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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ALOX5AP Gene

protein-coding   GIFtS: 67
GCID: GC13P031309

Arachidonate 5-Lipoxygenase-Activating Protein
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Aliases
for ALOX5AP gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section
Aliases
Arachidonate 5-Lipoxygenase-Activating Protein1 2
MK-886-Binding Protein1 2 3
FLAP2 3 5
Five-Lipoxygenase Activating Protein1

External Ids:    HGNC: 4361   Entrez Gene: 2412   Ensembl: ENSG000001329657   OMIM: 6037005   UniProtKB: P202923   

Export aliases for ALOX5AP gene to outside databases

Previous GC identifers: GC13P029289 GC13P025289 GC13P030239 GC13P029108 GC13P029109 GC13P030207 GC13P012127


Summaries
for ALOX5AP gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for ALOX5AP Gene:
This gene encodes a protein which, with 5-lipoxygenase, is required for leukotriene synthesis. Leukotrienes are
arachidonic acid metabolites which have been implicated in various types of inflammatory responses, including
asthma, arthritis and psoriasis. This protein localizes to the plasma membrane. Inhibitors of its function impede
translocation of 5-lipoxygenase from the cytoplasm to the cell membrane and inhibit 5-lipoxygenase activation.
Alternatively spliced transcript variants encoding different isoforms have been identified for this gene.
(provided by RefSeq, Feb 2011)

GeneCards Summary for ALOX5AP Gene: 
ALOX5AP (arachidonate 5-lipoxygenase-activating protein) is a protein-coding gene. Diseases associated with ALOX5AP include asthma, and psoriasis, and among its related super-pathways are Arachidonic acid metabolism and Metabolic pathways. GO annotations related to this gene include enzyme binding and protein homodimerization activity. An important paralog of this gene is LTC4S.

UniProtKB/Swiss-Prot: AL5AP_HUMAN, P20292
Function: Required for leukotriene biosynthesis by ALOX5 (5-lipoxygenase). Anchors ALOX5 to the membrane. Binds
arachidonic acid, and could play an essential role in the transfer of arachidonic acid to ALOX5. Binds to MK-886,
a compound that blocks the biosynthesis of leukotrienes

summary for ALOX5AP Gene:
Lipoxygenases (LOXs) are a family of non-heme iron dioxygenases that are involved in the production and
metabolism of fatty acid hydroperoxidases. There are six lipoxygenase isozymes; 5-LOX, 12R-LOX, 12S-LOX,
15-LOX-1 and 15-LOX-2, which catalyze the regio-selective addition of oxygen into arachidonic acid, and
epidermal LOX (E-LOX) which metabolizes 12R-hydroperoxyeicosatetraenoic acid (12R-HPETE) to a specific
epoxyalcohol compound. Different isozymes have different physiological roles; 5-, 12R-, 12S- and 15-LOX-1
have proliferative, antiapoptotic and angiogenic functions whilst 15-LOX-2 has roles in differentiation,
growth arrest and the induction of apoptosis. E-LOX, the most divergent member of this family, is involved
in terminal differentiation of keratinocytes and has a major role in skin barrier function. Perturbations in
lipoxygenase enzymes have been implicated in various human diseases including bronchial asthma,
atherosclerosis, osteoporosis and some cancers.

Gene Wiki entry for ALOX5AP (5-lipoxygenase-activating protein) Gene


Genomic Views
for ALOX5AP gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000013.10  NC_018924.2  NT_024524.14  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ALOX5AP gene promoter:
         GR   STAT1   AML1a   AP-1   GATA-3   POU3F2 (N-Oct-5a)   POU3F2 (N-Oct-5b)   Nkx2-5   POU3F2   GR-alpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: ALOX5AP promoter sequence
   Search SABiosciences Chromatin IP Primers for ALOX5AP

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ALOX5AP


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 13q12   Ensembl cytogenetic band:  13q12.3   HGNC cytogenetic band: 13q12

ALOX5AP Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ALOX5AP gene location

GeneLoc information about chromosome 13         GeneLoc Exon Structure

GeneLoc location for GC13P031309:  view genomic region     (about GC identifiers)

Start:
 31,287,615 bp from pter      End:
 31,338,565 bp from pter
Size:
 50,951 bases      Orientation:
 plus strand

Proteins
for ALOX5AP gene

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section
UniProtKB/Swiss-Prot: AL5AP_HUMAN, P20292 (See protein sequence)
Recommended Name: Arachidonate 5-lipoxygenase-activating protein  
Size: 161 amino acids; 18157 Da
Subunit: Homotrimer. Interacts with LTC4S and ALOX5
Subcellular location: Nucleus membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass
membrane protein
2 PDB 3D structures from and Proteopedia for ALOX5AP:
2Q7M (3D)        2Q7R (3D)    
Secondary accessions: Q5VV04

Explore the universe of human proteins at neXtProt for ALOX5AP: NX_P20292

Explore proteomics data for ALOX5AP at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P20292

    • ALOX5AP Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    ALOX5AP Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_001191335.1  NP_001620.2  

    ENSEMBL proteins: 
     ENSP00000369858  
    Reactome Protein details: P20292
    Human Recombinant Protein Products for ALOX5AP: 
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    Novus Biologicals ALOX5AP Protein
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    Sino Biological Recombinant Protein for ALOX5AP
    Sino Biological Cell Lysate for ALOX5AP 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for ALOX5AP 

    Gene Ontology (GO): 5/7 cellular component terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus ----
    GO:0005635nuclear envelope TAS--
    GO:0005783endoplasmic reticulum IDA19233132
    GO:0005789endoplasmic reticulum membrane IEA--
    GO:0005829cytosol IEA--

    ALOX5AP for ontologies           About GeneDecksing



    ALOX5AP Antibody Products: 
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    Assay Products for ALOX5AP: 
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    Cloud-Clone Corp. ELISAs for ALOX5AP 
    Cloud-Clone Corp. CLIAs for ALOX5AP

    Protein Domains /
    Families
    for ALOX5AP gene

    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    		 4 InterPro protein domains:
     IPR001446 5_LipOase_AP
     IPR018295 FLAP/GST2/LTC4S_CS
     IPR023352 MAPEG-like_dom
     IPR001129 Membr-assoc_MAPEG

    Graphical View of Domain Structure for InterPro Entry P20292

    ProtoNet protein and cluster: P20292

    2 Blocks protein domains:
    IPB001129 Membrane-associated proteins in eicosanoid and glutathione metabolism (MAPEG)
    IPB001446 Five-lipoxygenase activating protein signature


    UniProtKB/Swiss-Prot: AL5AP_HUMAN, P20292
    Domain: The C-terminal part after residue 140 is mostly unstructured
    Similarity: Belongs to the MAPEG family


    ALOX5AP for domains           About GeneDecksing


    Function
    for ALOX5AP gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section
    Molecular Function:

         UniProtKB/Swiss-Prot Summary: AL5AP_HUMAN, P20292
    Function: Required for leukotriene biosynthesis by ALOX5 (5-lipoxygenase). Anchors ALOX5 to the membrane. Binds
    arachidonic acid, and could play an essential role in the transfer of arachidonic acid to ALOX5. Binds to MK-886,
    a compound that blocks the biosynthesis of leukotrienes

         Genatlas biochemistry entry for ALOX5AP:
    arachidonate 5-lipoxygenase activating protein,expressed in cells of myeloid origin,localized in the nuclear
    envelop,involved in the biosynthesis of leukotrienes (role in inflammation),microsomal,GST superfamily

         Gene Ontology (GO): 5/10 molecular function terms (GO ID links to tree view) (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004364NOT glutathione transferase activity IBA--
    GO:0004464NOT leukotriene-C4 synthase activity IBA--
    GO:0004602NOT glutathione peroxidase activity IBA--
    GO:0005515protein binding IPI19233132
    GO:0008047enzyme activator activity IEA--
         
    ALOX5AP for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for ALOX5AP:
     Synthetic lethal with c-Myc af 

         3 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Alox5ap):
     homeostasis/metabolism  immune system  skeleton 

    ALOX5AP for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for ALOX5AP: Alox5aptm1Jdm Alox5aptm1Bhk

       inGenious Targeting Laboratory - Custom generated mouse model solutions for ALOX5AP 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for ALOX5AP

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for ALOX5AP 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for ALOX5AP 

    miRNA
    Products:            		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ALOX5AP
    1 QIAGEN miScript miRNA Assays for microRNA that regulate ALOX5AP:
    hsa-miR-570
    SwitchGear 3'UTR luciferase reporter plasmid: ALOX5AP 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for ALOX5AP
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    Gene Editing
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    Clone
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    Cell Line
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    Search LifeMap BioReagents cell lines for ALOX5AP
    In Situ Assay
    Products:       
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    Pathways & Interactions
    for ALOX5AP gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for ALOX5AP About   (see all 7)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Arachidonic acid metabolism
    		Arachidonic acid metabolism0.44
    		Synthesis of Leukotrienes (LT) and Eoxins (EX)0.41
    2Metabolism
    		Metabolism0.40
    		Metabolism of lipids and lipoproteins0.34
    3Synthesis of 15-eicosatetraenoic acid derivatives
    		Synthesis of 5-eicosatetraenoic acids0.33
    		Synthesis of Lipoxins (LX)0.33
    4aspirin triggered resolvin E biosynthesis
    		Leukotriene modifiers pathway, Pharmacodynamics0.30
    5Selenium Pathway
    		Selenium Pathway

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    3 BioSystems Pathways for ALOX5AP
        Eicosanoid Synthesis
    IL-5 Signaling Pathway
    Selenium Pathway


    5/6        Reactome Pathways for ALOX5AP (see all 6)
        Synthesis of Lipoxins (LX)
    Metabolism
    Synthesis of Leukotrienes (LT) and Eoxins (EX)
    Arachidonic acid metabolism
    Synthesis of 5-eicosatetraenoic acids

    1 PharmGKB Pathway for ALOX5AP
        Leukotriene modifiers pathway, Pharmacodynamics


    ALOX5AP for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for ALOX5AP

    STRING Interaction Network Preview (showing 5 interactants - click image to see 6)

    5/6 Interacting proteins for ALOX5AP (P202923 ENSP000003698584) via UniProtKB, MINT, STRING, and/or I2D (see all 6)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ALOX5P099173, ENSP000003635124I2D: score=3 STRING: ENSP00000363512
    LTC4SQ168733, ENSP000002925964I2D: score=1 STRING: ENSP00000292596
    LTA4HENSP000002287404STRING: ENSP00000228740
    ABCC1ENSP000003823424STRING: ENSP00000382342
    MAPKAPK2ENSP000003560704STRING: ENSP00000356070
    About this table

    Gene Ontology (GO): 5/10 biological process terms (GO ID links to tree view) (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0002540leukotriene production involved in inflammatory response IEA--
    GO:0002675positive regulation of acute inflammatory response IEA--
    GO:0006691leukotriene metabolic process TAS--
    GO:0019369arachidonic acid metabolic process TAS--
    GO:0019370leukotriene biosynthetic process IDA2300173

    ALOX5AP for ontologies           About GeneDecksing



    Drugs & Compounds
    for ALOX5AP gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    ALOX5AP for compounds           About GeneDecksing

    EMD Millipore small molecules for ALOX5AP:
    Small Molecule - inhibitor
    Enzo Life Sciences drugs & compounds for ALOX5AP

    Compounds for ALOX5AP available from Tocris Bioscience    About this table
    CompoundAction CAS #
    BAY-X 1005Orally active 5-lipoxygenase activating protein (FLAP) inhibitor[128253-31-6]
    BW-B 70C5-Lipoxygenase inhibitor[134470-38-5]
    ZileutonOrally active 5-LOX inhibitor[111406-87-2]
    MK 886Inhibitor of 5-lipoxygenase-activating protein (FLAP)[118414-82-7]
    Baicalein5- and 12-Lipoxygenase inhibitor[491-67-8]

    10/31 Novoseek inferred chemical compound relationships for ALOX5AP gene (see all 31)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    5-hpete 87.7 5 8344271 (2), 9630716 (1), 7473582 (1)
    mk 886 86.6 17 10333477 (4), 11389700 (2), 16817014 (1), 19346216 (1) (see all 10)
    ltc4 86.1 63 8703034 (5), 9278457 (4), 9431445 (3), 8052639 (3) (see all 17)
    arachidonic acid 82.5 108 8049076 (4), 8440384 (3), 8344271 (3), 10036194 (2) (see all 47)
    leukotriene b4 80.9 28 15593193 (3), 9150468 (2), 9609743 (2), 17156456 (2) (see all 19)
    zileuton 78.5 5 9609743 (2), 12649539 (1), 18037915 (1), 9113110 (1)
    5-hydroxyeicosatetraenoic acid 78.3 6 8358023 (3), 16185917 (1), 11090070 (1)
    montelukast 60.8 4 18591367 (1), 19058495 (1), 18037915 (1), 17460547 (1)
    pranlukast 58.7 1 19058495 (1)
    zafirlukast 55.3 1 19058495 (1)

    Search CenterWatch for drugs/clinical trials and news about ALOX5AP / AL5AP

    Transcripts
    for ALOX5AP gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
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    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for ALOX5AP gene (2 alternative transcripts): 
    NM_001204406.1  NM_001629.3  

    Unigene Cluster for ALOX5AP:

    Arachidonate 5-lipoxygenase-activating protein
    Hs.507658  [show with all ESTs]
    Unigene Representative Sequence: BU198818
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000380490(uc010tdr.2 uc001utf.2) ENST00000479597

    miRNA
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    Additional mRNA sequence: 

    AK314143.1 BC018538.1 

    13 DOTS entries:

    DT.455424  DT.92432935  DT.120780307  DT.92432937  DT.100036052  DT.92045150  DT.95234653  DT.95339664 
    DT.100036055  DT.100036056  DT.100036057  DT.100705468  DT.95271540 

    24/167 AceView cDNA sequences (see all 167):

    BM993917 BU743117 BM992846 AV713611 AA353947 H02419 BM773521 CA306377 
    AV716937 AV716674 CA310357 BQ003388 BX350312 BM972232 AA353170 AA309930 
    BQ029402 BU199063 CD369702 BQ187112 CA307605 BQ184220 BM993240 CD370101 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for ALOX5AP    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5 ^ 6a · 6b
    SP1:              -     -           -                           
    SP2:                                -                           
    SP3:              -     -           -     -     -               
    SP4:                    -                                       


    ECgene alternative splicing isoforms for ALOX5AP

    Expression
    for ALOX5AP gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ALOX5AP expression in normal human tissues (normalized intensities)      ALOX5AP embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTTTAAGCTG
    ALOX5AP Expression
    About this image


    ALOX5AP expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/17 selected tissues (see all 17) fully expand
     
     Blood (Hematopoietic System)    fully expand to see all 8 entries
             Plasmacytoid Dendritic cells Peripheral Blood
             Umbilical cord blood-derived hematopoietic stem cells
             Peripheral blood Pan-T Cells   
     
     Liver (Hepatobiliary System)    fully expand to see all 3 entries
             Liver Lobule
             Human Hepatic Stellate Cells (HHSteC)   
     
     Umbilical Cord (Extraembryonic Tissues)    fully expand to see all 2 entries
             Umbilical cord blood-derived hematopoietic stem cells
             Human Umbilical Mesenchymal Stem Cells (HUMSC)   
     
     Endothelium (Cardiovascular System)    fully expand to see all 2 entries
             Peripheral blood-derived early endothelial progenitor cells
             CD31, CD144 positive cells ( Two-step protocol for endothelial differentiation by...
     
     Epithelium (Uncategorized)    fully expand to see all 2 entries
             Human Pulmonary Alveolar Epithelial Cells (HPAEpiC)   

    See ALOX5AP Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ALOX5AP

    SOURCE GeneReport for Unigene cluster: Hs.507658
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    Orthologs
    for ALOX5AP gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of chordates.

    Orthologs for ALOX5AP gene from 5/11 species (see all 11)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Alox5ap1 , 5 arachidonate 5-lipoxygenase activating protein1, 5 85.71(n)1
    91.93(a)1    		   5 (89.18 cM)5
    116901  NM_009663.11  NP_033793.11 
     1492650585 
    chicken
    (Gallus gallus)    		 Aves ALOX5AP1 arachidonate 5-lipoxygenase-activating protein 76.19(n)
    82.61(a)    		   770904  XM_001233118.2  XP_001233119.1 
    lizard
    (Anolis carolinensis)    		 Reptilia ALOX5AP6
    		 Uncharacterized protein
    		 73(a)
    		 1 ↔ 1
    		 3(184489477-184505246)
    tropical clawed frog
    (Xenopus tropicalis)    		 Amphibia Str.118192 Transcribed sequence with moderate similarity to protein more 73.55(n)    CF343935.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii wufj65d022 wufj65d02 73.41(n)   337376  BC053181.1 


    ENSEMBL Gene Tree for ALOX5AP (if available)
    TreeFam Gene Tree for ALOX5AP (if available)

    Paralogs
    for ALOX5AP gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ALOX5AP gene
    LTC4S2  MGST22  
    2 SIMAP similar genes for ALOX5AP using alignment to 1 protein entry:     AL5AP_HUMAN:
    LTC4S    MGST2

    ALOX5AP for paralogs           About GeneDecksing



    Genomic Variants
    for ALOX5AP gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1372 SNPs in ALOX5AP are shown (see all 1372)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 13 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs172454981,2
    		F--12137965(+) AACTTC/TTCCCC 2 -- int14Minor allele frequency- T:0.02NS 184
    rs619473721,2
    		C,F--12234409(+) GAGCAG/ACCTCA 1 -- us2k13Minor allele frequency- A:0.06NA WA 240
    rs1166084191,2
    		C,F--12234432(+) TTCCAT/GTTTGG 1 -- us2k11Minor allele frequency- G:0.03WA 118
    rs1445234721,2
    		--12234597(+) ATTGTC/TTCATA 1 -- us2k10--------
    rs773836721,2
    		C,F--12234621(+) GAAATC/ATGGAA 1 -- us2k11Minor allele frequency- A:0.50NA 2
    rs1423366881,2
    		--12234723(+) CACTCC/TCATCT 1 -- us2k10--------
    rs345363741,2
    		C,F--12234735(+) TGCCTC/TCATTG 1 -- us2k17Minor allele frequency- T:0.22NA WA CSA EA 366
    rs343445661,2
    		C,F--12234737(+) CCTCCA/GTTGTC 1 -- us2k17Minor allele frequency- G:0.22NA WA CSA EA 366
    rs343522401,2
    		C,F--12234746(+) TCACAC/TGGCAT 1 -- us2k18Minor allele frequency- T:0.22WA NA CSA EA 368
    rs1847480281,2
    		--12234795(+) AACATC/TGGTCA 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for ALOX5AP (31287615 - 31338565 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for ALOX5AP:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2747225CNV Deletion23290073
    nsv984CNV Insertion18451855
    nsv832574CNV Gain17160897


    Human Gene Mutation Database (HGMD): ALOX5AP

    Locus Specific Mutation Databases (LSDB): ALOX5AP
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    Disorders / Diseases
    for ALOX5AP gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    		 OMIM gene information: 603700   
    OMIM disorders: 601367  
    UniProtKB/Swiss-Prot: AL5AP_HUMAN, P20292
  • Ischemic stroke (ISCHSTR) [MIM:601367]: A stroke is an acute neurologic event leading to death of neural
    tissue of the brain and resulting in loss of motor, sensory and/or cognitive function. Ischemic strokes,
    resulting from vascular occlusion, is considered to be a highly complex disease consisting of a group of
    heterogeneous disorders with multiple genetic and environmental risk factors. Note=Disease susceptibility is
    associated with variations affecting the gene represented in this entry
  • Note=Genetic variations in ALOX5AP may be associated with susceptibility to myocardial infarction.
    Involvement in myocardial infarction is however unclear: according to some authors (PubMed:14770184), a 4-SNP
    haplotype in ALOX5AP confers risk of myocardial infarction, while according to other (PubMed:17304054) ALOX5AP is
    not implicated in this condition

    • 20/47 diseases for ALOX5AP (see all 47):    About MalaCards
    asthma    psoriasis    atherosclerosis    familial hypercholesterolemia
    cerebrovascular accident    proteinuria    primary pulmonary hypertension    acquired immunodeficiency syndrome
    cerebral infarction    cerebral palsy    arthritis    angioedema
    cerebrovascular disease    urticaria    hypercholesterolemia    sickle cell disease
    mantle cell lymphoma    allergic rhinitis    glomerulonephritis    rhinitis

    1 disease from the University of Copenhagen DISEASES database for ALOX5AP:
    Cerebrovascular accident

    ALOX5AP for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    10/23 Novoseek inferred disease relationships for ALOX5AP gene (see all 23)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    thrombotic stroke 62.7 1 16939001 (1)
    asthma 57.7 41 20067482 (6), 15784112 (5), 18547289 (4), 12911785 (4) (see all 14)
    stroke 37.8 59 19126581 (4), 15731479 (4), 15640973 (3), 16939001 (3) (see all 20)
    myocardial infarction 37.1 33 14770184 (3), 16778124 (3), 16282974 (2), 17176247 (2) (see all 14)
    inflammation 37 8 19239910 (2), 16261187 (1), 19759251 (1), 18775537 (1) (see all 7)
    cardiovascular diseases 31.5 6 15640973 (2), 16261187 (1), 19239910 (1), 16778124 (1)
    atherosclerosis 27.6 5 20376802 (2), 18258817 (1), 15581413 (1), 16278051 (1)
    asthma allergic 27.6 1 8994519 (1)
    coronary artery disease 16.7 6 19596330 (3), 17505527 (2), 15861005 (1), 18318662 (1)
    nephropathy iga 10.1 1 8468935 (1)

    Genetic Association Database (GAD): ALOX5AP
    Human Genome Epidemiology (HuGE) Navigator: ALOX5AP (69 documents)

    Export disorders for ALOX5AP gene to outside databases

    Publications
    for ALOX5AP gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ALOX5AP gene, integrated from 9 sources (see all 259):
    (articles sorted by number of sources associating them with ALOX5AP)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Gene characterization and promoter analysis of the human 5- lipoxygenase-activating protein (FLAP). (PubMed id 1673682)1, 2, 3, 9 Kennedy B.P.... Dixon R.A.F. (1991)
    2. The gene encoding 5-lipoxygenase activating protein confers risk of myocardial infarction and stroke. (PubMed id 14770184)1, 2, 4, 9 Helgadottir A.... Stefansson K. (2004)
    3. No association of polymorphisms in the gene encoding 5-lipoxygenase-activating protein and myocardial infarction in a large central European population. (PubMed id 17304054)1, 2, 4 Koch W....Kastrati A. (2007)
    4. Genetic variation in the arachidonate 5-lipoxygenase-activating protein (ALOX5AP) is associated with myocardial infarction in the German population. (PubMed id 18318662)1, 4, 9 Linsel-Nitschke P....Erdmann J. (2008)
    5. Association of a genetic variant in the ALOX5AP with higher risk of ischemic stroke: a case-control, meta-analysis and functional st udy. (PubMed id 20357438)1, 4, 9 Domingues-Montanari S....Montaner J. (2010)
    6. The role of LTA4H and ALOX5AP genes in the risk for a sthma in Latinos. (PubMed id 20067482)1, 4, 9 Via M....GonzA!lez Burchard E. (2010)
    7. Arachidonate 5-lipoxygenase-activating protein (ALOX5AP) gene and coronary heart disease risk in familial hypercholesterolemia. (PubMed id 18775537)1, 4, 9 van der Net J.B....Sijbrands E.J. (2008)
    8. Variants of the arachidonate 5-lipoxygenase-activating protein (ALOX5AP) gene and risk of stroke: a HuGE gene-disease association review and meta-analysis. (PubMed id 19126581)1, 4, 9 Zintzaras E....Sakellaridis N. (2009)
    9. Polymorphisms in the 5-lipoxygenase activating protein (ALOX5AP) gene are not associated with asthma in an Australian population. (PubMed id 15784112)1, 4, 9 Kedda M.A....Thompson P.J. (2005)
    10. 5-lipoxygenase and 5-lipoxygenase-activating protein are localized in the nuclear envelope of activated human leukocytes. (PubMed id 8245774)1, 2, 9 Woods J.W....Singer I.I. (1993)

    External Searches for ALOX5AP gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing ALOX5AP gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 241 HGNC: 436 AceView: ALOX5AP Ensembl:ENSG00000132965 euGenes: HUgn241
    ECgene: ALOX5AP H-InvDB: ALOX5AP

    Other Databases showing ALOX5AP gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing ALOX5AP gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ALOX5AP Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for ALOX5AP Genetics and Cytogenetics in Oncology and Haematology
    SeattleSNPshttp://pga.gs.washington.edu/data/alox5ap/

    Intellectual Property
    for ALOX5AP gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for ALOX5AP gene:
    Search GeneIP for patents involving ALOX5AP

    GeneCards and IP:
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    About This Section

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