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ALOX15 Gene

protein-coding GIFtS: 68

GC17M004480

arachidonate 15-lipoxygenase
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
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Aliases
15-LOX ^³
15-LOX-1 ^¹, ²
15-LOX2 ^²
EC 1.13.11.33 ^³
LOG15 ^³

Descriptions
Arachidonate omega-6 lipoxygenase ^³
arachidonate 15-lipoxygenase ^²

External Ids
HGNC: 433¹
Entrez Gene: 246²
UniProtKB: P16050³
Ensembl: ENSG00000161905⁷

Search outside databases for aliases for ALOX15 gene

Previous GC identifers: GC17M004960 GC17M004879 GC17M004485 GC17M004740

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: LOX15_HUMAN, P16050

Function: Converts arachidonic acid to 15S-hydroperoxyeicosatetraenoic acid. Also acts on C-12 of

arachidonate as well as on linoleic acid

Gene Wiki entry for ALOX15

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the ALOX15 gene

Entrez Gene cytogenetic band: 17p13.3 Ensembl cytogenetic band: 17p13.2 HGNC cytogenetic band: 17p13.3

ALOX15 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 17 GeneLoc Exon Structure

GeneLoc location for GC17M004480: (about GC identifiers)

Start:	4,480,963 bp from pter
End:	4,491,709 bp from pter
Size:	10,747 bases
Orientation:	minus strand

RefSeq DNA sequence:

NC_000017.9 NT_010718.15

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: LOX15_HUMAN, P16050 (See protein sequence)

Recommended Name: Arachidonate 15-lipoxygenase

Size: 662 amino acids; 74804 Da

Cofactor: Binds 1 iron ion per subunit (By similarity)

Subcellular location: Cytoplasm

PDB structures from and Proteopedia :

2ABT (3D)

Secondary accessions: A8K2P4 Q8N6R7 Q99657

Post-translational modifications:

View phosphorylation sites using PhosphoSite²

REFSEQ proteins: NP_001131.3

ENSEMBL proteins:

ENSP00000293761

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Enzo Life Sciences proteins for ALOX15
	Recombinant Proteins from Abcam (15 Lipoxygenase 1)
	Human Recombinant Proteins from Abnova (ALOX15)

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

2 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005737	cytoplasm	IEA	--
GO:0005829	cytosol	IEA	--

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Antibodies for ALOX15:

	Browse Antibodies Central at Invitrogen
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Sigma-Aldrich Antibodies for ALOX15
	Browse R&D Systems for Antibodies
	Antibodies from Abcam (15 Lipoxygenase 1), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (ALOX15)
	Novus Biologicals Antibody for ALOX15

Assays for ALOX15:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry P16050

ProtoNet protein and cluster: P16050

3 Blocks protein families:

IPB000907 Lipoxygenase

IPB001024 Lipoxygenase

IPB001885 Mammalian lipoxygenase signature

UniProtKB/Swiss-Prot: LOX15_HUMAN, P16050

Similarity: Belongs to the lipoxygenase family

Similarity: Contains 1 lipoxygenase domain

Similarity: Contains 1 PLAT domain

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (ALOX15)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (ALOX15)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_001140

Applied Biosystems Silencer® siRNAs for ALOX15

Sigma-Aldrich siRNA and siRNA Panels for ALOX15

Sigma-Aldrich shRNA for ALOX15

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for ALOX15
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_001140
Myc/DDK tagged cDNA clone in CMV expression vector: NM_001140
untagged cDNA clones in CMV expression vector (see all 3): NM_001140

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_001140

UniProtKB/Swiss-Prot: LOX15_HUMAN, P16050

Function: Converts arachidonic acid to 15S-hydroperoxyeicosatetraenoic acid. Also acts on C-12 of

arachidonate as well as on linoleic acid

Catalytic activity: Arachidonate + O(2) =

(5Z,8Z,11Z,13E)-(15S)-15-hydroperoxyicosa-5,8,11,13-tetraenoate

Enzyme Number (IUBMB): EC 1.13.11.33

Genatlas biochemistry entry for ALOX15:

arachidonate-15-lipoxygenase,lipid peroxidating enzyme implicated in the pathogenesis of

inflammatory disorders as well as membrane remodeling,carcinogenesis,and atheroma

formation,upregulated by mutant TP53 and maybe involved in the development of prostate or

colorectal carcinomas

7 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Alox15):

endocrine/exocrine gland	hematopoietic system	immune system	life span-post-weaning/aging	reproductive system
skin/coat/nails	tumorigenesis

5/6 Gene Ontology (GO) molecular function terms (links to tree view) (see all 6 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005506	iron ion binding	IEA	--
GO:0016165	lipoxygenase activity	TAS	3202857
GO:0016491	oxidoreductase activity	IEA	--
GO:0046872	metal ion binding	IEA	--
GO:0047977	hepoxilin-epoxide hydrolase activity	IEA	--

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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5/8 Sigma-Aldrich "Your Favorite Gene" Pathways for ALOX15 (Your Favorite Gene powered by Ingenuity) (see all 8 )

Docosahexaenoic Acid (DHA) Signaling
Aminosugars Metabolism
Eicosanoid Signaling
Linoleic Acid Metabolism
Arachidonic Acid Metabolism

GeneDecks ALOX15 for the pathways selected above

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UniProtKB/Swiss-Prot: LOX15_HUMAN, P16050

Pathway: Lipid metabolism; leukotriene D4 biosynthesis

Gene Network Central^TM Interacting Genes and Proteins Network for ALOX15

5/52 Interacting proteins for ALOX15 (ENSP00000293761³) via UniProtKB, MINT, and/or STRING (see all 52 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
PTGS2	ENSP00000356438³	STRING (score=.961)
STAT6	ENSP00000300134³	STRING (score=.958)
PLA2G1B	ENSP00000312286³	STRING (score=.949)
GPX4	ENSP00000346103³	STRING (score=.942)
PTGS1	ENSP00000354612³	STRING (score=.941)

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5 Gene Ontology (GO) biological process terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006629	lipid metabolic process	NAS	3202857
GO:0006954	inflammatory response	TAS	10200270
GO:0019370	leukotriene biosynthetic process	IEA	--
GO:0030282	bone mineralization	IEA	--
GO:0055114	oxidation reduction	IEA	--

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Enzo Life Sciences drugs & compounds for ALOX15

Sigma-Aldrich Small Molecules for ALOX15:

Inhibitor

Compounds for ALOX15 available from Tocris Bioscience

Compound	Action	CAS number
2-TEDC	5-, 12-, 15-Lipoxygenase inhibitor	[132465-10-2]
PD 146176	Selective 15-lipoxygenase inhibitor	[4079-26-9]

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10/15 Novoseek chemical compound relationships for ALOX15 gene (see all 15 )

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
(13s)-hydroxyoctadecadienoic acid	89.85	4	10506115 (1), 12510822 (1)
15hpete	83.55	2	17305569 (1), 10332966 (1)
arachidonic acid	80.08	48	1662607 (2), 8195716 (2), 16598376 (2), 10332966 (2) (see all 28)
15-hydroxyeicosatetraenoic acid	79.94	6	10332966 (3), 17519227 (1)
13-hpode	75.39	7	10400618 (4)
linoleic acid	61.66	5	10506115 (1), 9931410 (1), 12510822 (1), 17869078 (1)
fatty acid	22.26	1	9931410 (1)
phosphatidylethanolamine	20.62	3	17519227 (1)
lipid	16.42	4	10400618 (2), 1729692 (1), 17918787 (1)
histidine	3.95	1	10625675 (1)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (ALOX15)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (ALOX15)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_001140

Sigma-Aldrich siRNA and siRNA Panels for ALOX15

Sigma-Aldrich shRNA for ALOX15

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_001140

REFSEQ mRNAs for ALOX15 gene:

NM_001140.3

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_001140

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_001140
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_001140
                                 untagged cDNA clones in CMV expression vector (see all 3): NM_001140

Additional cDNA sequence:

AK290309.1 AK296792.1 AK296821.1 AK296904.1 AK312557.1 AK316126.1 BC029032.1 M23892.1

3 DOTS entries:

DT.100020039 DT.120922324 DT.121002907

23 AceView cDNA sequences:

NM_001140 BM976589 BQ957032 BX282722 BX113915 M23892 BM975623 CB305636

BM975468 BC029032 BM981991 AU119118 CA436179 CA311119 BQ276406 BI823909

BX644955 BV196138 BE538114 CA405412 AI864921 BU935146 CN478760

highest scoring ESTs for ALOX15:

M23892 BC029032 BI823909 BQ957032 BX282722 BX644955 AI864921 BQ276406 CN258952 NM_001140

Unigene Cluster for ALOX15:

Arachidonate 15-lipoxygenase

Hs.73809 [show with all ESTs]

Unigene Representative Sequence: NM_001140

GeneLoc Exon Structure

5 Alternative Splicing Database (ASD) splice patterns (SP) for ALOX15

ExUns:	1a	·	1b	^	2	^	3	^	4a	·	4b	^	5	^	6	^	7	^	8a	·	8b	^	9	^	10
SP1:
SP2:
SP3:
SP4:
SP5:

About this scheme

ECgene alternative splicing isoforms for ALOX15

1 Ensembl transcript including schematic representation:

ENST00000293761

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

ALOX15 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for ALOX15

¹ / ² / ³

3 probe-sets matching ALOX15 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
34636_at²^{, 3}	U95-A	1	1.00	1.00	1.00	1.00	M23892	1.00	1.00	1.00	1
207328_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_001140	0.60	1.00	0.82	1
207328_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

GeneDecks ALOX15 for binary patterns associated with the probe-sets selected above

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Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: TGTATCTTCA

SOURCE GeneReport for Unigene cluster: Hs.73809
Expression variation in blood from EXPOLDB for ALOX15

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for ALOX15 gene from 5 species

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	ALOX15¹	--	arachidonate 15-lipoxygenase	84.29(n) 84.29(a)	489458 XM_546576.2 XP_546576.2
chimpanzee (Pan troglodytes)	ALOX15¹	--	arachidonate 15-lipoxygenase	99.45(n) 99.7(a)	748294 XM_001160792.1 XP_001160792.1
cow (Bos taurus)	ALOX15¹	--	arachidonate 15-lipoxygenase	86.86(n) 86.4(a)	282139 NM_174501.2 NP_776926.1
rat (Rattus norvegicus)	Alox15¹	--	arachidonate 15-lipoxygenase	78.5(n) 74.62(a)	81639 NM_031010.2 NP_112272.2
mouse (Mus musculus)	Alox15^{1, 5}	11 (40.00 cM)⁵	arachidonate 15-lipoxygenase^{1, 5}	77.79(n)¹ 73.72(a)¹	11687¹ NM_009660.3¹ NP_033790.3¹ AK142371⁵ AL596096⁵ (see all 12)

About this table Species with no ortholog for ALOX15

ENSEMBL Gene Tree for ALOX15

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for ALOX15 gene

ALOX12P2² ALOX15B² ALOX12²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/206 NCBI SNPs in ALOX15 are shown (see all 206 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 37)

AB	SNP ID	Valid	Chr 17 pos	Sequence	Recs	AA Chg	Type	More	Recs	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--			--
	rs916055^1,2	A,C,F,H,O	4481583(-)	`CTTCGT/CGGTTA`	1	--	ut3¹		17	MN NS NA EU EA WA	1464
	rs2664593^1,2	A,C,F,H,O	4491881(-)	`ACTGGG/CGCTGA`	1	--	ng3¹		17	PA NS EU EA WA MN CSAM NA	3596
	rs2255888^1,2	A,C,F,H	4492330(+)	`TGTTGT/CCTGCA`	1	--	ng3¹		20	PA NS MN CSAM EA EU WA	4582
	rs2664592^1,2	A,C,F,H	4491912(-)	`TCCCTG/CCTCTC`	1	--	ng3¹		19	PA NS EU EA WA MN CSAM NA	3828
--	rs7220870^1,2	A,C,F	4491967(+)	`TGGACC/AGAAAA`	1	--	ng3¹		9	NS MN CSAM EA NA	630
	rs11568131^1,2	C,F,H	4481357(-)	`TAAATC/TATTTC`	1	--	ut3¹ ese³		11	NS EU EA WA NA	966
	rs8064788^1,2	C,F,H	4493396(+)	`GTCCAG/CGAAAA`	1	--	ng3¹		4	EU EA WA	420
--	rs12709338^1,2	C,F	4492014(-)	`ACCTCG/TCCTGC`	1	--	ng3¹		2	NA	144
--	rs7221063^1,2	C,F	4492122(+)	`ACACAC/TGCAAG`	1	--	ng3¹		2	NS	82
--	rs3892408^1,2	C,F	4488353(+)	`CACCAC/TGGGGT`	1	V/M	mis¹		1	NA	48

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HapMap Linkage Disequilibrium images for ALOX15 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 152392

10/11 Novoseek disease relationships for ALOX15 gene (see all 11 )

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
atherosclerosis	46.80	10	17869078 (2), 18000963 (1), 17439326 (1), 18392641 (1) (see all 7)
inflammation	34.49	5	14740455 (1), 17439326 (1), 17164146 (1), 17869078 (1)
colorectal cancer	24.15	1	14566836 (1)
asthma	19.42	3	17439326 (1), 16320347 (1), 8358018 (1)
rheumatoid arthritis	16.08	1	10332966 (1)
arthritis	15.80	2	17439326 (1), 16320347 (1)
prostate cancer	13.31	1	15850718 (1)
osteoporosis	5.83	1	16799083 (1)
cancer	0.00	1	15519529 (1)
tumors	0.00	2	14740455 (1)

About this table

Human Gene Mutation Database: ALOX15
Genetic Association Database: ALOX15
Human Genome Epidemiology Navigator: ALOX15 (14 documents)

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/154 PubMed articles for ALOX15 gene (see all 154 ):

Purification of two forms of arachidonate 15-lipoxygenase from human leukocytes. (PubMed id 1662607)^{1, 3, 4} Izumi T.... Samuelsson B. (1991)
Association of a single nucleotide polymorphism in the lipoxygenase ALOX15 5'-flanking region (-5229G/A) with bone mineral density. (PubMed id 15838625)^{1, 3, 6} Urano T....Inoue S. (2005)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)
Human 15-lipoxygenase gene promoter: analysis and identification of DNA binding sites for IL-13-induced regulatory factors in monocytes. (PubMed id 9700053)^{3, 4} Kelavkar U.... Badr K. (1998)
Characterization and sequence of an additional 15-lipoxygenase transcript and of the human gene. (PubMed id 9224951)^{3, 4} Kritzik M.R....Sigal E. (1997)
Characterization of human 12-lipoxygenase genes. (PubMed id 1570320)^{2, 3} Funk C.D.... Samuelsson B. (1992)
A primary determinant for lipoxygenase positional specificity. (PubMed id 1944593)^{3, 4} Sloane D.L.... Sigal E. (1991)
Molecular cloning and primary structure of human 15-lipoxygenase. (PubMed id 3202857)^{3, 4} Sigal E.... Nadel J.A. (1988)
Arachidonate 15-lipoxygenase (omega-6 lipoxygenase) from human leukocytes. Purification and structural homology to other mammalian lipoxygenases. (PubMed id 3356688)^{3, 4} Sigal E.... Nadel J.A. (1988)
Human ALOX12, but not ALOX15, is associated with BMD in white men and women. (PubMed id 16598376)^{1, 3} Ichikawa S....Econs M.J. (2006)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 246	HGNC: 433	AceView: ALOX15	Ensembl:ENSG00000161905	euGenes: HUgn246
ECgene: ALOX15	H-InvDB: ALOX15

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
ATLAS Chromosomes in Cancer entry for ALOX15	Genetics and Cytogenetics in Oncology and Haematology
SeattleSNPs	http://pga.gs.washington.edu/data/alox15/

Licensable Technologies for ALOX15
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for ALOX15:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for ALOX15-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for ALOX15		Antibodies for ALOX15
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for ALOX15		Small molecules for ALOX15
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Recombinant Proteins (ALOX15)
	Antibodies (ALOX15)
	Chimera RNAi (ALOX15)
	Custom Service for Mouse Mab
	Custom Service for Rabbit Pab from Full-length Protein

Search for Antibodies & Assays

	Recombinant Proteins (15 Lipoxygenase 1)
	Antibodies (15 Lipoxygenase 1)

Search OriGene for ALOX15

Tocris compounds for ALOX15

	Drugs/Proteins for ALOX15
	Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Antibodies for ALOX15

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ALOX15 Gene

protein-coding GIFtS: 68

Aliases &
Descriptions
for ALOX15

Summaries
for ALOX15

Genomic Location
for ALOX15

Proteins
for ALOX15

Protein Domains/
Families
for ALOX15

Gene Function
for ALOX15

Pathways & Interactions
for ALOX15

Drugs & Compounds
for ALOX15

Transcripts
for ALOX15

Expression
for ALOX15

Orthologs
for ALOX15

Paralogs
for ALOX15

SNPs/Variants
for ALOX15

Disorders & Mutations
for ALOX15

Medical News
for ALOX15

Publications
for ALOX15

Search for ALOX15

Genome Databases showing ALOX15

Other Databases showing ALOX15

Specialized Databases showing ALOX15

Licensable Technologies
for ALOX15

Services
for ALOX15

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

ALOX15 Gene

protein-coding GIFtS: 68

Aliases & Descriptionsfor ALOX15

Summariesfor ALOX15

Genomic Locationfor ALOX15

Proteinsfor ALOX15

Protein Domains/Familiesfor ALOX15

Gene Functionfor ALOX15

Pathways & Interactionsfor ALOX15

Drugs & Compoundsfor ALOX15

Transcriptsfor ALOX15

Expression for ALOX15

Orthologsfor ALOX15

Paralogsfor ALOX15

SNPs/Variantsfor ALOX15

Disorders & Mutationsfor ALOX15

Medical Newsfor ALOX15

Publicationsfor ALOX15

Search for ALOX15

Genome Databases showing ALOX15

Other Databases showing ALOX15

Specialized Databases showing ALOX15

Licensable Technologiesfor ALOX15

Servicesfor ALOX15

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for ALOX15

Summaries
for ALOX15

Genomic Location
for ALOX15

Proteins
for ALOX15

Protein Domains/
Families
for ALOX15

Gene Function
for ALOX15

Pathways & Interactions
for ALOX15

Drugs & Compounds
for ALOX15

Transcripts
for ALOX15

Expression
for ALOX15

Orthologs
for ALOX15

Paralogs
for ALOX15

SNPs/Variants
for ALOX15

Disorders & Mutations
for ALOX15

Medical News
for ALOX15

Publications
for ALOX15

Licensable Technologies
for ALOX15

Services
for ALOX15