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Aliases for ALOX5 Gene

Aliases for ALOX5 Gene

  • Arachidonate 5-Lipoxygenase 2 3 5
  • EC 1.13.11.34 4 61
  • 5-LO 3 4
  • LOG5 3 4
  • Arachidonic 5-Lipoxygenase Delta-10-13 Isoform 3
  • Arachidonic 5-Lipoxygenase Delta-P10 Isoform 3
  • Arachidonic 5-Lipoxygenase Alpha-10 Isoform 3
  • Arachidonic 5-Lipoxygenase Delta-13 Isoform 3
  • Arachidonic Acid 5-Lipoxygenase 3
  • Leukotriene A4 Synthase 3
  • 5-Lipoxygenase 4
  • EC 1.13.11 61
  • 5-LOX 3
  • LOX-5 3
  • 5LPG 3

External Ids for ALOX5 Gene

Previous GeneCards Identifiers for ALOX5 Gene

  • GC10P045171
  • GC10P045644
  • GC10P045153
  • GC10P045189
  • GC10P045869
  • GC10P042394

Summaries for ALOX5 Gene

Entrez Gene Summary for ALOX5 Gene

  • This gene encodes a member of the lipoxygenase gene family and plays a dual role in the synthesis of leukotrienes from arachidonic acid. The encoded protein, which is expressed specifically in bone marrow-derived cells, catalyzes the conversion of arachidonic acid to 5(S)-hydroperoxy-6-trans-8,11,14-cis-eicosatetraenoic acid, and further to the allylic epoxide 5(S)-trans-7,9-trans-11,14-cis-eicosatetrenoic acid (leukotriene A4). Leukotrienes are important mediators of a number of inflammatory and allergic conditions. Mutations in the promoter region of this gene lead to a diminished response to antileukotriene drugs used in the treatment of asthma and may also be associated with atherosclerosis and several cancers. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012]

GeneCards Summary for ALOX5 Gene

ALOX5 (Arachidonate 5-Lipoxygenase) is a Protein Coding gene. Diseases associated with ALOX5 include Asthma and Arthus Reaction. Among its related pathways are Arachidonic acid metabolism and Circadian entrainment. GO annotations related to this gene include iron ion binding and arachidonate 5-lipoxygenase activity. An important paralog of this gene is ALOX15B.

UniProtKB/Swiss-Prot for ALOX5 Gene

  • Catalyzes the first step in leukotriene biosynthesis, and thereby plays a role in inflammatory processes.

Tocris Summary for ALOX5 Gene

  • Lipoxygenases (LOXs) are a family of non-heme iron dioxygenases that are involved in the production and metabolism of fatty acid hydroperoxidases. There are six lipoxygenase isozymes; 5-LOX, 12R-LOX, 12S-LOX, 15-LOX-1, 15-LOX-2 and E-LOX.

Gene Wiki entry for ALOX5 Gene

PharmGKB "VIP" Summary for ALOX5 Gene

No data available for fRNAdb sequence ontologies and piRNA Summary for ALOX5 Gene

Genomics for ALOX5 Gene

Regulatory Elements for ALOX5 Gene

Enhancers for ALOX5 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
- Elite enhancer/Elite enhancer-gene association

Enhancers around ALOX5 on UCSC Golden Path with GeneCards custom track

Promoters for ALOX5 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

Genomic Location for ALOX5 Gene

Chromosome:
10
Start:
45,374,176 bp from pter
End:
45,446,121 bp from pter
Size:
71,946 bases
Orientation:
Plus strand

Genomic View for ALOX5 Gene

Genes around ALOX5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ALOX5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ALOX5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ALOX5 Gene

Proteins for ALOX5 Gene

  • Protein details for ALOX5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P09917-LOX5_HUMAN
    Recommended name:
    Arachidonate 5-lipoxygenase
    Protein Accession:
    P09917
    Secondary Accessions:
    • B7ZLS0
    • E5FPY5
    • E5FPY7
    • E5FPY8
    • Q5JQ14

    Protein attributes for ALOX5 Gene

    Size:
    674 amino acids
    Molecular mass:
    77983 Da
    Cofactor:
    Name=Ca(2+); Xref=ChEBI:CHEBI:29108;
    Cofactor:
    Name=Fe cation; Xref=ChEBI:CHEBI:24875;
    Quaternary structure:
    • Interacts with ALOX5AP and LTC4S. Interacts with COTL1, the interaction is required for stability and efficient catalytic activity.

    Three dimensional structures from OCA and Proteopedia for ALOX5 Gene

    Alternative splice isoforms for ALOX5 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ALOX5 Gene

Post-translational modifications for ALOX5 Gene

  • Serine phosphorylation by MAPKAPK2 is stimulated by arachidonic acid. Phosphorylation on Ser-523 by PKA has an inhibitory effect. Phosphorylation on Ser-272 prevents export from the nucleus.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ALOX5 Gene

Domains & Families for ALOX5 Gene

Gene Families for ALOX5 Gene

Graphical View of Domain Structure for InterPro Entry

P09917

UniProtKB/Swiss-Prot:

LOX5_HUMAN :
  • Contains 1 lipoxygenase domain.
  • Belongs to the lipoxygenase family.
Domain:
  • Contains 1 lipoxygenase domain.
  • Contains 1 PLAT domain.
Family:
  • Belongs to the lipoxygenase family.
genes like me logo Genes that share domains with ALOX5: view

Function for ALOX5 Gene

Molecular function for ALOX5 Gene

GENATLAS Biochemistry:
arachidonate-5-lipoxygenase,lipid peroxidating enzyme implicated in the pathogenesis of inflammatory disorders as well as membrane remodeling,carcinogenesis,atheroma and asthma formation,involved in leukotriene metabolism
UniProtKB/Swiss-Prot CatalyticActivity:
Arachidonate + O(2) = leukotriene A(4) + H(2)O.
UniProtKB/Swiss-Prot Function:
Catalyzes the first step in leukotriene biosynthesis, and thereby plays a role in inflammatory processes.

Enzyme Numbers (IUBMB) for ALOX5 Gene

Gene Ontology (GO) - Molecular Function for ALOX5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004051 arachidonate 5-lipoxygenase activity IDA 21233389
GO:0005506 iron ion binding IDA 21233389
GO:0005515 protein binding IPI 11297527
genes like me logo Genes that share ontologies with ALOX5: view
genes like me logo Genes that share phenotypes with ALOX5: view

Animal Models for ALOX5 Gene

MGI Knock Outs for ALOX5:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for ALOX5 Gene

Localization for ALOX5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ALOX5 Gene

Cytoplasm. Nucleus matrix. Nucleus membrane; Peripheral membrane protein. Note=Shuttles between cytoplasm and nucleus. Found exclusively in the nucleus, when phosphorylated on Ser-272. Calcium binding promotes translocation from the cytosol and the nuclear matrix to the nuclear envelope and membrane association.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ALOX5 Gene COMPARTMENTS Subcellular localization image for ALOX5 gene
Compartment Confidence
cytosol 5
extracellular 5
nucleus 5
plasma membrane 3
mitochondrion 2
cytoskeleton 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for ALOX5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IDA 22664934
GO:0005634 nucleus IEA --
GO:0005635 nuclear envelope TAS --
GO:0005641 nuclear envelope lumen IDA 8245774
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with ALOX5: view

Pathways & Interactions for ALOX5 Gene

genes like me logo Genes that share pathways with ALOX5: view

UniProtKB/Swiss-Prot P09917-LOX5_HUMAN

  • Pathway: Lipid metabolism; leukotriene A4 biosynthesis.

Gene Ontology (GO) - Biological Process for ALOX5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002526 acute inflammatory response IEA --
GO:0002540 leukotriene production involved in inflammatory response IEA --
GO:0006691 leukotriene metabolic process TAS --
GO:0006954 inflammatory response IEA --
GO:0007584 response to nutrient IEA --
genes like me logo Genes that share ontologies with ALOX5: view

No data available for SIGNOR curated interactions for ALOX5 Gene

Drugs & Compounds for ALOX5 Gene

(96) Drugs for ALOX5 Gene - From: DrugBank, PharmGKB, ApexBio, DGIdb, FDA Approved Drugs, IUPHAR, HMDB, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Zileuton Approved, Investigational, Withdrawn Pharma Inhibition, Inhibitor, inhibitor, Target 5-lipoxygenase (5-LOX) inhibitor, orally active, Orally active 5-LOX inhibitor 20
montelukast Approved Pharma Antagonist, Target, other/unknown 266
Balsalazide Approved, Investigational Pharma inhibitor, Target 7
Meclofenamic acid Approved, Vet_approved Pharma inhibitor, Target 1
Mesalazine Approved Pharma inhibitor, Target 0

(85) Additional Compounds for ALOX5 Gene - From: HMDB and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
5-Hpete
  • (5S,6E,8Z,11Z,14Z)-5-hydroperoxyicosa-6,8,11,14-tetraenoate
  • (5S,6E,8Z,11Z,14Z)-5-hydroperoxyicosa-6,8,11,14-tetraenoic acid
  • (6E,8Z,11Z,14Z)-(5S)-5-Hydroperoxyeicosa-6,8,11,14-tetraenoate
  • (6E,8Z,11Z,14Z)-(5S)-5-Hydroperoxyeicosa-6,8,11,14-tetraenoic acid
  • 5(S)-HPETE
74581-83-2
4'-Hydroxydiclofenac
  • (O-(2,6-Dichloro-4-hydroxyanilino)phenyl)acetic acid
  • 4'-Hydroxy diclofenac
  • 4'-OH DCF
  • {2-[(2,6-dichloro-4-hydroxyphenyl)amino]phenyl}acetic acid
64118-84-9
5(S)-Hydroperoxyeicosatetraenoic acid
  • (6E,8Z,11Z,14Z)-(5S)-5-hydroperoxyeicosa-6,8,11,14-tetraenoate
  • (6E,8Z,11Z,14Z)-(5S)-5-hydroperoxyeicosa-6,8,11,14-tetraenoic acid
  • 5(S)-Hydroperoxy-6-trans-8,11,14-cis-eicosatetraenoate
  • 5(S)-Hydroperoxy-6-trans-8,11,14-cis-eicosatetraenoic acid
  • 5-Hydroperoxy-6-trans-8,11,14-cis-eicosatetraenoate
71774-08-8
9(S)-HPODE
Fe2+
  • Armco iron
  • Carbonyl iron
  • FE
  • Ferrovac e
  • Hematite
15438-31-0

(5) Tocris Compounds for ALOX5 Gene

Compound Action Cas Number
2-TEDC 5-, 12-, 15-Lipoxygenase inhibitor 132465-10-2
BW-B 70C 5-Lipoxygenase inhibitor 134470-38-5
MK 886 Inhibitor of 5-lipoxygenase-activating protein (FLAP) 118414-82-7
PD 146176 Selective 15-lipoxygenase inhibitor 4079-26-9
Zileuton Orally active 5-LOX inhibitor 111406-87-2

(10) ApexBio Compounds for ALOX5 Gene

Compound Action Cas Number
2-TEDC 132465-10-2
BAY-X 1005 Potent FLAP inhibitor 128253-31-6
Butein Protein kinase inhibitor 487-52-5
BW-B 70C 5-Lipoxygenase inhibitor,potent and selective 134470-38-5
Malotilate Tyrosine kinase inhibitors 59937-28-9
MK 886 118414-82-7
PD 146176 4079-26-9
U-73122 112648-68-7
Zileuton 5-lipoxygenase (5-LOX) inhibitor, orally active 111406-87-2
Zileuton sodium 5-lipoxygenase and leukotrienes inhibitor 118569-21-4
genes like me logo Genes that share compounds with ALOX5: view

Drug Products

Transcripts for ALOX5 Gene

Unigene Clusters for ALOX5 Gene

Arachidonate 5-lipoxygenase:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ALOX5 Gene

No ASD Table

Relevant External Links for ALOX5 Gene

GeneLoc Exon Structure for
ALOX5
ECgene alternative splicing isoforms for
ALOX5

Expression for ALOX5 Gene

mRNA expression in normal human tissues for ALOX5 Gene

mRNA differential expression in normal tissues according to GTEx for ALOX5 Gene

This gene is overexpressed in Whole Blood (x28.6).

Protein differential expression in normal tissues from HIPED for ALOX5 Gene

This gene is overexpressed in Lymph node (23.1) and Peripheral blood mononuclear cells (17.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for ALOX5 Gene



Protein tissue co-expression partners for ALOX5 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ALOX5 Gene:

ALOX5

SOURCE GeneReport for Unigene cluster for ALOX5 Gene:

Hs.89499
genes like me logo Genes that share expression patterns with ALOX5: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for ALOX5 Gene

Orthologs for ALOX5 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for ALOX5 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia ALOX5 34
  • 90.11 (n)
  • 91.99 (a)
ALOX5 35
  • 92 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ALOX5 34
  • 90.16 (n)
  • 93.62 (a)
ALOX5 35
  • 93 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Alox5 34
  • 87.88 (n)
  • 93.47 (a)
Alox5 16
Alox5 35
  • 93 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia ALOX5 34
  • 97.42 (n)
  • 97.02 (a)
ALOX5 35
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Alox5 34
  • 86.29 (n)
  • 92.94 (a)
oppossum
(Monodelphis domestica)
Mammalia ALOX5 35
  • 90 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ALOX5 35
  • 92 (a)
OneToOne
chicken
(Gallus gallus)
Aves ALOX5 34
  • 76.85 (n)
  • 83.68 (a)
ALOX5 35
  • 84 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ALOX5 35
  • 80 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia alox5 34
  • 71.07 (n)
  • 78.19 (a)
zebrafish
(Danio rerio)
Actinopterygii alox5a 34
  • 70.18 (n)
  • 74.63 (a)
ALOX5 (1 of 4) 35
  • 58 (a)
OneToMany
alox5a 35
  • 74 (a)
OneToMany
alox5b.2 35
  • 57 (a)
OneToMany
alox5b.3 35
  • 59 (a)
OneToMany
thale cress
(Arabidopsis thaliana)
eudicotyledons LOX5 34
  • 44.58 (n)
  • 33.73 (a)
rice
(Oryza sativa)
Liliopsida Os03g0699700 34
  • 46.5 (n)
  • 34.31 (a)
corn
(Zea mays)
Liliopsida Zm.14487 34
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 31 (a)
ManyToMany
-- 35
  • 38 (a)
ManyToMany
-- 35
  • 32 (a)
ManyToMany
CSA.6148 35
  • 35 (a)
ManyToMany
Species where no ortholog for ALOX5 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ALOX5 Gene

ENSEMBL:
Gene Tree for ALOX5 (if available)
TreeFam:
Gene Tree for ALOX5 (if available)

Paralogs for ALOX5 Gene

Paralogs for ALOX5 Gene

(5) SIMAP similar genes for ALOX5 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with ALOX5: view

Variants for ALOX5 Gene

Sequence variations from dbSNP and Humsavar for ALOX5 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type
VAR_028018 -

Structural Variations from Database of Genomic Variants (DGV) for ALOX5 Gene

Variant ID Type Subtype PubMed ID
esv2513283 CNV deletion 19546169
esv2567160 CNV deletion 19546169
esv3891797 CNV gain 25118596
nsv1043536 CNV gain 25217958
nsv466910 CNV loss 19166990
nsv550715 CNV loss 21841781

Variation tolerance for ALOX5 Gene

Residual Variation Intolerance Score: 8.22% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.03; 37.34% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ALOX5 Gene

Human Gene Mutation Database (HGMD)
ALOX5
SNPedia medical, phenotypic, and genealogical associations of SNPs for
ALOX5

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ALOX5 Gene

Disorders for ALOX5 Gene

MalaCards: The human disease database

(12) MalaCards diseases for ALOX5 Gene - From: OMIM, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
asthma
  • asthma, protection against
arthus reaction
  • arthus phenomenon
asthma 1
  • asthma-related traits 1
paranasal sinus disease
  • disorder of nasal sinus
glutathione synthetase deficiency
  • 5-oxoprolinase deficiency
- elite association - COSMIC cancer census association via MalaCards
Search ALOX5 in MalaCards View complete list of genes associated with diseases

Relevant External Links for ALOX5

Genetic Association Database (GAD)
ALOX5
Human Genome Epidemiology (HuGE) Navigator
ALOX5
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ALOX5
genes like me logo Genes that share disorders with ALOX5: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ALOX5 Gene

Publications for ALOX5 Gene

  1. Coactosin-like protein functions as a stabilizing chaperone for 5- lipoxygenase: role of tryptophan 102. (PMID: 19807693) Esser J. … Radmark O. (Biochem. J. 2010) 3 4 22 65
  2. Phosphorylation of serine 271 on 5-lipoxygenase and its role in nuclear export. (PMID: 18978352) Flamand N. … Brock T.G. (J. Biol. Chem. 2009) 3 4 22 65
  3. 5-lipoxygenase pharmacogenetics in asthma: overlap with Cys-leukotriene receptor antagonist loci. (PMID: 19214143) Tantisira K.G. … Weiss S.T. (Pharmacogenet. Genomics 2009) 3 22 46 65
  4. Association studies of ALOX5 and bone mineral density in healthy adults. (PMID: 17909879) Foroud T. … Econs M.J. (Osteoporos Int 2008) 3 22 46 65
  5. Arachidonate 5-lipoxygenase (5-LO) promoter genotype and risk of myocardial infarction: a case-control study. (PMID: 18179798) Maznyczka A. … Samani N.J. (Atherosclerosis 2008) 3 22 46 65

Products for ALOX5 Gene

Sources for ALOX5 Gene

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