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ALOX15B Gene

protein-coding   GIFtS: 61
GCID: GC17P007942

Arachidonate 15-Lipoxygenase, Type B

(Previous names: arachidonate 15-lipoxygenase, second type)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Arachidonate 15-Lipoxygenase, Type B1 2     15S-lipoxygenase2
Arachidonate 15-Lipoxygenase, Second Type1 2     Arachidonate 15-Lipoxygenase 22
Arachidonate 15-Lipoxygenase Type II2 3     Arachidonate 15-Lipoxygenase B2
Linoleate 13-Lipoxygenase 15-LOb2 3     Arachidonate Omega(6) Lipoxygenase2
15-LOX-22 3     15-Lipoxygenase 23
15-LOX-B2 3     EC 1.13.11.-3
EC 1.13.11.333 8     EC 1.13.118

External Ids:    HGNC: 4341   Entrez Gene: 2472   Ensembl: ENSG000001795937   OMIM: 6036975   UniProtKB: O152963   

Export aliases for ALOX15B gene to outside databases

Previous GC identifers: GC17P008408 GC17P008813 GC17P007884 GC17P008142 GC17P007883


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for ALOX15B Gene:
This gene encodes a member of the lipoxygenase family of structurally related nonheme iron dioxygenases involved
in the production of fatty acid hydroperoxides. The encoded protein converts arachidonic acid exclusively to
15S-hydroperoxyeicosatetraenoic acid, while metabolizing linoleic acid less effectively. This gene is located in
a cluster of related genes and a pseudogene that spans approximately 100 kilobases on the short arm of chromosome
17. Alternatively spliced transcript variants encoding different isoforms have been described. (provided by
RefSeq, Jul 2008)

GeneCards Summary for ALOX15B Gene:
ALOX15B (arachidonate 15-lipoxygenase, type B) is a protein-coding gene. Diseases associated with ALOX15B include prostate adenocarcinoma, and autosomal recessive congenital ichthyosis. GO annotations related to this gene include iron ion binding and linoleate 13S-lipoxygenase activity. An important paralog of this gene is ALOX12B.

UniProtKB/Swiss-Prot: LX15B_HUMAN, O15296
Function: Non-heme iron-containing dioxygenase that catalyzes the stereo-specific peroxidation of free and
esterified polyunsaturated fatty acids generating a spectrum of bioactive lipid mediators. Converts arachidonic
acid to 15S-hydroperoxyeicosatetraenoic acid/(15S)-HPETE. Also acts on linoleic acid to produce
13-hydroxyoctadecadienoic acid/13-HPODE. Has no detectable 8S-lipoxygenase activity but reacts with (8S)-HPETE to
produce (8S,15S)-diHPETE. May regulate progression through the cell cycle and cell proliferation. May also
regulate cytokine secretion by macrophages and therefore play a role in the immune response. May also regulate
macrophages differentiation into proatherogenic foam cells

Gene Wiki entry for ALOX15B Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000017.11  NC_018928.2  NT_010718.17  
Regulatory elements:
   Regulatory transcription factor binding sites in the ALOX15B gene promoter:
         CREB   GR   AhR   PPAR-gamma1   POU3F1   GR-beta   SEF-1 (1)   GR-alpha   LCR-F1   RORalpha2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidALOX15B promoter sequence
   Search Chromatin IP Primers for ALOX15B

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ALOX15B


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17p13.1   Ensembl cytogenetic band:  17p13.1   HGNC cytogenetic band: 17p13.1

ALOX15B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ALOX15B gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17P007942:  view genomic region     (about GC identifiers)

Start:
7,942,335 bp from pter      End:
7,952,452 bp from pter
Size:
10,118 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: LX15B_HUMAN, O15296 (See protein sequence)
Recommended Name: Arachidonate 15-lipoxygenase B  
Size: 676 amino acids; 75857 Da
Cofactor: Binds 1 iron ion per subunit (By similarity)
Caution: Despite its homology with mouse Alox8 (AC O35936), it seems not to have any 8S-lipoxygenase activity on
arachidonate
Sequence caution: Sequence=AAD37786.1; Type=Erroneous gene model prediction;
Secondary accessions: D3DTR2 Q8IYQ2 Q8TEV3 Q8TEV4 Q8TEV5 Q8TEV6 Q9UKM4
Alternative splicing: 4 isoforms:  O15296-1   O15296-2   O15296-3   O15296-4   

Explore the universe of human proteins at neXtProt for ALOX15B: NX_O15296

Explore proteomics data for ALOX15B at MOPED

3 DME Specific Peptides for ALOX15B (O15296)
 NPVLIRRC  YPDEHFTE  TCSAKHAAV 


See ALOX15B Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins (3 alternative transcripts): 
NP_001034219.1  NP_001034220.1  NP_001132.2  

ENSEMBL proteins: 
 ENSP00000369530   ENSP00000458749   ENSP00000460332   ENSP00000369520  
Reactome Protein details: O15296

ALOX15B Human Recombinant Protein Products:

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Cloud-Clone Corp. CLIAs for ALOX15B


(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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HGNC Gene Families:
ALOX: Arachidonate lipoxygenases

IUPHAR Guide to PHARMACOLOGY protein family classification: 15-LOX-2
Lipoxygenases

Selected InterPro protein domains (see all 7):
 IPR020833 LipOase_Fe_BS
 IPR013819 LipOase_C
 IPR001024 PLAT/LH2_dom
 IPR008976 Lipase_LipOase
 IPR020834 LipOase_CS

Graphical View of Domain Structure for InterPro Entry O15296

ProtoNet protein and cluster: O15296

3 Blocks protein domains:
IPB000907 Lipoxygenase
IPB001024 Lipoxygenase
IPB001885 Mammalian lipoxygenase signature


UniProtKB/Swiss-Prot: LX15B_HUMAN, O15296
Similarity: Belongs to the lipoxygenase family
Similarity: Contains 1 lipoxygenase domain
Similarity: Contains 1 PLAT domain


ALOX15B for domains           About GeneDecksing


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Molecular Function:

     UniProtKB/Swiss-Prot Summary: LX15B_HUMAN, O15296
Function: Non-heme iron-containing dioxygenase that catalyzes the stereo-specific peroxidation of free and
esterified polyunsaturated fatty acids generating a spectrum of bioactive lipid mediators. Converts arachidonic
acid to 15S-hydroperoxyeicosatetraenoic acid/(15S)-HPETE. Also acts on linoleic acid to produce
13-hydroxyoctadecadienoic acid/13-HPODE. Has no detectable 8S-lipoxygenase activity but reacts with (8S)-HPETE to
produce (8S,15S)-diHPETE. May regulate progression through the cell cycle and cell proliferation. May also
regulate cytokine secretion by macrophages and therefore play a role in the immune response. May also regulate
macrophages differentiation into proatherogenic foam cells
Catalytic activity: Arachidonate + O(2) = (5Z,8Z,11Z,13E)-(15S)-15-hydroperoxyicosa-5,8,11,13-tetraenoate
Catalytic activity: Linoleate + O(2) = (9Z,11E)-13-hydroxyoctadeca-9,11-dienoate
Biophysicochemical properties: Kinetic parameters: KM=1100 uM for arachidonate (isoform D at pH 7.4 and 20 degrees
Celsius); KM=10 uM for linoleate (isoform A at pH 7.4 and 20 degrees Celsius); KM=25 uM for arachidonate (isoform
A at pH 7.4 and 20 degrees Celsius); Vmax=4 umol/min/mg enzyme with arachidonate as substrate (isoform A at pH
7.4 and 20 degrees Celsius); Vmax=2 umol/min/mg enzyme with arachidonate as substrate (isoform D at pH 7.4 and 20
degrees Celsius); Vmax=4 umol/min/mg enzyme with linoleate as substrate (isoform A at pH 7.4 and 20 degrees
Celsius);
Induction: Up-regulated by UV-irradiation

     Enzyme Numbers (IUBMB): EC 1.13.11.331 2 EC 1.13.11.-1 EC 1.13.112

     Gene Ontology (GO): Selected molecular function terms (see all 7):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005506iron ion binding IEA--
GO:0005515protein binding ----
GO:0016165linoleate 13S-lipoxygenase activity IDA10542053
GO:0016702oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen ----
GO:0036403arachidonate 8(S)-lipoxygenase activity IEA--
     
ALOX15B for ontologies           About GeneDecksing


Animal Models:
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SwitchGear 3'UTR luciferase reporter plasmidALOX15B 3' UTR sequence
Inhib. RNA
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Predesigned siRNA for gene silencing in human, mouse, rat ALOX15B

Gene Editing
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OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
GenScript: all cDNA clones in your preferred vector (see all 3): ALOX15B (NM_001141)
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Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ALOX15B

Cell Line
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In Situ Assay
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Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ALOX15B


(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from UniProtKB/Swiss-Prot
LX15B_HUMAN, O15296: Isoform A: Nucleus. Note=Other isoforms are excluded from the nucleus
LX15B_HUMAN, O15296: Cytoplasm, cytosol. Cell membrane. Cytoplasm, cytoskeleton. Note=Predominantly cytosolic but
associated with other subcellular location like membranes where it is enriched upon stimulation by calcium
Subcellular locations from COMPARTMENTS: 

CompartmentConfidence
cytosol4
nucleus2
extracellular1

Gene Ontology (GO): Selected cellular component terms (see all 7):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005622intracellular IDA11839751
GO:0005634nucleus IEA--
GO:0005737cytoplasm IDA--
GO:0005829cytosol TAS--
GO:0005856cytoskeleton IDA12704195

ALOX15B for ontologies           About GeneDecksing


(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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SuperPaths for ALOX15B About    
See pathways by source

SuperPathContained pathways About
1Arachidonic acid metabolism
Arachidonic acid metabolism0.41
HETE and HPETE biosynthesis and metabolism0.33
Arachidonic acid metabolism0.40
Synthesis of 15-eicosatetraenoic acid derivatives0.00
2Metabolism
Metabolism0.38
Metabolism of lipids and lipoproteins0.37
Metabolic pathways0.38
3Circadian entrainment
Serotonergic synapse0.33
4Selenium Pathway
Selenium Pathway
5Eicosanoid Synthesis
Eicosanoid Synthesis

Pathways by source                                                                                                                                                                 See SuperPaths
Show all pathways


1 GeneGo (Thomson Reuters) Pathway for ALOX15B
    HETE and HPETE biosynthesis and metabolism

2 BioSystems Pathways for ALOX15B
    Eicosanoid Synthesis
Selenium Pathway


1 Reactome Pathway for ALOX15B
    Synthesis of 15-eicosatetraenoic acid derivatives


3 Kegg Pathways  (Kegg details for ALOX15B):
    Arachidonic acid metabolism
Metabolic pathways
Serotonergic synapse

UniProtKB/Swiss-Prot: LX15B_HUMAN, O15296
Pathway: Lipid metabolism; hydroperoxy eicosatetraenoic acid biosynthesis


ALOX15B for pathways           About GeneDecksing

    Pathway & Disease-focused RT2 Profiler PCR Array including ALOX15B: 

          Apoptosis 384HT in human mouse rat

Interactions:

    GeneGlobe Interaction Network for ALOX15B

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

Selected Interacting proteins for ALOX15B (ENSP000003695304) via UniProtKB, MINT, STRING, and/or I2D (see all 43)
InteractantInteraction Details
GeneCardExternal ID(s)
ALOX12ENSP000002515354STRING: ENSP00000251535
ALOX12BENSP000003151674STRING: ENSP00000315167
ALOX15ENSP000002937614STRING: ENSP00000293761
ALOX5ENSP000003635124STRING: ENSP00000363512
CYP2B6ENSP000003246484STRING: ENSP00000324648
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Gene Ontology (GO): Selected biological process terms (see all 18):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0006629lipid metabolic process TAS11839751
GO:0006915apoptotic process TAS11839751
GO:0008285negative regulation of cell proliferation IMP12704195
GO:0010744positive regulation of macrophage derived foam cell differentiation IMP--
GO:0019369arachidonic acid metabolic process TAS--

ALOX15B for ontologies           About GeneDecksing



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore
   Browse drugs & compounds from Enzo Life Sciences
  Browse compounds at ApexBio 

Browse Tocris compounds for ALOX15B (LX15B)

7 HMDB Compounds for ALOX15B    About this table
CompoundSynonyms CAS #PubMed Ids
13-L-Hydroperoxylinoleic acid(13S,9z,11e)-13-hydroperoxy-9,11-octadecadienoic acid (see all 18)33964-75-9--
15(S)-HPETE(5Z,8Z,11Z,13E)-(15S)-15-Hydroperoxyicosa-5,8,11,13-tetraenoate (see all 8)70981-96-3--
8(S)-HPETE8S-hydoperoxy-5Z,9E,11Z,14Z-eicosatetraenoic acid (see all 3)----
Arachidonic acid5,8,11,14-Eicosatetraenoic acid (see all 16)506-32-1--
IronArmco iron (see all 19)7439-89-6--
Linoleic acid(9Z,12Z)-9,12-Octadecadienoate (see all 26)60-33-3--
OxygenOxygen (see all 5)7782-44-7--

7 Novoseek inferred chemical compound relationships for ALOX15B gene    About this table
Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
15-hydroxyeicosatetraenoic acid 88.3 7 11571629 (3), 11442747 (1), 15533897 (1), 18202670 (1)
arachidonic acid 74.1 20 9177185 (2), 12727848 (1), 12704195 (1), 11212240 (1) (see all 13)
ns 398 59.8 3 12659684 (1), 16874012 (1)
linoleic acid 54.5 2 9177185 (1), 16566819 (1)
phorbol 48.7 1 10625675 (1)
paraffin 12 2 11014584 (1)
steroid 0 1 16682954 (1)



ALOX15B for compounds           About GeneDecksing



(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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REFSEQ mRNAs for ALOX15B gene (3 alternative transcripts): 
NM_001039130.1  NM_001039131.1  NM_001141.2  

Unigene Cluster for ALOX15B:

Arachidonate 15-lipoxygenase, type B
Hs.111256  [show with all ESTs]
Unigene Representative Sequence: BC033294
5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000380183(uc002gju.3 uc002gjv.3 uc002gjw.3 uc010vun.2)
ENST00000572022 ENST00000571240(uc010cnp.3) ENST00000573359 ENST00000380173

miRNA
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hsa-miR-2052 hsa-miR-330-5p hsa-miR-326 hsa-miR-26b* hsa-miR-323b-5p
SwitchGear 3'UTR luciferase reporter plasmidALOX15B 3' UTR sequence
Inhib. RNA
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Predesigned siRNA for gene silencing in human, mouse, rat ALOX15B
Clone
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OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
GenScript: all cDNA clones in your preferred vector (see all 3): ALOX15B (NM_001141)
DNA2.0 Custom Codon Optimized Gene Synthesis Service for ALOX15B
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ALOX15B
Primer
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Pre-validated RT2 qPCR Primer Assay in human, mouse, rat ALOX15B
  QuantiTect SYBR Green Assays in human, mouse, rat ALOX15B
  QuantiFast Probe-based Assays in human, mouse, rat ALOX15B

Additional mRNA sequence: 

AF468051.1 AF468052.1 AF468053.1 AF468054.1 AK292779.1 AK298095.1 AK300554.1 BC033294.1 
BC035217.1 BC063647.1 U78294.1 

7 DOTS entries:

DT.108481  DT.101981385  DT.97790313  DT.97836298  DT.102822610  DT.92419921  DT.99958412 

Selected AceView cDNA sequences (see all 63):

CA307212 AI817643 CB051073 AI695749 AI474406 BG739709 BG740579 AI829771 
BG696804 AA468451 CA405703 NM_001141 BG698185 BG675344 BG697910 U78294 
AW294456 BG674800 BG742611 BX106451 BX343731 AA595521 BG743633 BG675395 

GeneLoc Exon Structure

5 Alternative Splicing Database (ASD) splice patterns (SP) for ALOX15B    About this scheme

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12a · 12b ^ 13 ^ 14a · 14b
SP1:                          -                                                                 -                           
SP2:                          -                                         -                       -                           
SP3:                          -                                         -           -     -     -                           
SP4:                                                                                                                        
SP5:                                                                                                                        


ECgene alternative splicing isoforms for ALOX15B

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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ALOX15B expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: CCCATAATCC
ALOX15B Expression
About this image


ALOX15B expression in embryonic tissues and stem cells    About this table
Data from LifeMap, the Embryonic Development and Stem Cells Database
 selected tissues (see all 2) fully expand
 
 Bone (Muscoskeletal System)
         HyStem+BMP4-induced MEL2 cells
 
 Prostate (Endocrine System)
ALOX15B Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

ALOX15B Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.111256

UniProtKB/Swiss-Prot: LX15B_HUMAN, O15296
Tissue specificity: Expressed in hair, prostate, lung, ovary, lymph node, spinal cord and cornea

    Pathway & Disease-focused RT2 Profiler PCR Array including ALOX15B: 
          Apoptosis 384HT in human mouse rat

Primer
Products:
OriGene qSTAR qPCR primer pairs in human, mouse for ALOX15B
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(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of chordates.

Orthologs for ALOX15B gene from Selected species (see all 11)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Alox81 , 5 arachidonate 8-lipoxygenase1, 5 80.33(n)1
78.11(a)1
  11 (42.38 cM)5
116881  NM_009661.41  NP_033791.11 
 691839325 
chicken
(Gallus gallus)
Aves ALOXE31 arachidonate lipoxygenase 3 59.95(n)
51.13(a)
  425997  XM_423676.4  XP_423676.4 
lizard
(Anolis carolinensis)
Reptilia --
--
(see all 6)
Uncharacterized protein
(see all 6)
53(a)
51(a)
(see all 6)
many ↔ many
many ↔ many
(see all 6)
GL343400.1(684955-695029)
GL343400.1(726949-745560)
African clawed frog
(Xenopus laevis)
Amphibia Xl.252382 Xenopus laevis transcribed sequence with weak similarity more 73.98(n)    BJ627300.1 
zebrafish
(Danio rerio)
Actinopterygii ALOXE36
arachidonate lipoxygenase 3
40(a)
1 → many
21(29958222-29989099) ENSDARG00000016789


ENSEMBL Gene Tree for ALOX15B (if available)
TreeFam Gene Tree for ALOX15B (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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Paralogs for ALOX15B gene
ALOX12B2  ALOX52  ALOXE32  ALOX152  ALOX122  
6 SIMAP similar genes for ALOX15B using alignment to 2 protein entries:     LX15B_HUMAN (see all proteins):
arachidonate 12-lipoxygenase    ALOX12B    ALOXE3    ALOX5    ALOX15    ALOX12

ALOX15B for paralogs           About GeneDecksing


1 Pseudogenes.org Pseudogene for ALOX15B
PGOHUM00000262362


(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for ALOX15B (see all 442)    About this table    
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 17 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs1920799231,2
--7929339(+) TCACTA/GCAACC 3 -- us2k10--------
rs1842988201,2
--7929362(+) GTTCAA/GGTGAT 3 -- us2k10--------
rs1418647271,2
--7929389(+) CCTGAA/GTAGCT 3 -- us2k10--------
rs1117829661,2
F--7929456(+) GTAGCC/TGGAAT 3 -- us2k11Minor allele frequency- T:0.50CSA 2
rs1881326141,2
--7929561(+) TCGTGA/TTCTGC 3 -- us2k10--------
rs1484620441,2
--7929586(+) CAAAGC/TTCTGA 3 -- us2k10--------
rs1924074491,2
C--7929623(+) GACCAA/TGATCT 3 -- us2k10--------
rs46005161,2
C,F,A--7929636(+) TTCTTC/TTTCAT 3 -- us2k17Minor allele frequency- T:0.48WA NA CSA EA 365
rs44686901,2
C,F,A,H--7929728(+) ACAGGC/TACAAG 3 -- us2k130Minor allele frequency- T:0.19NS EA NA MN CSA WA 3173
rs728415011,2
C,F--7929751(+) CTGCCG/AGCATC 3 -- us2k12Minor allele frequency- A:0.05NA EA 240

HapMap Linkage Disequilibrium report for ALOX15B (7942335 - 7952452 bp)

Structural Variations
     Database of Genomic Variants (DGV) 2 variations for ALOX15B:    About this table    
Variant IDTypeSubtypePubMed ID
nsv833352CNV Loss17160897
nsv528325CNV Loss19592680

Site Specific Mutation Identification with PCR Assays
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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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OMIM gene information: 603697    OMIM disorders: --

Selected diseases for ALOX15B (see all 23):    
About MalaCards
prostate adenocarcinoma    autosomal recessive congenital ichthyosis    congenital ichthyosiform erythroderma    narcolepsy
esophageal cancer    childhood leukemia    prostate cancer    prostatitis
hypoxia    meningioma    psoriasis    inflammatory bowel disease
adenocarcinoma    esophagitis    asthma    retinitis
ovarian cancer    colorectal cancer    lung cancer    squamous cell carcinoma


ALOX15B for disorders           About GeneDecksing

Selected Novoseek inferred disease relationships for ALOX15B gene (see all 13)    About this table

Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
prostate carcinoma 55 9 11014584 (2), 11212240 (1), 15257547 (1), 12189136 (1) (see all 5)
prostatic adenocarcinoma 52.7 9 10393855 (4), 11014584 (1), 11442747 (1)
prostatic intraepithelial neoplasia 44.9 1 11014584 (1)
prostate cancer 41.9 18 11839751 (5), 20428779 (2), 12189136 (2), 12085962 (1) (see all 7)
hnscc 38.1 2 16874012 (1)
tumors 27.5 55 11014584 (7), 12704195 (3), 15257547 (3), 15799828 (3) (see all 13)
premalignant 23.8 1 12659684 (1)
carcinoma squamous cell 14.3 3 16581564 (1), 16874012 (1)
carcinoma 14 10 16874012 (5), 16581564 (1), 15257547 (1), 11442747 (1)
inflammation 4.7 1 19912316 (1)

Genetic Association Database (GAD): ALOX15B
Human Genome Epidemiology (HuGE) Navigator: ALOX15B (7 documents)

Export disorders for ALOX15B gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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PubMed articles for ALOX15B gene, integrated from 10 sources (see all 84):
(articles sorted by number of sources associating them with ALOX15B)
    Utopia: connect your pdf to the dynamic
world of online information

  1. Discovery of a second 15S-lipoxygenase in humans. (PubMed id 9177185)1, 2, 3, 9 Brash A.R.... Chang M.S. (Proc. Natl. Acad. Sci. U.S.A. 1997)
  2. Subcellular localization and tumor-suppressive functions of 15-lipoxygenase 2 (15-LOX2) and its splice variants. (PubMed id 12704195)1, 2, 9 Bhatia B....Tang D.G. (J. Biol. Chem. 2003)
  3. Evidence that arachidonate 15-lipoxygenase 2 is a negative cell cycle regulator in normal prostate epithelial cells. (PubMed id 11839751)1, 2, 9 Tang S.... Tang D.G. (J. Biol. Chem. 2002)
  4. 15-Lipoxygenase-2 expression in human macrophages induces chemokine secretion and T cell migration. (PubMed id 18067895)1, 2, 9 Danielsson K.N....HultAcn L.M. (Atherosclerosis 2008)
  5. A gene cluster encoding human epidermis-type lipoxygenases at chromosome 17p13.1: cloning, physical mapping, and expression. (PubMed id 11350124)1, 2, 9 Krieg P.... Fuerstenberger G. (Genomics 2001)
  6. Differential characteristics of human 15-lipoxygenase isozymes and a novel splice variant of 15S-lipoxygenase. (PubMed id 10542053)1, 2, 9 Kilty I.... Vickers P.J. (Eur. J. Biochem. 1999)
  7. Risk of meningioma and common variation in genes related to innate immunity. (PubMed id 20406964)1, 4 Rajaraman P....Inskip P.D. (amp 2010)
  8. Polymorphisms in innate immunity genes and risk of childhood leukemia. (PubMed id 20438785)1, 4 Han S....Kang D. (Hum. Immunol. 2010)
  9. An approach based on a genome-wide association study reveals candidate loci for narcolepsy. (PubMed id 20677014)1, 4 Shimada M....Tokunaga K. (Hum. Genet. 2010)
  10. Polymorphism in the IL18 gene and epithelial ovarian cancer in non-Hispanic white women. (PubMed id 19064572)1, 4 Palmieri R.T.... . (amp 2008)

(in PubMed, OMIM, and NCBI Bookshelf)
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 ANDOR
Aliases
Disorders
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 247 HGNC: 434 AceView: ALOX15B Ensembl:ENSG00000179593 euGenes: HUgn247
ECgene: ALOX15B Kegg: 247 H-InvDB: ALOX15B

(According to HUGE)
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  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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NameDescription
PharmGKB entry for ALOX15B Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for ALOX15B gene:
Search GeneIP for patents involving ALOX15B

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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