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Aliases for ALOX5AP Gene

Aliases for ALOX5AP Gene

  • Arachidonate 5-Lipoxygenase-Activating Protein 2 3
  • MK-886-Binding Protein 2 3 4
  • FLAP 3 4 6
  • Five-Lipoxygenase Activating Protein 2

External Ids for ALOX5AP Gene

Previous GeneCards Identifiers for ALOX5AP Gene

  • GC13P029289
  • GC13P025289
  • GC13P030239
  • GC13P029108
  • GC13P029109
  • GC13P030207
  • GC13P031309
  • GC13P012127

Summaries for ALOX5AP Gene

Entrez Gene Summary for ALOX5AP Gene

  • This gene encodes a protein which, with 5-lipoxygenase, is required for leukotriene synthesis. Leukotrienes are arachidonic acid metabolites which have been implicated in various types of inflammatory responses, including asthma, arthritis and psoriasis. This protein localizes to the plasma membrane. Inhibitors of its function impede translocation of 5-lipoxygenase from the cytoplasm to the cell membrane and inhibit 5-lipoxygenase activation. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Feb 2011]

GeneCards Summary for ALOX5AP Gene

ALOX5AP (Arachidonate 5-Lipoxygenase-Activating Protein) is a Protein Coding gene. Diseases associated with ALOX5AP include stroke, ischemic and psoriasis. Among its related pathways are Metabolism and Metabolism. GO annotations related to this gene include protein homodimerization activity and enzyme binding. An important paralog of this gene is MGST2.

UniProtKB/Swiss-Prot for ALOX5AP Gene

  • Required for leukotriene biosynthesis by ALOX5 (5-lipoxygenase). Anchors ALOX5 to the membrane. Binds arachidonic acid, and could play an essential role in the transfer of arachidonic acid to ALOX5. Binds to MK-886, a compound that blocks the biosynthesis of leukotrienes.

Tocris Summary for ALOX5AP Gene

  • Lipoxygenases (LOXs) are a family of non-heme iron dioxygenases that are involved in the production and metabolism of fatty acid hydroperoxidases. There are six lipoxygenase isozymes; 5-LOX, 12R-LOX, 12S-LOX, 15-LOX-1 and 15-LOX-2, which catalyze the regio-selective addition of oxygen into arachidonic acid, and epidermal LOX (E-LOX) which metabolizes 12R-hydroperoxyeicosatetraenoic acid (12R-HPETE) to a specific epoxyalcohol compound. Different isozymes have different physiological roles; 5-, 12R-, 12S- and 15-LOX-1 have proliferative, antiapoptotic and angiogenic functions whilst 15-LOX-2 has roles in differentiation, growth arrest and the induction of apoptosis. E-LOX, the most divergent member of this family, is involved in terminal differentiation of keratinocytes and has a major role in skin barrier function. Perturbations in lipoxygenase enzymes have been implicated in various human diseases including bronchial asthma, atherosclerosis, osteoporosis and some cancers.

Gene Wiki entry for ALOX5AP Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ALOX5AP Gene

Genomics for ALOX5AP Gene

Regulatory Elements for ALOX5AP Gene

Genomic Location for ALOX5AP Gene

Start:
30,713,478 bp from pter
End:
30,764,428 bp from pter
Size:
50,951 bases
Orientation:
Plus strand

Genomic View for ALOX5AP Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ALOX5AP Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ALOX5AP Gene

Proteins for ALOX5AP Gene

  • Protein details for ALOX5AP Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P20292-AL5AP_HUMAN
    Recommended name:
    Arachidonate 5-lipoxygenase-activating protein
    Protein Accession:
    P20292
    Secondary Accessions:
    • Q5VV04

    Protein attributes for ALOX5AP Gene

    Size:
    161 amino acids
    Molecular mass:
    18157 Da
    Quaternary structure:
    • Homotrimer. Interacts with LTC4S and ALOX5.

    Three dimensional structures from OCA and Proteopedia for ALOX5AP Gene

neXtProt entry for ALOX5AP Gene

Proteomics data for ALOX5AP Gene at MOPED

Post-translational modifications for ALOX5AP Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ALOX5AP Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for ALOX5AP Gene

Domains for ALOX5AP Gene

Suggested Antigen Peptide Sequences for ALOX5AP Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P20292

UniProtKB/Swiss-Prot:

AL5AP_HUMAN :
  • P20292
Domain:
  • The C-terminal part after residue 140 is mostly unstructured.
Family:
  • Belongs to the MAPEG family.
genes like me logo Genes that share domains with ALOX5AP: view

No data available for Gene Families for ALOX5AP Gene

Function for ALOX5AP Gene

Molecular function for ALOX5AP Gene

GENATLAS Biochemistry: arachidonate 5-lipoxygenase activating protein,expressed in cells of myeloid origin,localized in the nuclear envelop,involved in the biosynthesis of leukotrienes (role in inflammation),microsomal,GST superfamily
UniProtKB/Swiss-Prot Function: Required for leukotriene biosynthesis by ALOX5 (5-lipoxygenase). Anchors ALOX5 to the membrane. Binds arachidonic acid, and could play an essential role in the transfer of arachidonic acid to ALOX5. Binds to MK-886, a compound that blocks the biosynthesis of leukotrienes.

Gene Ontology (GO) - Molecular Function for ALOX5AP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004051 arachidonate 5-lipoxygenase activity --
GO:0004364 NOT glutathione transferase activity IBA --
GO:0004464 NOT leukotriene-C4 synthase activity IBA --
GO:0004602 NOT glutathione peroxidase activity IBA --
GO:0005515 protein binding IPI 19233132
genes like me logo Genes that share ontologies with ALOX5AP: view
genes like me logo Genes that share phenotypes with ALOX5AP: view

Animal Models for ALOX5AP Gene

MGI Knock Outs for ALOX5AP:

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ALOX5AP

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targeting and HOMER Transcription for ALOX5AP Gene

Localization for ALOX5AP Gene

Subcellular locations from UniProtKB/Swiss-Prot for ALOX5AP Gene

Nucleus membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ALOX5AP Gene COMPARTMENTS Subcellular localization image for ALOX5AP gene
Compartment Confidence
endoplasmic reticulum 5
nucleus 5
cytosol 2
lysosome 2
plasma membrane 2

Gene Ontology (GO) - Cellular Components for ALOX5AP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus --
GO:0005635 nuclear envelope TAS --
GO:0005783 endoplasmic reticulum IDA 19233132
GO:0005789 endoplasmic reticulum membrane IEA --
GO:0005829 cytosol --
genes like me logo Genes that share ontologies with ALOX5AP: view

Pathways for ALOX5AP Gene

genes like me logo Genes that share pathways with ALOX5AP: view

Gene Ontology (GO) - Biological Process for ALOX5AP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002540 leukotriene production involved in inflammatory response --
GO:0002675 positive regulation of acute inflammatory response --
GO:0006691 leukotriene metabolic process TAS --
GO:0019369 arachidonic acid metabolic process TAS --
GO:0019370 leukotriene biosynthetic process IDA 2300173
genes like me logo Genes that share ontologies with ALOX5AP: view

Compounds for ALOX5AP Gene

(5) Tocris Compounds for ALOX5AP Gene

Compound Action Cas Number
2-TEDC 5-, 12-, 15-Lipoxygenase inhibitor [132465-10-2]
BW-B 70C 5-Lipoxygenase inhibitor [134470-38-5]
MK 886 Inhibitor of 5-lipoxygenase-activating protein (FLAP) [118414-82-7]
PD 146176 Selective 15-lipoxygenase inhibitor [4079-26-9]
Zileuton Orally active 5-LOX inhibitor [111406-87-2]

(31) Novoseek inferred chemical compound relationships for ALOX5AP Gene

Compound -log(P) Hits PubMed IDs
5-hpete 87.7 4
mk 886 86.6 14
ltc4 86.1 33
arachidonic acid 82.5 61
leukotriene b4 80.9 25
genes like me logo Genes that share compounds with ALOX5AP: view

Transcripts for ALOX5AP Gene

mRNA/cDNA for ALOX5AP Gene

Unigene Clusters for ALOX5AP Gene

Arachidonate 5-lipoxygenase-activating protein:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ALOX5AP

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ALOX5AP Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5 ^ 6a · 6b
SP1: - - -
SP2: -
SP3: - - - - -
SP4: -

Relevant External Links for ALOX5AP Gene

GeneLoc Exon Structure for
ALOX5AP
ECgene alternative splicing isoforms for
ALOX5AP

Expression for ALOX5AP Gene

mRNA expression in normal human tissues for ALOX5AP Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ALOX5AP Gene

This gene is overexpressed in Whole Blood (40.3).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for ALOX5AP Gene

SOURCE GeneReport for Unigene cluster for ALOX5AP Gene Hs.507658

genes like me logo Genes that share expressions with ALOX5AP: view

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for ALOX5AP Gene

Orthologs for ALOX5AP Gene

This gene was present in the common ancestor of chordates.

Orthologs for ALOX5AP Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ALOX5AP 35
  • 98.62 (n)
  • 99.08 (a)
ALOX5AP 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ALOX5AP 35
  • 86.13 (n)
  • 90.68 (a)
ALOX5AP 36
  • 91 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ALOX5AP 35
  • 86.89 (n)
  • 91.26 (a)
ALOX5AP 36
  • 78 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Alox5ap 35
  • 85.71 (n)
  • 91.93 (a)
Alox5ap 16
Alox5ap 36
  • 92 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ALOX5AP 36
  • 91 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ALOX5AP 36
  • 90 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Alox5ap 35
  • 85.09 (n)
  • 91.93 (a)
chicken
(Gallus gallus)
Aves ALOX5AP 35
  • 76.19 (n)
  • 82.61 (a)
ALOX5AP 36
  • 82 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ALOX5AP 36
  • 72 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia alox5ap 35
  • 72.05 (n)
  • 79.5 (a)
Str.11819 35
zebrafish
(Danio rerio)
Actinopterygii alox5ap 35
  • 62.82 (n)
  • 58.97 (a)
alox5ap 36
  • 57 (a)
OneToOne
wufj65d02 35
Species with no ortholog for ALOX5AP:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ALOX5AP Gene

ENSEMBL:
Gene Tree for ALOX5AP (if available)
TreeFam:
Gene Tree for ALOX5AP (if available)

Paralogs for ALOX5AP Gene

Paralogs for ALOX5AP Gene

Selected SIMAP similar genes for ALOX5AP Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with ALOX5AP: view

Variants for ALOX5AP Gene

Sequence variations from dbSNP and Humsavar for ALOX5AP Gene

SNP ID Clin Chr 13 pos Sequence Context AA Info Type MAF
rs1132340 -- 30,764,325(+) TTCCC(A/G)TGCAT utr-variant-3-prime
rs3803277 -- 30,744,171(+) CCTAA(A/C)CCTGA intron-variant
rs3803278 -- 30,744,264(+) CCAAG(C/T)TTCTG intron-variant
rs3809376 -- 30,734,585(+) CCCAC(A/C)CAGCA intron-variant, upstream-variant-2KB
rs3885907 -- 30,740,318(+) CCCTC(A/C)GTTTC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ALOX5AP Gene

Variant ID Type Subtype PubMed ID
nsv832574 CNV Gain 17160897
esv2747225 CNV Deletion 23290073
nsv984 CNV Insertion 18451855

Relevant External Links for ALOX5AP Gene

HapMap Linkage Disequilibrium report
ALOX5AP
Human Gene Mutation Database (HGMD)
ALOX5AP
Locus Specific Mutation Databases (LSDB)
ALOX5AP

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ALOX5AP Gene

Disorders for ALOX5AP Gene

MalaCards: The human disease database

MalaCards: The human disease database. (5) Diseases for ALOX5AP Gene including...

Search for ALOX5AP Gene in MalaCards »

(1) OMIM Diseases for ALOX5AP Gene (603700)

UniProtKB/Swiss-Prot

AL5AP_HUMAN
  • Ischemic stroke (ISCHSTR) [MIM:601367]: A stroke is an acute neurologic event leading to death of neural tissue of the brain and resulting in loss of motor, sensory and/or cognitive function. Ischemic strokes, resulting from vascular occlusion, is considered to be a highly complex disease consisting of a group of heterogeneous disorders with multiple genetic and environmental risk factors. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry.
  • Note=Genetic variations in ALOX5AP may be associated with susceptibility to myocardial infarction. Involvement in myocardial infarction is however unclear: according to some authors (PubMed:14770184), a 4-SNP haplotype in ALOX5AP confers risk of myocardial infarction, while according to other (PubMed:17304054) ALOX5AP is not implicated in this condition. {ECO:0000269 PubMed:14770184, ECO:0000269 PubMed:17304054}.

(1) University of Copenhagen DISEASES for ALOX5AP Gene

(23) Novoseek inferred disease relationships for ALOX5AP Gene

Disease -log(P) Hits PubMed IDs
thrombotic stroke 62.7 1
asthma 57.7 30
stroke 37.8 40
myocardial infarction 37.1 22
inflammation 37 8

Relevant External Links for ALOX5AP

Genetic Association Database (GAD)
ALOX5AP
Human Genome Epidemiology (HuGE) Navigator
ALOX5AP
genes like me logo Genes that share disorders with ALOX5AP: view

Publications for ALOX5AP Gene

  1. Gene characterization and promoter analysis of the human 5- lipoxygenase-activating protein (FLAP). (PMID: 1673682) Kennedy B.P. … Dixon R.A.F. (J. Biol. Chem. 1991) 2 3 4 23
  2. The gene encoding 5-lipoxygenase activating protein confers risk of myocardial infarction and stroke. (PMID: 14770184) Helgadottir A. … Stefansson K. (Nat. Genet. 2004) 3 4 23 48
  3. Promoter polymorphism in the 5-lipoxygenase (ALOX5) and 5-lipoxygenase-activating protein (ALOX5AP) genes and asthma susceptibility in a Caucasian population. (PMID: 12911785) Sayers I. … Holgate S.T. (Clin. Exp. Allergy 2003) 3 23 48
  4. Association between the gene encoding 5-lipoxygenase-activating protein and stroke replicated in a Scottish population. (PMID: 15640973) Helgadottir A. … MacLeod M.J. (Am. J. Hum. Genet. 2005) 3 23 48
  5. ALOX5AP gene and the PDE4D gene in a central European population of stroke patients. (PMID: 15731479) LA/hmussaar E. … Dichgans M. (Stroke 2005) 3 23 48

Products for ALOX5AP Gene

Sources for ALOX5AP Gene

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