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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ALOX15B Gene

protein-coding   GIFtS: 59
GCID: GC17P007942

arachidonate 15-lipoxygenase, type B

(Previous names: arachidonate 15-lipoxygenase, second type )
 Explore 27 diseases affiliated with
ALOX15B via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for ALOX15B    

Aliases
for ALOX15B gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Arachidonate 15-Lipoxygenase, Type B1 2     15S-Lipoxygenase1
15-LOX-21 2 3     Arachidonate 15-Lipoxygenase 22
Arachidonate 15-Lipoxygenase, Second Type1 2     Arachidonate 15-Lipoxygenase B2
Arachidonate 15-Lipoxygenase Type II2 3     Arachidonate Omega(6) Lipoxygenase2
15-LOX-B2 3     15-Lipoxygenase 23
EC 1.13.11.333 8     EC 1.13.118

External Ids:    HGNC: 4341   Entrez Gene: 2472   Ensembl: ENSG000001795937   OMIM: 6036975   UniProtKB: O152963   

Export aliases for ALOX15B gene to outside databases

Previous GC identifers: GC17P008408 GC17P008813 GC17P007884 GC17P008142 GC17P007883


Summaries
for ALOX15B gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for ALOX15B:
This gene encodes a member of the lipoxygenase family of structurally related nonheme iron dioxygenases involved in the
production of fatty acid hydroperoxides. The encoded protein converts arachidonic acid exclusively to
15S-hydroperoxyeicosatetraenoic acid, while metabolizing linoleic acid less effectively. This gene is located in a
cluster of related genes and a pseudogene that spans approximately 100 kilobases on the short arm of chromosome 17.
Alternatively spliced transcript variants encoding different isoforms have been described. (provided by RefSeq, Jul
2008)

UniProtKB/Swiss-Prot: LX15B_HUMAN, O15296
Function: Converts arachidonic acid exclusively to 15S-hydroperoxyeicosatetraenoic acid, while linoleic acid is less
well metabolized

Gene Wiki entry for ALOX15B


Genomic Views
for ALOX15B gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000017.10  NC_018928.1  NT_010718.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ALOX15B gene promoter:
         CREB   GR   AhR   PPAR-gamma1   POU3F1   GR-beta   SEF-1 (1)   GR-alpha   LCR-F1   RORalpha2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: ALOX15B promoter sequence
   Search SABiosciences Chromatin IP Primers for ALOX15B

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ALOX15B


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17p13.1   Ensembl cytogenetic band:  17p13.1   HGNC cytogenetic band: 17p13.1

ALOX15B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ALOX15B gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17P007942:  view genomic region     (about GC identifiers)

Start:
 7,942,335 bp from pter      End:
 7,952,452 bp from pter
Size:
 10,118 bases      Orientation:
 plus strand

Proteins
for ALOX15B gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: LX15B_HUMAN, O15296 (See protein sequence)
Recommended Name: Arachidonate 15-lipoxygenase B  
Size: 676 amino acids; 75857 Da
Cofactor: Binds 1 iron ion per subunit (By similarity)
Subcellular location: Cytoplasm (By similarity)
Sequence caution: Sequence=AAD37786.1; Type=Erroneous gene model prediction;
Secondary accessions: D3DTR2 Q8IYQ2 Q8TEV3 Q8TEV4 Q8TEV5 Q8TEV6 Q9UKM4
Alternative splicing: 4 isoforms:  O15296-1   O15296-2   O15296-3   O15296-4   

Explore the universe of human proteins at neXtProt for ALOX15B: NX_O15296

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_O15296

    • 3 DME Specific Peptides for ALOX15B (O15296)
     NPVLIRRC  YPDEHFTE  TCSAKHAAV 

    ALOX15B Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (3 alternative transcripts): 
    NP_001034219.1  NP_001034220.1  NP_001132.2  

    ENSEMBL proteins: 
     ENSP00000369530   ENSP00000458749   ENSP00000460332   ENSP00000369520  
    Reactome Protein details: O15296
    Human Recombinant Protein Products: 
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    Uscn Proteins for ALOX15B

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular IDA11839751
    GO:0005737cytoplasm IEA--


    ALOX15B for ontologies           About GeneDecksing



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    Uscn ELISAs and CLIAs for ALOX15B

    Protein Domains /
    Families
    for ALOX15B gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    ALOX15B for domains           About GeneDecksing

    5/7 InterPro domains/families (see all 7):
     IPR020833 LipOase_Fe_BS
     IPR013819 LipOase_C
     IPR001024 LipOase_LH2
     IPR008976 Lipase_LipOase
     IPR020834 LipOase_CS

    Graphical View of Domain Structure for InterPro Entry O15296

    ProtoNet protein and cluster: O15296

    3 Blocks protein families:
    IPB000907 Lipoxygenase
    IPB001024 Lipoxygenase
    IPB001885 Mammalian lipoxygenase signature


    UniProtKB/Swiss-Prot: LX15B_HUMAN, O15296
    Similarity: Belongs to the lipoxygenase family
    Similarity: Contains 1 lipoxygenase domain
    Similarity: Contains 1 PLAT domain


    Function
    for ALOX15B gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: LX15B_HUMAN, O15296
    Function: Converts arachidonic acid exclusively to 15S-hydroperoxyeicosatetraenoic acid, while linoleic acid is less
    well metabolized
    Catalytic activity: Arachidonate + O(2) = (5Z,8Z,11Z,13E)-(15S)-15-hydroperoxyicosa-5,8,11,13-tetraenoate

    Enzyme Numbers (IUBMB): EC 1.13.11.331 2 EC 1.13.112

    miRNA
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    hsa-miR-2052 hsa-miR-330-5p hsa-miR-326 hsa-miR-26b* hsa-miR-323b-5p
    SwitchGear 3'UTR luciferase reporter plasmid: ALOX15B 3' UTR sequence
    Inhib. RNA
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    Gene Editing
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    Clone
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    Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005506iron ion binding IEA--
    GO:0016165lipoxygenase activity IEA--
    GO:0050473arachidonate 15-lipoxygenase activity IDA11839751


    ALOX15B for ontologies           About GeneDecksing



    Pathways & Interactions
    for ALOX15B gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Arachidonic acid metabolism
    		Arachidonic acid metabolism1.00
    		HETE and HPETE biosynthesis and metabolism0.39
    		Arachidonic acid metabolism0.42
    		Eicosanoid Synthesis0.31
    		HETE and HPETE biosynthesis and metabolism0.39
    2Metabolism
    		Metabolism1.00
    		Metabolism of lipids and lipoproteins0.34
    		Metabolic pathways0.38
    3Synthesis of 15-eicosatetraenoic acid derivatives
    		Synthesis of 15-eicosatetraenoic acid derivatives1.00
    4Selenium Pathway
    		Selenium Pathway1.00

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    1 EMD Millipore Pathway for ALOX15B
        HETE and HPETE biosynthesis and metabolism


    1 GeneGo (Thomson Reuters) Pathway for ALOX15B
        HETE and HPETE biosynthesis and metabolism

    2 BioSystems Pathways for ALOX15B 
        Eicosanoid Synthesis
    Selenium Pathway

    4        Reactome Pathways for ALOX15B
        Metabolism
    Arachidonic acid metabolism
    Synthesis of 15-eicosatetraenoic acid derivatives
    Metabolism of lipids and lipoproteins


    2         Kegg Pathways  (Kegg details for ALOX15B):
        Arachidonic acid metabolism
    Metabolic pathways

    UniProtKB/Swiss-Prot: LX15B_HUMAN, O15296
    Pathway: Lipid metabolism; leukotriene D4 biosynthesis


    ALOX15B for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for ALOX15B

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/42 Interacting proteins for ALOX15B (ENSP000003695304) via UniProtKB, MINT, STRING, and/or I2D (see all 42)

    InteractantInteraction Details
    GeneCardExternal ID(s)
    ALOX12ENSP000002515354STRING: ENSP00000251535
    ALOX12BENSP000003151674STRING: ENSP00000315167
    ALOX15ENSP000002937614STRING: ENSP00000293761
    ALOX5ENSP000003635124STRING: ENSP00000363512
    CYP2B6ENSP000003246484STRING: ENSP00000324648
    About this table

    Gene Ontology (GO): 5/11 biological process terms (GO ID links to tree view) (see all 11):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006629lipid metabolic process TAS11839751
    GO:0006631fatty acid metabolic process TAS9177185
    GO:0006691leukotriene metabolic process ----
    GO:0006917induction of apoptosis TAS11839751
    GO:0008285negative regulation of cell proliferation IDA11839751


    ALOX15B for ontologies           About GeneDecksing



    Drugs & Compounds
    for ALOX15B gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    ALOX15B for compounds           About GeneDecksing

    EMD Millipore small molecules for ALOX15B:
    Small Molecule - inhibitor
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    Browse Tocris compounds for ALOX15B

    7 HMDB Compounds for ALOX15B    About this table
    CompoundSynonyms CAS #PubMed Ids
    13-L-Hydroperoxylinoleic acid(13S,9z,11e)-13-hydroperoxy-9,11-octadecadienoic acid (see all 18)33964-75-9--
    15(S)-HPETE(5Z,8Z,11Z,13E)-(15S)-15-Hydroperoxyicosa-5,8,11,13-tetraenoate (see all 8)70981-96-3--
    8(S)-HPETE8S-hydoperoxy-5Z,9E,11Z,14Z-eicosatetraenoic acid (see all 3)----
    Arachidonic acid5,8,11,14-Eicosatetraenoic acid (see all 16)506-32-1--
    IronArmco iron (see all 19)7439-89-6--
    Linoleic acid(9Z,12Z)-9,12-Octadecadienoate (see all 26)60-33-3--
    OxygenOxygen (see all 5)7782-44-7--
    7 Novoseek chemical compound relationships for ALOX15B gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    15-hydroxyeicosatetraenoic acid 88.3 7 11571629 (3), 11442747 (1), 15533897 (1), 18202670 (1)
    arachidonic acid 74.1 20 9177185 (2), 12727848 (1), 12704195 (1), 11212240 (1) (see all 13)
    ns 398 59.8 3 12659684 (1), 16874012 (1)
    linoleic acid 54.5 2 9177185 (1), 16566819 (1)
    phorbol 48.7 1 10625675 (1)
    paraffin 12 2 11014584 (1)
    steroid 0 1 16682954 (1)

    Search CenterWatch for drugs/clinical trials and news about ALOX15B / LX15B 

    Transcripts
    for ALOX15B gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for ALOX15B gene (3 alternative transcripts): 
    NM_001039130.1  NM_001039131.1  NM_001141.2  

    Unigene Cluster for ALOX15B:

    Arachidonate 15-lipoxygenase, type B
    Hs.111256  [show with all ESTs]
    Unigene Representative Sequence: BC033294
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000380183(uc002gju.3 uc002gjv.3 uc002gjw.3 uc010vun.2)
    ENST00000572022 ENST00000571240(uc010cnp.3) ENST00000573359 ENST00000380173


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    hsa-miR-2052 hsa-miR-330-5p hsa-miR-326 hsa-miR-26b* hsa-miR-323b-5p
    SwitchGear 3'UTR luciferase reporter plasmid: ALOX15B 3' UTR sequence
    Inhib. RNA
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    Clone
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    Additional cDNA sequence: 

    AF468051.1 AF468052.1 AF468053.1 AF468054.1 AK292779.1 AK298095.1 AK300554.1 BC033294.1 
    BC035217.1 BC063647.1 U78294.1 

    7 DOTS entries:

    DT.108481  DT.101981385  DT.97790313  DT.97836298  DT.102822610  DT.92419921  DT.99958412 

    24/63 AceView cDNA sequences (see all 63):

    CB051073 AI817643 CA307212 AI829771 AI695749 BG739709 AI474406 BG740579 
    BX106451 BG743327 BG674800 AW294456 BG675344 BC063647 BG696804 BX371551 
    AF468053 AA595521 BX371550 BC033294 U78294 BG739941 AF468052 BI489877 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for ALOX15B    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12a · 12b ^ 13 ^ 14a · 14b
    SP1:                          -                                                                 -                           
    SP2:                          -                                         -                       -                           
    SP3:                          -                                         -           -     -     -                           
    SP4:                                                                                                                        
    SP5:                                                                                                                        


    ECgene alternative splicing isoforms for ALOX15B

    Expression
    for ALOX15B gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ALOX15B expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: CCCATAATCC

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image
    See ALOX15B Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ALOX15B

    SOURCE GeneReport for Unigene cluster: Hs.111256

    UniProtKB/Swiss-Prot: LX15B_HUMAN, O15296
    Tissue specificity: Expressed in hair, prostate, lung and cornea

        SABiosciences Expression via Pathway-Focused PCR Array including ALOX15B: 
              Apoptosis 384HT in human mouse rat

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    In Situ
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    Orthologs
    for ALOX15B gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of eukaryotes.

    Orthologs for ALOX15B gene from 6/19 species (see all 19)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves ALOX15B6
    		 --
    		 50(a)
    		 1 → many
    		 Un(27690087-27694842)
    lizard
    (Anolis carolinensis)    		 Reptilia --
    --
    (see all 5)    		 --
    		 49(a)
    48(a)
    (see all 5)    		 many ↔ many
    many ↔ many
    (see all 5)    		 GL343400.1(642744-660332)
    GL343400.1(748887-766338)
    African clawed frog
    (Xenopus laevis)    		 Amphibia Xl.252382 Xenopus laevis transcribed sequence with weak similarity more 73.98(n)    BJ627300.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii zgc:1528916
    si:dkey-17e16.96
    		 si:dkey-17e16.9
    		 40(a)
    38(a)
    		 many ↔ many
    many ↔ many
    		 21(29958222-29989099)
    21(24924940-24935413)
    thale cress
    (Arabidopsis thaliana)    		 eudicotyledons LOX56
    LOX16
    (see all 6)    		 lipoxygenase 1
    (see all 6)    		 20(a)
    20(a)
    (see all 6)    		 many ↔ many
    many ↔ many
    (see all 6)    		 3(7926879-7931351)
    1(20525708-20530273)
    rice
    (Oryza sativa)    		 Liliopsida --
    --
    (see all 13)    		 lipozygenase protein, putative, expressed
    (see all 13)    		 26(a)
    23(a)
    (see all 13)    		 many ↔ many
    many ↔ many
    (see all 13)    		 12(22901276-22903277)
    3(28084665-28087667)


    ENSEMBL Gene Tree for ALOX15B (if available)
    TreeFam Gene Tree for ALOX15B (if available) 

    Paralogs
    for ALOX15B gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ALOX15B gene
    ALOX12B2  ALOX52  ALOX122  ALOX152  ALOXE32  
    6 SIMAP similar genes for ALOX15B using alignment to 2 protein entries:     LX15B_HUMAN (see all proteins):
    arachidonate 12-lipoxygenase    ALOX12B    ALOXE3    ALOX5    ALOX15    ALOX12

    ALOX15B for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for ALOX15B
    PGOHUM00000262362


    Genomic Variants
    for ALOX15B gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/321 NCBI SNPs in ALOX15B are shown (see all 321)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 17 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1117829661,2
    		--7835273(+) GTAGCC/TGGAAT 3 -- us2k11Minor allele frequency- T:0.50CSA 2
    rs758019371,2
    		--7835889(+) AATCCA/GTAACT 3 -- us2k12Minor allele frequency- G:0.07CSA WA 120
    rs739726481,2
    		C,--7835905(+) TTGGCA/GTCTCT 3 -- us2k12Minor allele frequency- G:0.04WA 120
    rs792352391,2
    		C,--7836159(+) TACTTA/GTTTTC 3 -- us2k13Minor allele frequency- G:0.03WA NA 240
    rs98980711,2
    		C,--7836657(+) aaaatA/Ccaaaa 3 -- us2k10--------
    rs1161060311,2
    		C,F,--7838383(+) GGTGCC/TGTGGT 3 -- int11Minor allele frequency- T:0.14WA 118
    rs1123223871,2
    		C,--7838872(+) CCAGAA/GATCTG 3 -- int13Minor allele frequency- G:0.03NA WA 240
    rs786271151,2
    		C,--7839122(+) GATCCG/AGCCAA 3 -- int14Minor allele frequency- A:0.02NA CSA WA 241
    rs39348491,2
    		C,F,H,--7839168(-) GACCAG/AGAGCA 3 -- int16Minor allele frequency- A:0.06NA WA 246
    rs585206631,2
    		C,F,--7839903(+) TGCCTC/TGGGCG 3 -- int14Minor allele frequency- T:0.07WA NA 242

    HapMap Linkage Disequilibrium report for ALOX15B (7942335 - 7952452 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 1 variation for ALOX15B
         1 CNV: 4988

    SABiosciences Cancer Mutation PCR Assays
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    DNA2.0 Custom Variant and Variant Library Synthesis for ALOX15B

    Disorders / Diseases
    for ALOX15B gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    ALOX15B for disorders           About GeneDecksing

    OMIM gene information: 603697    OMIM disorders: --

    20/27 diseases for ALOX15B (see all 27):    About MalaCards
    congenital ichthyosiform erythroderma    autosomal recessive congenital ichthyosis    ichthyosis    inflammatory bowel disease
    epithelial ovarian cancer    adrenocortical tumor    squamous cell carcinoma    prostate adenocarcinoma
    prostatitis    prostate cancer    prostate cancer, progression of    ovarian cancer
    prostate carcinoma    adenocarcinoma    carcinoma    esophageal cancer
    esophagitis    meningioma    psoriasis    breast carcinoma

    10/13 Novoseek disease relationships for ALOX15B gene (see all 13)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    prostate carcinoma 55 9 11014584 (2), 11212240 (1), 15257547 (1), 12189136 (1) (see all 5)
    prostatic adenocarcinoma 52.7 9 10393855 (4), 11014584 (1), 11442747 (1)
    prostatic intraepithelial neoplasia 44.9 1 11014584 (1)
    prostate cancer 41.9 18 11839751 (5), 20428779 (2), 12189136 (2), 12085962 (1) (see all 7)
    hnscc 38.1 2 16874012 (1)
    tumors 27.5 55 11014584 (7), 12704195 (3), 15257547 (3), 15799828 (3) (see all 13)
    premalignant 23.8 1 12659684 (1)
    carcinoma squamous cell 14.3 3 16581564 (1), 16874012 (1)
    carcinoma 14 10 16874012 (5), 16581564 (1), 15257547 (1), 11442747 (1)
    inflammation 4.7 1 19912316 (1)

    Human Genome Epidemiology (HuGE) Navigator: ALOX15B (7 documents)

    Export disorders for ALOX15B gene to outside databases

    Publications
    for ALOX15B gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ALOX15B gene, integrated from 9 sources (see all 79):
    (articles sorted by number of sources associating them with ALOX15B)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Discovery of a second 15S-lipoxygenase in humans. (PubMed id 9177185)1, 2, 3, 9 Brash A.R.... Chang M.S. (1997)
    2. Evidence that arachidonate 15-lipoxygenase 2 is a negative cell cycle regulator in normal prostate epithelial cells. (PubMed id 11839751)1, 2, 9 Tang S.... Tang D.G. (2002)
    3. A gene cluster encoding human epidermis-type lipoxygenases at chromosome 17p13.1: cloning, physical mapping, and expression. (PubMed id 11350124)1, 2, 9 Krieg P.... Fuerstenberger G. (2001)
    4. Differential characteristics of human 15-lipoxygenase isozymes and a novel splice variant of 15S-lipoxygenase. (PubMed id 10542053)1, 2, 9 Kilty I.... Vickers P.J. (1999)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    6. Subcellular localization and tumor-suppressive functions of 15-lipoxygenase 2 (15-LOX2) and its splice variants. (PubMed id 12704195)1, 9 Bhatia B....Tang D.G. (2003)
    7. Reduction of isoforms of 15-lipoxygenase (15-LOX)-1 and 15-LOX-2 in human breast cancer. (PubMed id 16556493)1, 9 Jiang W.G....Mansel R.E. (2006)
    8. Evidence that Sp1 positively and Sp3 negatively regulate and androgen does not directly regulate functional tumor suppressor 15-lipoxygenase 2 (15-LOX2) gene expression in normal human prostate epithelial cells. (PubMed id 15247906)1, 9 Tang S....Tang D.G. (2004)
    9. 15-Lipoxygenase-2 gene regulation by its product 15-(S)-hydroxyeicosatetraenoic acid through a negative feedback mechanism that involves peroxisome proliferator-activated receptor gamma. (PubMed id 16682954)1, 9 Subbarayan V....Menter D.G. (2006)
    10. Downregulation of 15-lipoxygenase 2 by glucocorticoid receptor in prostate cancer cells. (PubMed id 20428779)1, 9 Feng Y....Wang D. (2010)

    External Searches for ALOX15B gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing ALOX15B gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 247 HGNC: 434 AceView: ALOX15B Ensembl:ENSG00000179593 euGenes: HUgn247
    ECgene: ALOX15B Kegg: 247 H-InvDB: ALOX15B

    Other Databases showing ALOX15B gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing ALOX15B gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ALOX15B Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for ALOX15B gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for ALOX15B gene:
    Search GeneIP for patents involving ALOX15B

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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