Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ALOX5AP Gene

protein-coding   GIFtS: 67
GCID: GC13P031309

arachidonate 5-lipoxygenase-activating protein
 Explore 53 diseases affiliated with
ALOX5AP via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for ALOX5AP    

Aliases
for ALOX5AP gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Arachidonate 5-Lipoxygenase-Activating Protein1 2
FLAP1 2 3 5
MK-886-Binding Protein2 3

External Ids:    HGNC: 4361   Entrez Gene: 2412   Ensembl: ENSG000001329657   OMIM: 6037005   UniProtKB: P202923   

Export aliases for ALOX5AP gene to outside databases

Previous GC identifers: GC13P029289 GC13P025289 GC13P030239 GC13P029108 GC13P029109 GC13P030207 GC13P012127


Summaries
for ALOX5AP gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for ALOX5AP:
This gene encodes a protein which, with 5-lipoxygenase, is required for leukotriene synthesis. Leukotrienes are
arachidonic acid metabolites which have been implicated in various types of inflammatory responses, including asthma,
arthritis and psoriasis. This protein localizes to the plasma membrane. Inhibitors of its function impede
translocation of 5-lipoxygenase from the cytoplasm to the cell membrane and inhibit 5-lipoxygenase activation.
Alternatively spliced transcript variants encoding different isoforms have been identified for this gene. (provided by
RefSeq, Feb 2011)

UniProtKB/Swiss-Prot: AL5AP_HUMAN, P20292
Function: Required for leukotriene biosynthesis by ALOX5 (5-lipoxygenase). Anchors ALOX5 to the membrane. Binds
arachidonic acid, and could play an essential role in the transfer of arachidonic acid to ALOX5. Binds to MK-886, a
compound that blocks the biosynthesis of leukotrienes

summary for ALOX5AP:
Lipoxygenases (LOXs) are a family of non-heme iron dioxygenases that are involved in the production and
metabolism of fatty acid hydroperoxidases. There are six lipoxygenase isozymes; 5-LOX, 12R-LOX, 12S-LOX,
15-LOX-1 and 15-LOX-2, which catalyze the regio-selective addition of oxygen into arachidonic acid, and
epidermal LOX (E-LOX) which metabolizes 12R-hydroperoxyeicosatetraenoic acid (12R-HPETE) to a specific
epoxyalcohol compound. Different isozymes have different physiological roles; 5-, 12R-, 12S- and 15-LOX-1
have proliferative, antiapoptotic and angiogenic functions whilst 15-LOX-2 has roles in differentiation,
growth arrest and the induction of apoptosis. E-LOX, the most divergent member of this family, is involved
in terminal differentiation of keratinocytes and has a major role in skin barrier function. Perturbations in
lipoxygenase enzymes have been implicated in various human diseases including bronchial asthma,
atherosclerosis, osteoporosis and some cancers.

Gene Wiki entry for ALOX5AP (5-lipoxygenase-activating protein)


Genomic Views
for ALOX5AP gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000013.10  NC_018924.1  NT_024524.14  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ALOX5AP gene promoter:
         GR   STAT1   AML1a   AP-1   GATA-3   POU3F2 (N-Oct-5a)   POU3F2 (N-Oct-5b)   Nkx2-5   POU3F2   GR-alpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: ALOX5AP promoter sequence
   Search SABiosciences Chromatin IP Primers for ALOX5AP

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ALOX5AP


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 13q12   Ensembl cytogenetic band:  13q12.3   HGNC cytogenetic band: 13q12

ALOX5AP Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ALOX5AP gene location

GeneLoc information about chromosome 13         GeneLoc Exon Structure

GeneLoc location for GC13P031309:  view genomic region     (about GC identifiers)

Start:
 31,309,645 bp from pter      End:
 31,338,556 bp from pter
Size:
 28,912 bases      Orientation:
 plus strand

Proteins
for ALOX5AP gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: AL5AP_HUMAN, P20292 (See protein sequence)
Recommended Name: Arachidonate 5-lipoxygenase-activating protein  
Size: 161 amino acids; 18157 Da
Subunit: Homotrimer. Interacts with LTC4S and ALOX5
Subcellular location: Nucleus membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass
membrane protein
2 PDB 3D structures from and Proteopedia for ALOX5AP:
2Q7M (3D)        2Q7R (3D)    
Secondary accessions: Q5VV04

Explore the universe of human proteins at neXtProt for ALOX5AP: NX_P20292

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P20292

    • ALOX5AP Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (2 alternative transcripts): 
    NP_001191335.1  NP_001620.2  

    ENSEMBL proteins: 
     ENSP00000369858  
    Reactome Protein details: P20292
    Human Recombinant Protein Products: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein: ALOX5AP
    OriGene Protein Over-expression Lysate: ALOX5AP
    OriGene Custom Protein Services for ALOX5AP 
    GenScript Custom Purified and Recombinant Proteins Services for ALOX5AP
    Novus Biologicals ALOX5AP Protein
    Novus Biologicals ALOX5AP Lysate
    Sino Biological Recombinant Protein for ALOX5AP
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for ALOX5AP

    Gene Ontology (GO): 5/7 cellular component terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus ----
    GO:0005635nuclear envelope IDA19233132
    GO:0005783endoplasmic reticulum IDA19233132
    GO:0005789endoplasmic reticulum membrane IEA--
    GO:0005829cytosol IEA--


    ALOX5AP for ontologies           About GeneDecksing



    ALOX5AP Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    OriGene Antibodies (see all 3): ALOX5AP
    OriGene Custom Antibody Services for ALOX5AP 
    GenScript Custom Superior Antibodies Services for ALOX5AP
    Novus Biologicals ALOX5AP Antibodies
    Abcam antibodies for ALOX5AP 
    Uscn Antibodies for ALOX5AP
    ThermoFisher Antibodies for ALOX5AP

    Assay Products for ALOX5AP: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Immunoassay Development
    Browse OriGene Fluorogenic Cell Assay Kits
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for ALOX5AP
    Browse Enzo Life Sciences for kits & assays
    Uscn ELISAs and CLIAs for ALOX5AP

    Protein Domains /
    Families
    for ALOX5AP gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    ALOX5AP for domains           About GeneDecksing

    4 InterPro domains/families:
     IPR001446 5_LipOase_AP
     IPR018295 FLAP/GST2/LTC4S_CS
     IPR023352 MAPEG-like_dom
     IPR001129 Membr-assoc_MAPEG

    Graphical View of Domain Structure for InterPro Entry P20292

    ProtoNet protein and cluster: P20292

    2 Blocks protein families:
    IPB001129 Membrane-associated proteins in eicosanoid and glutathione metabolism (MAPEG)
    IPB001446 Five-lipoxygenase activating protein signature


    UniProtKB/Swiss-Prot: AL5AP_HUMAN, P20292
    Domain: The C-terminal part after residue 140 is mostly unstructured
    Similarity: Belongs to the MAPEG family


    Function
    for ALOX5AP gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: AL5AP_HUMAN, P20292
    Function: Required for leukotriene biosynthesis by ALOX5 (5-lipoxygenase). Anchors ALOX5 to the membrane. Binds
    arachidonic acid, and could play an essential role in the transfer of arachidonic acid to ALOX5. Binds to MK-886, a
    compound that blocks the biosynthesis of leukotrienes

         Genatlas biochemistry entry for ALOX5AP:
    arachidonate 5-lipoxygenase activating protein,expressed in cells of myeloid origin,localized in the nuclear
    envelop,involved in the biosynthesis of leukotrienes (role in inflammation),microsomal,GST superfamily

    miRNA
    Products:            		 OriGene 3'-UTR Clone: ALOX5AP
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ALOX5AP
    1 QIAGEN miScript miRNA Assays for microRNA that regulate ALOX5AP:
    hsa-miR-570
    SwitchGear 3'UTR luciferase reporter plasmid: ALOX5AP 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ALOX5AP (see all 7)
    OriGene shRNA RFP: ALOX5AP
    OriGene siRNA: ALOX5AP
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ALOX5AP

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for ALOX5AP

    Clone
    Products:             		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ALOX5AP (see all 3)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ALOX5AP
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector (see all 2): ALOX5AP (NM_001629)
    Sino Biological Human cDNA Clone for ALOX5AP
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ALOX5AP
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ALOX5AP 

    Cell Line
    Products:             		GenScript Custom overexpressing Cell Line Services for ALOX5AP
    Search LifeMap BioReagents cell lines for ALOX5AP

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ALOX5AP

    Gene Ontology (GO): 5/11 molecular function terms (GO ID links to tree view) (see all 11):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004051arachidonate 5-lipoxygenase activity IBA--
    GO:0004364glutathione transferase activity IBA--
    GO:0004464NOT leukotriene-C4 synthase activity IBA--
    GO:0004602glutathione peroxidase activity IBA--
    GO:0005515protein binding IPI19233132


    ALOX5AP for ontologies           About GeneDecksing


    1 GenomeRNAi human phenotype for ALOX5AP:
     Synthetic lethal with c-Myc af 

    Animal Models:
         Mouse knock-outs for ALOX5AP: Alox5aptm1Jdm Alox5aptm1Bhk
         3 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Alox5ap):
     homeostasis/metabolism  immune system  skeleton 

    ALOX5AP for phenotypes           About GeneDecksing


    Pathways & Interactions
    for ALOX5AP gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/6 super-pathways (see all 6) About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Metabolism
    		Metabolism1.00
    		Metabolism of lipids and lipoproteins0.34
    2Arachidonic acid metabolism
    		Arachidonic acid metabolism1.00
    		Eicosanoid Synthesis0.31
    3Synthesis of 15-eicosatetraenoic acid derivatives
    		Synthesis of 5-eicosatetraenoic acids0.33
    		Synthesis of Lipoxins (LX)0.00
    4leukotriene biosynthesis
    		Synthesis of Leukotrienes (LT) and Eoxins (EX)0.47
    		Leukotriene modifiers pathway, Pharmacodynamics0.33
    5Selenium Pathway
    		Selenium Pathway1.00

    Pathway sources
    See GeneCards unified pathways
    Show all pathways


    3 BioSystems Pathways for ALOX5AP 
        Eicosanoid Synthesis
    Selenium Pathway
    IL-5 Signaling Pathway

    5/6        Reactome Pathways for ALOX5AP (see all 6)
        Synthesis of Lipoxins (LX)
    Metabolism
    Synthesis of Leukotrienes (LT) and Eoxins (EX)
    Arachidonic acid metabolism
    Synthesis of 5-eicosatetraenoic acids

    1 PharmGKB Pathway for ALOX5AP
        Leukotriene modifiers pathway, Pharmacodynamics


    ALOX5AP for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for ALOX5AP

    STRING Interaction Network Preview (showing 5 interactants - click image to see 6)

    5/6 Interacting proteins for ALOX5AP (P202923 ENSP000003698584) via UniProtKB, MINT, STRING, and/or I2D (see all 6)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ALOX5P099173, ENSP000003635124I2D: score=3 STRING: ENSP00000363512
    LTC4SQ168733, ENSP000002925964I2D: score=1 STRING: ENSP00000292596
    LTA4HENSP000002287404STRING: ENSP00000228740
    ABCC1ENSP000003823424STRING: ENSP00000382342
    MAPKAPK2ENSP000003560704STRING: ENSP00000356070
    About this table

    Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0002540leukotriene production involved in inflammatory response IEA--
    GO:0002675positive regulation of acute inflammatory response IEA--
    GO:0006750glutathione biosynthetic process IBA--
    GO:0019370leukotriene biosynthetic process IDA2300173
    GO:0070207protein homotrimerization IPI17600184


    ALOX5AP for ontologies           About GeneDecksing



    Drugs & Compounds
    for ALOX5AP gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    ALOX5AP for compounds           About GeneDecksing

    EMD Millipore small molecules for ALOX5AP:
    Small Molecule - inhibitor
    Enzo Life Sciences drugs & compounds for ALOX5AP

    Compounds for ALOX5AP available from Tocris Bioscience    About this table
    CompoundAction CAS #
    BAY-X 1005Orally active 5-lipoxygenase activating protein (FLAP) inhibitor[128253-31-6]
    10/31 Novoseek chemical compound relationships for ALOX5AP gene (see all 31)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    5-hpete 87.7 5 8344271 (2), 9630716 (1), 7473582 (1)
    mk 886 86.6 17 10333477 (4), 11389700 (2), 16817014 (1), 19346216 (1) (see all 10)
    ltc4 86.1 63 8703034 (5), 9278457 (4), 9431445 (3), 8052639 (3) (see all 17)
    arachidonic acid 82.5 108 8049076 (4), 8440384 (3), 8344271 (3), 10036194 (2) (see all 47)
    leukotriene b4 80.9 28 15593193 (3), 9150468 (2), 9609743 (2), 17156456 (2) (see all 19)
    zileuton 78.5 5 9609743 (2), 12649539 (1), 18037915 (1), 9113110 (1)
    5-hydroxyeicosatetraenoic acid 78.3 6 8358023 (3), 16185917 (1), 11090070 (1)
    montelukast 60.8 4 18591367 (1), 19058495 (1), 18037915 (1), 17460547 (1)
    pranlukast 58.7 1 19058495 (1)
    zafirlukast 55.3 1 19058495 (1)

    Search CenterWatch for drugs/clinical trials and news about ALOX5AP / AL5AP 

    Transcripts
    for ALOX5AP gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for ALOX5AP gene (2 alternative transcripts): 
    NM_001204406.1  NM_001629.3  

    Unigene Cluster for ALOX5AP:

    Arachidonate 5-lipoxygenase-activating protein
    Hs.507658  [show with all ESTs]
    Unigene Representative Sequence: BU198818
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000380490(uc010tdr.2 uc001utf.2) ENST00000479597

    miRNA
    Products:             		 OriGene 3'-UTR Clone: ALOX5AP
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ALOX5AP
    1 QIAGEN miScript miRNA Assays for microRNA that regulate ALOX5AP:
    hsa-miR-570
    SwitchGear 3'UTR luciferase reporter plasmid: ALOX5AP 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ALOX5AP (see all 7)
    OriGene shRNA RFP: ALOX5AP
    OriGene siRNA: ALOX5AP
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ALOX5AP
    Clone
    Products:             		 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ALOX5AP (see all 3)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ALOX5AP
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector (see all 2): ALOX5AP (NM_001629)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ALOX5AP
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ALOX5AP 
    Primer
    Products:            		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ALOX5AP
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat ALOX5AP
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ALOX5AP
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ALOX5AP

    Additional cDNA sequence: 

    AK314143.1 BC018538.1 

    13 DOTS entries:

    DT.455424  DT.92432935  DT.120780307  DT.92432937  DT.100036052  DT.92045150  DT.95234653  DT.95339664 
    DT.100036055  DT.100036056  DT.100036057  DT.100705468  DT.95271540 

    24/167 AceView cDNA sequences (see all 167):

    BQ184220 BQ187112 CD369702 CK299583 BM773521 BF974456 BQ003388 H02419 
    BM992846 BM823620 AA353170 NM_001629 CA307605 CA306377 AV716674 AV716937 
    CA310357 BQ016999 BQ029402 CD370101 BX350312 BX366320 BU199063 BM725948 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for ALOX5AP    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5 ^ 6a · 6b
    SP1:              -     -           -                           
    SP2:                                -                           
    SP3:              -     -           -     -     -               
    SP4:                    -                                       


    ECgene alternative splicing isoforms for ALOX5AP

    Expression
    for ALOX5AP gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ALOX5AP expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TTTTAAGCTG

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    ALOX5AP expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    1 LifeMap In Vivo Development Anatomical Compartment/Cell 
    Tissue Anatomical Compartment CellCategory (developmental path)
    LiverLiver LobuleLiver
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization
    Stem Cell Differentiation: 6 LifeMap Cells 
    NameCategory
    PureStem™ progenitor E68 (Embryonic Progenitor Cell)
    PureStem™ mesenchymal Progenitor SK11 (Embryonic Progenitor Cell)Adipose, Bone, Cartilage
    PureStem™ progenitor EN13 (Embryonic Progenitor Cell)
    PureStem™ progenitor EN2 (Embryonic Progenitor Cell)
    PureStem™ progenitor EN27 (Embryonic Progenitor Cell)
    PureStem™ progenitor SK17 (Embryonic Progenitor Cell)

    See ALOX5AP Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ALOX5AP

    SOURCE GeneReport for Unigene cluster: Hs.507658
        SABiosciences Custom PCR Arrays for ALOX5AP
    Primer
    Products:    		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ALOX5AP
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat ALOX5AP
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ALOX5AP
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ALOX5AP
    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ALOX5AP

    Orthologs
    for ALOX5AP gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of chordates.

    Orthologs for ALOX5AP gene from 4/13 species (see all 13)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves ALOX5AP1 arachidonate 5-lipoxygenase-activating protein 76.19(n)
    82.61(a)    		   770904  XM_001233118.2  XP_001233119.1 
    lizard
    (Anolis carolinensis)    		 Reptilia ALOX5AP6
    		 --
    		 73(a)
    		 1 ↔ 1
    		 3(184491481-184504606)
    tropical clawed frog
    (Xenopus tropicalis)    		 Amphibia Str.118192 Transcribed sequence with moderate similarity to protein more 73.55(n)    CF343935.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii wufj65d022 wufj65d02 73.41(n)   337376  BC053181.1 


    ENSEMBL Gene Tree for ALOX5AP (if available)
    TreeFam Gene Tree for ALOX5AP (if available) 

    Paralogs
    for ALOX5AP gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ALOX5AP gene
    LTC4S2  MGST22  
    2 SIMAP similar genes for ALOX5AP using alignment to 1 protein entry:     AL5AP_HUMAN:
    LTC4S    MGST2

    ALOX5AP for paralogs           About GeneDecksing



    Genomic Variants
    for ALOX5AP gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1162 NCBI SNPs in ALOX5AP are shown (see all 1162)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 13 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs619473721,2
    		C,--12103598(+) GAGCAG/ACCTCA 1 -- us2k13Minor allele frequency- A:0.06NA WA 240
    rs1166084191,2
    		C,F,--12103621(+) TTCCAT/GTTTGG 1 -- us2k11Minor allele frequency- G:0.03WA 118
    rs773836721,2
    		C,--12103810(+) GAAATC/ATGGAA 1 -- us2k11Minor allele frequency- A:0.50NA 2
    rs789919051,2
    		C,F,--12105106(+) CTGGCG/ATGCAT 1 -- us2k11Minor allele frequency- A:0.11WA 118
    rs594240951,2
    		C,F,--12105739(+) TTTGCC/ACCCTC 1 -- ut511Minor allele frequency- A:0.19WA 118
    rs95088251,2
    		C,--12105814(+) AACTCT/CGTAGA 1 -- ut513Minor allele frequency- C:0.05NA WA 122
    rs93150351,2
    		C,--12106003(+) GTGCGC/TGCACA 1 -- int12Minor allele frequency- T:0.25NA 4
    rs595344271,2
    		C,F,--12106059(+) CTGGGC/TCCAGG 1 -- int11Minor allele frequency- T:0.19WA 118
    rs95088261,2
    		C,--12106091(+) GAACCG/AAGGCT 1 -- int13Minor allele frequency- A:0.05NA WA 122
    rs754374391,2
    		F,--12106213(+) TCAGAC/TTCCTA 1 -- int11Minor allele frequency- T:0.03WA 118

    HapMap Linkage Disequilibrium report for ALOX5AP (31309645 - 31338556 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for ALOX5AP: --
    Human Gene Mutation Database (HGMD): ALOX5AP

    Locus Specific Mutation Databases (LSDB): ALOX5AP

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ALOX5AP
    DNA2.0 Custom Variant and Variant Library Synthesis for ALOX5AP

    Disorders / Diseases
    for ALOX5AP gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    ALOX5AP for disorders           About GeneDecksing

    OMIM gene information: 603700   
    OMIM disorders: 601367  
    UniProtKB/Swiss-Prot: AL5AP_HUMAN, P20292
  • Genetic variations in ALOX5AP may be a cause of susceptibility to ischemic stroke (ISCHSTR) [MIM:601367]; also
    • known as cerebrovascular accident or cerebral infarction. A stroke is an acute neurologic event leading to death of
    neural tissue of the brain and resulting in loss of motor, sensory and/or cognitive function. Ischemic strokes,
    resulting from vascular occlusion, is considered to be a highly complex disease consisting of a group of heterogeneous
    disorders with multiple genetic and environmental risk factors
  • Note=Genetic variations in ALOX5AP may be associated with susceptibility to myocardial infarction. Involvement
    • in myocardial infarction is however unclear: according to some authors (PubMed:14770184), a 4-SNP haplotype in ALOX5AP
    confers risk of myocardial infarction, while according to other (PubMed:17304054) ALOX5AP is not implicated in this
    condition

    20/53 diseases for ALOX5AP (see all 53):    About MalaCards
    bronchial asthma    asthma    psoriasis    osteoporosis
    atherosclerosis    arthritis    type 2 diabetes mellitus    cerebrovascular accident
    myocardial infarction    mantle cell lymphoma    acquired immunodeficiency syndrome    primary pulmonary hypertension
    allergic rhinitis    coronary heart disease    diabetes mellitus    pulmonary hypertension
    familial hypercholesterolemia    sickle cell disease    rheumatoid arthritis    cerebral palsy

    1 disease from the University of Copenhagen DISEASES database for ALOX5AP:
    Cerebrovascular accident

    10/23 Novoseek disease relationships for ALOX5AP gene (see all 23)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    thrombotic stroke 62.7 1 16939001 (1)
    asthma 57.7 41 20067482 (6), 15784112 (5), 18547289 (4), 12911785 (4) (see all 14)
    stroke 37.8 59 19126581 (4), 15731479 (4), 15640973 (3), 16939001 (3) (see all 20)
    myocardial infarction 37.1 33 14770184 (3), 16778124 (3), 16282974 (2), 17176247 (2) (see all 14)
    inflammation 37 8 19239910 (2), 16261187 (1), 19759251 (1), 18775537 (1) (see all 7)
    cardiovascular diseases 31.5 6 15640973 (2), 16261187 (1), 19239910 (1), 16778124 (1)
    atherosclerosis 27.6 5 20376802 (2), 18258817 (1), 15581413 (1), 16278051 (1)
    asthma allergic 27.6 1 8994519 (1)
    coronary artery disease 16.7 6 19596330 (3), 17505527 (2), 15861005 (1), 18318662 (1)
    nephropathy iga 10.1 1 8468935 (1)

    Genetic Association Database (GAD): ALOX5AP
    Human Genome Epidemiology (HuGE) Navigator: ALOX5AP (69 documents)

    Export disorders for ALOX5AP gene to outside databases

    Publications
    for ALOX5AP gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ALOX5AP gene, integrated from 9 sources (see all 254):
    (articles sorted by number of sources associating them with ALOX5AP)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Gene characterization and promoter analysis of the human 5- lipoxygenase-activating protein (FLAP). (PubMed id 1673682)1, 2, 3, 9 Kennedy B.P.... Dixon R.A.F. (1991)
    2. The gene encoding 5-lipoxygenase activating protein confers risk of myocardial infarction and stroke. (PubMed id 14770184)1, 2, 4, 9 Helgadottir A.... Stefansson K. (2004)
    3. Polymorphisms in the 5-lipoxygenase activating protein (ALOX5AP) gene are not associated with asthma in an Australian population. (PubMed id 15784112)1, 4, 9 Kedda M.A....Thompson P.J. (2005)
    4. 5-lipoxygenase and 5-lipoxygenase-activating protein are localized in the nuclear envelope of activated human leukocytes. (PubMed id 8245774)1, 2, 9 Woods J.W....Singer I.I. (1993)
    5. Cytogenetic and radiation hybrid mapping of human ara chidonate 5-lipoxygenase-activating protein (ALOX5AP) to chromosome 13q12. (PubMed id 10036194)1, 3, 9 Yandava C.N....Drazen J.M. (1999)
    6. Effects of a 5-lipoxygenase-activating protein inhibitor on biomarkers associated with risk of myocardial infarction: a randomized trial. (PubMed id 15886380)1, 4, 9 Hakonarson H....Stefansson K. (2005)
    7. ALOX5AP gene and the PDE4D gene in a central European population of stroke patients. (PubMed id 15731479)1, 4, 9 Lohmussaar E....Dichgans M. (2005)
    8. Polymorphism of tandem repeat in promoter of 5-lipoxygenase in ASA-intolerant asthma: a positive association with airway hyperresponsiveness. (PubMed id 15876305)1, 4, 9 Kim S.H....Park H.S. (2005)
    9. Promoter polymorphism in the 5-lipoxygenase (ALOX5) and 5-lipoxygenase-activating protein (ALOX5AP) genes and asthma susceptibility in a Caucasian population. (PubMed id 12911785)1, 4, 9 Sayers I....Holgate S.T. (2003)
    10. 5-lipoxygenase-activating protein is an arachidonate binding protein. (PubMed id 8440384)1, 2, 9 Mancini J.A.... Vickers P.J. (1993)

    External Searches for ALOX5AP gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing ALOX5AP gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 241 HGNC: 436 AceView: ALOX5AP Ensembl:ENSG00000132965 euGenes: HUgn241
    ECgene: ALOX5AP H-InvDB: ALOX5AP

    Other Databases showing ALOX5AP gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing ALOX5AP gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ALOX5AP Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for ALOX5AP Genetics and Cytogenetics in Oncology and Haematology
    SeattleSNPshttp://pga.gs.washington.edu/data/alox5ap/

    Intellectual Property
    for ALOX5AP gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for ALOX5AP gene:
    Search GeneIP for patents involving ALOX5AP

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    Products
    for ALOX5AP gene

    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
    In Situ Hybridization Assays from
    Advanced Cell Diagnostics
    About This Section

     Browse Kits and Assays available from EMD Millipore
     Browse Purified and Recombinant Proteins at EMD Millipore
     Browse for Gene Knock-down Tools from EMD Millipore
     Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
     EMD Millipore small molecules (inhibitor) for ALOX5AP
     Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Phosphatase Activity Assays/Reagents   Browse Recombinant/Natural Proteins  
     OriGene Antibodies for ALOX5AP   OriGene shRNA RFP for ALOX5AP  
     OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ALOX5AP   OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ALOX5AP  
     OriGene Protein Over-expression Lysate for ALOX5AP   Browse OriGene Fluorogenic Cell Assay Kits  
     OriGene siRNA for ALOX5AP   OriGene 3'-UTR Clone for ALOX5AP  
     OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ALOX5AP   OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ALOX5AP  
     Browse OriGene GFP tagged cDNA clones in CMV expression vector   Browse OriGene MicroRNA Expression Plasmids  
     Browse OriGene basic RS shRNAs   Browse OriGene validated miRNA SYBR primer pairs  
     OriGene Purified Protein for ALOX5AP   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for ALOX5AP   OriGene Custom Protein Services for ALOX5AP  
     OriGene Custom Immunoassay Development  

         		 
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat ALOX5AP
     QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ALOX5AP
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ALOX5AP
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ALOX5AP
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ALOX5AP
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ALOX5AP
     GenScript Custom Purified and Recombinant Proteins Services for ALOX5AP GenScript cDNA clones with any tag delivered in your preferred vector for ALOX5AP
     GenScript Custom Assay Services for ALOX5AP GenScript Custom Superior Antibodies Services for ALOX5AP
     GenScript Custom overexpressing Cell Line Services for ALOX5AP CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in ALOX5AP promoter
     Search Chromatin IP Primers for ALOX5AP
     RT2 qPCR Primer Assay in human, mouse, rat ALOX5AP
     GNC Network for ALOX5AP
     SABiosciences Custom PCR Arrays for ALOX5AP
     Tocris compounds for ALOX5AP
     Proteins and Antibodies for ALOX5AP
     cDNA Clones for ALOX5AP
     Antibodies/Proteins Production Services
     Rabbit Monoclonal Antibody Platform
     Bulk Purchasing
     Drugs for ALOX5AP
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     ALOX5AP antibodies
     ALOX5AP proteins
     ALOX5AP lysates
     Antibodies for ALOX5AP
     See all of Abcam's Antibodies, Kits and Proteins for ALOX5AP
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     ALOX5AP Proteins, Antibodies, CLIAs, and ELISAs
     Search LifeMap BioReagents cell lines for ALOX5AP
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ALOX5AP
     SwitchGear 3'UTR luciferase reporter plasmids for ALOX5AP
     SwitchGear Promoter luciferase reporter plasmids for ALOX5AP
     ThermoFisher Antibodies for ALOX5AP
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ALOX5AP
           
    GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

    View Random Gene

    Category
    VWF
    (GIFTS: 73)
    von Willebrand factor
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 

    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Copyright © 1996-2013 , Weizmann Institute of Science. All Rights Reserved.
    Hot genes      Disease genes      ALOX5AP gene at Home site.
    hostname: 356980-web2.xennexinc.com index build: 100 solr: 1.4