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ALOX15B Gene

protein-coding GIFtS: 57

GC17P007883

arachidonate 15-lipoxygenase, type B
(Previous names: arachidonate 15-lipoxygenase, second type )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
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Aliases
15-LOX-2 ^¹, ², ³
15S-lipoxygenase ^²
EC 1.13.11.33 ^³
OTTHUMP00000135321 ^²

Descriptions
15-lipoxygenase 2 ^³
arachidonate 15-lipoxygenase 2 ^²
arachidonate 15-lipoxygenase, second type ^¹, ²
arachidonate 15-lipoxygenase, type B ^²
arachidonate omega(6) lipoxygenase ^²

External Ids
HGNC: 434¹
Entrez Gene: 247²
UniProtKB: O15296³
Ensembl: ENSG00000179593⁷

Search outside databases for aliases for ALOX15B gene

Previous GC identifers: GC17P008408 GC17P008813 GC17P007884 GC17P008142

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for ALOX15B:

This gene encodes a member of the lipoxygenase family of structurally related nonheme iron

dioxygenases involved in the production of fatty acid hydroperoxides. The encoded protein converts

arachidonic acid exclusively to 15S-hydroperoxyeicosatetraenoic acid, while metabolizing linoleic

acid less effectively. This gene is located in a cluster of related genes and a pseudogene that

spans approximately 100 kilobases on the short arm of chromosome 17. Alternatively spliced

transcript variants encoding different isoforms have been described. [provided by RefSeq]

UniProtKB/Swiss-Prot: LX15B_HUMAN, O15296

Function: Converts arachidonic acid exclusively to 15S-hydroperoxyeicosatetraenoic acid, while

linoleic acid is less well metabolized

Gene Wiki entry for ALOX15B

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the ALOX15B gene

Entrez Gene cytogenetic band: 17p13.1 Ensembl cytogenetic band: 17p13.1 HGNC cytogenetic band: 17p13.1

ALOX15B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 17 GeneLoc Exon Structure

GeneLoc location for GC17P007883: (about GC identifiers)

Start:	7,883,083 bp from pter
End:	7,893,177 bp from pter
Size:	10,095 bases
Orientation:	plus strand

RefSeq DNA sequence:

NC_000017.9 NT_010718.15

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: LX15B_HUMAN, O15296 (See protein sequence)

Recommended Name: Arachidonate 15-lipoxygenase type II

Size: 676 amino acids; 75885 Da

Cofactor: Binds 1 iron ion per subunit (By similarity)

Subcellular location: Cytoplasm (By similarity)

Secondary accessions: Q8IYQ2 Q8TEV3 Q8TEV4 Q8TEV5 Q8TEV6 Q9UKM4

Alternative splicing: 4 isoforms: O15296-1 O15296-2 O15296-3 O15296-4

REFSEQ proteins (3 alternative transcripts):

NP_001034219.1 NP_001034220.1 NP_001132.2

ENSEMBL proteins:

ENSP00000369520 ENSP00000369530 ENSP00000344337

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Enzo Life Sciences proteins for ALOX15B
	Recombinant Proteins from Abcam (15 Lipoxygenase 2)
	Human Recombinant Proteins from Abnova (ALOX15B)

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

2 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005622	intracellular	ISS	--
GO:0005737	cytoplasm	IEA	--

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Antibodies for ALOX15B:

	Browse Antibodies Central at Invitrogen
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Sigma-Aldrich Antibodies for ALOX15B
	Browse R&D Systems for Antibodies
	Antibodies from Abcam (15 Lipoxygenase 2), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (ALOX15B)
	Novus Biologicals Antibody for ALOX15B

Assays for ALOX15B:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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Graphical View of Domain Structure for InterPro Entry O15296

ProtoNet protein and cluster: O15296

3 Blocks protein families:

IPB000907 Lipoxygenase

IPB001024 Lipoxygenase

IPB001885 Mammalian lipoxygenase signature

UniProtKB/Swiss-Prot: LX15B_HUMAN, O15296

Similarity: Belongs to the lipoxygenase family

Similarity: Contains 1 lipoxygenase domain

Similarity: Contains 1 PLAT domain

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (ALOX15B)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (ALOX15B)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 3): NM_001039130

Applied Biosystems Silencer® siRNAs for ALOX15B

Sigma-Aldrich siRNA and siRNA Panels for ALOX15B

Sigma-Aldrich shRNA Panels and shRNA for ALOX15B

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for ALOX15B
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clones in CMV expression vector (see all 3): NM_001039130
Myc/DDK tagged cDNA clones in CMV expression vector (see all 3): NM_001039130
untagged cDNA clones in CMV expression vector (see all 3): NM_001039130

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_001141

UniProtKB/Swiss-Prot: LX15B_HUMAN, O15296

Function: Converts arachidonic acid exclusively to 15S-hydroperoxyeicosatetraenoic acid, while

linoleic acid is less well metabolized

Catalytic activity: Arachidonate + O(2) =

(5Z,8Z,11Z,13E)-(15S)-15-hydroperoxyicosa-5,8,11,13-tetraenoate

Enzyme Number (IUBMB): EC 1.13.11.33

5 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005506	iron ion binding	IEA	--
GO:0016165	lipoxygenase activity	TAS	9177185
GO:0016491	oxidoreductase activity	IEA	--
GO:0046872	metal ion binding	IEA	--
GO:0050473	arachidonate 15-lipoxygenase activity	ISS	--

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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3 Sigma-Aldrich "Your Favorite Gene" Pathways for ALOX15B (Your Favorite Gene powered by Ingenuity)

Linoleic Acid Metabolism
Eicosanoid Signaling
Arachidonic Acid Metabolism

GeneDecks ALOX15B for the pathways selected above

About GeneDecksing

UniProtKB/Swiss-Prot: LX15B_HUMAN, O15296

Pathway: Lipid metabolism; leukotriene D4 biosynthesis

Gene Network Central^TM Interacting Genes and Proteins Network for ALOX15B

5/11 Gene Ontology (GO) biological process terms (links to tree view) (see all 11 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006629	lipid metabolic process	TAS	11839751
GO:0006631	fatty acid metabolic process	TAS	9177185
GO:0006917	induction of apoptosis	TAS	11839751
GO:0008285	negative regulation of cell proliferation	ISS	--
GO:0019370	leukotriene biosynthetic process	IEA	--

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Enzo Life Sciences drugs & compounds for ALOX15B

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for ALOX15B
5 Novoseek chemical compound relationships for ALOX15B gene

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
15-hydroxyeicosatetraenoic acid	87.59	7	11571629 (3), 11442747 (1), 15533897 (1), 18202670 (1)
arachidonic acid	74.70	19	9177185 (2), 12727848 (1), 12704195 (1), 11212240 (1) (see all 12)
linoleic acid	56.53	2	9177185 (1), 16566819 (1)
phorbol	50.23	1	10625675 (1)
steroid	0.00	1	16682954 (1)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (ALOX15B)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (ALOX15B)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 3): NM_001039130

Sigma-Aldrich siRNA and siRNA Panels for ALOX15B

Sigma-Aldrich shRNA Panels and shRNA for ALOX15B

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_001039130 NM_001039131 NM_001141

REFSEQ mRNAs for ALOX15B gene (3 alternative transcripts):

NM_001039130.1 NM_001039131.1 NM_001141.2

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_001039130 NM_001039131 NM_001141

               OriGene GFP tagged cDNA clones in CMV expression vector (see all 3): NM_001039130
                                 Myc/DDK tagged cDNA clones in CMV expression vector (see all 3): NM_001039130
                                 untagged cDNA clones in CMV expression vector (see all 3): NM_001039130

Additional cDNA sequence:

AF468051.1 AF468052.1 AF468053.1 AF468054.1 AK292779.1 AK298095.1 AK300554.1 BC033294.1

BC035217.1 BC063647.1 U78294.1

7 DOTS entries:

DT.108481 DT.101981385 DT.97790313 DT.97836298 DT.102822610 DT.92419921 DT.99958412

24/63 AceView cDNA sequences (see all 63 ):

CB051073 BG739709 AI474406 AI695749 AI817643 AI829771 BG740579 CA307212

BG675395 CA405703 AW294456 BX106451 BG740763 BC063647 BG741964 BG698185

BG697910 BG696031 BC033294 BG675344 AF468051 BG739941 BX343731 BG696804

highest scoring ESTs for ALOX15B:

U78294 AA228916 AA229624 AA468451 AA470333 AA595521 AF468051 AF468052 AF468053 AF468054

Unigene Cluster for ALOX15B:

Arachidonate 15-lipoxygenase, type B

Hs.111256 [show with all ESTs]

Unigene Representative Sequence: BC033294

GeneLoc Exon Structure

5 Alternative Splicing Database (ASD) splice patterns (SP) for ALOX15B

ExUns:	1a	·	1b	^	2	^	3	^	4a	·	4b	^	5	^	6a	·	6b	^	7	^	8	^	9	^	10a	·	10b	^	11	^	12a	·	12b	^	13	^	14a	·	14b
SP1:									-																						-
SP2:									-														-								-
SP3:									-														-				-		-		-
SP4:
SP5:

About this scheme

ECgene alternative splicing isoforms for ALOX15B

3 Ensembl transcripts including schematic representations:

ENST00000380173 ENST00000380183 ENST00000339694

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

ALOX15B expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for ALOX15B

¹ / ² / ³

4 probe-sets matching ALOX15B gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
37430_at²^{, 3}	U95-A	1	1.00	1.00	1.00	1.00	U78294	1.00	1.00	1.00	1
206714_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_001141	0.60	1.00	0.82	1
1555416_a_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
206714_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

GeneDecks ALOX15B for binary patterns associated with the probe-sets selected above

About GeneDecksing

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Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: CCCATAATCC

SOURCE GeneReport for Unigene cluster: Hs.111256
Expression variation in blood from EXPOLDB for ALOX15B
UniProtKB/Swiss-Prot: LX15B_HUMAN, O15296
Tissue specificity: Expressed in hair, prostate, lung and cornea

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for ALOX15B gene from 5/6 species (see all 6 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	ALOX15B¹	--	arachidonate 15-lipoxygenase, type B	84.32(n) 81.36(a)	489485 XM_546603.1 XP_546603.1
chimpanzee (Pan troglodytes)	ALOX15B¹	--	arachidonate 15-lipoxygenase, type B	99.06(n) 98.67(a)	455104 XM_511865.2 XP_511865.2
cow (Bos taurus)	ALOX15B¹	--	arachidonate 15-lipoxygenase, type B	85.4(n) 82.99(a)	286820 XM_588924.3 XP_588924.3
rat (Rattus norvegicus)	Alox15b¹	--	arachidonate 15-lipoxygenase, type B	81.41(n) 80.77(a)	266604 NM_153301.1 NP_695213.1
mouse (Mus musculus)	Alox8^{1, 5}	11⁵	arachidonate 8-lipoxygenase^{1, 5}	80.33(n)¹ 78.11(a)¹	11688¹ NM_009661.3¹ NP_033791.1¹ AF250379⁵ AK028724⁵ (see all 10)

About this table Species with no ortholog for ALOX15B

ENSEMBL Gene Tree for ALOX15B

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for ALOX15B gene

ALOX12P2² ALOX15² ALOX12²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/96 NCBI SNPs in ALOX15B are shown (see all 96 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 54)

AB	SNP ID	Valid	Chr 17 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--				--
	rs7225107^1,2	A,C,F,H	7892603(+)	`TCTCCA/GTCTAA`	3	I/V	mis¹ ese³		12		EU EA WA NA	1054
	rs4792147^1,2	A,C,F,H	7892544(+)	`GAACCG/AGGGCC`	3	R/Q	mis¹		11		NA EU EA WA	932
	rs4468690^1,2	A,C,F,H	7881479(+)	`ACAGGC/TACAAG`	3	--	ng5¹		8		EU EA WA	838
	rs12602213^1,2	A,C,F,H	7881619(+)	`cttatA/Gggata`	3	--	ng5¹		12		EU EA WA	1256
--	rs7211321^1,2	A,C,F	7893660(+)	`aaaaTG/ACCCAA`	3	--	ng3¹		3		NA	136
--	rs8075588^1,2	A,C	7882662(+)	`gaatcA/Gcttga`	3	--	ng5¹ tfbs³		0	--	--	--	--
--	rs9913975^1,2	A,C	7893192(+)	`gtggtA/Gtgtgg`	3	--	ng3¹		0	--	--	--	--
--	rs7211013^1,2	A	7893484(+)	`aaaaaA/Ttagct`	3	--	ng3¹		0	--	--	--	--
--	rs9911942^1,2	H	7893405(+)	`aggtaG/Aaggga`	3	--	ng3¹		4		EU EA WA	404
--	rs4600516^1,2	A	7881387(+)	`TTCTTC/TTTCAT`	3	--	ng5¹		0	--	--	--	--

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HapMap Linkage Disequilibrium images for ALOX15B (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 603697

10/12 Novoseek disease relationships for ALOX15B gene (see all 12 )

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
prostate carcinoma	56.83	9	11014584 (2), 11212240 (1), 15257547 (1), 12189136 (1) (see all 5)
prostatic adenocarcinoma	54.71	9	10393855 (4), 11014584 (1), 11442747 (1)
prostatic intraepithelial neoplasia	46.99	1	11014584 (1)
hnscc	41.44	2	16874012 (1)
prostate cancer	35.65	15	11839751 (5), 12189136 (2), 12085962 (1), 17164141 (1) (see all 6)
premalignant	26.37	1	12659684 (1)
tumors	25.90	54	11014584 (7), 12704195 (3), 15257547 (3), 15799828 (3) (see all 12)
carcinoma squamous cell	17.19	3	16581564 (1), 16874012 (1)
carcinoma	16.61	10	16874012 (5), 16581564 (1), 15257547 (1), 11442747 (1)
cancer	0.00	8	12659684 (3), 15799828 (2), 12189136 (1), 16682954 (1)

About this table

Human Genome Epidemiology Navigator: ALOX15B (1 document)

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/61 PubMed articles for ALOX15B gene (see all 61 ):

Discovery of a second 15S-lipoxygenase in humans. (PubMed id 9177185)^{1, 2, 3, 4} Brash A.R.... Chang M.S. (1997)
Evidence that arachidonate 15-lipoxygenase 2 is a negative cell cycle regulator in normal prostate epithelial cells. (PubMed id 11839751)^{1, 3, 4} Tang S.... Tang D.G. (2002)
A gene cluster encoding human epidermis-type lipoxygenases at chromosome 17p13.1: cloning, physical mapping, and expression. (PubMed id 11350124)^{1, 3, 4} Krieg P.... Fuerstenberger G. (2001)
Differential characteristics of human 15-lipoxygenase isozymes and a novel splice variant of 15S-lipoxygenase. (PubMed id 10542053)^{1, 3, 4} Kilty I.... Vickers P.J. (1999)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)
Subcellular localization and tumor-suppressive functions of 15-lipoxygenase 2 (15-LOX2) and its splice variants. (PubMed id 12704195)^{1, 3} Bhatia B....Tang D.G. (2003)
Reduction of isoforms of 15-lipoxygenase (15-LOX)-1 and 15-LOX-2 in human breast cancer. (PubMed id 16556493)^{1, 3} Jiang W.G....Mansel R.E. (2006)
Evidence that Sp1 positively and Sp3 negatively regulate and androgen does not directly regulate functional tumor suppressor 15-lipoxygenase 2 (15-LOX2) gene expression in normal human prostate epithelial cells. (PubMed id 15247906)^{1, 3} Tang S....Tang D.G. (2004)
15-Lipoxygenase-2 gene regulation by its product 15-(S)-hydroxyeicosatetraenoic acid through a negative feedback mechanism that involves peroxisome proliferator-activated receptor gamma. (PubMed id 16682954)^{1, 3} Subbarayan V....Menter D.G. (2006)
Inverse relationship between 15-lipoxygenase-2 and PPAR-gamma gene expression in normal epithelia compared with tumor epithelia. (PubMed id 15799828)^{1, 3} Subbarayan V....Menter D.G. (2005)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 247	HGNC: 434	AceView: ALOX15B	Ensembl:ENSG00000179593	euGenes: HUgn247
ECgene: ALOX15B	H-InvDB: ALOX15B

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Licensable Technologies for ALOX15B
(Available from WIS Yeda, Salk, Tufts)

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(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for ALOX15B:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for ALOX15B-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for ALOX15B		Antibodies for ALOX15B
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for ALOX15B		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Recombinant Proteins (ALOX15B)
	Antibodies (ALOX15B)
	Chimera RNAi (ALOX15B)
	Custom Service for Mouse Mab
	Custom Service for Rabbit Pab from Full-length Protein

Search for Antibodies & Assays

	Recombinant Proteins (15 Lipoxygenase 2)
	Antibodies (15 Lipoxygenase 2)

Search OriGene for ALOX15B

Search Tocris compounds for ALOX15B

	Drugs/Proteins for ALOX15B
	Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Antibodies for ALOX15B

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Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

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The GeneCards Human Gene Database: Copyright © 1996-2009, Weizmann Institute of Science. All Rights Reserved.
ALOX15B Gene at Home site.
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ALOX15B Gene

protein-coding GIFtS: 57

Aliases &
Descriptions
for ALOX15B

Summaries
for ALOX15B

Genomic Location
for ALOX15B

Proteins
for ALOX15B

Protein Domains/
Families
for ALOX15B

Gene Function
for ALOX15B

Pathways & Interactions
for ALOX15B

Drugs & Compounds
for ALOX15B

Transcripts
for ALOX15B

Expression
for ALOX15B

Orthologs
for ALOX15B

Paralogs
for ALOX15B

SNPs/Variants
for ALOX15B

Disorders & Mutations
for ALOX15B

Medical News
for ALOX15B

Publications
for ALOX15B

Search for ALOX15B

Genome Databases showing ALOX15B

Other Databases showing ALOX15B

Specialized Databases showing ALOX15B

Licensable Technologies
for ALOX15B

Services
for ALOX15B

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

ALOX15B Gene

protein-coding GIFtS: 57

Aliases & Descriptionsfor ALOX15B

Summariesfor ALOX15B

Genomic Locationfor ALOX15B

Proteinsfor ALOX15B

Protein Domains/Familiesfor ALOX15B

Gene Functionfor ALOX15B

Pathways & Interactionsfor ALOX15B

Drugs & Compoundsfor ALOX15B

Transcriptsfor ALOX15B

Expression for ALOX15B

Orthologsfor ALOX15B

Paralogsfor ALOX15B

SNPs/Variantsfor ALOX15B

Disorders & Mutationsfor ALOX15B

Medical Newsfor ALOX15B

Publicationsfor ALOX15B

Search for ALOX15B

Genome Databases showing ALOX15B

Other Databases showing ALOX15B

Specialized Databases showing ALOX15B

Licensable Technologiesfor ALOX15B

Servicesfor ALOX15B

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for ALOX15B

Summaries
for ALOX15B

Genomic Location
for ALOX15B

Proteins
for ALOX15B

Protein Domains/
Families
for ALOX15B

Gene Function
for ALOX15B

Pathways & Interactions
for ALOX15B

Drugs & Compounds
for ALOX15B

Transcripts
for ALOX15B

Expression
for ALOX15B

Orthologs
for ALOX15B

Paralogs
for ALOX15B

SNPs/Variants
for ALOX15B

Disorders & Mutations
for ALOX15B

Medical News
for ALOX15B

Publications
for ALOX15B

Licensable Technologies
for ALOX15B

Services
for ALOX15B