Aliases for ALOX5AP Gene
Aliases for ALOX5AP Gene
External Ids for ALOX5AP Gene
- HGNC: 436
- Entrez Gene: 241
- Ensembl: ENSG00000132965
- OMIM: 603700
- UniProtKB: P20292
Previous GeneCards Identifiers for ALOX5AP Gene
- GC13P029289
- GC13P025289
- GC13P030239
- GC13P029108
- GC13P029109
- GC13P030207
- GC13P031309
- GC13P012127
Summaries for ALOX5AP Gene
-
This gene encodes a protein which, with 5-lipoxygenase, is required for leukotriene synthesis. Leukotrienes are arachidonic acid metabolites which have been implicated in various types of inflammatory responses, including asthma, arthritis and psoriasis. This protein localizes to the plasma membrane. Inhibitors of its function impede translocation of 5-lipoxygenase from the cytoplasm to the cell membrane and inhibit 5-lipoxygenase activation. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Feb 2011]
GeneCards Summary for ALOX5AP Gene
ALOX5AP (Arachidonate 5-Lipoxygenase Activating Protein) is a Protein Coding gene. Diseases associated with ALOX5AP include Stroke, Ischemic and Myocardial Infarction. Among its related pathways are Arachidonic acid metabolism and Metabolism. Gene Ontology (GO) annotations related to this gene include protein homodimerization activity and enzyme binding. An important paralog of this gene is MGST2.
UniProtKB/Swiss-Prot for ALOX5AP Gene
-
Required for leukotriene biosynthesis by ALOX5 (5-lipoxygenase). Anchors ALOX5 to the membrane. Binds arachidonic acid, and could play an essential role in the transfer of arachidonic acid to ALOX5. Binds to MK-886, a compound that blocks the biosynthesis of leukotrienes.
-
Lipoxygenases (LOXs) are a family of non-heme iron dioxygenases that are involved in the production and metabolism of fatty acid hydroperoxidases. There are six lipoxygenase isozymes; 5-LOX, 12R-LOX, 12S-LOX, 15-LOX-1, 15-LOX-2 and E-LOX.
Additional gene information for ALOX5AP Gene
- Monarch Initiative
- Search for ALOX5AP at DataMed
- Search for ALOX5AP at HumanCyc
No data available for CIViC summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ALOX5AP Gene
Genomics for ALOX5AP Gene
GeneHancer (GH) Regulatory Elements for ALOX5AP Gene
Promoters and enhancers for ALOX5AP Gene
| GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
|---|---|---|---|---|---|---|---|---|---|---|
| GH13I030734 | Promoter/Enhancer | 2 | EPDnew FANTOM5 Ensembl ENCODE dbSUPER | 607.7 | +24.2 | 24173 | 7.1 | HDGF PKNOX1 BMI1 BATF IRF4 EGR1 SCRT2 ATF7 ETV6 FOS | ALOX5AP USPL1 LINC00398 | |
| GH13I030712 | Promoter/Enhancer | 1.4 | EPDnew Ensembl ENCODE | 550.8 | -0.2 | -208 | 1.5 | CTCF PKNOX1 JUN MAX POLR2A ZSCAN29 ETV6 FOS CREM CEBPB | ALOX5AP ENSG00000275788 | |
| GH13I030714 | Enhancer | 0.5 | FANTOM5 Ensembl | 599.2 | +1.5 | 1518 | 0.8 | ALOX5AP USPL1 HMGB1 LINC00398 | ||
| GH13I030742 | Enhancer | 1.6 | FANTOM5 Ensembl ENCODE dbSUPER | 38.9 | +31.8 | 31843 | 6 | PKNOX1 CLOCK NEUROD1 SIN3A IRF4 YY1 ZNF143 ATF7 FOS RUNX3 | ALOX5AP HMGB1 USPL1 LINC00398 | |
| GH13I030689 | Enhancer | 1.1 | FANTOM5 Ensembl ENCODE | 17.8 | -23.0 | -22963 | 2 | TFAP4 USF2 SIN3A MAX ZBTB5 GABPA SP1 CTBP1 POLR2A GLIS1 | ALOX5AP MEDAG USPL1 ENSG00000275788 |
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data dump
GeneHancers around ALOX5AP on UCSC Golden Path with GeneCards custom track
- Top Transcription factor binding sites by QIAGEN in the ALOX5AP gene promoter:
Regulatory Element Products
Genomic Locations for ALOX5AP Gene
Genomic Locations for ALOX5AP Gene
- chr13:30,713,478-30,764,428
- (GRCh38/hg38)
- Size:
- 50,951 bases
- Orientation:
- Plus strand
- chr13:31,287,615-31,338,565
- (GRCh37/hg19)
Genomic View for ALOX5AP Gene
Genes around ALOX5AP on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 13q12.3 by Ensembl
- 13q12.3 by Entrez Gene
- 13q12.3 by HGNC
ALOX5AP Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for ALOX5AP Gene
Proteins for ALOX5AP Gene
-
Protein details for ALOX5AP Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P20292-AL5AP_HUMAN
- Recommended name:
- Arachidonate 5-lipoxygenase-activating protein
- Protein Accession:
- P20292
- Q5VV04
Protein attributes for ALOX5AP Gene
- Size:
- 161 amino acids
- Molecular mass:
- 18157 Da
- Quaternary structure:
-
- Homotrimer. Interacts with LTC4S and ALOX5.
Protein Expression for ALOX5AP Gene
Post-translational modifications for ALOX5AP Gene
No Post-translational modifications
Other Protein References for ALOX5AP Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
-
Custom Antibody ServicesOriGene Antibodies for ALOX5AP
- Novus Biologicals Antibodies for ALOX5AP
-
Abcam antibodies for ALOX5AP
- Invitrogen Antibodies for ALOX5AP
- GeneTex ALOX5AP antibody for ALOX5AP
- Sino Biological Antibodies for ALOX5AP
Protein Products
-
OriGene Purified Proteins for ALOX5AP
- Search Origene for MassSpec and Protein Over-expression Lysates for ALOX5AP
- Origene Custom Protein Services for ALOX5AP
- Sino Biological Cell Lysates for ALOX5AP
- Sino Biological Recombinant Proteins for ALOX5AP
- antibodies-online: Search results for 5 available ALOX5AP Proteins ranked by validation data
- Compare Top ALOX5AP Proteins
-
Quality Products:
- Search GeneTex for Proteins for ALOX5AP
-
Abcam proteins for ALOX5AP
Assay Products
- antibodies-online: Search results for 8 available ALOX5AP Elisa Kits ranked by validation data
- Compare Top ALOX5AP Elisa Kits
-
Quality Products:
No data available for DME Specific Peptides for ALOX5AP Gene
Domains & Families for ALOX5AP Gene
Gene Families for ALOX5AP Gene
- Human Protein Atlas (HPA):
-
- Disease related genes
- Predicted membrane proteins
Protein Domains for ALOX5AP Gene
Suggested Antigen Peptide Sequences for ALOX5AP Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
P20292UniProtKB/Swiss-Prot:
AL5AP_HUMAN :- The C-terminal part after residue 140 is mostly unstructured.
- Belongs to the MAPEG family.
- Domain:
-
- The C-terminal part after residue 140 is mostly unstructured.
- Family:
-
- Belongs to the MAPEG family.
Function for ALOX5AP Gene
Molecular function for ALOX5AP Gene
- GENATLAS Biochemistry:
- arachidonate 5-lipoxygenase activating protein,expressed in cells of myeloid origin,localized in the nuclear envelop,involved in the biosynthesis of leukotrienes (role in inflammation),microsomal,GST superfamily
- UniProtKB/Swiss-Prot Function:
- Required for leukotriene biosynthesis by ALOX5 (5-lipoxygenase). Anchors ALOX5 to the membrane. Binds arachidonic acid, and could play an essential role in the transfer of arachidonic acid to ALOX5. Binds to MK-886, a compound that blocks the biosynthesis of leukotrienes.
Phenotypes From GWAS Catalog for ALOX5AP Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0004051 | arachidonate 5-lipoxygenase activity | IEA | -- |
| GO:0004364 | NOT glutathione transferase activity | IBA | -- |
| GO:0004464 | NOT leukotriene-C4 synthase activity | IBA | -- |
| GO:0004602 | NOT glutathione peroxidase activity | IBA | -- |
| GO:0005515 | protein binding | IPI | 19233132 |
Phenotypes for ALOX5AP Gene
- MGI mutant phenotypes for ALOX5AP:
- inferred from 2 alleles
- GenomeRNAi human phenotypes for ALOX5AP:
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for ALOX5AP
-
-
ViGene Biosciences lentiviral particle packaged cDNA for ALOX5AP gene
-
ViGene Biosciences ready-to-package AAV shRNAs for ALOX5AP gene
- Search ViGene Biosciences for ALOX5AP
CRISPR Products
-
OriGene CRISPR knockouts for ALOX5AP
- genomics-online: gRNA clones - Search results for 120 available ALOX5AP gene related products
- Overview of 120 available ALOX5AP gene related products
- Applied Biological Materials CRISPR for ALOX5AP
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for ALOX5AP
- GenScript: Design CRISPR guide RNA sequences for ALOX5AP
miRNA for ALOX5AP Gene
- miRTarBase miRNAs that target ALOX5AP
-
- hsa-mir-3149 (MIRT515803)
- hsa-mir-4775 (MIRT515804)
- hsa-mir-664a-5p (MIRT515805)
- hsa-mir-4794 (MIRT515806)
- hsa-mir-4735-5p (MIRT515807)
- hsa-mir-338-3p (MIRT515808)
- hsa-mir-7851-3p (MIRT515809)
- hsa-mir-619-3p (MIRT515810)
- hsa-mir-634 (MIRT515811)
- hsa-mir-590-3p (MIRT515812)
- hsa-mir-122-5p (MIRT761311)
- hsa-mir-1267 (MIRT761749)
- hsa-mir-1304-3p (MIRT762406)
- hsa-mir-143-5p (MIRT762662)
- hsa-mir-24-3p (MIRT764049)
- hsa-mir-3135b (MIRT764908)
- hsa-mir-320e (MIRT765543)
- hsa-mir-3622b-5p (MIRT766157)
- hsa-mir-3664-5p (MIRT766493)
- hsa-mir-367-5p (MIRT766703)
- hsa-mir-4284 (MIRT768375)
- hsa-mir-4423-5p (MIRT768852)
- hsa-mir-4639-3p (MIRT770536)
- hsa-mir-504-3p (MIRT773030)
- hsa-mir-5693 (MIRT775023)
- hsa-mir-5698 (MIRT775135)
- hsa-mir-6499-3p (MIRT776189)
- hsa-mir-6501-5p (MIRT776516)
- hsa-mir-6794-3p (MIRT779324)
- hsa-mir-6890-3p (MIRT781133)
- hsa-mir-744-3p (MIRT781706)
- hsa-mir-8057 (MIRT782321)
miRNA Products
- Search ViGene Biosciences for ALOX5AP
Inhibitory RNA Products
- Origene RNAi and shrna products in human, mouse, rat for ALOX5AP
- Browse OriGene Inhibitory RNA Products For ALOX5AP
- genomics-online: shRNA clones - Search results for 120 available ALOX5AP gene related products
- Overview of 120 available ALOX5AP gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for ALOX5AP gene
Clone Products
- Sino Biological Human cDNA Clone for ALOX5AP
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for ALOX5AP
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for ALOX5AP
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Applied Biological Materials Clones for ALOX5AP
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
-
Horizon Cell Lines for ALOX5AP
-
ViGene Biosciences adenoviral particle packaged cDNA for ALOX5AP gene
-
ViGene Biosciences lentiviral particle packaged cDNA for ALOX5AP gene
-
ViGene Biosciences ready-to-package AAV shRNAs for ALOX5AP gene
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ALOX5AP Gene
Localization for ALOX5AP Gene
Subcellular locations from UniProtKB/Swiss-Prot for ALOX5AP Gene
- Nucleus membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein.
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| endoplasmic reticulum | 5 |
| plasma membrane | 2 |
| lysosome | 2 |
| extracellular | 1 |
| cytosol | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005634 | nucleus | IEA | -- |
| GO:0005635 | nuclear envelope | TAS,IEA | -- |
| GO:0005783 | endoplasmic reticulum | IDA,IEA | 19233132 |
| GO:0005789 | endoplasmic reticulum membrane | IEA | -- |
| GO:0005829 | cytosol | IEA | -- |
No data available for Subcellular locations from the Human Protein Atlas (HPA) for ALOX5AP Gene
Pathways & Interactions for ALOX5AP Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Arachidonic acid metabolism | ||
| 2 | Metabolism |
.37
|
|
| 3 | Immune response Fc epsilon RI pathway | ||
| 4 | Leukotriene modifiers pathway, Pharmacodynamics | ||
| 5 | Eicosanoid Synthesis | ||
Pathways by source for ALOX5AP Gene
2 BioSystems pathways for ALOX5AP Gene
6 Reactome pathways for ALOX5AP Gene
1 PharmGKB pathway for ALOX5AP Gene
1 KEGG pathway for ALOX5AP Gene
Interacting Proteins for ALOX5AP Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0002675 | positive regulation of acute inflammatory response | IEA | -- |
| GO:0006691 | leukotriene metabolic process | IEA,TAS | -- |
| GO:0019370 | leukotriene biosynthetic process | IDA,IEA | 2300173 |
| GO:0019372 | lipoxygenase pathway | TAS,IEA | -- |
| GO:0043085 | positive regulation of catalytic activity | IEA | -- |
No data available for SIGNOR curated interactions for ALOX5AP Gene
Drugs & Compounds for ALOX5AP Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| Zileuton | Approved, Investigational, Withdrawn | Pharma | Inhibition, Inhibitor | 5-lipoxygenase (5-LOX) inhibitor, orally active | 20 | |
| DG031 | Investigational | Pharma | Target, inhibitor | 0 | ||
| AM103 | Investigational | Pharma | Target | 0 | ||
| MK 886 | Pharma | Inhibitor of 5-lipoxygenase-activating protein (FLAP) | 0 | |||
| AM679 | Pharma | FLAP inhibitor | 0 |
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs |
|---|
(5) Tocris Compounds for ALOX5AP Gene
| Compound | Action | Cas Number |
|---|---|---|
| 2-TEDC | 5-, 12-, 15-Lipoxygenase inhibitor | 132465-10-2 |
| Baicalein | 5- and 12-Lipoxygenase inhibitor | 491-67-8 |
| BAY-X 1005 | Orally active 5-lipoxygenase activating protein (FLAP) inhibitor | 128253-31-6 |
| BW-B 70C | 5-Lipoxygenase inhibitor | 134470-38-5 |
| MK 886 | Inhibitor of 5-lipoxygenase-activating protein (FLAP) | 118414-82-7 |
(6) ApexBio Compounds for ALOX5AP Gene
| Compound | Action | Cas Number |
|---|---|---|
| AM679 | FLAP inhibitor | 1206880-66-1 |
| GSK2190915 sodium salt | 1196070-26-4 | |
| Malotilate | Tyrosine kinase inhibitors | 59937-28-9 |
| MK-0591 | FLAP inhibitor,potent and selective | 136668-42-3 |
| MK591 | FLAP inhibitor,potent and selective | 147030-01-1 |
| Zileuton | 5-lipoxygenase (5-LOX) inhibitor, orally active | 111406-87-2 |
Transcripts for ALOX5AP Gene
mRNA/cDNA for ALOX5AP Gene
- (3) REFSEQ mRNAs :
- (2) Additional mRNA sequences :
- (167) Selected AceView cDNA sequences:
- (3) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for ALOX5AP Gene
CRISPR Products
-
OriGene CRISPR knockouts for ALOX5AP
- genomics-online: gRNA clones - Search results for 120 available ALOX5AP gene related products
- Overview of 120 available ALOX5AP gene related products
- Applied Biological Materials CRISPR for ALOX5AP
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for ALOX5AP
- GenScript: Design CRISPR guide RNA sequences for ALOX5AP
miRNA Products
- Search ViGene Biosciences for ALOX5AP
Inhibitory RNA Products
- Origene RNAi and shrna products in human, mouse, rat for ALOX5AP
- Browse OriGene Inhibitory RNA Products For ALOX5AP
- genomics-online: shRNA clones - Search results for 120 available ALOX5AP gene related products
- Overview of 120 available ALOX5AP gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for ALOX5AP gene
Clone Products
- Sino Biological Human cDNA Clone for ALOX5AP
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for ALOX5AP
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for ALOX5AP
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Applied Biological Materials Clones for ALOX5AP
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3a | · | 3b | · | 3c | ^ | 4 | ^ | 5 | ^ | 6a | · | 6b |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | ||||||||||||||||
| SP2: | - | ||||||||||||||||||
| SP3: | - | - | - | - | - | ||||||||||||||
| SP4: | - |
Expression for ALOX5AP Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Blood (Hematopoietic System)
- Granulocytes Peripheral Blood
- Plasmacytoid Dendritic cells Peripheral Blood
-
Extraembryonic Mesoderm (Extraembryonic Tissues)
- Extraembryonic Angioblasts Extraembryonic Capillary Plexus
-
Endothelium (Cardiovascular System)
- Extraembryonic Angioblasts Extraembryonic Capillary Plexus
- Bone (Muscoskeletal System)
- Liver (Hepatobiliary System)
- Thymus (Hematopoietic System)
- NULL (Uncategorized)
-
Spleen (Hematopoietic System)
-
Lung (Respiratory System)
mRNA differential expression in normal tissues according to GTEx for ALOX5AP Gene
This gene is overexpressed in Whole Blood (x40.3).
This gene is overexpressed in Nasal epithelium (37.5).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for ALOX5AP Gene
- Elite partner
NURSA nuclear receptor signaling pathways regulating expression of ALOX5AP Gene:
ALOX5APSOURCE GeneReport for Unigene cluster for ALOX5AP Gene:
Hs.507658Evidence on tissue expression from TISSUES for ALOX5AP Gene
- Blood(3.1)
- Lung(2.6)
- Bone marrow(2.2)
- Spleen(2.1)
- Nervous system(2)
Primer Products
-
OriGene qPCR primer pairs for ALOX5AP
-
OriGene qPCR primer pairs and template standards for ALOX5AP
No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ALOX5AP Gene
Orthologs for ALOX5AP Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | ALOX5AP 33 34 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | ALOX5AP 34 |
|
OneToOne | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | ALOX5AP 34 |
|
OneToOne | |
| dog (Canis familiaris) |
Mammalia | ALOX5AP 33 34 |
|
||
| cow (Bos Taurus) |
Mammalia | ALOX5AP 33 34 |
|
||
| mouse (Mus musculus) |
Mammalia | Alox5ap 33 16 34 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Alox5ap 33 |
|
||
| chicken (Gallus gallus) |
Aves | ALOX5AP 33 34 |
|
||
| lizard (Anolis carolinensis) |
Reptilia | ALOX5AP 34 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | alox5ap 33 |
|
||
| Str.11819 33 |
|
||||
| zebrafish (Danio rerio) |
Actinopterygii | alox5ap 33 34 |
|
||
| wufj65d02 33 |
|
- Species where no ortholog for ALOX5AP was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Paralogs for ALOX5AP Gene
Variants for ALOX5AP Gene
| SNP ID | Clin | Chr 13 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs281864911 | not-provided, not provided | 30,758,476(+) | T/C | intron_variant | |
| rs1000006854 | -- | 30,729,860(+) | G/C/T | genic_upstream_transcript_variant, intron_variant | |
| rs1000150654 | -- | 30,746,109(+) | G/A/C | genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant | |
| rs1000151151 | -- | 30,714,637(+) | A/G | genic_upstream_transcript_variant, intron_variant | |
| rs1000152628 | -- | 30,735,107(+) | C/T | genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant |
Residual Variation Intolerance Score:
47.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
0.47;
10.28% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for ALOX5AP Gene
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ALOX5AP Gene
Disorders for ALOX5AP Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| stroke, ischemic |
|
|
| myocardial infarction |
|
|
| macular holes |
|
|
| asthma |
|
|
| cerebrovascular disease |
|
|
Search ALOX5AP in MalaCards
View complete list of genes associated with diseases
UniProtKB/Swiss-Prot
AL5AP_HUMAN- Ischemic stroke (ISCHSTR) [MIM:601367]: A stroke is an acute neurologic event leading to death of neural tissue of the brain and resulting in loss of motor, sensory and/or cognitive function. Ischemic strokes, resulting from vascular occlusion, is considered to be a highly complex disease consisting of a group of heterogeneous disorders with multiple genetic and environmental risk factors. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry.
- Note=Genetic variations in ALOX5AP may be associated with susceptibility to myocardial infarction. Involvement in myocardial infarction is however unclear: according to some authors (PubMed:14770184), a 4-SNP haplotype in ALOX5AP confers risk of myocardial infarction, while according to other (PubMed:17304054) ALOX5AP is not implicated in this condition. {ECO:0000269 PubMed:14770184, ECO:0000269 PubMed:17304054}.
Additional Disease Information for ALOX5AP
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No data available for Genatlas for ALOX5AP Gene
Publications for ALOX5AP Gene
- The gene encoding 5-lipoxygenase activating protein confers risk of myocardial infarction and stroke. (PMID: 14770184) Helgadottir A … Stefansson K (Nature genetics 2004) 3 4 22 44 58
- Gene characterization and promoter analysis of the human 5-lipoxygenase-activating protein (FLAP). (PMID: 1673682) Kennedy BP … Dixon RA (The Journal of biological chemistry 1991) 2 3 4 22 58
- The role of LTA4H and ALOX5AP genes in the risk for asthma in Latinos. (PMID: 20067482) Via M … Genetics of Asthma in Latino Americans (GALA) Study (Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology 2010) 3 22 44 58
- Association of a genetic variant in the ALOX5AP with higher risk of ischemic stroke: a case-control, meta-analysis and functional study. (PMID: 20357438) Domingues-Montanari S … Montaner J (Cerebrovascular diseases (Basel, Switzerland) 2010) 3 22 44 58
- [Association of the ALOX5AP gene SG13S114 A/T polymorphism with atherosclerosis]. (PMID: 20376802) He YL … Chen QY (Zhonghua yi xue yi chuan xue za zhi = Zhonghua yixue yichuanxue zazhi = Chinese journal of medical genetics 2010) 3 22 44 58
Products for ALOX5AP Gene
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- Custom Antibody ServicesOriGene Antibodies for ALOX5AP
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- Invitrogen Antibodies for ALOX5AP
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- ApexBio compounds for ALOX5AP
- Cyagen custom Knockout/knockin (KOKI) mouse models for ALOX5AP
- VectorBuilder custom plasmid, inducible vectors for ALOX5AP
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- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- antibodies-online: Search results for 63 available ALOX5AP Antibodies ranked by validation data
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- antibodies-online: Search results for 8 available ALOX5AP Elisa Kits ranked by validation data
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- antibodies-online: Search results for 5 available ALOX5AP Proteins ranked by validation data
- Compare Top ALOX5AP Proteins
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- GeneTex ALOX5AP antibody for ALOX5AP
- Search GeneTex for Proteins for ALOX5AP
- ViGene Biosciences adenoviral particle packaged cDNA for ALOX5AP gene
- ViGene Biosciences lentiviral particle packaged cDNA for ALOX5AP gene
- ViGene Biosciences ready-to-package AAV shRNAs for ALOX5AP gene
- Search ViGene Biosciences for ALOX5AP
- Browse Santa Cruz Biotechnology (SCBT) Antibodies
- Search Santa Cruz Biotechnology (SCBT) for ALOX5AP siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for ALOX5AP
- Horizon Cell Lines for ALOX5AP
- genomics-online: cdna clones - Search results for 120 available ALOX5AP gene related products
- Overview of 120 available ALOX5AP gene related products
- orf clones - Search results for 120 available ALOX5AP gene related products
- Overview of 120 available ALOX5AP gene related products
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- Overview of 120 available ALOX5AP gene related products
- genomics-online: primer clones - Search results for 120 available ALOX5AP gene related products
- Overview of 120 available ALOX5AP gene related products
- genomics-online: shRNA clones - Search results for 120 available ALOX5AP gene related products
- Overview of 120 available ALOX5AP gene related products
Sources for ALOX5AP Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
- (106) GTEx
- (107) ProteomicsDB
- (108) SCBT
- (109) DGIdb
- (110) ClinicalTrials
- (111) FDA Approved Drugs
- (112) RVIS
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- (114) diseasecard
- (115) NIH Rare Diseases
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- (120) Genetics Home Reference
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- (125) NCBI Bookshelf
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- (133) ENCODE
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- (135) Horizon
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- (138) Cyagen
- (139) VectorBuilder
- (140) SNPedia
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- (143) CIViC
- (144) ProteoGenix
- (145) dbSUPER
- (146) TISSUES
- (147) Gene ORGANizer
- (148) abm
- (149) CrownBio
- (150) Human Protein Atlas
- (151) GWAS Catalog
- (152) Monarch Initiative
- (153) DataMed
- (154) HumanCyc
- (155) genomics-online
- (156) UCNEbase
- (157) EPDnew