allelic heterogeneity in ALOX12B. (PubMed id 19131948)1, 9 Eckl K.M....Hennies H.C. (2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 59344 HGNC: 13743 AceView: ALOXE3 Ensembl:ENSG00000179148 euGenes: HUgn59344
    ECgene: ALOXE3 H-InvDB: ALOXE3

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ALOXE3 Pharmacogenomics, SNPs, Pathways
    GeneReviewshttp://www.ncbi.nlm.nih.gov/sites/GeneTests/lab/gene/ALOXE3

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for ALOXE3 gene:
    Search GeneIP for patents involving ALOXE3

    GeneCards and IP:
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