Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ALOX15B Gene

protein-coding   GIFtS: 63
GCID: GC17P007942

Arachidonate 15-Lipoxygenase, Type B

(Previous names: arachidonate 15-lipoxygenase, second type)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Arachidonate 15-Lipoxygenase, Type B1 2     15S-lipoxygenase2
Arachidonate 15-Lipoxygenase, Second Type1 2     Arachidonate 15-Lipoxygenase 22
Arachidonate 15-Lipoxygenase Type II2 3     Arachidonate 15-Lipoxygenase B2
15-LOX-22 3     Arachidonate Omega(6) Lipoxygenase2
15-LOX-B2 3     15-Lipoxygenase 23
EC 1.13.11.333 8     EC 1.13.118

External Ids:    HGNC: 4341   Entrez Gene: 2472   Ensembl: ENSG000001795937   OMIM: 6036975   UniProtKB: O152963   

Export aliases for ALOX15B gene to outside databases

Previous GC identifers: GC17P008408 GC17P008813 GC17P007884 GC17P008142 GC17P007883


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for ALOX15B Gene:
This gene encodes a member of the lipoxygenase family of structurally related nonheme iron dioxygenases involved
in the production of fatty acid hydroperoxides. The encoded protein converts arachidonic acid exclusively to
15S-hydroperoxyeicosatetraenoic acid, while metabolizing linoleic acid less effectively. This gene is located in
a cluster of related genes and a pseudogene that spans approximately 100 kilobases on the short arm of chromosome
17. Alternatively spliced transcript variants encoding different isoforms have been described. (provided by
RefSeq, Jul 2008)

GeneCards Summary for ALOX15B Gene: 
ALOX15B (arachidonate 15-lipoxygenase, type B) is a protein-coding gene. Diseases associated with ALOX15B include autosomal recessive congenital ichthyosis, and prostate adenocarcinoma, and among its related super-pathways are Arachidonic acid metabolism and Metabolic pathways. GO annotations related to this gene include arachidonate 15-lipoxygenase activity and iron ion binding. An important paralog of this gene is ALOX12B.

UniProtKB/Swiss-Prot: LX15B_HUMAN, O15296
Function: Converts arachidonic acid exclusively to 15S-hydroperoxyeicosatetraenoic acid, while linoleic acid is
less well metabolized

Gene Wiki entry for ALOX15B Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000017.10  NT_010718.16  NC_018928.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ALOX15B gene promoter:
         CREB   GR   AhR   PPAR-gamma1   POU3F1   GR-beta   SEF-1 (1)   GR-alpha   LCR-F1   RORalpha2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidALOX15B promoter sequence
   Search SABiosciences Chromatin IP Primers for ALOX15B

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ALOX15B


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17p13.1   Ensembl cytogenetic band:  17p13.1   HGNC cytogenetic band: 17p13.1

ALOX15B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ALOX15B gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17P007942:  view genomic region     (about GC identifiers)

Start:
7,942,335 bp from pter      End:
7,952,452 bp from pter
Size:
10,118 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: LX15B_HUMAN, O15296 (See protein sequence)
Recommended Name: Arachidonate 15-lipoxygenase B  
Size: 676 amino acids; 75857 Da
Cofactor: Binds 1 iron ion per subunit (By similarity)
Subcellular location: Cytoplasm (By similarity)
Sequence caution: Sequence=AAD37786.1; Type=Erroneous gene model prediction;
Secondary accessions: D3DTR2 Q8IYQ2 Q8TEV3 Q8TEV4 Q8TEV5 Q8TEV6 Q9UKM4
Alternative splicing: 4 isoforms:  O15296-1   O15296-2   O15296-3   O15296-4   

Explore the universe of human proteins at neXtProt for ALOX15B: NX_O15296

Explore proteomics data for ALOX15B at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_O15296

  • 3 DME Specific Peptides for ALOX15B (O15296)
     NPVLIRRC  YPDEHFTE  TCSAKHAAV 

    ALOX15B Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    ALOX15B Protein Expression
    REFSEQ proteins (3 alternative transcripts): 
    NP_001034219.1  NP_001034220.1  NP_001132.2  

    ENSEMBL proteins: 
     ENSP00000369530   ENSP00000458749   ENSP00000460332   ENSP00000369520  
    Reactome Protein details: O15296
    Human Recombinant Protein Products for ALOX15B: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for ALOX15B
    OriGene Custom MassSpec 
    OriGene Custom Protein Services for ALOX15B
    GenScript Custom Purified and Recombinant Proteins Services for ALOX15B
    Novus Biologicals ALOX15B Proteins
    Novus Biologicals ALOX15B Lysate
    Sino Biological Recombinant Protein for ALOX15B
    Sino Biological Cell Lysate for ALOX15B 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for ALOX15B 

    Gene Ontology (GO): 5/6 cellular component terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular IDA11839751
    GO:0005634nucleus IEA--
    GO:0005829cytosol TAS--
    GO:0005856cytoskeleton IDA12704195
    GO:0005886plasma membrane IDA12704195

    ALOX15B for ontologies           About GeneDecksing



    ALOX15B Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for ALOX15B
    GenScript Custom Superior Antibodies Services for ALOX15B
    Novus Biologicals ALOX15B Antibodies
    Abcam antibodies for ALOX15B
    Cloud-Clone Corp. Antibodies for ALOX15B 
    ThermoFisher Antibodies for ALOX15B
    LSBio Antibodies in human, mouse, rat for ALOX15B 

    Assay Products for ALOX15B: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for ALOX15B
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for ALOX15B
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for ALOX15B 
    Cloud-Clone Corp. CLIAs for ALOX15B


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    ALOX: Arachidonate lipoxygenases

    IUPHAR Guide to PHARMACOLOGY protein family classification: 15-LOX-2 
    Lipoxygenases

    5/7 InterPro protein domains (see all 7):
     IPR020833 LipOase_Fe_BS
     IPR013819 LipOase_C
     IPR001024 LipOase_LH2
     IPR008976 Lipase_LipOase
     IPR020834 LipOase_CS

    Graphical View of Domain Structure for InterPro Entry O15296

    ProtoNet protein and cluster: O15296

    3 Blocks protein domains:
    IPB000907 Lipoxygenase
    IPB001024 Lipoxygenase
    IPB001885 Mammalian lipoxygenase signature


    UniProtKB/Swiss-Prot: LX15B_HUMAN, O15296
    Similarity: Belongs to the lipoxygenase family
    Similarity: Contains 1 lipoxygenase domain
    Similarity: Contains 1 PLAT domain


    ALOX15B for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: LX15B_HUMAN, O15296
    Function: Converts arachidonic acid exclusively to 15S-hydroperoxyeicosatetraenoic acid, while linoleic acid is
    less well metabolized
    Catalytic activity: Arachidonate + O(2) = (5Z,8Z,11Z,13E)-(15S)-15-hydroperoxyicosa-5,8,11,13-tetraenoate

         Enzyme Numbers (IUBMB): EC 1.13.11.331 2 EC 1.13.112

         Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005506iron ion binding IEA--
    GO:0005515protein binding ----
    GO:0016165linoleate 13S-lipoxygenase activity IDA10542053
    GO:0016702oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen ----
    GO:0046872metal ion binding ----
         
    ALOX15B for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for ALOX15B 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for ALOX15B

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for ALOX15B 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for ALOX15B 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ALOX15B
    5 QIAGEN miScript miRNA Assays for microRNAs that regulate ALOX15B:
    hsa-miR-2052 hsa-miR-330-5p hsa-miR-326 hsa-miR-26b* hsa-miR-323b-5p
    SwitchGear 3'UTR luciferase reporter plasmidALOX15B 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for ALOX15B
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ALOX15B

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for ALOX15B
    Sirion Biotech Customized adenovirus for overexpression of ALOX15B

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for ALOX15B (see all 15)
    OriGene ORF clones in mouse, rat for ALOX15B
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 3): ALOX15B (NM_001141)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ALOX15B
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ALOX15B
    Sirion Biotech Customized lentivirus for stable overexpression of ALOX15B 
                         Customized lentivirus expression plasmids for stable overexpression of ALOX15B 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for ALOX15B
    Search LifeMap BioReagents cell lines for ALOX15B
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ALOX15B


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for ALOX15B About   (see all 6)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Arachidonic acid metabolism
    Arachidonic acid metabolism0.44
    HETE and HPETE biosynthesis and metabolism0.35
    Arachidonic acid metabolism0.44
    2Metabolism
    Metabolism0.40
    Metabolism of lipids and lipoproteins0.34
    Metabolic pathways0.40
    3Synthesis of 15-eicosatetraenoic acid derivatives
    Synthesis of 15-eicosatetraenoic acid derivatives0.50
    4Circadian entrainment
    Serotonergic synapse0.33
    5Selenium Pathway
    Selenium Pathway

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 EMD Millipore Pathway for ALOX15B
        HETE and HPETE biosynthesis and metabolism


    1 GeneGo (Thomson Reuters) Pathway for ALOX15B
        HETE and HPETE biosynthesis and metabolism

    2 BioSystems Pathways for ALOX15B
        Eicosanoid Synthesis
    Selenium Pathway


    4        Reactome Pathways for ALOX15B
        Metabolism
    Arachidonic acid metabolism
    Synthesis of 15-eicosatetraenoic acid derivatives
    Metabolism of lipids and lipoproteins


    3         Kegg Pathways  (Kegg details for ALOX15B):
        Arachidonic acid metabolism
    Metabolic pathways
    Serotonergic synapse

    UniProtKB/Swiss-Prot: LX15B_HUMAN, O15296
    Pathway: Lipid metabolism; leukotriene D4 biosynthesis


    ALOX15B for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for ALOX15B

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/42 Interacting proteins for ALOX15B (ENSP000003695304) via UniProtKB, MINT, STRING, and/or I2D (see all 42)

    InteractantInteraction Details
    GeneCardExternal ID(s)
    ALOX12ENSP000002515354STRING: ENSP00000251535
    ALOX12BENSP000003151674STRING: ENSP00000315167
    ALOX15ENSP000002937614STRING: ENSP00000293761
    ALOX5ENSP000003635124STRING: ENSP00000363512
    CYP2B6ENSP000003246484STRING: ENSP00000324648
    About this table

    Gene Ontology (GO): 5/18 biological process terms (GO ID links to tree view) (see all 18):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006629lipid metabolic process TAS11839751
    GO:0006631fatty acid metabolic process ----
    GO:0006691leukotriene metabolic process ----
    GO:0006915apoptotic process TAS11839751
    GO:0008285negative regulation of cell proliferation IMP12704195

    ALOX15B for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    ALOX15B for compounds           About GeneDecksing

    EMD Millipore small molecules for ALOX15B:
    Small Molecule - inhibitor
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ALOX15B (LX15B)

    7 HMDB Compounds for ALOX15B    About this table
    CompoundSynonyms CAS #PubMed Ids
    13-L-Hydroperoxylinoleic acid(13S,9z,11e)-13-hydroperoxy-9,11-octadecadienoic acid (see all 18)33964-75-9--
    15(S)-HPETE(5Z,8Z,11Z,13E)-(15S)-15-Hydroperoxyicosa-5,8,11,13-tetraenoate (see all 8)70981-96-3--
    8(S)-HPETE8S-hydoperoxy-5Z,9E,11Z,14Z-eicosatetraenoic acid (see all 3)----
    Arachidonic acid5,8,11,14-Eicosatetraenoic acid (see all 16)506-32-1--
    IronArmco iron (see all 19)7439-89-6--
    Linoleic acid(9Z,12Z)-9,12-Octadecadienoate (see all 26)60-33-3--
    OxygenOxygen (see all 5)7782-44-7--

    7 Novoseek inferred chemical compound relationships for ALOX15B gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    15-hydroxyeicosatetraenoic acid 88.3 7 11571629 (3), 11442747 (1), 15533897 (1), 18202670 (1)
    arachidonic acid 74.1 20 9177185 (2), 12727848 (1), 12704195 (1), 11212240 (1) (see all 13)
    ns 398 59.8 3 12659684 (1), 16874012 (1)
    linoleic acid 54.5 2 9177185 (1), 16566819 (1)
    phorbol 48.7 1 10625675 (1)
    paraffin 12 2 11014584 (1)
    steroid 0 1 16682954 (1)

    Search CenterWatch for drugs/clinical trials and news about ALOX15B / LX15B

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for ALOX15B gene (3 alternative transcripts): 
    NM_001039130.1  NM_001039131.1  NM_001141.2  

    Unigene Cluster for ALOX15B:

    Arachidonate 15-lipoxygenase, type B
    Hs.111256  [show with all ESTs]
    Unigene Representative Sequence: BC033294
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000380183(uc002gju.3 uc002gjv.3 uc002gjw.3 uc010vun.2)
    ENST00000572022 ENST00000571240(uc010cnp.3) ENST00000573359 ENST00000380173

    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ALOX15B
    5 QIAGEN miScript miRNA Assays for microRNAs that regulate ALOX15B:
    hsa-miR-2052 hsa-miR-330-5p hsa-miR-326 hsa-miR-26b* hsa-miR-323b-5p
    SwitchGear 3'UTR luciferase reporter plasmidALOX15B 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for ALOX15B
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ALOX15B
    Clone
    Products:
         
    OriGene clones in human, mouse for ALOX15B (see all 15)
    OriGene ORF clones in mouse, rat for ALOX15B
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 3): ALOX15B (NM_001141)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ALOX15B
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ALOX15B
    Sirion Biotech Customized lentivirus for stable overexpression of ALOX15B 
                         Customized lentivirus expression plasmids for stable overexpression of ALOX15B 
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for ALOX15B
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat ALOX15B
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ALOX15B
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ALOX15B

    Additional mRNA sequence: 

    AF468051.1 AF468052.1 AF468053.1 AF468054.1 AK292779.1 AK298095.1 AK300554.1 BC033294.1 
    BC035217.1 BC063647.1 U78294.1 

    7 DOTS entries:

    DT.108481  DT.101981385  DT.97790313  DT.97836298  DT.102822610  DT.92419921  DT.99958412 

    24/63 AceView cDNA sequences (see all 63):

    AI474406 AI829771 AI695749 AI817643 BG740579 CA307212 BG739709 CB051073 
    BG741964 BG742611 U78294 BG698185 BG743633 AI420751 AW294456 BG674800 
    BG696804 BC063647 BI489877 AF468052 BV174905 AF468054 BC033294 BG696031 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for ALOX15B    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12a · 12b ^ 13 ^ 14a · 14b
    SP1:                          -                                                                 -                           
    SP2:                          -                                         -                       -                           
    SP3:                          -                                         -           -     -     -                           
    SP4:                                                                                                                        
    SP5:                                                                                                                        


    ECgene alternative splicing isoforms for ALOX15B

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ALOX15B expression in normal human tissues (normalized intensities)      ALOX15B embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CCCATAATCC
    ALOX15B Expression
    About this image


    ALOX15B expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/4 selected tissues (see all 4) fully expand
     
     Prostate (Endocrine System)    fully expand to see all 2 entries
             Human Prostate Epithelial Cells (HPrEpiC)   
             prostate gland   
     
     Epithelium
             Human Prostate Epithelial Cells (HPrEpiC)   
     
     Breast (Uncategorized)
             Human Mammary Epithelial Cells (HMEpiC)   
     
     Bone (Muscoskeletal System)
             HyStem+BMP4-induced MEL2 cells

     -- (Integumentary System)
             SKIN   

    See ALOX15B Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ALOX15B

    SOURCE GeneReport for Unigene cluster: Hs.111256

    UniProtKB/Swiss-Prot: LX15B_HUMAN, O15296
    Tissue specificity: Expressed in hair, prostate, lung and cornea

        SABiosciences Expression via Pathway-Focused PCR Array including ALOX15B: 
              Apoptosis 384HT in human mouse rat

    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for ALOX15B
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat ALOX15B
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ALOX15B
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ALOX15B
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ALOX15B

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for ALOX15B gene from 4/10 species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Alox81 , 5 arachidonate 8-lipoxygenase1, 5 80.33(n)1
    78.11(a)1
      11 (42.38 cM)5
    116881  NM_009661.31  NP_033791.11 
     691839325 
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    (see all 6)
    --
    53(a)
    51(a)
    (see all 6)
    many ↔ many
    possible ortholog
    (see all 6)
    GL343400.1(684955-695029)
    GL343400.1(726949-745560)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.252382 Xenopus laevis transcribed sequence with weak similarity more 73.98(n)    BJ627300.1 
    zebrafish
    (Danio rerio)
    Actinopterygii zgc:1528916
    ALOX15B6
    arachidonate 15-lipoxygenase, type B
    40(a)
    37(a)
    possible ortholog
    1 ↔ many
    21(29958222-29989099)
    21(24924940-24935413)


    ENSEMBL Gene Tree for ALOX15B (if available)
    TreeFam Gene Tree for ALOX15B (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ALOX15B gene
    ALOX12B2  ALOX52  ALOXE32  ALOX152  ALOX122  
    6 SIMAP similar genes for ALOX15B using alignment to 2 protein entries:     LX15B_HUMAN (see all proteins):
    arachidonate 12-lipoxygenase    ALOX12B    ALOXE3    ALOX5    ALOX15    ALOX12

    ALOX15B for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for ALOX15B
    PGOHUM00000262362


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/442 SNPs in ALOX15B are shown (see all 442)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1920799231,2
    --7929339(+) TCACTA/GCAACC 3 -- us2k10--------
    rs1842988201,2
    --7929362(+) GTTCAA/GGTGAT 3 -- us2k10--------
    rs1418647271,2
    --7929389(+) CCTGAA/GTAGCT 3 -- us2k10--------
    rs1117829661,2
    F--7929456(+) GTAGCC/TGGAAT 3 -- us2k11Minor allele frequency- T:0.50CSA 2
    rs1881326141,2
    --7929561(+) TCGTGA/TTCTGC 3 -- us2k10--------
    rs1484620441,2
    --7929586(+) CAAAGC/TTCTGA 3 -- us2k10--------
    rs1924074491,2
    C--7929623(+) GACCAA/TGATCT 3 -- us2k10--------
    rs46005161,2
    C,F,A--7929636(+) TTCTTC/TTTCAT 3 -- us2k17Minor allele frequency- T:0.48WA NA CSA EA 365
    rs44686901,2
    C,F,A,H--7929728(+) ACAGGC/TACAAG 3 -- us2k130Minor allele frequency- T:0.19NS EA NA MN CSA WA 3173
    rs728415011,2
    C,F--7929751(+) CTGCCG/AGCATC 3 -- us2k12Minor allele frequency- A:0.05NA EA 240

    HapMap Linkage Disequilibrium report for ALOX15B (7942335 - 7952452 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for ALOX15B:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv833352CNV Loss17160897
    nsv528325CNV Loss19592680

    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing ALOX15B
    DNA2.0 Custom Variant and Variant Library Synthesis for ALOX15B

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 603697    OMIM disorders: --

    20/24 diseases for ALOX15B (see all 24):    About MalaCards
    autosomal recessive congenital ichthyosis    prostate adenocarcinoma    congenital ichthyosiform erythroderma    prostate cancer, progression of
    ichthyosis    esophageal cancer    narcolepsy    prostate cancer
    hypoxia    prostatitis    meningioma    inflammatory bowel disease
    adenocarcinoma    psoriasis    ovarian cancer    esophagitis
    asthma    retinitis    colorectal cancer    lung cancer


    ALOX15B for disorders           About GeneDecksing

    10/13 Novoseek inferred disease relationships for ALOX15B gene (see all 13)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    prostate carcinoma 55 9 11014584 (2), 11212240 (1), 15257547 (1), 12189136 (1) (see all 5)
    prostatic adenocarcinoma 52.7 9 10393855 (4), 11014584 (1), 11442747 (1)
    prostatic intraepithelial neoplasia 44.9 1 11014584 (1)
    prostate cancer 41.9 18 11839751 (5), 20428779 (2), 12189136 (2), 12085962 (1) (see all 7)
    hnscc 38.1 2 16874012 (1)
    tumors 27.5 55 11014584 (7), 12704195 (3), 15257547 (3), 15799828 (3) (see all 13)
    premalignant 23.8 1 12659684 (1)
    carcinoma squamous cell 14.3 3 16581564 (1), 16874012 (1)
    carcinoma 14 10 16874012 (5), 16581564 (1), 15257547 (1), 11442747 (1)
    inflammation 4.7 1 19912316 (1)

    Genetic Association Database (GAD): ALOX15B
    Human Genome Epidemiology (HuGE) Navigator: ALOX15B (7 documents)

    Export disorders for ALOX15B gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ALOX15B gene, integrated from 9 sources (see all 81):
    (articles sorted by number of sources associating them with ALOX15B)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Discovery of a second 15S-lipoxygenase in humans. (PubMed id 9177185)1, 2, 3, 9 Brash A.R.... Chang M.S. (1997)
    2. Evidence that arachidonate 15-lipoxygenase 2 is a negative cell cycle regulator in normal prostate epithelial cells. (PubMed id 11839751)1, 2, 9 Tang S.... Tang D.G. (2002)
    3. A gene cluster encoding human epidermis-type lipoxygenases at chromosome 17p13.1: cloning, physical mapping, and expression. (PubMed id 11350124)1, 2, 9 Krieg P.... Fuerstenberger G. (2001)
    4. Differential characteristics of human 15-lipoxygenase isozymes and a novel splice variant of 15S-lipoxygenase. (PubMed id 10542053)1, 2, 9 Kilty I.... Vickers P.J. (1999)
    5. Risk of meningioma and common variation in genes rela ted to innate immunity. (PubMed id 20406964)1, 4 Rajaraman P....Inskip P.D. (2010)
    6. Polymorphisms in innate immunity genes and risk of ch ildhood leukemia. (PubMed id 20438785)1, 4 Han S....Kang D. (2010)
    7. An approach based on a genome-wide association study reveals candidate loci for narcolepsy. (PubMed id 20677014)1, 4 Shimada M....Tokunaga K. (2010)
    8. Polymorphism in the IL18 gene and epithelial ovarian cancer in non-Hispanic white women. (PubMed id 19064572)1, 4 Palmieri R.T.... . (2008)
    9. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    10. Subcellular localization and tumor-suppressive functions of 15-lipoxygenase 2 (15-LOX2) and its splice variants. (PubMed id 12704195)1, 9 Bhatia B....Tang D.G. (2003)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 247 HGNC: 434 AceView: ALOX15B Ensembl:ENSG00000179593 euGenes: HUgn247
    ECgene: ALOX15B Kegg: 247 H-InvDB: ALOX15B

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ALOX15B Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for ALOX15B gene:
    Search GeneIP for patents involving ALOX15B

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     Browse Purified and Recombinant Proteins at EMD Millipore
     Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
     EMD Millipore small molecules (inhibitor) for ALOX15B
     Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
     Browse for Gene Knock-down Tools from EMD Millipore
     Browse Kits and Assays available from EMD Millipore
     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Protease Activity Assays and Reagents   Browse Recombinant/Natural Proteins  
     Browse Stem Cell Products   Browse Tocris Biochemicals & Compounds  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for ALOX15B  
     Browse OriGene qPCR primer pairs and template standards   OriGene Protein Over-expression Lysate for ALOX15B  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for ALOX15B  
     OriGene qSTAR qPCR primer pairs in human, mouse for ALOX15B   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for ALOX15B   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for ALOX15B   OriGene Custom Protein Services for ALOX15B  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat ALOX15B
     QIAGEN SeqTarget long-range PCR primers for resequencing ALOX15B
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ALOX15B
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ALOX15B
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ALOX15B
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ALOX15B
     GenScript Custom Purified and Recombinant Proteins Services for ALOX15B GenScript cDNA clones with any tag delivered in your preferred vector for ALOX15B
     GenScript Custom Assay Services for ALOX15B GenScript Custom Superior Antibodies Services for ALOX15B
     GenScript Custom overexpressing Cell Line Services for ALOX15B CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in ALOX15B promoter
     Search Chromatin IP Primers for ALOX15B
     RT2 qPCR Primer Assay in human, mouse, rat ALOX15B
     GNC Network for ALOX15B
     SABiosciences PCR Arrays including human, mouse, rat ALOX15B
     Search Tocris compounds for ALOX15B (LX15B)
     Proteins and Antibodies for ALOX15B
     Cell Lysates for ALOX15B
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     ALOX15B antibodies
     ALOX15B proteins
     ALOX15B lysates
     Antibodies for ALOX15B
     See all of Abcam's Antibodies, Kits and Proteins for ALOX15B
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     Proteins for ALOX15B
     Antibodies for ALOX15B
     ELISAs for ALOX15B
     CLIAs for ALOX15B
     Search LifeMap BioReagents cell lines for ALOX15B
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ALOX15B
     SwitchGear 3'UTR luciferase reporter plasmids for ALOX15B
     SwitchGear Promoter luciferase reporter plasmids for ALOX15B
     ThermoFisher Antibodies for ALOX15B
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ALOX15B
     inGenious Targeting Laboratory - Custom generated mouse model solutions for ALOX15B
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for ALOX15B
    Customized:
     lentivirus for stable overexpression of ALOX15B
     lentivirus expression plasmids for stable overexpression of ALOX15B
     adenovirus for overexpression of ALOX15B
     LSBio Antibodies in human, mouse, rat for ALOX15B
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

    View Random Gene

    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      ALOX15B gene at Home site.
    hostname: 356977-web1.xennexinc.com index build: 106 solr: 1.4