ALOX15 Gene
protein-coding GIFtS: 65
GCID: GC17M004534
|
|
arachidonate 15-lipoxygenase
| |
Aliases
for ALOX15 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Arachidonate 15-Lipoxygenase1 2 | | 15LOX-12 | | 15-LOX-11 2 | | EC 1.13.11.333 | | Arachidonate Omega-6 Lipoxygenase2 3 | | LOG153 | | 15-LOX2 3 | | EC 1.13.118 | | 15-Lipooxygenase-11 | | |
Export aliases for ALOX15 gene to outside databasesPrevious GC identifers: GC17M004960 GC17M004879 GC17M004485 GC17M004740 GC17M004480 |
Summaries
for ALOX15 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: LOX15_HUMAN, P16050Function: Converts arachidonic acid to 15S-hydroperoxyeicosatetraenoic acid. Also acts on C-12 of arachidonate as wellas on linoleic acid
 summary
for ALOX15: Lipoxygenases (LOXs) are a family of non-heme iron dioxygenases that are involved in the production and
metabolism of fatty acid hydroperoxidases. There are six lipoxygenase isozymes; 5-LOX, 12R-LOX, 12S-LOX,
15-LOX-1 and 15-LOX-2, which catalyze the regio-selective addition of oxygen into arachidonic acid, and
epidermal LOX (E-LOX) which metabolizes 12R-hydroperoxyeicosatetraenoic acid (12R-HPETE) to a specific
epoxyalcohol compound. Different isozymes have different physiological roles; 5-, 12R-, 12S- and 15-LOX-1
have proliferative, antiapoptotic and angiogenic functions whilst 15-LOX-2 has roles in differentiation,
growth arrest and the induction of apoptosis. E-LOX, the most divergent member of this family, is involved
in terminal differentiation of keratinocytes and has a major role in skin barrier function. Perturbations in
lipoxygenase enzymes have been implicated in various human diseases including bronchial asthma,
atherosclerosis, osteoporosis and some cancers.
Gene Wiki entry for ALOX15
|
Genomic Views
for ALOX15 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000017.10 NC_018928.1 NT_010718.16
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the ALOX15 gene promoter:
Sp1 LUN-1 LCR-F1 GATA-1 Max HOXA5 ZID ATF c-Myc
Other transcription factors
Search SABiosciences Chromatin IP Primers for ALOX15
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ALOX15 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 17p13.3 Ensembl cytogenetic band: 17p13.2 HGNC cytogenetic band: 17p13.3ALOX15 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 17 GeneLoc Exon Structure GeneLoc location for GC17M004534: view genomic region
(about GC identifiers)
Start:
|
4,534,197 bp from pter |
End:
|
4,545,589 bp from pter |
Size:
|
11,393 bases |
Orientation:
|
minus strand |
|
Proteins
for ALOX15 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: LOX15_HUMAN, P16050 (See
protein sequence)Recommended Name: Arachidonate 15-lipoxygenase Size: 662 amino acids; 74804 Da
Cofactor: Binds 1 iron ion per subunit (By similarity)
Subcellular location: Cytoplasm
1 PDB 3D structure from  and Proteopedia  for ALOX15:2ABT (3D)
Secondary accessions: A8K2P4 Q8N6R7 Q99657Explore the universe of human proteins at neXtProt for ALOX15: NX_P16050
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_P16050
4/20 DME Specific Peptides for ALOX15 (P16050) (see all 20)
ALOX15 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_001131.3
ENSEMBL proteins: ENSP00000458832 ENSP00000460483 ENSP00000460575 ENSP00000460430 ENSP00000458630 ENSP00000439855 ENSP00000293761 Reactome Protein details: P16050
Human Recombinant Protein Products for ALOX15:
Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view): About this table
ALOX15 for ontologies About GeneDecksing
ALOX15 Antibody Products:
Assay Products for ALOX15: |
Protein
Domains /
Families
for ALOX15 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
ALOX15 for domains About GeneDecksing
5/7 InterPro domains/families (see all 7):Graphical View of Domain Structure for InterPro Entry P16050ProtoNet protein and cluster: P16050 3 Blocks protein families: IPB000907 Lipoxygenase IPB001024 Lipoxygenase IPB001885 Mammalian lipoxygenase signature
UniProtKB/Swiss-Prot: LOX15_HUMAN, P16050Similarity: Belongs to the lipoxygenase familySimilarity: Contains 1 lipoxygenase domainSimilarity: Contains 1 PLAT domain |
Function
for ALOX15 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Molecular Function:
UniProtKB/Swiss-Prot Summary: LOX15_HUMAN, P16050Function: Converts arachidonic acid to 15S-hydroperoxyeicosatetraenoic acid. Also acts on C-12 of arachidonate as wellas on linoleic acidCatalytic activity: Arachidonate + O(2) = (5Z,8Z,11Z,13E)-(15S)-15-hydroperoxyicosa-5,8,11,13-tetraenoate Genatlas biochemistry entry for ALOX15:arachidonate-15-lipoxygenase,lipid peroxidating enzyme implicated in the pathogenesis of inflammatory disorders as wellas membrane remodeling,carcinogenesis,and atheroma formation,upregulated by mutant TP53 and maybe involved in thedevelopment of prostate or colorectal carcinomas
Enzyme Numbers (IUBMB): EC 1.13.11.331 EC 1.13.112
Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0004052 | arachidonate 12-lipoxygenase activity |
-- | -- | | GO:0005506 | iron ion binding |
IEA | -- | | GO:0016165 | lipoxygenase activity |
IEA | -- | | GO:0047977 | hepoxilin-epoxide hydrolase activity |
-- | -- | | GO:0050473 | arachidonate 15-lipoxygenase activity |
IEA | -- |
ALOX15 for ontologies About GeneDecksing
Phenotypes:
4 GenomeRNAi human phenotypes for ALOX15:
8 MGI mutant phenotypes (inferred from 1 allele ) (MGI details for Alox15):
ALOX15 for phenotypes About GeneDecksing
Animal Models:
Mouse knock-out Alox15tm1Fun for ALOX15
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ALOX15 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ALOX15 (see all 2)
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: ALOX15 (NM_001140) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ALOX15 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ALOX15 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ALOX15 |
|
Pathways & Interactions
for ALOX15 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways - 5/7 super-pathways (see all 7) About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Arachidonic acid metabolism | | | 2 | Metabolism | | | 3 | Synthesis of 15-eicosatetraenoic acid derivatives | | | 4 | IL4-mediated signaling events | | | 5 | Apoptotic Pathways in Synovial Fibroblasts | |
Pathway sources
See GeneCards unified pathways
Show all pathways
1 EMD Millipore Pathway for ALOX15
1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for ALOX15
1  GeneGo (Thomson Reuters) Pathway for ALOX15
2  BioSystems Pathways for ALOX15
5/6 
Reactome Pathways for ALOX15 (see all 6)
3 
Kegg Pathways (Kegg details for ALOX15):
UniProtKB/Swiss-Prot: LOX15_HUMAN, P16050Pathway: Lipid metabolism; leukotriene D4 biosynthesis
ALOX15 for pathways About GeneDecksing
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for ALOX15
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/48 Interacting proteins for ALOX15 (ENSP000002937614) via UniProtKB, MINT, STRING, and/or I2D (see all 48)
About this table
Gene Ontology (GO): 5/7 biological process terms (GO ID links to tree view) (see all 7): About this table
ALOX15 for ontologies About GeneDecksing
|
Drugs & Compounds
for ALOX15 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
ALOX15 for compounds About GeneDecksing
Compounds for ALOX15 available from Tocris Bioscience About this table
| Compound | Action |
CAS
# |
|---|
| 2-TEDC | 5-, 12-, 15-Lipoxygenase inhibitor | [132465-10-2] | | PD 146176 | Selective 15-lipoxygenase inhibitor | [4079-26-9] |
7 HMDB Compounds for ALOX15 About this table
| Compound | Synonyms |
CAS
# | PubMed Ids |
|---|
| 13-L-Hydroperoxylinoleic acid | (13S,9z,11e)-13-hydroperoxy-9,11-octadecadienoic acid (see all 18) | 33964-75-9 | -- | | 15(S)-HPETE | (5Z,8Z,11Z,13E)-(15S)-15-Hydroperoxyicosa-5,8,11,13-tetraenoate (see all 8) | 70981-96-3 | -- | | 9(S)-HPODE | | -- | -- | | Arachidonic acid | 5,8,11,14-Eicosatetraenoic acid (see all 16) | 506-32-1 | -- | | Iron | Armco iron (see all 19) | 7439-89-6 | -- | | Linoleic acid | (9Z,12Z)-9,12-Octadecadienoate (see all 26) | 60-33-3 | -- | | Oxygen | Oxygen (see all 5) | 7782-44-7 | -- |
1 DrugBank Compound for ALOX15 About this table
10/19 Novoseek chemical compound relationships for ALOX15 gene (see all 19) About this table
| Compound |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| (13s)-hydroxyoctadecadienoic acid |
90.9 |
5 |
10506115 (1), 20388757 (1), 12510822 (1) |
| 15hpete |
82.5 |
2 |
17305569 (1), 10332966 (1) |
| 15-hydroxyeicosatetraenoic acid |
81.6 |
7 |
10332966 (3), 17519227 (1), 20008149 (1) |
| arachidonic acid |
79.9 |
50 |
1662607 (2), 8195716 (2), 16598376 (2), 10332966 (2) (see all 29) |
| 13-hpode |
73.9 |
7 |
10400618 (4) |
| linoleic acid |
59.6 |
5 |
10506115 (1), 9931410 (1), 12510822 (1), 17869078 (1) |
| n-(4-hydroxyphenyl)retinamide |
49.2 |
3 |
12858336 (1), 12234979 (1) |
| gamma-linolenic acid |
44.9 |
3 |
15850718 (1), 12510822 (1) |
| pge2 |
27 |
2 |
12510822 (1) |
| lipid |
22.1 |
5 |
10400618 (2), 1729692 (1), 17918787 (1), 19804839 (1) |
Search CenterWatch for drugs/clinical trials and news about ALOX15 / LOX15
|
Transcripts
for ALOX15 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for ALOX15 gene: NM_001140.3 Unigene Cluster for ALOX15: Arachidonate 15-lipoxygenase Hs.73809 [show with all ESTs]Unigene Representative Sequence: NM_0011409 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000570836(uc002fyh.3 uc010vsd.2 uc010vse.2) ENST00000574640
ENST00000576572 ENST00000573585 ENST00000572265 ENST00000573740 ENST00000576394
ENST00000545513 ENST00000293761
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ALOX15 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ALOX15 (see all 2)
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: ALOX15 (NM_001140) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ALOX15 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ALOX15 |
Additional cDNA sequence: AK290309.1 AK296792.1 AK296821.1 AK296904.1 AK312557.1 AK316126.1 BC029032.1 M23892.1 4 DOTS entries: DT.100020039 DT.120922324 DT.95153784 DT.121002907 23 AceView cDNA sequences: BX282722 BQ957032 BM975623 BM975468 BM981991 BC029032 BX113915 BM976589 CB305636 NM_001140 M23892 AU119118 BX644955 CA436179 BI823909 BQ276406 CA311119 CA405412 BV196138 BE538114 AI864921 BU935146 CN478760
GeneLoc Exon Structure
5 Alternative Splicing Database (ASD) splice patterns (SP) for ALOX15 About this scheme
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3 | ^ | 4a | · | 4b | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8a | · | 8b | ^ | 9 | ^ | 10 |
|---|
|
| SP1: | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for ALOX15
|
Expression
for ALOX15 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| ALOX15 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TGTATCTTCA
About this image
See ALOX15 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for ALOX15
SOURCE GeneReport for Unigene cluster: Hs.73809
SABiosciences Expression via Pathway-Focused PCR Array including ALOX15:
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ALOX15
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat ALOX15 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ALOX15 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ALOX15 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ALOX15 |
Orthologs
for ALOX15 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for ALOX15 gene from 4/17 species (see all 17) About this table
ENSEMBL Gene Tree for ALOX15 (if available)
TreeFam Gene Tree for ALOX15 (if available) |
Paralogs
for ALOX15 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for ALOX15 gene
- ALOX52 ALOX12B2 ALOX15B2 ALOX122 ALOXE32
6 SIMAP similar genes for ALOX15 using alignment to 6 protein entries: LOX15_HUMAN (see all proteins):arachidonate 12-lipoxygenase ALOX12 ALOX5 ALOX15B ALOX12B ALOXE3
ALOX15 for paralogs About GeneDecksing
2 Pseudogenes.org Pseudogenes for ALOX15
PGOHUM00000237211 PGOHUM00000236709
|
Genomic Variants
for ALOX15 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 17 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for ALOX15 (4534197 - 4545589 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for ALOX15: --
Human Gene Mutation Database (HGMD): ALOX15
| SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ALOX15 |
|
Disorders
/ Diseases
for ALOX15 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
ALOX15 for disorders About GeneDecksing
OMIM gene information: 152392
OMIM disorders: --
20/33  diseases for ALOX15 (see all 33): About MalaCardsbronchial asthma osteoporosis asthma atherosclerosis
rheumatoid arthritis myocardial infarction hodgkin's lymphoma synovitis
arthritis neurodegenerative disease colorectal cancer lung cancer
prostate cancer pulmonary disease prostate adenocarcinoma medulloblastoma
alzheimer's disease endometriosis prostatitis colon cancer
10/11 Novoseek disease relationships for ALOX15 gene (see all 11) About this table
| Disease |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| atherosclerosis |
45.9 |
10 |
17869078 (2), 18000963 (1), 17439326 (1), 18392641 (1) (see all 7) |
| inflammation |
36.1 |
7 |
14740455 (1), 17439326 (1), 19942621 (1), 17164146 (1) (see all 5) |
| colorectal cancer |
20.8 |
1 |
14566836 (1) |
| asthma |
20.8 |
4 |
17439326 (1), 19804839 (1), 16320347 (1), 8358018 (1) |
| rheumatoid arthritis |
12.9 |
1 |
10332966 (1) |
| arthritis |
12.7 |
2 |
17439326 (1), 16320347 (1) |
| prostate cancer |
9.84 |
1 |
15850718 (1) |
| osteoporosis |
2.61 |
1 |
16799083 (1) |
| metastasis |
0 |
1 |
17721268 (1) |
| tumors |
0 |
2 |
14740455 (1) |
Genetic Association Database (GAD): ALOX15
Human Genome Epidemiology (HuGE) Navigator: ALOX15 (32 documents)
Export disorders for ALOX15 gene to outside databases
|
Publications
for ALOX15 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for ALOX15 gene, integrated from 9 sources (see all 216):
(articles sorted by number of sources associating them with ALOX15) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Purification of two forms of arachidonate 15-lipoxygenase from human leukocytes. (PubMed id 1662607)1, 2, 9 Izumi T.... Samuelsson B. (1991)
- Association of a single nucleotide polymorphism in the lipoxygenase ALOX15 5'-flanking region (-5229G/A) with bone mineral density. (PubMed id 15838625)1, 4, 9 Urano T....Inoue S. (2005)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Human 15-lipoxygenase gene promoter: analysis and identification of DNA binding sites for IL-13-induced regulatory factors in monocytes. (PubMed id 9700053)1, 2 Kelavkar U.... Badr K. (1998)
- Characterization and sequence of an additional 15-lipoxygenase transcript and of the human gene. (PubMed id 9224951)1, 2 Kritzik M.R....Sigal E. (1997)
- Characterization of human 12-lipoxygenase genes. (PubMed id 1570320)1, 3 Funk C.D.... Samuelsson B. (1992)
- A primary determinant for lipoxygenase positional specificity. (PubMed id 1944593)1, 2 Sloane D.L.... Sigal E. (1991)
- Molecular cloning and primary structure of human 15-lipoxygenase. (PubMed id 3202857)1, 2 Sigal E.... Nadel J.A. (1988)
- Arachidonate 15-lipoxygenase (omega-6 lipoxygenase) from human leukocytes. Purification and structural homology to other mammalian lipoxygenases. (PubMed id 3356688)1, 2 Sigal E.... Nadel J.A. (1988)
- Human ALOX12, but not ALOX15, is associated with BMD in white men and women. (PubMed id 16598376)1, 9 Ichikawa S....Econs M.J. (2006)
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External Searches for ALOX15 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
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Genome Databases showing ALOX15 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
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Other Databases showing ALOX15 gene
(According to HUGE)
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Specialized Databases showing ALOX15 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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About This Section
| Patent Information for ALOX15 gene:
Search GeneIP for patents involving ALOX15
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Products
for ALOX15 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
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| | |  | OriGene Antibodies for ALOX15 | | OriGene shRNA RFP for ALOX15 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ALOX15 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ALOX15 | | | OriGene Protein Over-expression Lysate for ALOX15 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for ALOX15 | | OriGene 3'-UTR Clone for ALOX15 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ALOX15 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ALOX15 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for ALOX15 | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for ALOX15 | | OriGene Custom Protein Services for ALOX15 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat ALOX15 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ALOX15 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ALOX15 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ALOX15 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ALOX15 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ALOX15 |
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| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ALOX15 |
|  |  |  |  | | | | ThermoFisher Antibodies for ALOX15 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ALOX15 |
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