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ALOXE3 Gene

protein-coding GIFtS: 57

GC17M007939

arachidonate lipoxygenase 3
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
E-LOX ^¹, ²
EC 1.13.11.- ^³
MGC119694 ^²
MGC119695 ^²
MGC119696 ^²
e-LOX-3 ^³
eLOX3 ^¹, ²
lipoxygenase-3 ^²

Descriptions
arachidonate lipoxygenase 3 ^²
epidermal lipoxygenase ^²

External Ids
HGNC: 13743¹
Entrez Gene: 59344²
UniProtKB: Q9BYJ1³
Ensembl: ENSG00000179148⁷

Search outside databases for aliases for ALOXE3 gene

Previous GC identifers: GC17P008434 GC17M009087 GC17M007941 GC17M008199

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for ALOXE3:

The leukotrienes constitute a group of arachidonic acid-derived compounds with biologic activities

suggesting important roles in inflammation and immediate hypersensitivity. These compounds are

catabolized, in part, by lipoxygenases. Epidermis-type lipoxygenases, a distinct subclass within

the multigene family of mammalian lipoxygenases, are novel isoenzymes isolated from human and

mouse skin including human ALOX15B (MIM 603697), human and mouse ALOX12B (MIM 603741), mouse

8S-LOX, and mouse e-LOX-3.[supplied by OMIM]

UniProtKB/Swiss-Prot: LOXE3_HUMAN, Q9BYJ1

Function: Introduces molecular oxygen into polyunsaturated fatty acids. Exact substrate is not

known

Gene Wiki entry for ALOXE3

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the ALOXE3 gene

Entrez Gene cytogenetic band: 17p13.1 Ensembl cytogenetic band: 17p13.1 HGNC cytogenetic band: 17p13.1

ALOXE3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 17 GeneLoc Exon Structure

GeneLoc location for GC17M007939: (about GC identifiers)

Start:	7,939,943 bp from pter
End:	7,962,532 bp from pter
Size:	22,590 bases
Orientation:	minus strand

RefSeq DNA sequence:

NC_000017.9 NT_010718.15

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: LOXE3_HUMAN, Q9BYJ1 (See protein sequence)

Recommended Name: Epidermis-type lipoxygenase 3

Size: 711 amino acids; 80543 Da

Cofactor: Binds 1 iron ion per subunit (By similarity)

Secondary accessions: B2R981 Q3ZB74 Q9H4F2 Q9HC22

REFSEQ proteins: NP_067641.2

ENSEMBL proteins:

ENSP00000369494 ENSP00000314879

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (ALOXE3)
	Human Recombinant Proteins from Abnova (ALOXE3)

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

Antibodies for ALOXE3:

	Browse Antibodies Central at Invitrogen
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Browse Antibodies at Sigma-Aldrich
	Browse R&D Systems for Antibodies
	Antibodies from Abcam (ALOXE3), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (ALOXE3)
	Novus Biologicals Antibodies for ALOXE3

Assays for ALOXE3:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry Q9BYJ1

ProtoNet protein and cluster: Q9BYJ1

3 Blocks protein families:

IPB000907 Lipoxygenase

IPB001024 Lipoxygenase

IPB001885 Mammalian lipoxygenase signature

UniProtKB/Swiss-Prot: LOXE3_HUMAN, Q9BYJ1

Similarity: Belongs to the lipoxygenase family

Similarity: Contains 1 lipoxygenase domain

Similarity: Contains 1 PLAT domain

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (ALOXE3)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (ALOXE3)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_021628

Applied Biosystems Silencer® siRNAs for ALOXE3

Sigma-Aldrich siRNA and siRNA Panels for ALOXE3

Sigma-Aldrich shRNA for ALOXE3

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for ALOXE3
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_021628
Myc/DDK tagged cDNA clone in CMV expression vector: NM_021628
untagged cDNA clone in CMV expression vector: NM_021628

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_021628

UniProtKB/Swiss-Prot: LOXE3_HUMAN, Q9BYJ1

Function: Introduces molecular oxygen into polyunsaturated fatty acids. Exact substrate is not

known

Enzyme Number (IUBMB): EC 1.13.11.-

4 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005506	iron ion binding	IEA	--
GO:0016165	lipoxygenase activity	IEA	--
GO:0016491	oxidoreductase activity	IEA	--
GO:0046872	metal ion binding	IEA	--

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

2 Sigma-Aldrich "Your Favorite Gene" Pathways for ALOXE3 (Your Favorite Gene powered by Ingenuity)

Inositol Metabolism
Linoleic Acid Metabolism

GeneDecks ALOXE3 for the pathways selected above

About GeneDecksing

UniProtKB/Swiss-Prot: LOXE3_HUMAN, Q9BYJ1

Pathway: Lipid metabolism; leukotriene D4 biosynthesis

5 Interacting proteins for ALOXE3 (ENSP00000369494³) via UniProtKB, MINT, and/or STRING

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
LOX	ENSP00000231004³	STRING (score=.871)
HES7	ENSP00000314774³	STRING (score=.868)
TGM1	ENSP00000206765³	STRING (score=.795)
HES5	ENSP00000367714³	STRING (score=.746)
--	ENSP00000366793³	STRING (score=.865)

About this table

2 Gene Ontology (GO) biological process terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0019370	leukotriene biosynthetic process	IEA	--
GO:0055114	oxidation reduction	IEA	--

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Enzo Life Sciences drugs & compounds for ALOXE3

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for ALOXE3
3 Novoseek chemical compound relationships for ALOXE3 gene

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
12(r)-hpete	98.11	4	15629692 (1), 18086569 (1), 17045234 (1)
arachidonic acid	57.30	5	10569809 (1), 17608720 (1), 17436029 (1)
lipid	13.15	1	18341575 (1)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (ALOXE3)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (ALOXE3)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_021628

Sigma-Aldrich siRNA and siRNA Panels for ALOXE3

Sigma-Aldrich shRNA for ALOXE3

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_021628

REFSEQ mRNAs for ALOXE3 gene:

NM_021628.2

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_021628

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_021628
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_021628
                                 untagged cDNA clone in CMV expression vector: NM_021628

Additional cDNA sequence:

AF182218.1 AJ269499.1 AK292732.1 AK296416.1 AK299742.1 AK313677.1 BC101938.1 BC101939.1

BC103508.1 BC104724.1

2 DOTS entries:

DT.101977866 DT.86840964

14 AceView cDNA sequences:

BM714205 BM676593 AF182218 NM_021628 AJ269499 AW003512 AW613990 AW300461

AK122822 AW593980 CD693403 BG959287 BQ300190 BQ367813

highest scoring ESTs for ALOXE3:

AF182218 AJ269499 AK122822 AW300461 BG959287 BM676593 BM714205 BQ300190 BQ367813 CD693403

Unigene Cluster for ALOXE3:

Arachidonate lipoxygenase 3

Hs.694602 [show with all ESTs]

Unigene Representative Sequence: AJ269499

GeneLoc Exon Structure

2 Alternative Splicing Database (ASD) splice patterns (SP) for ALOXE3

ExUns:	1a	·	1b	^	2	^	3a	·	3b	^	4	^	5	^	6	^	7	^	8	^	9	^	10	^	11	^	12	^	13	^	14	^	15	^	16
SP1:
SP2:

About this scheme

ECgene alternative splicing isoforms for ALOXE3

2 Ensembl transcripts including schematic representations:

ENST00000380149 ENST00000318227

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

ALOXE3 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for ALOXE3

¹ / ² / ³

4 probe-sets matching ALOXE3 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
222383_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	AW003512	0.40	1.00	0.76	1
207708_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_021628	0.60	1.00	0.82	1
222383_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
207708_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

About this table

Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: --

SOURCE GeneReport for Unigene cluster: Hs.694602
UniProtKB/Swiss-Prot: LOXE3_HUMAN, Q9BYJ1
Tissue specificity: Predominantly expressed in skin

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for ALOXE3 gene from 5/7 species (see all 7 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	ALOXE3¹	--	arachidonate lipoxygenase 3	88.75(n) 88.61(a)	489487 XM_546605.2 XP_546605.2
cow (Bos taurus)	ALOXE3¹	--	arachidonate lipoxygenase 3	89.08(n) 89.31(a)	517001 XM_595164.3 XP_595164.3
rat (Rattus norvegicus)	Aloxe3¹	--	arachidonate lipoxygenase 3	85.79(n) 87.9(a)	287424 XM_213336.4 XP_213336.4
mouse (Mus musculus)	Aloxe3^{1, 5}	11 (37.00 cM)⁵	arachidonate lipoxygenase 3^{1, 5}	86.5(n)¹ 88.47(a)¹	23801¹ NM_011786.1¹ NP_035916.1¹ AK141003⁵ AL645527⁵ (see all 9)
chicken (Gallus gallus)	ALOXE3¹	--	arachidonate lipoxygenase 3	60.32(n) 52.38(a)	425997 XM_423676.2 XP_423676.2

About this table Species with no ortholog for ALOXE3

ENSEMBL Gene Tree for ALOXE3

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for ALOXE3 gene

ALOX5² ALOX12B²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/179 NCBI SNPs in ALOXE3 are shown (see all 179 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 112)

AB	SNP ID	Valid	Chr 17 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--				--
	rs3809882^1,2	A,C,F,H	7940314(-)	`TCCCCC/AATCCC`	1	--	ut3¹ ese³		5		EA EU WA	1904
	rs3027232^1,2	A,C,F,H	7962790(+)	`GCGCCG/AGCAAA`	1	--	ng3¹		10		EU EA WA	1016
	rs1001957^1,2	A,F,H	7939629(-)	`GGAAGG/TCTCAG`	1	--	ng5¹		5		MN EU EA WA	596
	rs1001958^1,2	A,F,H	7939534(-)	`CCACAC/TGGAGA`	1	--	ng5¹		5		MN EU EA WA	536
	rs1442847^1,2	A,C	7963890(+)	`ATCAGC/TATGTT`	1	--	ng3¹		0	--	--	--	--
--	rs9747063^1,2	A,C	7963784(+)	`AAGACA/CCCACG`	1	--	ng3¹		0	--	--	--	--
--	rs9748189^1,2	A,C	7963868(+)	`accttA/GaAGCT`	1	--	ng3¹		0	--	--	--	--
--	rs9747062^1,2	A,C	7963782(+)	`GAAAGA/CCACCA`	1	--	ng3¹		0	--	--	--	--
	rs3027229^1,2	C	7962333(+)	`ATCAGC/GAGCCT`	1	--	ut5¹ ese³		0	--	--	--	--
	rs8079565^1,2	H	7939864(+)	`CACTGC/ATGCCC`	1	--	ng5¹		4		EU EA WA	420

About this table

HapMap Linkage Disequilibrium images for ALOXE3 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 607206 disorders: 242100

UniProtKB/Swiss-Prot: LOXE3_HUMAN, Q9BYJ1

Defects in ALOXE3 are a cause of non-bullous congenital ichthyosiform erythroderma (NCIE)

[MIM:242100]. NCIE is a non-bullous ichthyosis, a skin disorder characterized by abnormal

cornification of the epidermis. Most affected individuals are born with a tight, shiny,

translucent covering called collodion membrane. The collodion membrane subsequently evolves into

generalized scaling and intense redness of the skin. Clinical features are milder than in lamellar

ichthyoses and demonstrate a greater variability in the intensity of erythema, size and type of

scales. In contrast to lamellar ichthyoses, scales are usually white, fine and powdery, and palms

and soles are severely affected. Patients suffer from palmoplantar keratoderma, often with painful

fissures, digital contractures, and loss of pulp volume

3 Novoseek disease relationships for ALOXE3 gene

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
congenital ichthyosis	93.36	2	17608720 (1), 17139268 (1)
ichthyosiform erythroderma congenital	92.15	7	11773004 (2), 15629692 (1), 16116617 (1)
ichthyosis	89.07	3	15629692 (1), 17436029 (1), 18341575 (1)

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GeneTests: ALOXE3

Autosomal Recessive Congenital Ichthyosis

Human Gene Mutation Database: ALOXE3
Human Genome Epidemiology Navigator: ALOXE3 (2 documents)

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/24 PubMed articles for ALOXE3 gene (see all 24 ):

Lipoxygenase-3 (ALOXE3) and 12(R)-lipoxygenase (ALOX12B) are mutated in non-bullous congenital ichthyosiform erythroderma (NCIE) linked to chromosome 17p13.1. (PubMed id 11773004)^{1, 3, 4} Jobard F.... Fischer J. (2002)
A gene cluster encoding human epidermis-type lipoxygenases at chromosome 17p13.1: cloning, physical mapping, and expression. (PubMed id 11350124)^{1, 3, 4} Krieg P.... Fuerstenberger G. (2001)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{3, 4} Ota T....Sugano S. (2004)
Human and mouse eLOX3 have distinct substrate specificities: implications for their linkage with lipoxygenases in skin. (PubMed id 17045234)^{1, 3} Yu Z....Brash A.R. (2006)
Mutations associated with a congenital form of ichthyosis (NCIE) inactivate the epidermal lipoxygenases 12R-LOX and eLOX3. (PubMed id 15629692)^{1, 3} Yu Z....Brash A.R. (2005)
Epidermal lipoxygenase products of the hepoxilin pathway selectively activate the nuclear receptor PPARalpha. (PubMed id 17436029)^{1, 3} Yu Z....Brash A.R. (2007)
Novel mutations in ALOX12B in patients with autosomal recessive congenital ichthyosis and evidence for genetic heterogeneity on chromosome 17p13. (PubMed id 17139268)^{1, 3} Lesueur F....Fischer J. (2007)
Molecular analysis of 250 patients with autosomal recessive congenital ichthyosis: evidence for mutation hotspots in ALOXE3 and allelic heterogeneity in ALOX12B. (PubMed id 19131948)^{1, 3} Eckl K.M....Hennies H.C. (2009)
Polymorphism in the IL18 gene and epithelial ovarian cancer in non-Hispanic white women. (PubMed id 19064572)³ Palmieri R.T.... . (2008)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 59344	HGNC: 13743	AceView: ALOXE3	Ensembl:ENSG00000179148	euGenes: HUgn59344
ECgene: ALOXE3	H-InvDB: ALOXE3

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
GeneReviews	http://www.genetests.org/query?gene=ALOXE3

Licensable Technologies for ALOXE3
(Available from WIS Yeda, Salk, Tufts)

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(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
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Products for ALOXE3:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for ALOXE3-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for ALOXE3		Browse antibodies at Sigma-Aldrich
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for ALOXE3		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

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	Drugs for ALOXE3
	Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Antibodies for ALOXE3

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ALOXE3 Gene

protein-coding GIFtS: 57

Aliases &
Descriptions
for ALOXE3

Summaries
for ALOXE3

Genomic Location
for ALOXE3

Proteins
for ALOXE3

Protein Domains/
Families
for ALOXE3

Gene Function
for ALOXE3

Pathways & Interactions
for ALOXE3

Drugs & Compounds
for ALOXE3

Transcripts
for ALOXE3

Expression
for ALOXE3

Orthologs
for ALOXE3

Paralogs
for ALOXE3

SNPs/Variants
for ALOXE3

Disorders & Mutations
for ALOXE3

Medical News
for ALOXE3

Publications
for ALOXE3

Search for ALOXE3

Genome Databases showing ALOXE3

Other Databases showing ALOXE3

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Licensable Technologies
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Services
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Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

ALOXE3 Gene

protein-coding GIFtS: 57

Aliases & Descriptionsfor ALOXE3

Summariesfor ALOXE3

Genomic Locationfor ALOXE3

Proteinsfor ALOXE3

Protein Domains/Familiesfor ALOXE3

Gene Functionfor ALOXE3

Pathways & Interactionsfor ALOXE3

Drugs & Compoundsfor ALOXE3

Transcriptsfor ALOXE3

Expression for ALOXE3

Orthologsfor ALOXE3

Paralogsfor ALOXE3

SNPs/Variantsfor ALOXE3

Disorders & Mutationsfor ALOXE3

Medical Newsfor ALOXE3

Publicationsfor ALOXE3

Search for ALOXE3

Genome Databases showing ALOXE3

Other Databases showing ALOXE3

Specialized Databases showing ALOXE3

Licensable Technologiesfor ALOXE3

Servicesfor ALOXE3

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for ALOXE3

Summaries
for ALOXE3

Genomic Location
for ALOXE3

Proteins
for ALOXE3

Protein Domains/
Families
for ALOXE3

Gene Function
for ALOXE3

Pathways & Interactions
for ALOXE3

Drugs & Compounds
for ALOXE3

Transcripts
for ALOXE3

Expression
for ALOXE3

Orthologs
for ALOXE3

Paralogs
for ALOXE3

SNPs/Variants
for ALOXE3

Disorders & Mutations
for ALOXE3

Medical News
for ALOXE3

Publications
for ALOXE3

Licensable Technologies
for ALOXE3

Services
for ALOXE3