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Aliases for ALOX15 Gene

Aliases for ALOX15 Gene

  • Arachidonate 15-Lipoxygenase 2 3
  • Arachidonate 12-Lipoxygenase, Leukocyte-Type 3 4
  • Arachidonate Omega-6 Lipoxygenase 3 4
  • 12/15-Lipoxygenase 3 4
  • 15-LOX-1 3 4
  • 12-LOX 3 4
  • 15-LOX 3 4
  • 15-Lipooxygenase-1 3
  • EC 1.13.11.33 4
  • EC 1.13.11.31 4
  • EC 1.13.11 63
  • 15LOX-1 3
  • LOG15 4

External Ids for ALOX15 Gene

Summaries for ALOX15 Gene

GeneCards Summary for ALOX15 Gene

ALOX15 (Arachidonate 15-Lipoxygenase) is a Protein Coding gene. Diseases associated with ALOX15 include prostate adenocarcinoma and atherosclerosis. Among its related pathways are Apoptotic Pathways in Synovial Fibroblasts and Metabolism. GO annotations related to this gene include iron ion binding and arachidonate 15-lipoxygenase activity. An important paralog of this gene is ALOX12.

UniProtKB/Swiss-Prot for ALOX15 Gene

  • Non-heme iron-containing dioxygenase that catalyzes the stereo-specific peroxidation of free and esterified polyunsaturated fatty acids generating a spectrum of bioactive lipid mediators. Converts arachidonic acid into 12-hydroperoxyeicosatetraenoic acid/12-HPETE and 15-hydroperoxyeicosatetraenoic acid/15-HPETE. Also converts linoleic acid to 13-hydroperoxyoctadecadienoic acid. May also act on (12S)-hydroperoxyeicosatetraenoic acid/(12S)-HPETE to produce hepoxilin A3. Probably plays an important role in the immune and inflammatory responses. Through the oxygenation of membrane-bound phosphatidylethanolamine in macrophages may favor clearance of apoptotic cells during inflammation by resident macrophages and prevent an autoimmune response associated with the clearance of apoptotic cells by inflammatory monocytes. In parallel, may regulate actin polymerization which is crucial for several biological processes, including macrophage function. May also regulate macrophage function through regulation of the peroxisome proliferator activated receptor signaling pathway. Finally, it is also involved in the cellular response to IL13/interleukin-13. In addition to its role in the immune and inflammatory responses, may play a role in epithelial wound healing in the cornea maybe through production of lipoxin A4. May also play a role in endoplasmic reticulum stress response and the regulation of bone mass.

Tocris Summary for ALOX15 Gene

  • Lipoxygenases (LOXs) are a family of non-heme iron dioxygenases that are involved in the production and metabolism of fatty acid hydroperoxidases. There are six lipoxygenase isozymes; 5-LOX, 12R-LOX, 12S-LOX, 15-LOX-1 and 15-LOX-2, which catalyze the regio-selective addition of oxygen into arachidonic acid, and epidermal LOX (E-LOX) which metabolizes 12R-hydroperoxyeicosatetraenoic acid (12R-HPETE) to a specific epoxyalcohol compound. Different isozymes have different physiological roles; 5-, 12R-, 12S- and 15-LOX-1 have proliferative, antiapoptotic and angiogenic functions whilst 15-LOX-2 has roles in differentiation, growth arrest and the induction of apoptosis. E-LOX, the most divergent member of this family, is involved in terminal differentiation of keratinocytes and has a major role in skin barrier function. Perturbations in lipoxygenase enzymes have been implicated in various human diseases including bronchial asthma, atherosclerosis, osteoporosis and some cancers.

Gene Wiki entry for ALOX15 Gene

No data available for Entrez Gene Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ALOX15 Gene

Genomics for ALOX15 Gene

Genomic Location for ALOX15 Gene

Start:
4,630,902 bp from pter
End:
4,642,294 bp from pter
Size:
11,393 bases
Orientation:
Minus strand

Genomic View for ALOX15 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ALOX15 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ALOX15 Gene

Regulatory Elements for ALOX15 Gene

Proteins for ALOX15 Gene

  • Protein details for ALOX15 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P16050-LOX15_HUMAN
    Recommended name:
    Arachidonate 15-lipoxygenase
    Protein Accession:
    P16050
    Secondary Accessions:
    • A8K2P4
    • B7ZA11
    • Q8N6R7
    • Q99657

    Protein attributes for ALOX15 Gene

    Size:
    662 amino acids
    Molecular mass:
    74804 Da
    Cofactor:
    Name=Fe cation; Xref=ChEBI:CHEBI:24875; Note=Binds 1 Fe cation per subunit.;
    Quaternary structure:
    • Interacts with PEBP1; in response to IL13/interleukin-13, prevents the interaction of PEBP1 with RAF1 to activate the ERK signaling cascade.

    Three dimensional structures from OCA and Proteopedia for ALOX15 Gene

    Alternative splice isoforms for ALOX15 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ALOX15 Gene

Proteomics data for ALOX15 Gene at MOPED

Post-translational modifications for ALOX15 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ALOX15 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Domains for ALOX15 Gene

Gene Families for ALOX15 Gene

HGNC:
  • ALOX :Arachidonate lipoxygenases
IUPHAR :

Suggested Antigen Peptide Sequences for ALOX15 Gene

Graphical View of Domain Structure for InterPro Entry

P16050

UniProtKB/Swiss-Prot:

LOX15_HUMAN
Domain:
  • The PLAT domain can bind calcium ions; this promotes association with membranes.:
    • P16050
  • Contains 1 lipoxygenase domain.:
    • P16050
  • Contains 1 PLAT domain.:
    • P16050
Family:
  • Belongs to the lipoxygenase family.:
    • P16050
genes like me logo Genes that share domains with ALOX15: view

Function for ALOX15 Gene

Molecular function for ALOX15 Gene

GENATLAS Biochemistry: arachidonate-15-lipoxygenase,lipid peroxidating enzyme implicated in the pathogenesis of inflammatory disorders as well as membrane remodeling,carcinogenesis,and atheroma formation,upregulated by mutant TP53 and maybe involved in the development of prostate or colorectal carcinomas
UniProtKB/Swiss-Prot CatalyticActivity: Arachidonate + O(2) = (5Z,8Z,10E,14Z)-(12S)-12-hydroperoxyicosa-5,8,10,14-tetraenoate
UniProtKB/Swiss-Prot CatalyticActivity: Arachidonate + O(2) = (5Z,8Z,11Z,13E)-(15S)-15-hydroperoxyicosa-5,8,11,13-tetraenoate
UniProtKB/Swiss-Prot EnzymeRegulation: Activity is increased by binding phosphatidylinositol phosphates, especially phosphatidylinositol 3,4-bisphosphate and phosphatidylinositol 4,5-bisphosphate.
UniProtKB/Swiss-Prot Function: Non-heme iron-containing dioxygenase that catalyzes the stereo-specific peroxidation of free and esterified polyunsaturated fatty acids generating a spectrum of bioactive lipid mediators. Converts arachidonic acid into 12-hydroperoxyeicosatetraenoic acid/12-HPETE and 15-hydroperoxyeicosatetraenoic acid/15-HPETE. Also converts linoleic acid to 13-hydroperoxyoctadecadienoic acid. May also act on (12S)-hydroperoxyeicosatetraenoic acid/(12S)-HPETE to produce hepoxilin A3. Probably plays an important role in the immune and inflammatory responses. Through the oxygenation of membrane-bound phosphatidylethanolamine in macrophages may favor clearance of apoptotic cells during inflammation by resident macrophages and prevent an autoimmune response associated with the clearance of apoptotic cells by inflammatory monocytes. In parallel, may regulate actin polymerization which is crucial for several biological processes, including macrophage function. May also regulate macrophage function through regulation of the peroxisome proliferator activated receptor signaling pathway. Finally, it is also involved in the cellular response to IL13/interleukin-13. In addition to its role in the immune and inflammatory responses, may play a role in epithelial wound healing in the cornea maybe through production of lipoxin A4. May also play a role in endoplasmic reticulum stress response and the regulation of bone mass.
UniProtKB/Swiss-Prot Induction: Up-regulated by UV-irradiation.

Enzyme Numbers (IUBMB) for ALOX15 Gene

Gene Ontology (GO) - Molecular Function for ALOX15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004052 arachidonate 12-lipoxygenase activity IDA 1944593
GO:0005506 iron ion binding ISS --
GO:0005515 protein binding IPI 21831839
GO:0005546 phosphatidylinositol-4,5-bisphosphate binding IDA 17052953
GO:0016702 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen --
genes like me logo Genes that share ontologies with ALOX15: view
genes like me logo Genes that share phenotypes with ALOX15: view

Animal Models for ALOX15 Gene

MGI Knock Outs for ALOX15:

No data available for miRNA , Transcription Factor Targeting and HOMER Transcription for ALOX15 Gene

Localization for ALOX15 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ALOX15 Gene

Cytoplasm, cytosol. Cell membrane; Peripheral membrane protein. Lipid droplet. Note=Predominantly cytosolic; becomes enriched at membranes upon calcium binding. Translocates from the cytosol to the plasma membrane when stimulated by IL13/interleukin-13 and in macrophages binding apoptotic cells.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ALOX15 Gene COMPARTMENTS Subcellular localization image for ALOX15 gene
Compartment Confidence
cytosol 4
nucleus 4
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for ALOX15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm --
GO:0005811 lipid particle IDA 19528634
GO:0005829 cytosol TAS --
GO:0005886 plasma membrane ISS --
GO:0016020 membrane IDA 21831839
genes like me logo Genes that share ontologies with ALOX15: view

Pathways for ALOX15 Gene

genes like me logo Genes that share pathways with ALOX15: view

UniProtKB/Swiss-Prot P16050-LOX15_HUMAN

  • Pathway: Lipid metabolism; hydroperoxy eicosatetraenoic acid biosynthesis

Interacting Proteins for ALOX15 Gene

Gene Ontology (GO) - Biological Process for ALOX15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001503 ossification ISS --
GO:0002820 negative regulation of adaptive immune response ISS --
GO:0006646 phosphatidylethanolamine biosynthetic process ISS --
GO:0006691 leukotriene metabolic process TAS --
GO:0006954 inflammatory response TAS 10200270
genes like me logo Genes that share ontologies with ALOX15: view

Compounds for ALOX15 Gene

(5) Tocris Compounds for ALOX15 Gene

Compound Action Cas Number
Baicalein 5- and 12-Lipoxygenase inhibitor [491-67-8]
BAY-X 1005 Orally active 5-lipoxygenase activating protein (FLAP) inhibitor [128253-31-6]
BW-B 70C 5-Lipoxygenase inhibitor [134470-38-5]
MK 886 Inhibitor of 5-lipoxygenase-activating protein (FLAP) [118414-82-7]
Zileuton Orally active 5-LOX inhibitor [111406-87-2]

(7) HMDB Compounds for ALOX15 Gene

Compound Synonyms Cas Number PubMed IDs
13-L-Hydroperoxylinoleic acid
  • (13S,9z,11e)-13-hydroperoxy-9,11-octadecadienoic acid
33964-75-9
15(S)-HPETE
  • (5Z,8Z,11Z,13E)-(15S)-15-Hydroperoxyicosa-5,8,11,13-tetraenoate
70981-96-3
9(S)-HPODE
Not Available
Arachidonic acid
  • 5,8,11,14-Eicosatetraenoic acid
506-32-1
Iron
  • Armco iron
7439-89-6

(1) Drugbank Compounds for ALOX15 Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
(2E)-3-(2-OCT-1-YN-1-YLPHENYL)ACRYLIC ACID
target

(19) Novoseek inferred chemical compound relationships for ALOX15 Gene

Compound -log(P) Hits PubMed IDs
(13s)-hydroxyoctadecadienoic acid 90.9 3
15hpete 82.5 2
15-hydroxyeicosatetraenoic acid 81.6 5
arachidonic acid 79.9 35
13-hpode 73.9 4
genes like me logo Genes that share compounds with ALOX15: view

Transcripts for ALOX15 Gene

Unigene Clusters for ALOX15 Gene

Arachidonate 15-lipoxygenase:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ALOX15 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10
SP1:
SP2:
SP3:
SP4:
SP5:

Relevant External Links for ALOX15 Gene

GeneLoc Exon Structure for
ALOX15
ECgene alternative splicing isoforms for
ALOX15

Expression for ALOX15 Gene

mRNA expression in normal human tissues for ALOX15 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ALOX15 Gene

This gene is overexpressed in Adipose - Visceral (Omentum) (26.7) and Heart - Atrial Appendage (4.6).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for ALOX15 Gene

SOURCE GeneReport for Unigene cluster for ALOX15 Gene Hs.73809

mRNA Expression by UniProt/SwissProt for ALOX15 Gene

P16050-LOX15_HUMAN
Tissue specificity: Detected in monocytes and eosinophils (at protein level). Expressed in airway epithelial cells.
genes like me logo Genes that share expressions with ALOX15: view

Orthologs for ALOX15 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ALOX15 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ALOX15 35
  • 99.45 (n)
  • 99.7 (a)
ALOX15 36
  • 96 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ALOX12 36
  • 87 (a)
OneToOne
ALOX15 35
  • 86.86 (n)
  • 86.4 (a)
dog
(Canis familiaris)
Mammalia ALOX15 35
  • 84.29 (n)
  • 84.29 (a)
ALOX15 36
  • 81 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Alox15 35
  • 77.79 (n)
  • 73.72 (a)
Alox15 16
Alox15 36
  • 74 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ALOX15 36
  • 56 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 67 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Alox15 35
  • 78.5 (n)
  • 74.62 (a)
zebrafish
(Danio rerio)
Actinopterygii alox12 36
  • 44 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 27 (a)
ManyToMany
-- 36
  • 29 (a)
ManyToMany
-- 36
  • 27 (a)
ManyToMany
CSA.6148 36
  • 27 (a)
ManyToMany
Species with no ortholog for ALOX15:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ALOX15 Gene

ENSEMBL:
Gene Tree for ALOX15 (if available)
TreeFam:
Gene Tree for ALOX15 (if available)

Paralogs for ALOX15 Gene

Paralogs for ALOX15 Gene

Selected SIMAP similar genes for ALOX15 Gene using alignment to 5 proteins:

Pseudogenes.org Pseudogenes for ALOX15 Gene

genes like me logo Genes that share paralogs with ALOX15: view

Variants for ALOX15 Gene

Sequence variations from dbSNP and Humsavar for ALOX15 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
rs743646 -- 4,632,946(-) AAGAC(A/G)GACGT reference, synonymous-codon
rs762743 -- 4,638,502(-) AAAGA(A/T)GCAGG intron-variant
rs899452 -- 4,638,449(-) CAAGG(A/G)GGCAT intron-variant
rs916055 -- 4,631,539(-) CTTCG(C/T)GGTTA utr-variant-3-prime
rs916056 -- 4,631,375(-) tcctt(C/G)ctctc utr-variant-3-prime

Relevant External Links for ALOX15 Gene

HapMap Linkage Disequilibrium report
ALOX15
Human Gene Mutation Database (HGMD)
ALOX15

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for ALOX15 Gene

Disorders for ALOX15 Gene

UniProtKB/Swiss-Prot

LOX15_HUMAN
  • Note=Disease susceptibility may be associated with variations affecting the gene represented in this entry. Met at position 560 may confer interindividual susceptibility to coronary artery disease (CAD) (PubMed:17959182). {ECO:0000269 PubMed:17959182}.

(11) Novoseek inferred disease relationships for ALOX15 Gene

Disease -log(P) Hits PubMed IDs
atherosclerosis 45.9 8
inflammation 36.1 5
colorectal cancer 20.8 1
asthma 20.8 4
rheumatoid arthritis 12.9 1

Relevant External Links for ALOX15

Genetic Association Database (GAD)
ALOX15
Human Genome Epidemiology (HuGE) Navigator
ALOX15
genes like me logo Genes that share disorders with ALOX15: view

Publications for ALOX15 Gene

  1. A near null variant of 12/15-LOX encoded by a novel SNP in ALOX15 and the risk of coronary artery disease. (PMID: 17959182) Assimes T.L. … Quertermous T. (Atherosclerosis 2008) 3 4 23 48
  2. 15-Lipoxygenase gene variants are associated with carotid plaque but not carotid intima-media thickness. (PMID: 18392641) McCaskie P.A. … Palmer L.J. (Hum. Genet. 2008) 3 23 48
  3. The c.-292C>T promoter polymorphism increases reticulocyte-type 15-lipoxygenase-1 activity and could be atheroprotective. (PMID: 17439326) Wittwer J. … Hersberger M. (Clin. Chem. Lab. Med. 2007) 3 23 48
  4. Reciprocal regulation of 12- and 15-lipoxygenases by UV-irradiation in human keratinocytes. (PMID: 18755188) Yoo H. … Kim T.Y. (FEBS Lett. 2008) 3 4 23
  5. Variation in eicosanoid genes, non-fatal myocardial infarction and ischemic stroke. (PMID: 19046748) Lemaitre R.N. … Psaty B.M. (Atherosclerosis 2009) 3 23 48

Products for ALOX15 Gene

Sources for ALOX15 Gene

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