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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

ALOX5 Gene

protein-coding GIFtS: 68
GCID: GC10P045869

arachidonate 5-lipoxygenase

Explore 130 diseases affiliated with
ALOX5 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Arachidonate 5-Lipoxygenase¹ ²		Arachidonic 5-Lipoxygenase Delta-10-13 Isoform²
5-LOX¹ ²		Arachidonic 5-Lipoxygenase Delta-13 Isoform²
5-LO² ³		Arachidonic 5-Lipoxygenase Delta-P10 Isoform²
LOG5² ³		Arachidonic Acid 5-Lipoxygenase²
EC 1.13.11.34³ ⁸		Leukotriene A4 Synthase²
5LPG²		5-Lipoxygenase¹
LOX-5²		EC 1.13.11⁸
Arachidonic 5-Lipoxygenase Alpha-10 Isoform²

External Ids:	HGNC: 435¹	Entrez Gene: 240²	Ensembl: ENSG00000012779⁷	OMIM: 152390⁵	UniProtKB: P09917³

Export aliases for ALOX5 gene to outside databases

Previous GC identifers: GC10P045171 GC10P045338 GC10P045644 GC10P045153 GC10P045189 GC10P042394

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for ALOX5:

This gene encodes a member of the lipoxygenase gene family and plays a dual role in the synthesis of leukotrienes from

arachidonic acid. The encoded protein, which is expressed specifically in bone marrow-derived cells, catalyzes the

conversion of arachidonic acid to 5(S)-hydroperoxy-6-trans-8,11,14-cis-eicosatetraenoic acid, and further to the

allylic epoxide 5(S)-trans-7,9-trans-11,14-cis-eicosatetrenoic acid (leukotriene A4). Leukotrienes are important

mediators of a number of inflammatory and allergic conditions. Mutations in the promoter region of this gene lead to a

diminished response to antileukotriene drugs used in the treatment of asthma and may also be associated with

atherosclerosis and several cancers. Alternatively spliced transcript variants encoding different isoforms have been

found for this gene. (provided by RefSeq, Jan 2012)

UniProtKB/Swiss-Prot: LOX5_HUMAN, P09917

Function: Catalyzes the first step in leukotriene biosynthesis, and thereby plays a role in inflammatory processes

summary for ALOX5:

Lipoxygenases (LOXs) are a family of non-heme iron dioxygenases that are involved in the production and

metabolism of fatty acid hydroperoxidases. There are six lipoxygenase isozymes; 5-LOX, 12R-LOX, 12S-LOX,

15-LOX-1 and 15-LOX-2, which catalyze the regio-selective addition of oxygen into arachidonic acid, and

epidermal LOX (E-LOX) which metabolizes 12R-hydroperoxyeicosatetraenoic acid (12R-HPETE) to a specific

epoxyalcohol compound. Different isozymes have different physiological roles; 5-, 12R-, 12S- and 15-LOX-1

have proliferative, antiapoptotic and angiogenic functions whilst 15-LOX-2 has roles in differentiation,

growth arrest and the induction of apoptosis. E-LOX, the most divergent member of this family, is involved

in terminal differentiation of keratinocytes and has a major role in skin barrier function. Perturbations in

lipoxygenase enzymes have been implicated in various human diseases including bronchial asthma,

atherosclerosis, osteoporosis and some cancers.

Gene Wiki entry for ALOX5 (Arachidonate 5-lipoxygenase)

PharmGKB "VIP" summary for ALOX5

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000010.10 NC_018921.1 NT_033985.7

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the ALOX5 gene promoter:
GR Sp1 p53 AP-1 ATF-2 Egr-1 GR-alpha c-Jun
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: ALOX5 promoter sequence

Search SABiosciences Chromatin IP Primers for ALOX5

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ALOX5

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10q11.2 Ensembl cytogenetic band: 10q11.21 HGNC cytogenetic band: 10q11.2

ALOX5 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ALOX5 gene location

GeneLoc information about chromosome 10 GeneLoc Exon Structure

GeneLoc location for GC10P045869: view genomic region (about GC identifiers)

Start:	45,869,629 bp from pter	End:	45,941,565 bp from pter
Size:	71,937 bases	Orientation:	plus strand

1 alternative location:

Chr10+,PATCHES 45,877,660-45,949,596

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: LOX5_HUMAN, P09917 (See protein sequence)

Recommended Name: Arachidonate 5-lipoxygenase

Size: 674 amino acids; 77983 Da

Cofactor: Binds 1 iron ion per subunit

Cofactor: Binds 2 calcium ions per subunit (By similarity)

Subunit: Interacts with ALOX5AP and LTC4S. Interacts with COTL1, the interaction is required for stability and

efficient catalytic activity

Subcellular location: Cytoplasm. Nucleus matrix. Nucleus membrane; Peripheral membrane protein. Note=Shuttles between

cytoplasm and nucleus. Found exclusively in the nucleus, when phosphorylated on Ser-272. Calcium binding promotes

translocation from the cytosol and the nuclear matrix to the nuclear envelope and membrane association

5 PDB 3D structures from and Proteopedia for ALOX5:

2ABV (3D)

3O8Y (3D)

3V92 (3D)

3V98 (3D)

3V99 (3D)

Secondary accessions: Q5JQ14

Explore the universe of human proteins at neXtProt for ALOX5: NX_P09917

Post-translational modifications:

Serine phosphorylation by MAPKAPK2 is stimulated by arachidonic acid. Phosphorylation on Ser-523 by PKA has an

inhibitory effect. Phosphorylation on Ser-272 prevents export from the nucleus¹

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_P09917

4/14 DME Specific Peptides for ALOX5 (P09917) (see all 14)

WVRSSDF

NPVLIRRC

FGYQFLNG

HAAVNFGQY

ALOX5 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (3 alternative transcripts):

NP_000689.1 NP_001243082.1 NP_001243083.1

ENSEMBL proteins:

ENSP00000363512 ENSP00000437634

Reactome Protein details: P09917
Human Recombinant Protein Products for ALOX5:

	Browse Purified and Recombinant Proteins at EMD Millipore
	Browse R&D Systems for human recombinant proteins
	Enzo Life Sciences proteins for ALOX5
	OriGene Purified Protein: ALOX5 OriGene Protein Over-expression Lysate: ALOX5 OriGene Custom Protein Services for ALOX5
	GenScript Custom Purified and Recombinant Proteins Services for ALOX5
	Novus Biologicals ALOX5 Proteins Novus Biologicals ALOX5 Lysates
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for ALOX5

Gene Ontology (GO): 5/10 cellular component terms (GO ID links to tree view) (see all 10): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005625	soluble fraction	--	--
GO:0005634	nucleus	--	--
GO:0005635	nuclear envelope	IDA	19233132
GO:0005641	nuclear envelope lumen	IDA	8245774
GO:0005737	cytoplasm	--	--

ALOX5 for ontologies About GeneDecksing

ALOX5 Antibody Products:

	EMD Millipore Mono- and Polyclonal Antibodies for the study of ALOX5
	R&D Systems Antibodies for ALOX5 (5-Lipoxygenase)
	Cell Signaling Technology (CST) Antibodies for ALOX5 (5-LO)
	OriGene Antibodies (see all 2): ALOX5 OriGene Custom Antibody Services for ALOX5
	GenScript Custom Superior Antibodies Services for ALOX5
	Novus Biologicals ALOX5 Antibodies
	Abcam antibodies for ALOX5
	Uscn Antibodies for ALOX5
	ThermoFisher Antibody for ALOX5

Assay Products for ALOX5:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for ALOX5
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for ALOX5

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

ALOX5 for domains About GeneDecksing

5/7 InterPro domains/families (see all 7):

IPR020833 LipOase_Fe_BS

IPR013819 LipOase_C

IPR001024 LipOase_LH2

IPR008976 Lipase_LipOase

IPR020834 LipOase_CS

Graphical View of Domain Structure for InterPro Entry P09917

ProtoNet protein and cluster: P09917

3 Blocks protein families:

IPB000907 Lipoxygenase

IPB001024 Lipoxygenase

IPB001885 Mammalian lipoxygenase signature

UniProtKB/Swiss-Prot: LOX5_HUMAN, P09917

Similarity: Belongs to the lipoxygenase family

Similarity: Contains 1 lipoxygenase domain

Similarity: Contains 1 PLAT domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: LOX5_HUMAN, P09917

Function: Catalyzes the first step in leukotriene biosynthesis, and thereby plays a role in inflammatory processes

Catalytic activity: Arachidonate + O(2) = leukotriene A(4) + H(2)O

Genatlas biochemistry entry for ALOX5:

arachidonate-5-lipoxygenase,lipid peroxidating enzyme implicated in the pathogenesis of inflammatory disorders as well

as membrane remodeling,carcinogenesis,atheroma and asthma formation,involved in leukotriene metabolism

Enzyme Numbers (IUBMB): EC 1.13.11.34¹ ² EC 1.13.11²

Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004051	arachidonate 5-lipoxygenase activity	TAS	--
GO:0005506	iron ion binding	IDA	--
GO:0005515	protein binding	IPI	11297527
GO:0016165	lipoxygenase activity	IEA	--

ALOX5 for ontologies About GeneDecksing

Phenotypes:
7 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Alox5):

adipose tissue	cardiovascular system	cellular	hematopoietic system	homeostasis/metabolism
immune system	skeleton

ALOX5 for phenotypes About GeneDecksing

Animal Models:
Mouse knock-outs for ALOX5: Alox5^tm1Bhk Alox5^tm1Fun

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for ALOX5

miRNA Products:		OriGene 3'-UTR Clone: ALOX5 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ALOX5
		1 QIAGEN miScript miRNA Assays for microRNA that regulate ALOX5:
		hsa-miR-3121-3p
		SwitchGear 3'UTR luciferase reporter plasmid: ALOX5 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ALOX5 (see all 7) OriGene shRNA RFP: ALOX5 OriGene siRNA: ALOX5
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ALOX5
		Sirion Biotech Custom design and validation of potent shRNA sequences against ALOX5

Gene Editing Products:			DNA2.0 Custom Protein Engineering Service for ALOX5
			Sirion Biotech Customized adenovirus for overexpression of ALOX5 Sirion Biotech Customized adenovirus for potent knockdown of ALOX5

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ALOX5 (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ALOX5 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: ALOX5 (NM_000698)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for ALOX5
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ALOX5

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for ALOX5
		Search LifeMap BioReagents cell lines for ALOX5
		Sirion Biotech Customized stable knockdown cell line services for ALOX5 Sirion Biotech Customized inducible knockdown cell line services for ALOX5 Sirion Biotech Customized stable overexpressing cell line services for ALOX5 Sirion Biotech Customized inducible overexpressing cell line services for ALOX5

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ALOX5

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/10 super-pathways (see all 10) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Arachidonic acid metabolism

Arachidonic acid metabolism	1.00	HETE and HPETE biosynthesis and metabolism	0.39
Arachidonic acid metabolism	0.42	Eicosanoid Synthesis	0.31
HETE and HPETE biosynthesis and metabolism	0.39

Metabolism

	Metabolism	1.00			Metabolism of lipids and lipoproteins	0.34
	Metabolic pathways	0.38

leukotriene biosynthesis

	leukotriene biosynthesis	1.00			Leukotriene modifiers pathway, Pharmacodynamics	0.33
	Synthesis of Leukotrienes (LT) and Eoxins (EX)	0.47

Synthesis of 15-eicosatetraenoic acid derivatives

Synthesis of 5-eicosatetraenoic acids

0.33

Synthesis of Lipoxins (LX)

0.00

Lymphocyte Signaling

Lymphocyte Signaling

1.00

Pathway sources
See GeneCards unified pathways
Show all pathways

1 EMD Millipore Pathway for ALOX5

HETE and HPETE biosynthesis and metabolism

1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for ALOX5

all-trans-Retinoic Acid Signaling in Brain

2 Cell Signaling Technology (CST) Pathways for ALOX5

	Ca, cAMP and Lipid Signaling
	Lymphocyte Signaling

1 GeneGo (Thomson Reuters) Pathway for ALOX5

HETE and HPETE biosynthesis and metabolism

4 BioSystems Pathways for ALOX5

	Eicosanoid Synthesis
	Selenium Pathway
	IL-5 Signaling Pathway
	leukotriene biosynthesis

5/6 Reactome Pathways for ALOX5 (see all 6)

	Synthesis of Lipoxins (LX)
	Metabolism
	Synthesis of Leukotrienes (LT) and Eoxins (EX)
	Arachidonic acid metabolism
	Synthesis of 5-eicosatetraenoic acids

1 PharmGKB Pathway for ALOX5

Leukotriene modifiers pathway, Pharmacodynamics

3 Kegg Pathways (Kegg details for ALOX5):

	Arachidonic acid metabolism
	Metabolic pathways
	Toxoplasmosis

UniProtKB/Swiss-Prot: LOX5_HUMAN, P09917

Pathway: Lipid metabolism; leukotriene A4 biosynthesis

ALOX5 for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for ALOX5

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/51 Interacting proteins for ALOX5 (P09917^{1, 3} ENSP00000363512⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 51)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
COTL1	Q14019¹^,³, ENSP00000262428⁴	EBI-79934,EBI-79926 I2D: score=5 STRING: ENSP00000262428
TGFBRAP1	Q8WUH2³, ENSP00000258449⁴	I2D: score=4 STRING: ENSP00000258449
ALOX5AP	P20292³, ENSP00000369858⁴	I2D: score=3 STRING: ENSP00000369858
ACTB	P60709³, ENSP00000349960⁴	I2D: score=2 STRING: ENSP00000349960
MAPKAPK2	P49137³, ENSP00000356070⁴	I2D: score=2 STRING: ENSP00000356070

About this table

Gene Ontology (GO): 5/13 biological process terms (GO ID links to tree view) (see all 13): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0002526	acute inflammatory response	--	--
GO:0002540	leukotriene production involved in inflammatory response	IEA	--
GO:0006691	leukotriene metabolic process	TAS	3422434
GO:0006692	prostanoid metabolic process	--	--
GO:0006954	inflammatory response	--	--

ALOX5 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

ALOX5 for compounds About GeneDecksing

EMD Millipore small molecules for ALOX5:
Small Molecule - inhibitor

Enzo Life Sciences drugs & compounds for ALOX5

Compounds for ALOX5 available from Tocris Bioscience About this table

Compound	Action	CAS #
2-TEDC	5-, 12-, 15-Lipoxygenase inhibitor	[132465-10-2]
Baicalein	5- and 12-Lipoxygenase inhibitor	[491-67-8]
BAY-X 1005	Orally active 5-lipoxygenase activating protein (FLAP) inhibitor	[128253-31-6]
BW-B 70C	5-Lipoxygenase inhibitor	[134470-38-5]
Zileuton	Orally active 5-LOX inhibitor	[111406-87-2]

10/12 HMDB Compounds for ALOX5 (see all 12) About this table

Compound	Synonyms	CAS #	PubMed Ids
18R-HEPE	18(R)-hydroxyeicosa-5Z,8Z,11E,14Z,16E-pentaenoate (see all 3)	--	--
5(S)-Hydroperoxyeicosatetraenoic acid	5-hydroperoxy-6-trans-8,11,14-cis-eicosatetraenoic acid (see all 6)	71774-08-8	--
5-HPETE	5(S)-HPETE (see all 7)	74581-83-2	--
9(S)-HPODE		--	--
Arachidonic acid	5,8,11,14-Eicosatetraenoic acid (see all 16)	506-32-1	--
Caffeic acid	3,4-Dihydroxybenzeneacrylate (see all 9)	331-39-5	--
Calcium	Ca (see all 2)	7440-70-2	--
Iron	Armco iron (see all 19)	7439-89-6	--
Leukotriene A4	LTA4 (see all 10)	72059-45-1	--
Linoleic acid	(9Z,12Z)-9,12-Octadecadienoate (see all 26)	60-33-3	--

10/15 DrugBank Compounds for ALOX5 (see all 15) About this table

Compound	Synonyms	CAS #	Type	Actions	PubMed Ids
Zileuton	--	111406-87-2	target	inhibitor	10694244 11529688 8058773 11561080 17394438 19645854 11752352 10322101 8826571 20436887 10377029
Diethylcarbamazine	Carbamazine (see all 5)	90-89-1	target	inhibitor	3004501 1886988 11752352 1400062 8606397 10518442
Masoprocol	Dihydronorguaiaretic acid (see all 7)	500-38-9	target	inhibitor	11277534 15098224 15694390 11752352 15379894 11318430
Aminosalicylic Acid	4-aminosalicylic acid (see all 10)	65-49-6	target	inhibitor	6428914 6131674 2882965
Diclofenac	Diclofenac Acid (see all 4)	15307-86-5	target	potentiator	15525540 12826271 12932896
Mesalazine	5-aminosalicylate (see all 4)	89-57-6	target	inhibitor	6428914 6131674 2882965
Minocycline	--	10118-90-8	target	inhibitor	17506934 16574083 15371729
Sulfasalazine	Sulfasalazin (see all 2)	599-79-1	target	inhibitor	6428914 6131674 2882965
Balsalazide	Balsalazida [Spanish] (see all 4)	80573-04-2	target	inhibitor	1359745 19743890
Meclofenamic acid	Acide meclofenamique [INN-French] (see all 6)	644-62-2	target	inhibitor	1539679 3020588

10/144 Novoseek chemical compound relationships for ALOX5 gene (see all 144) About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
leukotriene b4	95.7	449	14530386 (6), 1330161 (5), 1314503 (4), 9142859 (4) (see all 99)
zileuton	95.7	160	11561080 (4), 8826571 (3), 7551371 (3), 8620667 (2) (see all 99)
arachidonic acid	94	889	16275640 (8), 8049076 (6), 7577949 (4), 11867685 (4) (see all 99)
5-hydroxyeicosatetraenoic acid	92.8	60	8358023 (3), 9789062 (3), 1328141 (1), 8223906 (1) (see all 32)
mk 886	91.1	50	2104841 (4), 8917356 (2), 19862483 (2), 15779087 (2) (see all 36)
aa861	89.7	38	8223906 (2), 1330136 (2), 7766427 (1), 8596775 (1) (see all 27)
ltc4	88.8	84	7900879 (3), 10102384 (3), 9296112 (2), 9431445 (2) (see all 50)
5-hpete	88.5	37	8395245 (4), 7811715 (3), 8164257 (2), 1848236 (2) (see all 18)
licofelone	88.3	45	17704828 (10), 18268076 (2), 11550975 (2), 15498796 (2) (see all 13)
lte4	86.5	29	19336727 (3), 15519606 (2), 2153812 (1), 9596112 (1) (see all 18)

1 PharmGKB related drug/compound annotation for ALOX5 gene About this table

Drug/compound	PharmGKB Annotation
montelukast	CA

Search CenterWatch for drugs/clinical trials and news about ALOX5 / LOX5

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for ALOX5 gene (3 alternative transcripts):

NM_000698.3 NM_001256153.1 NM_001256154.1

Unigene Cluster for ALOX5:

Arachidonate 5-lipoxygenase

Hs.89499 [show with all ESTs]

Unigene Representative Sequence: NM_000698

7 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000374391(uc001jce.3 uc009xmt.3 uc010qfg.2 uc021ppr.1)

ENST00000483623 ENST00000475300 ENST00000493336 ENST00000481117 ENST00000498461

ENST00000542434

miRNA Products:		OriGene 3'-UTR Clone: ALOX5 Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ALOX5
		1 QIAGEN miScript miRNA Assays for microRNA that regulate ALOX5:
		hsa-miR-3121-3p
		SwitchGear 3'UTR luciferase reporter plasmid: ALOX5 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ALOX5 (see all 7) OriGene shRNA RFP: ALOX5 OriGene siRNA: ALOX5
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ALOX5
		Sirion Biotech Custom design and validation of potent shRNA sequences against ALOX5

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ALOX5 (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ALOX5 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: ALOX5 (NM_000698)
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Additional cDNA sequence:

AK225603.1 AK315223.1 BC034464.1 BC040450.1 BC130332.1 BC132677.1 BC143985.1 BC143986.1

J03571.1 J03600.1 JQ728550.1

8 DOTS entries:

DT.449694 DT.92427412 DT.95193567 DT.97806426 DT.100771760 DT.210270 DT.86839247 DT.95142328

24/177 AceView cDNA sequences (see all 177):

BI837266 BX346381 BE710304 CA439600 BM726803 AI798007 AI380545 BC040450

AA926891 AA767516 AA587201 BX386145 CA390028 BQ786870 AI075284 AA315865

BI822076 BC034464 AI799008 BE676451 BQ787144 BX377162 AA505143 AI698814

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

ALOX5 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GGATGATTAT

About this image

ALOX5 expression in embryonic tissues and stem cells
Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

2 LifeMap In Vivo Development Anatomical Compartments/Cells

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Ovary

Antral Follicle

Cumulus Cells

Ovary

Umbilical Cord

Umbilical Veins

Umbilical Cord

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

Stem Cell Differentiation: 1 LifeMap Cell

Name

Category

PureStem™ progenitor EN2 (Embryonic Progenitor Cell)

See ALOX5 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for ALOX5

SOURCE GeneReport for Unigene cluster: Hs.89499

SABiosciences Expression via Pathway-Focused PCR Arrays including ALOX5 (see all 6):

Hypertension in human mouse rat

Endothelial Cell Biology in human mouse rat

Leukemia in human mouse rat

Insulin Resistance in human mouse rat

Drug Metabolism in human mouse rat

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In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ALOX5

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of eukaryotes.

Orthologs for ALOX5 gene from 6/20 species (see all 20) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Alox5^{1 , 5}	arachidonate 5-lipoxygenase^{1, 5}	87.88(n)¹ 93.47(a)¹		6 (53.79 cM)⁵ 11689¹ NM_009662.2¹ NP_033792.1¹ 116410077⁵
chicken (Gallus gallus)	Aves	ALOX5¹	arachidonate 5-lipoxygenase	76.85(n) 83.68(a)		423769 XM_003641512.1 XP_003641560.1
lizard (Anolis carolinensis)	Reptilia	-- --	--	80(a) 42(a)	1 ↔ 1 possible ortholog	4(74264020-74281182) AAWZ02041946(11-4637)
zebrafish (Danio rerio)	Actinopterygii	alox5¹	arachidonate 5-lipoxygenase	70.08(n) 74.48(a)		567204 XM_690495.3 XP_695587.2
thale cress (Arabidopsis thaliana)	eudicotyledons	LOX5¹	lipoxygenase 5	44.09(n) 33.47(a)		821808 NM_113137.3 NP_188879.2
rice (Oryza sativa)	Liliopsida	Os03g0738600¹	hypothetical protein	49.85(n) 33.48(a)		4334049 NM_001057747.1 NP_001051212.1

ENSEMBL Gene Tree for ALOX5 (if available)
TreeFam Gene Tree for ALOX5 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for ALOX5 gene

ALOX12B² ALOX15B² ALOX12² ALOX15² ALOXE3²

7 SIMAP similar genes for ALOX5 using alignment to 6 protein entries: LOX5_HUMAN (see all proteins):

arachidonate 12-lipoxygenase ALOX15B ALOX12 ALOX15 ALOX12B ALOXE3

LOXHD1

ALOX5 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 10 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs146362560^1,2	C,F	untested	42461541(+)	`ATCCCG/AGGAGA`	6	/P	syn¹		1		NA	4550
rs72789720^1,2	C	--	42393136(+)	`ATTCTA/GTAATT`	3	--	us2k¹		0	--	--	--	--
rs4986834^1,2	C,F	--	42393283(+)	`TGTACA/GTTACA`	3	--	us2k¹		5		MN	400
rs72789721^1,2	C	--	42393382(+)	`GAAAAG/TAATAA`	3	--	us2k¹		0	--	--	--	--
rs76748216^1,2		--	42393508(+)	`GAAAAG/ACTAAA`	3	--	us2k¹		1		WA	118
rs114446477^1,2	C,F	--	42394155(+)	`AAACCT/ATCTCC`	3	--	us2k¹		1		WA	118
rs77185151^1,2	F	--	42394234(+)	`AGCCCC/GGCATG`	3	--	us2k¹		1		EA	120
rs73283136^1,2	C	--	42394582(+)	`AGGAGC/TCTGGC`	3	--	us2k¹		1		WA	2
rs78137087^1,2		--	42394929(+)	`AGATGC/TGGACA`	3	--	ut5¹		3		NA EA	242
rs76739827^1,2	C	--	42395079(+)	`GGCGGA/GCTGCA`	6	D G	mis¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for ALOX5 (45869629 - 45941565 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for ALOX5
1 CNV: 100936
Human Gene Mutation Database (HGMD): ALOX5

SABiosciences Cancer Mutation PCR Assays

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

ALOX5 for disorders           About GeneDecksing

OMIM gene information: 152390
OMIM disorders: 600807
20/130 diseases for ALOX5 (see all 130):    About MalaCards

asthma, diminished response to antileukotriene treatment in bronchial asthma asthma atherosclerosis

osteoporosis glutathione synthetase deficiency churg-strauss syndrome sjogren-larsson syndrome

adult respiratory distress syndrome arthus reaction abdominal aortic aneurysm primary pulmonary hypertension

clear cell renal cell carcinoma allergic rhinitis aortic aneurysm tuberculous meningitis

transient cerebral ischemia inflammatory bowel disease wegener's granulomatosis bullous pemphigoid

4 diseases from the University of Copenhagen DISEASES database for ALOX5:

Asthma Atherosclerosis Arthritis Pleurisy

10/94 Novoseek disease relationships for ALOX5 gene (see all 94) About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
asthma	72.7	180	8473681 (4), 8129222 (4), 16364163 (4), 8598621 (4) (see all 98)
inflammation	68.1	116	16250846 (3), 1309754 (2), 12733982 (2), 17305572 (2) (see all 90)
leukemia basophilic	60.2	16	8071328 (2), 12005204 (1), 8140120 (1), 19243697 (1) (see all 12)
asthma exercise-induced	59.4	5	8630575 (2), 16027142 (1), 10984370 (1), 17481554 (1)
ear edema	59.3	4	1665293 (2), 7916384 (1), 9599246 (1)
allergic rhinitis	50.8	7	12607939 (1), 9809497 (1), 9444606 (1), 1701029 (1) (see all 6)
atherosclerosis	47	50	17481551 (2), 14702425 (2), 18842779 (2), 17825794 (2) (see all 31)
anaphylaxis	46.7	9	8081074 (3), 1949224 (1), 8480540 (1), 9532969 (1) (see all 6)
asthma allergic	45.2	7	8994519 (1), 9444606 (1), 1851340 (1), 17481554 (1) (see all 6)
edema	44.7	20	7541689 (2), 1478686 (2), 8032607 (2), 9444606 (1) (see all 12)

Genetic Association Database (GAD): ALOX5
Human Genome Epidemiology (HuGE) Navigator: ALOX5 (78 documents)

Export disorders for ALOX5 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for ALOX5 gene, integrated from 9 sources (see all 1358):
(articles sorted by number of sources associating them with ALOX5)

Utopia: connect your pdf to the dynamic
world of online information

Arachidonate lipoxygenase (ALOX) and cyclooxygenase (COX) polymorphisms and colon cancer risk. (PubMed id 15308583)^{1, 2, 4} Goodman J.E.... Harris C.C. (2004)
Characterization of the human 5-lipoxygenase gene. (PubMed id 2565035)^{1, 2, 3} Funk C.D.... Samuelsson B. (1989)
Protein kinase A inhibits leukotriene synthesis by phosphorylation of 5-lipoxygenase on serine 523. (PubMed id 15280375)^{1, 2, 9} Luo M....Brock T.G. (2004)
Coactosin-like protein functions as a stabilizing cha perone for 5-lipoxygenase: role of tryptophan 102. (PubMed id 19807693)^{1, 2, 9} Esser J....RAYdmark O. (2010)
Phosphorylation of serine 271 on 5-lipoxygenase and its role in nuclear export. (PubMed id 18978352)^{1, 2, 9} Flamand N.... Brock T.G. (2009)
Arachidonic acid regulates the translocation of 5-lipoxygenase to the nuclear membranes in human neutrophils. (PubMed id 16275640)^{1, 2, 9} Flamand N....Borgeat P. (2006)
Arachidonic acid promotes phosphorylation of 5-lipoxygenase at Ser- 271 by MAPK-activated protein kinase 2 (MK2). (PubMed id 11844797)^{1, 2, 9} Werz O.... Radmark O. (2002)
ALOX5 promoter genotype, asthma severity and LTC production by eosinophils. (PubMed id 16364163)^{1, 4, 9} Kalayci O....Lilly C. (2006)
5-lipoxygenase and 5-lipoxygenase-activating protein are localized in the nuclear envelope of activated human leukocytes. (PubMed id 8245774)^{1, 2, 9} Woods J.W....Singer I.I. (1993)
Evaluation of the role of conserved His and Met residues among lipoxygenases by site-directed mutagenesis of recombinant human 5- lipoxygenase. (PubMed id 1939225)^{1, 2, 9} Nguyen T.... Riendeau D. (1991)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 240	HGNC: 435	AceView: ALOX5	Ensembl:ENSG00000012779	euGenes: HUgn240
ECgene: ALOX5	Kegg: 240	H-InvDB: ALOX5

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for ALOX5	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for ALOX5	Genetics and Cytogenetics in Oncology and Haematology

Intellectual Property for ALOX5 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for ALOX5 gene:
Search GeneIP for patents involving ALOX5

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section

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ALOX5 Gene

arachidonate 5-lipoxygenase

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ALOX5 Gene

arachidonate 5-lipoxygenase

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