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Aliases for ALOX15B Gene

Aliases for ALOX15B Gene

  • Arachidonate 15-Lipoxygenase, Type B 2 3 5
  • Arachidonate 15-Lipoxygenase, Second Type 2 3
  • Arachidonate 15-Lipoxygenase Type II 3 4
  • Linoleate 13-Lipoxygenase 15-LOb 3 4
  • EC 1.13.11.33 4 63
  • 15-LOX-2 3 4
  • 15-LOX-B 3 4
  • Arachidonate Omega(6) Lipoxygenase 3
  • Arachidonate 15-Lipoxygenase 2 3
  • 15-Lipoxygenase 2 4
  • 15S-Lipoxygenase 3
  • EC 1.13.11.- 4
  • EC 1.13.11 63

External Ids for ALOX15B Gene

Previous GeneCards Identifiers for ALOX15B Gene

  • GC17P008408
  • GC17P008813
  • GC17P007884
  • GC17P008142
  • GC17P007883
  • GC17P007942

Summaries for ALOX15B Gene

Entrez Gene Summary for ALOX15B Gene

  • This gene encodes a member of the lipoxygenase family of structurally related nonheme iron dioxygenases involved in the production of fatty acid hydroperoxides. The encoded protein converts arachidonic acid exclusively to 15S-hydroperoxyeicosatetraenoic acid, while metabolizing linoleic acid less effectively. This gene is located in a cluster of related genes and a pseudogene that spans approximately 100 kilobases on the short arm of chromosome 17. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]

GeneCards Summary for ALOX15B Gene

ALOX15B (Arachidonate 15-Lipoxygenase, Type B) is a Protein Coding gene. Diseases associated with ALOX15B include Prostate Cancer and Autosomal Recessive Congenital Ichthyosis. Among its related pathways are Arachidonic acid metabolism and Metabolism. GO annotations related to this gene include calcium ion binding and lipid binding. An important paralog of this gene is ALOX5.

UniProtKB/Swiss-Prot for ALOX15B Gene

  • Non-heme iron-containing dioxygenase that catalyzes the stereo-specific peroxidation of free and esterified polyunsaturated fatty acids generating a spectrum of bioactive lipid mediators. Converts arachidonic acid to 15S-hydroperoxyeicosatetraenoic acid/(15S)-HPETE. Also acts on linoleic acid to produce 13-hydroxyoctadecadienoic acid/13-HPODE. Has no detectable 8S-lipoxygenase activity but reacts with (8S)-HPETE to produce (8S,15S)-diHPETE. May regulate progression through the cell cycle and cell proliferation. May also regulate cytokine secretion by macrophages and therefore play a role in the immune response. May also regulate macrophage differentiation into proatherogenic foam cells.

Gene Wiki entry for ALOX15B Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ALOX15B Gene

Genomics for ALOX15B Gene

Regulatory Elements for ALOX15B Gene

Enhancers for ALOX15B Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around ALOX15B on UCSC Golden Path with GeneCards custom track

Promoters for ALOX15B Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around ALOX15B on UCSC Golden Path with GeneCards custom track

Genomic Location for ALOX15B Gene

Chromosome:
17
Start:
8,039,017 bp from pter
End:
8,049,134 bp from pter
Size:
10,118 bases
Orientation:
Plus strand

Genomic View for ALOX15B Gene

Genes around ALOX15B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ALOX15B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ALOX15B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ALOX15B Gene

Proteins for ALOX15B Gene

  • Protein details for ALOX15B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O15296-LX15B_HUMAN
    Recommended name:
    Arachidonate 15-lipoxygenase B
    Protein Accession:
    O15296
    Secondary Accessions:
    • D3DTR2
    • Q8IYQ2
    • Q8TEV3
    • Q8TEV4
    • Q8TEV5
    • Q8TEV6
    • Q9UKM4

    Protein attributes for ALOX15B Gene

    Size:
    676 amino acids
    Molecular mass:
    75857 Da
    Cofactor:
    Name=Fe cation; Xref=ChEBI:CHEBI:24875;
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAD37786.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for ALOX15B Gene

    Alternative splice isoforms for ALOX15B Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ALOX15B Gene

Proteomics data for ALOX15B Gene at MOPED

Selected DME Specific Peptides for ALOX15B Gene

Post-translational modifications for ALOX15B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ALOX15B Gene

Domains & Families for ALOX15B Gene

Gene Families for ALOX15B Gene

Suggested Antigen Peptide Sequences for ALOX15B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O15296

UniProtKB/Swiss-Prot:

LX15B_HUMAN :
  • The PLAT domain can bind calcium ions; this promotes association with membranes.
  • Belongs to the lipoxygenase family.
Domain:
  • The PLAT domain can bind calcium ions; this promotes association with membranes.
  • Contains 1 lipoxygenase domain.
  • Contains 1 PLAT domain.
Family:
  • Belongs to the lipoxygenase family.
genes like me logo Genes that share domains with ALOX15B: view

Function for ALOX15B Gene

Molecular function for ALOX15B Gene

UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=1100 uM for arachidonate (isoform D at pH 7.4 and 20 degrees Celsius) {ECO:0000269 PubMed:10542053}; KM=10 uM for linoleate (isoform A at pH 7.4 and 20 degrees Celsius) {ECO:0000269 PubMed:10542053}; KM=25 uM for arachidonate (isoform A at pH 7.4 and 20 degrees Celsius) {ECO:0000269 PubMed:10542053}; Vmax=4 umol/min/mg enzyme with arachidonate as substrate (isoform A at pH 7.4 and 20 degrees Celsius) {ECO:0000269 PubMed:10542053}; Vmax=2 umol/min/mg enzyme with arachidonate as substrate (isoform D at pH 7.4 and 20 degrees Celsius) {ECO:0000269 PubMed:10542053}; Vmax=4 umol/min/mg enzyme with linoleate as substrate (isoform A at pH 7.4 and 20 degrees Celsius) {ECO:0000269 PubMed:10542053};
UniProtKB/Swiss-Prot CatalyticActivity:
Arachidonate + O(2) = (5Z,8Z,11Z,13E)-(15S)-15-hydroperoxyicosa-5,8,11,13-tetraenoate.
UniProtKB/Swiss-Prot CatalyticActivity:
Linoleate + O(2) = (9Z,11E)-13-hydroxyoctadeca-9,11-dienoate.
UniProtKB/Swiss-Prot Function:
Non-heme iron-containing dioxygenase that catalyzes the stereo-specific peroxidation of free and esterified polyunsaturated fatty acids generating a spectrum of bioactive lipid mediators. Converts arachidonic acid to 15S-hydroperoxyeicosatetraenoic acid/(15S)-HPETE. Also acts on linoleic acid to produce 13-hydroxyoctadecadienoic acid/13-HPODE. Has no detectable 8S-lipoxygenase activity but reacts with (8S)-HPETE to produce (8S,15S)-diHPETE. May regulate progression through the cell cycle and cell proliferation. May also regulate cytokine secretion by macrophages and therefore play a role in the immune response. May also regulate macrophage differentiation into proatherogenic foam cells.
UniProtKB/Swiss-Prot Induction:
Up-regulated by UV-irradiation.

Enzyme Numbers (IUBMB) for ALOX15B Gene

Gene Ontology (GO) - Molecular Function for ALOX15B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IEA --
GO:0016702 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ALOX15B: view
genes like me logo Genes that share phenotypes with ALOX15B: view

Animal Model Products

  • Taconic Biosciences Mouse Models for ALOX15B

CRISPR Products

miRNA for ALOX15B Gene

miRTarBase miRNAs that target ALOX15B

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ALOX15B Gene

Localization for ALOX15B Gene

Subcellular locations from UniProtKB/Swiss-Prot for ALOX15B Gene

Isoform A: Nucleus. Note=Other isoforms are excluded from the nucleus.
Cytoplasm, cytosol. Cell membrane. Cytoplasm, cytoskeleton. Membrane; Peripheral membrane protein. Note=Predominantly cytosolic; becomes enriched at membranes upon calcium binding.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ALOX15B Gene COMPARTMENTS Subcellular localization image for ALOX15B gene
Compartment Confidence
cytoskeleton 5
cytosol 5
extracellular 5
nucleus 5
plasma membrane 5
peroxisome 1

Gene Ontology (GO) - Cellular Components for ALOX15B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005856 cytoskeleton IDA 12704195
GO:0016020 membrane IDA 10542053
GO:0070062 extracellular exosome IDA 23533145
genes like me logo Genes that share ontologies with ALOX15B: view

Pathways & Interactions for ALOX15B Gene

genes like me logo Genes that share pathways with ALOX15B: view

Pathways by source for ALOX15B Gene

UniProtKB/Swiss-Prot O15296-LX15B_HUMAN

  • Pathway: Lipid metabolism; hydroperoxy eicosatetraenoic acid biosynthesis.

Interacting Proteins for ALOX15B Gene

Gene Ontology (GO) - Biological Process for ALOX15B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006629 lipid metabolic process TAS 11839751
GO:0006915 apoptotic process TAS 11839751
GO:0010744 positive regulation of macrophage derived foam cell differentiation IMP 22912809
GO:0019369 arachidonic acid metabolic process IDA,TAS 9177185
GO:0019372 lipoxygenase pathway TAS --
genes like me logo Genes that share ontologies with ALOX15B: view

No data available for SIGNOR curated interactions for ALOX15B Gene

Drugs & Compounds for ALOX15B Gene

(2) Drugs for ALOX15B Gene - From: HMDB and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
arachidonic acid Experimental Nutra Activator 27
linoleic acid Pharma Full agonist, Agonist 0

(10) Additional Compounds for ALOX15B Gene - From: HMDB and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
13-L-Hydroperoxylinoleic acid
  • (13S,9z,11e)-13-hydroperoxy-9,11-octadecadienoate
  • (13S,9z,11e)-13-hydroperoxy-9,11-octadecadienoic acid
  • (9Z,11e)-(13S)-13-hydroperoxyoctadeca-9,11-dienoate
  • (9Z,11e)-(13S)-13-hydroperoxyoctadeca-9,11-dienoic acid
  • 13(S)-Hpode
33964-75-9
15(S)-HPETE
  • (5Z,8Z,11Z,13E)-(15S)-15-Hydroperoxyicosa-5,8,11,13-tetraenoate
  • (5Z,8Z,11Z,13E)-(15S)-15-Hydroperoxyicosa-5,8,11,13-tetraenoic acid
  • 15-Hydroperoxyeicosatetraenoate
  • 15-Hydroperoxyeicosatetraenoic acid
  • 15-Hydroperoxyicosatetraenoate
70981-96-3
8(S)-HPETE
  • 8-Peroxy-5Z,9E,11Z,14Z-eicosatetraenoate
  • 8-Peroxy-5Z,9E,11Z,14Z-eicosatetraenoic acid
  • 8S-HpETE
  • 8S-Hydoperoxy-5Z,9E,11Z,14Z-eicosatetraenoate
  • 8S-Hydoperoxy-5Z,9E,11Z,14Z-eicosatetraenoic acid
Fe2+
  • Armco iron
  • Carbonyl iron
  • FE
  • Ferrovac e
  • Hematite
15438-31-0
oxygen
  • Dioxygen
  • Molecular oxygen
  • O2
  • Oxygen
  • Oxygen molecule
7782-44-7
genes like me logo Genes that share compounds with ALOX15B: view

Transcripts for ALOX15B Gene

Unigene Clusters for ALOX15B Gene

Arachidonate 15-lipoxygenase, type B:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ALOX15B Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12a · 12b ^ 13 ^ 14a · 14b
SP1: - -
SP2: - - -
SP3: - - - - -
SP4:
SP5:

Relevant External Links for ALOX15B Gene

GeneLoc Exon Structure for
ALOX15B
ECgene alternative splicing isoforms for
ALOX15B

Expression for ALOX15B Gene

mRNA expression in normal human tissues for ALOX15B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ALOX15B Gene

This gene is overexpressed in Prostate (x7.5), Esophagus - Mucosa (x6.7), Lung (x6.3), Vagina (x5.5), and Skin - Not Sun Exposed (Suprapubic) (x4.7).

Protein differential expression in normal tissues from HIPED for ALOX15B Gene

This gene is overexpressed in Cervix (52.1) and Urine (8.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ALOX15B Gene



SOURCE GeneReport for Unigene cluster for ALOX15B Gene Hs.111256

mRNA Expression by UniProt/SwissProt for ALOX15B Gene

O15296-LX15B_HUMAN
Tissue specificity: Expressed in hair, prostate, lung, ovary, lymph node, spinal cord and cornea.
genes like me logo Genes that share expression patterns with ALOX15B: view

Primer Products

No data available for Protein tissue co-expression partners for ALOX15B Gene

Orthologs for ALOX15B Gene

This gene was present in the common ancestor of chordates.

Orthologs for ALOX15B Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia ALOX15B 35
  • 85.4 (n)
  • 82.99 (a)
ALOX15B 36
  • 78 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ALOX15B 35
  • 84.32 (n)
  • 81.36 (a)
ALOX15B 36
  • 75 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Alox8 35
  • 80.33 (n)
  • 78.11 (a)
Alox8 16
Alox8 36
  • 78 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia ALOX15B 35
  • 99.06 (n)
  • 98.67 (a)
ALOX15B 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Alox15b 35
  • 81.26 (n)
  • 80.62 (a)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 59 (a)
OneToMany
-- 36
  • 53 (a)
OneToMany
chicken
(Gallus gallus)
Aves ALOXE3 35
  • 59.95 (n)
  • 51.13 (a)
-- 36
  • 38 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 46 (a)
ManyToMany
-- 36
  • 49 (a)
ManyToMany
-- 36
  • 53 (a)
ManyToMany
-- 36
  • 51 (a)
ManyToMany
-- 36
  • 48 (a)
ManyToMany
-- 36
  • 48 (a)
ManyToMany
African clawed frog
(Xenopus laevis)
Amphibia Xl.25238 35
zebrafish
(Danio rerio)
Actinopterygii ALOXE3 36
  • 40 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 29 (a)
ManyToMany
-- 36
  • 34 (a)
ManyToMany
-- 36
  • 29 (a)
ManyToMany
CSA.6148 36
  • 30 (a)
ManyToMany
Species with no ortholog for ALOX15B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ALOX15B Gene

ENSEMBL:
Gene Tree for ALOX15B (if available)
TreeFam:
Gene Tree for ALOX15B (if available)

Paralogs for ALOX15B Gene

Paralogs for ALOX15B Gene

(6) SIMAP similar genes for ALOX15B Gene using alignment to 2 proteins:

Pseudogenes.org Pseudogenes for ALOX15B Gene

genes like me logo Genes that share paralogs with ALOX15B: view

Variants for ALOX15B Gene

Sequence variations from dbSNP and Humsavar for ALOX15B Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs4792147 - 8,048,501(+) GAACC(A/C/G)GGGCC reference, missense
rs7225107 - 8,048,560(+) TCTCC(A/G)TCTAA reference, missense
rs9895916 - 8,047,076(+) GGAAC(A/G)GTGAG intron-variant, reference, missense
rs1804772 -- 8,048,687(+) ACAAC(A/C)AGACT utr-variant-3-prime
rs1132934 -- 8,048,913(+) GCCCC(A/G)GGGCC utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for ALOX15B Gene

Variant ID Type Subtype PubMed ID
nsv833352 CNV Loss 17160897
nsv528325 CNV Loss 19592680

Variation tolerance for ALOX15B Gene

Residual Variation Intolerance Score: 96.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 9.38; 88.45% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for ALOX15B Gene

Disorders for ALOX15B Gene

MalaCards: The human disease database

(2) MalaCards diseases for ALOX15B Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
prostate cancer
  • prostate cancer, hereditary, 5
autosomal recessive congenital ichthyosis
  • autosomal recessive lamellar ichthyosis
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for ALOX15B

Genetic Association Database (GAD)
ALOX15B
Human Genome Epidemiology (HuGE) Navigator
ALOX15B
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ALOX15B
genes like me logo Genes that share disorders with ALOX15B: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ALOX15B Gene

Publications for ALOX15B Gene

  1. Discovery of a second 15S-lipoxygenase in humans. (PMID: 9177185) Brash A.R. … Chang M.S. (Proc. Natl. Acad. Sci. U.S.A. 1997) 2 3 4 23 67
  2. Downregulation of 15-lipoxygenase 2 by glucocorticoid receptor in prostate cancer cells. (PMID: 20428779) Feng Y. … Wang D. (Int. J. Oncol. 2010) 3 23
  3. 15-Lipoxygenase-2 expression in human macrophages induces chemokine secretion and T cell migration. (PMID: 18067895) Danielsson K.N. … HultAcn L.M. (Atherosclerosis 2008) 3 23
  4. Loss of heterozygosity of 17p13, with possible involvement of ACADVL and ALOX15B, in the pathogenesis of adrenocortical tumors. (PMID: 18156936) Soon P.S. … Robinson B.G. (Ann. Surg. 2008) 3 23
  5. Novel mutations in ALOX12B in patients with autosomal recessive congenital ichthyosis and evidence for genetic heterogeneity on chromosome 17p13. (PMID: 17139268) Lesueur F. … Fischer J. (J. Invest. Dermatol. 2007) 3 23

Products for ALOX15B Gene

Sources for ALOX15B Gene

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