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ALOX5 Gene

protein-coding GIFtS: 69

GC10P045189

arachidonate 5-lipoxygenase
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
5-LO ^², ³
5-LOX ^¹, ²
5-lipoxygenase ^³
5LPG ^²
EC 1.13.11.34 ^³
LOG5 ^², ³
MGC163204 ^²
OTTHUMP00000019502 ^²

Descriptions
arachidonate 5-lipoxygenase ^²
arachidonic acid 5-lipoxygenase ^²
leukotriene A4 synthase ^²

External Ids
HGNC: 435¹
Entrez Gene: 240²
UniProtKB: P09917³
Ensembl: ENSG00000012779⁷

Search outside databases for aliases for ALOX5 gene

Previous GC identifers: GC10P045171 GC10P045338 GC10P045644 GC10P045153

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for ALOX5:

This gene encodes a member of the lipoxygenase gene family and plays a dual role in the synthesis

of leukotrienes from arachidonic acid. The encoded protein, which is expressed specifically in

bone marrow-derived cells, catalyzes the conversion of arachidonic acid to

5(S)-hydroperoxy-6-trans-8,11,14-cis-eicosatetraenoic acid, and further to the allylic epoxide

5(S)-trans-7,9-trans-11,14-cis-eicosatetrenoic acid (leukotriene A4). Leukotrienes are important

mediators of a number of inflammatory and allergic conditions. Mutations in the promoter region of

this gene lead to a diminished response to antileukotriene drugs used in the treatment of asthma

and may also be associated with atherosclerosis and several cancers. Alternatively spliced

transcript variants have been observed, but their full-length nature has not been determined.

[provided by RefSeq]

UniProtKB/Swiss-Prot: LOX5_HUMAN, P09917

Function: Catalyzes the first step in leukotriene biosynthesis, and thereby plays a role in

inflammatory processes

Gene Wiki entry for ALOX5 (Arachidonate_5-lipoxygenase)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the ALOX5 gene

Entrez Gene cytogenetic band: 10q11.2 Ensembl cytogenetic band: 10q11.21 HGNC cytogenetic band: 10q11.2

ALOX5 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 10 GeneLoc Exon Structure

GeneLoc location for GC10P045189: (about GC identifiers)

Start:	45,189,635 bp from pter
End:	45,261,571 bp from pter
Size:	71,937 bases
Orientation:	plus strand

RefSeq DNA sequence:

NC_000010.9 NT_033985.6

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: LOX5_HUMAN, P09917 (See protein sequence)

Recommended Name: Arachidonate 5-lipoxygenase

Size: 674 amino acids; 77983 Da

Cofactor: Binds 1 iron ion per subunit (By similarity)

Cofactor: Binds 2 calcium ions per subunit (By similarity)

Subunit: Interacts with ALOX5AP and LTC4S

Subcellular location: Cytoplasm. Nucleus matrix. Nucleus membrane; Peripheral membrane protein.

Note=Shuttles between cytoplasm and nucleus. Found exclusively in the nucleus, when phosphorylated

on Ser-272. Calcium binding promotes translocation from the cytosol and the nuclear matrix to the

nuclear envelope and membrane association

PDB structures from and Proteopedia :

2ABV (3D)

Secondary accessions: Q5JQ14

Post-translational modifications:

Serine phosphorylation by MAPKAPK2 is stimulated by arachidonic acid. Phosphorylation on Ser-523 by

PKA has an inhibitory effect. Phosphorylation on Ser-272 prevents export from the nucleus¹

View phosphorylation sites using PhosphoSite²

REFSEQ proteins: NP_000689.1

ENSEMBL proteins:

ENSP00000363512

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Enzo Life Sciences proteins for ALOX5
	Recombinant Proteins from Abcam (5 Lipoxygenase)
	Human Recombinant Proteins from Abnova (ALOX5)

OriGene Purified Recombinant Human Protein: ALOX5

3 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	IEA	--
GO:0005737	cytoplasm	IEA	--
GO:0016020	membrane	IEA	--

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Antibodies for ALOX5:

	Invitrogen Antibodies for ALOX5
	Millipore Mono- and Polyclonal Antibodies for the study of ALOX5
	Sigma-Aldrich Antibodies for ALOX5
	R&D Systems Antibodies for ALOX5 (5-Lipoxygenase)
	Cell Signaling Technology (CST) Antibodies for ALOX5 (5-Lipoxygenase)
	Antibodies from Abcam (5 Lipoxygenase), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (ALOX5)
	Novus Biologicals Antibodies for ALOX5

Assays for ALOX5:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry P09917

ProtoNet protein and cluster: P09917

3 Blocks protein families:

IPB000907 Lipoxygenase

IPB001024 Lipoxygenase

IPB001885 Mammalian lipoxygenase signature

UniProtKB/Swiss-Prot: LOX5_HUMAN, P09917

Similarity: Belongs to the lipoxygenase family

Similarity: Contains 1 lipoxygenase domain

Similarity: Contains 1 PLAT domain

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (ALOX5)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (ALOX5)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_000698

Applied Biosystems Silencer® siRNAs for ALOX5

Sigma-Aldrich siRNA and siRNA Panels for ALOX5

Sigma-Aldrich shRNA for ALOX5

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Browse Clone Ranger at Invitrogen for clones
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_000698
Myc/DDK tagged cDNA clone in CMV expression vector: NM_000698
untagged cDNA clone in CMV expression vector: NM_000698

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_000698

UniProtKB/Swiss-Prot: LOX5_HUMAN, P09917

Function: Catalyzes the first step in leukotriene biosynthesis, and thereby plays a role in

inflammatory processes

Catalytic activity: Arachidonate + O(2) = leukotriene A(4) + H(2)O

Enzyme Number (IUBMB): EC 1.13.11.34

Genatlas biochemistry entry for ALOX5:

arachidonate-5-lipoxygenase,lipid peroxidating enzyme implicated in the pathogenesis of

inflammatory disorders as well as membrane remodeling,carcinogenesis,atheroma and asthma

formation,involved in leukotriene metabolism

6 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Alox5):

	adipose tissue	hematopoietic system	homeostasis/metabolism	immune system
skeleton

5/6 Gene Ontology (GO) molecular function terms (links to tree view) (see all 6 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004051	arachidonate 5-lipoxygenase activity	TAS	2829172
GO:0005506	iron ion binding	IEA	--
GO:0005509	calcium ion binding	IEA	--
GO:0005515	protein binding	IPI	11297527 11785969
GO:0016165	lipoxygenase activity	IEA	--

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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3 Sigma-Aldrich "Your Favorite Gene" Pathways for ALOX5 (Your Favorite Gene powered by Ingenuity)

Arachidonic Acid Metabolism
Eicosanoid Signaling
Linoleic Acid Metabolism

GeneDecks ALOX5 for the pathways selected above

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UniProtKB/Swiss-Prot: LOX5_HUMAN, P09917

Pathway: Lipid metabolism; leukotriene A4 biosynthesis

Gene Network Central^TM Interacting Genes and Proteins Network for ALOX5

5/65 Interacting proteins for ALOX5 (ENSP00000363512³ P09917¹) via UniProtKB, MINT, and/or STRING (see all 65 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
COTL1	Q14019¹	STRING (score=.968) EBI-79934, EBI-79926
ALOX5AP	ENSP00000369858³	STRING (score=.996)
MAML1	ENSP00000292599³	STRING (score=.995)
LTA4H	ENSP00000228740³	STRING (score=.993)
GRB2	ENSP00000339007³	STRING (score=.978)

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3 Gene Ontology (GO) biological process terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006954	inflammatory response	IEA	--
GO:0019370	leukotriene biosynthetic process	IEA	--
GO:0055114	oxidation reduction	IEA	--

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Enzo Life Sciences drugs & compounds for ALOX5

Sigma-Aldrich Small Molecules for ALOX5:

Inhibitor

Compounds for ALOX5 available from Tocris Bioscience

Compound	Action	CAS number
2-TEDC	5-, 12-, 15-Lipoxygenase inhibitor	[132465-10-2]
BW-B 70C	5-Lipoxygenase inhibitor	[134470-38-5]
STEARDA	Endogenous lipid, active in vivo. Enhances effects of endovanilloids at TRPV1 receptors	[105955-10-0]
Zileuton	Orally active 5-LOX inhibitor	[111406-87-2]
Baicalein	5- and 12-Lipoxygenase inhibitor	[491-67-8]

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10/43 Novoseek chemical compound relationships for ALOX5 gene (see all 43 )

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
leukotriene b4	95.70	436	14530386 (6), 1330161 (5), 1314503 (4), 9142859 (4) (see all 99)
arachidonic acid	94.04	858	16275640 (8), 8049076 (6), 7577949 (4), 11867685 (4) (see all 99)
5-hydroxyeicosatetraenoic acid	92.76	60	8358023 (3), 9789062 (3), 1328141 (1), 8223906 (1) (see all 32)
ltc4	88.65	82	7900879 (3), 10102384 (3), 9296112 (2), 9431445 (2) (see all 49)
licofelone	88.48	45	17704828 (10), 18268076 (2), 11550975 (2), 15498796 (2) (see all 13)
5-hpete	88.44	37	8395245 (4), 7811715 (3), 8164257 (2), 1848236 (2) (see all 18)
sc41661a	86.34	3	8497493 (2), 7747166 (1)
lte4	86.20	27	19336727 (3), 15519606 (2), 2153812 (1), 9596112 (1) (see all 17)
boswellic acids	83.76	23	19374837 (4), 1602379 (3), 9103531 (2), 8510458 (2) (see all 12)
2,3,5-trimethyl-6-(3-pyridylmethyl)-1,4-benzoquinone	81.13	5	1847762 (1), 9062405 (1), 1992126 (1), 1893498 (1) (see all 5)

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3 PharmGKB drug compound relationships for ALOX5 gene

Drug compound	PharmGKB Relations	PubMed IDs for articles supporting these relationships
alox5-pathway modifiers	PD	10369259
xenobiotics	FA GN	11919084
zafirlukast	PD GN	12107604

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (ALOX5)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (ALOX5)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_000698

Sigma-Aldrich siRNA and siRNA Panels for ALOX5

Sigma-Aldrich shRNA for ALOX5

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_000698

REFSEQ mRNAs for ALOX5 gene:

NM_000698.2

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_000698

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_000698
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_000698
                                 untagged cDNA clone in CMV expression vector: NM_000698

Additional cDNA sequence:

AK225603.1 AK315223.1 BC034464.1 BC040450.1 BC130332.1 BC132677.1 BC143985.1 BC143986.1

J03571.1 J03600.1

8 DOTS entries:

DT.449694 DT.92427412 DT.95193567 DT.97806426 DT.100771760 DT.210270 DT.86839247 DT.95142328

24/177 AceView cDNA sequences (see all 177 ):

BI837266 CA390028 AI799008 AI798007 AA315865 AI698814 CA439600 BX346381

BQ787144 AI380545 BM726803 BI822076 AA587201 AI075284 BX377162 AA767516

BE676451 BE710304 AA926891 BC040450 BQ786870 AA505143 BC034464 BX386145

highest scoring ESTs for ALOX5:

J03600 AA315865 AA521143 AA552112 AA593920 AA613560 AA707722 AA748796 AA766333 AA767202

Unigene Cluster for ALOX5:

Arachidonate 5-lipoxygenase

Hs.89499 [show with all ESTs]

Unigene Representative Sequence: NM_000698

GeneLoc Exon Structure

1 Ensembl transcript including schematic representation:

ENST00000374391

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
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ALOX5 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for ALOX5

¹ / ² / ³

7 probe-sets matching ALOX5 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
307_at²^{, 3}	U95-A	1	1.00	1.00	1.00	1.00	J03600	1.00	1.00	1.00	1
204446_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_000698	0.60	1.00	0.82	1
204445_s_at²^{, 3}	U133-A	2	1.00	0.55	--	--	AI361850	0.60	1.00	0.82	1
214366_s_at²^{, 3}	U133-A	2	1.00	0.50	--	--	AA995910	0.40	1.00	0.76	1
204446_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
204445_s_at²	U133Plus2	2	1.00	0.55	--	--	--	--	--	--	--
214366_s_at²	U133Plus2	2	1.00	0.50	--	--	--	--	--	--	--

GeneDecks ALOX5 for binary patterns associated with the probe-sets selected above

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Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: GGATGATTAT

SOURCE GeneReport for Unigene cluster: Hs.89499
Expression variation in blood from EXPOLDB for ALOX5

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for ALOX5 gene from 5/7 species (see all 7 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	ALOX5¹	--	arachidonate 5-lipoxygenase	88.78(n) 91.94(a)	477753 XM_534950.2 XP_534950.2
chimpanzee (Pan troglodytes)	ALOX5¹	--	arachidonate 5-lipoxygenase	96.23(n) 95.68(a)	450428 XM_507763.2 XP_507763.2
cow (Bos taurus)	ALOX5¹	--	arachidonate 5-lipoxygenase	90.11(n) 91.99(a)	404074 XM_613515.3 XP_613515.3
rat (Rattus norvegicus)	Alox5¹	--	arachidonate 5-lipoxygenase	86.29(n) 92.94(a)	25290 NM_012822.1 NP_036954.1
mouse (Mus musculus)	Alox5^{1, 5}	6 (53.20 cM)⁵	arachidonate 5-lipoxygenase^{1, 5}	87.88(n)¹ 93.47(a)¹	11689¹ NM_009662.2¹ NP_033792.1¹ AA388919⁵ AI850497⁵ (see all 20)

About this table Species with no ortholog for ALOX5

ENSEMBL Gene Tree for ALOX5

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for ALOX5 gene

ALOX12B² ALOXE3²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/467 NCBI SNPs in ALOX5 are shown (see all 467 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 173)

AB	SNP ID	Valid	Chr 10 pos	Sequence	Recs	AA Chg	Type	More	Recs	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--			--
	rs6593482^1,2	A,C,F,H	45188455(+)	`tatccG/Tattag`	1	--	ng5¹		8	EU EA WA	836
	rs7913948^1,2	A,C,F,H	45188895(+)	`CGCGCG/AAAACC`	1	--	ng5¹ tfbs³		8	EU EA WA	836
--	rs12762303^1,2	A,C,F	45189177(+)	`GCCCTT/CCTGAT`	1	--	ng5¹		1	NA	48
	rs6413416^1,2	C,F,H	45187981(+)	`ctataG/Acactg`	1	--	ng5¹		13	MN CSAM EA EU WA	1238
	rs2228065^1,2	C,F,H	45240512(+)	`TGCCCG/AAGAAG`	1	K/E	mis¹ ese³		16	MN EA CSAM EU WA NA	2766
--	rs4986832^1,2	C,F	45188034(+)	`gatcaG/Atggac`	1	--	ng5¹		5	MN CSAM EA	400
	rs13134^1,2	C,H	45261411(+)	`AATCAC/TGACCA`	1	--	ut3¹ ese³		6	MN EU EA WA NA	682
--	rs41314980^1,2	C,F	45261505(+)	`AGGTAC/ACCAAT`	1	--	ut3¹		1	NA	48
--	rs4986834^1,2	F	45188023(+)	`tgtacA/Gttaca`	1	--	ng5¹		5	MN CSAM EA	400
--	rs41365544^1,2	F	45261417(+)	`GACCAC/ATGATA`	1	--	ut3¹		1	NA	48

About this table

HapMap Linkage Disequilibrium images for ALOX5 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 152390

10/91 Novoseek disease relationships for ALOX5 gene (see all 91 )

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
asthma	72.77	165	8473681 (4), 8129222 (4), 16364163 (4), 8598621 (4) (see all 93)
inflammation	68.28	106	16250846 (3), 1309754 (2), 12733982 (2), 17305572 (2) (see all 85)
leukemia basophilic	61.30	16	8071328 (2), 12005204 (1), 8140120 (1), 19243697 (1) (see all 12)
ear edema	60.90	4	1665293 (2), 7916384 (1), 9599246 (1)
asthma exercise-induced	60.30	5	8630575 (2), 16027142 (1), 10984370 (1), 17481554 (1)
allergic rhinitis	49.22	7	9809497 (1), 12607939 (1), 1701029 (1), 9444606 (1) (see all 6)
anaphylaxis	45.41	9	8081074 (3), 1949224 (1), 8480540 (1), 9532969 (1) (see all 6)
atherosclerosis	45.33	45	17481551 (2), 14702425 (2), 18842779 (2), 17825794 (2) (see all 28)
edema	44.59	17	7541689 (2), 1478686 (2), 9444606 (1), 8129222 (1) (see all 12)
asthma allergic	44.17	7	8994519 (1), 9444606 (1), 1851340 (1), 17481554 (1) (see all 6)

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3 PharmGKB disease relationships for ALOX5 gene

Disease	PharmGKB Relations	PubMed IDs for articles supporting these relationships
Arteriosclerosis	CO PD GN	14702425
Asthma	PD FA GN	10369259 11919084 12107604
Leukemia, Lymphocytic, Acute, L1	FA GN	12086872 12730115

About this table

Human Gene Mutation Database: ALOX5
Genetic Association Database: ALOX5
Human Genome Epidemiology Navigator: ALOX5 (42 documents)

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
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10/1044 PubMed articles for ALOX5 gene (see all 1044 ):

Arachidonate 5-lipoxygenase promoter genotype, dietary arachidonic acid, and atherosclerosis. (PubMed id 14702425)^{1, 3, 6, 7} Dwyer J.H....Mehrabian M. (2004)
Arachidonate lipoxygenase (ALOX) and cyclooxygenase (COX) polymorphisms and colon cancer risk. (PubMed id 15308583)^{3, 4, 6} Goodman J.E.... Harris C.C. (2004)
5-Lipoxygenase polymorphism and in-vivo response to leukotriene receptor antagonists. (PubMed id 12107604)^{3, 6, 7} Fowler S.J....Lipworth B.J. (2002)
Pharmacogenetic association between ALOX5 promoter genotype and the response to anti-asthma treatment. (PubMed id 10369259)^{1, 6, 7} Drazen J.M....Drajesk J. (1999)
Characterization of the human 5-lipoxygenase gene. (PubMed id 2565035)^{2, 3, 4} Funk C.D.... Samuelsson B. (1989)
Protein kinase A inhibits leukotriene synthesis by phosphorylation of 5-lipoxygenase on serine 523. (PubMed id 15280375)^{1, 3, 4} Luo M....Brock T.G. (2004)
Phosphorylation of serine 271 on 5-lipoxygenase and its role in nuclear export. (PubMed id 18978352)^{1, 3, 4} Flamand N....Brock T.G. (2009)
Arachidonic acid regulates the translocation of 5-lipoxygenase to the nuclear membranes in human neutrophils. (PubMed id 16275640)^{1, 3, 4} Flamand N....Borgeat P. (2006)
Arachidonic acid promotes phosphorylation of 5-lipoxygenase at Ser- 271 by MAPK-activated protein kinase 2 (MK2). (PubMed id 11844797)^{1, 3, 4} Werz O.... Radmark O. (2002)
ALOX5 promoter genotype, asthma severity and LTC production by eosinophils. (PubMed id 16364163)^{1, 3, 6} Kalayci O....Lilly C. (2006)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 240	HGNC: 435	AceView: ALOX5	Ensembl:ENSG00000012779	euGenes: HUgn240
ECgene: ALOX5	H-InvDB: ALOX5

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
ATLAS Chromosomes in Cancer entry for ALOX5	Genetics and Cytogenetics in Oncology and Haematology

Licensable Technologies for ALOX5
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for ALOX5:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for ALOX5-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for ALOX5		Antibodies for ALOX5
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for ALOX5		Small molecules for ALOX5
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Recombinant Proteins (ALOX5)
	Antibodies (ALOX5)
	Chimera RNAi (ALOX5)
	Custom Service for Mouse Mab
	Custom Service for Rabbit Pab from Full-length Protein

Antibodies & Assays for ALOX5 (5-Lipoxygenase)

	Recombinant Proteins (5 Lipoxygenase)
	Antibodies (5 Lipoxygenase)

	Tagged/untagged cDNA clones
	Validated SYBR primer pairs
	Purified proteins from HEK293T cells
	Western blot validated antibodies
	shRNA in GFP-retroviral vector

Tocris compounds for ALOX5

	Drugs/Proteins for ALOX5
	Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Antibodies for ALOX5

GeneCards Homepage - Last full update: 2 Jul 2009 Incremental update: 13 Oct 2009

Random Gene From GIFtS :

about GIFtS

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Developed at the Crown Human Genome Center & Weizmann Institute of Science

The GeneCards Human Gene Database: Copyright © 1996-2009, Weizmann Institute of Science. All Rights Reserved.
ALOX5 Gene at Home site.
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ALOX5 Gene

protein-coding GIFtS: 69

Aliases &
Descriptions
for ALOX5

Summaries
for ALOX5

Genomic Location
for ALOX5

Proteins
for ALOX5

Protein Domains/
Families
for ALOX5

Gene Function
for ALOX5

Pathways & Interactions
for ALOX5

Drugs & Compounds
for ALOX5

Transcripts
for ALOX5

Expression
for ALOX5

Orthologs
for ALOX5

Paralogs
for ALOX5

SNPs/Variants
for ALOX5

Disorders & Mutations
for ALOX5

Medical News
for ALOX5

Publications
for ALOX5

Search for ALOX5

Genome Databases showing ALOX5

Other Databases showing ALOX5

Specialized Databases showing ALOX5

Licensable Technologies
for ALOX5

Services
for ALOX5

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

ALOX5 Gene

protein-coding GIFtS: 69

Aliases & Descriptionsfor ALOX5

Summariesfor ALOX5

Genomic Locationfor ALOX5

Proteinsfor ALOX5

Protein Domains/Familiesfor ALOX5

Gene Functionfor ALOX5

Pathways & Interactionsfor ALOX5

Drugs & Compoundsfor ALOX5

Transcriptsfor ALOX5

Expression for ALOX5

Orthologsfor ALOX5

Paralogsfor ALOX5

SNPs/Variantsfor ALOX5

Disorders & Mutationsfor ALOX5

Medical Newsfor ALOX5

Publicationsfor ALOX5

Search for ALOX5

Genome Databases showing ALOX5

Other Databases showing ALOX5

Specialized Databases showing ALOX5

Licensable Technologiesfor ALOX5

Servicesfor ALOX5

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for ALOX5

Summaries
for ALOX5

Genomic Location
for ALOX5

Proteins
for ALOX5

Protein Domains/
Families
for ALOX5

Gene Function
for ALOX5

Pathways & Interactions
for ALOX5

Drugs & Compounds
for ALOX5

Transcripts
for ALOX5

Expression
for ALOX5

Orthologs
for ALOX5

Paralogs
for ALOX5

SNPs/Variants
for ALOX5

Disorders & Mutations
for ALOX5

Medical News
for ALOX5

Publications
for ALOX5

Licensable Technologies
for ALOX5

Services
for ALOX5