Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



ALOX15 Gene

protein-coding   GIFtS: 65
GCID: GC17M004534

Arachidonate 15-Lipoxygenase

  See ALOX15-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Arachidonate 15-Lipoxygenase1 2     15-lipooxygenase-12
Arachidonate 12-Lipoxygenase, Leukocyte-Type2 3     15LOX-12
Arachidonate Omega-6 Lipoxygenase2 3     EC 1.13.11.313
12-LOX2 3     EC 1.13.11.333
12/15-lipoxygenase2 3     LOG153
15-LOX2 3     EC 1.13.118
15-LOX-12 3     

External Ids:    HGNC: 4331   Entrez Gene: 2462   Ensembl: ENSG000001619057   OMIM: 1523925   UniProtKB: P160503   

Export aliases for ALOX15 gene to outside databases

Previous GC identifers: GC17M004960 GC17M004879 GC17M004485 GC17M004740 GC17M004480


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

GeneCards Summary for ALOX15 Gene:
ALOX15 (arachidonate 15-lipoxygenase) is a protein-coding gene. Diseases associated with ALOX15 include spinal meningioma, and prostate adenocarcinoma. GO annotations related to this gene include arachidonate 15-lipoxygenase activity and iron ion binding. An important paralog of this gene is ALOX12B.

UniProtKB/Swiss-Prot: LOX15_HUMAN, P16050
Function: Non-heme iron-containing dioxygenase that catalyzes the stereo-specific peroxidation of free and
esterified polyunsaturated fatty acids generating a spectrum of bioactive lipid mediators. Converts arachidonic
acid into 12-hydroperoxyeicosatetraenoic acid/12-HPETE and 15-hydroperoxyeicosatetraenoic acid/15-HPETE. Also
converts linoleic acid to 13-hydroperoxyoctadecadienoic acid. May also act on (12S)-hydroperoxyeicosatetraenoic
acid/(12S)-HPETE to produce hepoxilin A3. Probably plays an important role in the immune and inflammatory
responses. Through the oxygenation of membrane-bound phosphatidylethanolamine in macrophages may favor clearance
of apoptotic cells during inflammation by resident macrophages and prevent an autoimmune response associated with
the clearance of apoptotic cells by inflammatory monocytes. In parallel, may regulate actin polymerization which
is crucial for several biological processes, including macrophage function. May also regulate macrophage function
through regulation of the peroxisome proliferator activated receptor signaling pathway. Finally, it is also
involved in the cellular response to IL13/interleukin-13. Beside its role in the immune and inflammatory
responses, may play a role in epithelial wound healing in the cornea maybe through production of lipoxin A4. May
also play a role in endoplasmic reticulum stress response and the regulation of bone mass

summary for ALOX15 Gene:
Lipoxygenases (LOXs) are a family of non-heme iron dioxygenases that are involved in the production and
metabolism of fatty acid hydroperoxidases. There are six lipoxygenase isozymes; 5-LOX, 12R-LOX, 12S-LOX,
15-LOX-1 and 15-LOX-2, which catalyze the regio-selective addition of oxygen into arachidonic acid, and
epidermal LOX (E-LOX) which metabolizes 12R-hydroperoxyeicosatetraenoic acid (12R-HPETE) to a specific
epoxyalcohol compound. Different isozymes have different physiological roles; 5-, 12R-, 12S- and 15-LOX-1
have proliferative, antiapoptotic and angiogenic functions whilst 15-LOX-2 has roles in differentiation,
growth arrest and the induction of apoptosis. E-LOX, the most divergent member of this family, is involved
in terminal differentiation of keratinocytes and has a major role in skin barrier function. Perturbations in
lipoxygenase enzymes have been implicated in various human diseases including bronchial asthma,
atherosclerosis, osteoporosis and some cancers.

Gene Wiki entry for ALOX15 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence at NCBI GenBank:
NC_000017.10  NC_018928.2  NT_010718.17  
Regulatory elements:
   Regulatory transcription factor binding sites in the ALOX15 gene promoter:
         Sp1   LUN-1   LCR-F1   GATA-1   Max   HOXA5   ZID   ATF   c-Myc   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidALOX15 promoter sequence
   Search Chromatin IP Primers for ALOX15

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ALOX15


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17p13.3   Ensembl cytogenetic band:  17p13.2   HGNC cytogenetic band: 17p13.3

ALOX15 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ALOX15 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17M004534:  view genomic region     (about GC identifiers)

Start:
4,534,197 bp from pter      End:
4,545,589 bp from pter
Size:
11,393 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: LOX15_HUMAN, P16050 (See protein sequence)
Recommended Name: Arachidonate 15-lipoxygenase  
Size: 662 amino acids; 74804 Da
Cofactor: Binds 1 iron ion per subunit (By similarity)
Subunit: Interacts with PEBP1; in response to IL13/interleukin-13, prevents the interaction of PEBP1 with RAF1 to
activate the ERK signaling cascade
1 PDB 3D structure from and Proteopedia for ALOX15:
2ABT (3D)    
Secondary accessions: A8K2P4 Q8N6R7 Q99657

Explore the universe of human proteins at neXtProt for ALOX15: NX_P16050

Explore proteomics data for ALOX15 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for ALOX15 (P16050) (see all 20)
     RYTLEIN  CPPDDLA  EEYFSGP  HLGQLDW 


    See ALOX15 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_001131.3  
    ENSEMBL proteins: 
     ENSP00000458832   ENSP00000460483   ENSP00000460430   ENSP00000458630   ENSP00000439855  
     ENSP00000293761  
    Reactome Protein details: P16050

    ALOX15 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for ALOX15
    OriGene Protein Over-expression Lysate for ALOX15
    OriGene MassSpec for ALOX15
    OriGene Custom Protein Services for ALOX15
    GenScript Custom Purified and Recombinant Proteins Services for ALOX15
    Novus Biologicals ALOX15 Protein
    Novus Biologicals ALOX15 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for ALOX15

     
    Search eBioscience for Proteins for ALOX15 

    ALOX15 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    OriGene Antibodies for ALOX15
    OriGene Custom Antibody Services for ALOX15
    Novus Biologicals ALOX15 Antibodies
    Abcam antibodies for ALOX15
    Cloud-Clone Corp. Antibodies for ALOX15
    ThermoFisher Antibodies for ALOX15
    LSBio Antibodies in human, mouse, rat for ALOX15

    ALOX15 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for ALOX15
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for ALOX15
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for ALOX15
    Cloud-Clone Corp. CLIAs for ALOX15
    Search eBioscience for ELISAs for ALOX15 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    HGNC Gene Families:
    ALOX: Arachidonate lipoxygenases

    IUPHAR Guide to PHARMACOLOGY protein family classification: 15-LOX-1
    Lipoxygenases

    Selected InterPro protein domains (see all 7):
     IPR020833 LipOase_Fe_BS
     IPR013819 LipOase_C
     IPR001024 PLAT/LH2_dom
     IPR008976 Lipase_LipOase
     IPR020834 LipOase_CS

    Graphical View of Domain Structure for InterPro Entry P16050

    ProtoNet protein and cluster: P16050

    3 Blocks protein domains:
    IPB000907 Lipoxygenase
    IPB001024 Lipoxygenase
    IPB001885 Mammalian lipoxygenase signature


    UniProtKB/Swiss-Prot: LOX15_HUMAN, P16050
    Similarity: Belongs to the lipoxygenase family
    Similarity: Contains 1 lipoxygenase domain
    Similarity: Contains 1 PLAT domain


    Find genes that share domains with ALOX15           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: LOX15_HUMAN, P16050
    Function: Non-heme iron-containing dioxygenase that catalyzes the stereo-specific peroxidation of free and
    esterified polyunsaturated fatty acids generating a spectrum of bioactive lipid mediators. Converts arachidonic
    acid into 12-hydroperoxyeicosatetraenoic acid/12-HPETE and 15-hydroperoxyeicosatetraenoic acid/15-HPETE. Also
    converts linoleic acid to 13-hydroperoxyoctadecadienoic acid. May also act on (12S)-hydroperoxyeicosatetraenoic
    acid/(12S)-HPETE to produce hepoxilin A3. Probably plays an important role in the immune and inflammatory
    responses. Through the oxygenation of membrane-bound phosphatidylethanolamine in macrophages may favor clearance
    of apoptotic cells during inflammation by resident macrophages and prevent an autoimmune response associated with
    the clearance of apoptotic cells by inflammatory monocytes. In parallel, may regulate actin polymerization which
    is crucial for several biological processes, including macrophage function. May also regulate macrophage function
    through regulation of the peroxisome proliferator activated receptor signaling pathway. Finally, it is also
    involved in the cellular response to IL13/interleukin-13. Beside its role in the immune and inflammatory
    responses, may play a role in epithelial wound healing in the cornea maybe through production of lipoxin A4. May
    also play a role in endoplasmic reticulum stress response and the regulation of bone mass
    Catalytic activity: Arachidonate + O(2) = (5Z,8Z,10E,14Z)-(12S)-12-hydroperoxyicosa-5,8,10,14-tetraenoate
    Catalytic activity: Arachidonate + O(2) = (5Z,8Z,11Z,13E)-(15S)-15-hydroperoxyicosa-5,8,11,13-tetraenoate
    Induction: Up-regulated by UV-irradiation

         Genatlas biochemistry entry for ALOX15:
    arachidonate-15-lipoxygenase,lipid peroxidating enzyme implicated in the pathogenesis of inflammatory disorders as
    well as membrane remodeling,carcinogenesis,and atheroma formation,upregulated by mutant TP53 and maybe involved
    in the development of prostate or colorectal carcinomas

         Enzyme Numbers (IUBMB): EC 1.13.11.311 EC 1.13.11.331 EC 1.13.112

         Gene Ontology (GO): Selected molecular function terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004052arachidonate 12-lipoxygenase activity IDA1944593
    GO:0005506iron ion binding ISS--
    GO:0005515protein binding IPI--
    GO:0016702oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen ----
    GO:0046872metal ion binding ----
         
    Find genes that share ontologies with ALOX15           About GenesLikeMe


    Phenotypes:
         4 GenomeRNAi human phenotypes for ALOX15:
     Decreased focal adhesion (FA)   Decreased homologous recombina  Increased G1 DNA content  Increased number of mitotic ce 

         8 MGI mutant phenotypes (inferred from 1 allele(MGI details for Alox15):
     cardiovascular system  endocrine/exocrine gland  hematopoietic system  immune system  integument 
     mortality/aging  reproductive system  tumorigenesis 

    Find genes that share phenotypes with ALOX15           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Alox15tm1Fun for ALOX15

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for ALOX15
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for ALOX15

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for ALOX15
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for ALOX15

    miRNA
    Products:
        
    Block miRNA regulation of human, mouse, rat ALOX15 using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate ALOX15
    SwitchGear 3'UTR luciferase reporter plasmidALOX15 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for ALOX15
    Predesigned siRNA for gene silencing in human, mouse, rat ALOX15

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for ALOX15

    Clone
    Products:
         
    OriGene clones in human, mouse for ALOX15 (see all 7)
    OriGene ORF clones in mouse, rat for ALOX15
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: ALOX15 (NM_001140)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ALOX15
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ALOX15

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for ALOX15
    Browse ESI BIO Cell Lines and PureStem Progenitors for ALOX15 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ALOX15


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    LOX15_HUMAN, P16050: Cytoplasm, cytosol. Cell membrane. Lipid droplet. Note=Translocates from the cytosol to the
    plasma membrane when stimulated by IL13/interleukin-13 and in macrophages binding apoptotic cells
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol4
    nucleus4
    mitochondrion1
    peroxisome1

    Gene Ontology (GO): Selected cellular component terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus ----
    GO:0005737cytoplasm ----
    GO:0005811lipid particle IDA19528634
    GO:0005829cytosol TAS--
    GO:0005886plasma membrane ISS--

    Find genes that share ontologies with ALOX15           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus

    SuperPaths for ALOX15 About   (see all 6)  
    See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1Arachidonic acid metabolism
    Linoleic acid metabolism0.64
    Synthesis of 15-eicosatetraenoic acid derivatives0.00
    Arachidonic acid metabolism0.41
    resolvin D biosynthesis0.00
    Arachidonic acid metabolism0.40
    Synthesis of 12-eicosatetraenoic acid derivatives0.00
    HETE and HPETE biosynthesis and metabolism0.33
    lipoxin biosynthesis0.00
    2Metabolism
    Metabolism0.38
    Metabolism of lipids and lipoproteins0.37
    Metabolic pathways0.38
    3Apoptotic Pathways in Synovial Fibroblasts
    DHA Signaling0.74
    4Circadian entrainment
    Serotonergic synapse0.33
    5IL4-mediated signaling events
    IL4-mediated signaling events


    Find genes that share SuperPaths with ALOX15           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 Downloadable PowerPoint Slide of GeneGlobe Pathway Central Maps for ALOX15
        DHA Signaling

    1 GeneGo (Thomson Reuters) Pathway for ALOX15
        HETE and HPETE biosynthesis and metabolism

    4 BioSystems Pathways for ALOX15
        Eicosanoid Synthesis
    lipoxin biosynthesis
    IL4-mediated signaling events
    resolvin D biosynthesis

    3 Reactome Pathways for ALOX15
        Synthesis of Leukotrienes (LT) and Eoxins (EX)
    Synthesis of 15-eicosatetraenoic acid derivatives
    Synthesis of 12-eicosatetraenoic acid derivatives


    4 Kegg Pathways  (Kegg details for ALOX15):
        Arachidonic acid metabolism
    Linoleic acid metabolism
    Metabolic pathways
    Serotonergic synapse

    UniProtKB/Swiss-Prot: LOX15_HUMAN, P16050
    Pathway: Lipid metabolism; hydroperoxy eicosatetraenoic acid biosynthesis

        Pathway & Disease-focused RT2 Profiler PCR Array including ALOX15: 

              Drug Metabolism in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for ALOX15

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for ALOX15 (ENSP000002937614) via UniProtKB, MINT, STRING, and/or I2D (see all 48)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ALOX12ENSP000002515354STRING: ENSP00000251535
    ALOX12BENSP000003151674STRING: ENSP00000315167
    ALOX15BENSP000003695304STRING: ENSP00000369530
    ALOX5ENSP000003635124STRING: ENSP00000363512
    CYP2B6ENSP000003246484STRING: ENSP00000324648
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 21):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001503ossification ISS--
    GO:0002820negative regulation of adaptive immune response ISS--
    GO:0006646phosphatidylethanolamine biosynthetic process ISS--
    GO:0006691leukotriene metabolic process TAS--
    GO:0006954inflammatory response TAS10200270

    Find genes that share ontologies with ALOX15           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Compounds for ALOX15 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    BAY-X 1005Orally active 5-lipoxygenase activating protein (FLAP) inhibitor[128253-31-6]
    BW-B 70C5-Lipoxygenase inhibitor[134470-38-5]
    ZileutonOrally active 5-LOX inhibitor[111406-87-2]
    MK 886Inhibitor of 5-lipoxygenase-activating protein (FLAP)[118414-82-7]
    Baicalein5- and 12-Lipoxygenase inhibitor[491-67-8]

    7 HMDB Compounds for ALOX15    About this table
    CompoundSynonyms CAS #PubMed Ids
    13-L-Hydroperoxylinoleic acid(13S,9z,11e)-13-hydroperoxy-9,11-octadecadienoic acid (see all 18)33964-75-9--
    15(S)-HPETE(5Z,8Z,11Z,13E)-(15S)-15-Hydroperoxyicosa-5,8,11,13-tetraenoate (see all 8)70981-96-3--
    9(S)-HPODE ----
    Arachidonic acid5,8,11,14-Eicosatetraenoic acid (see all 16)506-32-1--
    IronArmco iron (see all 19)7439-89-6--
    Linoleic acid(9Z,12Z)-9,12-Octadecadienoate (see all 26)60-33-3--
    OxygenOxygen (see all 5)7782-44-7--

    1 DrugBank Compound for ALOX15    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    (2E)-3-(2-OCT-1-YN-1-YLPHENYL)ACRYLIC ACID-- --target--10592235

    Selected Novoseek inferred chemical compound relationships for ALOX15 gene (see all 19)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    (13s)-hydroxyoctadecadienoic acid 90.9 5 10506115 (1), 20388757 (1), 12510822 (1)
    15hpete 82.5 2 17305569 (1), 10332966 (1)
    15-hydroxyeicosatetraenoic acid 81.6 7 10332966 (3), 17519227 (1), 20008149 (1)
    arachidonic acid 79.9 50 1662607 (2), 8195716 (2), 16598376 (2), 10332966 (2) (see all 29)
    13-hpode 73.9 7 10400618 (4)
    linoleic acid 59.6 5 10506115 (1), 9931410 (1), 12510822 (1), 17869078 (1)
    n-(4-hydroxyphenyl)retinamide 49.2 3 12858336 (1), 12234979 (1)
    gamma-linolenic acid 44.9 3 15850718 (1), 12510822 (1)
    pge2 27 2 12510822 (1)
    lipid 22.1 5 10400618 (2), 1729692 (1), 17918787 (1), 19804839 (1)



    Find genes that share compounds with ALOX15           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for ALOX15 gene: 
    NM_001140.3  

    Unigene Cluster for ALOX15:

    Arachidonate 15-lipoxygenase
    Hs.73809  [show with all ESTs]
    Unigene Representative Sequence: NM_001140
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000570836(uc002fyh.3 uc010vsd.2 uc010vse.2) ENST00000574640
    ENST00000576572 ENST00000572265 ENST00000573740 ENST00000576394 ENST00000545513
    ENST00000293761
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat ALOX15 using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate ALOX15
    SwitchGear 3'UTR luciferase reporter plasmidALOX15 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for ALOX15
    Predesigned siRNA for gene silencing in human, mouse, rat ALOX15
    Clone
    Products:
         
    OriGene clones in human, mouse for ALOX15 (see all 7)
    OriGene ORF clones in mouse, rat for ALOX15
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: ALOX15 (NM_001140)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ALOX15
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ALOX15
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for ALOX15
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat ALOX15
      QuantiTect SYBR Green Assays in human, mouse, rat ALOX15
      QuantiFast Probe-based Assays in human, mouse, rat ALOX15

    Additional mRNA sequence: 

    AK290309.1 AK296792.1 AK296821.1 AK296904.1 AK312557.1 AK316126.1 BC029032.1 M23892.1 

    4 DOTS entries:

    DT.100020039  DT.120922324  DT.95153784  DT.121002907 

    23 AceView cDNA sequences:

    NM_001140 BM975468 BQ957032 CB305636 BX282722 M23892 BM975623 BM981991 
    BX113915 BC029032 BM976589 BI823909 BQ276406 AU119118 CA436179 CA311119 
    BX644955 BE538114 BV196138 CA405412 AI864921 BU935146 CN478760 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for ALOX15    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10
    SP1:                                                                              
    SP2:                                                                              
    SP3:                                                                              
    SP4:                                                                              
    SP5:                                                                              


    ECgene alternative splicing isoforms for ALOX15

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    ALOX15 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGTATCTTCA
    ALOX15 Expression
    About this image


    ALOX15 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 3) fully expand
     
     Gut Tube (Gastrointestinal Tract)
             Foregut
     
     Blood (Hematopoietic System)
             Granulocytes Peripheral Blood
     
     Larynx (Respiratory System)
    ALOX15 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ALOX15 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.73809

    UniProtKB/Swiss-Prot: LOX15_HUMAN, P16050
    Tissue specificity: Expressed in airway epithelial cells

        Pathway & Disease-focused RT2 Profiler PCR Array including ALOX15: 
              Drug Metabolism in human mouse rat

    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for ALOX15
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat ALOX15
    QuantiTect SYBR Green Assays in human, mouse, rat ALOX15
    QuantiFast Probe-based Assays in human, mouse, rat ALOX15
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ALOX15

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of chordates.

    Orthologs for ALOX15 gene from Selected species (see all 9)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Alox151 , 5 arachidonate 15-lipoxygenase1, 5 77.79(n)1
    73.72(a)1
      11 (42.99 cM)5
    116871  NM_009660.31  NP_033790.31 
     703441525 
    zebrafish
    (Danio rerio)
    Actinopterygii alox126
    arachidonate 12-lipoxygenase
    44(a)
    1 → many
    7(27155574-27173814) ENSDARG00000069463


    ENSEMBL Gene Tree for ALOX15 (if available)
    TreeFam Gene Tree for ALOX15 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for ALOX15 gene
    ALOX12B2  ALOX52  ALOX15B2  ALOXE32  ALOX122  
    6 SIMAP similar genes for ALOX15 using alignment to 5 protein entries:     LOX15_HUMAN (see all proteins):
    arachidonate 12-lipoxygenase    ALOX12    ALOX5    ALOX15B    ALOX12B    ALOXE3

    Find genes that share paralogs with ALOX15           About GenesLikeMe


    2 Pseudogenes.org Pseudogenes for ALOX15
    PGOHUM00000237211 PGOHUM00000236709


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for ALOX15 (see all 507)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs18093641,2
    C,F,H--4533844(+) ATTTTT/AAAAAA 1 -- int117Minor allele frequency- A:0.08NS NA WA CSA EA 1095
    rs1887427901,2
    --4533859(+) TAGGCC/TGGGCA 1 -- int10--------
    rs1928092341,2
    --4533880(+) CACCTA/GTAATC 1 -- int10--------
    rs115681361,2
    C,F--4533887(-) GTGCTG/AGGATT 1 -- int12Minor allele frequency- A:0.02NS 82
    rs1837874031,2
    C--4534001(+) GGGCGC/TGGTGG 1 -- int10--------
    rs115681501,2
    C,F--4534011(-) CAGGCG/ACCTGC 1 -- int12Minor allele frequency- A:0.01NS 84
    rs115681351,2
    C,F--4534113(-) TGCCCA/TGGCTG 1 -- int12Minor allele frequency- T:0.04NS 84
    rs1918438261,2
    --4534334(+) CCTAGA/GCAACA 1 -- ut310--------
    rs115681341,2
    C,F--4534357(-) TTCGTG/AGAGAC 1 -- ut318Minor allele frequency- A:0.06NS NA WA CSA 268
    rs1840611201,2
    --4534395(+) GGCATA/GAGCCT 1 -- ut310--------

    HapMap Linkage Disequilibrium report for ALOX15 (4534197 - 4545589 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for ALOX15: --
    Human Gene Mutation Database (HGMD): ALOX15
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing ALOX15
    DNA2.0 Custom Variant and Variant Library Synthesis for ALOX15

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 152392    OMIM disorders: --

    UniProtKB/Swiss-Prot: LOX15_HUMAN, P16050
  • Note=Disease susceptibility may be associated with variations affecting the gene represented in this
    entry. Met at position 560 may confer interindividual susceptibility to coronary artery disease (CAD)
    (PubMed:17959182)

  • 5 diseases for ALOX15:    
    About MalaCards
    spinal meningioma    prostate adenocarcinoma    osteoporosis    atherosclerosis
    asthma


    Find genes that share disorders with ALOX15           About GenesLikeMe

    Selected Novoseek inferred disease relationships for ALOX15 gene (see all 11)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    atherosclerosis 45.9 10 17869078 (2), 18000963 (1), 17439326 (1), 18392641 (1) (see all 7)
    inflammation 36.1 7 14740455 (1), 17439326 (1), 19942621 (1), 17164146 (1) (see all 5)
    colorectal cancer 20.8 1 14566836 (1)
    asthma 20.8 4 17439326 (1), 19804839 (1), 16320347 (1), 8358018 (1)
    rheumatoid arthritis 12.9 1 10332966 (1)
    arthritis 12.7 2 17439326 (1), 16320347 (1)
    prostate cancer 9.84 1 15850718 (1)
    osteoporosis 2.61 1 16799083 (1)
    metastasis 0 1 17721268 (1)
    tumors 0 2 14740455 (1)

    Genetic Association Database (GAD): ALOX15
    Human Genome Epidemiology (HuGE) Navigator: ALOX15 (32 documents)

    Export disorders for ALOX15 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for ALOX15 gene, integrated from 10 sources (see all 233):
    (articles sorted by number of sources associating them with ALOX15)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A near null variant of 12/15-LOX encoded by a novel SNP in ALOX15 and the risk of coronary artery disease. (PubMed id 17959182)1, 2, 4, 9 Assimes T.L....Quertermous T. (Atherosclerosis 2008)
    2. Human ALOX12, but not ALOX15, is associated with BMD in white men and women. (PubMed id 16598376)1, 4, 9 Ichikawa S....Econs M.J. (J. Bone Miner. Res. 2006)
    3. Polymorphisms in ALOX12, but not ALOX15, are significantly associated with BMD in postmenopausal women. (PubMed id 17520163)1, 4, 9 Mullin B.H....Wilson S.G. (Calcif. Tissue Int. 2007)
    4. The c.-292C&gt;T promoter polymorphism increases reticulocyte-type 15-lipoxygenase-1 activity and could be atheroprotective. (PubMed id 17439326)1, 4, 9 Wittwer J....Hersberger M. (Clin. Chem. Lab. Med. 2007)
    5. Reciprocal regulation of 12- and 15-lipoxygenases by UV-irradiation in human keratinocytes. (PubMed id 18755188)1, 2, 9 Yoo H....Kim T.Y. (FEBS Lett. 2008)
    6. 15-Lipoxygenase gene variants are associated with carotid plaque but not carotid intima-media thickness. (PubMed id 18392641)1, 4, 9 McCaskie P.A....Palmer L.J. (Hum. Genet. 2008)
    7. Purification of two forms of arachidonate 15-lipoxygenase from human leukocytes. (PubMed id 1662607)1, 2, 9 Izumi T.... Samuelsson B. (Eur. J. Biochem. 1991)
    8. Variation in eicosanoid genes, non-fatal myocardial infarction and ischemic stroke. (PubMed id 19046748)1, 4, 9 Lemaitre R.N....Psaty B.M. (Atherosclerosis 2009)
    9. Association of a single nucleotide polymorphism in the lipoxygenase ALOX15 5'-flanking region (-5229G/A) with bone mineral density. (PubMed id 15838625)1, 4, 9 Urano T....Inoue S. (J. Bone Miner. Metab. 2005)
    10. 15-Lipoxygenase 1 interacts with phosphatidylethanolamine-binding protein to regulate MAPK signaling in human airway epithelial cells. (PubMed id 21831839)1, 2 Zhao J....Wenzel S.E. (Proc. Natl. Acad. Sci. U.S.A. 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 246 HGNC: 433 AceView: ALOX15 Ensembl:ENSG00000161905 euGenes: HUgn246
    ECgene: ALOX15 Kegg: 246 H-InvDB: ALOX15

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for ALOX15 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for ALOX15 Genetics and Cytogenetics in Oncology and Haematology
    SeattleSNPshttp://pga.gs.washington.edu/data/alox15/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for ALOX15 gene:
    Search GeneIP for patents involving ALOX15

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for ALOX15   OriGene RNAi products in human, mouse, rat for ALOX15  
     Browse OriGene qPCR primer pairs and template standards   OriGene Protein Over-expression Lysate for ALOX15  
     OriGene MassSpec something-or-other for ALOX15   OriGene clones in human, mouse for ALOX15  
     OriGene qSTAR qPCR primer pairs in human, mouse for ALOX15   OriGene Purified Protein for ALOX15  
     OriGene ORF clones in mouse, rat for ALOX15   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for ALOX15   OriGene Custom Protein Services for ALOX15  

     
     
     Block miRNA regulation of human, mouse, rat ALOX15 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing ALOX15
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ALOX15 Predesigned siRNA for gene silencing in human, mouse, rat ALOX15
     QuantiFast Probe-based Assays in human, mouse, rat ALOX15 QuantiTect SYBR Green Assays in human, mouse, rat ALOX15
     PCR Arrays including human, mouse, rat ALOX15 Search Chromatin IP Primers for ALOX15
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat ALOX15  GeneGlobe Interaction Network for ALOX15
     Regulatory tfbs in ALOX15 promoter
     GenScript Custom Purified and Recombinant Proteins Services for ALOX15 GenScript cDNA clones with any tag delivered in your preferred vector for ALOX15
     GenScript Custom Assay Services for ALOX15 GenScript Custom overexpressing Cell Line Services for ALOX15
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Tocris compounds for ALOX15
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     ALOX15 antibodies
     ALOX15 proteins
     ALOX15 lysates
     Antibodies for ALOX15
     See all of Abcam's Antibodies, Kits and Proteins for ALOX15
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Proteins for ALOX15
     Antibodies for ALOX15
     ELISAs for ALOX15
     CLIAs for ALOX15



     Browse ESI BIO Cell Lines and PureStem Progenitors for ALOX15
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ALOX15
     SwitchGear 3'UTR luciferase reporter plasmids for ALOX15
     SwitchGear Promoter luciferase reporter plasmids for ALOX15
     ThermoFisher Antibodies for ALOX15
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ALOX15
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for ALOX15
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for ALOX15
     LSBio Antibodies in human, mouse, rat for ALOX15
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
     Search Addgene for plasmids for ALOX15
      Search eBioscience for proteins for ALOX15
      Search eBioscience for elisas for ALOX15
      eBioscience FlowRNA Probe Sets
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      ALOX15 gene at Home site.
    Version: 3.12.224 13 Oct 2014
    hostname: 356977-web1.xennexinc.com index build: 128 solr: 1.4