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Aliases for ALOX15 Gene

Aliases for ALOX15 Gene

  • Arachidonate 15-Lipoxygenase 2 3 5
  • Arachidonate 12-Lipoxygenase, Leukocyte-Type 3 4
  • Arachidonate Omega-6 Lipoxygenase 3 4
  • 12/15-Lipoxygenase 3 4
  • 15-LOX-1 3 4
  • 12-LOX 3 4
  • 15-LOX 3 4
  • 15-Lipooxygenase-1 3
  • EC 1.13.11.33 4
  • EC 1.13.11.31 4
  • EC 1.13.11 63
  • 15LOX-1 3
  • LOG15 4

External Ids for ALOX15 Gene

Previous GeneCards Identifiers for ALOX15 Gene

  • GC17M004960
  • GC17M004879
  • GC17M004485
  • GC17M004740
  • GC17M004480
  • GC17M004534

Summaries for ALOX15 Gene

GeneCards Summary for ALOX15 Gene

ALOX15 (Arachidonate 15-Lipoxygenase) is a Protein Coding gene. Diseases associated with ALOX15 include leukomalacia and artery disease. Among its related pathways are Metabolism and Arachidonic acid metabolism. GO annotations related to this gene include iron ion binding and oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen. An important paralog of this gene is ALOX5.

UniProtKB/Swiss-Prot for ALOX15 Gene

  • Non-heme iron-containing dioxygenase that catalyzes the stereo-specific peroxidation of free and esterified polyunsaturated fatty acids generating a spectrum of bioactive lipid mediators. Converts arachidonic acid into 12-hydroperoxyeicosatetraenoic acid/12-HPETE and 15-hydroperoxyeicosatetraenoic acid/15-HPETE. Also converts linoleic acid to 13-hydroperoxyoctadecadienoic acid. May also act on (12S)-hydroperoxyeicosatetraenoic acid/(12S)-HPETE to produce hepoxilin A3. Probably plays an important role in the immune and inflammatory responses. Through the oxygenation of membrane-bound phosphatidylethanolamine in macrophages may favor clearance of apoptotic cells during inflammation by resident macrophages and prevent an autoimmune response associated with the clearance of apoptotic cells by inflammatory monocytes. In parallel, may regulate actin polymerization which is crucial for several biological processes, including macrophage function. May also regulate macrophage function through regulation of the peroxisome proliferator activated receptor signaling pathway. Finally, it is also involved in the cellular response to IL13/interleukin-13. In addition to its role in the immune and inflammatory responses, may play a role in epithelial wound healing in the cornea maybe through production of lipoxin A4. May also play a role in endoplasmic reticulum stress response and the regulation of bone mass.

Tocris Summary for ALOX15 Gene

  • Lipoxygenases (LOXs) are a family of non-heme iron dioxygenases that are involved in the production and metabolism of fatty acid hydroperoxidases. There are six lipoxygenase isozymes; 5-LOX, 12R-LOX, 12S-LOX, 15-LOX-1, 15-LOX-2 and E-LOX.

Gene Wiki entry for ALOX15 Gene

No data available for Entrez Gene Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ALOX15 Gene

Genomics for ALOX15 Gene

Regulatory Elements for ALOX15 Gene

Promoters for ALOX15 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around ALOX15 on UCSC Golden Path with GeneCards custom track

Genomic Location for ALOX15 Gene

Chromosome:
17
Start:
4,630,902 bp from pter
End:
4,642,294 bp from pter
Size:
11,393 bases
Orientation:
Minus strand

Genomic View for ALOX15 Gene

Genes around ALOX15 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ALOX15 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ALOX15 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ALOX15 Gene

Proteins for ALOX15 Gene

  • Protein details for ALOX15 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P16050-LOX15_HUMAN
    Recommended name:
    Arachidonate 15-lipoxygenase
    Protein Accession:
    P16050
    Secondary Accessions:
    • A8K2P4
    • B7ZA11
    • Q8N6R7
    • Q99657

    Protein attributes for ALOX15 Gene

    Size:
    662 amino acids
    Molecular mass:
    74804 Da
    Cofactor:
    Name=Fe cation; Xref=ChEBI:CHEBI:24875;
    Quaternary structure:
    • Interacts with PEBP1; in response to IL13/interleukin-13, prevents the interaction of PEBP1 with RAF1 to activate the ERK signaling cascade.

    Three dimensional structures from OCA and Proteopedia for ALOX15 Gene

    Alternative splice isoforms for ALOX15 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ALOX15 Gene

Proteomics data for ALOX15 Gene at MOPED

Post-translational modifications for ALOX15 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ALOX15 Gene

Antibody Products

Domains & Families for ALOX15 Gene

Gene Families for ALOX15 Gene

Suggested Antigen Peptide Sequences for ALOX15 Gene

Graphical View of Domain Structure for InterPro Entry

P16050

UniProtKB/Swiss-Prot:

LOX15_HUMAN :
  • The PLAT domain can bind calcium ions; this promotes association with membranes.
  • Belongs to the lipoxygenase family.
Domain:
  • The PLAT domain can bind calcium ions; this promotes association with membranes.
  • Contains 1 lipoxygenase domain.
  • Contains 1 PLAT domain.
Family:
  • Belongs to the lipoxygenase family.
genes like me logo Genes that share domains with ALOX15: view

Function for ALOX15 Gene

Molecular function for ALOX15 Gene

GENATLAS Biochemistry:
arachidonate-15-lipoxygenase,lipid peroxidating enzyme implicated in the pathogenesis of inflammatory disorders as well as membrane remodeling,carcinogenesis,and atheroma formation,upregulated by mutant TP53 and maybe involved in the development of prostate or colorectal carcinomas
UniProtKB/Swiss-Prot CatalyticActivity:
Arachidonate + O(2) = (5Z,8Z,10E,14Z)-(12S)-12-hydroperoxyicosa-5,8,10,14-tetraenoate.
UniProtKB/Swiss-Prot CatalyticActivity:
Arachidonate + O(2) = (5Z,8Z,11Z,13E)-(15S)-15-hydroperoxyicosa-5,8,11,13-tetraenoate.
UniProtKB/Swiss-Prot EnzymeRegulation:
Activity is increased by binding phosphatidylinositol phosphates, especially phosphatidylinositol 3,4-bisphosphate and phosphatidylinositol 4,5-bisphosphate.
UniProtKB/Swiss-Prot Function:
Non-heme iron-containing dioxygenase that catalyzes the stereo-specific peroxidation of free and esterified polyunsaturated fatty acids generating a spectrum of bioactive lipid mediators. Converts arachidonic acid into 12-hydroperoxyeicosatetraenoic acid/12-HPETE and 15-hydroperoxyeicosatetraenoic acid/15-HPETE. Also converts linoleic acid to 13-hydroperoxyoctadecadienoic acid. May also act on (12S)-hydroperoxyeicosatetraenoic acid/(12S)-HPETE to produce hepoxilin A3. Probably plays an important role in the immune and inflammatory responses. Through the oxygenation of membrane-bound phosphatidylethanolamine in macrophages may favor clearance of apoptotic cells during inflammation by resident macrophages and prevent an autoimmune response associated with the clearance of apoptotic cells by inflammatory monocytes. In parallel, may regulate actin polymerization which is crucial for several biological processes, including macrophage function. May also regulate macrophage function through regulation of the peroxisome proliferator activated receptor signaling pathway. Finally, it is also involved in the cellular response to IL13/interleukin-13. In addition to its role in the immune and inflammatory responses, may play a role in epithelial wound healing in the cornea maybe through production of lipoxin A4. May also play a role in endoplasmic reticulum stress response and the regulation of bone mass.
UniProtKB/Swiss-Prot Induction:
Up-regulated by UV-irradiation.

Enzyme Numbers (IUBMB) for ALOX15 Gene

Gene Ontology (GO) - Molecular Function for ALOX15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0046872 metal ion binding IEA --
GO:0051120 hepoxilin A3 synthase activity IEA --
genes like me logo Genes that share ontologies with ALOX15: view
genes like me logo Genes that share phenotypes with ALOX15: view

Animal Models for ALOX15 Gene

MGI Knock Outs for ALOX15:

Animal Model Products

CRISPR Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ALOX15 Gene

Localization for ALOX15 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ALOX15 Gene

Cytoplasm, cytosol. Cell membrane; Peripheral membrane protein. Lipid droplet. Note=Predominantly cytosolic; becomes enriched at membranes upon calcium binding. Translocates from the cytosol to the plasma membrane when stimulated by IL13/interleukin-13 and in macrophages binding apoptotic cells.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ALOX15 Gene COMPARTMENTS Subcellular localization image for ALOX15 gene
Compartment Confidence
cytosol 5
plasma membrane 5
mitochondrion 2
nucleus 2
peroxisome 2
extracellular 1

No data available for Gene Ontology (GO) - Cellular Components for ALOX15 Gene

Pathways & Interactions for ALOX15 Gene

genes like me logo Genes that share pathways with ALOX15: view

UniProtKB/Swiss-Prot P16050-LOX15_HUMAN

  • Pathway: Lipid metabolism; hydroperoxy eicosatetraenoic acid biosynthesis.

Interacting Proteins for ALOX15 Gene

Gene Ontology (GO) - Biological Process for ALOX15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001503 ossification ISS --
GO:0002820 negative regulation of adaptive immune response ISS --
GO:0006646 phosphatidylethanolamine biosynthetic process ISS --
GO:0019369 arachidonic acid metabolic process NAS,TAS 3202857
GO:0019372 lipoxygenase pathway TAS --
genes like me logo Genes that share ontologies with ALOX15: view

No data available for SIGNOR curated interactions for ALOX15 Gene

Drugs & Compounds for ALOX15 Gene

(8) Drugs for ALOX15 Gene - From: Novoseek, HMDB, DrugBank, and Tocris

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
arachidonic acid Experimental Nutra Activator 27
(2E)-3-(2-OCT-1-YN-1-YLPHENYL)ACRYLIC ACID Experimental Pharma Target 0
linoleic acid Pharma Full agonist, Agonist 0
Baicalein Pharma Lipoxygenases inhibitor, 5- and 12-Lipoxygenase inhibitor 0

(21) Additional Compounds for ALOX15 Gene - From: Novoseek, HMDB, and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
oxygen
  • Dioxygen
  • Molecular oxygen
  • O2
  • Oxygen
  • Oxygen molecule
7782-44-7
13-L-Hydroperoxylinoleic acid
  • (13S,9z,11e)-13-hydroperoxy-9,11-octadecadienoate
  • (13S,9z,11e)-13-hydroperoxy-9,11-octadecadienoic acid
  • (9Z,11e)-(13S)-13-hydroperoxyoctadeca-9,11-dienoate
  • (9Z,11e)-(13S)-13-hydroperoxyoctadeca-9,11-dienoic acid
  • 13(S)-Hpode
33964-75-9
15(S)-HPETE
  • (5Z,8Z,11Z,13E)-(15S)-15-Hydroperoxyicosa-5,8,11,13-tetraenoate
  • (5Z,8Z,11Z,13E)-(15S)-15-Hydroperoxyicosa-5,8,11,13-tetraenoic acid
  • 15-Hydroperoxyeicosatetraenoate
  • 15-Hydroperoxyeicosatetraenoic acid
  • 15-Hydroperoxyicosatetraenoate
70981-96-3
9(S)-HPODE
Fe2+
  • Armco iron
  • Carbonyl iron
  • FE
  • Ferrovac e
  • Hematite
15438-31-0
genes like me logo Genes that share compounds with ALOX15: view

Transcripts for ALOX15 Gene

Unigene Clusters for ALOX15 Gene

Arachidonate 15-lipoxygenase:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ALOX15 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10
SP1:
SP2:
SP3:
SP4:
SP5:

Relevant External Links for ALOX15 Gene

GeneLoc Exon Structure for
ALOX15
ECgene alternative splicing isoforms for
ALOX15

Expression for ALOX15 Gene

mRNA expression in normal human tissues for ALOX15 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ALOX15 Gene

This gene is overexpressed in Adipose - Visceral (Omentum) (x26.7) and Heart - Atrial Appendage (x4.6).

Protein differential expression in normal tissues from HIPED for ALOX15 Gene

This gene is overexpressed in Nasal epithelium (67.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ALOX15 Gene



SOURCE GeneReport for Unigene cluster for ALOX15 Gene Hs.73809

mRNA Expression by UniProt/SwissProt for ALOX15 Gene

P16050-LOX15_HUMAN
Tissue specificity: Detected in monocytes and eosinophils (at protein level). Expressed in airway epithelial cells.
genes like me logo Genes that share expression patterns with ALOX15: view

Primer Products

In Situ Assay Products

No data available for Protein tissue co-expression partners for ALOX15 Gene

Orthologs for ALOX15 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ALOX15 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ALOX15 35
  • 99.45 (n)
  • 99.7 (a)
ALOX15 36
  • 96 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ALOX12 36
  • 87 (a)
OneToOne
ALOX15 35
  • 86.86 (n)
  • 86.4 (a)
dog
(Canis familiaris)
Mammalia ALOX15 35
  • 84.29 (n)
  • 84.29 (a)
ALOX15 36
  • 81 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Alox15 16
Alox15 36
  • 74 (a)
OneToOne
Alox15 35
  • 77.79 (n)
  • 73.72 (a)
oppossum
(Monodelphis domestica)
Mammalia ALOX15 36
  • 56 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 67 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Alox15 35
  • 78.5 (n)
  • 74.62 (a)
zebrafish
(Danio rerio)
Actinopterygii alox12 36
  • 44 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 27 (a)
ManyToMany
-- 36
  • 29 (a)
ManyToMany
-- 36
  • 27 (a)
ManyToMany
CSA.6148 36
  • 27 (a)
ManyToMany
Species with no ortholog for ALOX15:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ALOX15 Gene

ENSEMBL:
Gene Tree for ALOX15 (if available)
TreeFam:
Gene Tree for ALOX15 (if available)

Paralogs for ALOX15 Gene

Paralogs for ALOX15 Gene

(6) SIMAP similar genes for ALOX15 Gene using alignment to 5 proteins:

Pseudogenes.org Pseudogenes for ALOX15 Gene

genes like me logo Genes that share paralogs with ALOX15: view

Variants for ALOX15 Gene

Sequence variations from dbSNP and Humsavar for ALOX15 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs11568142 - 4,639,499(-) CCGGG(C/G)ACGAG reference, missense
rs11568099 - 4,639,458(-) GGCAA(C/G/T)GGCGT reference, missense
rs11568101 - 4,638,613(-) CAACC(A/G)GATTT reference, missense
rs41439950 - 4,639,462(-) GGAGG(G/T)CAACG reference, missense
rs3892408 - 4,638,309(+) CACCA(C/T)GGGGT reference, missense

Variation tolerance for ALOX15 Gene

Residual Variation Intolerance Score: 81.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.61; 65.41% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ALOX15 Gene

HapMap Linkage Disequilibrium report
ALOX15
Human Gene Mutation Database (HGMD)
ALOX15

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for ALOX15 Gene

Disorders for ALOX15 Gene

MalaCards: The human disease database

(4) MalaCards diseases for ALOX15 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
leukomalacia
artery disease
  • arteriopathic disease
periventricular leukomalacia
  • periventricular leucomalacia
coronary artery disease
  • coronary artery anomaly
- elite association - COSMIC cancer census association via MalaCards

UniProtKB/Swiss-Prot

LOX15_HUMAN
  • Note=Disease susceptibility may be associated with variations affecting the gene represented in this entry. Met at position 560 may confer interindividual susceptibility to coronary artery disease (CAD) (PubMed:17959182). {ECO:0000269 PubMed:17959182}.

Relevant External Links for ALOX15

Genetic Association Database (GAD)
ALOX15
Human Genome Epidemiology (HuGE) Navigator
ALOX15
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ALOX15
genes like me logo Genes that share disorders with ALOX15: view

No data available for Genatlas for ALOX15 Gene

Publications for ALOX15 Gene

  1. A near null variant of 12/15-LOX encoded by a novel SNP in ALOX15 and the risk of coronary artery disease. (PMID: 17959182) Assimes T.L. … Quertermous T. (Atherosclerosis 2008) 3 4 23 48 67
  2. An integrated expression phenotype mapping approach defines common variants in LEP, ALOX15 and CAPNS1 associated with induction of IL-6. (PMID: 19942621) Fairfax B.P. … Knight J.C. (Hum. Mol. Genet. 2010) 3 23
  3. Variation in eicosanoid genes, non-fatal myocardial infarction and ischemic stroke. (PMID: 19046748) Lemaitre R.N. … Psaty B.M. (Atherosclerosis 2009) 3 23
  4. Reciprocal regulation of 12- and 15-lipoxygenases by UV-irradiation in human keratinocytes. (PMID: 18755188) Yoo H. … Kim T.Y. (FEBS Lett. 2008) 3 23
  5. A differential association of ALOX15 polymorphisms with bone mineral density in pre- and post-menopausal women. (PMID: 17652958) Cheung C.L. … Kung A.W. (Hum. Hered. 2008) 3 23

Products for ALOX15 Gene

Sources for ALOX15 Gene

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