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ALOX5 Gene

protein-coding   GIFtS: 69
GCID: GC10P045869

Arachidonate 5-Lipoxygenase

  See ALOX5-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Arachidonate 5-Lipoxygenase1 2     Arachidonic 5-Lipoxygenase Delta-10-13 Isoform2
5-LO2 3     Arachidonic 5-Lipoxygenase Delta-13 Isoform2
LOG52 3     Arachidonic 5-Lipoxygenase Delta-P10 Isoform2
EC 1.13.11.343 8     Arachidonic Acid 5-Lipoxygenase2
5-LOX2     Leukotriene A4 Synthase2
5LPG2     5-lipoxygenase3
LOX-52     EC 1.13.118
Arachidonic 5-Lipoxygenase Alpha-10 Isoform2     

External Ids:    HGNC: 4351   Entrez Gene: 2402   Ensembl: ENSG000000127797   OMIM: 1523905   UniProtKB: P099173   

Export aliases for ALOX5 gene to outside databases

Previous GC identifers: GC10P045171 GC10P045338 GC10P045644 GC10P045153 GC10P045189 GC10P042394


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for ALOX5 Gene:
This gene encodes a member of the lipoxygenase gene family and plays a dual role in the synthesis of leukotrienes
from arachidonic acid. The encoded protein, which is expressed specifically in bone marrow-derived cells,
catalyzes the conversion of arachidonic acid to 5(S)-hydroperoxy-6-trans-8,11,14-cis-eicosatetraenoic acid, and
further to the allylic epoxide 5(S)-trans-7,9-trans-11,14-cis-eicosatetrenoic acid (leukotriene A4). Leukotrienes
are important mediators of a number of inflammatory and allergic conditions. Mutations in the promoter region of
this gene lead to a diminished response to antileukotriene drugs used in the treatment of asthma and may also be
associated with atherosclerosis and several cancers. Alternatively spliced transcript variants encoding different
isoforms have been found for this gene. (provided by RefSeq, Jan 2012)

GeneCards Summary for ALOX5 Gene:
ALOX5 (arachidonate 5-lipoxygenase) is a protein-coding gene. Diseases associated with ALOX5 include asthma, diminished response to antileukotriene treatment in, and atherosclerosis. GO annotations related to this gene include arachidonate 5-lipoxygenase activity and iron ion binding. An important paralog of this gene is ALOX12B.

UniProtKB/Swiss-Prot: LOX5_HUMAN, P09917
Function: Catalyzes the first step in leukotriene biosynthesis, and thereby plays a role in inflammatory processes

summary for ALOX5 Gene:
Lipoxygenases (LOXs) are a family of non-heme iron dioxygenases that are involved in the production and
metabolism of fatty acid hydroperoxidases. There are six lipoxygenase isozymes; 5-LOX, 12R-LOX, 12S-LOX,
15-LOX-1 and 15-LOX-2, which catalyze the regio-selective addition of oxygen into arachidonic acid, and
epidermal LOX (E-LOX) which metabolizes 12R-hydroperoxyeicosatetraenoic acid (12R-HPETE) to a specific
epoxyalcohol compound. Different isozymes have different physiological roles; 5-, 12R-, 12S- and 15-LOX-1
have proliferative, antiapoptotic and angiogenic functions whilst 15-LOX-2 has roles in differentiation,
growth arrest and the induction of apoptosis. E-LOX, the most divergent member of this family, is involved
in terminal differentiation of keratinocytes and has a major role in skin barrier function. Perturbations in
lipoxygenase enzymes have been implicated in various human diseases including bronchial asthma,
atherosclerosis, osteoporosis and some cancers.

Gene Wiki entry for ALOX5 (Arachidonate 5-lipoxygenase) Gene

PharmGKB "VIP" summary for ALOX5


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000010.10  NC_018921.2  NT_030059.14  
Regulatory elements:
   Regulatory transcription factor binding sites in the ALOX5 gene promoter:
         GR   Sp1   p53   AP-1   ATF-2   Egr-1   GR-alpha   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidALOX5 promoter sequence
   Search Chromatin IP Primers for ALOX5

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ALOX5


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10q11.2   Ensembl cytogenetic band:  10q11.21   HGNC cytogenetic band: 10q11.2

ALOX5 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ALOX5 gene location

GeneLoc information about chromosome 10         GeneLoc Exon Structure

GeneLoc location for GC10P045869:  view genomic region     (about GC identifiers)

Start:
45,869,629 bp from pter      End:
45,941,565 bp from pter
Size:
71,937 bases      Orientation:
plus strand

1 alternative location:
Chr10+,NW_003315935 215,012-286,948     

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: LOX5_HUMAN, P09917 (See protein sequence)
Recommended Name: Arachidonate 5-lipoxygenase  
Size: 674 amino acids; 77983 Da
Cofactor: Binds 1 iron ion per subunit
Cofactor: Binds 2 calcium ions per subunit (By similarity)
Subunit: Interacts with ALOX5AP and LTC4S. Interacts with COTL1, the interaction is required for stability and
efficient catalytic activity
5 PDB 3D structures from and Proteopedia for ALOX5:
2ABV (3D)        3O8Y (3D)        3V92 (3D)        3V98 (3D)        3V99 (3D)    
Secondary accessions: B7ZLS0 E5FPY5 E5FPY7 E5FPY8 Q5JQ14
Alternative splicing: 5 isoforms:  P09917-1   P09917-2   P09917-3   P09917-4   P09917-5   

Explore the universe of human proteins at neXtProt for ALOX5: NX_P09917

Explore proteomics data for ALOX5 at MOPED

Post-translational modifications: 

  • Serine phosphorylation by MAPKAPK2 is stimulated by arachidonic acid. Phosphorylation on Ser-523 by PKA has an
    inhibitory effect. Phosphorylation on Ser-272 prevents export from the nucleus1
  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for ALOX5 (P09917) (see all 14)
     WVRSSDF  NPVLIRRC  FGYQFLNG  HAAVNFGQY 


    See ALOX5 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_000689.1  NP_001243082.1  NP_001243083.1  

    ENSEMBL proteins: 
     ENSP00000363512   ENSP00000437634  
    Reactome Protein details: P09917

    ALOX5 Human Recombinant Protein Products:

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    OriGene MassSpec for ALOX5
    OriGene Custom Protein Services for ALOX5
    GenScript Custom Purified and Recombinant Proteins Services for ALOX5
    Novus Biologicals ALOX5 Proteins
    Novus Biologicals ALOX5 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for ALOX5

     
    Search eBioscience for Proteins for ALOX5 

     
    antibodies-online proteins for ALOX5 (16 products) 

     
    antibodies-online peptides for ALOX5

    ALOX5 Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of ALOX5
    R&D Systems Antibodies for ALOX5 (5-Lipoxygenase)
    Cell Signaling Technology (CST) Antibodies for ALOX5  (5-LO)
    OriGene Antibodies for ALOX5
    OriGene Custom Antibody Services for ALOX5
    Novus Biologicals ALOX5 Antibodies
    Abcam antibodies for ALOX5
    Cloud-Clone Corp. Antibodies for ALOX5
    ThermoFisher Antibody for ALOX5
    antibodies-online antibodies for ALOX5 (119 products) 

    ALOX5 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for ALOX5
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for ALOX5
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for ALOX5
    Cloud-Clone Corp. CLIAs for ALOX5
    Search eBioscience for ELISAs for ALOX5 
    antibodies-online kits for ALOX5 (45 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ALOX: Arachidonate lipoxygenases

    IUPHAR Guide to PHARMACOLOGY protein family classification: 5-LOX
    Lipoxygenases

    Selected InterPro protein domains (see all 7):
     IPR020833 LipOase_Fe_BS
     IPR013819 LipOase_C
     IPR001024 PLAT/LH2_dom
     IPR008976 Lipase_LipOase
     IPR020834 LipOase_CS

    Graphical View of Domain Structure for InterPro Entry P09917

    ProtoNet protein and cluster: P09917

    3 Blocks protein domains:
    IPB000907 Lipoxygenase
    IPB001024 Lipoxygenase
    IPB001885 Mammalian lipoxygenase signature


    UniProtKB/Swiss-Prot: LOX5_HUMAN, P09917
    Similarity: Belongs to the lipoxygenase family
    Similarity: Contains 1 lipoxygenase domain
    Similarity: Contains 1 PLAT domain


    Find genes that share domains with ALOX5           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: LOX5_HUMAN, P09917
    Function: Catalyzes the first step in leukotriene biosynthesis, and thereby plays a role in inflammatory processes
    Catalytic activity: Arachidonate + O(2) = leukotriene A(4) + H(2)O

         Genatlas biochemistry entry for ALOX5:
    arachidonate-5-lipoxygenase,lipid peroxidating enzyme implicated in the pathogenesis of inflammatory disorders as
    well as membrane remodeling,carcinogenesis,atheroma and asthma formation,involved in leukotriene metabolism

         Enzyme Numbers (IUBMB): EC 1.13.11.341 2 EC 1.13.112

         Gene Ontology (GO): 5 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004051arachidonate 5-lipoxygenase activity IDA--
    GO:0005506iron ion binding IDA--
    GO:0005515protein binding IPI11297527
    GO:0016702oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen ----
    GO:0046872metal ion binding ----
         
    Find genes that share ontologies with ALOX5           About GenesLikeMe


    Phenotypes:
         7 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Alox5):
     adipose tissue  cardiovascular system  cellular  hematopoietic system  homeostasis/metabolism 
     immune system  skeleton 

    Find genes that share phenotypes with ALOX5           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for ALOX5: Alox5tm1Bhk Alox5tm1Fun

       genOway: Develop your customized and physiologically relevant rodent model for ALOX5

    miRNA
    Products:
        
    Block miRNA regulation of human, mouse, rat ALOX5 using miScript Target Protectors
    1 qRT-PCR Assays for microRNA that regulate ALOX5:
    hsa-miR-3121-3p
    SwitchGear 3'UTR luciferase reporter plasmidALOX5 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for ALOX5
    Predesigned siRNA for gene silencing in human, mouse, rat ALOX5

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for ALOX5

    Clone
    Products:
         
    OriGene clones in human, mouse for ALOX5 (see all 6)
    OriGene ORF clones in mouse, rat for ALOX5
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: ALOX5 (NM_000698)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ALOX5
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ALOX5

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for ALOX5
    Browse ESI BIO Cell Lines and PureStem Progenitors for ALOX5 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ALOX5


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    LOX5_HUMAN, P09917: Cytoplasm. Nucleus matrix. Nucleus membrane; Peripheral membrane protein. Note=Shuttles
    between cytoplasm and nucleus. Found exclusively in the nucleus, when phosphorylated on Ser-272. Calcium binding
    promotes translocation from the cytosol and the nuclear matrix to the nuclear envelope and membrane association
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol5
    nucleus5
    extracellular2
    cytoskeleton1
    mitochondrion1
    peroxisome1
    plasma membrane1

    Gene Ontology (GO): Selected cellular component terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005615extracellular space IDA--
    GO:0005634nucleus ----
    GO:0005635nuclear envelope TAS--
    GO:0005641nuclear envelope lumen IDA8245774
    GO:0005737cytoplasm ----

    Find genes that share ontologies with ALOX5           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for ALOX5 About   (see all 13)  
    See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1Arachidonic acid metabolism
    Arachidonic acid metabolism0.41
    resolvin D biosynthesis0.00
    Arachidonic acid metabolism0.40
    lipoxin biosynthesis0.00
    HETE and HPETE biosynthesis and metabolism0.33
    Synthesis of 5-eicosatetraenoic acids0.00
    Synthesis of Leukotrienes (LT) and Eoxins (EX)0.00
    Synthesis of Lipoxins (LX)0.00
    2Metabolism
    Metabolism0.38
    Metabolism of lipids and lipoproteins0.37
    Metabolic pathways0.38
    3Eicosanoid Synthesis
    Eicosanoid Synthesis
    aspirin triggered resolvin E biosynthesis0.00
    4aspirin triggered resolvin D biosynthesis
    aspirin triggered resolvin D biosynthesis
    aspirin-triggered lipoxin biosynthesis0.00
    5PEDF Induced Signaling
    all-trans-Retinoic Acid Signaling in Brain0.71


    Find genes that share SuperPaths with ALOX5           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 Downloadable PowerPoint Slide of GeneGlobe Pathway Central Maps for ALOX5
        all-trans-Retinoic Acid Signaling in Brain

    2 Cell Signaling Technology (CST) Pathways for ALOX5
        Ca, cAMP and Lipid Signaling
    Lymphocyte Signaling

    1 GeneGo (Thomson Reuters) Pathway for ALOX5
        HETE and HPETE biosynthesis and metabolism

    Selected BioSystems Pathways for ALOX5 (see all 9)
        Eicosanoid Synthesis
    IL-5 Signaling Pathway
    Selenium Pathway
    leukotriene biosynthesis
    aspirin triggered resolvin E biosynthesis

    3 Reactome Pathways for ALOX5
        Synthesis of Lipoxins (LX)
    Synthesis of Leukotrienes (LT) and Eoxins (EX)
    Synthesis of 5-eicosatetraenoic acids

    1 PharmGKB Pathway for ALOX5
        Leukotriene modifiers pathway, Pharmacodynamics

    5 Kegg Pathways  (Kegg details for ALOX5):
        Arachidonic acid metabolism
    Metabolic pathways
    Serotonergic synapse
    Ovarian steroidogenesis
    Toxoplasmosis

    UniProtKB/Swiss-Prot: LOX5_HUMAN, P09917
    Pathway: Lipid metabolism; leukotriene A4 biosynthesis

        Pathway & Disease-focused RT2 Profiler PCR Arrays including ALOX5 (see all 6): 

              Hypertension in human mouse rat
              Endothelial Cell Biology in human mouse rat
              Leukemia in human mouse rat
              Insulin Resistance in human mouse rat
              Drug Metabolism in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for ALOX5

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for ALOX5 (P099171, 3 ENSP000003635124) via UniProtKB, MINT, STRING, and/or I2D (see all 51)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    COTL1Q140191, 3, ENSP000002624284EBI-79934,EBI-79926 I2D: score=5 STRING: ENSP00000262428
    TGFBRAP1Q8WUH23, ENSP000002584494I2D: score=4 STRING: ENSP00000258449
    ALOX5APP202923, ENSP000003698584I2D: score=3 STRING: ENSP00000369858
    ACTBP607093, ENSP000003499604I2D: score=2 STRING: ENSP00000349960
    MAPKAPK2P491373, ENSP000003560704I2D: score=2 STRING: ENSP00000356070
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0002540leukotriene production involved in inflammatory response IEA--
    GO:0006691leukotriene metabolic process TAS--
    GO:0006954inflammatory response ----
    GO:0019369arachidonic acid metabolic process TAS--
    GO:0019370leukotriene biosynthetic process IDA--

    Find genes that share ontologies with ALOX5           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Enzo Life Sciences drugs & compounds for ALOX5
      Browse compounds at ApexBio 

    Compounds for ALOX5 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    BAY-X 1005Orally active 5-lipoxygenase activating protein (FLAP) inhibitor[128253-31-6]
    BW-B 70C5-Lipoxygenase inhibitor[134470-38-5]
    ZileutonOrally active 5-LOX inhibitor[111406-87-2]
    MK 886Inhibitor of 5-lipoxygenase-activating protein (FLAP)[118414-82-7]
    Baicalein5- and 12-Lipoxygenase inhibitor[491-67-8]

    Selected HMDB Compounds for ALOX5 (see all 12)    About this table
    CompoundSynonyms CAS #PubMed Ids
    18R-HEPE18(R)-hydroxyeicosa-5Z,8Z,11E,14Z,16E-pentaenoate (see all 3)----
    5(S)-Hydroperoxyeicosatetraenoic acid5-hydroperoxy-6-trans-8,11,14-cis-eicosatetraenoic acid (see all 6)71774-08-8--
    5-HPETE5(S)-HPETE (see all 7)74581-83-2--
    9(S)-HPODE ----
    Arachidonic acid5,8,11,14-Eicosatetraenoic acid (see all 16)506-32-1--
    Caffeic acid3,4-Dihydroxybenzeneacrylate (see all 9)331-39-5--
    CalciumCa (see all 2)7440-70-2--
    IronArmco iron (see all 19)7439-89-6--
    Leukotriene A4LTA4 (see all 10)72059-45-1--
    Linoleic acid(9Z,12Z)-9,12-Octadecadienoate (see all 26)60-33-3--

    Selected DrugBank Compounds for ALOX5 (see all 14)    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Zileuton-- 111406-87-2targetinhibitor10694244 11529688 8058773 11561080 17394438 19645854 11752352 10322101 8826571 20436887 10377029
    DiethylcarbamazineCarbamazine (see all 5)90-89-1targetinhibitor3004501 1886988 11752352 1400062 8606397 10518442
    MasoprocolDihydronorguaiaretic acid (see all 7)500-38-9targetinhibitor11277534 15098224 15694390 11752352 15379894 11318430
    Aminosalicylic Acid4-aminosalicylic acid (see all 10)65-49-6targetinhibitor6428914 6131674 2882965
    DiclofenacDiclofenac Acid (see all 4)15307-86-5targetpotentiator15525540 12826271 12932896
    Mesalazine5-aminosalicylate (see all 4)89-57-6targetinhibitor6428914 6131674 2882965
    Minocycline-- 10118-90-8targetinhibitor17506934 16574083 15371729
    SulfasalazineSulfasalazin (see all 2)599-79-1targetinhibitor6428914 6131674 2882965
    BalsalazideBalsalazida [Spanish] (see all 4)80573-04-2targetinhibitor1359745 19743890
    Meclofenamic acidAcide meclofenamique [INN-French] (see all 6)644-62-2targetinhibitor1539679 3020588

    3 IUPHAR Ligands for ALOX5 (5-LOX)    About this table
    LigandTypeActionAffinityPubmed IDs
    zileuton
    InhibitorInhibition--
    5-LOX activating protein
    ActivatorActivation--
    CJ13610
    InhibitorInhibition15197110

    Selected Novoseek inferred chemical compound relationships for ALOX5 gene (see all 144)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    leukotriene b4 95.7 449 14530386 (6), 1330161 (5), 1314503 (4), 9142859 (4) (see all 99)
    zileuton 95.7 160 11561080 (4), 8826571 (3), 7551371 (3), 8620667 (2) (see all 99)
    arachidonic acid 94 889 16275640 (8), 8049076 (6), 7577949 (4), 11867685 (4) (see all 99)
    5-hydroxyeicosatetraenoic acid 92.8 60 8358023 (3), 9789062 (3), 1328141 (1), 8223906 (1) (see all 32)
    mk 886 91.1 50 2104841 (4), 8917356 (2), 19862483 (2), 15779087 (2) (see all 36)
    aa861 89.7 38 8223906 (2), 1330136 (2), 7766427 (1), 8596775 (1) (see all 27)
    ltc4 88.8 84 7900879 (3), 10102384 (3), 9296112 (2), 9431445 (2) (see all 50)
    5-hpete 88.5 37 8395245 (4), 7811715 (3), 8164257 (2), 1848236 (2) (see all 18)
    licofelone 88.3 45 17704828 (10), 18268076 (2), 11550975 (2), 15498796 (2) (see all 13)
    lte4 86.5 29 19336727 (3), 15519606 (2), 2153812 (1), 9596112 (1) (see all 18)

    1 PharmGKB related drug/compound annotation for ALOX5 gene    About this table
    Drug/compound PharmGKB Annotation
    montelukastCA  



    Find genes that share compounds with ALOX5           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for ALOX5 gene (3 alternative transcripts): 
    NM_000698.3  NM_001256153.1  NM_001256154.1  

    Unigene Cluster for ALOX5:

    Arachidonate 5-lipoxygenase
    Hs.89499  [show with all ESTs]
    Unigene Representative Sequence: NM_000698
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000374391(uc001jce.3 uc009xmt.3 uc010qfg.2 uc021ppr.1)
    ENST00000483623 ENST00000475300 ENST00000493336 ENST00000481117 ENST00000498461
    ENST00000542434
    miRNA
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    Additional mRNA sequence: 

    AK225603.1 AK315223.1 BC034464.1 BC040450.1 BC130332.1 BC132677.1 BC143985.1 BC143986.1 
    J03571.1 J03600.1 JQ728550.1 

    8 DOTS entries:

    DT.449694  DT.92427412  DT.95193567  DT.97806426  DT.100771760  DT.210270  DT.86839247  DT.95142328 

    Selected AceView cDNA sequences (see all 177):

    CA439600 AA587201 AI380545 AA767516 BX386145 BE710304 BI837266 AI698814 
    BM726803 BC034464 BI822076 AI798007 BQ786870 AA505143 AA315865 AI075284 
    BC040450 BE676451 AA926891 AI799008 CA390028 BX346381 BX377162 BQ787144 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ALOX5 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GGATGATTAT
    ALOX5 Expression
    About this image


    ALOX5 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 10) fully expand
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
     
     Ovary (Reproductive System)    fully expand to see all 3 entries
             Ovarian Mesenchymal Stroma Cells Ovary Interstitium
             Oviduct
     
     Bone (Muscoskeletal System)
             Bone Marrow
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
     
     Testis (Reproductive System)
             Leydig Cells Testis Interstitium
    ALOX5 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ALOX5 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.89499
        Pathway & Disease-focused RT2 Profiler PCR Arrays including ALOX5 (see all 6): 
              Hypertension in human mouse rat
              Endothelial Cell Biology in human mouse rat
              Leukemia in human mouse rat
              Insulin Resistance in human mouse rat
              Drug Metabolism in human mouse rat

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for ALOX5 gene from Selected species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Alox51 , 5 arachidonate 5-lipoxygenase1, 5 87.88(n)1
    93.47(a)1
      6 (53.79 cM)5
    116891  NM_009662.21  NP_033792.11 
     1164100775 
    chicken
    (Gallus gallus)
    Aves ALOX51 arachidonate 5-lipoxygenase 76.85(n)
    83.68(a)
      423769  XM_003641512.2  XP_003641560.1 
    lizard
    (Anolis carolinensis)
    Reptilia ALOX56
    arachidonate 5-lipoxygenase
    80(a)
    1 ↔ 1
    4(74247872-74284175)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia alox51 arachidonate 5-lipoxygenase 71.07(n)
    78.19(a)
      100036609  XM_004915925.1  XP_004915982.1 
    zebrafish
    (Danio rerio)
    Actinopterygii alox5a1 arachidonate 5-lipoxygenase a 70.18(n)
    74.63(a)
      567204  NM_001256747.1  NP_001243676.1 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons LOX51 LOX5 44.58(n)
    33.73(a)
      821808  NM_113137.3  NP_188879.2 
    rice
    (Oryza sativa)
    Liliopsida Os03g06997001 Os03g0699700 46.5(n)
    34.31(a)
      4333818  NM_001057525.1  NP_001050990.1 


    ENSEMBL Gene Tree for ALOX5 (if available)
    TreeFam Gene Tree for ALOX5 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for ALOX5 gene
    ALOX12B2  ALOX15B2  ALOXE32  ALOX152  ALOX122  
    5 SIMAP similar genes for ALOX5 using alignment to 2 protein entries:     LOX5_HUMAN (see all proteins):
    ALOX15B    ALOX12B    ALOX15    ALOX12    ALOXE3

    Find genes that share paralogs with ALOX5           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ALOX5 (see all 1700)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 10 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1463625601,2
    C,Funtested146051789(+) ATCCCG/AGGAGA 6 /P syn11Minor allele frequency- A:0.00NA 4550
    rs114638101,2
    C--42426839(+) CTACC-/T/TT  
            
    TTTTT
    3 -- int10--------
    rs710231091,2
    C--42452652(+) TATTT-/ATTT  
            
    ATTTA
    3 -- int11Minor allele frequency- ATTT:0.00NA 2
    rs112907501,2
    C,F--42459227(+) TCCTCT/-TTTTT 3 -- int1 trp32Minor allele frequency- -:0.50NA CSA 4
    rs715153461,2
    C--45868357(+) TGGAC-/TTAAAG
            
    TTAAA
    6 -- us2k1 cds12Minor allele frequency- TTAAAG:0.25NA CSA 4
    rs1126152521,2
    C--45883775(+) TGACAG/-GCTTT 6 -- int11Minor allele frequency- -:0.50CSA 2
    rs1411400521,2
    C--45886452(+) TCTCC-/CC    
       TCTCT
    CCTCT
    6 -- int10--------
    rs2000953141,2
    C--45886458(+) CTCTCC/TCCTCT 6 -- int10--------
    rs557893361,2
    C--45887115(+) GGCCGC/TCCATC 3 -- int10--------
    rs558372121,2
    C--45887118(+) CGCCCA/GTCGTC 3 -- int10--------

    HapMap Linkage Disequilibrium report for ALOX5 (45869629 - 45941565 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 7 variations for ALOX5:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2567160CNV Deletion19546169
    esv2513283CNV Deletion19546169
    nsv895110CNV Loss21882294
    nsv895107CNV Loss21882294
    nsv466910CNV Loss19166990
    nsv895105CNV Gain21882294
    dgv651n71CNV Gain21882294

    Human Gene Mutation Database (HGMD): ALOX5
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing ALOX5
    DNA2.0 Custom Variant and Variant Library Synthesis for ALOX5

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 152390   
    OMIM disorders: 600807  
    11 diseases for ALOX5:    
    About MalaCards
    asthma, diminished response to antileukotriene treatment in    atherosclerosis    paranasal sinus disease    tuberculous meningitis
    arthus reaction    urticaria    glutathione synthetase deficiency    asthma
    primary pulmonary hypertension    osteoporosis    meningioma

    5 diseases from the University of Copenhagen DISEASES database for ALOX5:
    Asthma     Atherosclerosis     Arthritis     Pleurisy
    Cancer

    Find genes that share disorders with ALOX5           About GenesLikeMe

    Selected Novoseek inferred disease relationships for ALOX5 gene (see all 94)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    asthma 72.7 180 8473681 (4), 8129222 (4), 16364163 (4), 8598621 (4) (see all 98)
    inflammation 68.1 116 16250846 (3), 1309754 (2), 12733982 (2), 17305572 (2) (see all 90)
    leukemia basophilic 60.2 16 8071328 (2), 12005204 (1), 8140120 (1), 19243697 (1) (see all 12)
    asthma exercise-induced 59.4 5 8630575 (2), 16027142 (1), 10984370 (1), 17481554 (1)
    ear edema 59.3 4 1665293 (2), 7916384 (1), 9599246 (1)
    allergic rhinitis 50.8 7 12607939 (1), 9809497 (1), 9444606 (1), 1701029 (1) (see all 6)
    atherosclerosis 47 50 17481551 (2), 14702425 (2), 18842779 (2), 17825794 (2) (see all 31)
    anaphylaxis 46.7 9 8081074 (3), 1949224 (1), 8480540 (1), 9532969 (1) (see all 6)
    asthma allergic 45.2 7 8994519 (1), 9444606 (1), 1851340 (1), 17481554 (1) (see all 6)
    edema 44.7 20 7541689 (2), 1478686 (2), 8032607 (2), 9444606 (1) (see all 12)

    Genetic Association Database (GAD): ALOX5
    Human Genome Epidemiology (HuGE) Navigator: ALOX5 (78 documents)

    Export disorders for ALOX5 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ALOX5 gene, integrated from 10 sources (see all 1379):
    (articles sorted by number of sources associating them with ALOX5)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Arachidonate lipoxygenase (ALOX) and cyclooxygenase (COX) polymorphisms and colon cancer risk. (PubMed id 15308583)1, 2, 4 Goodman J.E.... Harris C.C. (Carcinogenesis 2004)
    2. Characterization of the human 5-lipoxygenase gene. (PubMed id 2565035)1, 2, 3 Funk C.D.... Samuelsson B. (Proc. Natl. Acad. Sci. U.S.A. 1989)
    3. Protein kinase A inhibits leukotriene synthesis by phosphorylation of 5-lipoxygenase on serine 523. (PubMed id 15280375)1, 2, 9 Luo M....Brock T.G. (J. Biol. Chem. 2004)
    4. Coactosin-like protein functions as a stabilizing chaperone for 5- lipoxygenase: role of tryptophan 102. (PubMed id 19807693)1, 2, 9 Esser J.... Radmark O. (Biochem. J. 2010)
    5. Phosphorylation of serine 271 on 5-lipoxygenase and its role in nuclear export. (PubMed id 18978352)1, 2, 9 Flamand N.... Brock T.G. (J. Biol. Chem. 2009)
    6. Arachidonic acid regulates the translocation of 5-lipoxygenase to the nuclear membranes in human neutrophils. (PubMed id 16275640)1, 2, 9 Flamand N.... Borgeat P. (J. Biol. Chem. 2006)
    7. Arachidonic acid promotes phosphorylation of 5-lipoxygenase at Ser- 271 by MAPK-activated protein kinase 2 (MK2). (PubMed id 11844797)1, 2, 9 Werz O.... Radmark O. (J. Biol. Chem. 2002)
    8. ALOX5 promoter genotype, asthma severity and LTC production by eosinophils. (PubMed id 16364163)1, 4, 9 Kalayci O....Lilly C. (Allergy 2006)
    9. 5-lipoxygenase and 5-lipoxygenase-activating protein are localized in the nuclear envelope of activated human leukocytes. (PubMed id 8245774)1, 2, 9 Woods J.W.... Singer I.I. (J. Exp. Med. 1993)
    10. Evaluation of the role of conserved His and Met residues among lipoxygenases by site-directed mutagenesis of recombinant human 5- lipoxygenase. (PubMed id 1939225)1, 2, 9 Nguyen T.... Riendeau D. (J. Biol. Chem. 1991)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 240 HGNC: 435 AceView: ALOX5 Ensembl:ENSG00000012779 euGenes: HUgn240
    ECgene: ALOX5 Kegg: 240 H-InvDB: ALOX5

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for ALOX5 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for ALOX5 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for ALOX5 gene:
    Search GeneIP for patents involving ALOX5

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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