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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ALOX5 Gene

protein-coding   GIFtS: 70
GCID: GC10P045869

Arachidonate 5-Lipoxygenase

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Arachidonate 5-Lipoxygenase1 2     Arachidonic 5-Lipoxygenase Delta-10-13 Isoform2
5-LO2 3     Arachidonic 5-Lipoxygenase Delta-13 Isoform2
LOG52 3     Arachidonic 5-Lipoxygenase Delta-P10 Isoform2
EC 1.13.11.343 8     Arachidonic Acid 5-Lipoxygenase2
5-LOX2     Leukotriene A4 Synthase2
5LPG2     5-lipoxygenase3
LOX-52     EC 1.13.118
Arachidonic 5-Lipoxygenase Alpha-10 Isoform2     

External Ids:    HGNC: 4351   Entrez Gene: 2402   Ensembl: ENSG000000127797   OMIM: 1523905   UniProtKB: P099173   

Export aliases for ALOX5 gene to outside databases

Previous GC identifers: GC10P045171 GC10P045338 GC10P045644 GC10P045153 GC10P045189 GC10P042394


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for ALOX5 Gene:
This gene encodes a member of the lipoxygenase gene family and plays a dual role in the synthesis of leukotrienes
from arachidonic acid. The encoded protein, which is expressed specifically in bone marrow-derived cells,
catalyzes the conversion of arachidonic acid to 5(S)-hydroperoxy-6-trans-8,11,14-cis-eicosatetraenoic acid, and
further to the allylic epoxide 5(S)-trans-7,9-trans-11,14-cis-eicosatetrenoic acid (leukotriene A4). Leukotrienes
are important mediators of a number of inflammatory and allergic conditions. Mutations in the promoter region of
this gene lead to a diminished response to antileukotriene drugs used in the treatment of asthma and may also be
associated with atherosclerosis and several cancers. Alternatively spliced transcript variants encoding different
isoforms have been found for this gene. (provided by RefSeq, Jan 2012)

GeneCards Summary for ALOX5 Gene: 
ALOX5 (arachidonate 5-lipoxygenase) is a protein-coding gene. Diseases associated with ALOX5 include asthma, diminished response to antileukotriene treatment in, and atherosclerosis, and among its related super-pathways are Arachidonic acid metabolism and aspirin triggered resolvin E biosynthesis. GO annotations related to this gene include arachidonate 5-lipoxygenase activity and iron ion binding. An important paralog of this gene is ALOX12B.

UniProtKB/Swiss-Prot: LOX5_HUMAN, P09917
Function: Catalyzes the first step in leukotriene biosynthesis, and thereby plays a role in inflammatory processes

summary for ALOX5 Gene:
Lipoxygenases (LOXs) are a family of non-heme iron dioxygenases that are involved in the production and
metabolism of fatty acid hydroperoxidases. There are six lipoxygenase isozymes; 5-LOX, 12R-LOX, 12S-LOX,
15-LOX-1 and 15-LOX-2, which catalyze the regio-selective addition of oxygen into arachidonic acid, and
epidermal LOX (E-LOX) which metabolizes 12R-hydroperoxyeicosatetraenoic acid (12R-HPETE) to a specific
epoxyalcohol compound. Different isozymes have different physiological roles; 5-, 12R-, 12S- and 15-LOX-1
have proliferative, antiapoptotic and angiogenic functions whilst 15-LOX-2 has roles in differentiation,
growth arrest and the induction of apoptosis. E-LOX, the most divergent member of this family, is involved
in terminal differentiation of keratinocytes and has a major role in skin barrier function. Perturbations in
lipoxygenase enzymes have been implicated in various human diseases including bronchial asthma,
atherosclerosis, osteoporosis and some cancers.

Gene Wiki entry for ALOX5 (Arachidonate 5-lipoxygenase) Gene

PharmGKB "VIP" summary for ALOX5


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000010.10  NT_033985.7  NC_018921.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ALOX5 gene promoter:
         GR   Sp1   p53   AP-1   ATF-2   Egr-1   GR-alpha   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidALOX5 promoter sequence
   Search SABiosciences Chromatin IP Primers for ALOX5

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ALOX5


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10q11.2   Ensembl cytogenetic band:  10q11.21   HGNC cytogenetic band: 10q11.2

ALOX5 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ALOX5 gene location

GeneLoc information about chromosome 10         GeneLoc Exon Structure

GeneLoc location for GC10P045869:  view genomic region     (about GC identifiers)

Start:
45,869,629 bp from pter      End:
45,941,565 bp from pter
Size:
71,937 bases      Orientation:
plus strand

1 alternative location:
Chr10+,NW_003315935 215,012-286,948     

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: LOX5_HUMAN, P09917 (See protein sequence)
Recommended Name: Arachidonate 5-lipoxygenase  
Size: 674 amino acids; 77983 Da
Cofactor: Binds 1 iron ion per subunit
Cofactor: Binds 2 calcium ions per subunit (By similarity)
Subunit: Interacts with ALOX5AP and LTC4S. Interacts with COTL1, the interaction is required for stability and
efficient catalytic activity
Subcellular location: Cytoplasm. Nucleus matrix. Nucleus membrane; Peripheral membrane protein. Note=Shuttles
between cytoplasm and nucleus. Found exclusively in the nucleus, when phosphorylated on Ser-272. Calcium binding
promotes translocation from the cytosol and the nuclear matrix to the nuclear envelope and membrane association
5 PDB 3D structures from and Proteopedia for ALOX5:
2ABV (3D)        3O8Y (3D)        3V92 (3D)        3V98 (3D)        3V99 (3D)    
Secondary accessions: B7ZLS0 Q5JQ14
Alternative splicing: 2 isoforms:  P09917-1   P09917-2   

Explore the universe of human proteins at neXtProt for ALOX5: NX_P09917

Explore proteomics data for ALOX5 at MOPED 

Post-translational modifications:

  • UniProtKB: Serine phosphorylation by MAPKAPK2 is stimulated by arachidonic acid. Phosphorylation on Ser-523 by PKA has an
    inhibitory effect. Phosphorylation on Ser-272 prevents export from the nucleus
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P09917

  • 4/14 DME Specific Peptides for ALOX5 (P09917) (see all 14)
     WVRSSDF  NPVLIRRC  FGYQFLNG  HAAVNFGQY 

    ALOX5 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    ALOX5 Protein Expression
    REFSEQ proteins (3 alternative transcripts): 
    NP_000689.1  NP_001243082.1  NP_001243083.1  

    ENSEMBL proteins: 
     ENSP00000363512   ENSP00000437634  
    Reactome Protein details: P09917
    Human Recombinant Protein Products for ALOX5: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Enzo Life Sciences proteins for ALOX5
    OriGene Purified Protein for ALOX5
    OriGene Protein Over-expression Lysate for ALOX5
    OriGene MassSpec for ALOX5 
    OriGene Custom Protein Services for ALOX5
    GenScript Custom Purified and Recombinant Proteins Services for ALOX5
    Novus Biologicals ALOX5 Proteins
    Novus Biologicals ALOX5 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for ALOX5 

    Gene Ontology (GO): 5/7 cellular component terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus ----
    GO:0005635nuclear envelope TAS--
    GO:0005641nuclear envelope lumen IDA8245774
    GO:0005737cytoplasm ----
    GO:0005829cytosol TAS--

    ALOX5 for ontologies           About GeneDecksing



    ALOX5 Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of ALOX5
    R&D Systems Antibodies for ALOX5 (5-Lipoxygenase)
    Cell Signaling Technology (CST) Antibodies for ALOX5  (5-LO)
    OriGene Antibodies for ALOX5
    OriGene Custom Antibody Services for ALOX5
    GenScript Custom Superior Antibodies Services for ALOX5
    Novus Biologicals ALOX5 Antibodies
    Abcam antibodies for ALOX5
    Cloud-Clone Corp. Antibodies for ALOX5 
    ThermoFisher Antibody for ALOX5
    LSBio Antibodies in human, mouse, rat for ALOX5 

    Assay Products for ALOX5: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for ALOX5
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for ALOX5
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for ALOX5 
    Cloud-Clone Corp. CLIAs for ALOX5


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    ALOX: Arachidonate lipoxygenases

    IUPHAR Guide to PHARMACOLOGY protein family classification: 5-LOX 
    Lipoxygenases

    5/7 InterPro protein domains (see all 7):
     IPR020833 LipOase_Fe_BS
     IPR013819 LipOase_C
     IPR001024 LipOase_LH2
     IPR008976 Lipase_LipOase
     IPR020834 LipOase_CS

    Graphical View of Domain Structure for InterPro Entry P09917

    ProtoNet protein and cluster: P09917

    3 Blocks protein domains:
    IPB000907 Lipoxygenase
    IPB001024 Lipoxygenase
    IPB001885 Mammalian lipoxygenase signature


    UniProtKB/Swiss-Prot: LOX5_HUMAN, P09917
    Similarity: Belongs to the lipoxygenase family
    Similarity: Contains 1 lipoxygenase domain
    Similarity: Contains 1 PLAT domain


    ALOX5 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: LOX5_HUMAN, P09917
    Function: Catalyzes the first step in leukotriene biosynthesis, and thereby plays a role in inflammatory processes
    Catalytic activity: Arachidonate + O(2) = leukotriene A(4) + H(2)O

         Genatlas biochemistry entry for ALOX5:
    arachidonate-5-lipoxygenase,lipid peroxidating enzyme implicated in the pathogenesis of inflammatory disorders as
    well as membrane remodeling,carcinogenesis,atheroma and asthma formation,involved in leukotriene metabolism

         Enzyme Numbers (IUBMB): EC 1.13.11.341 2 EC 1.13.112

         Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004051arachidonate 5-lipoxygenase activity IDA--
    GO:0005506iron ion binding IDA--
    GO:0005515protein binding IPI11297527
    GO:0016165linoleate 13S-lipoxygenase activity ----
    GO:0016702oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen ----
         
    ALOX5 for ontologies           About GeneDecksing


    Phenotypes:
         7 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Alox5):
     adipose tissue  cardiovascular system  cellular  hematopoietic system  homeostasis/metabolism 
     immune system  skeleton 

    ALOX5 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for ALOX5: Alox5tm1Bhk Alox5tm1Fun

       inGenious Targeting Laboratory - Custom generated mouse model solutions for ALOX5 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for ALOX5

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for ALOX5 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for ALOX5 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ALOX5
    1 QIAGEN miScript miRNA Assays for microRNA that regulate ALOX5:
    hsa-miR-3121-3p
    SwitchGear 3'UTR luciferase reporter plasmidALOX5 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for ALOX5
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ALOX5

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for ALOX5
    Sirion Biotech Customized adenovirus for overexpression of ALOX5

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for ALOX5 (see all 7)
    OriGene ORF clones in mouse, rat for ALOX5
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: ALOX5 (NM_000698)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ALOX5
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ALOX5
    Sirion Biotech Customized lentivirus for stable overexpression of ALOX5 
                         Customized lentivirus expression plasmids for stable overexpression of ALOX5 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for ALOX5
    Search LifeMap BioReagents cell lines for ALOX5
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ALOX5


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for ALOX5 About   (see all 14)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Arachidonic acid metabolism
    Arachidonic acid metabolism0.44
    Synthesis of Leukotrienes (LT) and Eoxins (EX)0.41
    Arachidonic acid metabolism0.44
    HETE and HPETE biosynthesis and metabolism0.35
    2aspirin triggered resolvin E biosynthesis
    aspirin triggered resolvin E biosynthesis0.67
    leukotriene biosynthesis0.33
    aspirin-triggered lipoxin biosynthesis0.67
    Leukotriene modifiers pathway, Pharmacodynamics0.30
    aspirin triggered resolvin D biosynthesis0.67
    3Metabolism
    Metabolism0.40
    Metabolism of lipids and lipoproteins0.34
    Metabolic pathways0.40
    4lipoxin biosynthesis
    lipoxin biosynthesis0.67
    resolvin D biosynthesis0.67
    5Synthesis of 15-eicosatetraenoic acid derivatives
    Synthesis of 5-eicosatetraenoic acids0.33
    Synthesis of Lipoxins (LX)0.33

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 EMD Millipore Pathway for ALOX5
        HETE and HPETE biosynthesis and metabolism

    1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for ALOX5
        all-trans-Retinoic Acid Signaling in Brain

    2 Cell Signaling Technology (CST) Pathways for ALOX5
        Ca, cAMP and Lipid Signaling
    Lymphocyte Signaling

    1 GeneGo (Thomson Reuters) Pathway for ALOX5
        HETE and HPETE biosynthesis and metabolism

    5/9 BioSystems Pathways for ALOX5 (see all 9)
        Eicosanoid Synthesis
    IL-5 Signaling Pathway
    Selenium Pathway
    leukotriene biosynthesis
    aspirin triggered resolvin E biosynthesis

    5/6        Reactome Pathways for ALOX5 (see all 6)
        Synthesis of Lipoxins (LX)
    Metabolism
    Synthesis of Leukotrienes (LT) and Eoxins (EX)
    Arachidonic acid metabolism
    Synthesis of 5-eicosatetraenoic acids

    1 PharmGKB Pathway for ALOX5
        Leukotriene modifiers pathway, Pharmacodynamics

    5         Kegg Pathways  (Kegg details for ALOX5):
        Arachidonic acid metabolism
    Metabolic pathways
    Serotonergic synapse
    Ovarian steroidogenesis
    Toxoplasmosis

    UniProtKB/Swiss-Prot: LOX5_HUMAN, P09917
    Pathway: Lipid metabolism; leukotriene A4 biosynthesis


    ALOX5 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for ALOX5

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/51 Interacting proteins for ALOX5 (P099171, 3 ENSP000003635124) via UniProtKB, MINT, STRING, and/or I2D (see all 51)

    InteractantInteraction Details
    GeneCardExternal ID(s)
    COTL1Q140191, 3, ENSP000002624284EBI-79934,EBI-79926 I2D: score=5 STRING: ENSP00000262428
    TGFBRAP1Q8WUH23, ENSP000002584494I2D: score=4 STRING: ENSP00000258449
    ALOX5APP202923, ENSP000003698584I2D: score=3 STRING: ENSP00000369858
    ACTBP607093, ENSP000003499604I2D: score=2 STRING: ENSP00000349960
    MAPKAPK2P491373, ENSP000003560704I2D: score=2 STRING: ENSP00000356070
    About this table

    Gene Ontology (GO): 5/9 biological process terms (GO ID links to tree view) (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0002540leukotriene production involved in inflammatory response IEA--
    GO:0006691leukotriene metabolic process TAS--
    GO:0006954inflammatory response ----
    GO:0019369arachidonic acid metabolic process TAS--
    GO:0019370leukotriene biosynthetic process IDA--

    ALOX5 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    ALOX5 for compounds           About GeneDecksing

    EMD Millipore small molecules for ALOX5:
    Small Molecule - inhibitor
    Enzo Life Sciences drugs & compounds for ALOX5

    Compounds for ALOX5 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    BAY-X 1005Orally active 5-lipoxygenase activating protein (FLAP) inhibitor[128253-31-6]
    BW-B 70C5-Lipoxygenase inhibitor[134470-38-5]
    ZileutonOrally active 5-LOX inhibitor[111406-87-2]
    MK 886Inhibitor of 5-lipoxygenase-activating protein (FLAP)[118414-82-7]
    Baicalein5- and 12-Lipoxygenase inhibitor[491-67-8]

    10/12 HMDB Compounds for ALOX5 (see all 12)    About this table
    CompoundSynonyms CAS #PubMed Ids
    18R-HEPE18(R)-hydroxyeicosa-5Z,8Z,11E,14Z,16E-pentaenoate (see all 3)----
    5(S)-Hydroperoxyeicosatetraenoic acid5-hydroperoxy-6-trans-8,11,14-cis-eicosatetraenoic acid (see all 6)71774-08-8--
    5-HPETE5(S)-HPETE (see all 7)74581-83-2--
    9(S)-HPODE ----
    Arachidonic acid5,8,11,14-Eicosatetraenoic acid (see all 16)506-32-1--
    Caffeic acid3,4-Dihydroxybenzeneacrylate (see all 9)331-39-5--
    CalciumCa (see all 2)7440-70-2--
    IronArmco iron (see all 19)7439-89-6--
    Leukotriene A4LTA4 (see all 10)72059-45-1--
    Linoleic acid(9Z,12Z)-9,12-Octadecadienoate (see all 26)60-33-3--

    10/14 DrugBank Compounds for ALOX5 (see all 14)    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Zileuton-- 111406-87-2targetinhibitor10694244 11529688 8058773 11561080 17394438 19645854 11752352 10322101 8826571 20436887 10377029
    DiethylcarbamazineCarbamazine (see all 5)90-89-1targetinhibitor3004501 1886988 11752352 1400062 8606397 10518442
    MasoprocolDihydronorguaiaretic acid (see all 7)500-38-9targetinhibitor11277534 15098224 15694390 11752352 15379894 11318430
    Aminosalicylic Acid4-aminosalicylic acid (see all 10)65-49-6targetinhibitor6428914 6131674 2882965
    DiclofenacDiclofenac Acid (see all 4)15307-86-5targetpotentiator15525540 12826271 12932896
    Mesalazine5-aminosalicylate (see all 4)89-57-6targetinhibitor6428914 6131674 2882965
    Minocycline-- 10118-90-8targetinhibitor17506934 16574083 15371729
    SulfasalazineSulfasalazin (see all 2)599-79-1targetinhibitor6428914 6131674 2882965
    BalsalazideBalsalazida [Spanish] (see all 4)80573-04-2targetinhibitor1359745 19743890
    Meclofenamic acidAcide meclofenamique [INN-French] (see all 6)644-62-2targetinhibitor1539679 3020588

    3 IUPHAR Ligands for ALOX5 (5-LOX)    About this table 
    LigandTypeActionAffinityPubmed IDs
    zileuton
    InhibitorInhibition--
    5-LOX activating protein
    ActivatorActivation--
    CJ13610
    InhibitorInhibition15197110

    10/144 Novoseek inferred chemical compound relationships for ALOX5 gene (see all 144)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    leukotriene b4 95.7 449 14530386 (6), 1330161 (5), 1314503 (4), 9142859 (4) (see all 99)
    zileuton 95.7 160 11561080 (4), 8826571 (3), 7551371 (3), 8620667 (2) (see all 99)
    arachidonic acid 94 889 16275640 (8), 8049076 (6), 7577949 (4), 11867685 (4) (see all 99)
    5-hydroxyeicosatetraenoic acid 92.8 60 8358023 (3), 9789062 (3), 1328141 (1), 8223906 (1) (see all 32)
    mk 886 91.1 50 2104841 (4), 8917356 (2), 19862483 (2), 15779087 (2) (see all 36)
    aa861 89.7 38 8223906 (2), 1330136 (2), 7766427 (1), 8596775 (1) (see all 27)
    ltc4 88.8 84 7900879 (3), 10102384 (3), 9296112 (2), 9431445 (2) (see all 50)
    5-hpete 88.5 37 8395245 (4), 7811715 (3), 8164257 (2), 1848236 (2) (see all 18)
    licofelone 88.3 45 17704828 (10), 18268076 (2), 11550975 (2), 15498796 (2) (see all 13)
    lte4 86.5 29 19336727 (3), 15519606 (2), 2153812 (1), 9596112 (1) (see all 18)

    1 PharmGKB related drug/compound annotation for ALOX5 gene    About this table
    Drug/compound PharmGKB Annotation
    montelukastCA  

    Search CenterWatch for drugs/clinical trials and news about ALOX5 / LOX5

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for ALOX5 gene (3 alternative transcripts): 
    NM_000698.3  NM_001256153.1  NM_001256154.1  

    Unigene Cluster for ALOX5:

    Arachidonate 5-lipoxygenase
    Hs.89499  [show with all ESTs]
    Unigene Representative Sequence: NM_000698
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000374391(uc001jce.3 uc009xmt.3 uc010qfg.2 uc021ppr.1)
    ENST00000483623 ENST00000475300 ENST00000493336 ENST00000481117 ENST00000498461
    ENST00000542434

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    Additional mRNA sequence: 

    AK225603.1 AK315223.1 BC034464.1 BC040450.1 BC130332.1 BC132677.1 BC143985.1 BC143986.1 
    J03571.1 J03600.1 JQ728550.1 

    8 DOTS entries:

    DT.449694  DT.92427412  DT.95193567  DT.97806426  DT.100771760  DT.210270  DT.86839247  DT.95142328 

    24/177 AceView cDNA sequences (see all 177):

    AI799008 BQ786870 BI837266 AA315865 AA505143 BI822076 AA587201 AI698814 
    BX386145 AI075284 AA767516 BQ787144 AI380545 AA926891 BC040450 BE710304 
    CA439600 BX377162 BX346381 BE676451 BC034464 AI798007 BM726803 CA390028 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ALOX5 expression in normal human tissues (normalized intensities)      ALOX5 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GGATGATTAT
    ALOX5 Expression
    About this image


    ALOX5 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/30 selected tissues (see all 30) fully expand
     
     Blood (Hematopoietic System)    fully expand to see all 10 entries
             Umbilical cord blood-derived hematopoietic stem cells
             Fetal Liver CD36+ Cells   
             monocytes   
     
     Uterus
             uterus, post-menopause ; glandular cells   
     
     Epithelium
             vagina ; squamous epithelial cells   
     
     Lymph (Hematopoietic System)    fully expand to see all 4 entries
             lymph node ; non-germinal center cells   
             LYMPH NODE   
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex

    See ALOX5 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ALOX5

    SOURCE GeneReport for Unigene cluster: Hs.89499
        SABiosciences Expression via Pathway-Focused PCR Arrays including ALOX5 (see all 6): 
              Hypertension in human mouse rat
              Endothelial Cell Biology in human mouse rat
              Leukemia in human mouse rat
              Insulin Resistance in human mouse rat
              Drug Metabolism in human mouse rat

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for ALOX5 gene from 6/14 species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Alox51 , 5 arachidonate 5-lipoxygenase1, 5 87.88(n)1
    93.47(a)1
      6 (53.79 cM)5
    116891  NM_009662.21  NP_033792.11 
     1164100775 
    chicken
    (Gallus gallus)
    Aves ALOX51 arachidonate 5-lipoxygenase 76.85(n)
    83.68(a)
      423769  XM_003641512.1  XP_003641560.1 
    lizard
    (Anolis carolinensis)
    Reptilia ALOX56
    arachidonate 5-lipoxygenase
    80(a)
    1 ↔ 1
    4(74247872-74284175)
    zebrafish
    (Danio rerio)
    Actinopterygii alox51 arachidonate 5-lipoxygenase 70.08(n)
    74.48(a)
      567204  XM_690495.3  XP_695587.2 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons LOX51 lipoxygenase 5 44.09(n)
    33.47(a)
      821808  NM_113137.3  NP_188879.2 
    rice
    (Oryza sativa)
    Liliopsida Os03g07386001 hypothetical protein 49.85(n)
    33.48(a)
      4334049  NM_001057747.1  NP_001051212.1 


    ENSEMBL Gene Tree for ALOX5 (if available)
    TreeFam Gene Tree for ALOX5 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ALOX5 gene
    ALOX12B2  ALOX15B2  ALOXE32  ALOX152  ALOX122  
    6 SIMAP similar genes for ALOX5 using alignment to 5 protein entries:     LOX5_HUMAN (see all proteins):
    arachidonate 12-lipoxygenase    ALOX15B    ALOX15    ALOX12    ALOX12B    ALOXE3

    ALOX5 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1700 SNPs in ALOX5 are shown (see all 1700)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 10 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1463625601,2
    C,Funtested146051789(+) ATCCCG/AGGAGA 6 /P syn11Minor allele frequency- A:0.00NA 4550
    rs114638101,2
    C--42426839(+) CTACC-/T/TT  
            
    TTTTT
    3 -- int10--------
    rs710231091,2
    C--42452652(+) TATTT-/ATTT  
            
    ATTTA
    3 -- int11Minor allele frequency- ATTT:0.00NA 2
    rs112907501,2
    C,F--42459227(+) TCCTCT/-TTTTT 3 -- int1 trp32Minor allele frequency- -:0.50NA CSA 4
    rs715153461,2
    C--45868357(+) TGGAC-/TTAAAG
            
    TTAAA
    6 -- us2k1 cds12Minor allele frequency- TTAAAG:0.25NA CSA 4
    rs1126152521,2
    C--45883775(+) TGACAG/-GCTTT 6 -- int11Minor allele frequency- -:0.50CSA 2
    rs1411400521,2
    C--45886452(+) TCTCC-/CC    
       TCTCT
    CCTCT
    6 -- int10--------
    rs2000953141,2
    C--45886458(+) CTCTCC/TCCTCT 6 -- int10--------
    rs557893361,2
    C--45887115(+) GGCCGC/TCCATC 3 -- int10--------
    rs558372121,2
    C--45887118(+) CGCCCA/GTCGTC 3 -- int10--------

    HapMap Linkage Disequilibrium report for ALOX5 (45869629 - 45941565 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 7 variations for ALOX5:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2567160CNV Deletion19546169
    esv2513283CNV Deletion19546169
    nsv895110CNV Loss21882294
    nsv895107CNV Loss21882294
    nsv466910CNV Loss19166990
    nsv895105CNV Gain21882294
    dgv651n71CNV Gain21882294


    Human Gene Mutation Database (HGMD): ALOX5
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 152390   
    OMIM disorders: 600807  
    20/125 diseases for ALOX5 (see all 125):    About MalaCards
    asthma, diminished response to antileukotriene treatment in    atherosclerosis    sjogren-larsson syndrome    asthma
    urticaria    glutathione synthetase deficiency    tuberculous meningitis    arthus reaction
    panniculitis    pancreatic ductal carcinoma    pleurisy    primary pulmonary hypertension
    adult respiratory distress syndrome    churg-strauss syndrome    benign meningioma    pulmonary fibrosis
    angioedema    colonic polyps    rhinitis    klebsiella

    5 diseases from the University of Copenhagen DISEASES database for ALOX5:
    Asthma     Atherosclerosis     Arthritis     Pleurisy
    Cancer

    ALOX5 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    The International Symposium on Pneumococci and Pneumococcal Diseases (ISPPD) 9 - 13 March 2014
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    10/94 Novoseek inferred disease relationships for ALOX5 gene (see all 94)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    asthma 72.7 180 8473681 (4), 8129222 (4), 16364163 (4), 8598621 (4) (see all 98)
    inflammation 68.1 116 16250846 (3), 1309754 (2), 12733982 (2), 17305572 (2) (see all 90)
    leukemia basophilic 60.2 16 8071328 (2), 12005204 (1), 8140120 (1), 19243697 (1) (see all 12)
    asthma exercise-induced 59.4 5 8630575 (2), 16027142 (1), 10984370 (1), 17481554 (1)
    ear edema 59.3 4 1665293 (2), 7916384 (1), 9599246 (1)
    allergic rhinitis 50.8 7 12607939 (1), 9809497 (1), 9444606 (1), 1701029 (1) (see all 6)
    atherosclerosis 47 50 17481551 (2), 14702425 (2), 18842779 (2), 17825794 (2) (see all 31)
    anaphylaxis 46.7 9 8081074 (3), 1949224 (1), 8480540 (1), 9532969 (1) (see all 6)
    asthma allergic 45.2 7 8994519 (1), 9444606 (1), 1851340 (1), 17481554 (1) (see all 6)
    edema 44.7 20 7541689 (2), 1478686 (2), 8032607 (2), 9444606 (1) (see all 12)

    Genetic Association Database (GAD): ALOX5
    Human Genome Epidemiology (HuGE) Navigator: ALOX5 (78 documents)

    Export disorders for ALOX5 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ALOX5 gene, integrated from 9 sources (see all 1374):
    (articles sorted by number of sources associating them with ALOX5)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Arachidonate lipoxygenase (ALOX) and cyclooxygenase (COX) polymorphisms and colon cancer risk. (PubMed id 15308583)1, 2, 4 Goodman J.E.... Harris C.C. (2004)
    2. Characterization of the human 5-lipoxygenase gene. (PubMed id 2565035)1, 2, 3 Funk C.D.... Samuelsson B. (1989)
    3. Protein kinase A inhibits leukotriene synthesis by phosphorylation of 5-lipoxygenase on serine 523. (PubMed id 15280375)1, 2, 9 Luo M....Brock T.G. (2004)
    4. Coactosin-like protein functions as a stabilizing cha perone for 5-lipoxygenase: role of tryptophan 102. (PubMed id 19807693)1, 2, 9 Esser J....RAYdmark O. (2010)
    5. Phosphorylation of serine 271 on 5-lipoxygenase and its role in nuclear export. (PubMed id 18978352)1, 2, 9 Flamand N.... Brock T.G. (2009)
    6. Arachidonic acid regulates the translocation of 5-lipoxygenase to the nuclear membranes in human neutrophils. (PubMed id 16275640)1, 2, 9 Flamand N....Borgeat P. (2006)
    7. Arachidonic acid promotes phosphorylation of 5-lipoxygenase at Ser- 271 by MAPK-activated protein kinase 2 (MK2). (PubMed id 11844797)1, 2, 9 Werz O.... Radmark O. (2002)
    8. ALOX5 promoter genotype, asthma severity and LTC production by eosinophils. (PubMed id 16364163)1, 4, 9 Kalayci O....Lilly C. (2006)
    9. 5-lipoxygenase and 5-lipoxygenase-activating protein are localized in the nuclear envelope of activated human leukocytes. (PubMed id 8245774)1, 2, 9 Woods J.W....Singer I.I. (1993)
    10. Evaluation of the role of conserved His and Met residues among lipoxygenases by site-directed mutagenesis of recombinant human 5- lipoxygenase. (PubMed id 1939225)1, 2, 9 Nguyen T.... Riendeau D. (1991)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 240 HGNC: 435 AceView: ALOX5 Ensembl:ENSG00000012779 euGenes: HUgn240
    ECgene: ALOX5 Kegg: 240 H-InvDB: ALOX5

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ALOX5 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for ALOX5 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for ALOX5 gene:
    Search GeneIP for patents involving ALOX5

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

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