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ALOX5AP Gene

protein-coding GIFtS: 63

GC13P030207

arachidonate 5-lipoxygenase-activating protein
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
FLAP ^¹, ², ³, ⁵
OTTHUMP00000018204 ^²

Descriptions
MK-886-binding protein ^², ³
arachidonate 5-lipoxygenase-activating protein ^²

External Ids
HGNC: 436¹
Entrez Gene: 241²
UniProtKB: P20292³
Ensembl: ENSG00000132965⁷

Search outside databases for aliases for ALOX5AP gene

Previous GC identifers: GC13P029289 GC13P025289 GC13P030239 GC13P029108 GC13P029109

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for ALOX5AP:

This gene encodes a protein which, with 5-lipoxygenase, is required for leukotriene synthesis.

Leukotrienes are arachidonic acid metabolites which have been implicated in various types of

inflammatory responses, including asthma, arthritis and psoriasis. This protein localizes to the

plasma membrane. Inhibitors of its function impede translocation of 5-lipoxygenase from the

cytoplasm to the cell membrane and inhibit 5-lipoxygenase activation. [provided by RefSeq]

UniProtKB/Swiss-Prot: AL5AP_HUMAN, P20292

Function: Required for leukotriene biosynthesis by ALOX5 (5-lipoxygenase). Anchors ALOX5 to the

membrane. Binds arachidonic acid, and could play an essential role in the transfer of arachidonic

acid to ALOX5. Binds to MK-886, a compound that blocks the biosynthesis of leukotrienes

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the ALOX5AP gene

Entrez Gene cytogenetic band: 13q12 Ensembl cytogenetic band: 13q12.3 HGNC cytogenetic band: 13q12

ALOX5AP Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 13 GeneLoc Exon Structure

GeneLoc location for GC13P030207: (about GC identifiers)

Start:	30,207,669 bp from pter
End:	30,236,556 bp from pter
Size:	28,888 bases
Orientation:	plus strand

RefSeq DNA sequence:

NC_000013.9 NT_024524.13

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: AL5AP_HUMAN, P20292 (See protein sequence)

Recommended Name: Arachidonate 5-lipoxygenase-activating protein

Size: 161 amino acids; 18157 Da

Subunit: Homotrimer. Interacts with LTC4S and ALOX5

Subcellular location: Nucleus membrane; Multi-pass membrane protein. Endoplasmic reticulum

membrane; Multi-pass membrane protein

PDB structure from and Proteopedia :

2Q7M (3D)

2Q7R (3D)

Secondary accessions: Q5VV04

REFSEQ proteins: NP_001620.2

ENSEMBL proteins:

ENSP00000369858

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (FLAP)
	Human Recombinant Proteins from Abnova (ALOX5AP)

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

2 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0016020	membrane	IEA	--
GO:0016021	integral to membrane	IEA	--

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Antibodies for ALOX5AP:

	Browse Antibodies Central at Invitrogen
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Sigma-Aldrich Antibodies for ALOX5AP
	Browse R&D Systems for Antibodies
	Antibodies from Abcam (FLAP), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (ALOX5AP)
	Novus Biologicals Antibodies for ALOX5AP

Assays for ALOX5AP:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry P20292

ProtoNet protein and cluster: P20292

2 Blocks protein families:

IPB001129 Membrane-associated proteins in eicosanoid and glutathione metabolism (MAPEG)

IPB001446 Five-lipoxygenase activating protein signature

UniProtKB/Swiss-Prot: AL5AP_HUMAN, P20292

Domain: The C-terminal part after residue 140 is mostly unstructured

Similarity: Belongs to the MAPEG family

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (ALOX5AP)
		Browse for Gene Knock-down Tools from Millipore
		Browse Abnova for Chimera RNAi Products

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_001629

Applied Biosystems Silencer® siRNAs for ALOX5AP

Sigma-Aldrich siRNA and siRNA Panels for ALOX5AP

Sigma-Aldrich shRNA for ALOX5AP

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for ALOX5AP
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_001629
Myc/DDK tagged cDNA clone in CMV expression vector: NM_001629
untagged cDNA clone in CMV expression vector: NM_001629

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_001629

UniProtKB/Swiss-Prot: AL5AP_HUMAN, P20292

Function: Required for leukotriene biosynthesis by ALOX5 (5-lipoxygenase). Anchors ALOX5 to the

membrane. Binds arachidonic acid, and could play an essential role in the transfer of arachidonic

acid to ALOX5. Binds to MK-886, a compound that blocks the biosynthesis of leukotrienes

Genatlas biochemistry entry for ALOX5AP:

arachidonate 5-lipoxygenase activating protein,expressed in cells of myeloid origin,localized in

the nuclear envelop,involved in the biosynthesis of leukotrienes (role in

inflammation),microsomal,GST superfamily

3 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Alox5ap):

immune system

skeleton

2 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005488	binding	TAS	2300173
GO:0008047	enzyme activator activity	TAS	2300173

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

1 Sigma-Aldrich "Your Favorite Gene" Pathway for ALOX5AP (Your Favorite Gene powered by Ingenuity)

Eicosanoid Signaling

GeneDecks ALOX5AP for the pathways selected above

About GeneDecksing

Gene Network Central^TM Interacting Genes and Proteins Network for ALOX5AP

5/20 Interacting proteins for ALOX5AP (ENSP00000369858³) via UniProtKB, MINT, and/or STRING (see all 20 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
ALOX5	ENSP00000363512³	STRING (score=.996)
LTA4H	ENSP00000228740³	STRING (score=.979)
MGST3	ENSP00000356860³	STRING (score=.949)
MGST1	ENSP00000010404³	STRING (score=.93)
ALOX12	ENSP00000251535³	STRING (score=.922)

About this table

2 Gene Ontology (GO) biological process terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006954	inflammatory response	TAS	2300173
GO:0019370	leukotriene biosynthetic process	IEA	--

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Sigma-Aldrich Small Molecules for ALOX5AP:

Inhibitor

Compounds for ALOX5AP available from Tocris Bioscience

Compound	Action	CAS number
MK 886	Inhibitor of 5-lipoxygenase-activating protein (FLAP)	[118414-82-7]

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10/16 Novoseek chemical compound relationships for ALOX5AP gene (see all 16 )

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
5-hpete	88.51	5	8344271 (2), 9630716 (1), 7473582 (1)
ltc4	86.45	62	8703034 (5), 9278457 (4), 9431445 (3), 8052639 (3) (see all 16)
arachidonic acid	82.41	101	8049076 (4), 8440384 (3), 8344271 (3), 10036194 (2) (see all 43)
leukotriene b4	80.88	24	15593193 (3), 9150468 (2), 9609743 (2), 10079010 (2) (see all 16)
5-hydroxyeicosatetraenoic acid	79.41	6	8358023 (3), 16185917 (1), 11090070 (1)
quinoline	51.11	8	1857337 (3), 8043028 (1), 8031320 (1)
12-hydroxyeicosatetraenoic acid	42.15	1	10588925 (1)
indole	40.09	9	1857337 (4), 15953724 (1), 9197987 (1)
1,25 dihydroxy vitamin d3	26.17	5	8380989 (2), 15593193 (1), 17156456 (1)
linoleic acid	21.19	1	9630716 (1)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (ALOX5AP)
		Browse for Gene Knock-down Tools from Millipore
		Browse Abnova for Chimera RNAi Products

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_001629

Sigma-Aldrich siRNA and siRNA Panels for ALOX5AP

Sigma-Aldrich shRNA for ALOX5AP

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_001629

REFSEQ mRNAs for ALOX5AP gene:

NM_001629.2

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_001629

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_001629
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_001629
                                 untagged cDNA clone in CMV expression vector: NM_001629

Additional cDNA sequence:

AK314143.1 BC018538.1

14 DOTS entries:

DT.455424 DT.92432935 DT.120780307 DT.95150282 DT.92045150 DT.92432937 DT.100036052 DT.95234653

DT.95339664 DT.100036055 DT.100036056 DT.100036057 DT.100705468 DT.95271540

24/167 AceView cDNA sequences (see all 167 ):

CD369702 CD370101 CA306377 CD369422 AA353170 CA307605 BQ187112 BM993240

BM992846 BM725948 BX350312 AV716674 BM823620 NM_001629 BQ003388 BQ189456

AV713611 BQ184220 H02419 AA309930 CA310357 BQ016999 BX366320 BU199063

highest scoring ESTs for ALOX5AP:

AI806222 AI983204 AA309930 AA344636 AA565102 AA631666 AA677100 AA746329 AA975898 AI247526

Unigene Cluster for ALOX5AP:

Arachidonate 5-lipoxygenase-activating protein

Hs.507658 [show with all ESTs]

Unigene Representative Sequence: BU198818

GeneLoc Exon Structure

4 Alternative Splicing Database (ASD) splice patterns (SP) for ALOX5AP

ExUns:	1a	·	1b	^	2	^	3a	·	3b	·	3c	^	4	^	5	^	6a	·	6b
SP1:					-		-				-
SP2:											-
SP3:					-		-				-		-		-
SP4:							-

About this scheme

ECgene alternative splicing isoforms for ALOX5AP

1 Ensembl transcript including schematic representation:

ENST00000380490

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

ALOX5AP expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for ALOX5AP

¹ / ² / ³

4 probe-sets matching ALOX5AP gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
37099_at²^{, 3}	U95-A	1	1.00	1.00	1.00	0.86	AI806222	1.00	1.00	1.00	1
60061_at²^{, 3}	U95-C	1	1.00	1.00	1.00	1.14	AI983204	1.00	1.00	1.00	1
204174_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_001629	0.60	1.00	0.82	1
204174_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

GeneDecks ALOX5AP for binary patterns associated with the probe-sets selected above

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Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: TTTTAAGCTG

SOURCE GeneReport for Unigene cluster: Hs.507658
Expression variation in blood from EXPOLDB for ALOX5AP

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for ALOX5AP gene from 5/8 species (see all 8 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	ALOX5AP¹	--	arachidonate 5-lipoxygenase-activating protein	90.48(n) 96.27(a)	477323 XM_534516.2 XP_534516.2
chimpanzee (Pan troglodytes)	ALOX5AP¹	--	arachidonate 5-lipoxygenase-activating protein	99.17(n) 100(a)	452520 XM_001141625.1 XP_001141625.1
cow (Bos taurus)	ALOX5AP¹	--	arachidonate 5-lipoxygenase-activating protein	86.13(n) 90.68(a)	613869 NM_001076293.1 NP_001069761.1
rat (Rattus norvegicus)	Alox5ap¹	--	arachidonate 5-lipoxygenase activating protein	85.09(n) 91.93(a)	29624 NM_017260.2 NP_058956.1
mouse (Mus musculus)	Alox5ap^{1, 5}	5⁵	arachidonate 5-lipoxygenase activating protein^{1, 5}	85.71(n)¹ 91.93(a)¹	11690¹ NM_009663.1¹ NP_033793.1¹ AA930477⁵ AK004002⁵ (see all 9)

About this table Species with no ortholog for ALOX5AP

ENSEMBL Gene Tree for ALOX5AP

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for ALOX5AP gene

LTC4S² MGST2²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/295 NCBI SNPs in ALOX5AP are shown (see all 295 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 157)

AB	SNP ID	Valid	Chr 13 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--				--
--	rs9604625^1,2	A,C,F,H	30236956(-)	`tttttT/Aaattt`	1	--	ng3¹		8		EU EA WA NS	606
	rs1132340^1,2	C,F,H	30236462(+)	`TTCCCA/GTGCAT`	1	--	ut3¹ ese³		12		NS NA EU EA WA	794
--	rs17245379^1,2	C,F	30236797(+)	`AATACA/GAAAAT`	1	--	ng3¹		4		NS	188
--	rs9315042^1,2	C,F	30206652(+)	`TTTCCA/TTGTAA`	1	--	ng5¹		7		NS NA	324
	rs9550373^1,2	A,H	30207404(-)	`CAGCAC/TGAGCC`	1	--	ng5¹		4		EU EA WA	406
--	rs17222919^1,2	C,F	30206329(+)	`GGTACT/GCAGGG`	1	--	ng5¹		11		EU NS	3656
	rs3809376^1,2	F,H	30206722(+)	`CCCACC/ACAGCA`	1	--	ng5¹		4		EU EA WA	416
--	rs9670503^1,2	C	30207251(+)	`CAAGCA/GATCTT`	1	--	ng5¹		0	--	--	--	--
	rs9670115^1,2	H	30205894(+)	`aaaagC/Ggggca`	1	--	ng5¹		4		EU EA WA	420
--	rs17244967^1,2	F	30206258(+)	`ATTTAT/CATATT`	1	--	ng5¹		4		NS	188

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HapMap Linkage Disequilibrium images for ALOX5AP (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 603700 disorders: 601367

UniProtKB/Swiss-Prot: AL5AP_HUMAN, P20292

Genetic variations in ALOX5AP may be a cause of susceptibility to ischemic stroke

[MIM:601367]; also known as cerebrovascular accident or cerebral infarction. A stroke is an acute

neurologic event leading to death of neural tissue of the brain and resulting in loss of motor,

sensory and/or cognitive function. Ischemic strokes, resulting from vascular occlusion, is

considered to be a highly complex disease consisting of a group of heterogeneous disorders with

multiple genetic and environmental risk factors

Haplotypes HapA and HapB are associated with susceptibility to myocardial infarction

[MIM:608557]

10/23 Novoseek disease relationships for ALOX5AP gene (see all 23 )

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
thrombotic stroke	64.58	1	16939001 (1)
asthma	55.52	29	15784112 (5), 18547289 (4), 12911785 (4), 8994519 (2) (see all 10)
stroke	34.87	52	19126581 (4), 15731479 (4), 15640973 (3), 16635437 (3) (see all 16)
inflammation	33.50	7	19239910 (2), 16261187 (1), 18779380 (1), 9445303 (1) (see all 6)
asthma allergic	30.70	1	8994519 (1)
myocardial infarction	28.38	30	14770184 (3), 16778124 (3), 16282974 (2), 18318662 (2) (see all 12)
cardiovascular diseases	22.36	6	15640973 (2), 16261187 (1), 19239910 (1), 16778124 (1)
atherosclerosis	20.09	3	18258817 (1), 15581413 (1), 16278051 (1)
coronary artery disease	16.09	3	17505527 (2), 15861005 (1), 18318662 (1)
nephropathy iga	12.97	1	8468935 (1)

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2 PharmGKB disease relationships for ALOX5AP gene

Disease	PharmGKB Relations	PubMed IDs for articles supporting these relationships
Leukemia, Lymphocytic, Acute, L1	FA GN	12086872 12730115
Myocardial Infarction	GN	14770184

About this table

Human Gene Mutation Database: ALOX5AP
Genetic Association Database: ALOX5AP
Human Genome Epidemiology Navigator: ALOX5AP (43 documents)

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/207 PubMed articles for ALOX5AP gene (see all 207 ):

The gene encoding 5-lipoxygenase activating protein confers risk of myocardial infarction and stroke. (PubMed id 14770184)^{1, 3, 4, 6, 7} Helgadottir A.... Stefansson K. (2004)
Gene characterization and promoter analysis of the human 5- lipoxygenase-activating protein (FLAP). (PubMed id 1673682)^{1, 2, 3, 4} Kennedy B.P.... Dixon R.A.F. (1991)
Polymorphisms in the 5-lipoxygenase activating protein (ALOX5AP) gene are not associated with asthma in an Australian population. (PubMed id 15784112)^{1, 3, 6} Kedda M.A....Thompson P.J. (2005)
Cytogenetic and radiation hybrid mapping of human arachidonate 5-lipoxygenase-activating protein (ALOX5AP) to chromosome 13q12. (PubMed id 10036194)^{1, 2, 3} Yandava C.N....Drazen J.M. (1999)
Effects of a 5-lipoxygenase-activating protein inhibitor on biomarkers associated with risk of myocardial infarction: a randomized trial. (PubMed id 15886380)^{1, 3, 6} Hakonarson H....Stefansson K. (2005)
ALOX5AP gene and the PDE4D gene in a central European population of stroke patients. (PubMed id 15731479)^{1, 3, 6} Lohmussaar E....Dichgans M. (2005)
Promoter polymorphism in the 5-lipoxygenase (ALOX5) and 5-lipoxygenase-activating protein (ALOX5AP) genes and asthma susceptibility in a Caucasian population. (PubMed id 12911785)^{1, 3, 6} Sayers I....Holgate S.T. (2003)
5-lipoxygenase-activating protein is an arachidonate binding protein. (PubMed id 8440384)^{1, 3, 4} Mancini J.A....Vickers P.J. (1993)
Distinct parts of leukotriene C(4) synthase interact with 5-lipoxygenase and 5-lipoxygenase activating protein. (PubMed id 19233132)^{1, 3, 4} Strid T....HammarstrAPm S. (2009)
A variant of the gene encoding leukotriene A4 hydrolase confers ethnicity-specific risk of myocardial infarction. (PubMed id 16282974)^{1, 3, 6} Helgadottir A....Stefansson K. (2006)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 241	HGNC: 436	AceView: ALOX5AP	Ensembl:ENSG00000132965	euGenes: HUgn241
ECgene: ALOX5AP	H-InvDB: ALOX5AP

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
ATLAS Chromosomes in Cancer entry for ALOX5AP	Genetics and Cytogenetics in Oncology and Haematology
SeattleSNPs	http://pga.gs.washington.edu/data/alox5ap/

Licensable Technologies for ALOX5AP
(Available from WIS Yeda, Salk, Tufts)

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(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for ALOX5AP:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for ALOX5AP-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for ALOX5AP		Antibodies for ALOX5AP
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for ALOX5AP		Small molecules for ALOX5AP
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Recombinant Proteins (ALOX5AP)
	Antibodies (ALOX5AP)
	Search for Chimera RNAi
	Custom Service for Mouse Mab
	Custom Service for Rabbit Pab from Full-length Protein

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	Recombinant Proteins (FLAP)
	Antibodies (FLAP)

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Tocris compounds for ALOX5AP

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Antibodies for ALOX5AP

GeneCards Homepage - Last full update: 2 Jul 2009 Incremental update: 13 Oct 2009

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Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

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ALOX5AP Gene at Home site.
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ALOX5AP Gene

protein-coding GIFtS: 63

Aliases &
Descriptions
for ALOX5AP

Summaries
for ALOX5AP

Genomic Location
for ALOX5AP

Proteins
for ALOX5AP

Protein Domains/
Families
for ALOX5AP

Gene Function
for ALOX5AP

Pathways & Interactions
for ALOX5AP

Drugs & Compounds
for ALOX5AP

Transcripts
for ALOX5AP

Expression
for ALOX5AP

Orthologs
for ALOX5AP

Paralogs
for ALOX5AP

SNPs/Variants
for ALOX5AP

Disorders & Mutations
for ALOX5AP

Medical News
for ALOX5AP

Publications
for ALOX5AP

Search for ALOX5AP

Genome Databases showing ALOX5AP

Other Databases showing ALOX5AP

Specialized Databases showing ALOX5AP

Licensable Technologies
for ALOX5AP

Services
for ALOX5AP

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

ALOX5AP Gene

protein-coding GIFtS: 63

Aliases & Descriptionsfor ALOX5AP

Summariesfor ALOX5AP

Genomic Locationfor ALOX5AP

Proteinsfor ALOX5AP

Protein Domains/Familiesfor ALOX5AP

Gene Functionfor ALOX5AP

Pathways & Interactionsfor ALOX5AP

Drugs & Compoundsfor ALOX5AP

Transcriptsfor ALOX5AP

Expression for ALOX5AP

Orthologsfor ALOX5AP

Paralogsfor ALOX5AP

SNPs/Variantsfor ALOX5AP

Disorders & Mutationsfor ALOX5AP

Medical Newsfor ALOX5AP

Publicationsfor ALOX5AP

Search for ALOX5AP

Genome Databases showing ALOX5AP

Other Databases showing ALOX5AP

Specialized Databases showing ALOX5AP

Licensable Technologiesfor ALOX5AP

Servicesfor ALOX5AP

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for ALOX5AP

Summaries
for ALOX5AP

Genomic Location
for ALOX5AP

Proteins
for ALOX5AP

Protein Domains/
Families
for ALOX5AP

Gene Function
for ALOX5AP

Pathways & Interactions
for ALOX5AP

Drugs & Compounds
for ALOX5AP

Transcripts
for ALOX5AP

Expression
for ALOX5AP

Orthologs
for ALOX5AP

Paralogs
for ALOX5AP

SNPs/Variants
for ALOX5AP

Disorders & Mutations
for ALOX5AP

Medical News
for ALOX5AP

Publications
for ALOX5AP

Licensable Technologies
for ALOX5AP

Services
for ALOX5AP