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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ALOX15 Gene

protein-coding   GIFtS: 66
GCID: GC17M004534

Arachidonate 15-Lipoxygenase

Alzheimer's & Parkinson's Diseases Congress
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Arachidonate 15-Lipoxygenase1 2     15LOX-12
Arachidonate Omega-6 Lipoxygenase2 3     EC 1.13.11.333
15-LOX2 3     LOG153
15-LOX-12     EC 1.13.118
15-lipooxygenase-12     

External Ids:    HGNC: 4331   Entrez Gene: 2462   Ensembl: ENSG000001619057   OMIM: 1523925   UniProtKB: P160503   

Export aliases for ALOX15 gene to outside databases

Previous GC identifers: GC17M004960 GC17M004879 GC17M004485 GC17M004740 GC17M004480


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for ALOX15 Gene: 
ALOX15 (arachidonate 15-lipoxygenase) is a protein-coding gene. Diseases associated with ALOX15 include atherosclerosis, and asthma, and among its related super-pathways are Arachidonic acid metabolism and Metabolic pathways. GO annotations related to this gene include arachidonate 15-lipoxygenase activity and iron ion binding. An important paralog of this gene is ALOX12B.

UniProtKB/Swiss-Prot: LOX15_HUMAN, P16050
Function: Converts arachidonic acid to 15S-hydroperoxyeicosatetraenoic acid. Also acts on C-12 of arachidonate as
well as on linoleic acid

summary for ALOX15 Gene:
Lipoxygenases (LOXs) are a family of non-heme iron dioxygenases that are involved in the production and
metabolism of fatty acid hydroperoxidases. There are six lipoxygenase isozymes; 5-LOX, 12R-LOX, 12S-LOX,
15-LOX-1 and 15-LOX-2, which catalyze the regio-selective addition of oxygen into arachidonic acid, and
epidermal LOX (E-LOX) which metabolizes 12R-hydroperoxyeicosatetraenoic acid (12R-HPETE) to a specific
epoxyalcohol compound. Different isozymes have different physiological roles; 5-, 12R-, 12S- and 15-LOX-1
have proliferative, antiapoptotic and angiogenic functions whilst 15-LOX-2 has roles in differentiation,
growth arrest and the induction of apoptosis. E-LOX, the most divergent member of this family, is involved
in terminal differentiation of keratinocytes and has a major role in skin barrier function. Perturbations in
lipoxygenase enzymes have been implicated in various human diseases including bronchial asthma,
atherosclerosis, osteoporosis and some cancers.

Gene Wiki entry for ALOX15 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000017.10  NT_010718.16  NC_018928.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ALOX15 gene promoter:
         Sp1   LUN-1   LCR-F1   GATA-1   Max   HOXA5   ZID   ATF   c-Myc   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidALOX15 promoter sequence
   Search SABiosciences Chromatin IP Primers for ALOX15

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ALOX15


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17p13.3   Ensembl cytogenetic band:  17p13.2   HGNC cytogenetic band: 17p13.3

ALOX15 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ALOX15 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17M004534:  view genomic region     (about GC identifiers)

Start:
4,534,197 bp from pter      End:
4,545,589 bp from pter
Size:
11,393 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: LOX15_HUMAN, P16050 (See protein sequence)
Recommended Name: Arachidonate 15-lipoxygenase  
Size: 662 amino acids; 74804 Da
Cofactor: Binds 1 iron ion per subunit (By similarity)
Subcellular location: Cytoplasm
1 PDB 3D structure from and Proteopedia for ALOX15:
2ABT (3D)    
Secondary accessions: A8K2P4 Q8N6R7 Q99657

Explore the universe of human proteins at neXtProt for ALOX15: NX_P16050

Explore proteomics data for ALOX15 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P16050

  • 4/20 DME Specific Peptides for ALOX15 (P16050) (see all 20)
     RYTLEIN  CPPDDLA  EEYFSGP  HLGQLDW 

    ALOX15 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    ALOX15 Protein Expression
    REFSEQ proteins: NP_001131.3  
    ENSEMBL proteins: 
     ENSP00000458832   ENSP00000460483   ENSP00000460430   ENSP00000458630   ENSP00000439855  
     ENSP00000293761  
    Reactome Protein details: P16050
    Human Recombinant Protein Products for ALOX15: 
    Browse Purified and Recombinant Proteins at EMD Millipore
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    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for ALOX15
    OriGene Protein Over-expression Lysate for ALOX15
    OriGene MassSpec for ALOX15 
    OriGene Custom Protein Services for ALOX15
    GenScript Custom Purified and Recombinant Proteins Services for ALOX15
    Novus Biologicals ALOX15 Protein
    Novus Biologicals ALOX15 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for ALOX15 

    Gene Ontology (GO): 5/7 cellular component terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005730NOT nucleolus IDA--
    GO:0005737cytoplasm IDA--
    GO:0005811lipid particle IDA19528634
    GO:0005829cytosol TAS--

    ALOX15 for ontologies           About GeneDecksing



    ALOX15 Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
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    OriGene Antibodies for ALOX15
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    Novus Biologicals ALOX15 Antibodies
    Abcam antibodies for ALOX15
    Cloud-Clone Corp. Antibodies for ALOX15 
    ThermoFisher Antibodies for ALOX15
    LSBio Antibodies in human, mouse, rat for ALOX15 

    Assay Products for ALOX15: 
    Browse Kits and Assays available from EMD Millipore
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    GenScript Custom Assay Services for ALOX15
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for ALOX15 
    Cloud-Clone Corp. CLIAs for ALOX15


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    ALOX: Arachidonate lipoxygenases

    IUPHAR Guide to PHARMACOLOGY protein family classification: 15-LOX-1 
    Lipoxygenases

    5/7 InterPro protein domains (see all 7):
     IPR020833 LipOase_Fe_BS
     IPR013819 LipOase_C
     IPR001024 LipOase_LH2
     IPR008976 Lipase_LipOase
     IPR020834 LipOase_CS

    Graphical View of Domain Structure for InterPro Entry P16050

    ProtoNet protein and cluster: P16050

    3 Blocks protein domains:
    IPB000907 Lipoxygenase
    IPB001024 Lipoxygenase
    IPB001885 Mammalian lipoxygenase signature


    UniProtKB/Swiss-Prot: LOX15_HUMAN, P16050
    Similarity: Belongs to the lipoxygenase family
    Similarity: Contains 1 lipoxygenase domain
    Similarity: Contains 1 PLAT domain


    ALOX15 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: LOX15_HUMAN, P16050
    Function: Converts arachidonic acid to 15S-hydroperoxyeicosatetraenoic acid. Also acts on C-12 of arachidonate as
    well as on linoleic acid
    Catalytic activity: Arachidonate + O(2) = (5Z,8Z,11Z,13E)-(15S)-15-hydroperoxyicosa-5,8,11,13-tetraenoate

         Genatlas biochemistry entry for ALOX15:
    arachidonate-15-lipoxygenase,lipid peroxidating enzyme implicated in the pathogenesis of inflammatory disorders as
    well as membrane remodeling,carcinogenesis,and atheroma formation,upregulated by mutant TP53 and maybe involved
    in the development of prostate or colorectal carcinomas

         Enzyme Numbers (IUBMB): EC 1.13.11.331 EC 1.13.112

         Gene Ontology (GO): 5/8 molecular function terms (GO ID links to tree view) (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004052arachidonate 12-lipoxygenase activity IDA1944593
    GO:0005506iron ion binding ISS--
    GO:0005515protein binding IPI--
    GO:0016165linoleate 13S-lipoxygenase activity ----
    GO:0016702oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen ----
         
    ALOX15 for ontologies           About GeneDecksing


    Phenotypes:
         4 GenomeRNAi human phenotypes for ALOX15:
     Decreased focal adhesion (FA)   Decreased homologous recombina  Increased G1 DNA content  Increased number of mitotic ce 

         8 MGI mutant phenotypes (inferred from 1 allele(MGI details for Alox15):
     cardiovascular system  endocrine/exocrine gland  hematopoietic system  immune system  integument 
     mortality/aging  reproductive system  tumorigenesis 

    ALOX15 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Alox15tm1Fun for ALOX15

       inGenious Targeting Laboratory - Custom generated mouse model solutions for ALOX15 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for ALOX15

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for ALOX15 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for ALOX15 

    miRNA
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    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate ALOX15
    SwitchGear 3'UTR luciferase reporter plasmidALOX15 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for ALOX15
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ALOX15

    Gene Editing
    Products:
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    Sirion Biotech Customized adenovirus for overexpression of ALOX15

    Clone
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    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for ALOX15 (see all 8)
    OriGene ORF clones in mouse, rat for ALOX15
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: ALOX15 (NM_001140)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ALOX15
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ALOX15
    Sirion Biotech Customized lentivirus for stable overexpression of ALOX15 
                         Customized lentivirus expression plasmids for stable overexpression of ALOX15 

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ALOX15


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for ALOX15 About   (see all 9)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Arachidonic acid metabolism
    Arachidonic acid metabolism0.44
    Synthesis of Leukotrienes (LT) and Eoxins (EX)0.41
    Arachidonic acid metabolism0.44
    HETE and HPETE biosynthesis and metabolism0.35
    2Metabolism
    Metabolism0.40
    Metabolism of lipids and lipoproteins0.34
    Metabolic pathways0.40
    3lipoxin biosynthesis
    lipoxin biosynthesis0.67
    resolvin D biosynthesis0.67
    4Synthesis of 15-eicosatetraenoic acid derivatives
    Synthesis of 15-eicosatetraenoic acid derivatives0.50
    Synthesis of 12-eicosatetraenoic acid derivatives0.50
    5Apoptotic Pathways in Synovial Fibroblasts
    DHA Signaling0.74

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 EMD Millipore Pathway for ALOX15
        HETE and HPETE biosynthesis and metabolism

    1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for ALOX15
        DHA Signaling

    1 GeneGo (Thomson Reuters) Pathway for ALOX15
        HETE and HPETE biosynthesis and metabolism

    4 BioSystems Pathways for ALOX15
        Eicosanoid Synthesis
    lipoxin biosynthesis
    IL4-mediated signaling events
    resolvin D biosynthesis

    5/6        Reactome Pathways for ALOX15 (see all 6)
        Metabolism
    Synthesis of Leukotrienes (LT) and Eoxins (EX)
    Arachidonic acid metabolism
    Synthesis of 12-eicosatetraenoic acid derivatives
    Synthesis of 15-eicosatetraenoic acid derivatives


    4         Kegg Pathways  (Kegg details for ALOX15):
        Arachidonic acid metabolism
    Linoleic acid metabolism
    Metabolic pathways
    Serotonergic synapse

    UniProtKB/Swiss-Prot: LOX15_HUMAN, P16050
    Pathway: Lipid metabolism; leukotriene D4 biosynthesis


    ALOX15 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for ALOX15

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/48 Interacting proteins for ALOX15 (ENSP000002937614) via UniProtKB, MINT, STRING, and/or I2D (see all 48)

    InteractantInteraction Details
    GeneCardExternal ID(s)
    ALOX12ENSP000002515354STRING: ENSP00000251535
    ALOX12BENSP000003151674STRING: ENSP00000315167
    ALOX15BENSP000003695304STRING: ENSP00000369530
    ALOX5ENSP000003635124STRING: ENSP00000363512
    CYP2B6ENSP000003246484STRING: ENSP00000324648
    About this table

    Gene Ontology (GO): 5/23 biological process terms (GO ID links to tree view) (see all 23):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001503ossification ISS--
    GO:0002820negative regulation of adaptive immune response ISS--
    GO:0006629lipid metabolic process ----
    GO:0006646phosphatidylethanolamine biosynthetic process ISS--
    GO:0006691leukotriene metabolic process TAS--

    ALOX15 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    ALOX15 for compounds           About GeneDecksing

    EMD Millipore small molecules for ALOX15:
    Small Molecule - inhibitor
    Browse drugs & compounds from Enzo Life Sciences

    Compounds for ALOX15 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    BAY-X 1005Orally active 5-lipoxygenase activating protein (FLAP) inhibitor[128253-31-6]
    BW-B 70C5-Lipoxygenase inhibitor[134470-38-5]
    ZileutonOrally active 5-LOX inhibitor[111406-87-2]
    MK 886Inhibitor of 5-lipoxygenase-activating protein (FLAP)[118414-82-7]
    Baicalein5- and 12-Lipoxygenase inhibitor[491-67-8]

    7 HMDB Compounds for ALOX15    About this table
    CompoundSynonyms CAS #PubMed Ids
    13-L-Hydroperoxylinoleic acid(13S,9z,11e)-13-hydroperoxy-9,11-octadecadienoic acid (see all 18)33964-75-9--
    15(S)-HPETE(5Z,8Z,11Z,13E)-(15S)-15-Hydroperoxyicosa-5,8,11,13-tetraenoate (see all 8)70981-96-3--
    9(S)-HPODE ----
    Arachidonic acid5,8,11,14-Eicosatetraenoic acid (see all 16)506-32-1--
    IronArmco iron (see all 19)7439-89-6--
    Linoleic acid(9Z,12Z)-9,12-Octadecadienoate (see all 26)60-33-3--
    OxygenOxygen (see all 5)7782-44-7--

    1 DrugBank Compound for ALOX15    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    (2E)-3-(2-OCT-1-YN-1-YLPHENYL)ACRYLIC ACID-- --target--10592235

    10/19 Novoseek inferred chemical compound relationships for ALOX15 gene (see all 19)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    (13s)-hydroxyoctadecadienoic acid 90.9 5 10506115 (1), 20388757 (1), 12510822 (1)
    15hpete 82.5 2 17305569 (1), 10332966 (1)
    15-hydroxyeicosatetraenoic acid 81.6 7 10332966 (3), 17519227 (1), 20008149 (1)
    arachidonic acid 79.9 50 1662607 (2), 8195716 (2), 16598376 (2), 10332966 (2) (see all 29)
    13-hpode 73.9 7 10400618 (4)
    linoleic acid 59.6 5 10506115 (1), 9931410 (1), 12510822 (1), 17869078 (1)
    n-(4-hydroxyphenyl)retinamide 49.2 3 12858336 (1), 12234979 (1)
    gamma-linolenic acid 44.9 3 15850718 (1), 12510822 (1)
    pge2 27 2 12510822 (1)
    lipid 22.1 5 10400618 (2), 1729692 (1), 17918787 (1), 19804839 (1)

    Search CenterWatch for drugs/clinical trials and news about ALOX15 / LOX15

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for ALOX15 gene: 
    NM_001140.3  

    Unigene Cluster for ALOX15:

    Arachidonate 15-lipoxygenase
    Hs.73809  [show with all ESTs]
    Unigene Representative Sequence: NM_001140
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000570836(uc002fyh.3 uc010vsd.2 uc010vse.2) ENST00000574640
    ENST00000576572 ENST00000572265 ENST00000573740 ENST00000576394 ENST00000545513
    ENST00000293761

    miRNA
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      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ALOX15

    Additional mRNA sequence: 

    AK290309.1 AK296792.1 AK296821.1 AK296904.1 AK312557.1 AK316126.1 BC029032.1 M23892.1 

    4 DOTS entries:

    DT.100020039  DT.120922324  DT.95153784  DT.121002907 

    23 AceView cDNA sequences:

    BM975623 BQ957032 BX113915 BX282722 BM981991 CB305636 NM_001140 M23892 
    BM975468 BM976589 BC029032 AU119118 CA436179 CA311119 BX644955 BI823909 
    BQ276406 BV196138 CA405412 BE538114 AI864921 BU935146 CN478760 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for ALOX15    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10
    SP1:                                                                              
    SP2:                                                                              
    SP3:                                                                              
    SP4:                                                                              
    SP5:                                                                              


    ECgene alternative splicing isoforms for ALOX15

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ALOX15 expression in normal human tissues (normalized intensities)      ALOX15 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGTATCTTCA
    ALOX15 Expression
    About this image


    ALOX15 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/7 selected tissues (see all 7) fully expand
     
     Nose (Sensory Organs)    fully expand to see all 3 entries
             sensory organ/nose/nasal cavity   
     
     Epithelium (Respiratory System)    fully expand to see all 2 entries
             bronchial epithelia   
     
     Gut Tube (Gastrointestinal Tract)
             Foregut
     
     Oral Cavity (Gastrointestinal Tract)
             mouth   
     
     Blood (Hematopoietic System)
             Peripheral Blood Immature Myeloid Dendritic Cells   

    See ALOX15 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ALOX15

    SOURCE GeneReport for Unigene cluster: Hs.73809
        SABiosciences Expression via Pathway-Focused PCR Array including ALOX15: 
              Drug Metabolism in human mouse rat

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for ALOX15 gene from 2/8 species (see all 8)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Alox151 , 5 arachidonate 15-lipoxygenase1, 5 77.79(n)1
    73.72(a)1
      11 (42.99 cM)5
    116871  NM_009660.31  NP_033790.31 
     703441525 
    zebrafish
    (Danio rerio)
    Actinopterygii alox126
    arachidonate 12-lipoxygenase
    44(a)
    1 → many
    7(27155574-27173814)


    ENSEMBL Gene Tree for ALOX15 (if available)
    TreeFam Gene Tree for ALOX15 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ALOX15 gene
    ALOX12B2  ALOX52  ALOX15B2  ALOXE32  ALOX122  
    6 SIMAP similar genes for ALOX15 using alignment to 5 protein entries:     LOX15_HUMAN (see all proteins):
    arachidonate 12-lipoxygenase    ALOX12    ALOX5    ALOX15B    ALOX12B    ALOXE3

    ALOX15 for paralogs           About GeneDecksing


    2 Pseudogenes.org Pseudogenes for ALOX15
    PGOHUM00000237211 PGOHUM00000236709


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/507 SNPs in ALOX15 are shown (see all 507)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs18093641,2
    C,F,H--4533844(+) ATTTTT/AAAAAA 1 -- int117Minor allele frequency- A:0.08NS NA WA CSA EA 1095
    rs1887427901,2
    --4533859(+) TAGGCC/TGGGCA 1 -- int10--------
    rs1928092341,2
    --4533880(+) CACCTA/GTAATC 1 -- int10--------
    rs115681361,2
    C,F--4533887(-) GTGCTG/AGGATT 1 -- int12Minor allele frequency- A:0.02NS 82
    rs1837874031,2
    C--4534001(+) GGGCGC/TGGTGG 1 -- int10--------
    rs115681501,2
    C,F--4534011(-) CAGGCG/ACCTGC 1 -- int12Minor allele frequency- A:0.01NS 84
    rs115681351,2
    C,F--4534113(-) TGCCCA/TGGCTG 1 -- int12Minor allele frequency- T:0.04NS 84
    rs1918438261,2
    --4534334(+) CCTAGA/GCAACA 1 -- ut310--------
    rs115681341,2
    C,F--4534357(-) TTCGTG/AGAGAC 1 -- ut318Minor allele frequency- A:0.06NS NA WA CSA 268
    rs1840611201,2
    --4534395(+) GGCATA/GAGCCT 1 -- ut310--------

    HapMap Linkage Disequilibrium report for ALOX15 (4534197 - 4545589 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for ALOX15: --

    Human Gene Mutation Database (HGMD): ALOX15
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing ALOX15
    DNA2.0 Custom Variant and Variant Library Synthesis for ALOX15

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 152392    OMIM disorders: --

    20/28 diseases for ALOX15 (see all 28):    About MalaCards
    atherosclerosis    asthma    synovitis    prostate adenocarcinoma
    colorectal cancer    peritonitis    medulloblastoma    endometriosis
    arthritis    osteoarthritis    malaria    meningioma
    infertility    rheumatoid arthritis    malignant glioma    myocardial infarction
    prostatitis    colon cancer    neuroblastoma    prostate cancer


    ALOX15 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    10/11 Novoseek inferred disease relationships for ALOX15 gene (see all 11)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    atherosclerosis 45.9 10 17869078 (2), 18000963 (1), 17439326 (1), 18392641 (1) (see all 7)
    inflammation 36.1 7 14740455 (1), 17439326 (1), 19942621 (1), 17164146 (1) (see all 5)
    colorectal cancer 20.8 1 14566836 (1)
    asthma 20.8 4 17439326 (1), 19804839 (1), 16320347 (1), 8358018 (1)
    rheumatoid arthritis 12.9 1 10332966 (1)
    arthritis 12.7 2 17439326 (1), 16320347 (1)
    prostate cancer 9.84 1 15850718 (1)
    osteoporosis 2.61 1 16799083 (1)
    metastasis 0 1 17721268 (1)
    tumors 0 2 14740455 (1)

    Genetic Association Database (GAD): ALOX15
    Human Genome Epidemiology (HuGE) Navigator: ALOX15 (32 documents)

    Export disorders for ALOX15 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ALOX15 gene, integrated from 9 sources (see all 227):
    (articles sorted by number of sources associating them with ALOX15)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Human ALOX12, but not ALOX15, is associated with BMD in white men and women. (PubMed id 16598376)1, 4, 9 Ichikawa S....Econs M.J. (2006)
    2. Polymorphisms in ALOX12, but not ALOX15, are significantly associated with BMD in postmenopausal women. (PubMed id 17520163)1, 4, 9 Mullin B.H....Wilson S.G. (2007)
    3. The c.-292C>T promoter polymorphism increases reticulocyte-type 15-lipoxygenase-1 activity and could be atheroprotective. (PubMed id 17439326)1, 4, 9 Wittwer J....Hersberger M. (2007)
    4. A near null variant of 12/15-LOX encoded by a novel SNP in ALOX15 and the risk of coronary artery disease. (PubMed id 17959182)1, 4, 9 Assimes T.L....Quertermous T. (2008)
    5. 15-Lipoxygenase gene variants are associated with carotid plaque but not carotid intima-media thickness. (PubMed id 18392641)1, 4, 9 McCaskie P.A....Palmer L.J. (2008)
    6. Purification of two forms of arachidonate 15-lipoxygenase from human leukocytes. (PubMed id 1662607)1, 2, 9 Izumi T.... Samuelsson B. (1991)
    7. Variation in eicosanoid genes, non-fatal myocardial infarction and ischemic stroke. (PubMed id 19046748)1, 4, 9 Lemaitre R.N....Psaty B.M. (2008)
    8. Association of a single nucleotide polymorphism in the lipoxygenase ALOX15 5'-flanking region (-5229G/A) with bone mineral density. (PubMed id 15838625)1, 4, 9 Urano T....Inoue S. (2005)
    9. Risk of meningioma and common variation in genes rela ted to innate immunity. (PubMed id 20406964)1, 4 Rajaraman P....Inskip P.D. (2010)
    10. Common polymorphisms in ITGA2, PON1 and THBS2 are ass ociated with coronary atherosclerosis in a candidate gene association study of the Chinese Han population. (PubMed id 20485444)1, 4 Wang Y....Huang W. (2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 246 HGNC: 433 AceView: ALOX15 Ensembl:ENSG00000161905 euGenes: HUgn246
    ECgene: ALOX15 Kegg: 246 H-InvDB: ALOX15

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ALOX15 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for ALOX15 Genetics and Cytogenetics in Oncology and Haematology
    SeattleSNPshttp://pga.gs.washington.edu/data/alox15/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for ALOX15 gene:
    Search GeneIP for patents involving ALOX15

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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