ALOX5AP Gene
protein-coding GIFtS : 67 GCID: GC13 P031309
Arachidonate 5-Lipoxygenase-Activating Protein
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Aliasesfor ALOX5AP gene
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc ,
7 Ensembl ,
8 DME ,
9 miRBase ,
10 fRNAdb ,
12 H-InvDB ,
13 NCBI ,
14 NONCODE ,
and/or 15 RNAdb )About This Section Aliases Arachidonate 5-Lipoxygenase-Activating Protein 1 2 MK-886-Binding Protein1 2 3 FLAP2 3 5 Five-Lipoxygenase Activating Protein1
Export aliases for ALOX5AP gene to outside databases Previous GC identifers: GC13P029289 GC13P025289 GC13P030239 GC13P029108 GC13P029109 GC13P030207 GC13P012127
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Summariesfor ALOX5AP gene (According to Entrez Gene ,
Tocris Bioscience ,
Wikipedia's
Gene Wiki ,
PharmGKB ,UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
About This Section Entrez Gene summary for ALOX5AP Gene: This gene encodes a protein which, with 5-lipoxygenase, is required for leukotriene synthesis. Leukotrienes are arachidonic acid metabolites which have been implicated in various types of inflammatory responses, including asthma, arthritis and psoriasis. This protein localizes to the plasma membrane. Inhibitors of its function impede translocation of 5-lipoxygenase from the cytoplasm to the cell membrane and inhibit 5-lipoxygenase activation. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene. (provided by RefSeq, Feb 2011) GeneCards Summary for ALOX5AP Gene: ALOX5AP (arachidonate 5-lipoxygenase-activating protein) is a protein-coding gene. Diseases associated with ALOX5AP include asthma psoriasis related super-pathways are Arachidonic acid metabolism and Metabolic pathways . GO annotations related to this gene include enzyme binding and protein homodimerization activity . An important paralog of this gene is LTC4S . UniProtKB/Swiss-Prot: AL5AP_HUMAN, P20292 Function : Required for leukotriene biosynthesis by ALOX5 (5-lipoxygenase). Anchors ALOX5 to the membrane. Bindsarachidonic acid, and could play an essential role in the transfer of arachidonic acid to ALOX5. Binds to MK-886, a compound that blocks the biosynthesis of leukotrienes summary
for ALOX5AP Gene: Lipoxygenases (LOXs) are a family of non-heme iron dioxygenases that are involved in the production andmetabolism of fatty acid hydroperoxidases. There are six lipoxygenase isozymes; 5-LOX, 12R-LOX, 12S-LOX,15-LOX-1 and 15-LOX-2, which catalyze the regio-selective addition of oxygen into arachidonic acid, andepidermal LOX (E-LOX) which metabolizes 12R-hydroperoxyeicosatetraenoic acid (12R-HPETE) to a specificepoxyalcohol compound. Different isozymes have different physiological roles; 5-, 12R-, 12S- and 15-LOX-1have proliferative, antiapoptotic and angiogenic functions whilst 15-LOX-2 has roles in differentiation,growth arrest and the induction of apoptosis. E-LOX, the most divergent member of this family, is involvedin terminal differentiation of keratinocytes and has a major role in skin barrier function. Perturbations inlipoxygenase enzymes have been implicated in various human diseases including bronchial asthma,atherosclerosis, osteoporosis and some cancers. Gene Wiki entry for ALOX5AP (5-lipoxygenase-activating protein) Gene
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Genomic Viewsfor ALOX5AP gene
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 37) ,miRBase ,UCSC (hg19) and
Ensembl (release 73) ,
Regulatory elements and Epigenetics data according to
QIAGEN ,
SABiosciences , and/or
SwitchGear Genomics )About This Section RefSeq DNA sequence: NC_000013.10 NC_018924.2 NT_024524.14 Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the ALOX5AP gene promoter:GR STAT1 AML1a AP-1 GATA-3 POU3F2 (N-Oct-5a) POU3F2 (N-Oct-5b) Nkx2-5 POU3F2 GR-alpha Other transcription factors Search SABiosciences Chromatin IP Primers for ALOX5AP Epigenetics: QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ALOX5AP
Genomic Location: Genomic View : UCSC Golden Path with GeneCards custom track Entrez Gene cytogenetic band: 13q12 Ensembl cytogenetic band: 13q12.3 HGNC cytogenetic band: 13q12 ALOX5AP Gene in genomic location: bands according to Ensembl, locations according to
Entrez Gene Ensembl GeneLoc information about chromosome 13 GeneLoc Exon Structure
GeneLoc location for GC13P031309: view genomic region
(about GC identifiers )
Start: 31,287,615 bp from pter End:
31,338,565 bp from pter
Size: 50,951 bases Orientation:
plus strand
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Proteinsfor ALOX5AP gene
(According to
UniProtKB ,
HORDE ,
neXtProt ,
Ensembl ,
and/or Reactome ,
Modification sites according to PhosphoSitePlus ,
Specific Peptides from DME ,
Protein expression images according to data from SPIRE 1 MOPED ,
2 PaxDb , and 3 MAXQB
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from
EMD Millipore ,
R&D Systems ,
GenScript ,
Enzo Life Sciences ,
OriGene ,
Novus Biologicals ,
Sino Biological ,
ProSpec , and/or
Cloud-Clone Corp. ,
EMD Millipore ,
R&D Systems ,
OriGene ,
GenScript ,
Cell Signaling Technology ,
Enzo Life Sciences , and/or
Cloud-Clone Corp. ,
Ontologies according to Gene
Ontology Consortium 01 Oct 2013 and
Entrez Gene ,
Antibodies by
EMD Millipore ,
R&D Systems ,
GenScript ,
Cell Signaling Technology ,
OriGene ,
Novus Biologicals ,
Thermo Fisher Scientific ,
LSBio ,
Abcam , and/or
Cloud-Clone Corp. )
About This Section UniProtKB/Swiss-Prot: AL5AP_HUMAN, P20292 See
protein sequence )Recommended Name: Size : 161 amino acids; 18157 DaSubunit : Homotrimer. Interacts with LTC4S and ALOX5Subcellular location : Nucleus membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-passmembrane protein
2 PDB 3D structures from :2Q7M (3D) 2Q7R (3D) Secondary accessions : Q5VV04Explore the universe of human proteins at neXtProt for ALOX5AP: NX_P20292 Explore proteomics data for ALOX5AP at MOPED Post-translational modifications:
View modification sites using PhosphoSitePlus View neXtProt modification sites for NX_P20292 ALOX5AP Protein expression data from MOPED1 2 3 : About this image REFSEQ proteins (2 alternative transcripts): NP_001191335.1 NP_001620.2 ENSEMBL proteins: ENSP00000369858 Reactome Protein details: P20292 Human Recombinant Protein Products for ALOX5AP: Gene Ontology (GO): 5/7 cellular component terms (GO ID links to tree view) (see all 7 ): About this table
About GeneDecksing ALOX5AP Antibody Products: Assay Products for ALOX5AP:
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Protein
Domains /for ALOX5AP gene (According to HGNC , IUPHAR , InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
About This Section 4 InterPro protein domains :
Graphical View of Domain Structure for InterPro Entry P20292 ProtoNet protein and cluster: P20292
2 Blocks protein domains : IPB001129 IPB001446 UniProtKB/Swiss-Prot: AL5AP_HUMAN, P20292 Domain : The C-terminal part after residue 140 is mostly unstructuredSimilarity : Belongs to the MAPEG familyAbout GeneDecksing
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Functionfor ALOX5AP gene
(According to 1 UniProtKB ,
Genatlas ,
LifeMap Discovery™ ,
IUBMB , and/or
2 DME ,
Human phenotypes from GenomeRNAi ,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory ,
SABiosciences ,
miRNA Gene Targets from miRTarBase ,
shRNA from
OriGene ,
Sirion Biotech ,
RNAi from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
microRNA from QIAGEN ,
Gene Editing from DNA2.0 ,
Sirion Biotech ,
Clones from EMD Millipore ,
OriGene ,
SwitchGear Genomics ,
GenScript ,
Sino Biological ,
DNA2.0 ,
and Vector BioLabs ,
Cell Lines from GenScript ,
LifeMap BioReagents ,
Sirion Biotech ,
In Situ Hybridization Assays from Advanced Cell Diagnostics ,
Ontologies according to Gene Ontology Consortium 01 Oct 2013 via
Entrez Gene .)
About This Section Molecular Function: UniProtKB/Swiss-Prot Summary: AL5AP_HUMAN, P20292 Function : Required for leukotriene biosynthesis by ALOX5 (5-lipoxygenase). Anchors ALOX5 to the membrane. Bindsarachidonic acid, and could play an essential role in the transfer of arachidonic acid to ALOX5. Binds to MK-886, a compound that blocks the biosynthesis of leukotrienes
Genatlas biochemistry entry for ALOX5AP arachidonate 5-lipoxygenase activating protein,expressed in cells of myeloid origin,localized in the nuclear envelop,involved in the biosynthesis of leukotrienes (role in inflammation),microsomal,GST superfamily Gene Ontology (GO): 5/10 molecular function terms (GO ID links to tree view) (see all 10 ): About this table
About GeneDecksing Phenotypes: 1 GenomeRNAi human phenotype for ALOX5AP :3 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Alox5ap) :About GeneDecksing Animal Models: Alox5ap tm1Jdm Alox5ap tm1Bhk In Situ AssayAdvanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ALOX5AP
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Pathways & Interactionsfor ALOX5AP gene
(Pathways according to
EMD Millipore ,
R&D Systems ,
Cell Signaling Technology ,
KEGG ,
PharmGKB ,
BioSystems ,
Sino Biological ,
Reactome ,
Tocris Bioscience ,
GeneGo (Thomson Reuters) ,
QIAGEN ,
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Interaction Networks according to
SABiosciences ,
and/or STRING ,
Interactions according to 1 UniProtKB ,
2 MINT ,
3 I2D , and/or
4 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Oct 2013 via
Entrez Gene) .
About This Section SuperPaths for ALOX5AP About (see all 7 ) See pathways by source SuperPath Contained pathways About 1 Arachidonic acid metabolism 2 Metabolism 3 Synthesis of 15-eicosatetraenoic acid derivatives 4 aspirin triggered resolvin E biosynthesis 5 Selenium Pathway
Pathways by source See SuperPaths Show all pathways 3 5/6 (see all 6 )1 ALOX5AP About GeneDecksing Interactions: SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for ALOX5AP STRING Interaction
Network Preview (showing 5 interactants - click image to see 6)5/6 Interacting proteins for ALOX5AP (P20292 3 ENSP00000369858 4 via UniProtKB, MINT, STRING , and/or I2D (see all 6 )About this table Gene Ontology (GO): 5/10 biological process terms (GO ID links to tree view) (see all 10 ): About this table
GO ID Qualified GO term Evidence PubMed IDs GO:0002540 leukotriene production involved in inflammatory response
IEA -- GO:0002675 positive regulation of acute inflammatory response
IEA -- GO:0006691 leukotriene metabolic process
TAS -- GO:0019369 arachidonic acid metabolic process
TAS -- GO:0019370 leukotriene biosynthetic process
IDA 2300173
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Drugs & Compoundsfor ALOX5AP gene (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
EMD Millipore , Tocris Bioscience
HMDB ,
BitterDB , and/or
Novoseek , and Drugs according to
DrugBank ,
IUPHAR ,
Enzo Life Sciences , and/or
PharmGKB , with drugs/clinical trials/news
search links to CenterWatch )
About This Section About GeneDecksing Enzo Life Sciences drugs & compounds for ALOX5AP
Compounds for ALOX5AP available from Tocris Bioscience About this table Compound Action
CAS
# BAY-X 1005 Orally active 5-lipoxygenase activating protein (FLAP) inhibitor [128253-31-6] BW-B 70C 5-Lipoxygenase inhibitor [134470-38-5] Zileuton Orally active 5-LOX inhibitor [111406-87-2] MK 886 Inhibitor of 5-lipoxygenase-activating protein (FLAP) [118414-82-7] Baicalein 5- and 12-Lipoxygenase inhibitor [491-67-8]
10/31 Novoseek inferred chemical compound relationships for ALOX5AP gene (see all 31 ) About this table
Compound
-log (P-Val)
Hits
PubMed IDs for Articles with Shared Sentences (# sentences)
5-hpete
87.7
5
8344271 (2), 9630716 (1), 7473582 (1)
mk 886
86.6
17
10333477 (4), 11389700 (2), 16817014 (1), 19346216 (1) (see
all 10 )
ltc4
86.1
63
8703034 (5), 9278457 (4), 9431445 (3), 8052639 (3) (see
all 17 )
arachidonic acid
82.5
108
8049076 (4), 8440384 (3), 8344271 (3), 10036194 (2) (see
all 47 )
leukotriene b4
80.9
28
15593193 (3), 9150468 (2), 9609743 (2), 17156456 (2) (see
all 19 )
zileuton
78.5
5
9609743 (2), 12649539 (1), 18037915 (1), 9113110 (1)
5-hydroxyeicosatetraenoic acid
78.3
6
8358023 (3), 16185917 (1), 11090070 (1)
montelukast
60.8
4
18591367 (1), 19058495 (1), 18037915 (1), 17460547 (1)
pranlukast
58.7
1
19058495 (1)
zafirlukast
55.3
1
19058495 (1)
ALOX5AP / AL5AP
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Transcriptsfor ALOX5AP gene (Secondary structures according to
fRNAdb ,Unigene
(Build 236 Homo sapiens; Apr 25 2013) or GenBank , Entrez Gene ,
DOTS (version 10), and/or
AceView ,
transcript ids from Ensembl
with links to UCSC , KenesGroup ,
exon structure from GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,EMD Millipore ,
OriGene ,
QIAGEN ,
shRNA from
OriGene ,
Sirion Biotech ,
microRNA from QIAGEN ,
OriGene ,
SwitchGear Genomics ,
GenScript ,
DNA2.0 ,
Vector BioLabs ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN
)About This Section REFSEQ mRNAs for ALOX5AP gene (2 alternative transcripts): NM_001204406.1 NM_001629.3 Unigene Cluster for ALOX5AP:
Arachidonate 5-lipoxygenase-activating protein Hs.507658 [show with all ESTs ] Unigene Representative Sequence: BU198818 2 Ensembl transcripts including schematic representations, and UCSC links where relevant : ENST00000380490 (uc010tdr.2 uc001utf.2 ) ENST00000479597 Primer ALOX5AP human mouse SABiosciences RT2 qPCR Primer Assay in human mouse rat QIAGEN QuantiTect SYBR Green Assays in human mouse rat QIAGEN QuantiFast Probe-based Assays in human mouse rat
Additional mRNA sequence: AK314143.1 BC018538.1
13 DOTS entries : DT.455424 DT.92432935
DT.120780307 DT.92432937 DT.100036052 DT.92045150 DT.95234653 DT.95339664 DT.100036055 DT.100036056 DT.100036057 DT.100705468 DT.95271540 24/167 AceView cDNA sequences (see all 167 ):
BM993917 BU743117 BM992846 AV713611 AA353947 H02419 BM773521 CA306377 AV716937 AV716674 CA310357 BQ003388 BX350312 BM972232 AA353170 AA309930 BQ029402 BU199063 CD369702 BQ187112 CA307605 BQ184220 BM993240 CD370101 GeneLoc Exon Structure 4 Alternative Splicing Database (ASD) splice patterns (SP) for ALOX5AP About this scheme ExUns: 1a · 1b ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5 ^ 6a · 6b SP1 : - - - SP2 : - SP3 : - - - - - SP4 : -
ECgene alternative splicing isoforms for ALOX5AP
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Expression for ALOX5AP gene
(RNA expression data according to
H-InvDB ,
NONCODE ,
miRBase , and
RNAdb ,
Expression images according to data from
BioGPS ,
Illumina Human BodyMap , and
CGAP
SAGE ,
Sets of similar genes according to GeneDecks ,
in vivo and in vitro expression data from LifeMap Discovery™ ,
plus additional links to
Genevestigator , and/or
SOURCE , and/or
BioGPS , and/or
UniProtKB ,SABiosciences ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN ,
In Situ Hybridization Assays from Advanced Cell Diagnostics )
About This Section ALOX5AP expression in normal human tissues
(normalized intensities) ALOX5AP embryonic expression: see See probesets specificity/sensitivity at GeneAnnot About this image BioGPS 2/3 CGAP TAG: TTTTAAGCTGAbout this image
ALOX5AP expression in embryonic tissues and stem cells About this table LifeMap ,
the Embryonic Development and Stem Cells Database 5/5 selected tissues (see all 5 ) fully expand See ALOX5AP Protein Expression from SPIRE MOPED and PaxDB Genevestigator expression for ALOX5AP SOURCE GeneReport for Unigene cluster: Hs.507658 SABiosciences Custom PCR Arrays for ALOX5AP Primer ALOX5AP human mouse SABiosciences RT2 qPCR Primer Assay in human mouse rat QIAGEN QuantiTect SYBR Green Assays in human mouse rat QIAGEN QuantiFast Probe-based Assays in human mouse rat In Situ Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ALOX5AP
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Orthologsfor ALOX5AP gene
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
,
5 MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase ,
and/or
6 Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam )
About This Section Orthologs for ALOX5AP gene from 5/11 species (see all 11 ) About this table
Organism
Taxonomic
Gene
Description
Human
Orthology
Details
mouse Mammalia Alox5ap1 5
arachidonate 5-lipoxygenase activating protein1, 5
85.71(n) 1 91.93(a) 1
5 (89.18 cM) 5 11690 1 NM_009663.1 1 NP_033793.1 1 149265058 5
chicken Aves ALOX5AP1
arachidonate 5-lipoxygenase-activating protein
76.19(n) 82.61(a)
770904 XM_001233118.2 XP_001233119.1
lizard Reptilia ALOX5AP6
Uncharacterized protein
73(a)
1 ↔ 1
3(184489477-184505246)
tropical clawed frog Amphibia Str.118192
Transcribed sequence with moderate similarity to protein more
73.55(n)
CF343935.1
zebrafish Actinopterygii wufj65d022
wufj65d02
73.41(n)
337376 BC053181.1
ENSEMBL Gene Tree for ALOX5AP (if available)TreeFam Gene Tree for ALOX5AP (if available)
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Paralogsfor ALOX5AP gene (Paralogs according to
1 HomoloGene ,2 Ensembl , and 3 SIMAP , Pseudogenes according to 4 Pseudogene.org Build 68)About This Section Paralogs for ALOX5AP gene LTC4S 2 MGST2 2 2 SIMAP similar genes for ALOX5AP using alignment to 1 protein entry: AL5AP_HUMAN :LTC4S MGST2 About GeneDecksing
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Genomic Variantsfor ALOX5AP gene (SNPs/Variants according to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE ,
4 UniProtKB , and
DNA2.0 ,
Linkage Disequilibrium by HapMap ,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants , Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB) , Blood group antigen gene mutations by BGMUT ,
Resequencing Primers from QIAGEN ,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences )
About This Section Genomic Data Transcription Related Data Allele Frequencies SNP ID Valid Clinical Chr 13 pos Sequence # AA Type More # Allele Pop Total More
HapMap Linkage Disequilibrium report for ALOX5AP (31287615 - 31338565 bp)
Structural Variations Database of Genomic Variants (DGV) 3 variations for ALOX5AP : About this table Human Gene Mutation Database (HGMD) : ALOX5AP Locus Specific Mutation Databases (LSDB): ALOX5AP SABiosciences Cancer Mutation PCR Assays
QIAGEN SeqTarget long-range PCR primers in human mouse rat
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Disorders
/ Diseasesfor ALOX5AP gene
(in which this Gene is Involved, According to MalaCards ,
OMIM, UniProtKB ,
the University of Copenhagen DISEASES
database , Conferences by KenesGroup ,
Novoseek , Genatlas , GeneTests ,
GAD ,
HuGE Navigator ,
and/or TGDB .)
About This Section About GeneDecksing OMIM gene information: 603700 OMIM disorders : 601367 UniProtKB/Swiss-Prot: AL5AP_HUMAN, P20292 Ischemic stroke (ISCHSTR) [MIM:601367]: A stroke is an acute neurologic event leading to death of neural tissue of the brain and resulting in loss of motor, sensory and/or cognitive function. Ischemic strokes, resulting from vascular occlusion, is considered to be a highly complex disease consisting of a group of heterogeneous disorders with multiple genetic and environmental risk factors. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry Note=Genetic variations in ALOX5AP may be associated with susceptibility to myocardial infarction. Involvement in myocardial infarction is however unclear: according to some authors (PubMed:14770184), a 4-SNP haplotype in ALOX5AP confers risk of myocardial infarction, while according to other (PubMed:17304054) ALOX5AP is not implicated in this condition 20/47 (see all 47 ): About MalaCards asthma psoriasis atherosclerosis familial hypercholesterolemia cerebrovascular accident proteinuria primary pulmonary hypertension acquired immunodeficiency syndrome cerebral infarction cerebral palsy arthritis angioedema cerebrovascular disease urticaria hypercholesterolemia sickle cell disease mantle cell lymphoma allergic rhinitis glomerulonephritis rhinitis 1 disease from the University of Copenhagen DISEASES database for ALOX5AP :Cerebrovascular accident Congresses - knowledge worth sharing: Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015 10/23 Novoseek inferred disease relationships for ALOX5AP gene (see all 23 ) About this table
Disease
-log (P-Val)
Hits
PubMed IDs for Articles with Shared Sentences (# sentences)
thrombotic stroke
62.7
1
16939001 (1)
asthma
57.7
41
20067482 (6), 15784112 (5), 18547289 (4), 12911785 (4) (see
all 14 )
stroke
37.8
59
19126581 (4), 15731479 (4), 15640973 (3), 16939001 (3) (see
all 20 )
myocardial infarction
37.1
33
14770184 (3), 16778124 (3), 16282974 (2), 17176247 (2) (see
all 14 )
inflammation
37
8
19239910 (2), 16261187 (1), 19759251 (1), 18775537 (1) (see
all 7 )
cardiovascular diseases
31.5
6
15640973 (2), 16261187 (1), 19239910 (1), 16778124 (1)
atherosclerosis
27.6
5
20376802 (2), 18258817 (1), 15581413 (1), 16278051 (1)
asthma allergic
27.6
1
8994519 (1)
coronary artery disease
16.7
6
19596330 (3), 17505527 (2), 15861005 (1), 18318662 (1)
nephropathy iga
10.1
1
8468935 (1)
Genetic Association Database (GAD): ALOX5AP Human Genome Epidemiology (HuGE) Navigator: ALOX5AP (69 documents) Export disorders for ALOX5AP gene to outside databases
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Publicationsfor ALOX5AP gene (in
PubMed .
Associations of this gene to articles via
1 Entrez Gene ,
2 UniProtKB/Swiss-Prot ,
3 HGNC ,
4 GAD ,
5 PharmGKB ,
6 HMDB ,
7 DrugBank ,
8 UniProtKB/TrEMBL ,
9 Novoseek , and/or
10 fRNAdb )
About This Section PubMed articles for ALOX5AP gene, integrated from 9 sources (see all 259 ):(articles sorted by number of sources associating them with ALOX5AP) Utopia : connect your pdf to the dynamic
Gene characterization and promoter analysis of the human 5- lipoxygenase-activating protein (FLAP). (PubMed id 1673682) 1 , 2 , 3, 9(1991) The gene encoding 5-lipoxygenase activating protein confers risk of myocardial infarction and stroke. (PubMed id 14770184) 1 , 2 , 4, 9(2004) No association of polymorphisms in the gene encoding 5-lipoxygenase-activating protein and myocardial infarction in a large central European population. (PubMed id 17304054) 1 , 2 , 4(2007) Genetic variation in the arachidonate 5-lipoxygenase-activating protein (ALOX5AP) is associated with myocardial infarction in the German population. (PubMed id 18318662) 1 , 4, 9(2008) Association of a genetic variant in the ALOX5AP with higher risk of ischemic stroke: a case-control, meta-analysis and functional st udy. (PubMed id 20357438) 1 , 4, 9(2010) The role of LTA4H and ALOX5AP genes in the risk for a sthma in Latinos. (PubMed id 20067482) 1 , 4, 9(2010) Arachidonate 5-lipoxygenase-activating protein (ALOX5AP) gene and coronary heart disease risk in familial hypercholesterolemia. (PubMed id 18775537) 1 , 4, 9(2008) Variants of the arachidonate 5-lipoxygenase-activating protein (ALOX5AP) gene and risk of stroke: a HuGE gene-disease association review and meta-analysis. (PubMed id 19126581) 1 , 4, 9(2009) Polymorphisms in the 5-lipoxygenase activating protein (ALOX5AP) gene are not associated with asthma in an Australian population. (PubMed id 15784112) 1 , 4, 9(2005) 5-lipoxygenase and 5-lipoxygenase-activating protein are localized in the nuclear envelope of activated human leukocytes. (PubMed id 8245774) 1 , 2 , 9(1993)
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External Searches for ALOX5AP gene
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Genome Databases showing ALOX5AP gene
(According to
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Ensembl ,
miRBase ,
ECgene ,
Kegg ,
and/or
H-InvDB )
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Specialized Databases showing ALOX5AP gene (According to PharmGKB ,
ATLAS , HORDE , IMGT , LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
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About This Section Patent Information for ALOX5AP gene: ALOX5AP GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Productsfor ALOX5AP gene (Antibodies, recombinant proteins, and assays from EMD Millipore , R&D Systems , OriGene , QIAGEN , GenScript , Cell Signaling Technology , SABiosciences , Novus Biologicals , Sino Biological , Enzo Life Sciences , Abcam , ProSpec , Cloud-Clone Corp. , Thermo Fisher Scientific , LSBio , Gene Editing from DNA2.0 and Sirion Biotech , Clones from EMD Millipore , OriGene , GenScript , Sino Biological , DNA2.0 , SwitchGear Genomics , Vector BioLabs , Cell lines from GenScript , LifeMap BioReagents , and Sirion Biotech , PCR Arrays from SABiosciences , Drugs and/or compounds from EMD Millipore , Tocris Bioscience , and/or
Enzo Life Sciences , In Situ Hybridization Assays from Advanced Cell Diagnostics , Animal models from inGenious Targeting Laboratory )About This Section
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat ALOX5AP QIAGEN SeqTarget long-range PCR primers in human mouse rat QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ALOX5AP QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human mouse rat QIAGEN QuantiFast Probe-based Assays in human mouse rat QIAGEN QuantiTect SYBR Green Assays in human mouse rat
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ALOX5AP
ThermoFisher Antibodies for ALOX5AP
Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat ALOX5AP
LSBio Antibodies in human mouse rat
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summary
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and Proteopedia 
for ALOX5AP:
