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ALOX5AP Gene

protein-coding GIFtS: 65
GCID: GC13P031309

Arachidonate 5-Lipoxygenase-Activating Protein

See ALOX5AP-related diseases
at

MalaCards

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, ¹⁰fRNAdb, ¹²H-InvDB, ¹³NCBI, ¹⁴NONCODE, and/or ¹⁵RNAdb)
About This Section

Aliases
Arachidonate 5-Lipoxygenase-Activating Protein¹ ²
MK-886-Binding Protein¹ ² ³
FLAP² ³ ⁵
Five-Lipoxygenase Activating Protein¹

External Ids:	HGNC: 436¹	Entrez Gene: 241²	Ensembl: ENSG00000132965⁷	OMIM: 603700⁵	UniProtKB: P20292³

Export aliases for ALOX5AP gene to outside databases

Previous GC identifers: GC13P029289 GC13P025289 GC13P030239 GC13P029108 GC13P029109 GC13P030207 GC13P012127

(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for ALOX5AP Gene:

This gene encodes a protein which, with 5-lipoxygenase, is required for leukotriene synthesis. Leukotrienes are

arachidonic acid metabolites which have been implicated in various types of inflammatory responses, including

asthma, arthritis and psoriasis. This protein localizes to the plasma membrane. Inhibitors of its function impede

translocation of 5-lipoxygenase from the cytoplasm to the cell membrane and inhibit 5-lipoxygenase activation.

Alternatively spliced transcript variants encoding different isoforms have been identified for this gene.

(provided by RefSeq, Feb 2011)

GeneCards Summary for ALOX5AP Gene:

ALOX5AP (arachidonate 5-lipoxygenase-activating protein) is a protein-coding gene. Diseases associated with ALOX5AP include cerebrovascular disease, and asthma. GO annotations related to this gene include enzyme binding and protein homodimerization activity. An important paralog of this gene is LTC4S.

UniProtKB/Swiss-Prot: AL5AP_HUMAN, P20292

Function: Required for leukotriene biosynthesis by ALOX5 (5-lipoxygenase). Anchors ALOX5 to the membrane. Binds

arachidonic acid, and could play an essential role in the transfer of arachidonic acid to ALOX5. Binds to MK-886,

a compound that blocks the biosynthesis of leukotrienes

summary for ALOX5AP Gene:

Lipoxygenases (LOXs) are a family of non-heme iron dioxygenases that are involved in the production and

metabolism of fatty acid hydroperoxidases. There are six lipoxygenase isozymes; 5-LOX, 12R-LOX, 12S-LOX,

15-LOX-1 and 15-LOX-2, which catalyze the regio-selective addition of oxygen into arachidonic acid, and

epidermal LOX (E-LOX) which metabolizes 12R-hydroperoxyeicosatetraenoic acid (12R-HPETE) to a specific

epoxyalcohol compound. Different isozymes have different physiological roles; 5-, 12R-, 12S- and 15-LOX-1

have proliferative, antiapoptotic and angiogenic functions whilst 15-LOX-2 has roles in differentiation,

growth arrest and the induction of apoptosis. E-LOX, the most divergent member of this family, is involved

in terminal differentiation of keratinocytes and has a major role in skin barrier function. Perturbations in

lipoxygenase enzymes have been implicated in various human diseases including bronchial asthma,

atherosclerosis, osteoporosis and some cancers.

Gene Wiki entry for ALOX5AP (5-lipoxygenase-activating protein) Gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence at NCBI GenBank:

NC_000013.10 NC_018924.2 NT_024524.15

Regulatory elements:

Regulatory transcription factor binding sites in the ALOX5AP gene promoter:
GR STAT1 AML1a AP-1 GATA-3 POU3F2 (N-Oct-5a) POU3F2 (N-Oct-5b) Nkx2-5 POU3F2 GR-alpha
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: ALOX5AP promoter sequence

Search Chromatin IP Primers for ALOX5AP

Epigenetics:

DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ALOX5AP

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 13q12 Ensembl cytogenetic band: 13q12.3 HGNC cytogenetic band: 13q12

ALOX5AP Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ALOX5AP gene location

GeneLoc information about chromosome 13 GeneLoc Exon Structure

GeneLoc location for GC13P031309: view genomic region (about GC identifiers)

Start:	31,287,615 bp from pter	End:	31,338,565 bp from pter
Size:	50,951 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, ²neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, antibodies-online, and/or GeneTex,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
About This Section

UniProtKB/Swiss-Prot: AL5AP_HUMAN, P20292 (See protein sequence)

Recommended Name: Arachidonate 5-lipoxygenase-activating protein

Size: 161 amino acids; 18157 Da

Subunit: Homotrimer. Interacts with LTC4S and ALOX5

2 PDB 3D structures from and Proteopedia for ALOX5AP:

2Q7M (3D)

2Q7R (3D)

Secondary accessions: Q5VV04

Explore the universe of human proteins at neXtProt for ALOX5AP: NX_P20292

Explore proteomics data for ALOX5AP at MOPED

See ALOX5AP Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins (2 alternative transcripts):

NP_001191335.1 NP_001620.2

ENSEMBL proteins:

ENSP00000369858

Reactome Protein details: P20292

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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GenesLikeMe)
About This Section

4 InterPro protein domains:

IPR001446 5_LipOase_AP

IPR018295 FLAP/GST2/LTC4S_CS

IPR023352 MAPEG-like_dom

IPR001129 Membr-assoc_MAPEG

Graphical View of Domain Structure for InterPro Entry P20292

ProtoNet protein and cluster: P20292

2 Blocks protein domains:

IPB001129 Membrane-associated proteins in eicosanoid and glutathione metabolism (MAPEG)

IPB001446 Five-lipoxygenase activating protein signature

UniProtKB/Swiss-Prot: AL5AP_HUMAN, P20292

Domain: The C-terminal part after residue 140 is mostly unstructured

Similarity: Belongs to the MAPEG family

Find genes that share domains with ALOX5AP About GenesLikeMe

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: AL5AP_HUMAN, P20292

Function: Required for leukotriene biosynthesis by ALOX5 (5-lipoxygenase). Anchors ALOX5 to the membrane. Binds

arachidonic acid, and could play an essential role in the transfer of arachidonic acid to ALOX5. Binds to MK-886,

a compound that blocks the biosynthesis of leukotrienes

Genatlas biochemistry entry for ALOX5AP:

arachidonate 5-lipoxygenase activating protein,expressed in cells of myeloid origin,localized in the nuclear

envelop,involved in the biosynthesis of leukotrienes (role in inflammation),microsomal,GST superfamily

Gene Ontology (GO): Selected molecular function terms (see all 10): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004364	NOT glutathione transferase activity	IBA	--
GO:0004464	NOT leukotriene-C4 synthase activity	IBA	--
GO:0004602	NOT glutathione peroxidase activity	IBA	--
GO:0005515	protein binding	IPI	19233132
GO:0008047	enzyme activator activity	IEA	--

Find genes that share ontologies with ALOX5AP About GenesLikeMe

Phenotypes:
1 GenomeRNAi human phenotype for ALOX5AP:

Synthetic lethal with c-Myc af

4 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Alox5ap):

hematopoietic system

homeostasis/metabolism

immune system

skeleton

Find genes that share phenotypes with ALOX5AP About GenesLikeMe

Animal Models:
MGI mouse knock-outs for ALOX5AP: Alox5ap^tm1Jdm Alox5ap^tm1Bhk

genOway: Develop your customized and physiologically relevant rodent model for ALOX5AP

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		hsa-miR-570
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Gene Editing
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In Situ Assay
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Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ALOX5AP

(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
About This Section

Subcellular locations from UniProtKB/Swiss-Prot

AL5AP_HUMAN, P20292: Nucleus membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass

membrane protein

Subcellular locations from COMPARTMENTS:

Compartment	Confidence
endoplasmic reticulum	5
nucleus	5
cytosol	2
lysosome	2
plasma membrane	2

About this image

Gene Ontology (GO): Selected cellular component terms (see all 7): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	--	--
GO:0005635	nuclear envelope	TAS	--
GO:0005783	endoplasmic reticulum	IDA	19233132
GO:0005789	endoplasmic reticulum membrane	IEA	--
GO:0005829	cytosol	IEA	--

Find genes that share ontologies with ALOX5AP About GenesLikeMe

(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GenesLikeMe, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
About This Section

SuperPaths for ALOX5AP About (see all 6)

See pathways by source

Powered
by

SuperPath

Contained pathways About

Arachidonic acid metabolism

	Arachidonic acid metabolism	0.40			Synthesis of 5-eicosatetraenoic acids	0.00
	Synthesis of Leukotrienes (LT) and Eoxins (EX)	0.00			Synthesis of Lipoxins (LX)	0.00

Metabolism

Metabolism

0.38

Metabolism of lipids and lipoproteins

0.37

Selenium Pathway

Selenium Pathway

Leukotriene modifiers pathway, Pharmacodynamics

Leukotriene modifiers pathway, Pharmacodynamics

IL-5 Signaling Pathway

IL-5 Signaling Pathway

Find genes that share SuperPaths with ALOX5AP About GenesLikeMe

Pathways by source See SuperPaths
Show all pathways

3 BioSystems Pathways for ALOX5AP

	Eicosanoid Synthesis
	IL-5 Signaling Pathway
	Selenium Pathway

3 Reactome Pathways for ALOX5AP

	Synthesis of Lipoxins (LX)
	Synthesis of Leukotrienes (LT) and Eoxins (EX)
	Synthesis of 5-eicosatetraenoic acids

1 PharmGKB Pathway for ALOX5AP

Leukotriene modifiers pathway, Pharmacodynamics

Custom Pathway & Disease-focused RT² Profiler PCR Arrays for ALOX5AP
Interactions:

GeneGlobe Interaction Network for ALOX5AP

STRING Interaction Network Preview (showing 5 interactants - click image to see 9)

Selected Interacting proteins for ALOX5AP (P20292³ ENSP00000369858⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 9)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
ALOX5	P09917³, ENSP00000363512⁴	I2D: score=3 STRING: ENSP00000363512
LTC4S	Q16873³, ENSP00000292596⁴	I2D: score=1 STRING: ENSP00000292596
LTA4H	ENSP00000228740⁴	STRING: ENSP00000228740
ABCC1	ENSP00000382342⁴	STRING: ENSP00000382342
MAPKAPK2	ENSP00000356070⁴	STRING: ENSP00000356070

About this table

Gene Ontology (GO): Selected biological process terms (see all 10): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0002540	leukotriene production involved in inflammatory response	IEA	--
GO:0002675	positive regulation of acute inflammatory response	IEA	--
GO:0006691	leukotriene metabolic process	TAS	--
GO:0019369	arachidonic acid metabolic process	TAS	--
GO:0019370	leukotriene biosynthetic process	IDA	2300173

Find genes that share ontologies with ALOX5AP About GenesLikeMe

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, Sets of similar genes according to GenesLikeMe)
About This Section

Browse Small Molecules at EMD Millipore

Enzo Life Sciences drugs & compounds for ALOX5AP

Browse compounds at ApexBio

Compounds for ALOX5AP available from Tocris Bioscience About this table

Compound	Action	CAS #
BAY-X 1005	Orally active 5-lipoxygenase activating protein (FLAP) inhibitor	[128253-31-6]
BW-B 70C	5-Lipoxygenase inhibitor	[134470-38-5]
Zileuton	Orally active 5-LOX inhibitor	[111406-87-2]
MK 886	Inhibitor of 5-lipoxygenase-activating protein (FLAP)	[118414-82-7]
Baicalein	5- and 12-Lipoxygenase inhibitor	[491-67-8]

Selected Novoseek inferred chemical compound relationships for ALOX5AP gene (see all 31) About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
5-hpete	87.7	5	8344271 (2), 9630716 (1), 7473582 (1)
mk 886	86.6	17	10333477 (4), 11389700 (2), 16817014 (1), 19346216 (1) (see all 10)
ltc4	86.1	63	8703034 (5), 9278457 (4), 9431445 (3), 8052639 (3) (see all 17)
arachidonic acid	82.5	108	8049076 (4), 8440384 (3), 8344271 (3), 10036194 (2) (see all 47)
leukotriene b4	80.9	28	15593193 (3), 9150468 (2), 9609743 (2), 17156456 (2) (see all 19)
zileuton	78.5	5	9609743 (2), 12649539 (1), 18037915 (1), 9113110 (1)
5-hydroxyeicosatetraenoic acid	78.3	6	8358023 (3), 16185917 (1), 11090070 (1)
montelukast	60.8	4	18591367 (1), 19058495 (1), 18037915 (1), 17460547 (1)
pranlukast	58.7	1	19058495 (1)
zafirlukast	55.3	1	19058495 (1)

Find genes that share compounds with ALOX5AP About GenesLikeMe

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
About This Section

REFSEQ mRNAs for ALOX5AP gene (2 alternative transcripts):

NM_001204406.1 NM_001629.3

Unigene Cluster for ALOX5AP:

Arachidonate 5-lipoxygenase-activating protein

Hs.507658 [show with all ESTs]

Unigene Representative Sequence: BU198818

2 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000380490(uc010tdr.2 uc001utf.2) ENST00000479597

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Additional mRNA sequence:

AK314143.1 BC018538.1

13 DOTS entries:

DT.455424 DT.92432935 DT.120780307 DT.92432937 DT.100036052 DT.92045150 DT.95234653 DT.95339664

DT.100036055 DT.100036056 DT.100036057 DT.100705468 DT.95271540

Selected AceView cDNA sequences (see all 167):

AA309930 BQ184220 BQ189456 BX366320 CA310357 CK300333 BU743117 AV713611

BM773521 BM993917 BM992846 CD369422 CK299583 AA353170 BX350312 AV716937

CD370101 CD369702 H02419 BU199063 BQ016999 BQ003388 CA307605 BQ187112

GeneLoc Exon Structure

4 Alternative Splicing Database (ASD) splice patterns (SP) for ALOX5AP About this scheme

ExUns:	1a	·	1b	^	2	^	3a	·	3b	·	3c	^	4	^	5	^	6a	·	6b
SP1:					-		-				-
SP2:											-
SP3:					-		-				-		-		-
SP4:							-

ECgene alternative splicing isoforms for ALOX5AP

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GenesLikeMe, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE ¹MOPED, ²PaxDb, and ³MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

ALOX5AP expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>^2/3
CGAP TAG: TTTTAAGCTG

About this image

ALOX5AP expression in embryonic tissues and stem cells About this table

Data from LifeMap, the Embryonic Development and Stem Cells Database
selected tissues (see all 9) fully expand


Blood (Hematopoietic System) fully expand to see all 2 entries
Granulocytes Peripheral Blood

Thymus (Hematopoietic System)
Thymus

NULL (Uncategorized)
CD31, CD144 positive cells

Bone (Muscoskeletal System)
Bone Marrow

Extraembryonic Mesoderm (Extraembryonic Tissues)
Extraembryonic Angioblasts Extraembryonic Capillary Plexus

ALOX5AP Protein expression data from MOPED¹, PaxDb² and MaxQB³:

About this image

ALOX5AP Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.507658

Custom PCR Arrays for ALOX5AP

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In Situ
Assay Products:

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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for ALOX5AP gene from Selected species (see all 11) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Alox5ap^{1 , 5}	arachidonate 5-lipoxygenase activating protein^{1, 5}	85.71(n)¹ 91.93(a)¹		5 (89.18 cM)⁵ 11690¹ NM_009663.1¹ NP_033793.1¹ 149265058⁵
chicken (Gallus gallus)	Aves	ALOX5AP¹	arachidonate 5-lipoxygenase-activating protein	76.19(n) 82.61(a)		770904 NM_001278144.1 NP_001265073.1
lizard (Anolis carolinensis)	Reptilia	ALOX5AP⁶	arachidonate 5-lipoxygenase-activating protein	72(a)	1 ↔ 1	3(184489477-184505246)
tropical clawed frog (Xenopus tropicalis)	Amphibia	Str.11819²	Transcribed sequence with moderate similarity to protein more	73.55(n)		CF343935.1
zebrafish (Danio rerio)	Actinopterygii	wufj65d02²	wufj65d02	73.41(n)		337376 BC053181.1

ENSEMBL Gene Tree for ALOX5AP (if available)
TreeFam Gene Tree for ALOX5AP (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68,Sets of similar genes according to GenesLikeMe)
About This Section

Paralogs for ALOX5AP gene

LTC4S² MGST2²

2 SIMAP similar genes for ALOX5AP using alignment to 1 protein entry: AL5AP_HUMAN:

LTC4S MGST2

Find genes that share paralogs with ALOX5AP About GenesLikeMe

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, ⁴UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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SNP ID	Valid	Clinical significance	Chr 13 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs17245498^1,2	F	--	12137965(+)	`AACTTC/TTCCCC`	2	--	int¹		4		NS	184
rs61947372^1,2	C,F	--	12234409(+)	`GAGCAG/ACCTCA`	1	--	us2k¹		3		NA WA	240
rs116608419^1,2	C,F	--	12234432(+)	`TTCCAT/GTTTGG`	1	--	us2k¹		1		WA	118
rs144523472^1,2		--	12234597(+)	`ATTGTC/TTCATA`	1	--	us2k¹		0	--	--	--	--
rs77383672^1,2	C,F	--	12234621(+)	`GAAATC/ATGGAA`	1	--	us2k¹		1		NA	2
rs142336688^1,2		--	12234723(+)	`CACTCC/TCATCT`	1	--	us2k¹		0	--	--	--	--
rs34536374^1,2	C,F	--	12234735(+)	`TGCCTC/TCATTG`	1	--	us2k¹		7		NA WA CSA EA	366
rs34344566^1,2	C,F	--	12234737(+)	`CCTCCA/GTTGTC`	1	--	us2k¹		7		NA WA CSA EA	366
rs34352240^1,2	C,F	--	12234746(+)	`TCACAC/TGGCAT`	1	--	us2k¹		8		WA NA CSA EA	368
rs184748028^1,2		--	12234795(+)	`AACATC/TGGTCA`	1	--	us2k¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for ALOX5AP (31287615 - 31338565 bp)

Structural Variations
Database of Genomic Variants (DGV) 3 variations for ALOX5AP: About this table

Variant ID	Type	Subtype	PubMed ID
esv2747225	CNV	Deletion	23290073
nsv984	CNV	Insertion	18451855
nsv832574	CNV	Gain	17160897

Human Gene Mutation Database (HGMD): ALOX5AP
Locus Specific Mutation Databases (LSDB): ALOX5AP

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB, Sets of similar genes according to GenesLikeMe)
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OMIM gene information: 603700
OMIM disorders: 601367
UniProtKB/Swiss-Prot: AL5AP_HUMAN, P20292

Ischemic stroke (ISCHSTR) [MIM:601367]: A stroke is an acute neurologic event leading to death of neural

tissue of the brain and resulting in loss of motor, sensory and/or cognitive function. Ischemic strokes,

resulting from vascular occlusion, is considered to be a highly complex disease consisting of a group of

heterogeneous disorders with multiple genetic and environmental risk factors. Note=Disease susceptibility is

associated with variations affecting the gene represented in this entry

Note=Genetic variations in ALOX5AP may be associated with susceptibility to myocardial infarction.

Involvement in myocardial infarction is however unclear: according to some authors (PubMed:14770184), a 4-SNP

haplotype in ALOX5AP confers risk of myocardial infarction, while according to other (PubMed:17304054) ALOX5AP is

not implicated in this condition

6 diseases for ALOX5AP:
About MalaCards

cerebrovascular disease asthma osteoporosis psoriasis

atherosclerosis familial hypercholesterolemia

1 inferred disease relationship from the University of Copenhagen DISEASES database for ALOX5AP:

Cerebrovascular accident

Find genes that share disorders with ALOX5AP About GenesLikeMe

Selected Novoseek inferred disease relationships for ALOX5AP gene (see all 23) About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
thrombotic stroke	62.7	1	16939001 (1)
asthma	57.7	41	20067482 (6), 15784112 (5), 18547289 (4), 12911785 (4) (see all 14)
stroke	37.8	59	19126581 (4), 15731479 (4), 15640973 (3), 16939001 (3) (see all 20)
myocardial infarction	37.1	33	14770184 (3), 16778124 (3), 16282974 (2), 17176247 (2) (see all 14)
inflammation	37	8	19239910 (2), 16261187 (1), 19759251 (1), 18775537 (1) (see all 7)
cardiovascular diseases	31.5	6	15640973 (2), 16261187 (1), 19239910 (1), 16778124 (1)
atherosclerosis	27.6	5	20376802 (2), 18258817 (1), 15581413 (1), 16278051 (1)
asthma allergic	27.6	1	8994519 (1)
coronary artery disease	16.7	6	19596330 (3), 17505527 (2), 15861005 (1), 18318662 (1)
nephropathy iga	10.1	1	8468935 (1)

Genetic Association Database (GAD): ALOX5AP
Human Genome Epidemiology (HuGE) Navigator: ALOX5AP (69 documents)

Export disorders for ALOX5AP gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for ALOX5AP gene, integrated from 10 sources (see all 263):
(articles sorted by number of sources associating them with ALOX5AP)

Gene characterization and promoter analysis of the human 5- lipoxygenase-activating protein (FLAP). (PubMed id 1673682)^{1, 2, 3, 9} Kennedy B.P.... Dixon R.A.F. (J. Biol. Chem. 1991)
The gene encoding 5-lipoxygenase activating protein confers risk of myocardial infarction and stroke. (PubMed id 14770184)^{1, 2, 4, 9} Helgadottir A.... Stefansson K. (Nat. Genet. 2004)
No association of polymorphisms in the gene encoding 5-lipoxygenase- activating protein and myocardial infarction in a large central European population. (PubMed id 17304054)^{1, 2, 4} Koch W.... Kastrati A. (Genet. Med. 2007)
Genetic variation in the arachidonate 5-lipoxygenase-activating protein (ALOX5AP) is associated with myocardial infarction in the German population. (PubMed id 18318662)^{1, 4, 9} Linsel-Nitschke P....Erdmann J. (Clin. Sci. 2008)
Association of a genetic variant in the ALOX5AP with higher risk of ischemic stroke: a case-control, meta-analysis and functional study. (PubMed id 20357438)^{1, 4, 9} Domingues-Montanari S....Montaner J. (Cerebrovasc. Dis. 2010)
The role of LTA4H and ALOX5AP genes in the risk for asthma in Latinos. (PubMed id 20067482)^{1, 4, 9} Via M....GonzA!lez Burchard E. (Clin. Exp. Allergy 2010)
Arachidonate 5-lipoxygenase-activating protein (ALOX5AP) gene and coronary heart disease risk in familial hypercholesterolemia. (PubMed id 18775537)^{1, 4, 9} van der Net J.B....Sijbrands E.J. (Atherosclerosis 2009)
Variants of the arachidonate 5-lipoxygenase-activating protein (ALOX5AP) gene and risk of stroke: a HuGE gene-disease association review and meta-analysis. (PubMed id 19126581)^{1, 4, 9} Zintzaras E....Sakellaridis N. (Am. J. Epidemiol. 2009)
Polymorphisms in the 5-lipoxygenase activating protein (ALOX5AP) gene are not associated with asthma in an Australian population. (PubMed id 15784112)^{1, 4, 9} Kedda M.A....Thompson P.J. (Clin. Exp. Allergy 2005)
5-lipoxygenase and 5-lipoxygenase-activating protein are localized in the nuclear envelope of activated human leukocytes. (PubMed id 8245774)^{1, 2, 9} Woods J.W.... Singer I.I. (J. Exp. Med. 1993)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 241	HGNC: 436	AceView: ALOX5AP	Ensembl:ENSG00000132965	euGenes: HUgn241
ECgene: ALOX5AP	H-InvDB: ALOX5AP

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for ALOX5AP	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for ALOX5AP	Genetics and Cytogenetics in Oncology and Haematology
SeattleSNPs	http://pga.gs.washington.edu/data/alox5ap/

Intellectual Property for ALOX5AP gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for ALOX5AP gene:
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GeneCards and IP:
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ALOX5AP Gene

Arachidonate 5-Lipoxygenase-Activating Protein

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ALOX5AP Gene

Arachidonate 5-Lipoxygenase-Activating Protein

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